Vector Aerospace Signs Engine Services Agreement with Pascan Express

Toronto, ON Vector Aerospace Corporation (www.vectoraerospace.com), a global independent provider of aviation maintenance, repair and overhaul (MRO) services is pleased to announce that Vector Aerospace Engine Services-Atlantic, Inc. (Vector) has entered into a Service Agreement with Pascan Express located in Quebec City, Quebec.

As per the terms of the three-year exclusive agreement, Vector provides Pascan Express with comprehensive fixed-wing aircraft engine repair and overhaul support from its Vector-Atlantic facility, located in Prince Edward Island, Canada.

Pierre Piotte, vice president of maintenance for Pascan Express says, As an operator of two ATR42 aircraft, Pascan Express takes pride in its reputation as a trusted flight services provider. We are confident that this new partnership with Vector will allow our company to focus on being a trusted airline operator, knowing that Vector will provide exceptional repair and overhaul service for our fleet of engines."

The signing of the agreement represents another significant achievement for Vector Aerospace Engine Services Atlantic, which is a Pratt and Whitney Canada (P&WC) Designated Overhaul Facility (DOF). Jeff Poirier, president of Vector Aerospace Engine Services Atlantic says, Our comprehensive P&WC approved engine and component repair, overhaul and test services will be of great value and benefit to Pascan Express and their customers. We have the experience and expertise to deliver industry-leading customer service and we will strive to exceed Pascan's expectations.

Poirier elaborates on the specifics of the agreement, explaining that the terms include various repair, hot section inspections, modifications, overhaul and test support for Pascans current fleet of two ATR-42 Aircraft including the P&WC PW120 Series Engine with plans to expand their fleet up to twelve ATR-42s within the next two years.

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Vector Aerospace Signs Engine Services Agreement with Pascan Express

PASSUR® Aerospace Reports 118% Increase in Net Income for First Half of FY2012

STAMFORD, Conn., June 20, 2012 /PRNewswire/ -- PASSUR Aerospace, Inc. (PSSR.PK), a business intelligence software and solutions company, reported that revenues for the first six months of fiscal 2012 increased 2%, to $6,996,000 compared to $6,875,000 in the same period of the previous fiscal year. For the same period, the Company's net income increased 118% to $939,000 or $.12 per diluted share, compared to net income of $432,000 or $.08 per share, significantly as a result of reduced interest costs.

Total revenues for the quarter ended April 30, 2012 increased 5% to $3,532,000, compared to $3,365,000 in the same quarter of the previous fiscal year. The Company had net income of $559,000 or $.07 per diluted share in the second quarter ended April 30, 2012, compared to a net income of $122,000 or $.02 per diluted share in the same quarter of fiscal 2011.

"We're encouraged, but not satisfied with the increase in sales and profitability, and we're particularly pleased with the market acceptance of the PASSUR Integrated Traffic Management platform (PITM)," said Jim Barry, President and CEO of PASSUR Aerospace. "As part of the ongoing investment in PITM, we announced the launch of the Airport Information Network - a new module to PITM where all stakeholders can coordinate information, situational awareness, and actions to manage congestion, diversions, and tarmac delays at the regional and national level. A joint effort between PASSUR, airlines, and airports, AIN is an industry response to the challenge of systemic disruptions which are so costly, financially and environmentally, disruptive to the passenger experience - and which can only be solved on a collaborative basis."

"We continue to make the investments needed to take advantage of what we see as a significant opportunity for long-term, robust growth," said G.S. Beckwith Gilbert, PASSUR Aerospace Chairman of the Board.

About PASSUR Aerospace

PASSUR Aerospace, Inc. is a business intelligence company that provides predictive analytics built on proprietary algorithms and the concurrent integration and simultaneous mining of multiple databases. We believe PASSUR is the industry standard in business intelligence dashboards and predictive analytics for aviation organizations. PASSUR serves dozens of airlines (including six of the top eight North American airlines, and all five of the top hub carriers), approximately 60 airport customers (including 23 of the top 30 North American airports), and approximately 200 corporate aviation customers, as well as the U.S. government, including the Federal Aviation Administration (FAA) and the Transportation Security Administration (TSA). PASSUR's system provides coast-to-coast coverage and is driven by proprietary, patented, business intelligence software, which is powered by a unique North American network of 155 passive radars, company owned. Supplementary, detailed coverage is also provided at 98 of the top 100 North American airports. Other PASSURs are located in Europe and Asia. Flight tracks are updated between 1 and 4.6 seconds, thereby making available a system which is user-friendly and useful for decision-making. Visit PASSUR Aerospace's website at http://www.passur.comfor updated news, products, and solutions.

The forward-looking statements in this press release relating to management's expectations and beliefs are based on preliminary information and management assumptions. Such forward-looking statements are subject to a wide range of risks and uncertainties that could cause results to differ in material respects, including those related to customer needs, budgetary constraints, competitive pressures, the success of airline trials, the profitable use of the Company's owned PASSURs located at major airports, the Company's maintenance of above average quality of its product and services, as well as potential regulatory changes. Further information regarding factors that could affect the Company's results is contained in the Company's SEC filings, including the October 31, 2011 Form 10-K and April 30, 2012 Form 10-Q.

Contact:

James T. Barry President & CEO (203) 622-4086 jimbarry@passur.com

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PASSUR® Aerospace Reports 118% Increase in Net Income for First Half of FY2012

Align Aerospace Receives Top FACC Supplier Award

CHATSWORTH, Calif., June20, 2012 /PRNewswire/ --Align Aerospace, a leading global provider of hardware, components, logistics and supply chain solutions in the global aerospace and defense industries, announced today that its Collegien, Paris, France office has earned the prestigious Excellent Supplier Award 2011 in Gold from Austrian aviation supplier FACC AG for "exceptional commitment and exemplary performance."

FACC presents the annual award in gold, silver and bronze to recognize three suppliers for exceptional commitment and exemplary performance in continually providing high-quality products and reliable adherence to delivery requirements. Other factors considered include customer service, flexibility, cooperation, and willingness to develop, accept and implement cost-saving and process-optimizing measures. With the coveted Excellent Supplier Awards, FACC publicly recognizes and rewards optimum suppliers within its own supply chain, identifying those who are totally dependable, trustworthy and contribute greatly towards its ultimate goal of Total Customer Satisfaction.

"This is a tremendous honor for Align Aerospace and our team in Europe, especially as FACC is a key customer and a leading producer and designer of composite parts for aviation applications," said Align's CEO Richard C. Organ."This is a great example of how our global supply network and service offerings help our customers to be more competitive."

About Align:

Align Aerospace is a leading supplier of hardware and related components to a broad range of aerospace and defense OEMs and their subcontractors throughout the world. Experts in bid-to-buy, JIT, VMI, lean manufacturing and supply chain management, Align has more than 90,000 unique parts in stock from over 2,000 suppliers ready to ship from its warehouses throughout the U.S. and Europe. Between 1998 and 2011, the Company operated as Pentacon, Eurofast SAS, and Anixter Aerospace Hardware. Align began independent operations in August 2011 as a result of the divestiture of the business by Anixter International to Greenbrier Equity Group.

About FACC

FACC AG is one of the world's leading companies in the development and production of advanced fiber-reinforced composite components and systems for the aviation industry. Its range of products reaches from structural components for the fuselage and wings to engine components to complete passenger cabins for passenger planes and helicopters. FACC is a supplier to all large aircraft manufacturers such as Airbus, Boeing, Bombardier, Embraer, COMAC and Sukhoi as well as engine manufacturers and sub-suppliers of OEMs.

http://www.alignaero.com

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Align Aerospace Receives Top FACC Supplier Award

Chemist explores nanotechnology in search of cheaper solar cells

(Phys.org) -- Luke Hanley is a big believer in harnessing solar energy to produce electricity. Doing it more efficiently is his goal.

"If you could make solar cells cheaper and more efficient, then you could think about putting them on a much wider variety of surfaces," said Hanley, professor and head of chemistry at the University of Illinois at Chicago.

"There's only a certain amount of energy that falls from the sun per square meter. You can't increase that amount of energy, but you can make it less expensive to capture it," he said.

Hanley received a $390,000 grant from the National Science Foundation to test methods of coating solar panel films using nanoparticles from a chemical group called metal chalcogenides. The inexpensive films could be wrapped over everything from vehicles to buildings to gain maximum sunshine exposure and produce electricity.

Chalcogenides are fairly abundant, relatively cheap, and don't contain toxic elements like cadmium or tellurium, which are often used in solar cells.

"Using less expensive, less toxic materials -- and using processes where you could coat inexpensively and not use much of the material -- could make these solar cells more viable," Hanley said.

Working with Igor Bolotin, research assistant professor of chemistry, and graduate students Mike Majeski and Doug Pleticha, Hanley developed a method for depositing metal chalcogenide nanoparticles by cluster beam deposition. The process uses a magnetically confined electrical discharge of argon gas ions to knock metal atoms into the gas phase and react with hydrogen sulfide or hydrogen selenide. The metal-sulfide or metal-selenide then condenses into nano-sized clusters that land on a surface to produce the film.

"If you can do everything from the gaseous deposition stage, you might make the process less expensive, Hanley said. You also may make a novel material that has a better efficiency."

Hanley and his coworkers will evaluate the electrical properties of these new films and study how they respond to light. He thinks that using different chemicals for nanoparticle-embedded solar films could create new products some two to three times more efficient than products now on the market, making solar energy more competitive.

But Hanley noted there are other factors to consider besides price.

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Chemist explores nanotechnology in search of cheaper solar cells

Taming light with graphene

ScienceDaily (June 20, 2012) Scientists have visualized the trapping and confinement of light on graphene, making a sheet of carbon atoms the most promising candidate for optical information processing on the nano-scale, optical detection, and ultrafast optoelectronics.

Spanish research groups have achieved the first ever visualizations of light guided with nanometric precision on graphene (a one-atom-thick sheet of carbon atoms). This visualization demonstrates what theoretical physicists have long predicted; that it is possible to trap and manipulate light in a highly efficient way, using graphene as a novel platform for optical information processing and sensing. Synergies between theoretical proposals from IQFR-CSIC (Madrid), specializations in graphene nano-photonics and nano-optoelectonics at ICFO (Barcelona), and experimental expertise in optical nano-imaging at nanoGUNE (San Sebastian) give rise to these noteworthy results reported in Nature this week in a back-to-back publication alongside a similar study by the group of Dmitry Basov in UCSD in California.

Graphene is a material that, among many other fascinating properties, has an extraordinary optical behavior. Particularly interesting optical properties had been predicted for the case that light couples to so-called plasmons, wave-like excitations that were predicted to exist in the "sea" of conduction electrons of graphene. However, no direct experimental evidence of plasmons in graphene had been shown up to this work. This is because the wavelength of graphene plasmons is 10 to 100 times smaller than what can be seen with conventional light microscopes.

Now, the researchers show the first experimental images of graphene plasmons. They used a so called near-field microscope that uses a sharp tip to convert the illumination light into a nanoscale light spot that provides the extra push needed for the plasmons to be created. At the same time the tip probes the presence of plasmons. Rainer Hillenbrand, leader of the nanoGUNE group comments: "Seeing is believing! Our near-field optical images definitely proof the existence of propagating and localized graphene plasmons and allow for a direct measurement of their dramatically reduced wavelength."

As demonstrated by the researchers, graphene plasmons can be used to electrically control light in a similar fashion as is traditionally achieved with electrons in a transistor. These capabilities, which until now were impossible with other existing plasmonic materials, enable new highly efficient nano-scale optical switches which can perform calculations using light instead of electricity.

"With our work we show that graphene is an excellent choice for solving the long-standing and technologically important problem of modulating light at the speeds of today's microchips," says Javier Garca de Abajo, leader of the IQFR-CSIC group. In addition, the capability of trapping light in very small volumes could give rise to a new generation of nano-sensors with applications in diverse areas such as medicine and bio-detection, solar cells and light detectors, as well as quantum information processing. This result literally opens a new field of research and provides a first viable path towards ultrafast tuning of light, which was not possible until now. Frank Koppens, leader of the ICFO group, summarizes: "Graphene is a novel and unique material for plasmonics, truly bridging the fields of nano-electronics and nano-optics."

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Taming light with graphene

Editorial: Davis medical school was way out of bounds

University of California, Davis, medical school professor Michael Wilkes doesn't shy from controversial positions, or criticism of the university where he teaches.

That's how how First Amendment free speech rights work.

That's also how academic freedom works, a bedrock principle that criticism and open competition among ideas are the "surest safeguard of truth," wrote the American Association of Universities in 1953.

But First Amendment and academic freedom principles are under challenge at the medical school.

When Wilkes penned an op-ed column in 2010, he received a document on letterhead from legal counsel, requested by UC Davis School of Medicine Dean Claire Pomeroy, saying the university could potentially sue him for defamation for hurting the reputation of the university.

That is outrageous and calls for action by Chancellor Linda Katehi.

Just what drew that overwrought response from the medical school?

Wilkes, a recognized expert on prostate cancer, co-authored an op-ed piece with a USC professor. Published in the San Francisco Chronicle, it said prostate screening not only may do no good, it may be harmful and lambasted a UC Davis men's health seminar advertising "Prostate Defense Begins at 40."

The authors labeled the seminar an "infomercial endorsement" of prostate screening: "We can't say why UC Davis offers this course that ignores scientific evidence, but we wonder whether it just might have to do with money."

Wilkes has been outspoken in questioning marketing by medical industries in Bee columns, too.

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Editorial: Davis medical school was way out of bounds

Cycling: Geraint Thomas in pursuit of Olympic track gold

As Bradley Wiggins and Mark Cavendish seek cycling immortality on the roads of France next month, Geraint Thomas will be riding around in circles in Manchester. But the 26-year-old from Cardiff would have it no other way.

Thomas has proven himself to be a versatile and leading talent on the bike, including this season as team-mate Wiggins has won three stage races, with the Welshman providing support at Paris-Nice and the Tour de Romandie as the Londoner proved his credentials as a potential Tour de France champion.

Rather than support Wiggins in the mountains and Cavendish in the sprints when the Tour begins in Liege on June 30, Thomas will instead focus on fine-tuning preparations for success in the four-kilometre team pursuit at a second successive Olympics.

Beijing gold medal winner Thomas told Press Association Sport: Theres no doubt at all, but Id love to have been going to France to help them both out.

Its just unfortunate where the Olympics and Tour falls in the year.

I was always going to come back and ride the team pursuit. A home Olympics is massive and its my best chance of winning a gold medal. Its always been like that.

The team pursuit really excites me and its something I love doing. I just cant wait to get on those boards in London now and rip it up.

Thomas completed the Giro dItalia alongside Team Sky colleague Pete Kennaugh and the duo were both named in the Great Britain Olympic team earlier this month, with Ed Clancy, Steven Burke and Andy Tennant completing the team pursuit squad.

All five have been riding on the road in the last few weeks but recently returned to the track for the first time since winning the World Championships in Melbourne in April.

The British team set a world record of three minutes 53.295 seconds there, going faster than the Beijing-winning mark.

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Cycling: Geraint Thomas in pursuit of Olympic track gold

Storage company promises INFINITE IMMORTALITY

NetApp has announced a major minor release of its data ONTAP storage operating system, promising data immortality and infinity.

Data ONTAP is NetApp's operating system for its FAS arrays and provides a unified file (NFS, pNFS and CIFS/SMB) and block (iSCSI, FCoE and Fibre Channel) storage array architecture. NetApp customers have been waiting for the company to integrate its acquired Spinnaker clustering technology into ONTAP and this release represents another stage of this multi-year effort.

NetApp says Data ONTAP 8.1.1 provides:-

- Immortal operations through zero downtime. System upgrades and maintenance don't disrupt array operations. - Infinite scalability with a single volume that can grow to 20PB. Er, sorry NetApp but 20PB is not infinite. I know; we're being picky. - "Set it and forget it" data protection. - Virtual array with Data ONTAP Edge; a version of ONTAP running as a virtual machine in an ESX server, which is cheaper than a FAS array and suitable for remote/branch offices needing up to 5TB of capacity - Secure multi-tenancy jointly with Cisco and VMware. - Combining SSD and HDD inside a volume or aggregate in the array as a Flash Pool which provides Virtual Storage Tiering (VST), or tiers without tears and, indeed, without tiers either as the SSDs are used as a read and write cache. - Clustering of up to six ONTAP arrays with each node potentially configured for different work, such as FC SAN access and filer activity.

The company says ONTAP 8.1.1 also delivers performance improvements and has better manageability and supportability. The Flash Pool technology enables SAS disks to be replaced by SATA ones with SSDs providing I/O acceleration. NetApp is providing this technology across its product range.

Our understanding is that NetApp will extend its VST technology to cover flash caches in servers so as to remove most network latency from data access by apps in servers.

With ONTAP 8.1.1 NetApp can offer an enterprise content repository with NFSv3 access to a container that can scale to 20PB and 2 billion files by using a cluster of five FAS6280 high-availability pair arrays; ten nodes in other words. Snapshot copies and SnapMirror replication are available as us NFS-mounted tape backup.

Data ONTAP EDGE includes Snapshot, SnapRestore, SnapVault, FlexVol, FlexClone and deduplication technologies. It provides iSCSI, CIFS and NFS protocol access but not Fibre Channel.

NetApp has taken over a now-discarded HP marketing theme, saying this new version of ONTAP makes IT agile. Its concept if having a single and multi-purpose storage infrastructure with one set of management and data protection tools is relatively unchanged although it is being amended by the inclusion of the E-Series for applications needing more data access speed.

EMC's chief blogger Chuck Hollis got his ONTAP 8.1.1 riposte in before the launch. He blogs; "after spending a few days getting to know what's in this release, if I were a NetApp customer I'd start thinking about Plan B," and contrasts NetApp's use of flash as a cache with EMC's se of storage tiering. He also contrasts the Isilon scale-out clustering with NetApp, but a high-end Isilon customer isn't likely to want to use a traditional 2-controller array.

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Storage company promises INFINITE IMMORTALITY

Research and Markets: Textbook of Assisted Reproductive Techniques: Clinical Perspectives

DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/whnkxx/textbook_of_assist) has announced the addition of the "Textbook of Assisted Reproductive Techniques: Clinical Perspectives" book to their offering.

Textbook of Assisted Reproductive Technologies has become a classic comprehsive reference for the whole team at the IVF clinic. The fourth edition comes more conveniently as a set of two separate volumes, one for laboratory aspects and the other for clinical applications.

The text has been extensively revised, with the addition of several important new contributions on clinical applications, including new chapters on lifestyle factors, tailored ovarian stimulation, frozen-thawed embryo transfer, viral disease, and religious perspectives. As before, methods, protocols, and techniques of choice are presented by eminent international experts.

Key Topics Covered:

Introduction to Third Edition. Robert Edwards: The path to IVF. IX Quality Management Systems

- Quality management in reproductive medicine. X Patient Investigation and the Use of Drugs

- Lifestyle, periconception, and fertility.

- Indications for IVF treatment: from diagnosis to prognosis.

- Initial investigation of the infertile couple.

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Research and Markets: Textbook of Assisted Reproductive Techniques: Clinical Perspectives

The math of malaria

Public release date: 20-Jun-2012 [ | E-mail | Share ]

Contact: Karthika Muthukumaraswamy karthika@siam.org 267-350-6383 Society for Industrial and Applied Mathematics

Philadelphia June 20, 2012Malaria affects over 200 million individuals every year and kills hundreds of thousands of people worldwide. The disease varies greatly from region to region in the species that cause it and in the carriers that spread it. It is easily transmitted across regions through travel and migration. This results in outbreaks of the disease even in regions that are essentially malaria-free, such as the United States. Malaria has been nearly eliminated in the U.S. since the 1950s, but the country continues to see roughly 1,500 cases a year, most of them from travelers. Hence, the movement or dispersal of populations becomes important in the study of the disease.

In a paper published this month in the SIAM Journal on Applied Mathematics, authors Daozhou Gao and Shigui Ruan propose a mathematical model to study malaria transmission.

"Malaria is a parasitic vector-borne disease caused by the plasmodium parasite, which is transmitted to people via the bites of infected female mosquitoes of the genus Anopheles," says Ruan. "It can be easily transmitted from one region to another due to extensive travel and migration."

The life cycle of plasmodium involves incubation periods in two hosts, the human and the mosquito. Therefore, mathematical modeling of the spread of malaria usually focuses on the feedback dynamics from mosquito to human and back. Early models were based on malaria parasites' population biology and evolution. But increased computing power in recent years has allowed models for the disease to become more detailed and complex.

Mathematical models that study transmission of malaria are based on the "reproduction number," which defines the most important aspects of transmission for any infectious disease. Specifically, it is calculated by determining the expected number of infected organisms that can trace their infection directly back to a single organism after one disease generation. The solution to controlling the disease is to arrive at a reproduction number at which the disease-free state can be established and maintained.

Previous studies used ordinary differential equations to model the transmission of malaria, in which human populations are classified as susceptible, exposed, infectious and recovered. Likewise, mosquito populations are divided into susceptible, exposed and infectious groups. The threshold below which the disease-free equilibrium can be maintained is determined by varying these parameters.

In order to analyze transmission rates of malaria between regions, multi-patch models are used, where each region is a "patch." These models study how the reproduction number is affected by dispersal or movement of exposed and infectious individuals from region to region.

The authors in this paper model the transmission dynamics of malaria between humans and mosquitoes within a patch, and then go on to examine how population dispersal between patches or regions affects the spread of malaria in a two-patch model.

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The math of malaria

Paper, Blog Heats Up GE Discussion

There's an interesting exchange on genetic engineering at the Food Politics blog, http://tinyurl.com/, featuring a review by industry critic Marion Nestle of an anti-GE paper, GMO Myths and Truths. I've skimmed the paper, which you can find at http://tinyurl.com/, and I confess to lacking the expertise to evaluate the claims. It would take more time than I have at the moment to dig into the claims, although I hope to do so in the future.

Nestle says the authors of the paper, who find nothing to like in genetic engineering, "have put a great deal of time and effort into reviewing the evidence for the claims. This is the best-researched and most comprehensive review I've seen of the criticisms of GM foods." She asks whether the pro camp can "produce something equally well researched, comprehensive, and compelling?" and concludes, "I doubt it but I'd like to see them try." She says there's enough evidence in the paper to justify labeling, at the very least.

It is, of course, the position you'd expect her to take, and several of the comments following her post challenge both her and the paper. One claims there are indeed well-researched, comprehensive and compelling pro papers. Others say the paper she cites cherry-picks evidence and relies on papers that have been debunked. An example cited in one of these critical comments asserts that it relies on a study of Bt found in human blood that used a test that couldn't detect blood at the levels the study's authors said they found.

My suspicion is most won't read these papers and will continue to think what they already think about the issue. An even worse fear is that reading the papers on both sides wouldn't convert anyone on either side. Still, I may give it a try at some point.

Follow me on Twitter: http://www.Twitter.comurbanize

Copyright 2012 DTN/The Progressive Farmer, A Telvent Brand. All rights reserved.

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Proposed Drug May Reverse Huntington's Disease Symptoms

Single treatment produces long-term improvement in animal models

Newswise With a single drug treatment, researchers at the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine can silence the mutated gene responsible for Huntingtons disease, slowing and partially reversing progression of the fatal neurodegenerative disorder in animal models.

The findings are published in the June 21, 2012 print issue of the journal Neuron.

Researchers suggest the drug therapy, tested in mouse and non-human primate models, could produce sustained motor and neurological benefits in human adults with moderate and severe forms of the disorder. Currently, there is no effective treatment.

Huntingtons disease afflicts approximately 30,000 Americans, whose symptoms include uncontrolled movements and progressive cognitive and psychiatric problems. The disease is caused by the mutation of a single gene, which results in the production and accumulation of toxic proteins throughout the brain.

Don W. Cleveland, PhD, professor and chair of the UC San Diego Department of Cellular and Molecular Medicine and head of the Laboratory of Cell Biology at the Ludwig Institute for Cancer Research, and colleagues infused mouse and primate models of Huntingtons disease with one-time injections of an identified DNA drug based on antisense oligonucleotides (ASOs). These ASOs selectively bind to and destroy the mutant genes molecular instructions for making the toxic huntingtin protein.

The singular treatment produced rapid results. Treated animals began moving better within one month and achieved normal motor function within two. More remarkably, the benefits persisted, lasting nine months, well after the drug had disappeared and production of the toxic proteins had resumed.

For diseases like Huntington's, where a mutant protein product is tolerated for decades prior to disease onset, these findings open up the provocative possibility that transient treatment can lead to a prolonged benefit to patients, said Cleveland. This finding raises the prospect of a huntingtin holiday, which may allow for clearance of disease-causing species that might take weeks or months to re-form. If so, then a single application of a drug to reduce expression of a target gene could reset the disease clock, providing a benefit long after huntingtin suppression has ended.

Beyond improving motor and cognitive function, researchers said the ASO treatment also blocked brain atrophy and increased lifespan in mouse models with a severe form of the disease. The therapy was equally effective whether one or both huntingtin genes were mutated, a positive indicator for human therapy.

Cleveland noted that the approach was particularly promising because antisense therapies have already been proven safe in clinical trials and are the focus of much drug development. Moreover, the findings may have broader implications, he said, for other age-dependent neurodegenerative diseases that develop from exposure to a mutant protein product and perhaps for nervous system cancers, such as glioblastomas.

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Proposed Drug May Reverse Huntington's Disease Symptoms

Civilization is not Ferguson’s best | Gene Expression

Last winter I took note of a major conflict between Pankaj Mishra and Niall Fergusonover a review by the former of the latters most recent book, Civilization: The West and the Rest. Ferguson accused Mishra of attempting to assassinate his character, and even suggested that he would take him to court over libel. This piqued my curiosity, so I added Fergusons latest work to my stack. I recently managed to get to it and finish it. Its a very quick and jaunty read. I enjoyed his The Ascent of Money and The Worlds Banker, but have avoided Fergusons forays into neoconservative intellectual polemic. Im obviously not a neoconservative myself, but normally disagreement with an individuals theses doesnt deter me from grappling with their ideas. Rather, the past decade of American history has been a wasteful experiment in neoconservative nation-building, and Id had enough of that. No need for more o that crap in flowery and more erudite paragraphs. But when it comes to economic history Niall Ferguson seems to be on more legitimate terrain, though his histories of the Rothschild House are much weightier tomes than something like The Ascent of Money. But to be frank The Ascent of Moneyis War and Peace next toCivilization.

So what of Mishras review? After reading Civilization I read it, and I quite understand where Fergusons anger was coming from. Panjak Mishra basically suggests that Ferguson is a racist, throwing sneering asides to Charles Murray so that the reader can be assured of the intent. In particular, an analogy is clearly made between Ferguson and Lothrop Stoddard, author of works such as The rising tide of color against white world-supremacy. Stoddards opinion, the rising tide of color, bad, white supremacy, good. A normal Westerner in this day and age would find the comparison offensive, but in Fergusons case its particularly galling, because he has a mixed-race son with Ayaan Hirsi Ali.

I suspect that Fergusons first instinct was to track Mishra down and beat the living shit out of him. I know that would be my own instinct in his position. They fuck you up, your kids. To me that explains his outrageous attempt to silence Mishras obnoxious imputations with the threat of the law. Britain has ridiculously pro-plaintiff courts in regards to libel, but Niall Ferguson makes a great show of being American, and in the United States it is totally acceptable to make tenuous accusations against the motives of public figures. Rather than fight with the law Ferguson should probably just have accused Mishra of being a Communist with sympathies toward genocidal Leftist regimes like that of Pol Pot. I know, juvenille, but the Leftist intellectual usage of the term racism is of the same nature as the old red-baiting of the Cold War. If you dont have coherent arguments, simply insult and accuse, with sure knowledge that your ideological allies wont inspect your accusations with any degree of skepticism.

Whats a shame though is that many of Mishras substantive critiques ofCivilizationare spot on. Niall Fergusons story of the rise of the West involves six killer apps. They are:political and economic competition, the scientific revolution, the rule of law, modern medicine, education and the work ethic. Where this argument is persuasive, its not original (e.g., the scientific revolution). Where it is novel, it is not worked out in much detail (e.g., medicine). The book is simply far too ambitious in scope in relation to the thesis being presented. Rather than an argument,Civilizationconsists mostly of bald assertions occasionally sprinkled in with some insight which one wishes would be followed up in more detail. For example, as Mishra notes there is much warmed-over Webberianism in Fergusons narrative, but he does present the idea that Protestantism was not useful for the work ethic in a direct manner, but that it increased in human capital and therefore potential productivity through the spread of literacy due to the shift toward personal reading of the Bible. Yes, there are notes, but I wish Ferguson would have pushed more into this area and fleshed out his thoughts, because he reports that this effect holds true in non-Western societies too (i.e., Protestant areas have higher literacy, all things areas, vis-a-vis Roman Catholic areas).

But I assume that it is in the area of colonialism that Niall Ferguson might rankle many. His enthusiasm for empire is well attested, so its not surprising that he doesnt give a totally negative account of the colonial adventure, in both intent and outcome. A world of post-colonial theory this is a big no-no, and clearly was the reason for why Pankaj Mishra accused Ferguson of being a racialist of yore. Long-time readers know that Im not a fan of post-colonial theory, which makes a fetish of the power of the white race, and totally ignores the agency of colored peoples, for good or ill. In particular I found it interesting howCivilizationoutlined the different natures of Western colonialism. Not only does post-colonial theory tend to reduce the colored experience into one of amorphous subalterns, but there also does not seem to be a deep exploration of the reality that French colonialism was qualitatively different from British colonialism which was qualitatively different from German colonialism. This section of the narrative is worth expanding, but in the interests of covering all his killer apps Ferguson simply moves on hastily.

Finally, there are aspects of the book which are amateurish and tendentious in the extreme. As Mishra notes Ferguson dismisses Kenneth Pommeranzs argument in The Great Divergence with barely a word. I understand thatCivilizationis not a scholarly work, but I also found it frustrating that the reader might not be aware that one of Pommeranzs observations is that too often the most dynamic areas of Europe (e.g., England) are compared to the whole of China, with the appropriate comparison is apples to apples (e.g., England vs. the zone around Shanghai). If you read Fergusons narrative this isnt clear at all, and in fact he regularly does compare England itself to all of China. The section on religion and Christianity was also very hackneyed. Much of the portion on China and Christianity is taken directly from Jesus in Beijing, a work of a journalist, not a scholar. Many of the statistics and projects are basically pulled out of thin-air, though to be fair that is a problem with religion & China more generally thanks to government obstruction. Ferguson regales the reader with the fact that Chinese social scientists are convinced that Christianity is the reason for Western success, and that Jiang Zemin wanted to make Christianity Chinas official religion. The former is unsourced, while Zemin is also rumored to be a private practitioner of Buddhism. In other words, question the veracity of these claims. Not only that, there is a strange juxtapositionbetween the section on the implicit necessity of Christianity for Chinas modernization, and Japans wholesale adoption of Western ways. Ferguson neglects to mention that there was one thing which Japan did not adopt wholesale: Christianity. And last I checked Japan was a modern society, which somehow managed to develop (granted, Christians have been a catalytic force in Japanese society over the past century).

OverallCivilizationgets 2.5 stars from me. If you know a lot of history its a quick read, and you can probably separate the wheat from the chaff easily. Im not quite sure why youd want to read it, as it doesnt get much further than the op-eds which Ferguson has been penning (and the conceit of killer apps gets really annoying in my opinion). If you arent well versed in history you should probably not read this book, because youre too ignorant to figure out where Ferguson is bullshitting, and where hes being a serious scholar (you can check the notes, but he switches between the type of books published by university presses to superficial mass market nonfiction).

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Gene sequencing project identifies potential drug targets in common childhood brain tumor

Public release date: 20-Jun-2012 [ | E-mail | Share ]

Contact: Summer Freeman summer.freeman@stjude.org 901-595-3061 St. Jude Children's Research Hospital

Researchers studying the genetic roots of the most common malignant childhood brain tumor have discovered missteps in three of the four subtypes of the cancer that involve genes already targeted for drug development.

The most significant gene alterations are linked to subtypes of medulloblastoma that currently have the best and worst prognosis. They were among 41 genes associated for the first time to medulloblastoma by the St. Jude Children's Research Hospital Washington University Pediatric Cancer Genome Project.

"This study provides new direction for understanding what drives these tumors and uncovers totally unexpected new drug targets. There are drugs already in development against these targets aimed at treating adult cancers and other diseases," said Richard Gilbertson, M.D., Ph.D., St. Jude Comprehensive Cancer Center director. Gilbertson and Jinghui Zhang, Ph.D., an associate member of the St. Jude Department of Computational Biology, are the study's corresponding authors. The work appears in the June 20 advance online issue of the scientific journal Nature.

The results mark progress toward more targeted therapies against medulloblastoma and other cancers. While better use of existing drugs and improved supportive care have helped push long-term survival rates for childhood cancer to about 80 percent, drug development efforts have largely stalled for more than two decades, particularly against pediatric brain tumors.

"This study is a great example of the way whole-genome sequencing of cancer patients allows us to dig deep into the biology of certain tumors and catch a glimpse of their Achilles heel," said co-author Richard K. Wilson, Ph.D., director of The Genome Institute at Washington University School of Medicine in St. Louis. "These results help us better understand the disease and, as a result, we will be able to more effectively diagnose and treat these kids."

This study involved sequencing the complete normal and cancer genomes of 37 young patients with medulloblastoma, making it the largest such effort to date involving the cancer. Researchers then checked tumors from an additional 56 patients for the same alterations. The genome is the complete set of instructions needed for human life. It is carried in the DNA found in nearly every cell.

The findings are part of the Pediatric Cancer Genome Project, which launched in 2010 as a three-year effort to decipher the complete normal and tumor genomes of 600 young cancer patients with some of the most challenging tumors. The endeavor has already yielded important clues into the origin, spread and treatment response in childhood cancers of the blood, brain, eye and nervous system.

Medulloblastoma is diagnosed in about 400 U.S. children and adolescents annually. Their outcome varies widely based on the subtype they have. While nearly all patients with the wingless (WNT) subtype survive, just 60 percent of those with subtype 3 medulloblastoma are alive three years after diagnosis. WNT medulloblastoma is named for the pathway disrupted in the tumor subtype.

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Gene sequencing project identifies potential drug targets in common childhood brain tumor

High school chemistry teachers re-enact Benjamin Burtt's famous Water Lecture

Along with teaching chemistry, Burtt also was a passionate bird watcher and wrote a weekly column for The Post-Standard for more than 50 years.

Benjamin P. Burtt Sr., who taught chemistry at Syracuse University for nearly 50 years, had such an influence on his students that they decided to honor his memory in a special way by recreating his famous Water Lecture.

The lecture, which he gave to freshmen every year shortly before finals, was a joke presentation that he did seriously, including demonstrations that go wrong and an explosion. Students say it was funny and a great stress reliever.

Burtt, who died in February at age 91, influenced many students to love chemistry so much that they went on to become chemistry teachers.

One of his former students, Jamie Cucinotta, a Fayetteville-Manlius chemistry teacher since 1997, has taken a lead role in coordinating the special event on Thursday.

She, along with East Syracuse Minoa chemistry teacher Sally Mitchell and SU chemistry professor Michael Sponsler, will re-enact the lesson at 7 p.m. at Syracuse Universitys Stolkin Auditorium.

The event, sponsored by the Syracuse Section of the American Chemical Society, is open to the public. It also will include recognition of U.S. and local National Chemistry Olympiad exam takers and others being honored for achievements in chemistry.

Cucinotta said Burtts legacy lives on through the scores of chemistry students he taught and influenced.

Cucinotta, who was Mitchells mentor and master teacher, said she believes Burtts influence inspired many chemistry teachers. At the event, which has been named as the Ben P. Burtt Lecture Series, students and teachers who have made a difference in chemistry also will be honored.

Cucinotta said Burtt was was a very good, intense teacher, she said. and he tested on what he taught.

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High school chemistry teachers re-enact Benjamin Burtt's famous Water Lecture

Intellectual Property Encourages Collaboration, R&D in Developing Economies

WASHINGTON--(BUSINESS WIRE)--

The Biotechnology Industry Organization (BIO) unveiled a report on the role of intellectual property rights in encouraging upstream research and development as well as downstream commercialization of biotechnology at the 2012 BIO International Convention.

This report is further proof of the positive impact of intellectual property rights in both established and emerging economies, and will be a useful tool as we work with the many countries seeking to grow the biotechnology industry, stated Joseph Damond, BIO Senior Vice President of International Affairs. We felt it was important to provide empirical evidence and case studies for a more informed discussion on the role of intellectual property in global economic development and in commercializing innovative products for patients and other consumers.

The report outlines how intellectual property rights and technology transfer mechanisms encourage collaboration and lead to the research and development of new biotechnologies, particularly in emerging and developing economies.

The report, titled Taking Stock: How Global Biotechnology Benefits from Intellectual Property Rights, found that:

There is a growing body of evidence suggesting a positive link between economic development and growth, technology transfer, increased rates of innovation and the strengthening of intellectual property rights. This is particularly promising in certain knowledge-intensive sectors, such as biopharmaceuticals, said Meir Pugatch, Managing Director and Founder of the Pugatch Consilium.

The report was authored by Meir Perez Pugatch, David Torstensson and Rachel Chu of the Pugatch Consilium and is available at http://www.bio.org/sites/default/files/Pugatch%20Consilium%20-%20Taking%20Stock%20Final%20Report%20%282%29.pdf.

About BIO

BIO represents more than 1,100 biotechnology companies, academic institutions, state biotechnology centers and related organizations across the United States and in more than 30 other nations. BIO members are involved in the research and development of innovative healthcare, agricultural, industrial and environmental biotechnology products. BIO also produces the BIO International Convention, the worlds largest gathering of the biotechnology industry, along with industry-leading investor and partnering meetings held around the world. BIO produces BIOtechNOW, an online portal and monthly newsletter chronicling innovations transforming our world. Subscribe to BIOtechNOW.

Upcoming BIO Events

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Intellectual Property Encourages Collaboration, R&D in Developing Economies

Americans and Biotechnology Executives Remain Optimistic About Future of Biotechnology Despite Serious Industry …

BOSTON--(BUSINESS WIRE)--

The Biotechnology Industry Organization (BIO) today unveiled several new opinion surveys at the 2012 BIO International Convention, taking place this week in Boston. The surveys - conducted by the bipartisan pairing of Public Opinion Strategies and Hart Research Associates - found:

"These survey results are clear: The American people want policymakers to support cutting-edge research that will enable biotechnology to fulfill its potential to heal, fuel and feed the world, said Jim Greenwood, President and CEO of BIO. We are at a critical crossroads. We need policies in place that support investment in biotech innovation and a more streamlined regulatory process that properly protects patient safety and speeds the delivery of breakthrough medicines and cures to sick patients or we risk losing Americas leadership in biotech innovation.

The research included a survey of national voter attitudes, a survey of biotechnology executives and a third survey examining the attitudes of those attending the 2012 BIO International Convention.

Biotechnology Executives Concerned About Regulatory Burdens, Less Optimistic

The survey of executives at BIO members companies found these industry leaders believe government regulation has had a negative impact on the biotech industry and this is largely unchanged compared to a survey conducted on behalf of BIO five years ago (58 percent today vs. 56 percent in 2007). They are less optimistic today than they were in 2007 (63 percent compared to 79 percent) that, in the future, the biotechnology industry will continue to develop new therapeutics and products to help address global needs in healthcare, agriculture, energy and the environment.

When compared to BIOs 2007 survey, todays industry executives reported the following:

Other key findings in the research include:

Methodology

The national surveys of N=169 BIO member company executives and of N=800 registered voters were conducted May 14-24 and May 20-23, 2012, respectively, by Public Opinion Strategies and Peter D. Hart Research Associates on behalf of the Biotechnology Industry Organization.

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Americans and Biotechnology Executives Remain Optimistic About Future of Biotechnology Despite Serious Industry ...

Biotechnology Institute Leads Effort to Bring Life Science Education, Workforce Training and Entrepreneurship to the …

BOSTON--(BUSINESS WIRE)--

The Biotechnology Institute announces today the formation of the nationally coordinated effort of state bioscience organizations. This effort the Coalition of State Bioscience Institutes (CSBI) - ensures Americas leadership in bioscience innovation by delivering industry-led life science education, workforce development and entrepreneurship programs across the county. The Biotech Institute is a founding member of CSBI and serves as its administrative organization. The formation of CSBI was announced at the 2012 BIO International Convention, the industrys global event for biotechnology that is hosted by the Biotechnology Industry Organization (BIO).

By convening the countrys state bioscience programs through this Coalition, we are able to serve as the conduit betweenlearning institutions and life science companies, said Janelle Curtis, Biotechnology Institute VP for Programs. As the countrys national organization dedicated to bioscience education, the Institute looks forward to working with this group toward our common goal to support innovation in the life sciences.

CSBI is leveraging resources across the United States to speak with a united voice for the biotech industry on life science education, workforce development and entrepreneurship, said CSBI acting co-chair Lance Hartford, executive director, MassBioEd. We focus on programs that the life science industry is uniquely positioned to deliver and can be replicated across many states and scaled-up nationally.

Currently, CSBI is identifying leading state programs for national consideration. These programs include teacher-training initiatives such as iBIO Institutes TalentSparks!; workforce competitiveness programs including Oregon Bioscience Associations BioPro and BIOCOM Institutes BioCollaborative; and BayBio Institutes Expert Network resource for entrepreneurs. CSBI is also designing a web-based clearinghouse of all current state-level programs focused on life science education, workforce training and entrepreneurship.

Working together since December 2011, CSBI serves as an umbrella for standard practice sharing, joint fundraising and national initiatives for life science (STEM) education (student education, career exploration and teacher professional development); workforce development (workforce training, incumbent worker professional development, dislocated worker training); and entrepreneurship. CSBI provides the opportunity for state bioscience organizations to share knowledge with the goal of improving bioscience education and innovation, while maximizing industry support. With its focus in these areas, the CSBI complements the life science policy work of the Council of State Bioscience Associations (CSBA), formed by BIO in 2002.

CSBI founding organizations include BayBio Institute, BIOCOM Institute, the Biotechnology Institute, iBIO Institute, KansasBio, MassBioEd, MdBio Foundation and the Oregon Bioscience Association. Forty-one state bioscience organizations are CSBI members with nine additional groups expected to join. The Coalition is co-chaired by BayBio Institute executive director Lori Lindburg and MassBioEd executive director Lance Hartford. The Biotechnology Institute serves as CSBIs administrative organization. By partnering, CSBI members bring unprecedented access to programs, facilitate national communication, and connect an extensive network of industry professionals. CSBI is supported with funding provided by Human Genome Sciences.

ABOUT THE BIOTECHNOLOGY INSTITUTE

The Biotechnology Institute is an independent, national nonprofit organization dedicated to education about the present and future impact of biotechnology. Its mission is to engage, excite and educate the public, particularly students and teachers, about biotechnology and its immense potential for solving human health, food and environmental problems. For more information, visit http://www.biotechinstitute.org.

ABOUT THE BIO INTERNATIONAL CONVENTION

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How Protein Clumps Are Pulled Apart

Editor's Choice Main Category: Biology / Biochemistry Article Date: 20 Jun 2012 - 11:00 PDT

Current ratings for: 'How Protein Clumps Are Pulled Apart'

In humans, amyloid fibers form biological nanostructures that house pigments and other molecules, and may also play an important role in long-term memory. These fibers are one of the most stable protein-based structures in nature, so when they are harmful in diseases, such as Parkinson's, they are extremely difficult for cells to break down.

As a result, Martin Duennwald and AnaLisa Echeverria, at the Boston Biomedical Research Institute, and James Shorter, assistant professor of Biochemistry and Biophysics at the University of Pennsylvania, set out to find ways to promote beneficial amyloid fiber assembly or to reverse its pathogenic assembly, at will. The study is published in PLoS Biology.

Yeast have a protein called Hsp104 that can quickly disassemble amyloid fibers, and this activity is significantly enhances by a group of small heat shock proteins. However, humans and other animals do not have the Hsp104 protein, thus raising the question of whether human cells are also capable of disassembling amyloid fibers?

In this study, the researchers found that when Hsp104 is absent, the yeast small heat shock proteins work together with other proteins to disassemble amyloid fibers. The proteins slowly remove each subunit one by one from the tips of the fibers. The team were surprised by this activity as these proteins are best known for their role in preventing protein clumping.

Shorter explained:

According to the researchers, the proteins of the amyloid-disaggregating machinery in yeast are also present in humans. Therefore, human small heat shock proteins are able to work together with other proteins to disassemble amyloid fibers, even without Hsp104.

They state that these findings could lead to the development of new therapies for different neurodegenerative disorders.

Their aim is to activate the machinery in humans to pull apart disease-causing amyloid fibers where and when needed by increasing the expression of heat shock proteins.

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How Protein Clumps Are Pulled Apart