Research and Markets: NBJ 2012 Global Supplement & Nutrition Industry Report

DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/wkv5lr/nbj_2012_global_su) has announced the addition of the "NBJ 2012 Global Supplement & Nutrition Industry Report" report to their offering.

The global nutrition industry- which Nutrition Business Journal defines as including all dietary supplements, natural & organic foods and beverages, functional foods and beverages, and natural & organic personal care & household products- has become a $300 billion global industry. In this report, NBJ will break down each of these segments and look at the sales data for all seven regions of the world.

Once every two years, Nutrition Business Journal compiles all research pertaining to the global supplement and nutrition industry into our most anticipated report. Our report provides market and sales data by global region through 2010, with projections up through 2016.

This year's Global Nutrition Industry Report includes:

- A timeline of nutrition industry developments tracing back over two centuries

- Data and analysis on the dietary supplement, natural & organic food, functional food, and natural & organic personal care markets worldwide

- An overview of both the challenges and the potential opportunities in the U.S. & Global markets

- Trend reporting and case studies on each of the seven global regions, including interviews with influential CEOs and worldwide thought leaders

- Profiles on the global industry's top 20 companies, including SWOT analyses and sales data.

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Research and Markets: NBJ 2012 Global Supplement & Nutrition Industry Report

Longevity Risk and Longevity Insurance for Pensions (Part 3) – Video

12-06-2012 07:26 In this live recording of an AEGON Global Pensions online seminar, Chris Madsen and Martijn Tans discuss the nature of longevity risk for pension funds and how companies can protect their pension funds against longevity risk. In part 3, Chris and Martijn discuss longevity insurance and how pension funds can protect against longevity risk.

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Longevity Risk and Longevity Insurance for Pensions (Part 3) - Video

Longevity Risk and Longevity Insurance for Pensions (Part 1) – Video

12-06-2012 07:27 In this live recording of an AEGON Global Pensions online seminar, Chris Madsen and Martijn Tans discuss the nature of longevity risk for pension funds and how companies can protect their pension funds against longevity risk. In part 1, Chris and Martijn discuss ageing populations and the use of stochastic modelling for assessing longevity risk. They also discuss the potential impact that longevity risk has on a typical company pension plan.

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Longevity Risk and Longevity Insurance for Pensions (Part 1) - Video

Venable most impressed with dad's longevity

ByCorey Brock/MLB.com|06/12/12 10:30 PM ET

SEATTLE -- With three hits on Sunday against the Brewers, Padres outfielder Will Venable surpassed his father, Max, with 339 career hits.

SEATTLE -- Carlos Quentin had the distinction of being the Padres' first designated hitter this season. Chances are, it will happen more often than not this week.

SEATTLE -- Three hours before Tuesday's game against the Mariners, a group of Padres relievers as well as bullpen catchers Griffin Benedict and Justin Hatcher and starting catcher Nick Hundley huddled for a quick video shoot to wish bullpen coach Darrel Akerfelds a happy 50th birthday.

Shortstop Everth Cabrera rejoined the Padres on Tuesday after his trial in Phoenix was canceled on Monday.

According to UT San Diego, prosecutors dismissed the case, which allowed for him to return to the team without missing any games. San Diego was off on Monday after flying late Sunday to Seattle from Milwaukee.

The trial was set for Monday to accommodate the Padres' off-day. Cabrera was charged with misdemeanor assault upon his wife, stemming from a March 16 incident in Glendale, Ariz.

Corey Brock is a reporter for MLB.com. Keep track of @FollowThePadres on Twitter. This story was not subject to the approval of Major League Baseball or its clubs.

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Venable most impressed with dad's longevity

Sleep helps predict pro athlete's longevity

BOSTON, June 13 (UPI) -- Studies involving NFL and MLB players suggest evaluating an athlete's sleep helps determine his or her professional longevity, U.S. researchers said.

Sleep researcher Dr. W. Christopher Winter said he uncovered a link between a pro athlete's longevity and the degree of sleepiness experienced in the daytime.

"A team's ability to accurately judge a prospect or a potential trade in terms of the value they will get for that player is what makes or breaks many professional sport teams," Winter, a sleep adviser for Men's Health magazine, said in a statement.

The study involving football looked at 55 randomly selected college players who reached the NFL. It found sleepier athletes had only a 38 percent chance of staying with the team that originally drafted them. In comparison, 56 percent of the less sleepy players were considered a "value pick" because they stayed with their original team.

The baseball study analyzed the sleepiness scale of 40 randomly selected players and found those who reported higher levels of daytime sleepiness had attrition rates of 57 percent to 86 percent, well above the 30 percent to 35 percent major league average.

"Addressing sleepiness in players and correcting the underlying issues causing sleepiness may help to prolong a player's career," Winter said.

Winter presented the two studies at Sleep, the 26th annual meeting of the Associated Professional Sleep Societies in Boston.

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Sleep helps predict pro athlete's longevity

No trace of DNA on wine bottle

KUANTAN: NO traces of accused, Asni Omars deoxyribonucleic acid (DNA) were found on the wine bottle alleged used in the murder of French tourist Stephanie Foray.

Chemist Nor Aidora Saedon, who took the witness stand at the trial yesterday, replied the above in response to a question by counsel Datuk Ng See Teong who is acting for 37-year-old petty trader Asni.

Ng: When the bottle was given to you, was it in the same condition as it is now?

Nor Aidora: Yes, it was in the same physical condition as shown in court now (referring to the stained Malibu wine bottle tendered as part of the prosecutions exhibits).

When Ng asked Nor Aidora if she had opened the bottle when she was performing the DNA profiling test, she replied no.

Ng: You did not open the bottle at all to analyse even its contents?

Nor Aidora: No, I did not.

Ng: What was the result you got from analysing the bottle?

Nor Aidora: No blood traces were found on the bottle.

Ng: Did you perform DNA profiling test on the bottle?

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No trace of DNA on wine bottle

Posted in DNA

DNA Scans Can Spot Cause of Brain Issue in 25% of Kids

By Robert Langreth - 2012-06-13T18:00:00Z

Scanning the genes of children with inherited brain disorders pinpoints the precise cause more than a quarter of the time, often changing the diagnosis, according to one of the largest studies of child DNA sequencing.

The study published today in Science Translational Medicine examined the genes in 118 people with child-onset brain development disorders where obvious causes had been excluded. Researchers found new disease-causing mutations in 22 patients. In 10 more people, the scans found rare genetic diseases that had been misdiagnosed because symptoms were atypical. In two cases, the new diagnosis led to changes in treatment.

The study is a remarkable demonstration of the power of sequencing in the clinic -- precise, molecular, root cause diagnosis, said Eric Topol, a professor of genomics at the Scripps Research Institute in San Diego in an e-mail. Virtually all diseases will be more precisely defined through gene sequencing in the not-too-distant future, he wrote.

The research shows how often DNA scans can improve diagnosis in kids with brain disorders such as autism, severe epilepsy, or intellectual disability, said Joseph Gleeson, a child neurologist and study author. Brain development disorders afflict as much as 4 percent of children and are often genetic, yet the precise causes can be elusive, he said. Sequencing lets researchers examine all genes for abnormalities, instead of testing for one genetic disorder at a time as done now.

The biggest surprise is that some children with genetic brain disorders have diseases that have been known for a long time, said Gleeson, of the University of California, San Diego. The kids werent diagnosed correctly because frequently their symptoms dont match those in the textbook.

As a consequence, doctors may not have thought of ordering gene tests for those rare diseases, Gleeson said.

This is taking the whole medical field by surprise, Gleeson said. It used to be that the gray-haired professor was the gold standard, and if patient didnt respond to treatment then patient was an anomaly.

Gene sequencing eliminates the problem of misleading or vague symptoms by testing all genes, Gleeson said. It will change the way we practice medicine, he said.

The study follows research published in the June issue of the Journal of Medical Genetics, where scientists at Duke University used sequencing to diagnose six of 12 kids with genetic disease of unknown origin. In five of the cases, the children had had mutations in genes known to cause disease, said David Goldstein, the study leader and director of the Center for Human Genome Variation at Dukes School of Medicine in Durham, North Carolina. One child had been diagnosed with autism, yet turned out to actually have Pitt-Hopkins Syndrome.

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DNA Scans Can Spot Cause of Brain Issue in 25% of Kids

Posted in DNA

DNA Brands selects Titan Distributors for Canadian foray

DBR Staff Writer Published 13 June 2012

US-based energy drink maker DNA Brands has entered into an exclusive agreement with Titan Distributors to expand its footprint in Canada.

The company manufactures DNA Energy Drink and DNA Shred Stix.

DNA Energy Drink is a proprietary blend of ingredients in four flavors - Citrus, Lemon Lime, Sugar Free Citrus and Cranrazberry.

DNA Brands president and CEO Darren Marks said that the company intends to support and grow the DNA name in Canada through conventional marketing initiatives including sampling programs, TV and radio, and by utilizing Titan's close relationships with premier athletes and celebrities to act as brand ambassadors and spokesmen

"An August launch is expected," Marks said.

Titan Distributors president and CEO David Coriaty said that the company looks forward to work hand-in-hand with DNA's dedicated management team to first ensure a successful product launch and ultimately a huge success throughout Canada.

Independent retailers throughout the US and national retailers including Walgreens, Race Trac and Circle K sell the DNA Brands products.

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DNA Brands selects Titan Distributors for Canadian foray

Posted in DNA

Scientists map DNA of our ape cousin

Behold the bonobo, our ape cousin that's kinder and gentler than the chimp or, well, us. Now scientists have mapped the primate's DNA, and some researchers say that may eventually reveal secrets about how the darker side of our nature evolved.

Scientists have found that we are as close genetically to the peace-loving but little-known bonobo as we are to the more violent and better understood chimpanzee. It's as if they are siblings and we are cousins, related to them both equally, sharing some traits with just bonobos and other characteristics with just chimps.

Bonobos and humans share 98.7 per cent of the same genetic blueprint, the same percentage shared with chimps, according to a study released on Wednesday by the journal Nature.

The two apes are much more closely related to each other - sharing 99.6 per cent of their genomes - said study lead author Kay Prufer, a geneticist at the Max Planck Institute in Germany.

'Humans are a little like a mosaic of bonobo and chimpanzee genomes.'

Bonobos and chimps have distinctly different behaviours that can be seen in humans, with bonobos displaying what might be thought of as our better angels, said Duke University researcher Brian Hare.

Bonobos make love, not war. Chimps have been documented to kill and make war.

Bonobos share food with total strangers, but chimps do not.

Bonobos stay close to their mothers - who even pick out their sons' mates - long after infancy like humans. But chimps tend to use tools better and have bigger brains, like humans.

'Is the bonobo genome the secret to the biology of peace?' asked Hare, who was not involved in the new research. 'They have done something in their evolution that even humans can't do. They don't have the dark side we do.

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Scientists map DNA of our ape cousin

Posted in DNA

Dechaine witness: Test more for DNA

1:00 AM That could clarify whether thumbnail DNA evidence came from contamination during the autopsy, he says.

By Ann S. Kim akim@mainetoday.com Staff Writer

PORTLAND - More testing of items from the investigation of Sarah Cherry's murder could help clarify whether the DNA found on one of her thumbnails came from contamination, a witness said Wednesday at a hearing on Dennis Dechaine's motion for a new trial.

click image to enlarge

Dennis Dechaine, right, and defense attorney Steven Peterson.

John Ewing/Staff Photographer

Swabs of certain items from the 1988 kidnapping and murder of the 12-year-old Bowdoin girl have already been tested for male DNA and come up negative. Those items include sticks that were used to assault the girl, the rope that bound her hands and the scarf that was over her mouth.

Witness Rick Staub, the forensics laboratory director of a company in Texas that handled some of the tests, testified that there could be value in doing additional DNA analysis on evidence in the case. If DNA similar to the thumbnail DNA was found on other items, it would make it unlikely that the thumbnail DNA came from contamination during the autopsy.

The partial DNA profile extracted from the girl's left thumbnail is at the center of Dechaine's attempt to get another trial. On Wednesday, his lawyer, Steve Peterson, continued to present witnesses' testimony aimed at convincing Superior Court Justice Carl Bradford that jurors would not have convicted Dechaine in 1989 had they known about the DNA.

One of those witnesses, Rick Staub, said it's hard to imagine that DNA was transferred to the thumbnail by clippers used in the autopsy -- as Deputy Attorney General William Stokes has argued is the most likely scenario -- unless the clippers had wet blood on them and were used immediately afterward.

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Posted in DNA

Agreement on DNA testing in Skinner case, but "key" evidence missing

DNA testing of evidence in the Henry Skinner triple murder case hit yet another snag this week as prosecutors admitted that a blood-stained windbreaker termed "perhaps the key piece of evidence" by the killer's lawyer cannot be found.

In a motion laying out terms of a joint agreement to begin testing filed late Tuesday, the state and Skinner attorney Rob Owen identify 40 items to be submitted for testing. Among them are clippings from a victim's fingernails, vaginal swabs, and knives found at the scene of the 1993 New Year's Eve Pampa murder.

Skinner, 50, was convicted of fatally bludgeoning his girlfriend, Twila Busby, and stabbing to death her two adult sons. He consistently has maintained his innocence, saying that consumption of codeine and alcohol had rendered him incapable of killing the victims.

Prosecutors in Tuesday's filing concede that the windbreaker, collected from the scene by the Pampa Police Department, has not been found.

"According to the state, every other single piece of evidence in this case has been preserved," Owen said in an email. "It is difficult to understand how the state has managed to maintain custody of items as small as fingernail clippings while apparently losing something as large as a man's windbreaker jacket. To date, the state has offered no explanation for its failure to safeguard evidence in this case."

A spokesman for the Texas Attorney General's Office declined immediate comment.

Owen said the jacket, which appears to be stained with perspiration and blood, may have been worn by the assailant. Owen said that, since the trial, a witness has identified the jacket as one worn by Busby's uncle.

That man, now dead, reportedly was seen stalking Busby at a party shortly before her murder.

Skinner has had at least two execution dates set. Last November, the Texas Court of Criminal Appeals issued a stay to ascertain how revised laws regarding such testing may apply to his case.

Skinner has endeavored for more than a decade to obtain DNA testing of seemingly important evidence gathered at the crime scene.

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Posted in DNA

Informatics, Biology Team Demonstrates Role of Foreign DNA Strands in Life-Supporting Bacteria

IU role in Human Microbiome Project exposes battle history between bacteria, viruses in human body

Newswise BLOOMINGTON, Ind. -- An Indiana University team of researchers has conducted the most in-depth and diverse genetic analysis of the defense systems that trillions of micro-organisms in the human body use to fend off viruses. The work is among a collection of 16 research papers released today by the Human Microbiome Project Consortium, a National Institutes of Health-led effort to map the normal microbial make-up of healthy humans.

CRISPRs

Led by IU Bloomington assistant professor of informatics and computing Yuzhen Ye, the team of bioinformaticists and biologists reconstructed arrays of clusters of regularly interspaced short palindromic repeats -- CRISPRs -- which function as immune systems to the bacteria that play a vital role in human health. Between genomic repeats, CRISPR locations carry short strands of foreign DNA called spacers, which provide a history of past exposures to outside invaders like plasmids and bacteriophages (viruses that infect bacteria), and allow the bacteria to fight off viruses they have already encountered.

"By studying CRISPRs and their sequences, we ask the same types of questions we ask about viral infections in humans and other animals: Do individuals make antibodies to a particular virus? If they do, we then know they have been exposed to that virus," Ye said. "By examining CRISPR sequences, we learn about what viruses there have been infecting different species of bacteria in a particular environment."

Bacteriophages are the most abundant life form on the planet and are in a constant arms race with bacteria, which in the human body outnumber human cells by 10 to 1. Scientists want to better understand how microbes -- a group that contributes more genes responsible for human survival than humans themselves do -- battle the viruses that seek to infect them.

Using a targeted assembly strategy to reconstruct CRISPR arrays that otherwise are impossible to identify from whole metagenome assemblies, the team identified the distributions of 64 known and 86 novel types of CRISPRs (based on the CRISPR repeat sequences) from the 751 shotgun datasets (containing 3.5 terabases of genomic sequences) of microbial DNA extracted from the 242 healthy U.S. volunteers participating in the Human Microbiome Project.

The Human Microbiome Project collected tissues from 15 body sites in 129 men and from 18 body sites in 113 females, with up to three samples taken from each volunteer's mouth, nose, skin and lower intestine, in addition to three vaginal sites in women. The entire research consortium included 200 researchers at nearly 80 universities and institutions, and today's release of new data is the result of five years of work and an investment of $173 million.

The IU team confirmed that by using targeted assembly, longer CRISPR arrays were produced that allowed more spacers to be identified for analyzing CRISPR evolution. The Streptococcus CRISPR SmutaL36, for example, was observed in 38 of 751 datasets using whole metagenome assembly, but targeted assembly identified SmutaL36 in 386 datasets. For 142 out of 150 CRISPRs, their traces were identified in more datasets by targeted assembly as compared to whole metagenome assembly, and for 36 CRISPRs, they were seen in at least 10 times more datasets. Enterococcus faecalis

"We know that CRISPRs adapted to a virus or other infectious agent are extremely important to the bacteria carrying those CRISPRs: They live or die," Ye said. "But we really don't understand how this leads to changes in the entire biology of an individual."

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Informatics, Biology Team Demonstrates Role of Foreign DNA Strands in Life-Supporting Bacteria

Brainiac: The history and science of doping

The return of the Olympics means that we'll get to enjoy some of those weird and delightful summer sports -- stuff like archery, handball, and synchronized swimming. Unfortunately, it also means the return of a thorny and frustrating subject: doping. In Run, Swim, Throw, Cheat, Chris Cooper, a professor of biochemistry at the University of Essex, provides an extraordinarily thorough account of the history and science of drugs in sports. We tend to think about doping in a relatively unsophisticated way, Cooper argues: It's bad, and we want to stop it. In fact, however, the science of doping is extraordinarily complex, and its history is nuanced and surprising. We need to understand doping better.

The first thing to grasp about doping, Cooper writes, is that, for most of history, no one's cared about it -- the idea of "doping" simply didn't exist. The ancient Greeks were entirely open about their use of nutritional and pharmaceutical aides: "Charmis of Sparta swore that dried figs led him to Olympic gold in 668 B.C.," Cooper writes, while the great Greek physician Galen "noted the positive benefits of eating herbs, mushrooms, and testicles." In 1904, runner Thomas Hicks won the St. Louis Olympic Marathon "on a combination of strychnine injections laced with brandy," and no one seemed to mind; in the inter-war years, scientists on both sides of the Atlantic openly and enthusiastically endorsed performance-enhancing drugs, including cocaine. In the 1930s, British soccer teams proudly boasted about the supplements they used: the Wolverhampton Wanderers, for example, "informed the media of their latest pharmaceutical tricks, publicizing their use of extracts of monkey glands in the newspaper the News of the World." Doping was banned at the Olympics in 1938, but still didn't have a real stigma -- professional athletes continued to use drugs.

For most of history, Cooper writes, "The debate, as far as we can judge, was about methods not morals. The view seemed to be that any way to obtain an edge was fine." Really, Cooper argues, it should come as no surprise that no one cared about doping: Ordinary people were enthusiastic about drugs in everyday life, too. In the 1940s and 50s, it was totally normal for a person to pop an amphetamine pill to boost his mood. It was only when society as a whole turned against drugs after the 1960s that doping in sports became a truly moral issue.

So we are still working out own attitudes toward doping, which are relatively recent -- and those attitudes must contend with the science of doping, which, Cooper shows, is equally double-edged. In the first place, it's hard to know what really works -- and, therefore, which offenses an athlete ought to be punished for. Clinical trials of performance-enhancing drugs, he points out, are of limited relevance to elite athletes, since they have bodies which differ in substantial ways from those of even very fit ordinary people. And, at the highest levels, elite athletes often possess built-in advantages which are 'unfair,' and which can be arranged on a spectrum along with pharmaceutical or nutritional advantages. Some athletes, for example, are "doped" by their genes -- like the Finnish skier Eero Mantyranta, who won seven Olympic medals, in part because he possessed a mutant gene which caused his body to over-produce EPO, a hormone which drives the production of red blood cells. EPO, as it happens, is also a performance-enhancing drug. Similarly, a small percentage of female athletes, Cooper points out, are born with hormonal profiles which give them unusual strength and speed. Above and beyond these issues, there's the fact of "technological doping" -- the benefits which an economically advanced home country can provide for an athlete-in-training.

Doping, in short, is complicated, and hard to talk about in a monolithic way. The only way to make sense of it is to think very carefully, on a case-by-case basis, about which sorts of interventions constitute effective, meaningful cheating. (Some doping interventions might in fact boil down to the placebo effect.) Unfortunately, our approach to doping is as inconsistent as our policy on recreational drugs. Caffeine, for example, has a demonstrable and substantial affect on athletic performance, and yet no one's outlawed it -- almost certainly because it's legal in civilian life. This suggests that many of our attitudes about doping may have little to do with sports. Instead, they proceed out of our moral concerns about drug use in general.

Cooper devotes most of the book to a fine-grained discussion of the science of doping, and shows that it's full of surprising wrinkles and exceptions. As a whole, his account suggests that we are not spending enough money and time to really understand the problem. Ultimately, he makes the case for a more empirical and pro-active approach to thinking about drugs in sports, driven by research. More research would help us anticipate new developments and concentrate on those doping practices which truly create unfairness. "We can no more 'win' a war on drugs in sport than we can 'win' a war on drugs in society," he concludes -- the best we can do is be informed, and to focus on increasing fairness, one case at a time.

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Brainiac: The history and science of doping

Tracking breast cancer cells on the move

Public release date: 14-Jun-2012 [ | E-mail | Share ]

Contact: Angela Hopp 240-283-6614 American Society for Biochemistry and Molecular Biology

Breast cancer cells frequently move from their primary site and invade bone, decreasing a patient's chance of survival. This process of metastasis is complex, and factors both within the breast cancer cells and within the new bone environment play a role. In next week's Journal of Biological Chemistry "Paper of the Week," Roger Gomis and colleagues at the Institute for Research in Biomedicine in Spain investigated how breast cancer cells migrate to bone.

In particular, they examined the role of NOG, a gene important to proper bone development. Previously, NOG was associated with bone metastasis in prostate cancer, but its specific role in breast cancer to bone metastasis remained unknown.

Gomis and colleagues showed that once breast cancer cells are on the move NOG enables them to specifically invade the bone and establish a tumor. It does this in two ways. First, NOG escalates bone degeneration by increasing the number of mature osteoclasts (bone cells that break down bone), essentially creating a spot in the bone for the metastatic breast cancer cells to take up residence. Second, NOG keeps the metastatic breast cancer cells in a stem-cell-like state, which enables them to propagate and form a new tumor in the bone environment.

Gomis explains that the reason NOG expression leads to an increased potential for breast cancer to bone metastasis is because it not only affects features inherent to aggressive cancer cells (such as the ability to establish a new tumor) but also influences properties of the bone environment (such as osteoclast degeneration of bone).

###

From the article: "Identification of NOG as a specific breast cancer bone metastasis-supporting gene" by Maria Tarragona, Milica Pavlovic, Anna Arnal-Estap, Jelena Urosevic, Mnica Morales, Marc Guiu, Evarist Planet, Eva Gonzlez-Surez, Roger R. Gomis

Link to "Paper in Press": http://www.jbc.org/content/early/2012/04/30/jbc.M112.355834.full.pdf+html

Corresponding author: Roger R. Gomis, Oncology Programme, Institute for Research in Biomedicine in Barcelona, Spain; e-mail: roger.gomis@irbbarcelona.org

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Tracking breast cancer cells on the move

UNC’s Saskia Neher selected as 2012 Pew Scholar

Newswise CHAPEL HILL, N.C. - Saskia B. Neher, PhD, assistant professor in the department of biochemistry and biophysics at the University of North Carolina School of Medicine, was one of twenty-two of Americas most promising scientists to be named Pew Scholars in the Biomedical Sciences by the Pew Charitable Trusts.

Neher is the eleventh such recipient for UNC since the program began in 1985 and she is one of 8 women among 22 awardees, overall, nationwide.

The 2012 Pew Scholars will join a select community that includes MacArthur Fellows, recipients of the Albert Lasker Medical Research Award and three Nobel Prize winners. The program encourages early-career scientists to advance research that leads to important medical breakthroughs and treatments.

Nehers research explores the molecular systems that help to activateand disablethe breakdown of fat. When we consume food rich in fat, molecules called lipases break down the fat so that it can be used as a source of fuel or be stored. In humans, defects in a lipase called LPL increase an individuals risk of cardiovascular disease. The activity of this molecule is regulated by a pair of proteins: one that activates LPL and another that switches it off when an animal fasts. Neher uncovered evidence that suggests how the activating protein functions.

Nehers work now will be to determine how the regulators of LPL interact, using sophisticated approaches in biochemistry, molecular biology and crystallography. Her research should provide insights into the regulation of an important process that could produce new targets for the treatment or prevention of cardiovascular disease.

Pew is pleased to provide this countrys most ambitious and dedicated scientists with timely funding that enables them to explore novel areas of investigation early in their careers, at what may be the most inventive and creative period in their research, said Rebecca W. Rimel, president and CEO of The Pew Charitable Trusts.

The program has invested more than $125 million to fund over 500 scholars. Recipients receive $240,000 over four years to pursue their research without restriction. Applicants are nominated by an invited institution and demonstrate both excellence and innovation in their research. This year, 179 institutions were requested to nominate a candidate and 134 eligible nominations were received.

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UNC's Saskia Neher selected as 2012 Pew Scholar

Novel biochemistry in Bovine immunodeficiency virus [erv]

Many roads lead to Rome there is no one right way to solve an evolutionary hurdle. Viruses encounter the same evolutionary problems, but have evolved lots and lots and lots of different solutions to the exact same problems. Random chance of mutations + the bumbling blindness of natural selection (good enough is selected, not BEST!) means all that bumbling mess leads to different solutions. Some might work better than others, but they all work, and thats good enough.

Its easy to comprehend an RNA virus doing something differently than a very distantly related DNA virus. But differences exist between closely related viruses as well. We all know no-new-genes-no-new-functions Michael Behe and his Creationist BFFs hate the evolutionary capacity of new-genes-new-functions HIV-1. They have to hate its cousin Bovine immunodeficiency virus too:

The bovine immunodeficiency virus Rev protein: identification of novel nuclear import pathway and nuclear export signal among retroviral Rev/Rev-like proteins

There are lots of different ways to get a protein. Retroviruses operate like a sheet cake it makes one bit mRNA that gets cuts up into lots of little mRNAs as it leaves the nucleus, which go one to be translated into all the proteins the retrovirus needs.

But then how to you get a retroviral genome into the babby viruses? The retroviral genome is a big uncut piece of mRNA. If it always gets cut up when it leaves the nucleus, how can you ever get that big uncut RNA genome into new viruses?

Lentiviruses have an answer to this dilemma Regulator of Virion Expression, Rev.

Rev escorts the mRNA out of the nucleus, so it can be chopped up in different ways to get different retroviral proteins, or, prevent the RNA from being cut entirely so full genomes can be packaged into babby viruses.

And of course, its not just about Rev getting out of the nucleus with its RNA companion. It must also be able to get itself into the nucleus. Proteins like Rev are made in the cytoplasm on ribosomes it needs to perform a few tricks to get itself into the nucleus to pick up its RNA buddy.

So Rev does two things gets into the nucleus, gets out of the nucleus with RNA. Gets into the nucleus, gets out of the nucleus with RNA. Over and over.

You would think that Rev from HIV and Rev from BIV would look and behave in the same manner. Theyre the same protein from the same family of retrovirus (lentivirus) that accomplish the same function.

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Novel biochemistry in Bovine immunodeficiency virus [erv]

The science of training and development in organizations: What really matters, what really works

Each year in the United States about $135 billion is spent in training employees but those billions do not always improve the workplace because the skills often do not transfer to the actual job.

"Learning is a way of life in organizations," says Eduardo Salas, a psychological scientist from the University of Central Florida. "Everyone gets training. But what matters? What works? What influences learning and skill acquisition?"

In a new report published in Psychological Science in the Public Interest, a journal of the Association for Psychological Science, Salas and co-authors conclude that when this money is well spent, "training and development activities allow organizations to adapt, compete, excel, innovate, produce, be safe, improve service and reach goals."

One of the most important things that "matters", the researchers found in their survey of the vast scientific literature on the science of training, is that human resource executives, chief learning officers and business leaders should view training as a whole system and not a one-time event. This means that what happens before and after the actual training are just as important as the training itself.

Training is especially effective when various jobs in the organization have been analyzed, the skill sets of its employees are understood, supervisors and leaders are all on the same page and trainees are motivated to learn. During the training, whether it is computer and technology based or in a classroom, sufficient structure and guidance should be offered to trainees while still giving them opportunities to make decisions about their learning experience. After the training, trainees should have ample time and opportunities to use what they have learned in the real world with real feedback.

The individual characteristics that trainees bring to a learning environment are especially important to consider when implementing training programs. Research shows that trainees who believe that their abilities actually influence training outcomes are more likely to persist in learning activities, even when they encounter challenges. And psychological science has also shown that trainees who are oriented toward mastery or learning may perform better when they can control how they explore and organize training material, whereas trainees who are oriented toward performance seem to do better in highly structured environments that involve successively more complex tasks.

The broader psychological science of learning can also inform effective training programs. Research shows that a gap exists between performance in training and the integration of newly learned skills on the job. But that gap can be narrowed through the application of various empirically tested insights into learning. For example, repeating tasks within increasingly complicated contexts helps to ensure that learning lasts over time. Furthermore, encountering errors during training helps to prepare trainees for real-life situations as they are required to apply concepts learned in training. Finally, watching someone else perform certain skills can also contribute to learning, a concept scientists refer to as behavioral role modeling.

Despite the wealth of practical and scientific research in this field, as Paul W Thayer, professor of psychology from North Carolina State University in Raleigh points out in his commentary accompanying the article, "There is still a tendency in business, government, and academia to adopt programs based on little more than attractiveness, modishness, or a desire to keep up with others in the field."

Salas and his colleagues have tips for policymakers, too, who may need to assess skills across an entire country or geographic region, and whose goals are more likely to include skills that are relevant to many jobs to ease employee transfers. Establishing a well-prepared labor pool can help to attract businesses, provide jobs, and increase competitiveness in a given area or industry. With this in mind, the authors emphasize that "government should not be promoting or investing in training efforts that fail to incorporate the principles of good training."

Policymakers can use the best practices of training evaluation to scrutinize funded training programs for inefficiencies and determine whether those programs still merit funding.

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The science of training and development in organizations: What really matters, what really works

Project L.E.A.N. Childhood Obesity Prevention Program Shows Excellent Results at the End of Its Second Year

Pepperidge Farm, Inc., Norwalk Hospital, Norwalk Health Department and Jefferson Elementary School Join Forces to Combat Childhood Obesity

NORWALK, Conn.--(BUSINESS WIRE)--Two hundred second and third graders at Jefferson School are ending the school year on a very healthy note. These students now have a significantly broader knowledge base about the importance of good nutrition and physical activity. Furthermore, they have made behavioral changes that will improve their long-term health. This is all due to the instruction they received from Project L.E.A.N. (Learning with Energy from Activity and Nutrition), a childhood obesity prevention program being offered at Jefferson School in Norwalk. The pilot program was started in 2010 through collaboration between Pepperidge Farm, Inc., Norwalk Hospital, Norwalk Department of Health, and Norwalks Jefferson Elementary School.

In particular, the principal at Jefferson School, John Reynolds, and the teachers deserve much of the credit for this programs success. From the very beginning, everyone including the students, teachers, parents and partners embraced the Project L.E.A.N. approach to improve the childrens health.

Project L.E.A.N. was designed to improve the overall health of children by teaching them lifelong habits of healthy eating and exercise. The program includes a breakfast boot camp, in-school nutrition classes taught by Cindy Sherlock MS, RD, CD-N, a dietician at Norwalk Hospitals Clinical Nutrition Department, and after school family events.

At the end of the second year, the program results are excellent. The students who have gone through the program have demonstrated a significant increase in their knowledge about good nutrition which has led to positive behavioral changes, says Ruthann Walsh, Director, Corporate Citizenship at Pepperidge Farm and one of the programs organizers. For example, the vast majority of the children now understand that it is unhealthy to be overweight and furthermore, they can cite specific chronic medical conditions that can arise from being overweight such as diabetes, heart disease and cancer. The children who have not gone through Project L.E.A.N. are not nearly as aware of these potential health risks. Additionally, Project L.E.A.N. students have dramatically reduced their consumption of sugar sweetened beverages, replacing them with water and milk, they have increased their consumption of fruits and vegetables and they have increased their level of physical activity. Furthermore, the BMI (Body Mass Index) profile of the Project L.E.A.N. students is better than all other classes at Jefferson.

Project L.E.A.N. stemmed from a desire to combat the national obesity crisis, starting on a local level. National and local statistics reveal a dire need for change:

Jefferson Elementary was chosen as a pilot school for the program because it is the largest elementary school in Norwalk, serves the largest minority population (83%) of elementary schools in Norwalk, and has a large population of children who receive free or reduced rate lunchesan indicator of financial need.

Pepperidge Farm is proud to be one of the founding sponsors of Project L.E.A.N. Its an innovative approach to combating childhood obesity and could not have gotten off the ground without the partnership between the hospital, school, health department and the business sector, said Walsh. In particular, the principal at Jefferson School, John Reynolds, and the teachers deserve much of the credit for this programs success. From the very beginning, everyone including the students, teachers, parents and partners embraced the Project L.E.A.N. approach to improve the childrens health.

Project L.E.A.N. will start up again in the fall at Jefferson School, but in the meantime, the students will be invited to attend three Project L.E.A.N. Summer festivities, keeping everyone in tip-top shape for the fall.

About Pepperidge Farm

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Project L.E.A.N. Childhood Obesity Prevention Program Shows Excellent Results at the End of Its Second Year

Attention Doctors: Is Personalized Healthcare the Answer to Your Practice Woes? Find Out at Upcoming Seminar

LAS VEGAS, June 12, 2012 /PRNewswire/ --While many doctors continue to struggle with stagnant or decreasing revenues, long wait times for patients and the frustration that comes with dealing with medical insurance companies, others are saying personalized healthcare has helped turned their practices around.

Find out if personalized healthcare is right for you at a unique session for medical professionals that will be held immediately following the open to the general public "Live Better, Longer Optimal Health and Wellness withHormones, Nutrition and Preventive Medicine" Seminar, Saturday, June 16, from 11-noon at Life Time Athletic 10721 W. Charleston Blvd. Summerlin, NV 89135 Third Floor Conference Room.

During the special follow-up session, Dr. Michael S. Mall, Personalized Health Care, will explain why he, and many other experts, believe personalized health care is the future of medicine in the United States.

"Personalized healthcare provides doctors with an easier business model to reach out to patients with personalized and preventative healthcare," Mall said. "In fact, studies have shown that patients receiving personalized healthcare make, on average, 65% less hospital visits than patients receiving traditional medical care."

Mall said personalized healthcare offers a number of benefits for both patients and doctors. For example, patients enjoy:

Meanwhile, physicians get steady monthly revenue that ranges from $1,500 to $2,200 per patient and that includes a 90% yearly renewal rate.

Session attendees will learn how to take advantage of the growing personalized healthcare trend to organize their practice in a way that increases sales and profits while allowing them to provide improved patient care.

They'll also learn how to increase gross sales by over $1 million in just one year; receive financial tips from a Wells Fargo banker who specializes in helping medical practices; learn how to start using age management programs to send sales soaring; and much more.

In addition, the follow-up session will include more information on hormone therapy and how it in particular and anti-aging/age management programs in general can help increase a practice's profits.

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Attention Doctors: Is Personalized Healthcare the Answer to Your Practice Woes? Find Out at Upcoming Seminar

Grey's Anatomy Star Eric Dane and Rebecca Gayheart Talk Kids—and the Show's Finale Surprise

Dane, 39, and Gayheart, 40, say Billie is finally warming up to little Georgina.

"Billie is being a great big sister now," Gayheart gushed to us at the Chrysalis Butterfly Ball in L.A.

"We've had a couple rough patches but she really adores her," she said. "She's really sweet. It's like her live baby doll."

That means Billie is getting more hands-on with mom and dad's baby duty.

"She helps change her diaper and give her food and put her bib on," Gayheart said, adding, "but sometimes she regresses and wants the pacifier for herself."

Meanwhile, Dane dished his thoughts about Grey's Anatomy's shocking season eight finale in which costar Chyler Leigh was surprisingly killed off.

"I wasn't [shocked] because I knew that Chyler wanted to spend some more time with her family," Dane said. "It's a tough schedule to keep up and she's been working on the show for five seasons. So I wasn't shocked. A little surprised but not shocked. We're going to miss her."

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Grey's Anatomy Star Eric Dane and Rebecca Gayheart Talk Kids—and the Show's Finale Surprise