SEATTLE, WA--(Marketwire -06/13/12)- Integrated Diagnostics (InDi), an emerging leader in molecular diagnostics, today announced that the company has launched a new operating division, InDi Imaging, that is creating a new generation of PET imaging probes using the company's innovative protein catalyzed capture (PCC) agent technology. PCCs, initially developed for in vitro molecular diagnostics, will be employed as rationally designed, in vivo diagnostic imaging probes that mimic the properties of antibodies and biologics in PET molecular imaging, with the benefit of being chemically stable, synthetic small-molecules.

Concurrently, the company announced that it has appointed Norman Hardman, Ph.D. as the president of InDi Imaging. Dr. Hardman, a well-respected biotechnology executive, has a long track record of successfully commercializing new molecular technologies. The company also announced that Michael Phelps, Ph.D., Norton Simon Professor, chairman of the UCLA Department of Molecular and Medical Pharmacology and the inventor of PET, has been appointed to InDi Imaging as an advisor. Integrated Diagnostics' other division, InDi Dx, will continue to focus on in vitro diagnostic medicine. Its first diagnostic test, a blood based protein test for the detection of lung cancer in patients with intermediate size pulmonary nodules, is scheduled for commercial launch in the first half of 2013.

"InDi Imaging is seeking to provide whole body imaging assays with PET of all tissues of the body to examine the primary tumor in cancers and metastases in different organs that are known to have different biological characteristics to supplant more conventional diagnostic modalities through real time imaging with PET using PCC technology," said Albert "Al" A. Luderer, Ph.D., CEO of Integrated Diagnostics. "Norm Hardman brings a wealth of experience and success in R&D, pharmaceuticals and biotech. I believe Norm is uniquely positioned to lead InDi Imaging as we create a new world of imaging products with PCC technology that are coupled to our in vitro blood based molecular diagnostics."

PCCs are stable, synthetic, rationally designed chemical compositions with small-molecule like properties designed to detect designated motifs on any target protein through chemical diversity in the PCCs for arrays of protein targets. InDi licensed PCCs from the California Institute of Technology (Caltech). The technology is based on inventions pioneered by Jim Heath, Ph.D., a Caltech and UCLA professor, InDi co-founder and board member. The team at InDi, under the direction of Paul Kearney, Ph.D., the company's president, CSO, and co-founder, is adapting PCCs for in vivo diagnostic imaging applications. PCCs are manufactured using "click chemistry," a process that allows scientists to join ("click") together molecular components with unusual precision and stability with high selectivity to the target protein. InDi has obtained a license to use click chemistry from the Scripps Research Institute. The company plans to pursue the first human studies of its PCC-based imaging products over the next 12-18 months.

"PCCs are incredibly versatile because they are built using the principles of modular chemistry. That means they can be optimized for use as in vivo imaging PET probes, enabling us to simultaneously pursue multiple disease targets in a way that is difficult or impossible using more traditional antibody- or phage-display approaches," said Dr. Hardman. "I am very excited to join Al, Jim, Paul and the rest of the InDi team in developing new imaging products that will be clinically significant and commercially successful. I'm also looking forward to working closely with Dr. Phelps in the application of PCC technology to develop the next-generation of imaging probes with superior performance in PET imaging and informative diagnosis of the biology of disease in patients."

Dr. Phelps is the inventor of PET, a molecular imaging technique that provides in vivo images of biological processes, blood flow, metabolism, cell communication systems, drug interactions and gene expression. The technology has many important clinical applications in the diagnosis of human disease, and monitoring of therapeutic modalities. There are 2,400 clinical PET imaging centers in America, as well as PET clinical services throughout the rest of the world. While uniquely providing molecular imaging diagnostics of disease, the unique principles of PET have provided its molecular imaging diagnostics in approximately 37 million clinical studies without a single reported complication.

"We are very pleased to welcome Dr. Michael Phelps as an advisor to InDi Imaging," said Dr. Luderer. "He is an unparalleled scholar and entrepreneur in molecular imaging whose counsel will be essential to the technical and clinical success of PCC technology as an innovative new approach to molecular diagnostic imaging of disease."

About Dr. Hardman

Prior to joining Integrated Diagnostics, Dr. Hardman was the president and CEO of Oxalis Partners, a strategic consultancy to US and EU biotechnology companies and venture capital firms. He is currently non-executive director of Chelsea Therapeutics, Inc. and has previously held senior management roles in several US-based biotechnology companies, including: president and CEO of Amicus Therapeutics; CEO of the UK Medical Research Council (MRC) Technology Transfer organization; senior VP of technology for Enzon Pharmaceuticals; COO of Onyx Pharmaceuticals; and president and COO of GeneMedicine.

Earlier in his career, Dr. Hardman served as head of R&D at Ciba-Geigy UK and played a central role in the integration of the global R&D organization during the merger of Ciba-Geigy and Sandoz to form Novartis AG, becoming head of UK R&D Operations in the merged entity. He has been involved at various stages in the R&D of several important pharmaceutical products, including: Gleevec, Xolair, Nexavar, Amigal and Plicera.

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Integrated Diagnostics(R) Launches Imaging Division to Create PET Imaging Probes

CALGARY , June 13, 2012 /CNW/ - Oncolytics Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ:ONCY) announced today that a paper entitled "Cell Carriage, Delivery, and Selective Replication of an Oncolytic Virus in Tumor in Patients," has been published in the latest issue of the journal Science Translational Medicine (Vol. 4 Issue 138 138ra77).

The paper covers findings from a U.K. translational clinical trial (REO 013) investigating intravenous administration of REOLYSIN in patients with metastatic colorectal cancer prior to surgical resection of liver metastases. The paper was jointly first-authored by researchers from the Leeds Institute of Molecular Medicine, University of Leeds , UK and The Institute of Cancer Research, London , UK.

The trial was an open-label, non-randomized, single centre study of REOLYSIN given intravenously to patients for five consecutive days in advance of their scheduled operations to remove colorectal cancer metastasis in the liver. Ten patients were treated with intravenous REOLYSIN at 1x1010 TCID50, one to four weeks prior to planned surgery. After surgery, the tumor and surrounding liver tissue were assessed for viral status and anti-tumor effects.

The researchers demonstrated that even though all the treated patients had preexisting immunity to the virus, intravenously administered reovirus could still specifically target and infect metastatic liver tumors in 90% of the patients. The researchers were able to determine that reovirus was able to evade these neutralizing effects of the immune system by binding to specific blood cells that would in turn deliver the virus to the tumor. Analysis of surgical specimens demonstrated greater, preferential expression of reovirus protein in malignant cells compared to either tumor stroma or surrounding normal liver tissue. There was evidence of viral factories within tumor and recovery of replicating virus from tumor (but not normal liver) in all four patients from whom fresh tissue was available. This is the first time that researchers have been able to demonstrate in patients treated with intravenously delivered oncolytic virus, that a virus could cloak itself from neutralizing antibodies after systemic administration through blood cell carriage and specifically target tumor tissue.

"These are key findings that directly further our understanding of how REOLYSIN interacts with the human immune system and retains its cytotoxicity in the body following intravenous administration," said Dr. Brad Thompson , President and CEO of Oncolytics. "It also highlights the reovirus' unique ability to target cancer cells, and create viral factories within tumor cells, without harming normal, healthy tissue."

"We believe this trial is a key step forward for virotherapy," said Dr. Alan Melcher , Professor of Oncology and Biotherapy at the University of Leeds , UK. "For the first time it shows in patients that intravenously injected reovirus selectively targets cancer, but not normal tissue, for replication and tumor cell killing. It also shows that even when anti-viral antibodies are present in the circulation, the virus can evade neutralization by "hitch-hiking" on blood cells to reach its tumor target."

One of the UK's largest medical, health and bioscience research bases, the University of Leeds delivers world leading research in medical engineering, cancer, cardiovascular studies, epidemiology, molecular genetics, musculoskeletal medicine, dentistry, psychology and applied health. Treatments and initiatives developed in Leeds are transforming the lives of people worldwide with conditions such as diabetes, HIV, tuberculosis and malaria. http://www.leeds.ac.uk.

The Institute of Cancer Research (ICR) is one of the world's most influential cancer research institutes. Scientists and clinicians at the ICR are working every day to make a real impact on cancer patients' lives. Through its unique partnership with The Royal Marsden Hospital and 'bench-to-bedside' approach, the ICR is able to create and deliver results in a way that other institutions cannot. Together the two organisations are rated in the top four cancer centres globally. The ICR has an outstanding record of achievement dating back more than 100 years. It provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today it leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment. As a college of the University of London , the ICR provides postgraduate higher education of international distinction. It has charitable status and relies on support from partner organisations, charities and the general public. The ICR's mission is to make the discoveries that defeat cancer. For more information visit http://www.icr.ac.uk.

The Royal Marsden NHS Foundation Trust The Royal Marsden opened its doors in 1851 as the world's first hospital dedicated to cancer diagnosis, treatment, research and education. Today, together with its academic partner, The Institute of Cancer Research (ICR), it is the largest and most comprehensive cancer centre in Europe treating over 44,000 patients every year. It is a centre of excellence with an international reputation for groundbreaking research and pioneering the very latest in cancer treatments and technologies. The Royal Marsden also provides community services in the London boroughs of Sutton and Merton and in June 2010 , along with the ICR, the Trust launched a new academic partnership with Mount Vernon Cancer Centre in Middlesex. Since 2004, the hospital's charity, The Royal Marsden Cancer Charity, has helped raise over 50 million to build theatres, diagnostic centres, and drug development units. Prince William became President of The Royal Marsden in 2007, following a long royal connection with the hospital. For more information, visit http://www.royalmarsden.nhs.uk.

About Oncolytics Biotech Inc. Oncolytics is a Calgary-based biotechnology company focused on the development of oncolytic viruses as potential cancer therapeutics. Oncolytics' clinical program includes a variety of human trials including a Phase III trial in head and neck cancers using REOLYSIN, its proprietary formulation of the human reovirus. For further information about Oncolytics, please visit: http://www.oncolyticsbiotech.com.

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Oncolytics Biotech® Inc. Announces Publication of Translational Clinical Trial Results in Science Translational Medicine