Cell transplantation of lung stem cells has beneficial impact for emphysema

Public release date: 4-Jun-2012 [ | E-mail | Share ]

Contact: David Eve Celltransplantation@gmail.com Cell Transplantation Center of Excellence for Aging and Brain Repair

Tampa, Fla. (June 4, 2012) When autologous (self-donated) lung-derived mensenchymal stem cells (LMSCs) were transplanted endoscopically into 13 adult female sheep modeled with emphysema, post-transplant evaluation showed evidence of tissue regeneration with increased blood perfusion and extra cellular matrix content. Researchers concluded that their approach could represent a practical alternative to conventional stem cell-based therapy for treating emphysema.

The study is published in Cell Transplantation (21:1), now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/.

"Mensenchymal stem cells are considered for transplantation because they are readily available, highly proliferative and display multi-lineage potential," said study corresponding author Dr. Edward P. Ingenito of the Brigham and Women's Hospital Division of Pulmonary and Critical Care Medicine. "Although MSCs have been isolated from various adult tissues - including fat, liver and lung tissues - cells derived from bone marrow (BM) have therapeutic utility and may be useful in treating advanced lung diseases, such as emphysema."

However, according to the authors, previous transplantation studies, many of which used an intravenous delivery method, have shown that BM-MSCs have been only marginally successful in treating lung diseases. Further, therapeutic responses in those studies have been limited to animal models of inflammatory lung diseases, such as asthma and acute lung injury.

To try and answer the questions surrounding the utility of BM-MSCs for treating advanced emphysema, a disease characterized by tissue destruction and loss of lung structural integrity, for this study the researchers isolated highly proliferative, mensenchymal cells from adult lung parenchyma (functional tissue) (LMSCs) and used an endoscopic delivery system coupled with a scaffold comprised of natural extracellular matrix components.

"LMSCs display efficient retention in the lung when delivered endobronchially and have regenerative capacity through expression of basement membrane proteins and growth factors," explained Dr. Ingenito.

However, despite the use of autologous cells, only a fraction of the LMSCs delivered to the lungs alveolar compartment appeared to engraft. Cell death likely occurred because of the failure of LMSCs to home to and bind within their niche, perhaps because the niche was modified by inflammation or fibrosis. These cells are attachment-dependent and failure to attach results in cell death."

Their findings did suggest, however, that LMSCs were capable of contributing to lung remodeling leading to documented functional improvement rather than scarring 28 days post transplantation.

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Cell transplantation of lung stem cells has beneficial impact for emphysema

Mature liver cells may be better than stem cells for liver cell transplantation therapy

Public release date: 4-Jun-2012 [ | E-mail | Share ]

Contact: David Eve celltransplantation@gmail.com Cell Transplantation Center of Excellence for Aging and Brain Repair

Tampa, Fla. (June 4, 2012) After carrying out a study comparing the repopulation efficiency of immature hepatic stem/progenitor cells and mature hepatocytes transplanted into liver-injured rats, a research team from Sapporo, Japan concluded that mature hepatocytes offered better repopulation efficiency than stem/progenitor cells.

Until day 14 post-transplantation, the growth of the stem/progenitor cells was faster than the mature hepatocytes, but after two weeks most of the stem/progenitor cells had died. However, the mature hepatocytes continued to survive and proliferate one year after their implantation.

The study is published in Cell Transplantation (21:1), now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/.

"Cell-based therapies as an alternative to liver transplantation to treat liver disease have shown promise," said study corresponding author Dr. Toshihiro Mitaka of the Cancer Research Institute of the Sapporo Medical University School of Medicine, Sapporo, Japan. "However, the repopulation efficiency of two candidate cell sources - hepatic progenitor/stem cells and mature hepatocytes - had not been comprehensively assessed and questions concerning the efficiency of each needed to be resolved."

The researchers noted that the shortage of cell sources and the difficulties of cryopreservation have limited the clinical application of cell based therapies. Stem or progenitor cells have been considered candidate cells because they can expand in vitro and can be cryopreserved for a long time.

However, after transplantation into liver injured rats, the researchers found that stem/progenitor cells did not survive well and most of the transplanted cells had disappeared within two months. In contrast, the mature hepatocytes gradually repopulated the rat livers and continued doing so past one year.

The researchers noted that the sizes of the hepatocytes were not uniform.

"Unexpectedly, the small hepatocytes repopulated significantly less well than the larger ones," explained Dr. Mitaka. "We also found that serial transplantation did not enhance nor diminish the repopulation capacity of the cells to any significant degree."

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Mature liver cells may be better than stem cells for liver cell transplantation therapy

Red Sox’ Pedroia Ready To Play Tuesday

Dustin Pedroia #15 of the Boston Red Sox heads back to the dugout after striking out in the ninth inning against the New York Yankees on April 21, 2012 at Fenway Park in Boston, Massachusetts. The New York Yankees defeated the Boston Red Sox 15-9. (Photo by Elsa/Getty Images)

BOSTON (CBS) As the Boston Red Sox prepared to leave Toronto after taking two-of-three from the Blue Jays over the weekend, Dustin Pedroia had one thing on his mind.

Play Tuesday, Pedroia told the teams website Sunday afternoon.

Out for the last week with a tornabductormuscle in his right thumb, Pedroia was able to avoid a trip to the disabled list and is primed for a return. He resumed batting practice on Saturday, with the help of a special brace over his hand, and felt no discomfort or swelling on Sunday.

Roche: Jays Are A Joke For Retaliation On Youkilis

Now the Red Sox second baseman hopes to return Tuesday when they open a three-game series with the Baltimore Orioles in Boston.

When asked if the team had said he was good to go, Pedroia gave his usual Pedroia-like response.

They dont tell me anything, man. I play Tuesday, he told the Boston Herald.

Pedroia was nearly called upon over the weekend in Toronto, after short stop Mike Aviles was hit in the hand by a grounder during Bostons 7-4 win on Saturday. Manager Bobby Valentine said he was ready to put Pedroia in the game, as the team had no other infielders available on the bench.

But Aviles was able to remain in the game, and Pedroia glove in hand stayed on the bench.

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Red Sox’ Pedroia Ready To Play Tuesday

Red Heads to Hall of Fame: Sarah's Stories

Macon - The Naismith Basketball Hall of Fame in Springfield, MA recently inducted the All American Red Heads, the only women's team to receive such an honor. Created in Cassville in 1936, the group was a professional women's basketball team up until 1986. KOMU 8's Sarah Hill recently had a chance to interview these former athletes and for these mothers and grandmothers, a Hall of Fame induction isn't the Red Heads' only bragging right.

"Everyone had red hair. Only our hair dresser knew which ones was real," said Lynn Thomas, a former All American Red Head in the 1970's.

Thomas' team from 1971 to 1973 played 206 games and only lost 6 with 96 consecutive wins in 96 days.

"While the men we played were out resting at half time, we were out putting on a show," said Brenda O'Bryan Koester.

The Red Heads' greatest accomplishment might have to do with their children and grand children . The former players are also teaching the younger generation how to play. Krisha Burk, daughter of Kay Kay O'Bryan Burk, is learning how to do some of her mom's signature moves. Recently Krisha Burk received three medals in the Special Olympics 50 and 100 meter walk.

"She's been competing since she was 6 years old and she's 31 years old now," said Kay Kay Burk. "I still do a lot of things with her and she still loves to do a lot of things with me, especially when it comes to the All American Red Heads. She's part of it."

Far greater than any Hall of Fame induction is a mother proud of her daughter. Krisha is already learning from her mother by regularly sinking baskets. Krisha may be brunette but she shoots...like a red head.

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Red Heads to Hall of Fame: Sarah's Stories

NASA space shuttle embarks on voyage to New Jersey

The space agency's original prototype orbiter, Enterprise is scheduled to arrive at the Intrepid Sea, Air & Space Museum on the west side of Manhattan on Tuesday.

By Robert Z. Pearlman,SPACE.com / June 4, 2012

NASA's space shuttle Enterprise launched on a voyage Sunday (June 3), going where no space shuttle has gone before: New Jersey.

The space agency's original prototype orbiter, Enterprise is scheduled to arrive at the Intrepid Sea, Air & Space Museum on the west side of Manhattan on Tuesday (June 5). Leaving Sunday from New York's John F. Kennedy (JFK) International Airport where it was delivered atop a jumbo jet in late April, theshuttle was barged to Bayonne, N.J., as a layover on its way up the Hudson River.

Enterprise, having firstarrived in the Big Apple by airand setting sail Sunday by sea, is only missing the experience of traveling through space to complete the Intrepid's three modal themes. The first of NASA's space shuttles, Enterprise did not fly in orbit but instead was used for a series of approach and landing tests in the late 1970s. [Gallery: Enterprise Sails to New Jersey]

Enterprise embarks

On Saturday, a large crane was used to load the 57,000 pound (26,000 kilogram) prototype shuttle onto the open air flat bed barge, which, towed by tugboat, made the trip to the Garden State the next day. Spectators in Queens, Staten Island and Brooklyn, including at Coney Island, lined the shores to watch as Enterprise floated by.

Along the way, thespace shuttle Enterprisepassed under several crossings, its vertical stabilizer, or tail, clearing the Verrazano Bridge, for example, by a good margin. At others, including the Gil Hodges Memorial, the bridges needed to be raised to allow the shuttle to pass.

The shuttle will stay in Bayonne through Tuesday. On Monday, it'll be hoisted off its barge onto one equipped with a crane.

Enterprise arrives

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NASA space shuttle embarks on voyage to New Jersey

NASA gets 2 Hubble-size telescopes from spy agency

NASA has received a gift from an unexpected source: the U.S. satellite spy agency.

The space agency confirmed Monday that it has received a pair of giant identical telescopes from the National Reconnaissance Office (NRO), an agency within the Department of Defense that oversees the U.S.'s constellation of spy satellites.

The telescopes have mirrors similar in size to the famed Hubble Space Telescope, and the Washington Post reported that they also have a moveable secondary mirror for more focused images.

NASA says the intelligence agency built them and then decided it no longer needed them, a stark contrast to NASA, which is still struggling to build and finance its own next-generation telescope, the James Webb Space Telescope.

The transfer of the instruments from the NRO to NASA occurred last summer but was only recently declassified.

Even with this windfall, the cash-strapped space agency, which was forced to end its 30-year-shuttle program last year and has run over budget on the Webb telescope, has no money to launch the telescopes anytime soon.

NASA officials said on Monday they likely won't be in use until 2020 at the earliest, two years after the Webb telescope is scheduled to be launched.

For now, the gifted telescopes are of no use to NASA as they lack the cameras and instruments necessary for astronomy research.

The telescopes are currently in upstate New York.

Scientists hope NASA will repurpose one of the telescopes to study mysterious dark energy.

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NASA gets 2 Hubble-size telescopes from spy agency

NASA gets 2 Hubble-like telescopes

Its been a rough year for NASAs science program, with a major pullback in its Mars exploration program and continuing threats to cancel the James Webb Space Telescope.

Now comes news today that NASA has acquired two Hubble-like telescopes from the National Reconnaissance Office, the U.S. Government agency in charge of designing, building, launching, and maintaining Americas intelligence satellites.

These telescopes, which are identical, were built eight years after Hubble so they have greater capabilities, such as being able to image a field of view 100 times larger than Hubble. They are space-ready but were never used.

The newly acquired telescopes are a shorter, stubbier version of the Hubble shown above. (NASA)

This is a great opportunity for NASA, and Ill get to that in a moment, but stop and think about this for a moment. The Department of Defense has the kind of funding needed hundred of millions to billions of dollars, presumably to build not one, but two, Hubble-like optical telescopes and then never use them.

Also unanswered is what the telescopes might have been used for by the NRO, but one guesses it wasnt for probing the complexities of dark energy.

But thats what NASA wants them for. The telescopes fit the nature of the kind of instrument NASA needs to conduct its Wide-Field Infrared Survey Telescope mission, ranked as the top priority among large science mission in the countrys most recent survey of astronomy and astrophysics projects.

The telescopes are space-ready, but far from being a ready to launch project. They still need a spacecraft that includes power, communications, control and thermal protection systems, in addition to a launch vehicle and a means to control them from the ground.

Nevertheless the telescopes could provide a critical impetus to getting the WFIRST project moving forward.

It could be a real game changer for a project that was having trouble getting a lot of traction, said Alan Dressler, a Carnegie Institute astronomer who has studied the telescopes for astronomical use.

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NASA gets 2 Hubble-like telescopes

NASA gets two unneeded Hubble-sized spy telescopes

An image of the proposed WFIRST design, which may be changed radically thanks to a gift from a spy agency.

Today, news broke that the National Reconnaissance Office, which handles satellite-based surveillance, had agreed to transfer two space-capable telescope lens systems to NASA. At a press call held today, NASA administrators said that while most of the remaining structure for a space-based telescope would still have to be built, the gift could jump-start a planned infrared survey telescope called WFIRST. That is, if Congress allocates money to take advantage of the gift. But at best, the hardware won't be in orbit until the start of the next decade.

The NRO apparently decided that some of the hardware it designed and built for use in spy satellites (but did not place in orbit) would be superfluous for its current needs. Back in January of 2011, the agency got in touch with NASA and offered to transfer the hardware (along with the design and test data from its construction). Since then, NASA has been paying about $100,000 a year to store the two telescopes in Rochester, New York while it decides if and how it can use them.

The primary lenses of the system are 2.4 meters, the same size as the lens in Hubble. Paul Hertz, the director of NASA's Astrophysics Division, described the lenses as being a different shape, "more like a bowl than a shallow disk." They're also much lighter, having benefitted from decades of technology advances. The difference in shape makes these suitable for survey missions, as opposed to high-resolution images. Compared to the Hubble, they would give you "about [a] 100 times bigger area that you can image well."

After NASA's internal analysis, a good match was found between these capabilities and an existing project, the Wide Field Infrared Survey Telescope, or WFIRST. WFIRST is planned to achieve three different goals. Its general survey of the infrared sky should identify objects of interest that could then be examined by the James Webb Space Telescope, which would have a much higher resolving power. The second goal would be to track the distribution of early galaxies and supernovae, which would let us get a better grip on the properties of dark energy accelerating the expansion of the Universe.

The final focus of WFIRST is to provide an independent measure of the frequency and properties of exoplanets. As exoplanets travel between the Earth and distant galaxies, they can act as small gravitational lenses, distorting space in a way that causes a temporary brightening of the background galaxy. Since the degree of change in the incoming light depends on gravitational effects, it provides some information about the mass of the planet doing the lensing.

WFIRST is already in the planning stages, but documents from last year's interim report indicate that the team behind it was considering a 1.3m primary mirror. This means the NRO hardware would provide a significant boost. According to the people on the press call, designing the optical system for a space-based telescope is also the most complex and expensive portion of the development process, and the NRO hardware could save hundreds of millions of dollars.

That said, NASA would still have its work cut out for it. The optical system would need power, communications hardware, pointing systems, insulation, a camera, and many other pieces before it could provide usable data. Then it would need a launch vehicle, which, based on the size of the optical system, would need to be at least an Atlas-class launcher. Of course, the space launch market is changing rapidlya future version of SpaceX's Falcon was raised as a possible optionso this seems to be the least of NASA's worries. As someone on the call put it, there's an office that will take the specifications and "find us an appropriate ride."

Developing all the additional hardware, however, won't come cheap, and even if money were to become plentiful, NASA doesn't think WFIRST could be put in space before 2020. Under "plausible" budgets, 2024 is more likely. But NASA administrators would have to specifically ask for it, and Congress would have to allocate the money. All that NASA will say for now is that the appropriate committee staff members have been briefed.

In the meantime, the agency has to work within some limits imposed by the telescopes' history. It won't be able, for example, to release any pictures until after the lenses are covered by all that additional hardware. USA Today'sDan Vergano was given an image of the telescope that was used at a recent meeting of the National Research Council. The level of redaction indicates that there will be some significant limits on any NASA design teams.

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NASA gets two unneeded Hubble-sized spy telescopes

Spy agency bequeaths two satellites to NASA, free of charge

The National Reconnaissance Office is giving NASA two spare space telescopes free of charge, each potentially more powerful than the Hubble Space Telescope.

The United States' spy satellite agency is giving NASA two spare space telescopes free of charge, each potentially more powerful than the Hubble Space Telescope, NASA officials announced today (June 4).

The twospy satellite telescopeswere originally built to fly space-based surveillance missions for the National Reconnaissance Office (NRO), but will be repurposed by NASA for astronomical research instead. Their donation to NASA was revealed in a surprise announcement.

Both NRO space telescopes have a main mirror nearly 8 feet wide (2.4 meters), rivaling theHubble Space Telescope, and also carry a secondary mirror to enhance image sharpness, according to press reports. NASA's Hubble telescope is a space icon that has been beaming stunning photos to Earth for 22 years.

NASA and NRO officials did not elaborate on the original design or mission for the reconnaissance telescopes, though officialstold the Washington Postthat the earliest either of the instruments could be recycled into a new space telescope and launched into orbit would be 2020. Finding the funding necessary to refit and launch the telescopes is a major hurdle, officials said.

NASA hopes to use one of the new space telescopes to hunt for mysterious dark energy, an invisible force that scientists think is responsible for the accelerating expansion of the universe.

During a media teleconference today, NASA officials said the two telescopes have an appearance similar to the Hubble telescope: They are cylindrical in shape and covered in shiny reflective insulation. The two telescopes do not currently have names, they added.

The Hubble space telescope, which launched in 1990, is the size of a school bus and has become an astronomical icon. But Hubble is also aging. Since its launch, Hubble has been repaired or upgraded five separate times, most recently in 2009 when NASA astronauts paid the last-ever service call on the venerable instrument.

Eventually, Hubble will be decommissioned and then intentionally destroyed by plunging into Earth's atmosphere over the Pacific Ocean.

Currently, NASA has no plans to replace Hubble, which is primarily an optical observatory, with a similar instrument. The space agency's next big orbital observatory is the James Webb Space Telescope, an infrared-only telescope designed to peer deep into the universe's 13.7 billion-year history.

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Spy agency bequeaths two satellites to NASA, free of charge

Forsyth Tech Expands Nanotechnology Educational Leadership in North Carolina Through NanoProfessor Nanoscience …

SKOKIE, IL--(Marketwire -06/04/12)- NanoProfessor, a division of NanoInk, Inc. focused on nanotechnology education, announced today that Forsyth Technical Community College (Forsyth Tech) is expanding its nanotechnology educational leadership in North Carolina by integrating the NanoProfessor Nanoscience Education Program into its current nanotechnology curriculum. Students will have the opportunity to work with NanoInk's NLP 2000 Desktop NanoFabrication System, the first desktop nanofabrication system allowing students to quickly and easily build custom-engineered nanoscale structures with a wide variety of materials from biomolecules to metal nanoparticles using NanoInk's proprietary Dip Pen Nanolithography (DPN).

Forsyth Tech's two-year Associate of Applied Science in Nanotechnology degree is the only one of its kind with graduates in the American Southeast. Classes are held in the rapidly expanding Piedmont Triad Research Park in downtown Winston-Salem. The college is also home to one of the largest biotechnology programs in the state.

"The NanoProfessor Program will not only enhance our existing nanotechnology curriculum, but it will enable students to conduct new, exciting hands-on lab experiments with NanoInk's NLP 2000 Desktop Nanofabrication System," said Kevin Conley, Program Coordinator of Nanotechnology Education at Forsyth Tech. "By expanding the skills and experience of our students as they work at the nanoscale, we will provide them with a competitive advantage for the rapidly growing number of nanobiotechnology jobs in North Carolina."

"We are extremely pleased that Forsyth Tech, a recognized leader in nanotechnology education, has selected the NanoProfessor Nanoscience Education Program to complement its already impressive nanotech curriculum," said Dean Hart, Chief Commercial Officer at NanoInk. "By training a nano savvy workforce, Forsyth Tech will not only help the state of North Carolina accomplish its mission of being a global leader in nanotechnology, but will also help the U.S. maintain leadership in the growing global nanotech market."

"Forsyth Tech and NanoProfessor are globally recognized for their pioneering work in nanotech education," said Griffith A. Kundahl, Executive Director of the Center of Innovation of Nanobiotechnology. "This announcement is great news for North Carolina which depends on an educated nanotech workforce to maintain its position as one of the strongest nano clusters in the world."

The NanoProfessor Nanoscience Education Program aims to expand hands-on nanotechnology education from the cleanrooms of research-based universities to the classrooms of undergraduate institutions, and is especially well-suited to nanotechnology educational initiatives at the community college, technical institute, and undergraduate university level. Alternating between classroom lectures and hands-on labs, the NanoProfessor Program provides students with the opportunity to learn the fundamentals for building custom-engineered nanoscale structures while working with state-of-the-art equipment including NanoInk's NLP 2000 Desktop NanoFabrication System, a student-friendly atomic force microscope, an advanced fluorescence microscope, a nanoparticle characterization instrument, and various chemical and biological materials used today within current and emerging nanotechnology applications.

Forsyth Tech, based in Winston-Salem, N.C., is one of the largest community colleges in the state and provides students with exceptional technical education and training, as well as college transfer, adult basic education, and continuing and corporate education programs. The college responds to student, employer, and community needs with innovative, flexible programs and service delivery. The Nanotechnology Degree Program is founded on the six pillars of Nanotechnology: Biology, Chemistry, and Physics, as well as Engineering, Economics, and Ethics. Program Coordinator of Nanotechnology Kevin Conley can be reached at kconley@forsythtech.edu or (336)734-7389. More information on the college is available at: http://www.forsythtech.edu.

Nanotechnology is the understanding and control of matter at dimensions between approximately one and 100 nanometers (nm), where unique phenomena enable novel applications not feasible when working with bulk materials. A nanometer is one-billionth of a meter. Encompassing nanoscale science, engineering, and technology, nanotechnology involves imaging, measuring, modeling, and manipulating matter at the nanoscale. A study funded by the National Science Foundation projects that six million nanotechnology workers will be needed worldwide by 2020, with two million of those jobs in the United States. However, as of 2008, there were only 400,000 estimated workers worldwide in the field of nanotechnology, with an estimated 150,000 of those in the United States.

About the NanoProfessor Nanoscience Education Program The NanoProfessor Nanoscience Education Program aims to advance undergraduate nanotechnology education and address the growing need for a skilled, nano-savvy workforce. The NanoProfessor Program, including instruments, an expert-driven curriculum, and student/teacher support materials, is available for high schools, community colleges, technical institutes, and universities worldwide. More information is available at http://www.NanoProfessor.net or (847)679-NANO (6266). You can also like NanoProfessor on Facebook at http://www.facebook.com/NanoProfessor1 and follow on Twitter at http://www.twitter.com/nanoprofessor1.

NanoInk, NanoProfessor, the NanoProfessor logo, Dip Pen Nanolithography, and DPN are trademarks or registered trademarks of NanoInk, Inc.

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Forsyth Tech Expands Nanotechnology Educational Leadership in North Carolina Through NanoProfessor Nanoscience ...

Subscriber Sundays – Introducing BigPumaGaming – Video

03-06-2012 13:05 Check out his channel: If you are interested in being featured on Subscriber Sunday, follow these instructions: 1) Create a great video introducing yourself to my subscribers, show them the game or games you play and let them know why they should check out your channel 2) Upload your video to YOUR channel and make sure you upload it UNLISTED 3) Once you have the video uploaded to YOUR channel UNLISTED, send me a YouTube message telling me you would like to be featured on Subscriber Sunday and send the link to your UNLISTED video 4) If your video is good enough, I will add it to the rotation Keep in mind if you do send something in, I have quite a few that still need to be featured so it may be a few weeks before you will see your video. If I get a ton of these I may start highlighting more then one channel per week. -----Important Info----- Don't forget to check out my new website, Yeousch Sports Yeousch Twitch: Follow me on Twitter: Like me on Facebook: Subscribe to my Live Stream Channel: Like FPS games? Subscribe to my other channel:

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Subscriber Sundays - Introducing BigPumaGaming - Video

Prison of the Mind – Video

04-06-2012 02:38 I have had this kicking around for some time now and thought I should just upload it. It was just an idea I was messing around with at the time so I see no harm in putting it out there. Remix, use, spread and do what you want with it. If you are interested in working with like minded people then head over to these places. And remember always be peaceful in every thing you do and keep on talking. Peace Stonehart.

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Prison of the Mind - Video

China bans Tiananmen web searches

4 June 2012 Last updated at 11:12 By Katia Moskvitch Technology reporter, BBC News

Chinese authorities have blocked internet access to search terms related to the 23rd anniversary of the 1989 crackdown against protesters at Beijing's Tiananmen Square.

Terms such as "six four", "23", "candle" and "never forget", typed in Chinese search engines, do not return any information about the event.

Discussions of the unrest of 4 June 1989 remain taboo in the country.

But some users managed to upload a few pictures on to Twitter-like Sina Weibo.

In 1989, troops shot dead hundreds of pro-democracy protesters gathered in central Beijing.

The demonstrations have never been publicly marked in China, and the government has never said how many were killed.

But human rights groups' estimates range from several hundred to several thousand killed.

For most Chinese the words 'Tiananmen square' don't bring to mind the same images and associations as in the West

Analysts say that censoring any online talk related to the event is especially important for Beijing this year, as the government gets ready for a leadership handover.

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China bans Tiananmen web searches

PSOW Rolls Out 6th National Business Etiquette Week (June 3-9, 2012) Offering Advice For The Digital Age – 76% of HR …

NEW YORK, June 4, 2012 /PRNewswire/ -- "Today, a 'text' is no longer a book, it's a mobile application," says Pamela Eyring, President of The Protocol School of Washingtonwww.psow.edu, global leader in business etiquette, image and international protocol training. Ms. Eyring should know. Over the past several years she has witnessed first-hand the global shift in how business gets done. "When we launched National Business Etiquette Week in 2007, we talked about the 'evergreen etiquette' of business such as how you greet someone and how you dress. Today, 'evergreen etiquette' is just as important, but increasingly the world is conducting business 24/7 on mobile devices - we need to add 'mobile manners' to the mix," says Ms. Eyring. As PSOW celebrates the 6th Annual National Business Etiquette Week, June 3-9, 2012, Ms. Eyring offers e-advice for those in business, the government and academia, noting that: "According to a recent poll of 750 human resource managers by global staffing behemoth Robert Half, 76 percent of HR managers say technology etiquette breaches adversely affect one's career prospects."

e-Advice from The Protocol School of Washington

The first company to offer business etiquette training in 1988, today PSOW is the only nationally accredited business etiquette, image and international protocol school in the nation, and is the acknowledged leader in business etiquette and protocol training with more than 3,500 graduates from 58 countries. Formerly the Chief of Protocol at Wright-Patterson Air Force Base in Ohio, Ms. Pamela Eyring has worked with heads of state, CEOs of the Fortune 500 and four-star generals. After purchasing the school in 2006, Ms. Eyring expanded PSOW in 2009, taking it overseas, holding courses in Dubai, Trinidad & Tobago, and Turkey. PSOW trainers hail from The White House, the Disney Institute, the Smithsonian and corporate America.

PSOW recommends business people on all levels, in every country, mind their mobile Ps & Qs not just during National Business Etiquette Week, but every week of the year.

info@psow.edu

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PSOW Rolls Out 6th National Business Etiquette Week (June 3-9, 2012) Offering Advice For The Digital Age - 76% of HR ...