Monthly Archives: June 2012

Industrial Biotechnology Companies Receive Green Chemistry Awards for Cleaner, Safer Production and Energy Savings

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WASHINGTON--(BUSINESS WIRE)--

Industrial biotechnology is being used to improve production of cleaner, healthier products, saving energy, reducing costs, and reducing pollution from manufacturing. The Biotechnology Industry Organization (BIO) today congratulated member companies Elevance Renewable Sciences and Codexis on receiving 2012 Presidential Green Chemistry Challenge Awards.

Industrial biotechnology is already being used to produce products for the home that are cleaner and safer for the environment, require less energy for manufacturing and lower production costs, said Brent Erickson, executive vice president of BIOs Industrial & Environmental Section. BIO congratulates our members who have been recognized through the Presidential Green Chemistry Awards for their pioneering advances in applying industrial biotechnology to manufacturing. Their achievements show that more widespread adoption of industrial biotechnology processes can help establish a new path for sustainable economic growth and job creation, without continued reliance on foreign oil.

Elevance Renewable Sciences, Inc. received a Small Business Award for producing high-performing, renewable specialty chemicals at advantageous costs. Elevance employs Nobel-prize-winning catalyst technology to produce novel, high-performance renewable specialty chemicals for many uses that combine the benefits of both petrochemicals and biobased chemicals. The technology consumes significantly less energy and reduces greenhouse gas emissions by 50 percent compared to petrochemical technologies.

Codexis, Inc. received a Greener Synthetic Pathways Award for an efficient biocatalytic process to manufacture simvastatin, a leading drug for treating high cholesterol. The previous multistep method for producing simvastatin was wasteful and used large amounts of hazardous reagents. Codexis optimized the chemical process to greatly reduce hazard and waste, be more cost-effective and meet the needs of customers.

About BIO

BIO represents more than 1,100 biotechnology companies, academic institutions, state biotechnology centers and related organizations across the United States and in more than 30 other nations. BIO members are involved in the research and development of innovative healthcare, agricultural, industrial and environmental biotechnology products. BIO also produces the BIO International Convention, the worlds largest gathering of the biotechnology industry, along with industry-leading investor and partnering meetings held around the world. BIO produces BIOtech NOW, an online portal and monthly newsletter chronicling innovations transforming our world. Subscribe to BIOtech NOW.

Upcoming BIO Events

2012 BIO International Convention June 18-21, 2012 Boston, MA

BIO Business Forum June 18 21, 2012 Boston, MA

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American Oriental Bioengineering Announces Appointment of Audit Committee Chairman

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NEWARK, N.J., June 18, 2012 /PRNewswire-Asia-FirstCall/ -- The Board of Directors (the "Board") of American Oriental Bioengineering, Inc. , (the "Company", or "we" ), by unanimous written consent appointed Cosimo J. Patti, an independent director of the Board since 2004, as the Chairman of the audit committee of the Board.

Mr. Patti has no family relationships with any of the executive officers or directors of the Company. There have been no transactions in the past two years to which the Company or any of its subsidiaries was, or is to be a party, in which Mr. Patti had or will have a direct or indirect material interest.

About American Oriental Bioengineering, Inc.

American Oriental Bioengineering, Inc. is a pharmaceutical company dedicated to improving health through the development, manufacture and commercialization of a broad range of prescription and over the counter products.

Safe Harbor Statement

Statements made in this press release are forward-looking and are made pursuant to the safe harbor provisions of the Securities Litigation Reform Act of 1995. Such statements involve risks and uncertainties that may cause actual results to differ materially from those set forth in these statements. The economic, competitive, governmental, technological and other factors identified in the Company's filings with the Securities and Exchange Commission may cause actual results or events to differ materially from those described in the forward looking statements in this press release. The Company undertakes no obligation to publicly update or revise any forward-looking statements, whether because of new information, future events, or otherwise.

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American Oriental Bioengineering Announces Appointment of Audit Committee Chairman

Depth of the Field

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Linda McCormick, a pollution-prevention expert with a biochemistry degree from UC Berkeley, said recycling was not a priority at the University when she first became a resource conservation manager for the UNM Recycling Program in 2003.

McCormick said she is proud to watch the program grow, and that UNM recycled 125,000 tons of material last year. McCormick said the recycling program includes eight staff members who pick up recyclable materials from all over campus every day. She said staff members separate the recyclable materials into different categories to put into bales, which are then sold to a range of recycling companies. She said the program helps the University save a lot of money on trash disposal.

McCormick said the program utilizes a lot of unused items from other departments. She said the program reuses trash bins from Athletics, which adds a great component to the recycling program.

The UNM Recycling Program welcomes students, staff and faculty members to drop off recyclable trash at their location next to Tucker Avenue and Camino del Servicio on North Campus.

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Depth of the Field

Scientists discover how key enzyme involved in aging, cancer assembles

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A model representing the interaction of the p65 protein with telomerase RNA. The RNA backbone of telomerase (multicolored) is shown interacting with three different parts of the p65 protein (shown in gold, blue, and light green). Credit: Mahavir Singh, Juli Feigon/UCLA Chemistry and Biochemistry

(Phys.org) -- UCLA biochemists have mapped the structure of a key proteinRNA complex that is required for the assembly of telomerase, an enzyme important in both cancer and aging.

The researchers found that a region at the end of the p65 protein that includes a flexible tail is responsible for bending telomerase's RNA backbone in order to create a scaffold for the assembly of other protein building blocks. Understanding this protein, which is found in a type of single-celled organism that lives in fresh water ponds, may help researchers predict the function of similar proteins in humans and other organisms.

The study was published June 14 in the online edition of the journal Molecular Cell and is scheduled for publication in the print edition on July 13.

The genetic code of both the single-celled protozoan Tetrahymena and humans is stored within long strands of DNA packaged neatly within chromosomes. The telomerase enzyme helps create telomeres protective caps at the ends of the chromosomes that prevent the degradation of our DNA, said Juli Feigon, a UCLA professor of chemistry and biochemistry and senior author of the study.

Each time the cell divides, the telomeres shorten, acting like the slow-burning fuse of a time bomb. After many divisions, the telomeres become eroded to a point that can trigger cell death.

Cells with abnormally high levels of telomerase activity constantly rebuild their protective chromosomal caps, allowing them to replicate indefinitely and become, essentially, immortal. Yet undying cells generally prove to be more of a curse than a blessing, Feigon said.

"Telomerase is not very active in most of our cells because we don't want them to live forever," said Feigon, who is also a researcher at UCLA's Molecular Biology Institute and a member of the National Academy of Sciences. "After many generations, DNA damage builds up and we wouldn't want to pass those errors on to subsequent cells."

Overactive telomerase has potentially lethal consequences far beyond the propagation of erroneous DNA. The enzyme is particularly lively within cancer cells, which prevents them from dying out naturally. Finding a way to turn off telomerase in cancer cells might help prevent the diseased cells from multiplying.

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Scientists discover how key enzyme involved in aging, cancer assembles

Link Between Vitamin C and Twins Can Increase Seed Production in Crops

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Discovery can assist farming of low-fertility crops, say UC Riverside biochemists

By Iqbal Pittalwala on June 18, 2012

RIVERSIDE, Calif. Biochemists at the University of California, Riverside report a new role for vitamin C in plants: promoting the production of twins and even triplets in plant seeds.

Daniel R. Gallie, a professor of biochemistry, and Zhong Chen, an associate research biochemist in the Department of Biochemistry, found that increasing the level of dehydroascorbate reductase (DHAR), a naturally occurring enzyme that recycles vitamin C in plants and animals, increases the level of the vitamin and results in the production of twin and triplet seedlings in a single seed.

The value of the discovery lies in the potential to produce genetically identical seedlings and increase production of high-value crops.

A boost of vitamin C results in the production of twin seedlings of tobacco. Photo credit: Gallie Lab, UC Riverside.

The ability to increase fertility can be extremely useful when the inherent rate of fertility is low or the value of the crop is great, such as corn in which the production of multiple embryos would significantly boost its protein content, Gallie said. The extra seedlings per seed may also enhance per-seed survival chances for some species.

Study results appear in the online international journal PLoS ONE.

Just as in humans, twins in plants can be either genetically identical or fraternal. Gallie and Chen discovered that the twins and triplets produced in tobacco plants when vitamin C was increased were true twins or triplets as they were genetically identical.

In the lab, the researchers went on to show that injecting plant ovaries with vitamin C was sufficient to produce twins or triplets and that the vitamin causes the zygote, the fertilized egg, to divide into two or even three fertilized egg cells before these cells proceed through subsequent stages of development to produce twins or triplets.

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Link Between Vitamin C and Twins Can Increase Seed Production in Crops

Stacey Nemour: The Tao of Love, Sex and Anti-Aging: Part 9

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Many of us tell ourselves that we will allow ourselves to be happy when:

A. I have X amount of dollars in the bank. B. I meet my true love/soulmate or when my partner finally wakes up and loves me the way he/she ought to. C. When I get a better job. D. When I lose weight.

The list can go on and on.

By focusing only on what we feel is lacking or what we need for our future, we put our present lives on hold or cause more delays because we are not connected to the present. The present is the future; as you read this sentence it is already one second later.

This powerful insight came to me during meditation, and it has created a huge shift in my reality. Each moment is an experience of success, so placing ourselves in the intentional knowing and understanding that we are living in the moment of success creates a continual chain of a successful life.

Doing this places us in a vibrational cycle that causes continuous experience to be a constant reflection of a life of perfection. Instead of meditating we can live the perfection by realizing the journey is the moment of perfection.

Nothing needs to happen in order for me to feel successful; I am successful right now. Nothing needs to happen in order for me to feel loved; I am loved right now. Nothing needs to happen in order to feel valid; I am valid right now.

To support a positive shift within and create harmonious relationships in personal and professional affairs:

1. Find the peaceful place inside now by not placing happiness outside yourself, which is reacting to external things. Freedom comes from creating your own reality independent of what others think or are doing.

2. Drop out of all high-drama situations. Just don't participate anymore.

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Stacey Nemour: The Tao of Love, Sex and Anti-Aging: Part 9

Medical Student Malini Daniel Elected to AMA Board of Trustees

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CHICAGO, June 18, 2012 (GLOBE NEWSWIRE) -- Malini Daniel, a medical student at the Stanford School of Medicine in Palo Alto, Calif., today became a member of the Board of Trustees of the American Medical Association (AMA), the nation's largest physician organization. Ms. Daniel was installed as a trustee at the AMA's Annual Meeting in Chicago.

"I am very honored to represent future physicians in this position on the AMA Board of Trustees," said Ms. Daniel. "As a medical student, I'm excited to share my experiences in the rapidly changing field of medicine and I look forward to working with the board to help shape the future of health care."

Ms. Daniel will complete her medical degree with a concentration in health services research and policy in 2013. She was elected by her fellow medical students to serve a one-year term on the AMA Board of Trustees.

Ms. Daniel is dedicated to supporting global health initiatives. She has done extensive policy work and research for various programs including the World Health Organization, Joint United Nations Program for HIV/AIDS and the National AIDS Control Organization for the government of India.

Malini Daniel graduated with honors in 2006 from Harvard University with a Bachelors of Arts degree in biology and international policy, later receiving a Masters of Science degree in global health science from Oxford University. She currently resides in Palo Alto.

Media Contact: Liz Magsig AMA Media Relations Office: (202) 789-7419 Newsroom: (312) 239-4991 elizabeth.magsig@ama-assn.org

About the American Medical Association (AMA) The American Medical Association helps doctors help patients by uniting physicians nationwide to work on the most important professional, public health and health policy issues. The nation's largest physician organization plays a leading role in shaping the future of medicine. For more information on the AMA, please visit http://www.ama-assn.org.

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Medical students examine business side

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By MARY SHEDDEN | The Tampa Tribune Published: June 18, 2012 Updated: June 18, 2012 - 7:00 AM

A University of South Florida medical school program highlighting leadership, empathy and business wherewithal will nearly triple its number of students this fall.

In August, 48 first-year Morsani College of Medicine students will join the 18 original participants in SELECT. The program targets students with strong self-awareness and self-management skills, as well as those showing an enhanced empathy toward patients and community.

A warning for new students: The five extra hours a week of discussions and self-reflection about communication, healthcare systems and management are intense, said first-year SELECT veteran Chris Pothering.

But these opportunities to meet with healthcare executives and other leaders make the commitment worth it, he said.

"It's almost like you forget you're in medical school when you sit down and have these interactions with people who are professionals in communication or in leadership," said Pothering, 28.

SELECT, or Scholarly Excellence, Leadership Experiences and Collaborative Training, has been brewing within the college for years. Positive feedback from the inaugural group of students and faculty mentors led to its sudden growth, said Alicia Monroe, the college's vice dean for educational affairs.

Eventually, the college will admit 56 SELECT students a year, in addition to a core medical class of 120 students. It highlights the importance in training new doctors to care for patients beyond the physical symptoms, Monroe said.

"We always have to be mindful of tasks, but also how it affects others," she said.

SELECT students often don't fall within the traditional medical admissions profile. Some of the students have other professional experience. Others have spent time in the military.

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Medical students examine business side

A New and Honest Detroit Doctor Show on WADL

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DETROIT, June 18, 2012 /PRNewswire-iReach/ --If there's one message viewers and guests alike will take away from the cutting-edge, conversational new health TV talk show, Ask Dr. Nandi, it's that "you have to be an advocate for your own care."

(Photo: http://photos.prnewswire.com/prnh/20120618/CG25914)

That's the premise behind Ask Dr. Nandi, a new talk show airing on Wednesdays on WADL. The first episodes focusing on topics like yoga, Celiac disease and childhood obesity and featuring the Detroit-based physician, Dr. Partha Nandi, aired in California to wide acclaim. Now, the show comes to his hometown.

"I want patients to know the truth about their care," says Nandi. "If you feel you're not being heard, please get another opinion. Be an advocate for your own care; this includes fighting for appropriate care from your insurance plan."

Every episode of Ask Dr. Nandi focuses on a single health problem. "We talk about a problem in detail for people so they understand it and know how to resolve it," says Nandi. "This show offers real solutions. We like to say, 'we'll go there' and we will! We are not afraid to tell the truth."

Guests include Julie Silver of Acupuncture Healthcare Associates of Michigan; fitness guru Nikki Fayne; dermatologist Dr. Wendy Sadoff; cardiologist Dr. Joel Kahn; and patient Cheryl Grossman, among other guests.

The show airs on WADL, Detroit's Channel 38, on Wednesdays at 11 a.m. Episodes will air in succession throughout the summer.

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A New and Honest Detroit Doctor Show on WADL

Why Genetically Engineered Food Is Dangerous

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Why Genetically Engineered Food Is Dangerous

New report by genetic engineers Press release for immediate release Earth Open Source 17 June 2012

LONDON, UK - Aren't critics of genetically engineered food anti-science? Isn't the debate over GMOs (genetically modified organisms) a spat between emotional but ignorant activists on one hand and rational GM-supporting scientists on the other?

A new report released today, "GMO Myths and Truths",[1] challenges these claims. The report presents a large body of peer-reviewed scientific and other authoritative evidence of the hazards to health and the environment posed by genetically engineered crops and organisms (GMOs).

Unusually, the initiative for the report came not from campaigners but from two genetic engineers who believe there are good scientific reasons to be wary of GM foods and crops.

One of the report's authors, Dr Michael Antoniou of King's College London School of Medicine in the UK, uses genetic engineering for medical applications but warns against its use in developing crops for human food and animal feed.

Dr Antoniou said: "GM crops are promoted on the basis of ambitious claims - that they are safe to eat, environmentally beneficial, increase yields, reduce reliance on pesticides, and can help solve world hunger.

"I felt what was needed was a collation of the evidence that addresses the technology from a scientific point of view.

"Research studies show that genetically modified crops have harmful effects on laboratory animals in feeding trials and on the environment during cultivation. They have increased the use of pesticides and have failed to increase yields. Our report concludes that there are safer and more effective alternatives to meeting the world's food needs."

Another author of the report, Dr John Fagan, is a former genetic engineer who in 1994 returned to the National Institutes of Health $614,000 in grant money owing to concerns about the safety and ethics of the technology. He subsequently founded a GMO testing company.

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Why Genetically Engineered Food Is Dangerous

Stars need to work on chemistry

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EvaluatePharma Analysis Provides Insight on Tomorrow’s BioPharma Landscape with Close-Up Look at NASDAQ Biotech Index

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BOSTON--(BUSINESS WIRE)--

EvaluatePharma, the premier source for pharmaceutical and biotechnology sector analysis and consensus forecasts, today released a report, titled Surveying Tomorrows BioPharma Landscape: The NASDAQ Biotech Index Up Close, which shows that the quantity of biologic drugs on the market will likely soar by 2018. A thorough analysis of companies listed on the NASDAQ Biotechnology Index (NBI) revealed that while less than 10 percent of these companies currently marketed products are biologic drugs pharmaceuticals derived from living organisms these products comprise a hefty 40 percent of the companies drug pipelines. [Note to editors: The report is available for download at http://www.evaluatepharma.com/NBI2012.%5D

The EvaluatePharma report also reveals the diversity of the 117 companies listed on the index, with insights about pipeline development and consensus sales estimates. The analysis points to a growing focus on biologics, including drugs treating cancer, infection and central nervous system diseases.

EvaluatePharma the first company to provide reliable consensus forecasts of global drug sales developed the report to give investors and the life science community at large a better understanding of the products and trends driving the index.

The NASDAQ Biotech Index is cited all around the world, but rarely do we see a detailed aggregate analysis of these leading, publicly traded biotechnology companies. This analysis provides insight into the breadth and scope of todays products and looks at where this dynamic sector is heading.

Among the reports key takeaways:

Access the complete report online. A PDF version is available at http://www.evaluatepharma.com/NBI2012.

About EvaluatePharma

Since 1996, EvaluatePharma has been the premier source for pharmaceutical and biotechnology sector analysis, delivering exclusive, trusted commercial insight into industry performance through its proprietary platform. EvaluatePharma is staffed by a team of 75 dedicated healthcare analysts employing rigorous methodologies to collate, organize and deliver the most-up-to-date commercial performance data available. An award winning editorial team of journalists writing under the EP Vantage name support EvaluatePharmas analysis, and enable the life science community to make sound business decisions about value and opportunity. For more information please visit http://www.evaluatepharma.com.

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EvaluatePharma Analysis Provides Insight on Tomorrow’s BioPharma Landscape with Close-Up Look at NASDAQ Biotech Index

Anatomy of a Drug Manufacturing Plant (Last in a Three-Part Series Examining the Financial Impact of New Plant …

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SUGAR LAND, TX--(Marketwire -06/18/12)- Reported by Annette Kreuger for Industrial Information Resources Sugar Land, Texas) -- Once construction has wrapped up and the validation process for a new pharmaceutical or biotech (pharma-bio) plant is complete, it is time to begin production. Not only does an operational plant manufacture drug products that improve the public's physical health, but it also sets off a ripple effect that is beneficial to the financial well being of the host community, county and state.

In the past 12-month period (6/2011-6/2012), 83 new Pharmaceutical & Biotech Industry plants began operations in North America. Industrial Info is tracking 185 additional new-build (or lease and equip) projects in various stages of planning, engineering or construction.

For details, view the entire article by subscribing to Industrial Info's Premium Industry News at http://www.industrialinfo.com/showAbstract.jsp?newsitemID=224180&refer=mw, or browse other breaking industrial news stories at http://www.industrialinfo.com.

Industrial Info Resources (IIR), with global headquarters in Sugar Land, Texas, and eight offices outside of North America, is the leading provider of global market intelligence specializing in the industrial process, heavy manufacturing and energy markets. Industrial Info's quality-assurance philosophy, the Living Forward Reporting Principle, provides up-to-the-minute intelligence on what's happening now, while constantly keeping track of future opportunities. To contact an office in your area, visit the http://www.industrialinfo.com "Contact Us" page.

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Anatomy of a Drug Manufacturing Plant (Last in a Three-Part Series Examining the Financial Impact of New Plant ...

Names and Faces

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Today's most viewed articles Donatello receives AMA fellowship

KITTERY, Maine Dr. Jeff Donatello recently received a fellowship in Integrative Cancer Therapies from the American Academy of Anti-Aging Medicine.

The fellowship is sponsored by the American Medical Association through the South Florida School of Medicine. Donatello is now among a select group of 300 doctors and health care professionals who utilize proven therapies beyond chemotherapy and radiation to help people with cancer to regain and maintain their health.

Donatello's office is at 76 Route 1 Bypass in Kittery. For information, visit donatellobbt.com. For appointments, call (207) 438-9339.

PORTSMOUTH Piscataqua Savings Bank has announced the addition of three new members to its board of corporators.

The corporators represent individuals from the community asked to serve in an oversight capacity for the bank. The new members are: Philip L. Pettis, partner with the law firm of Boynton, Waldron, Doleac, Woodman and Scott in Portsmouth; Gregory C. Johnson, CFA, principal with Prime, Bucholtz and Associates, with offices in Portsmouth, Boston and Atlanta, Ga.; and Richard G. Kaiser, vice president/senior trust officer at Piscataqua Savings Bank.

The corporators annually elect the board of trustees and ensure the bank operates in the best interest of its customers and the community. At its recent annual meeting, corporators elected the following individuals to the board of trustees: Michael J. Asselin, Kenneth R. Clark, Jay S. Gibson, Charles A. Griffin, Ann H. Peters, Barbara Shea-Smucker, Vincent Taccetta III and Richard M. Wallis.

For information, visit http://www.piscataqua.com.

PORTSMOUTH Chambers and Partners, a London-based research organization, bestowed top rankings on Pierce Atwood LLP and its lawyers as part of law firm rankings that the research group released recently.

Pierce Atwood has a total of 40 lawyers recognized in the 2012 guide, Chambers USA: America's Leading Lawyers for Business. The firm's New Hampshire office in Portsmouth has two honorees named in the guide: Scott E. Pueschel, P.C., in the corporate/commercial area and Denis O. Robinson in the real estate area.

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Names and Faces

Names and Faces

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Today's most viewed articles Donatello receives AMA fellowship

KITTERY, Maine Dr. Jeff Donatello recently received a fellowship in Integrative Cancer Therapies from the American Academy of Anti-Aging Medicine.

The fellowship is sponsored by the American Medical Association through the South Florida School of Medicine. Donatello is now among a select group of 300 doctors and health care professionals who utilize proven therapies beyond chemotherapy and radiation to help people with cancer to regain and maintain their health.

Donatello's office is at 76 Route 1 Bypass in Kittery. For information, visit donatellobbt.com. For appointments, call (207) 438-9339.

PORTSMOUTH Piscataqua Savings Bank has announced the addition of three new members to its board of corporators.

The corporators represent individuals from the community asked to serve in an oversight capacity for the bank. The new members are: Philip L. Pettis, partner with the law firm of Boynton, Waldron, Doleac, Woodman and Scott in Portsmouth; Gregory C. Johnson, CFA, principal with Prime, Bucholtz and Associates, with offices in Portsmouth, Boston and Atlanta, Ga.; and Richard G. Kaiser, vice president/senior trust officer at Piscataqua Savings Bank.

The corporators annually elect the board of trustees and ensure the bank operates in the best interest of its customers and the community. At its recent annual meeting, corporators elected the following individuals to the board of trustees: Michael J. Asselin, Kenneth R. Clark, Jay S. Gibson, Charles A. Griffin, Ann H. Peters, Barbara Shea-Smucker, Vincent Taccetta III and Richard M. Wallis.

For information, visit http://www.piscataqua.com.

PORTSMOUTH Chambers and Partners, a London-based research organization, bestowed top rankings on Pierce Atwood LLP and its lawyers as part of law firm rankings that the research group released recently.

Pierce Atwood has a total of 40 lawyers recognized in the 2012 guide, Chambers USA: America's Leading Lawyers for Business. The firm's New Hampshire office in Portsmouth has two honorees named in the guide: Scott E. Pueschel, P.C., in the corporate/commercial area and Denis O. Robinson in the real estate area.

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Names and Faces

TOP 10: Readers' travel pics from across the world!

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We invited you to share pictures from your travels with us on Rediff ZaraBol. Here is a fresh batch of pictures that you posted.

From Haridwar to Andaman to Mt Kilimanjaro and beyond, readers responded to our invite and posted their travel pictures on Rediff ZaraBol in

Sourav Chattaraj shares this picture of the Bholagiri Ashram in Haridwar.

Click here to upload your travel pictures on Rediff ZaraBol! Post a description of your photo (eg where it was taken, when etc) in less than 140 characters and we will publish your pictures right here on Rediff.com and India Abroad.

Disclaimer: The photographs featured in this series are, to the best of our knowledge, original entries submitted by readers. Rediff.com does not assume any responsibility for their originality.

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TOP 10: Readers' travel pics from across the world!

Jetset to jettison jobs as profit falls short

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Jetset plans job cuts after it missed profit goals.

Jetset Travelworld, the travel group partly owned by Qantas, will axe about 110 jobs - more than half of which will be from its travel management business - and report a smaller annual profit.

The travel retailer, whose brands include Harvey World Travel and Qantas Business Travel, warned today that its pre-tax profit this financial year will be less than the $30.7 million it reported in 2010-11 because of one-off restructuring and impairment charges.

The tightly held stock was unchanged at 35 cents early today, leaving its market value at just half of what it was at the start of the year.

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Qantas is the largest shareholder in Jetset with a 29 per cent stake, while CVC Asia Pacific and UBS have holdings of 27 per cent and 18 per cent respectively.

The brunt of the changes announced today will be felt by its travel management division, which will lose about 66 of the 110 jobs to be cut across Jetset's businesses.

The majority of the other jobs to be axed will be from its wholesale travel division.

Jetset began a review of its businesses in late April when it warned of a softening in demand for travel in March and April, which are among what is traditionally its busiest trading period.

Annual savings

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Jetset to jettison jobs as profit falls short

Supermicro® FatTwinâ„¢ Takes Center Stage at International Supercomputing Conference 2012

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- New 4U, 8/4 Node FatTwin Joins Supermicros SuperBlade, GPU Platforms, SuperWorkstation, 4-Way and Twin Architecture Solutions Highlighting Supermicros Supercomputing Solutions for HPC

HAMBURG, Germany, June 18, 2012 /PRNewswire/ -- Super Micro Computer, Inc., a global leader in high-performance, high-efficiency server technology and green computing, will debut its newest innovative architecture, FatTwin [http://www.supermicro.com/FatTwin] at ISC, giving the public its first hands-on look at the future of power-efficient supercomputing. The FatTwin is a new 4U high-performance, high-capacity platform that offers versatile configurations for HPC with multi-node models that support dual 135W Intel Xeon E5-2600 processors, up to 8 hot-swap 3.5" HDDs in 1U and up to 8 GPUs in 2U. This new architecture is also designed to operate in high ambient temperatures providing greater performance while reducing cooling infrastructure costs.

(Photo: http://photos.prnewswire.com/prnh/20120618/AQ25859-INFO [http://photos.prnewswire.com/prnh/20120618/AQ25859-INFO])

"Many factors affect the successful implementation of scalable supercomputing solutions, and obtaining maximum performance within budget and power constraints is the most challenging task, " said Charles Liang, President and CEO of Supermicro. "At Supermicro, we emphasize not only the highest-performance in our HPC solutions, but also the overall energy efficiency and optimal power-usage effectiveness (PUE) of our complete systems. Supermicros new architectures such as FatTwin integrate the latest CPU, GPU and storage technologies with advanced high-efficiency digital switching power supplies and free-air cooling designs for maximum performance and increased operational temperature ranges up to 47 degrees C that eliminate costly air conditioning. Our expertise in server design and thermal management reduces our customers TCO and offsets operating expenses providing more budget for mission critical compute performance."

Supermicros new FatTwin expands on their widely adopted 1U and 2U Twin SuperServer lines and adds a new series of 4U systems that offers the industrys best capacity and efficiency in a standard 19" rack ready solution. The FatTwin is now shipping in high-compute density 4U 8 and 4 node configurations supporting dual Intel Xeon E5-2600 processors, up to 512GB of 1600MHz memory and up to 12 hot-swap 2.5" SAS/SATA HDDs per U in the 8 node or up to 8 hot-swap 3.5" SAS/SATA HDDs per U in the 4 node configuration. These systems also offer PCI-E 3.0 expandability and optional 56Gbps ConnectX-3 FDR InfiniBand or 10GbE connectivity. The real highlights of these systems reach beyond their high-performance and capacity with an earth friendly focus on energy efficiency and resulting cost savings. The FatTwin is designed to operate in extreme ambient temperature range (0 degrees C to 47 degrees C), free-air cooled environments, effectively eliminating the need for costly air-conditioning. The Twin architecture based multi-node solutions feature shared power and cooling resources reducing costly components and cabling, resulting in optimized air-flow and maximizing energy utilization. Combined with Supermicros redundant Platinum Level high-efficiency (95%+) digital switching power supplies, the FatTwin delivers maximum compute density and energy efficiency for todays most demanding supercomputing needs. FatTwin is a versatile platform and additional models will be released in early Q3 2012 offering solutions optimized for GPU supercomputing and Big Data/Hadoop analytics.

Exhibits at the show include Supermicros wide range of X9 Intel Xeon E5-2600 based platforms optimized for HPC. SuperBlade [http://www.supermicro.com/products/SuperBlade/] offers various blade configurations with a 56Gb FDR InfiniBand switch for high-speed interconnectivity. The GPU Blade SBI-7127RG [http://www.supermicro.com/servers/blade/module/SBI-7127RG.cfm] provides the highest compute density with 20 GPUs and 20 CPUs in 7U and the double-density TwinBlade SBI-7227R-T2 [http://www.supermicro.com/products/nfo/Xeon_X9_E5.cfm?pg=SB] provides 20 DP (dual-processor) server nodes with 40 CPUs in 7U. The SYS-1027GR-TQFT [http://www.supermicro.com/products/system/1u/1027/sys-1027gr-tqft.cfm] offers an extreme 4 GPUs in 1U and the 2U 6 GPU SYS-2027GR-TRF [http://www.supermicro.com/products/system/2u/2027/sys-2027gr-trf.cfm] is ideal for scalable cluster computing. The SYS-7047GR-TRF [http://www.supermicro.com/products/nfo/Maximus.cfm] SuperWorkstation accommodates up to 5 GPUs and recently received NVIDIA Maximus certification making this system a powerhouse for engineering, design and simulation applications. Supermicros advanced 4-Way MP (multi-processor) systems targeting mission-critical, data-intensive applications will be represented with the SYS-8047R-7RFT+ [http://www.supermicro.com/products/system/4u/8047/sys-8047r-7rft_.cfm].

In addition Supermicro will display its A+ line of AMD Opteron 6000 servers including the 4U rack mountable quad-processor AS-4042G-TRF [http://www.supermicro.com/aplus/system/tower/4042/as-4042g-trf.cfm] and the 2U Twin(2) AS-2022TG-H6IBQRF [http://www.supermicro.com/aplus/system/2u/2022/as-2022tg-h6ibqrf.cfm] offering four hot-pluggable dual-processor 16/12/8-Core nodes in a 2U form factor. Supermicro A+ Blade solutions include the 4-Way SuperBlade SBA-7142G-T4 [http://www.supermicro.com/Aplus/superblade/module/SBA-7142G-T4.cfm] with ten hot-pluggable quad-processor 16/12/8-Core nodes in a 7U blade enclosure and the double-density TwinBlade SBA-7222G-T2 [http://www.supermicro.com/Aplus/superblade/module/SBA-7222G-T2.cfm] with 20 DP 16/12/8-Core nodes in a 7U blade enclosure. Supermicro offers complete computing solutions with its 10G/1G Ethernet switches including two new models that also support free-air cooling operation in ambient temperatures of up to 47 degrees C.

Visit Supermicro at ISC12 in Hamburg, Germany at the Congress Center Hamburg (CCH), booth #520 or browse Supermicros total line of high performance, high-efficiency server and storage solutions at http://www.supermicro.com [http://www.supermicro.com/].

About Super Micro Computer, Inc.

Supermicro , the leading innovator in high-performance, high-efficiency server technology is a premier provider of advanced server Building Block Solutions for Data Center, Cloud Computing, HPC, Enterprise IT and Embedded Systems worldwide. Supermicro is committed to protecting the environment through its "We Keep IT Green" initiative and provides customers with the most energy-efficient, environmentally-friendly solutions available on the market.

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Supermicro® FatTwinâ„¢ Takes Center Stage at International Supercomputing Conference 2012

Supermicro(R) FatTwin(TM) Takes Center Stage at International Supercomputing Conference 2012

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New 4U, 8/4 Node FatTwin(TM) Joins Supermicro's SuperBlade(R), GPU Platforms, SuperWorkstation, 4-Way and Twin Architecture Solutions Highlighting Supermicro's Supercomputing Solutions for HPC

HAMBURG, Germany, June 18, 2012 /PRNewswire-Asia/ -- Super Micro Computer, Inc. (SMCI), a global leader in high-performance, high-efficiency server technology and green computing, will debut its newest innovative architecture, FatTwin(TM)( http://www.supermicro.com/FatTwin ) at ISC, giving the public its first hands-on look at the future of power-efficient supercomputing. The FatTwin is a new 4U high-performance, high-capacity platform that offers versatile configurations for HPC with multi-node models that support dual 135W Intel(R) Xeon(R) E5-2600 processors, up to 8 hot-swap 3.5" HDDs in 1U and up to 8 GPUs in 2U. This new architecture is also designed to operate in high ambient temperatures providing greater performance while reducing cooling infrastructure costs.

(Photo: http://photos.prnewswire.com/prnh/20120618/AQ25859-INFO)

"Many factors affect the successful implementation of scalable supercomputing solutions, and obtaining maximum performance within budget and power constraints is the most challenging task," said Charles Liang, President and CEO of Supermicro. "At Supermicro, we emphasize not only the highest-performance in our HPC solutions, but also the overall energy efficiency and optimal power-usage effectiveness (PUE) of our complete systems. Supermicro's new architectures such as FatTwin integrate the latest CPU, GPU and storage technologies with advanced high-efficiency digital switching power supplies and free-air cooling designs for maximum performance and increased operational temperature ranges up to 47 degrees C that eliminate costly air conditioning. Our expertise in server design and thermal management reduces our customer's TCO and offsets operating expenses providing more budget for mission critical compute performance."

Supermicro's new FatTwin expands on their widely adopted 1U and 2U Twin SuperServer lines and adds a new series of 4U systems that offers the industry's best capacity and efficiency in a standard 19" rack ready solution. The FatTwin is now shipping in high-compute density 4U 8 and 4 node configurations supporting dual Intel(R) Xeon(R) E5-2600 processors, up to 512GB of 1600MHz memory and up to 12 hot-swap 2.5" SAS/SATA HDDs per U in the 8 node or up to 8 hot-swap 3.5" SAS/SATA HDDs per U in the 4 node configuration. These systems also offer PCI-E 3.0 expandability and optional 56Gbps ConnectX-3 FDR InfiniBand or 10GbE connectivity. The real highlights of these systems reach beyond their high-performance and capacity with an earth friendly focus on energy efficiency and resulting cost savings. The FatTwin is designed to operate in extreme ambient temperature range (0 degrees C to 47 degrees C), free-air cooled environments, effectively eliminating the need for costly air-conditioning. The Twin architecture based multi-node solutions feature shared power and cooling resources reducing costly components and cabling, resulting in optimized air-flow and maximizing energy utilization. Combined with Supermicro's redundant Platinum Level high-efficiency (95%+) digital switching power supplies, the FatTwin delivers maximum compute density and energy efficiency for today's most demanding supercomputing needs. FatTwin is a versatile platform and additional models will be released in early Q3 2012 offering solutions optimized for GPU supercomputing and Big Data/Hadoop analytics.

Exhibits at the show include Supermicro's wide range of X9 Intel(R) Xeon(R) E5-2600 based platforms optimized for HPC. SuperBlade(R)( http://www.supermicro.com/products/SuperBlade ) offers various blade configurations with a 56Gb FDR InfiniBand switch for high-speed interconnectivity. The GPU Blade SBI-7127RG( http://www.supermicro.com/servers/blade/module/SBI-7127RG.cfm ) provides the highest compute density with 20 GPUs and 20 CPUs in 7U and the double-density TwinBlade(R) SBI-7227R-T2( http://www.supermicro.com/products/nfo/Xeon_X9_E5.cfm?pg=SB ) provides 20 DP (dual-processor) server nodes with 40 CPUs in 7U. The SYS-1027GR-TQFT( http://www.supermicro.com/products/system/1u/1027/sys-1027gr-tqft.cfm ) offers an extreme 4 GPUs in 1U and the 2U 6 GPU SYS-2027GR-TRF( http://www.supermicro.com/products/system/2u/2027/sys-2027gr-trf.cfm ) is ideal for scalable cluster computing. The SYS-7047GR-TRF( http://www.supermicro.com/products/nfo/Maximus.cfm ) SuperWorkstation accommodates up to 5 GPUs and recently received NVIDIA(R) Maximus(TM) certification making this system a powerhouse for engineering, design and simulation applications. Supermicro's advanced 4-Way MP (multi-processor) systems targeting mission-critical, data-intensive applications will be represented with the SYS-8047R-7RFT+( http://www.supermicro.com/products/system/4u/8047/sys-8047r-7rft_.cfm ).

In addition Supermicro will display its A+ line of AMD Opteron(TM) 6000 servers including the 4U rack mountable quad-processor AS-4042G-TRF( http://www.supermicro.com/aplus/system/tower/4042/as-4042g-trf.cfm ) and the 2U Twin(2)(R) AS-2022TG-H6IBQRF( http://www.supermicro.com/aplus/system/2u/2022/as-2022tg-h6ibqrf.cfm ) offering four hot-pluggable dual-processor 16/12/8-Core nodes in a 2U form factor. Supermicro A+ Blade solutions include the 4-Way SuperBlade SBA-7142G-T4( http://www.supermicro.com/Aplus/superblade/module/SBA-7142G-T4.cfm ) with ten hot-pluggable quad-processor 16/12/8-Core nodes in a 7U blade enclosure and the double-density TwinBlade SBA-7222G-T2( http://www.supermicro.com/Aplus/superblade/module/SBA-7222G-T2.cfm ) with 20 DP 16/12/8-Core nodes in a 7U blade enclosure. Supermicro offers complete computing solutions with its 10G/1G Ethernet switches including two new models that also support free-air cooling operation in ambient temperatures of up to 47 degrees C.

Visit Supermicro at ISC'12 in Hamburg, Germany at the Congress Center Hamburg (CCH), booth #520 or browse Supermicro's total line of high performance, high-efficiency server and storage solutions at http://www.supermicro.com.

About Super Micro Computer, Inc.

Supermicro(R) (SMCI), the leading innovator in high-performance, high-efficiency server technology is a premier provider of advanced server Building Block Solutions(R) for Data Center, Cloud Computing, HPC, Enterprise IT and Embedded Systems worldwide. Supermicro is committed to protecting the environment through its "We Keep IT Green(R)" initiative and provides customers with the most energy-efficient, environmentally-friendly solutions available on the market.

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Supermicro(R) FatTwin(TM) Takes Center Stage at International Supercomputing Conference 2012

The machine is real

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"Person of Interest" the CBS cop drama about a government super computer that can predict the victims and perpetrators of crime may not be so far fetched, after all.

The government has been trying to build exactly the kind of machine that we feature on the show for about a decade now, producer Jonathan Nolan says.

And now, it appears to have succeeded.

The National Security Agency is in the process of constructing a $2 billion data processing and spy center in remote Bluffdale, Utah, according to a recent report.

When completed next year, the one-million-square-foot facility will be used to intercept, store and analyze everything from private e-mails and cellphone calls to Web searches and parking tickets.

I SPY: Harold Finch (Michael Emerson) quits his job when he realizes the machine he made will be used for illegal surveillance.

The no-longer secret project first exposed by the tech magazine Wired in March is an apparent realization of the Total Information Awareness project proposed by the Bush White House in the months following 9/11.

TIA was nixed by Congress in 2003 amid fears of invading the privacy of ordinary Americans.

Person of Interest which producers like to call science fact is based on the idea that a version of the cyber-surveillance system was actually built and is now being used secretly by its designer to prevent violent crimes on the streets of New York.

The show, the top-rated new drama of last season, was a near-instant hit when it debuted last fall.

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The machine is real