Putting health care on the right track

The Washington Posts Robert Samuelson castigated President Obama in a recent column for a lack of judgment in getting his landmark health-reform law passed. I profoundly disagree.

Obamacare is helping our nation achieve health care that is excellent, accessible to all and affordable. In the 17 months that I led the Centers for Medicare and Medicaid Services, or CMS, I saw how this law is helping tens of millions of families and is finally putting our health care system on the right track.

Samuelson is right to be concerned about health care costs. Weve been on an unsustainable path for decades. But while he offers no remedy beyond the broken status quo, the presidents reform helps us make health care sustainable the right way: by improving it, not cutting it.

The law does this by targeting the underlying drivers of high health care costs: It supports and rewards caregivers for preventing complications of care, such as health care associated infections, which save both lives and money. The CMS, for example, has set ambitious goals to reduce complications that, if met, would save 60,000 lives and $35 billion in just three years. The law also emphasizes preventive care and cracks down hard on waste and fraud. Last year the government recaptured a record $4 billion. It fosters transparency, so everyone can tell the best performers from the rest. Rather than paying for volume, the law helps us pay for value.

I have seen how improving care can reduce costs dramatically.

The Henry Ford Health System in Detroit has documented savings of $10 million per year from its efforts to improve patient safety. The Nuka system of team-based primary care in Anchorage has reduced hospital days more than 50 percent.

Denver Health, using modern, lean production approaches to decreasing waste in health care processes, has reduced costs by more than $150 million and achieved the lowest mortality rates among 115 comparable academic medical centers. The Affordable Care Act will help make these successful examples the norm.

The law also stops insurance companies from taking advantage of consumers. It prevents insurers from putting lifetime caps on coverage.

Before Obamacare, 105 million people had one of these caps buried in their insurance contracts every year, 20,000 unlucky Americans got letters from their insurers saying their coverage was running out. It didnt matter if they were in their second round of chemotherapy or waiting for surgery; the insurance companies simply said no. Because Obamacare lifted those caps, families have better care and peace of mind.

Obamacare has allowed millions of young people to stay on their parents plans until age 26, and it requires insurance companies to cover the preventive care needed to stay healthy. It gives consumers the right to appeal an insurers decision and stops insurers from denying coverage to children with pre-existing conditions.

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Putting health care on the right track

Pathway Genomics Partners with DASA, the Largest Private Medical Diagnostics Company in Brazil

SAN DIEGO--(BUSINESS WIRE)--

Pathway Genomics Corporation, a San Diego-based genetic testing laboratory, has partnered with Diagnsticos da Amrica (DASA), the largest private medical diagnostics company in Latin America and the fourth largest provider of diagnostic services in the world. Based in Brazil, DASAs clinical analysis division collects samples from more than 500 patient service centers and has 11 central laboratories. DASAs brands include Alta Excelncia Diagnstica, Delboni Auriemo, Lavoisier, CDPI, Srgio Franco, Pasteur, Exame and others. Through this partnership, physicians have access to Pathways valuable genetic testing services, bringing additional personalized care to more than 180 million people in Brazil.

Pathways vision is to responsibly reveal personalized and actionable genetic information in order to globally educate, inform and improve health and well-being, said Dr. Michael Nova, Pathways chief medical officer. Our alignment with DASA is a major part of this vision, and we are excited to help bring this scientifically-advanced technology to the people of Brazil.

Specifically, through DASA, physicians in Brazil now have access to multiple genetic tests, including:

The partnership between DASA and Pathway represents a milestone in Brazilian medicine, ensuring access to predictive genetic tests through an advanced and innovative technology, said Dr. Octvio Fernandes, DASAs chief operating officer. DASA is a reference in Brazil due to our excellence, innovation and quality in medical diagnostic services. With 50 years of expertise, the company has one of the largest medical teams in Latin America, composed of nearly 2,000 world-renowned doctors, and offering more than 3,000 types of laboratory tests and imaging diagnostics provided by more than 18,000 professionals.

Pathways laboratory is accredited by the College of American Pathologists (CAP) and accredited in accordance with the U.S. Health and Human Services Clinical Laboratory Improvement Amendments (CLIA) of 1988. Pathway is also a member of the American Clinical Laboratory Association (ACLA). The company consists of more than 40 scientific and medical professionals, including medical doctors, molecular geneticists, and genetic counselors, as well as an expert scientific advisory board.

About Pathway Genomics Corporation

Pathway Genomics owns and operates an on-site genetic testing laboratory that is accredited by the College of American Pathologists (CAP), accredited in accordance with the U.S. Health and Human Services Clinical Laboratory Improvement Amendments (CLIA) of 1988, and licensed by the state of California. Using only a saliva sample, the company incorporates customized and scientifically validated technologies to generate personalized reports, which address a variety of medical issues, including an individuals carrier status for recessive genetic conditions, food metabolism and exercise response, prescription drug response, and propensity to develop certain diseases such as heart disease, type 2 diabetes and cancer. For more information about Pathway Genomics, visit http://www.pathway.com.

About DASA

DASA is the largest private medical diagnostics company in Latin America offering a portfolio of over 3,000 clinical analysis and imaging tests. In the clinical analysis segment, samples are collected in more than 500 patient service centers and analyzed in 11 central laboratories. In the diagnostic imaging segment, the images are submitted to physicians for analysis and reporting according to their medical specialty. For more information about DASA, visit http://www.dasa.com.br.

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Pathway Genomics Partners with DASA, the Largest Private Medical Diagnostics Company in Brazil

Research and Markets: Translational Regenerative Medicine – Oncology, CNS and Cardiovascular-Rich Pipeline Features …

DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/skdhnn/translational_rege) has announced the addition of the "Translational Regenerative Medicine - Oncology, CNS and Cardiovascular-Rich Pipeline Features Innovative Stem Cell and Gene Therapy Applications" report to their offering.

More Guidelines Needed to Grow Regenerative Medicine Market, Report Finds

Standardized research guidelines are needed to control and encourage the development of gene therapy and stem cell treatments, according to a new report by healthcare experts GBI Research.

The new report* shows how regenerative medicine is seen as an area with high future potential, as countries need ways to cope with the burden of an aging population.

The stem cell market alone is predicted to grow to around $5.1 billion by 2014, while gene therapy has also shown promise despite poor understanding of some areas of regenerative medicine and a lack of major approvals (the only approvals to date being made in Asia).

Up until now, securing research within clinics has been difficult, with a high number of failures and discontinuations throughout all phases of clinical study. Stem cell therapy uses bone marrow transplants as an established treatment method, but the development of the therapy into further applications and has not yet become common practice.

Similarly, tissue engineering has been successful in the areas of skin and bone grafts, but translation into more complex therapies has been an issue for researchers. Although scientific possibilities are ever-increasing, the true potential of regenerative medicine has yet to be demonstrated fully.

A desire to discover new and innovative technologies has encouraged governments in the UK and Singapore to focus directly on regenerative medicine as a future potential economy booster.

Companies Mentioned:

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Research and Markets: Translational Regenerative Medicine - Oncology, CNS and Cardiovascular-Rich Pipeline Features ...

Freedom of press on wane, say journos

Winnie Chong

Monday, June 25, 2012

Press freedom in Hong Kong has worsened since Donald Tsang Yam-kuen became chief executive in 2005.

That is the belief of four in every five journalists, according to a survey by the Hong Kong Journalists Association.

It found that 86.9percent of the 663 reporters, photographers, editors and management polled in April believe the situation has worsened.

That is 28.5 percentage points more than those who thought the same at the last survey in 2007.

Nearly two in five (35.9 percent) admit they or their supervisors practice self-censorship - six percentage points more than in 2007.

Nearly everyone - 92.7percent - said media coverage is being hindered because government officials exert tighter control over the flow of information.

About seven in 10 (71 percent) said self-censorship exists in the industry, as management plays down negative news of big corporations that wield strong influence over advertising (40.3 percent), information unfavorable to the central government (37percent), and news reports which tend to favor individual chief executive candidates (33.6 percent).

More than 67percent of respondents believe the central government liaison office is exerting political interference over press freedom.

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Freedom of press on wane, say journos

Hongkongers' Press Freedom Threatened By China's Creeping Influence

An overwhelming majority of journalists say press freedom has deteriorated significantly under Chief Executive Donald Tsang’s administration, according to a recent survey. The Hong Kong Journalists Association’s latest survey on self-censorship found that 86.9% of journalists have felt a tighter grip of information by the government, a 28.5% increase from a similar survey in January 2007.

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Hongkongers' Press Freedom Threatened By China's Creeping Influence

Drought conditions force closure of 4 Ind. beaches

by Associated Press

WHAS11.com

Posted on June 24, 2012 at 8:45 PM

Updated yesterday at 9:01 PM

BIRDSEYE, Ind. (AP) -- Four Indiana beaches have been closed this summer by DNA officials due to drought conditions.

The state Department of Natural Resources closed the beach at Patoka Lake Reservoir in southern Indiana Friday because of low water levels, the fourth beach closure by the agency caused by the drought.

The state earlier closed beaches at Salamonie Lake, 30 miles southwest of Fort Wayne, Mississinwea Lake near Peru, and Raccoon Lake near Rockville. Agency spokesman Phil Bloom says all four lakes are flood control reservoirs controlled by the Army Corps of Engineers.

The U.S. Drought Monitor map released Thursday at least 80 percent of Indiana is suffering at least a moderate drought and the state's southwestern corner has extreme drought conditions.

The dry conditions have led more than half of Indiana's 92 counties to implement open burning bans.

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Drought conditions force closure of 4 Ind. beaches

Kailua Beaches Get Free Rescue Tubes

Kailua (HawaiiNewsNow) - The Windward Oahu Sunrise Rotarians raised money to buy rescue tube set-ups hoping to reduce drowning deaths by providing life-saving equipment at beaches.

Kane McEwen demonstrated how to use the rescue tube by simply removing two velcro straps and pulling the floating device off of a buried stake.

McEweb and other Rotary club members made their way along the Kailua shoreline installing the safety devices at locations they thought might be helpful to anyone who may need help. "Let's hope it never has to be used but if it does need to be, it's here," said McEwen.

They are hoping to follow the lead of the Rotary club on Kauai. The group there has installed over 200 of the devices. "They have five recorded full rescues with those, so much so that one man and his son were found at about a mile and a half floating with that out, outside when they finally got to him with the jet-skis and the lifeguards," McEwen said.

McEwen also said he hopes the community will take pride in the safety units. "Knowing that it's their family and friends who could possibly need it someday too," he continued.

The group did not seek approval from city or state officials for the implementation of the floatation units but say they have gotten the word out and have received positive feedback. "We had the fire department, life guards, some of our local congressmen have been in our meetings and heard about what we are doing and it sounds like we have the support of the whole community," he told Hawaii News Now.

The group says other counties are now embracing the rescue tube idea.

State officials said they would head out to Kailua on Monday to inspect the devices.

Copyright 2012 Hawaii News Now. All rights reserved.

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Kailua Beaches Get Free Rescue Tubes

Volunteer groups tidy beaches

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Volunteer groups tidy beaches

Brain Physiology and the Chris Benoit Tragedy

Before I dive right into Benoit, it is important to have an understanding of what a concussion is and how it affects people. Concussions are the most common form of brain injury, yet they are still widely misunderstood.

Concussions occur when the brain strikes the interior surface of the skull. When a persons head is rapidly moved, the brain inside moves as well. The brain is not stationary, so rapid movements cause the brain to sway inside. As the brain impacts the skull, bruises are formed, and the bruising is what concussions are, on a basic level. Once a bruise (concussion) happens on the brain, it is there forever. The brain is made up of nerve cells, and oddly enough, nerve cells do not go through cell division. Cell division is how all our other cells get repaired when they are damaged.

Now, since these cells do not get repaired, it is critical that a person not suffer more than one concussion in the same area of the brain. By injuring the same spot over and over, you begin to develop severe deficits that will affect how you live your life.

This was the problem with Chris Benoit. It is my theory that due to Benoits style of wrestling, and signature moves he performed, it was likely that he suffered multiple concussions in the same area of the brain. June 24, 2007. Wow, has it really been that long? That night, the ECW Championship was to be won by the Rabid Wolverine, Chris Benoit. At the time, we were told that Benoit would not be able to make the event. We were left a bit confused and also a bit skeptical. This announcement could easily have been a swerve, or it could have been an appetizer to a brand new storyline.

The following night on Raw, we learned that Chris and his family had died. There were more questions than answers, and we were left with a hole in our wrestling hearts. Another great talent in the business died far too early. It was not until later in the month did we find out that something had happened to Chris that made him kill his family and then himself. The mainstream media jumped all over this tragic tale, stating that steroids were what made Benoit snap. Nobody seemed to consider any other options.

At the time, I was just beginning my paramedic career, and I knew very little about brain injuries and the impact they have on the rest of your life. Now, after many more years of medical experience, I feel confident that the Benoit tragedy was because the brain in Chris head had suffered so much impact over his incredible career that he no longer was able to differentiate right from wrong, reality from fantasy.

We all know that one of Chris trademark moves was the diving head butt. Even though he would not make head-to-head contact, he would still make impact with the shoulder and chest area of his opponent. Over time, his body realized that his head was making constant impacts, and it began tosend more calcium to skull to protect it. Calcium is what our bones are made up of. The skull, which is the only bone in the body to protect the brain, built up calcium on the front of his skull. This calcium deposit, over time, provided extra strength to the bone itself so it would not develop a stress fracture.

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Brain Physiology and the Chris Benoit Tragedy

Michelle Obama's War on Cranberries [Nutrition]

The First Lady is not making many friends in the cranberry industry.

Thanks to Michelle Obama's "Let's Move" initiative, the Department of Agriculture will soon create stricter guidelines for what can be sold in school vending machines and cafeterias. This could signal the end of young people drinking cranberry juice cocktail and that's bad news for the cranberry industry.

Yes, cranberry juice cocktail. It's made with real fruit, sure, but it's also full of sugar. Cranberries are incredibly bitter and tart on their own, which is why they're usually mixed with an awful lot of sweetener. Despite the nutrition benefits, these sugary blends may not mesh with new guidelines.

Wisconsin cranberry grower Linda Prehn breaks it down for you.

Cranberries can be sweetened with anything. But you can't eat 'em raw. They're tough to eat straight up.

"Anything," you say? Prehn recommends apple juice. OK, so school vending machines might ditch the good stuff, but surely there's some sort of healthy cranberry juice alternative. (Sorry, Ocean Spray.)

After all, cranberries do a lot of good they contain antioxidants (more than most other fruits) and can prevent urinary tract infections by promoting bladder and kidney health. The cranberry industry has sent appeals to Michelle Obama and to the Department of Agriculture, noting that the benefits of cranberries outweigh the risks of a little added sugar intake.

But the debate rages on. Margo Wootan, director of nutrition policy for the Center for Science in the Public Interest, believes that cranberry juice cocktails' sugar content are of the utmost concern.

There's some evidence to show that cranberry juice can prevent urinary tract infections, but that doesn't mean everyone should be drinking cranberry juice every day. Only 3 percent of kids a year have urinary tract infections, compared to one-third who are overweight. Urinary tract infection is not a booming epidemic. Obesity is.

Sure, parents could still buy cranberry juice for their kids outside of school, but the cranberry industry worries what kind of message these school policies send after all, cranberry juice is being lumped together with soda and other "things we know are pretty bad for you." That could create an association between Coca-Cola and cranberry, which might dissuade adults from keeping their fridge stocked with Ocean Spray.

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Michelle Obama's War on Cranberries [Nutrition]

Cranberry industry wary of upcoming nutrition standards

WASHINGTON (USA TODAY) The federal government is expected to propose new nutrition standards soon that could leave a bitter taste in the mouths of cranberry growers from Massachusetts to Wisconsin.

To address childhood obesity in America, an effort spurred by first lady Michelle Obama's "Let's Move" initiative, the Department of Agriculture is finalizing guidelines for what can be sold in school vending machines, stores and a la carte cafeteria lines. Sugar is widely viewed as a target, and sweetened beverages like cranberry juice cocktail could be deemed unhealthy.

That would be unfortunate and unfair, cranberry industry officials say, because the tart, deep red fruit is loaded with nutrients and health benefits. But for consumers to avail themselves of those benefits, cranberries must be sweetened.

"Cranberries can be sweetened with anything," said Linda Prehn, a cranberry grower in Tomah, Wis., citing apple juice as an example. "But you can't eat 'em raw. They're tough to eat straight up."

Prehn, chairman of United Cranberry Growers Cooperative, a collective of 85 growers in Massachusetts, Oregon and Wisconsin in the U.S. and New Brunswick and Quebec in Canada, was among cranberry industry honchos attending the recent inaugural meeting of the Congressional Cranberry Caucus on Capitol Hill.

Prehn and others are hoping the bipartisan caucus led by Reps. Reid Ribble, R-Wis., and Bill Keating, D-Mass., and Sens. John Kerry, D-Mass., and Scott Brown, R-Mass., can help persuade agriculture officials to make an exception for cranberry products in its nutrition standards for added-sugar products.

"Given the beneficial and scientifically proven health properties of cranberries, we believe there is a need to establish clear standards that recognize cranberries as a part of a healthy diet," the lawmakers wrote in a letter to Agriculture Secretary Tom Vilsack. "We ask that you consider including a variety of cranberry juice and dried cranberry products in USDA's food nutrition program so that children, seniors and adults served by these programs are not denied benefits unique to cranberries."

The lawmakers sent a similar letter to the first lady, pointing out cranberries "contribute to whole body health, particularly urinary tract health and the potential to fight cancer and other diseases."

At stake is exclusion from an estimated $2.3 billion school vending machine business and an image that could have a negative impact on the marketing of cranberry products worldwide, particularly cranberry juice cocktail, industry officials say.

"If we're put into a category that says these types of products are unhealthy, we think it would be inaccurate and unfair," said Tom Lochner, executive director of the Wisconsin State Cranberry Growers Association. "Lumping us in with other beverages that don't have the health benefits associated with them that cranberries do is definitely going to affect our ability to sell cranberry products."

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Cranberry industry wary of upcoming nutrition standards

KOTD – Rap Battle – DNA vs Eurgh – Video

24-06-2012 19:10 **PLEASE? Click 'LIKE'? & Add To Favourites If You Enjoyed This Video!!! Make sure to check out the KOTD website at - World Domination 3 tickets on sale soon - Since the dawn of the new era of battling, few rappers have shown as much passion and work-ethic as DNA. Getting his start with Grind Time as one of the youngest battlers in the league, he quickly proved that age was not a factor as he moved up in the ranks. After facing opponents such as Rone, Loe Pesci and P-Nut, DNA moved onto the Ultimate Rap League and debuted against Oun P. Since then, DNA has faced top-tier opponents such as T-Rex, Tsu-Surf, Young Ill, X-Factor, Big T, Tech 9, as well as the highly publicized match against Dizaster at KOTD: Flatline. With his sharp wordplay, rapidfire delivery, and uncanny freestyle ability, DNA has shown that he is able to win over any crowd, even when the odds are seemingly against him. Eurgh will be DNA's first overseas opponent, and his second battle for KOTD. Ever since he entered the JumpOff WRC Qualifiers in 2007 at the age of 17, Eurgh has been a force to be reckoned with. At the time, known simply as Arkaic's partner, Eurgh made his mark with his lyrical wit, and also for his infamous angry speech after discovering that he and his partner would not be going to the finals. Since then, however, Eurgh has become a forerunner in the British battle scene, starting Don't Flop in 2008 with fellow rapper Cruger, a league that has ...

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KOTD - Rap Battle - DNA vs Eurgh - Video

Posted in DNA

Sperm of smoking dads can hurt child DNA

BRADFORD, England, June 24 (UPI) -- Men who smoke before conception can damage the DNA of their offspring in the womb that may give him or her a higher risk of disease, British researchers say.

Diana Anderson of the School of Life Sciences at the University of Bradford in England, and colleagues found evidence showing why men should be urged to stop smoking before trying to conceive in the same way women have been urged to quit tobacco.

A fertile sperm cell takes about three months to fully develop; therefore men would ultimately need to quit smoking long before conception to avoid causing genetic problems, Anderson said.

Anderson and colleagues used DNA biomarkers to measure genetic changes in the paternal blood and semen around conception, as well as maternal and umbilical cord blood at delivery in families from two different European regions in central England and a Greek island.

Information regarding the lifestyle, environmental and occupational exposures of these families was taken from validated questionnaires. The combined analysis of exposures and DNA biomarkers was used to evaluate the role of exposures before conception and during pregnancy in the causation of genetic changes in the offspring.

"These transmitted genetic changes may raise the risk of developing cancer in childhood, particularly leukemia and other genetic diseases," Anderson said in a statement. "We hope that this knowledge will urge men to cease smoking before trying to conceive."

The findings were published in the FASEB Journal.

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Sperm of smoking dads can hurt child DNA

Posted in DNA

Anatomy of a bottleneck

As tight spots go, the stretch of St. Clair West that ducks beneath the Georgetown rail corridor, between Old Weston Road and Keele Street, is as close to a traffic funnel as can be found anywhere in Toronto.

Densely populated neighbourhoods fan out to the east. To the west sit acres of car-friendly big box stores, with more on the way. Since construction this year closed a shortcut around the area, cars, buses and trucks crawl through the underpass, which offers one lane in either direction. Streetcars use a dedicated right-of-way.

You stand here for a little while and youll get a glimpse of what the people deal with everyday, Don Panos, chair of the St. Clair Gardens BIA, said recently as he stood at the corner of Old Weston, watching trucks trying to make tight right turns as cars backed up towards Caledonia. You just see how frustrating it is.

Council is considering how best to break the logjam, recently voting for an environmental assessment. One idea, favoured by the areas representative, Cesar Palacio, is to add two lanes to the underpass, but its a highly complex venture that would take years to complete and would cost more than $30-million.

Traffic engineers say the problem isnt just the width of the underpass; it also involves the constricted layout of busy intersections at either end, which regulate the volume of traffic passing beneath the 80-year-old bridge.

During the construction of the right-of-way, the intersections were not built according to approved designs because the city wanted to cut the cost of the land acquisitions needed to widen parts of the roadway, TTC experts said.

We have intersections that are not designed in accordance to what was agreed to, said TTC service planning manager Mitch Stambler. Decisions were made that were outside the planning and EA process by the construction managers.

Gord MacMillan, the citys director of design and construction, acknowledged that pressure to complete the project made it impossible to buy the additional strips of land for new turn lanes. As well, city project managers encountered technical problems that didnt surface during the planning process, he said.

Its impossible to know if the original design would have eased congestion. Yet the question is not moot. Traffic will swell in coming years with waves of new development. Metrolinxs Air Rail Link, slated to run on the Georgetown corridor starting in 2015, will make it much more complicated to rebuild the underpass once it is operating.

How to open the bottleneck:

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Anatomy of a bottleneck

China Medical Services Market Seen Hitting $500 Billion

By Bloomberg News - 2012-06-24T16:00:00Z

China, where 260 million people suffer from cancer, diabetes and other diseases, is in a hurry to bolster its medical services. Investors are ready to help.

The latest is Carlyle Group LP-backed Concord Medical Services Holdings Ltd. (CCM), which last week completed a deal for a 52 percent stake in Changan Hospital, a 1,000-bed facility at the eastern end of the Silk Road. The acquisition comes three months after China announced it wants 20 percent of its hospital beds privately owned by 2015. Other investors in China include Kuala Lumpur-based IHH Healthcare Bhd. (IHH), Asias biggest hospital operator, which plans to build a hospital in Shanghai, to add to seven clinics it owns in Shanghai and one in Chengdu.

The push for private hospitals in China is part of a broader drive to improve care in a country where 95 percent of people had health insurance as of 2011. Chinas medical services market is growing 18 percent annually and projected to reach 3.16 trillion ($500 billion) in 2015, accountancy firm Deloitte China said.

Chinas gross domestic product has grown by leaps and bounds, but the quality of medical care has lagged far behind, said David Chow, chairman of Harvest Medical Investment and Operation Group, a Taiwanese private equity firm thats planning to buy stakes in mainland hospitals this year. The potential for Chinas hospitals to improve is massive, both in the overall number of beds and the fees charged for each bed.

As of last year, China had 3.7 million hospital beds, up 54 percent from 2005. Besides an increase in the proportion of beds run by private operators -- it was 12 percent last year -- the government wants at least one or two hospitals in each of its 2,853 counties by the end of 2015, according to an outline of the countrys health-care policies.

Annual revenue from private hospitals in China may reach 2.4 trillion yuan ($377 billion) by 2015, said Yvonne Wu, national life science and health care industry leader at Deloitte China in Shanghai.

The targets could translate to 400,000 new private hospital beds over the next few years, said Roberta Lipson, chief executive officer of hospital operator Chindex International Inc. (CHDX)

U.S- and European-owned companies previously had a hard time entering the Chinese hospital market and tended to invest instead in clinics and diagnostic centers. They have only been able to independently invest in hospitals since Jan. 30, when the government took the industry off a so-called restricted list that required non-Chinese investors to have a local partner and capped foreign ownership at 70 percent.

Chindex, based in Bethesda, Maryland, started Chinas first foreign-owned hospital in Beijing in 1997, six years after commencing negotiations with the government, Lipson said. It took only a year to obtain a license to operate Chindexs latest hospital, in the port city of Tianjin, she said.

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China Medical Services Market Seen Hitting $500 Billion

Blood-brain barrier building blocks forged from human stem cells

Public release date: 24-Jun-2012 [ | E-mail | Share ]

Contact: Terry Devitt trdevitt@wisc.edu 608-262-8282 University of Wisconsin-Madison

MADISON -- The blood-brain barrier -- the filter that governs what can and cannot come into contact with the mammalian brain -- is a marvel of nature. It effectively separates circulating blood from the fluid that bathes the brain, and it keeps out bacteria, viruses and other agents that could damage it.

But the barrier can be disrupted by disease, stroke and multiple sclerosis, for example, and also is a big challenge for medicine, as it can be difficult or impossible to get therapeutic molecules through the barrier to treat neurological disorders.

Now, however, the blood-brain barrier may be poised to give up some of its secrets as researchers at the University of Wisconsin-Madison have created in the laboratory dish the cells that make up the brain's protective barrier. Writing in the June 24, 2012 edition of the journal Nature Biotechnology, the Wisconsin researchers describe transforming stem cells into endothelial cells with blood-brain barrier qualities.

Access to the specialized cells "has the potential to streamline drug discovery for neurological disease," says Eric Shusta, a UW-Madison professor of chemical and biological engineering and one of the senior authors of the new study. "You can look at tens of thousands of drug candidates and just ask the question if they have a chance to get into the brain. There is broad interest from the pharmaceutical industry."

The blood-brain barrier depends on the unique qualities of endothelial cells, the cells that make up the lining of blood vessels. In many parts of the body, the endothelial cells that line capillaries are spaced so that substances can pass through. But in the capillaries that lead to the brain, the endothelial cells nestle in tight formation, creating a semi-permeable barrier that allows some substances -- essential nutrients and metabolites -- access to the brain while keeping others -- pathogens and harmful chemicals -- locked out.

The cells described in the new Wisconsin study, which was led by Ethan S. Lippmann, now a postdoctoral fellow at the Wisconsin Institute for Discovery, and Samira M. Azarin, now a postdoctoral fellow at Northwestern University, exhibit both the active and passive regulatory qualities of those cells that make up the capillaries of the intact brain.

The research team coaxed both embryonic and induced pluripotent stem cells to form the endothelial cells of the blood-brain barrier. The use of induced cells, which can come from patients with specific neurological conditions, may be especially important for modeling disorders that compromise the blood-brain barrier. What's more, because the cells can be mass produced, they could be used to devise high-throughput screens for molecules that may have therapeutic value for neurological conditions or to identify existing drugs that may have neurotoxic qualities.

"The nice thing about deriving endothelial cells from induced pluripotent stem cells is that you can make disease-specific models of brain tissue that incorporate the blood-brain barrier," explains Sean Palecek, a UW-Madison professor of chemical and biological engineering and a senior author of the new report. "The cells you create will carry the genetic information of the condition you want to study."

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Blood-brain barrier building blocks forged from human stem cells

Gene mutations cause massive brain asymmetry

ScienceDaily (June 24, 2012) Hemimegalencephaly is a rare but dramatic condition in which the brain grows asymmetrically, with one hemisphere becoming massively enlarged. Though frequently diagnosed in children with severe epilepsy, the cause of hemimegalencephaly is unknown and current treatment is radical: surgical removal of some or all of the diseased half of the brain.

In a paper published in the June 24, 2012 online issue of Nature Genetics, a team of doctors and scientists, led by researchers at the University of California, San Diego School of Medicine and the Howard Hughes Medical Institute, say de novo somatic mutations in a trio of genes that help regulate cell size and proliferation are likely culprits for causing hemimegalencephaly, though perhaps not the only ones.

De novo somatic mutations are genetic changes in non-sex cells that are neither possessed nor transmitted by either parent. The scientists' findings -- a collaboration between Joseph G. Gleeson, MD, professor of neurosciences and pediatrics at UC San Diego School of Medicine and Rady Children's Hospital-San Diego; Gary W. Mathern, MD, a neurosurgeon at UC Los Angeles' Mattel Children's Hospital; and colleagues -- suggest it may be possible to design drugs that inhibit or turn down signals from these mutated genes, reducing or even preventing the need for surgery.

Gleeson's lab studied a group of 20 patients with hemimegalencephaly upon whom Mathern had operated, analyzing and comparing DNA sequences from removed brain tissue with DNA from the patients' blood and saliva.

"Mathern had reported a family with identical twins, in which one had hemimegalencephaly and one did not. Since such twins share all inherited DNA, we got to thinking that there may be a new mutation that arose in the diseased brain that causes the condition," said Gleeson. Realizing they shared the same ideas about potential causes, the physicians set out to tackle this question using new exome sequencing technology, which allows sequencing of all of the protein-coding exons of the genome at the same time.

The researchers ultimately identified three gene mutations found only in the diseased brain samples. All three mutated genes had previously been linked to cancers.

"We found mutations in a high percentage of the cells in genes regulating the cellular growth pathways in hemimegalencephaly," said Gleeson. "These same mutations have been found in various solid malignancies, including breast and pancreatic cancer. For reasons we do not yet understand, our patients do not develop cancer, but rather this unusual brain condition. Either there are other mutations required for cancer propagation that are missing in these patients, or neurons are not capable of forming these types of cancers."

The mutations were found in 30 percent of the patients studied, indicating other factors are involved. Nonetheless, the researchers have begun investigating potential treatments that address the known gene mutations, with the clear goal of finding a way to avoid the need for surgery.

"Although counterintuitive, hemimegalencephaly patients are far better off following the functional removal or disconnection of the enlarged hemisphere," said Mathern. "Prior to the surgery, most patients have devastating epilepsy, with hundreds of seizures per day, completely resistant to even our most powerful anti-seizure medications. The surgery disconnects the affected hemisphere from the rest of the brain, causing the seizures to stop. If performed at a young age and with appropriate rehabilitation, most children suffer less language or cognitive delay due to neural plasticity of the remaining hemisphere."

But a less-invasive drug therapy would still be more appealing.

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Gene mutations cause massive brain asymmetry

Hairston lauds chemistry of unselfish Dodgers

ANAHEIM -- The Dodgers are aware of the perception among outsiders that they are playing beyond their abilities in maintaining the lead in the National League West without Matt Kemp and Mark Ellis.

"We could care less what other people feel," versatile and productive veteran Jerry Hairston said. "Even when we were back in [Spring Training] camp, we felt we were going to be in every ballgame. Let's do things to win ballgames; that's how we looked at it. We've got to keep doing that.

"We have guys who know how to play the game, guys who have played a long time and been around the game their whole lives. We understand how to move a guy over, make the right play. Probably the most important part is the pitching; they've kept us in ballgames.

"We always pull for each other. It's a very unselfish group."

Hairston, who drove in one of the runs in a 3-1 victory over the Angels on Saturday and was given Sunday off by manager Don Mattingly, is batting .300 since returning from the DL (left hamstring strain) on May 25. He has started 37 games at four positions and is clutch with a .353 average from the seventh inning on.

ANAHEIM -- A versatile bench filled with veteran role players is more essential in the National League game, with its late-game maneuvering, than in the American League with its designated hitter. The Dodgers have loaded manager Don Mattingly's bench with a group of coolly competitive athletes fully aware of their roles.

"There is a thought to it," Mattingly said before Sunday's Interleague finale against the Angels. "The guys we brought in, we feel like they are kind of role players now. We wanted to make sure they've accepted that first, that you're not going be an everyday player."

Jerry Hairston, Adam Kennedy and Matt Treanor were free-agent acquisitions, while Bobby Abreu arrived after the Angels released him. Elian Herrera has shaken off the stereotype of career Minor Leaguer to emerge as an invaluable all-purpose player. Brilliant defensively with enough offense to hold his own, Tony Gwynn is as good as any fourth outfielder in the game.

"We can mix and match off the bench," Mattingly said. "With Jerry Hairston and Adam Kennedy, they're not coming in trying to knock somebody off his perch. They're good with playing four times out of seven [games]. In the National League game, you're in every game. You want guys who want to be in winning environments, playing for something -- not guys who are just playing out a year."

Hairston feels Abreu's role sliding into the No. 3 spot in the order in Matt Kemp's absence has been especially important. The Dodgers are 9-6 with Abreu hitting third, the role he's spent most of his career in while racking up borderline Hall of Fame numbers.

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Hairston lauds chemistry of unselfish Dodgers

Anatomy of a bottleneck

As tight spots go, the stretch of St. Clair West that ducks beneath the Georgetown rail corridor, between Old Weston Road and Keele Street, is as close to a traffic funnel as can be found anywhere in Toronto.

Densely populated neighbourhoods fan out to the east. To the west sit acres of car-friendly big box stores, with more on the way. Since construction this year closed a shortcut around the area, cars, buses and trucks crawl through the underpass, which offers one lane in either direction. Streetcars use a dedicated right-of-way.

You stand here for a little while and youll get a glimpse of what the people deal with everyday, Don Panos, chair of the St. Clair Gardens BIA, said recently as he stood at the corner of Old Weston, watching trucks trying to make tight right turns as cars backed up towards Caledonia. You just see how frustrating it is.

Council is considering how best to break the logjam, recently voting for an environmental assessment. One idea, favoured by the areas representative, Cesar Palacio, is to add two lanes to the underpass, but its a highly complex venture that would take years to complete and would cost more than $30-million.

Traffic engineers say the problem isnt just the width of the underpass; it also involves the constricted layout of busy intersections at either end, which regulate the volume of traffic passing beneath the 80-year-old bridge.

During the construction of the right-of-way, the intersections were not built according to approved designs because the city wanted to cut the cost of the land acquisitions needed to widen parts of the roadway, TTC experts said.

We have intersections that are not designed in accordance to what was agreed to, said TTC service planning manager Mitch Stambler. Decisions were made that were outside the planning and EA process by the construction managers.

Gord MacMillan, the citys director of design and construction, acknowledged that pressure to complete the project made it impossible to buy the additional strips of land for new turn lanes. As well, city project managers encountered technical problems that didnt surface during the planning process, he said.

Its impossible to know if the original design would have eased congestion. Yet the question is not moot. Traffic will swell in coming years with waves of new development. Metrolinxs Air Rail Link, slated to run on the Georgetown corridor starting in 2015, will make it much more complicated to rebuild the underpass once it is operating.

How to open the bottleneck:

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Anatomy of a bottleneck

How to Travel The World and Get Paid For IT? WELL, Here’s 1 Way… – Video

23-06-2012 11:12 16 Ways To Get Paid To Travel - Business Insider by Gus Lubin - More by Gus Lubin May 10, 2011 -- Go Inside The World's First Lab That Turns DNA Into Custom Art ... The raw amateur looking to get paid to travel may consider writing reviews ... Get Paid to See the World: 12 of the Best Jobs that Combine Work ... › Articles Jun 8, 2011 -- Some people simply don't want to quit their jobs to travel. It's quite risky, and if you aren't in the position to do so but still want to travel, then ... 5 Steps to World Travel and Getting Paid to Do What You Love ... Nov 10, 2010 -- (Warning: there are no pretty pictures in this post. You've been getting distracted too easily recently and this is important) ... How to Travel the World and Get Paid | › Vacations & Travel Planning Who wouldn't love to travel the world and get paid in the process? That seems to be a dream of many people. They love traveling, but they just can't afford to ... How can I get paid to travel the world? - Yahoo! Answers › ... › Travel › Travel (General) › Other - Destinations 11 answers - Aug 28, 2006 Top answer: If you're qualified, you could apply to be a US State Department foreign service diplomatic courier. For eligibility, salary range and additional ... Get paid to travel the world ...

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How to Travel The World and Get Paid For IT? WELL, Here's 1 Way... - Video