Could a newly discovered viral genome change what we thought we knew about virus evolution?

Public release date: 18-Apr-2012 [ | E-mail | Share ]

Contact: Dr. Hilary Glover hilary.glover@biomedcentral.com 44-203-192-2370 BioMed Central

A study published in BioMed Central's Biology Direct journal reports the existence of a previously undetected group of viruses and, more importantly, a new type of viral genome that could have huge implications for theories of viral emergence and evolution.

Viruses are the most abundant organisms on earth, yet little is known about their evolutionary history since they have exceptionally high rates of genetic mutation which are difficult to track. Viral metagenomics, however, is becoming an increasingly useful tool with which to glimpse virus evolution, as it makes available vast amounts of new sequence data for analysis.

Kenneth M Stedman's team from Portland State University in Oregon, USA, used a metagenomics approach to investigate virus diversity in Boiling Springs Lake in Lassen Volcanic National Park, USA, an acidic, high temperature lake (ranging from 52-95C, with a pH of ~2.5) that sustains a purely microbial ecosystem.

Astonishingly, they found a unique viral genome that has never before been reported - a circular, single-stranded DNA virus encoding a major capsid protein seen previously only in RNA viruses. This unusual genome provides proof that integration of an RNA virus into a DNA virus may have occurred between two unrelated virus groups at some point in evolution - something that has not been observed before. Moreover, this suggests that entirely new virus types may emerge via recombination of functional and structural modules between vastly different viruses, using mechanisms that are as-yet unknown.

The team observed that the Boiling Springs Lake RNA-DNA hybrid virus (BSL RDHV) genome is circular, but its size is roughly double that of typical circoviruses, with the ORFs arranged in an uncommon orientation. They compared the BSL RDHV genome to other metagenomic DNA sequences from the Global Ocean Survey, and found strong evidence to conclude that previously undetected BSL RDHV-like viruses could be widespread in the marine environment and are likely to be found in other environments as well.

No mechanism has been proposed to account for the inferred instances of interviral RNA-DNA recombination, but the team speculate that a DNA circovirus-like progenitor may have acquired a capsid protein gene from a ssRNA virus via reverse transcription and recombination.

Lead author Kenneth M Stedman said, "As more viral metagenomic data are generated and analyzed, additional evidence of recombination between RNA and DNA virus groups will likely be discovered. The discovery that novel virus groups can emerge via recombination between highly disparate virus types will have broad implications for the early evolution of viruses and extends the modular theory of virus evolution to encompass a much broader range of possibilities than previously thought."

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Could a newly discovered viral genome change what we thought we knew about virus evolution?

Experimental Biology 2012: Conference Blogging Basics

Sci is flying out tomorrow to take part in (and blog about) the Experimental Biology meeting in San Diego. I will be blogging on behalf of the American Society for Pharmacology and Experimental Therapeutics, so itll be all things pharmacology from here on out! Make sure to check out the blog and follow along on Twitter! See you in San Diego!

But perhaps I have emailed you, and asked to blog your poster, and perhaps you are considering emailing me about your latest and greatest workand you pause. What IS this conference blogging, exactly? What is it for?

Well, look no further. Because this post (a re-post from my previous blogging of the Society for Neuroscience Meeting) is all about explaining what Im planning for the conference, how Im going to go about it, and what you can look forward to as a scientist when I blog your poster or talk. And because the more you know, the better prepared we will all be!

(source)

I covered much of this information in a guest post over at the Science of Blogging, where I talked about tips for blogging a conference. But that post is from a bloggers point of view, whereas this one will be from the perspective of you, the scientist.

So this is how it goes:

1. Over the next few days, I will either contact you, or you can contact me (scicurious at gmail) with your poster/presentation details. I will set up a time to come by your poster, and possibly also to meet with you for 30 minutes before or after your presentation.

2. If we meet up, I would like to hear from you about your work in detail. I will be reading the abstract that you submitted ahead of time, but If you could bring a copy of your poster or presentation (or send it ahead of time!) that would be wonderful! I will NOT use any of the graphs, tables, or images that you send in any post I may write up. What I will do is use your poster to give my my writing context and help me to remember and understand what weve talked about and the significance of your findings.

2a. If you are a student presenter (or heck, a postdoc!), you may want to bring your advisor along while we talk, if you are worried. Additionally, if your advisor requires credentials, let me know and I will provide them.

3. Once Im done grilling you (gently!) about your work, Ill head back, and start writing! I will try to get the post done before the next day.

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Experimental Biology 2012: Conference Blogging Basics

ASU Professor of Chemistry Named 2012 Professor of the Year

Newswise The Arizona State University Parents Association honored Ian Gould, professor of chemistry and biochemistry in the College of Liberal Arts and Sciences (CLAS), as the 2012 Professor of the Year for his lifelong commitment to science and his ability to inspire students to become innovative in often-difficult chemistry classes.

With his internationally recognized career and extensive ongoing research, Gould provides tremendous vision and direction to ASU students. Through passionate and inspirational classroom instruction, he demonstrates a powerful devotion to undergraduate students and inspires each to excel both in and out of the classroom.

The students are number one. Ive learned something from every one of them, said Gould, receiving the honor before more than 200 ASU faculty, students, staff, administrators, parents, friends and other nominees at the Faculty Excellence Awards. I didnt prepare to win. There were a lot of nominees, and statistically it seemed improbable.

Parents Association Special Recognition awards also were presented to Lenore Dai, professor of chemical engineering in the Ira A. Fulton Schools of Engineering, and Danwen Jiang, professor of music in the Herberger Institute of Design and the Arts. Information and a video about the 29 nominees can be found at asu.edu/pty.

Originally from the United Kingdom, Gould has received honors for his distinguished work, including the Organic Chemistry Prize in 1977 from Manchester University and the Gramatacakis Neumann Award in 1985 from the European Photochemical Association. Gould also won a CLAS Distinguished Teaching Award in 2002 and appointment to ASUs Presidents Professors in 2005.

After a substantial research career at Eastman Kodak, Gould joined ASU in 1998 offering students a strong industry perspective of science, resulting in his on-site and online classes filling quickly. While teaching, Gould takes time from his personal life to ensure he allows for one-on-one meetings with any student that requires his assistance. Gould, who received his doctorate in 1980 from the University of Manchester in the United Kingdom, was promoted to full professor at ASU in 2004.

The ASU Parents Association awarded the first Professor of the Year in 1994. Thanks to the continued generosity of ASU families and the participation of ASU students, faculty and staff, the ASU Parents Association bestows this prestigious honor annually. Four undergraduate students and three faculty colleagues contributed letters in support of Goulds nomination. These letters were considered by the committee of parents, other Professors of the Year and scholarship students in recognizing Gould.

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ASU Professor of Chemistry Named 2012 Professor of the Year

Nature photographer inspires Breck Library

"Not all nature photography is wonderful and exciting. Im just now getting over my second case of poison ivy this spring alone, joked Bruce Flaig during his talk at the Breckenridge Public Library Tuesday afternoon.

Flaig, a Minnesota native, gave a slide show presentation of his photography and a question- and-answer session as part of the Lake Agassiz Regional Librarys The Beat Goes On! Sugarbeet Series. Hes been a professional photographer for two decades, but in earlier years he worked as an analytical chemist and biochemistry lab technician. He credits his attention to detail and patience with photography to his scientific background.

Birds are his favorite animals to photograph, but his work is peppered with colorful landscape images as well as macro shots of insects and wildflowers. He lives on 120 acres near Fertile, Minn., and is able to view a number of species from his property, which includes native prairie grasslands, oak trees and a lake.

Flaig said the best time to shoot just about anything outdoors is early morning and late afternoon.

Generally you want your shadow pointing at what youre shooting at, he explained. You can have the sun pointing in your face and use it effectively, but generally you want it behind you.

He said when the sun is high in the sky is the worst time to shoot and thats when nature photographers go in to take a nap.

Flaig shared many stories about his experiences seeking out the perfect shot, including one time when he spent 45 minutes walking around a tree to find the perfect angle.

It was a great tree, I just couldn't find the angle, Flaig said.

He uses a Fresnel lens when shooting birds, which amplifies the available light. He also uses a flash, which enhances the feather detail of the avians.

Flaig said its important to be patient when photographing wildlife and to get creative. He said a car can be used as a blind to shoot from. Most birds are used to seeing cars and arent bothered by them.

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Nature photographer inspires Breck Library

Science finds that alcohol boosts creative problem solving (video)

According to the Federation Association of Brain and Behavioral Sciences, it is all about the distracting elements that bring the big ideasAnd whats better known for providing distraction, than alcohol?

The study reports that by reducing a persons focus, a persons ability to creatively problem solve is enhanced.

The study concludes, that its all about the reduced role of the working memory part of the brain. This is what gives us the capacity to focus, make decisions, and be logical. When this is not engaged, the brain is simply streaming consciousness and is distracted.

The same occurs by sleeping, taking a hot shower, or getting older.

This distraction gives the brain the ability to be innovative and creative problem solve by associating remote ideas together.

This creative problem solving, essentially entails thinking outside the box.

If you have ever experienced a sudden answer popping into your head, from what seems out of nowhere-you have experienced creative problem solving.

CTV Reporter Elizabeth Drolet speaks with a CSU Cognitive Psychology Grad Student, as well as, hears students reactions about the potential creative outlet they are tapping into when moderate drinking occurs.

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Science finds that alcohol boosts creative problem solving (video)

Lead Dust Exposure Linked to Violence

A new study reveals that childhood exposure to lead dust is linked to violence. The research pointed out issues with exposure to leaded gasoline and acts of violence up to 20 years after the exposure.

According to the new findings, which are published in the journal Environment International and written by toxicologist Howard W. Mielke, childhood exposure to lead dust is associated with long-lasting physical and behavioral effects, said Science Daily. Lead dust, says Mielke, has been connected to aggravated assaults two decades after exposure. Mielke, a research professor at the Department of Pharmacology at the Tulane University School of Medicine, collaborated with Sammy Zahran, a demographer at the Center for Disaster and Risk Analysis at Colorado State University.

According to the researchers, vehicles that used leaded gasolinebest known for its air contaminationhave led to increases in aggravated assaults in urban areas, said Science Daily.

The study reviewed lead releases in Atlanta, Georgia; Chicago, Illinois; Indianapolis, Indiana; Minneapolis, Minnesota; New Orleans, Louisiana; and San Diego, California from 1950 to 1985, said Science Daily. Increases in airborne lead dust exposure seen during this time frame were attributed to leaded gasoline, wrote Science Daily; correlative spikes were seen in aggravated assault rates about 20 years later, after exposed children were grown.

After controlling for other potential causes, including community and household income, education, policing efforts, and incarceration rates, Mielke and Zahran revealed that for every 1% increase in tonnage of environmental lead released 22 years prior, the present aggravated assault rate increased by 0.46%, said Science Daily.

Children are extremely sensitive to lead dust, and lead exposure has latent neuroanatomical effects that severely impact future societal behavior and welfare, says Mielke. Up to 90% of the variation in aggravated assault across the cities is explained by the amount of lead dust released 22 years earlier, Mielke added, said Science Daily. Tons of lead dust were released in the years from 1950 to 1985 in urban areas by vehicles that ran on gasoline, said Science Daily. Also, the improper handling of lead-based paint contributed to lead contamination.

As weve long written, exposure to lead in children and unborn children can cause brain and nervous system damage, behavioral and learning problems, slowed growth, hearing problems, headaches, mental and physical retardation, and behavioral and other health problems. Lead is also known to cause cancer and reproductive harm and, in adults, can damage the nervous system. The developing brain is of particular concern over negative influences known to have long-lasting effects that can continue well into puberty and beyond. Once poisoned, no organ system is immune.

Children with lead poisoning may experience irritability, sleeplessness or excess lethargy, poor appetite, headaches, abdominal pain with or without vomitinggenerally without diarrheaand constipation, and changes in activity level. A child with lead toxicity can be iron deficient and pale because of anemia and can be either hyperactive or lethargic. In adults there may be motor problems and an increase in depressive disorders, aggressive behavior, and other maladaptive affective disorders, as well as problems with sexual performance, impotence and infertility, and increased fecal wastage and sleep disorders. Lead poisoning can also result in oversleeping or difficulty falling asleep.

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Lead Dust Exposure Linked to Violence

Getting Out the Vote

STANFORD GRADUATE SCHOOL OF BUSINESS Researchers applying psychology to the realm of politics are finding that giving voters a few strategic nudges can push far more people in the direction of polls on election day.

Old standard get-out-the-vote phone call scripts made by volunteers simply asked people to participate in the election and reminded callers that voting was important. But now, using insights on how people make decisions, political parties and other organizations are finding that subtle changes in language even from a verb to a noun can make a substantial difference in how many people cast ballots.

Studies presented at Stanford on March 30 showed that more voters are motivated to go to the booths when they are told turnout will be high and when they are provoked to discuss plans for getting there. Moreover, they also are more likely to vote when they are threatened with personal accountability and when they are encouraged to see voting as an intrinsic part of their identity, rather than just something they do.

Since the 2006 election, in fact, organizations have doubled or tripled the efficiency of their get-out-the-vote budgets by including such messages, according to Todd Rogers, a Harvard professor and former founding executive director of the political research organization Analyst Institute. Rogers presented the work to nonprofit and corporate leaders assembled for The Science of Getting People to Do Good briefing, sponsored by the Center for Social Innovation at the Graduate School of Business.

Typical voter campaign telephone scripts just encouraging people to vote, Rogers said, end up being a total waste of time and have no impact on voting behavior. What works in such calls, instead, is getting people to form a voting plan.

In a controlled study of voter mobilization phone calls in the 2008 Pennsylvania presidential primary, which pitted Hillary Clinton against Barack Obama, researchers discovered that differences in scripts affected turnout. Scripts that guided people to think through the logistical details of their plans for voting such as when they intended to head to the polls, how they would get there, and what they would be doing beforehand were more than twice as effective as the standard scripts that simply asked people if they intended to vote.

This shows that cognitive planning and mechanical logistics, not just motivation, are part of the voting decision, Rogers noted. But the plan-making only affected single-voter households. Voters who live alone are less likely to have a plan than people who live in groups or families, where discussing the next days events are a natural part of life. So the intervention has much more impact on those who live alone, Rogers said.

Personal accountability matters, too. In a study of the 2010 general election, researchers sent one group of potential voters a psychologically sophisticated mailing encouraging them to vote. Another group received the same mailing, plus in the top right corner a box saying: We may call you after the election to talk about your voting experience. Adding that box increased the effectiveness of the mailing in terms of the voting it stimulated by almost half. The effect was especially strong among those who were the most civically engaged, based on their answers to a post-election survey of civic questions like: How many amendments are there in the Bill of Rights?

Join the Trend or Buck the Trend?

A common tactic used by press, politicians, and pundits to get people to vote has simply been to lament low voter turnout. But, Rogers has conducted research showing that such messages actually demotivate voting. This is because people are fundamentally social beings, and so the behavior of others influences their behavior, he explained.

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Getting Out the Vote

Leading Provider of Doctor-Formulated Nutritional Supplements Gets America Moving in a Healthy Direction with the …

POTOMAC, Md., April 18, 2012 /PRNewswire/ --Healthy Directions, a leading health publisher and provider of proprietary, doctor-formulated nutritional supplements, skincare and weight-loss products, today announced the launch of its newly designed health and wellness website http://www.HealthyDirections.com.

With a 20-year track record of highly efficacious doctor-developed formulations, Healthy Directions is known for incomparable safety, quality, and customer service. Its new website has been redesigned to provide consumers with targeted, doctor-guided information on how to prevent, treat and/or cope with common health conditions and ailments that affect a significant number of Americans, including heart disease, diabetes, digestion issues, arthritis, hormonal issues, and aging. In addition to featuring hundreds of pages of expert content, the new website will include an online store, offering an array of supplements, skincare and other health and wellness products.

The website also offers exclusive access to the Healthy Directions doctors -- leaders in the field of alternative and integrative healthcare practices who have earned reputations as the world's leading authorities in natural healing. Together they share a common goal: to help people live longer, healthier, and more vibrant lives. The site outlines each doctor's unique approach to wellness and area of specialty, including specific guidance and recommendations that visitors can begin using right away to improve their health.

The Healthy Directions doctors include:

"It is our mission to get America moving in a healthy direction and we have re-launched HealthyDirections.com to provide consumers with easy access to our extensive collection of health and wellness guidance, advice and resources that were previously only available via subscription newsletters," says Healthy Directions Executive Vice President Connie Hallquist.

In addition to its rich content, HealthyDirections.com offers consumers a vast array of alternative supplements to support specific health needs including bone health, joint health, brain and memory, cardiovascular health, immunity, men's and women's health, weight loss, sleep, and vision. All of Healthy Directions products are proudly made in the USA or Canada from the finest ingredients available worldwide. Adhering to stringent quality standards and a Triple Testing Philosophy that exceeds industry Good Manufacturing Practice (GMP) and FDA requirements, Healthy Directions delivers safe, superior products backed by a 100% satisfaction guarantee.

"Whether it's through our rich content or doctor-formulated quality nutritional supplements, Healthy Directions continues to stay true to its unwavering commitment to safety, superior product quality, and life-changing expert guidance," Hallquist adds.

About Healthy Directions

Healthy Directions, LLC, a leading health publisher and provider of doctor-formulated nutritional supplements, skincare and diet products, is dedicated to helping people lead healthier, happier lives by providing expert guidance and advanced nutritional supplements from America's leading doctors of integrative medicine. Offering consumers solutions to help them achieve vibrant health throughout their lives, Healthy Directions works with some of the nation's most knowledgeable and highly respected integrative and alternative doctors, including Dr. Julian Whitaker, Dr. David Williams, Dr. Stephen Sinatra, Dr. Susan Lark and Dr. Aaron Tabor. For more information about Healthy Directions, please visit http://www.healthydirections.com.

Media Contact: Lauren Aboulessan Krupp Kommunications (212) 886-6710 LAboulessan@kruppnyc.com

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Leading Provider of Doctor-Formulated Nutritional Supplements Gets America Moving in a Healthy Direction with the ...

The Anatomy of Sovereign Default

The three primary factors that determine the interest rate level a nation must pay to service its debt in the long term are; the currency, inflation and credit risks of holding the sovereign debt. All three of those factors are very closely interrelated. Even though the central bank can exercise tremendous influence in the short run, the free market ultimately decides whether or not the nation has the ability to adequately finance its obligations and how high interest rates will go. An extremely high debt to GDP level, which elevates the country's credit risk, inevitably leads to massive money printing by the central bank. That directly causes the nation's currency to fall while it also increases the rate of inflation.

It is true that a country never has to pay back all of its outstanding debt. However, it is imperative that investors in the nation's sovereign debt always maintain the confidence that it has the ability to do so. History has proven that once the debt to GDP ratio reaches circa 100%, economic growth seizes to a halt. The problem being that the debt continues to accumulate without a commensurate increase in the tax base. Once the tax base can no longer adequately support the debt, interest rates rise sharply.

Europe's southern periphery, along with Ireland, has hit the interest rate wall. International investors have abandoned their faith in the bond market and these countries have now been placed on the life support of the European Central Bank. Without continuous intervention of the ECB into the bond market yields will inexorably rise.

The U.S. faces a similar fate in the very near future. Our debt is a staggering 700% of income. And our annual deficit is over 50% of Federal revenue. Just imagine if your annual salary was 100k and you owed the bank a whopping 700k. Then go tell your banker that you are adding 50k each year-half of your entire salary--to your accumulated level of debt. After your bankers picked themselves off the floor, they would summarily cut up your credit cards and remove any and all existing lines of future credit. Our gross debt is $15.6 trillion and that is supported by just $2.3 trillion of revenue. And we are adding well over a trillion dollars each year to the gross debt. Our international creditors will soon have no choice but to cut up our credit cards and send interest rates skyrocketing higher.

When bond yields began to soar towards dangerous levels in Europe back in late 2011 and early 2012, the ECB made available over a trillion Euros in low-interest loans to bailout insolvent banks and countries. Banks used the money to plug capital holes in their balance sheets and to buy newly issued debt of the EU nations. That caused Ten-year yields in Spain and Italy to quickly retreat back under 5% from their previous level of around 7% just a few months prior. But now that there isn't any new money being printed on the part of the ECB and yields are quickly headed back towards 6% in both countries. There just isn't enough private sector interest in buying insolvent European debt at the current low level of interest offered.

The sad truth is that Europe, Japan and the U.S. have such an onerous amount of debt outstanding that the hope of continued solvency rests completely on the perpetual condition of interest rates that are kept ridiculously low. It isn't so much a mystery as to why the Fed, ECB and BOJ are working overtime to keep interest rates from rising. If rates were allowed to rise to a level that could bring in the support of the free market, the vastly increased borrowing costs would cause the economy to falter and deficits to skyrocket. This would eventually lead to an explicit default on the debt.

But the key point here is that continuous and massive money printing by any central bank eventually causes hyperinflation, which mandates yields to rise much higher anyway. It is at that point where the country enters into an inflationary death spiral. The more money they print, the higher rates go to compensate for the runaway inflation. The higher rates go the worse economic growth and the debt to GDP ratio becomes. That puts further pressure on rates to rise and the central bank to then increase the amount of debt monetization...and so the deadly cycle repeats and intensifies.

The bottom line is that Europe, Japan and the U.S. will eventually undergo a massive debt restructuring the likes of which history has never before witnessed. Such a default will either take the form of outright principal reduction or intractable inflation. History illustrates that ownership of gold will provide a safe harbor for your wealth when paper currencies are being inflated into oblivion.

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The Anatomy of Sovereign Default

Anatomy of An Offense

Tuesday, April 17th, 2012 at 12:45 pm | 3 responses

A scattering of thoughts on Princeton, Pete Carril and basketballs most deliberate system.

by Nick Rotunno

As basketball fans across America recovered from a wild, bracket-busting weekend of March Madness, the Princeton University mens team quietly wrapped up the 11-12 season on March 19, falling to the Pitt Panthers in the quarterfinals of the College Basketball Invitational (CBI). Almost no one noticed, because the CBI is an unceremonious little tournament for mostly average teams, and the national media had bigger things to write about.

The game was played in Pittsburgh on the Panthers home floor, and Princeton was wholly outmatched. By halftime Pitt had built a 24-point lead, and the Panthersout-shooting and out-rebounding the smaller Princeton squadcruised to an 82-61 victory. The Tigers hung around in the early going, but Pitts Big East bruisers were too much to handle.

According to the Princeton athletics website, the only good news for the Tigers concerned senior guard Douglas Davis, whose game-high 20 points moved him into second place on Princetons all-time scoring list (1,550 career points). An impressive achievement, to be sure, but Davis is still a long way from the incomparable Bill Bradley, the Tigers all-time scoring champion, who tallied a staggering 2,504 points in just three seasons of college ball, before the era of the three-point line. Bradleys total is all but unreachable, though Davis gave it a solid try.

Princeton finished a respectable 20-12 this season (11-4 in the Ivy League). It was an up-and-down year for head coach Mitch Henderson and the Tigers: Princeton kicked off the schedule with a head-scratching home loss to Wagner, nearly beat North Carolina State in Raleigh four days later, won a few, lost a few, then defeated Rutgers 59-57 on December 7. In the conference season, Princeton split with archrival Harvard, but the Crimson played well all winter, won the Ivy League and earned a berth in the NCAA Tournament (they didnt make it very far). The boys from New Jersey had to settle for the CBIPrinceton beat Evansville in the first round before getting hammered by Pitt.

All told, the Tigers 11-12 campaign was a moderate success.

So why spill so much ink on a mediocre team, after an unspectacular season? A fair question. To be honest, Ive never been to Princeton, NJ, and Ive never watched the Tigers play live. Princetons favorite son, the aforementioned Bill Bradleyone of the greatest college ballplayers of all time and a former US Senatorplayed his last game for the Black-and-Orange two decades before I was born. Aside from my natural love of the underdog, that very American tendency to root for the gutsy overachiever (and my idolization of John McPhee, Pulitzer Prize-winning author and teacher of nonfiction writing at Princeton), I have no real connection to the program.

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Anatomy of An Offense

Anatomy of a plague

Global killer ... scientists have pinpointed the origin of the AIDS virus from chimp to human in Cameroon. Photo: Reuters

Following a trail of death, Craig Timberg and Daniel Halperin tell the grim story of the birth and spread of AIDS.

WE are unlikely to ever know all the details of the birth of the AIDS epidemic. But a series of recent genetic discoveries have shed new light on it, starting with the moment when a connection from chimp to human changed the course of history.

We now know where the epidemic began: A small patch of dense forest in south-eastern Cameroon. We know when: Within a couple of decades on either side of 1900. We have a good idea of how: A hunter caught an infected chimpanzee for food, allowing the virus to pass from the chimp's blood into the hunter's body, probably through a cut during butchering.

As to the why, here is where the story gets even more fascinating. We typically think of diseases in terms of how they threaten us personally. But they have their own stories. Diseases are born. They grow. They falter and sometimes they die. In every case, these changes happen for reasons.

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For decades, nobody knew the reasons behind the birth of the AIDS epidemic. But it is now clear that the epidemic's birth and crucial early growth happened during Africa's colonial era, amid massive intrusion of new people and technology into a land where ancient ways still prevailed. European powers, engaged in a feverish race for wealth and glory, blazed routes up muddy rivers and into dense forests that had been travelled only sporadically by humans before.

The most disruptive of these intruders were thousands of African porters. Forced into service by European colonial powers, they cut paths through the exact area that researchers have now identified as the birthplace of the AIDS epidemic. It was here, in a single moment of transmission from chimp to human, that a strain of virus called HIV-1 group M first appeared.

In the century since, it has been responsible for 99 per cent of all of the world's deaths from AIDS not just in Africa but in Moscow, Bangkok, Rio de Janeiro, San Francisco, New York and Washington. All that began when the West forced its will on an unfamiliar land, causing the essential ingredients of the AIDS epidemic to combine.

It was here, by accident but with motives by no means pure, that the world built a tinderbox and tossed in a spark.

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Anatomy of a plague

Anatomy students at Edward Via honor those who donated bodies to science

Students in the anatomy lab at Edward Via College of Osteopathic Medicine school of medicine. Chuck Frost, Bralin Bean, Jenna Bates, Nate Benitez, Adam Boiter, Chris Bazemore, and Nate Moore.

The anatomy lab at Spartanburg's new medical school can accommodate 193 bodies, 165 of them alive.

The 28 remaining are human cadavers, subjects of intense scrutiny for the first-year students at the Edward Via College of Osteopathic Medicine.

"Probably the most difficult thing an American medical student has to do is understand human anatomy," said Dr. Lance Paulman, a professor of anatomy at VCOM. "They take the body apart so they can learn to put it back together."

The students have worked with the same bodies since September, when the school opened, and now they're planning a memorial service on Friday in Columbia to honor the deceased.

The University of South Carolina runs the Gift of Bodies program, which allows people to donate their bodies to science after they die. Their gift provides bodies for the USC's medical school and VCOM. The service is a chance for students to honor that gift.

"They get to explain to the families (of the deceased) how beneficial their loved one's gift has been," Paulman said.

The students only learn the age, cause of death and primary occupation of the dead person they are assigned. But they learn much more about the body.

They make incisions and remove the skin. They look at the musculoskeletal system, the placement of the body's organs, and the interconnectedness of all of its systems.

"Until you go in and you see it and you look at those relationships, that's when it really hits home," said Randy Baxley, 36, a VCOM student. "You don't realize who's whose neighbor."

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Anatomy students at Edward Via honor those who donated bodies to science

Doctor’s role is key to cancer fight

DURHAM -- Dr. Gary Lyman was drawn into cancer research by the allure of finding a cure for a killer disease.

But he has found acclaim in a less splashy, yet equally vital arena making sure the tools used to treat cancer are put to their best use.

The Duke doctor and researcher has played a key role in establishing guidelines for cancer treatments, both as an adviser to the U.S. Food and Drug Administration and a leader in the countrys major oncology association.

He co-chaired a panel that earlier this month found that obese breast cancer patients are often not given full doses of cancer drugs, which likely contributes to their higher death rates. The researchers from the American Society of Clinical Oncology recommended that all patients receive doses based on their weight and height, a practice many doctors have shied away from for fear of serious side effects from large doses of toxic drugs.

The change will impact an oncologists daily practice and could save thousands of lives a year. Its a good example of Lymans focus on research that can be put into practice quickly, says Dr. Jeffrey Crawford, chief of the division of medical oncology at Duke Medicine.

A lot of the breakthroughs that we see come from clinical trials and we think weve made advances, but those advances dont really happen until they get translated into the community, Crawford said. Hes really trying to do work that improves the care of patients right away.

Earlier this year, the FDA panel Lyman serves on made a controversial decision not to approve the drug Avastin for use in breast cancer patients because of concerns about the drugs effectiveness and side effects. He has also done research on minimizing blood clots during cancer treatment, a problem so common that it was largely dismissed as inevitable.

Lymans research fits in well with a current emphasis on practicality when it comes to cancer treatments, says Dr. Howard McLeod, an expert in analyzing cancer treatments at UNC-Chapel Hill. As hopes for a single magic bullet cure have faded, maximizing the effectiveness of existing treatments has become a major research focus.

Were at the point where we have a lot of patients and we dont know if theyre being best served, said McLeod, director of the UNC Institute for Pharmacogenomics and Individualized Therapy. Lyman has been one of the first to really grab onto this idea that weve got to take the complex science and make it practical.

Cancer hits home

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Doctor’s role is key to cancer fight

New method may help detect marker for Alzheimer's disease earlier

Public release date: 15-Apr-2012 [ | E-mail | Share ]

Contact: Rachel Seroka rseroka@aan.com 651-695-2738 American Academy of Neurology

NEW ORLEANS Use of a new drug to detect the beta-amyloid plaques in the brain that are hallmark signs of Alzheimer's disease may help doctors diagnose the disease earlier, according to research that will be presented as part of the Emerging Science program (formerly known as Late-Breaking Science) at the American Academy of Neurology's 64th Annual Meeting in New Orleans April 21 to April 28, 2012.

Currently, Alzheimer's disease can only be definitively confirmed through the detection of amyloid plaques and/or tangles in the brain during autopsy after death or with a brain tissue biopsy. The new method uses the drug florbetaben as a tracer during a PET scan of the brain to visualize amyloid plaques during life.

In order to prove that the florbetaben PET scan detects beta-amyloid in the brain, the global phase III study directly compared brain regions in the PET scan to respective brain regions after death during autopsy.

For the study, more than 200 participants nearing death (including both participants with suspected Alzheimer's disease and those without known dementia) and who were willing to donate their brain underwent MRI and florbetaben PET scan. The amount of plaque found in the 31 participants who reached autopsy was then compared to the results of the scans. A total of 186 brain regions from these donors were analyzed along with 60 brain regions from healthy volunteers. Based on these 246 brain regions the study found florbetaben to detect beta-amyloid with a sensitivity of 77 percent and a specificity of 94 percent.

Comparison of the visual assessment method proposed for florbetaben for clinical practice with the post mortem diagnosis revealed a sensitivity of 100 percent and a specificity of 92 percent. Sensitivity is the percentage of actual positives that are correctly identified as positive, and specificity is the percentage of negatives that are correctly identified.

"These results confirm that florbetaben is able to detect beta-amyloid plaques in the brain during life with great accuracy and is a suitable biomarker," said study author Marwan Sabbagh, MD, director of Banner Sun Health Research Institute in Sun City, Ariz., and a Fellow of the American Academy of Neurology. "This is an easy, non-invasive way to assist an Alzheimer's diagnosis at an early stage. Also exciting is the possibility of using florbetaben as tool in future therapeutic clinical research studies where therapy goals focus on reducing levels of beta-amyloid in the brain."

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The study was supported by Bayer Healthcare Berlin.

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New method may help detect marker for Alzheimer's disease earlier

Harvard Medical School Adviser: Fix underlying cause of Baker's cyst

QUESTION: I have a Baker's cyst in my right knee. I've had it drained twice, but it keeps coming back. Are there any other treatments? Is there an operation that can fix it once and for all?

ANSWER: Your situation is fairly common. A Baker's cyst (also called a popliteal cyst) is a fluid-filled sac that can develop in the popliteal space, the hollow at the back of the knee joint.

Baker's cysts are named for William Morrant Baker, a 19th-Century surgeon who first described the condition. The cyst is filled with synovial fluid, which lubricates the knee joint. Synovial fluid reduces friction between the various parts of all your joints, including your knee, which needs lubrication to flex and extend smoothly.

Although there are several ways to treat a Baker's cyst, surgery is an uncommon choice. But whatever the treatment, the cyst will often recur if the underlying cause hasn't been corrected.

A Baker's cyst can be caused by an injury to the knee, such as a tear in a meniscus. Damage to the cartilage from conditions such as rheumatoid arthritis or osteoarthritis can lead to Baker's cysts. These conditions may cause the synovial cells lining the knee joint to produce excess fluid. If the fluid bulges into the popliteal space, a cyst can develop. The excess fluid could cause the whole knee to become swollen, too.

A Baker's cyst is often found during a physical exam or an ultrasound performed for other reasons. It may cause no symptoms at all. But it can cause pain, swelling and joint stiffness. Sometimes the bulge is so large that it's hard to fully bend or straighten the leg.

Baker's cysts aren't dangerous, and they may go away on their own. But, occasionally, they burst. If that happens, synovial fluid can leak into your calf below, causing pain and swelling.

These symptoms are similar to the symptoms associated with having a blood clot in your calf, deep vein thrombosis (DVT). DVT is a serious condition that requires immediate treatment. That's why it's important to find the source of the problem right away.

If your Baker's cyst causes discomfort or interferes with your daily activities, there are several things you can do. To bring down swelling, apply a cold pack to the area or use a compression wrap. To reduce inflammation, take an over-the-counter nonsteroidal anti-inflammatory drug such as ibuprofen (Motrin or Advil).

Because stress on the knee joint can increase inflammation, rest your leg and keep it elevated whenever you can. When you're up and about, use a cane or crutch. Sometimes, as in your case, a Baker's cyst needs to be drained. Your doctor may want to inject cortisone into your knee joint to quell inflammation.

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Harvard Medical School Adviser: Fix underlying cause of Baker's cyst

04/16/2012 10:14 TURKEY Bartholomew I: The Resurrection of Christ is the only ark of salvation for a humanity in crisis

04/16/2012 10:14 TURKEY Bartholomew I: The Resurrection of Christ is the only ark of salvation for a humanity in crisis by NAT da Polis In his Easter message, the Ecumenical Patriarch of Constantinople denounces the reckless search for material goods and material well-being, which hides fear of death, killing others. The real "fountain of immortality" already exists and is the resurrection of Jesus Christ. Christians follow the risen Christ and do his work in charity.

Istanbul (AsiaNews) - With a thought to the crisis that is afflicting the modern world, the Ecumenical Patriarch of Constantinople, Bartholomew I celebrated the Easter holidays of the Orthodox Christian world, by sending a message that emphasizes the importance of the resurrection of our Lord as only response of salvation for the world. This world, for Bartholomew, believes that through economic globalization "it has gained eternity'. In fact, globalization is based on a reckless material well-being that denigrates values which attempt to preserve the dignity of 'human existence.

His message emphasized that there is no miracle recipe for eternal life on this earth beyond the saving message of the resurrection of Christ. The mythological search for '"fountain of eternal life" is of no use, said Bartholomew, because "'immortality exists in Christ and is offered to all through Him."

"If the resurrection of Christ only involved Him, it would have no meaning for us," Bartholomew begun. "But Christ is not risen alone. With Him the whole human race is risen.... The message is joyous for all, because the Resurrection of Christ cancels the power of death. Those who believe in Him, confess the resurrection of dead and so are baptized into his death, resurrected together with Him and live to eternal life. "

"The world is far from Christ - he continued- trying to accumulate material goods in which it places all of life's hope. Man inconsiderately hopes that through wealth he will avoid death. And the man who errs in accumulating wealth, as if it could lengthen his life, spreads death to others. He rips their economic strength of survival and often violently interrupts the thread of their lives, hoping that it will save his life".

"You do not need - added the Ecumenical Patriarch - to destroy peoples to allow other peoples survive. Nor is there any need to destroy defenseless human beings to allow more prosperous fellow human beings live. Christ offers life on earth and the heavenly life to all. He has risen for those wishing to follow the path of the resurrection. In contrast, those who directly or indirectly spread death, believing it to extend or facilitate their lives, condemn themselves to eternal death. "

"Our Risen Lord, Jesus Christ - Bartholomew underscored - came into the world so that all men may have life and 'have it abundantly. It would be a great mistake to believe that the welfare of the human race can only be decided through infighting. We follow, brothers and beloved children in the Lord, the Risen Christ, in all his works. Let us help those who live without means of subsistence, to keep them alive."

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04/16/2012 10:14 TURKEY Bartholomew I: The Resurrection of Christ is the only ark of salvation for a humanity in crisis

Other primates share human taste for plant oestrogens

HUMANS aren't the only primate to risk the reproductive repercussions of a diet rich in oestrogen-like compounds. Gorillas and colobus monkeys both eat large quantities of plants containing the chemicals, which can disrupt reproduction but have been shown to protect against some cancers.

Phyto-oestrogens are plant chemicals that function like the female sex hormone. In foods like soy and red clover they may protect us from oestrogen-dependent cancers - a group that includes breast and colorectal cancers.

The sex hormone mimics may have a downside, though, says Katharine Milton of the University of California, Berkeley. "Oestrogens are potent chemicals; if you're taking them in excessive amounts, this can interfere with your reproductive physiology."

The potential health effects of phyto-oestrogens are often studied, but no one has looked at whether humans are the only primates with a taste for plants containing the chemicals, says Michael Wasserman of McGill University in Montreal, Canada. If other primates eat them, it might suggest that we have evolved to cope with them in small doses.

Wasserman, Milton and colleagues studied the diets of mountain gorillas (Gorilla beringei) and red colobus monkeys (Procolobus rufomitratus) in a national park in Uganda. They found that 10.6 per cent of plants in the colobus diet and 8.8 per cent of those in the gorilla diet contained phyto-oestrogens (American Journal of Physical Anthropology, DOI: 10.1002/ajpa.22045).

Interest in how primates respond to oestrogen-disruptors has been sparked by the rising levels of synthetic oestrogenic chemicals in our environment, such as bisphenol A - although Wasserman cautions that these synthetic forms might act differently from the natural versions.

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Other primates share human taste for plant oestrogens

Honey's Effects On Human Evolution Excite Unlv Anthropologist

Posted: Apr. 16, 2012 | 1:59 a.m.

Sometimes, life throws things at you. What you decide to do with them can mean nothing.

Or it can mean everything.

Like when Alyssa Crittenden was an undergraduate and she took an introduction to evolution class at the University of California, Santa Cruz.

Whoa. Blew. Her. Away.

"It changed my life," said Crittenden, now an anthropology professor at the University of Nevada, Las Vegas whose most recent study is shaking up the way anthropologists think about the evolution of the human diet.

After that first class threw her a curve ball, Crittenden handled it like this: She gave up on being a doctor, she changed her major, she went on to get a doctorate degree, she decided to study the Hazda people in east Africa, and she noticed something kind-of odd living out there in the bush.

The Hazda simply love honey.

Yes, you're saying right now, of course they love honey. Who doesn't love honey? It's yummy!

Well, yes. But. Would you risk your life to get it?

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Honey's Effects On Human Evolution Excite Unlv Anthropologist