WSU recruits geneticists in new research venture

Washington State University is recruiting two genetics researchers to its Spokane campus to launch a $15 million enterprise that will add 135 pharmaceutical scientists.

It's a bold research and job creation that relies, in part, on leveraging a $1.2 million investment of local tax dollars with federal, state and private funds.

"These are people and projects that can be a real catalyst for Spokane," said Susan Ashe, acting executive director of the Health Sciences & Services Authority of Spokane County.

Called the HSSA, the authority was established several years ago to capture a sliver of the local-option sales taxes collected in the Spokane area to help pay for projects designed to create a thriving research cluster here.

If successful, the projects will turn into either sustained research facilities that create jobs, or they will produce ideas or goods that can be commercialized.

Philip Lazarus, a professor and researcher at Penn State University's College of Medicine, has been offered a position to erect a new academic and research program at WSU, a rare opportunity that WSU is dangling as a recruitment tool along with a generous financial package.

The authority is contributing $500,000 over two years to help bring Lazarus to Spokane and set up his program.

"This is pretty exciting stuff. An opportunity in academic research to really create something with your stamp on it," said Gary Pollack, WSU vice provost for health sciences.

Lazarus would work as WSU's chairman of pharmaceutical sciences at the Spokane campus starting in 2014.

His area of expertise is molecular genetics. Specifically, Lazarus is interested in pharmacogenomics. He would bring his independent, federally funded research with him.

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Bioinformatics Market Outlook to 2015

NEW YORK, March 15, 2012 /PRNewswire/ --Reportlinker.com announces that a new market research report is available in its catalogue:

http://www.reportlinker.com/p0795432/Bioinformatics-Market-Outlook-to-2015.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Genomics

During the past decade, the bioinformatics market has significantly evolved across the globe on back of rising genomics industry. The increasing application of genomics in biotech and pharmaceutical research and development has created a huge commercial market for bioinformatics worldwide. As per our latest research report's estimation, the global bioinformatics market, which reached the mark of around US$ 3 Billion in 2010, will expand at a CAGR of around 25% during 2012-2015 as the declining cost of human genome sequencing and increasing public and private sector investment will give a significant boost to the industry.

According to "Bioinformatics Market Outlook to 2015", the content market that includes specialized and generalized databases was the biggest segment of the global bioinformatics industry in 2010, followed by analysis software & services and IT infrastructure. As per our analysis, the software segment is likely to exhibit strong performance in future, improving its share in the overall market. On the other hand, content/database market will suffer the downturn due to the increasing popularity of innovative analysis software. We have also discussed in the report how the free databases would impact the sales of the paid ones.

Our report analyzed the wide application of bioinformatics in genomics, proteomics and pharmacogenomics. A further in-depth study of the market revealed that genome studies have completely transformed cancer research in the past few years and oncology has become the leading therapeutic area supported by bioinformatics. We also observed that small firms in the field are opting for outsourcing route to expand their presence. The other key trends and drivers pushing the market have also been elaborated in the comprehensive research study.

The market has witnessed the launches of key bioinformatics products and services in various areas, and we have evaluated these on the basis of their companies and countries in our report. The research includes country-level analysis and looks into the recent developments that may impact the industry's future performance in a significant manner. By providing a brief profile of key market players like Accelrys and Affymetrix and evaluating their recent activities in the study, we have presented the industry's competitive landscape. Overall, the report aims at providing an in-depth knowledge about the global bioinformatics market to clients and investors.1. Analyst View2. Research Methodology3. Key Industry Trends and Drivers3.1 Increasing Bioinformatics R&D Efforts by Players3.2 Strategic Collaborations Aimed at Enhancing Innovations3.3 Financial Support by Governments Strengthening Bioinformatics Research3.4 Oncology Research - Leading Therapeutic Area Being Aided by Bioinformatics3.5 Small Firms Enlarging Presence through Bioinformatics Outsourcing3.6 IT and Internet Growth Boosting Usage of Bioinformatics Tools4. Market Overview4.1 By Segment4.1.1 Analysis Software & Services4.1.2 Content/Database4.1.3 IT Infrastructure4.2 By Application4.2.1 Genomics4.2.2 Proteomics4.2.3 Pharmacogenomics5. Prominent Country Profile5.1 US5.2 UK5.3 Japan5.4 India5.5 China5.6 South Korea5.7 Taiwan5.8 Singapore5.9 Australia6. Recently Commercialized Products and Services7. Key Players7.1 Accelrys, Inc.7.2 Affymetrix, Inc.7.3 Compugen Ltd.7.4 IBM Life Sciences7.5 Kinexus

List of Figures:

Figure 4-1: Global - Cost of Genome Sequencing (US$), 1990 to 2015Figure 4-2: Global - Bioinformatics Market (Billion US$), 2010-2015Figure 4-3: Global - Bioinformatics Market by Segment (%), 2010Figure 4-4: Global - Analysis Software & Services Market (Million US$), 2010-2015Figure 4-5: Global - Content Market (Million US$), 2010-2015Figure 4-6: Global - IT Infrastructure Market (Million US$), 2010-2015Figure 4-7: Global - Bioinformatics IT Infrastructure Market by Segment (%), 2010Figure 4-8: Global - DNA Sequencing Market (Billion US$), 2010-2015Figure 4-9: Global - Proteomics Market (Billion US$), 2010-2015Figure 4-10: Global - Pharmacogenomics Market by Segment (%), 2009Figure 5-1: UK - Bioinformatics Market (Million US$), 2010-2015Figure 5-2: India - Bioinformatics Market (Billion INR), 2010-2015Figure 5-3: South Korea - Bioinformatics Market (Million US$), 2010-2015

List of Tables:

Table 4-1: Key Molecular Dynamics SoftwareTable 4-2: Key Molecular Modeling SoftwareTable 4-3: Key Open Source Bioinformatics SoftwareTable 4-4: Types of Generalized DatabasesTable 4-5: Types of Specialized DatabasesTable 4-6: Top Countries for High Content Analysis ResearchTable 4-7: Growth in Key Bioinformatics Databases (Dec 2010 & Dec 2011)Table 4-8: Top Countries for DNA Sequence Analysis ResearchTable 4-9: Key Genome Interpretation Databases and ResourcesTable 4-10: Available Data Sources and Gene Prioritization ToolsTable 4-11: Single Nucleotide Variants Interpretation ToolsTable 4-12: Top Countries for Proteomics ResearchTable 4-13: Mass Spectrometry E-ProgramsTable 4-14: 2-DE E-DatabasesTable 4-15: Key Pharmacogenomic DatabasesTable 4-16: Top Ten PharmGKB Gene, Drug, Disease and Pathway Pages (2009)Table 5-1: Top Countries for Bioinformatics ResearchTable 6-1: Recently Commercialized Bioinformatics ProductsTable 6-2: Recently Commercialized Bioinformatics Services

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Eye health is related to brain health

Public release date: 14-Mar-2012 [ | E-mail | Share ]

Contact: Rachel Seroka rseroka@aan.com 651-695-2738 American Academy of Neurology

ST. PAUL, Minn. People with mild vascular disease that causes damage to the retina in the eye are more likely to have problems with thinking and memory skills because they may also have vascular disease in the brain, according to a study published in the March 14, 2012, online issue of Neurology, the medical journal of the American Academy of Neurology.

Damage to the retina is called retinopathy. In the study, the damage was mild enough to not cause significant symptoms.

"Problems with the tiny blood vessels in the eye may be a sign that there are also problems with the blood vessels in the brain that can lead to cognitive problems," said study author Mary Haan, DrPH, MPH, of the University of California, San Francisco. "This could be very useful if a simple eye screening could give us an early indication that people might be at risk of problems with their brain health and functioning."

The study involved 511 women with an average age of 69. The women took tests of their thinking and memory skills every year for up to 10 years. Their eye health was tested about four years into the study and scans were taken of their brains about eight years into the study.

A total of 39 women, or 7.6 percent, had retinopathy. The women with retinopathy on average had lower scores on the cognitive tests than the women who did not have retinopathy. The women with retinopathy also had more areas of small vascular damage within the brain, with 47 percent larger volumes of areas of damage than women who did not have retinopathy. In the parietal lobe of the brain, the women with retinopathy had 68 percent larger volumes of areas of damage.

The results remained the same even after adjusting for high blood pressure and diabetes, which can be a factor in vascular issues in the eye and the brain.

On a test of visual acuity, the women with retinopathy had similar scores as the women without the disease.

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Eye health is related to brain health

Fighting cancer with nanotechnology

Public release date: 14-Mar-2012 [ | E-mail | Share ]

Contact: James Cohen cohen@kavlifoundation.org The Kavli Foundation

Imagine a test that sifts through millions of molecules in a drop of a patient's blood to detect a telltale protein signature of a cancer subtype, or a drug ferry that doesn't release its toxic contents until it slips inside cancer cells.

These and other nanotechnologies could be game changers in how we diagnose, monitor and treat cancer, according to Mark Davis, Professor of Chemical Engineering at the California Institute of Technology, and a member of the Experimental Therapeutics Program of the Comprehensive Cancer Center at the City of Hope.

Davis discussed how nanotechnology was revolutionizing the battle against cancer when he gave the Fred Kavli Distinguished Lectureship in Nanoscience at the fall meeting of the Materials Research Society a lecture that has since become available on the web. Focusing on nanoparticles, Davis said during the lecture, "We're trying to create these nanoscale particles for solid tumors [and] there really is, in my opinion, a very high potential to creat new types of therapies and allow people to have a high quality of life."

Later discussing these advances with three other researchers, Davis elaborated, saying, "What's really exciting to me is the patient evidence that reveal nanoparticles are actually going into tumor cells and releasing their payloads [We're also] starting to see preliminary evidence that these therapies are having some effects in patients while also giving them a high quality of life."

According to Michael Phelps, Norton Simon Professor, and Chair of Molecular and Medical Pharmacology at the University of California Los Angeles, another promising technology is PET molecular imaging probes, which can rapidly search for cancer throughout all tissues of the body, as well as characterize each cancer lesion it detects within an individual patient. "All cancer treatments are in need of better molecular diagnostics... to better characterize the biology of cancer," said Phelps.

"Nanotechnology is an amazing discovery tool ...giving us a new set of eyes that are opening up a whole new world," said James Heath, Professor of Chemistry at Caltech and a founding Board member of Caltech's Kavli Nanoscience Institute. "All evidence suggests that when you do careful engineering of these nanotechnologies, the benefits are great."

Anna Barker agreed. The Former Deputy Director of the National Cancer Institute (NCI) and current Director of Arizona State University's Transformative Healthcare Networks, she said, "The nanotechnologies that are currently in use in the cancer community are actually making cancer therapies safer. They are uniformly increasing the efficiency, while reducing the toxicity for patients."

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Fighting cancer with nanotechnology

Nanotechnology Art Exhibition at the Nanotech Commercialization Conference

DURHAM, N.C.--(BUSINESS WIRE)--

Cutting-edge artists from across the world will participate in the Art of the Small, a juried exhibition held in conjunction with the Nanotech Commercialization Conference (http://www.nanoevent.org), April 4-5, 2012 at the American Tobacco Campus, in Durham, NC. Artists were invited through an open call to exhibit work inspired by nanotechnology, nanobiotech, biotechnology, genomics, DNA, and genetics. Winning artists in several categories will receive a cash award to be announced at the awards and VIP reception. The art exhibition is open to the public on Wednesday, April 4, 2012 from 5 to 7pm at Bay 7 of the American Tobacco Campus in Durham, NC.

Nanotechnology is rapidly transforming industries from medicine to manufacturing to energy. Since the passage of the 21st Century Nanotechnology R&D Act by the U.S. Congress, billions of dollars have been invested in the science of nanotechnology which is rapidly becoming the business of nanotechnology, creating thousands of new start-ups, bolstering nearly every industry across the globe, creating jobs, and bringing life changing innovations to market. The field has also inspired a new category of art, whereby the forms and images of the atomic world are being transformed into new forms of art by the scientific and artistic communities.

The show will be curated by artist and NanoBusiness Alliance founder, F. Mark Modzelewski, an installation artist, who has shown at galleries around the world and curated numerous shows in Boston, Washington DC, and New York. A panel of expert judges drawn from the worlds of art, science, and science communication will select the winning entries. The art will be judged on three key criteria: depiction and representation of the theme, creativity of image representation and innovation in style or technique.

Its inspiring to see these inventive and expressive worlds collide to create new art forms, said Griffith Kundahl, Executive Director of The Center of Innovation for Nanobiotechnology (COIN). We are delighted to support and showcase this artwork at this nanotech conference in Durham, a city well-known for both the arts and sciences.

My career has combined duel passions for art and technology, noted curator F. Mark Modzelewski. I am excited by this opportunity to work with COIN to expose leaders in the nanotech and biotech communities to leading artists from around the world that are taking science and transforming it into art.

Dozens of entries have flooded in from leading figures in the art and science fields, from countries ranging from the United States to Cyprus to South Korea. Following the conference, images of the works from the exhibition will appear in an online gallery supported by COIN for a period of 36 months.

Sponsors for the event and exhibition include:

NanoBCA: The NanoBusiness Commercialization Association (NanoBCA) http://www.nanobca.org is a 501(c)(6) trade organization lead by Vincent Caprio http://www.vincentcaprio.org, Executive Director, dedicated to promoting the commercialization of nanotechnology and helping companies bring affordable, life-improving nanotech products to the market. Founded in 2001, the organization has been at the forefront of policy and advocacy for the nanotechnology community for over a decade.

NCBST: In 1963, the North Carolina General Assembly established the North Carolina Board of Science & Technology to encourage, promote, and support scientific, engineering, and industrial research applications in North Carolina. To meet these goals, the Board works to investigate new areas of emerging science and technology and conducts studies on the competitiveness of state industry and research institutions in these fields. The Board also works with the General Assembly and the Governor to put into place the infrastructure that keeps North Carolina on the cutting edge of science and technology.

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Nanotechnology Art Exhibition at the Nanotech Commercialization Conference

‘World beating’ 3D printer enables nano-precision

Printing three dimensional objects with incredibly fine details is now possible using two-photon lithography. With this technology, tiny structures on a nanometer scale can be fabricated.

Researchers at the Vienna University of Technology (TU Vienna) have made a breakthrough in speeding up this printing technique: Their high-precision-3D-printer is claimed to be orders of magnitude faster than similar devices, as this video shows.

The scientists say that this achievement enables new application areas, such as in medicine. The 3D printer uses a liquid resin, which is hardened at precisely the correct spots by a focused laser beam. The focal point of the laser beam is guided through the resin by movable mirrors and leaves behind a hardened line of solid polymer, just a few hundred nanometers wide.

This high resolution enables the creation of intricately structured sculptures as tiny as a grain of sand. Until now, this technique used to be quite slow, says Professor Jrgen Stampfl from the Institute of Materials Science and Technology at the TU Vienna. The typical printing speed used to be measured in millimeters per second but now our device can print five meters in one second.

In two-photon lithography, this is a world record achievement.

Jan Torgersen, also working at the TU Vienna, continues, This amazing progress was made possible by combining several new ideas. It was crucial to improve the steering mechanism of the mirrors.

The mirrors are continuously in motion during the printing process. The acceleration and deceleration-periods have to be tuned precisely to achieve high-resolution results at the record-breaking speed.

Photoactive molecules harden resin

Torgersen adds that 3D-printing is not all about mechanics: Chemists had a crucial role to play in this project too. The resin contains molecules that are activated by the laser light, which induce a chain reaction in other components of the resin, the monomers, and turn them into a solid.

These initiator molecules are only activated if they absorb precisely two photons of the laser beam at once and this only happens in the center of the laser beam, where the intensity is highest.

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Flu Drug Could Aid Recovery Of Brain

Flu Drug Could Aid Recovery Of Brain

Can Help Victims Of Car Accidents

(AP) Researchers are reporting the first treatment to speed recovery from severe brain injuries caused by falls and car crashes: a cheap flu medicine whose side benefits were discovered by accident decades ago.

Severely injured patients in the U.S., Denmark and Germany who were given amantadine got better faster than those who received a dummy medicine. After four weeks, more people in the flu drug group could give reliable yes-and-no answers, follow commands or use a spoon or hairbrushthings that few of them could do at the start. Far fewer patients who got amantadine remained in a vegetative state, 17 percent versus 32 percent.

This drug moved the needle in terms of speeding patient recovery, and thats not been shown before, said neuropsychologist Joseph Giacino of Bostons Spaulding Rehabilitation Hospital, co-leader of the study. He added: It really does provide hope for a population that is viewed in many places as hopeless.

Many doctors began using amantadine for brain injuries years ago, but until now theres never been a big study to show that it works. The results of the federally funded study appear in Thursdays New England Journal of Medicine.

A neurologist who wasnt ina. volved in the research called it an important step. But many questions remain, including whether people less severely injured would benefit, and whether amantadine actually improves patients long-term outcome or just speeds up their recovery.

Each year, an estimated 1.7 million Americans suffer a traumatic brain injury. Falls, car crashes, colliding with or getting hit by an object, and assaults are the leading causes. About three-quarters are concussions or other mild forms that heal over time. But about 52,000 people with brain injuries die each year and 275,000 are hospitalized, many with persistent, debilitating injuries, according to government figures.

With no proven remedies to rely on, doctors have used a variety of medicines approved for other ailments in the hopes that they would help brain injury patients. Those decisions are based on hunches and logic rather than data, said Dr. John Whyte, of the Moss Rehabilitation Research Institute in suburban Philadelphia. He led the study along with Giacino.

Amantadine, an inexpensive generic, was approved for the flu in the mid-1960s. The first hint that it might have other uses came a few years later when it appeared to improve Parkinsons symptoms in nursing home patients. It was found to have an effect on the brains dopamine system, whose many functions include movement and alertness, and it was later approved for Parkinsons.

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3-D printer with nano-precision sets world record

Summary: Researchers at the Vienna University of Technology have developed a method for fabricating intricately structured sculptures as tiny as a grain of sand in record speed.

Using a technique known as two-photon lithography, Austrian researchers have developed a high-precision 3-D printer capable of producing nanometer-sized objects in the shape of race cars, cathedrals and bridges all in a matter of minutes.

The high-precision 3-D printer at TU Vienna is purportedly orders of magnitude faster than similar devices and opens up new areas of applications, such as in medicine.

The super-fast nano-printer uses a liquid resin, which is hardened at precisely the correct spots by a focused laser beam. The focal point of the laser beam is guided through the resin by movable mirrors; it leaves behind a hardened line of solid polymer just a few hundred nanometers wide. The result is a detailed sculpture measuring a couple hundred micrometers in length.

Until now, this technique used to be quite slow, said Professor Jrgen Stampfl from the Institute of Materials Science and Technology at the TU Vienna. The printing speed used to be measured in millimeters per second our device can do five meters in one second. In two-photon lithography, this is a world record.

The scientists at TU Vienna are now developing bio-compatible resins for medical applications that can be used to create scaffolds to which living cells can attach themselves for the systematic creation of biological tissues. The 3-D printer could also be used to create tailor-made components for biomedical technology or nanotechnology.

The video below shows the 3-D printing process in real time. The very fast control mechanism connected to the laser beam produces 100 layers, consisting of approximately 200 single lines each, in four minutes.

Source: Vienna University of Technology

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3-D printer with nano-precision sets world record

Researcher at UMDNJ-New Jersey Medical School Receives Grand Challenges Tuberculosis Biomarkers Grant

Newswise NEWARK, N.J. -- The University of Medicine and Dentistry of New Jersey (UMDNJ) announced today that Dr. David Alland, professor of medicine, chief of infectious diseases, and director of the Center for Emerging and Re-Emerging Pathogens at UMDNJ-New Jersey Medical School, will receive a tuberculosis (TB) biomarkers grant awarded by the Bill & Melinda Gates Foundations Grand Challenges in Global Health program, an initiative which seeks to overcome persistent bottlenecks in creating new tools that can radically improve health in the developing world.

With the grant, awarded through the Foundation of UMDNJ, Dr. Alland will pursue an innovative research project to identify and validate TB biomarkers, titled Permeable Magnetic Nanoparticles for point-of-care tuberculosis diagnosis.

The Grand Challenges TB biomarkers program provides funding for groundbreaking research into TB biomarkers for the development of a low-cost, simple to use tool that can quickly and accurately diagnose TB in developing countries.

There is an urgent need to break through barriers in biomarker research in order to develop a highly-sensitive point-of-care diagnostic to improve identification of active TB cases, said Chris Wilson, director of Global Health Discovery at the Bill & Melinda Gates Foundation. We hope these innovative ideas lead to effective and affordable TB diagnostics that can make an impact on one of the worlds deadliest infectious diseases.

Dr. Allands project is one of ten Grand Challenges TB biomarkers grants awarded by the Bill & Melinda Gates Foundation.

Diagnostic assays are important components of tuberculosis (TB) control programs. Numerous methods exist that can rapidly detect Mycobacterium tuberculosis (MTB) in patient sputum (and potentially in other clinical samples). However, a major limitation common to virtually every one of these methods lies in the difficulty of extracting MTB from the clinical sample. This project will develop a simple, rapid and sensitive method to magnetically extract MTB from any volume of sputum that can reasonably be produced by a patient. MTB extracted with this method will be suitable for detection by many downstream technologies that can be adapted to point of care detection. This project will overcome a major roadblock in TB diagnostics, enabling many innovative diagnostic platforms to be applied to detecting this disease.

About Grand Challenges in Global Health The Bill & Melinda Gates Foundation recognizes that solving our greatest global health issues is a long-term effort. Through Grand Challenges in Global Health, the foundation is committed to seeking out and rewarding not only established researchers in science and technology, but also young investigators, entrepreneurs and innovators to help expand the pipeline of ideas to fight diseases that claim millions of lives each year. We anticipate that additional grants will be awarded through the Grand Challenges program in the future.

About UMDNJ and the Center for Emerging Pathogens The University of Medicine and Dentistry of New Jersey (UMDNJ) is New Jerseys only health sciences university with more than 6,000 students on five campuses attending the state's three medical schools, its only dental school, a graduate school of biomedical sciences, a school of health related professions, a school of nursing and New Jerseys only school of public health. UMDNJ operates University Hospital, a Level I Trauma Center in Newark, and University Behavioral HealthCare, which provides a continuum of healthcare services with multiple locations throughout the state.

The Center for the Study of Emerging and Reemerging Pathogens is a collection of interdepartmental laboratories located in the Medical Science Building at the UMDNJ-New Jersey Medical School in Newark.

These laboratories share a new facility containing many pieces of top of the line/state-of-the-art equipment, used in scientific research. The facility comprises modern rooms dedicated to different purposes such as cell culture equipped with carbon dioxide incubators and a Biological Safety Cabinet, dishwashing and autoclaving (two dishwashers, two drying ovens and two autoclaves for sterilization), darkroom, PCR room, common equipment room containing gel dryers, ultracentrifuges, a lyopholizer, a tabletop centrifuge, & a scintillation counter.

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Researcher at UMDNJ-New Jersey Medical School Receives Grand Challenges Tuberculosis Biomarkers Grant

AMSA hosts medical school made easy event

Published:Wednesday, March 14, 2012

Updated:Wednesday, March 14, 2012 21:03

The process of applying for medical school could seem somewhat overwhelming for prospective students. To help alleviate some of this stress and help students better prepare for applications, The American Medical Student Association (AMSA) will be hosting their second annual Medical School Process Made Easy event on Saturday, March 17 in the D.P. Culp Auditorium. This event will provide a step-by-step guide to applying for medical school. It was really a success last year, said Casey Lawson, chair of the event. We had a little over 100 students show up. This year we have kind of expanded it where its not just ETSU. The admissions director of ETSUs Quillen College of Medicine has sent out emails to neighboring schools, Lawson said. Students from Western Carolina, Virginia Intermont, Carson-Newman and King have all signed up. Registration is free and is open to all students who are interested in attending. The event is able to host up to 200 students, and spots are still available. We want to make sure we have enough resources to make sure we can manage what we need to do, Lawson said. This event will include mock interviews, a dress and appearance seminar, an application workshop, and a current events seminar. The AMSA and Captain Carlson of the U.S. Army will sponsor a free lunch for those who attend. Doug Taylor, dean of admissions, will also be speaking to talk to students about what people see when an application is being viewed. It really helped a lot last year and we got some really great feedback, Lawson said. We want to get some surveys after this time to get some more feedback and see what we can improve to make it better. Hopefully this will continue. Medical School Process Made Easy will be open to anyone considering medical school as an opportunity to see if the student is really dedicated enough to do all the things they have to do, but it is primarily targeted for people who are set on going, said Lawson. If youre serious, you need to have the information ahead of time so you can prepare. Josh Eckelberry, biology major with a concentration on biochemistry, attended the event last year and highly recommends it for anyone considering medical school. Its been a big help working on applications. It makes you realize what it takes Even if youre not premed, its really helpful for an job interview and having interview skills. They have a nice workshop with that. It was a big help, and kind of an eye opener. The event begins at 12:30 p.m. in the Culp Center Auditorium, but attendees should arrive at noon to talk to the medical schools, which will be set up at that time. Everyone will be set up in the Atrium, and the event will last until approximately 7 p.m. In the last 45 minutes of the event, a medical school committee members and staff and student will be on stage to answer questions. To register, go to http://www.etsu.edu/cas/mpa/default.aspx.

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AMSA hosts medical school made easy event

Match Day and the Long Road to Becoming a Medical Resident

Released: 3/15/2012 12:00 PM EDT Source: Mayo Clinic Expert Available

Mayo Clinic Experts Available to Discuss Tools to Identify Medical School Burnout

Newswise ROCHESTER, Minn. Medical school students around the country will learn their fate this Friday, March 16, on what is known as Match Day. This is a much-anticipated day that reveals not only where they will work after medical school, but what medical specialty they will pursue. Match Day is filled with excitement and celebration there are hugs, cheers, high fives and tears, but there is another aspect of becoming a resident that medical schools, hospitals and veteran physicians are increasingly paying attention to: The road to becoming a resident is not easy and can lead to burnout ranging from emotional and physical exhaustion to depersonalizing patients.

There has been a growing recognition of burnout among medical students and such distress can have a big impact on their quality of life, professional development and patient care. Mayo Clinic experts have developed an index that screens medical students to identify burnout, symptoms of depression, sleepiness and fatigue. Studies using the index have provided evidence of reliability and validity using the tool to identify severe distress in medical students.

Mayo Clinic experts, Lotte Dyrbye, M.D., associate director, Department of Medicine Program on Physician Well-Being, and Tait Shanafelt, M.D., director, Department of Medicine Program on Physician Well-being at Mayo Clinic, are available to talk about the index and ways for students to identify burnout and ways to promote personal well-being and professional satisfaction to foster a high quality of care for patients and a high quality of life for themselves throughout their medical careers. Dr. Dyrbye and Dr. Shanafelt have conducted several studies on physician burnout, most recently examining the causes and consequences of prolonged stress among oncologists.

Match Day reveals the results of a two-way selection process: matching the top preferences for residency programs among medical students with the needs of residents among residency programs throughout the United States. The Match Day event also marks each participant's progression from student to practicing physician.

### About Mayo Clinic Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit http://www.mayoclinic.org/about/ and http://www.mayoclinic.org/news.

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Match Day and the Long Road to Becoming a Medical Resident

Medical School Tips for Success

Considering medical school? Use these pointers and suggestions to help you determine if a career in medicine is right for you.

Smart Choices

Embarking on the path to become a doctor is a lengthy process. It takes a total of at least 11 years: 4 years of college; 4 years of medical school; and at least 3 years of in-hospital training. (Some programs require up to 8 years of residency and internship training.)

The medical school applicant pool continues to increase, up to 43,919 in 2011 from 42,742 in 2010, according to the Association of American Medical Colleges (AAMC). Prospective students submitted an average of 14 applications each for the 2011-2012 school year, for a total of 609,312 applications to medical schools.

[See the Best Medical Schools rankings.]

Getting In

It's important to build a base of knowledge during your undergraduate academic career. Medical school applicants should have a strong background in math and science, especially biology, general chemistry, organic chemistry, and physics. Being a doctor also requires good people skills, and a solid foundation of liberal arts courses such as humanities and social sciences helps, too.

Extracurricular activities like volunteering at a local hospital or medical clinic may make your application stand out, according to the AAMC, and can also be a good way to develop professional relationships that may lead to medical school letters of recommendation.

About 90 percent of medical school applicants apply during their junior year of college and start medical school right after college. Others take time off after graduation or go through an early admissions or accelerated program while they are still undergraduate students.

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Medical School Tips for Success

6 Surprising Behaviors That Age You

When you think of factors that prematurely age you, your mind probably turns to smoking, overeating, or excessive stress. And if you've been following the news, you might add tanning to the list (it makes you more susceptible to skin cancer--and we won't even get started on the wrinkles and sun spots.) But what you might not know is that your exercise patterns, listening habits, and even your cooking style can negatively affect your life. Luckily, you can make changes. Read on for tips on how to counteract these six surprising behaviors that age you:

[See: Popular but Dangerous: 3 Vitamins That Can Hurt You]

Overheating your food. Think twice before constantly grilling and frying your meals. Foods cooked at high temperatures can produce compounds that increase inflammation, which damages the body's cells and is increasingly fingered as a driver of many diseases, such as cancer. The highest levels of these compounds, called advanced glycation end products (AGEs), are in fatty foods and meats (think steak), while the lowest levels are in carbohydrate-rich foods like vegetables, says Melina Jampolis, a physician nutrition specialist and author of The Calendar Diet: A Month by Month Guide to Losing Weight While Living Your Life. "Longer cooking time, higher heat, and less moisture during cooking affect levels formed," she explains. Just like the acronym states, AGEs are thought to speed up the aging process, and they have been linked to heart disease, diabetes, and other age-related diseases, she says. Try cutting back on fast food, processed-packaged foods, and higher-fat meats, and eating fruits and veggies rich in antioxidants, like grapefruit and spinach, to prevent the formation of AGEs, she says. (Drinking tea and a little red wine counts, too.) Also helpful: Cooking foods at lower temperatures for longer periods of time, and increasing moisture during cooking. So steam that shrimp instead of sauting it!

[See: Red Meat Shortens Life? What to Do]

Running uphill or up stairs. All running isn't always good. Uphill running (in particular) places additional stress on the knees and ankles, reports the American Orthopaedic Society for Sports Medicine. "There is at least a four-fold increase placed on our knee joint [with uphill running], and this can lead to premature breakdown of cartilage, also known as arthritis," says Moshe Lewis, chief of physical medicine and rehab at California Pacific Medical Center, St. Luke's Campus. If you're just beginning a running program, the AOSSM cautions against uphill running at first. Even if you're an experienced runner, take care with steep inclines. After all, the ideal running surface is "flat, smooth, resilient, and reasonably soft," says the AOSSM.

Listening to loud music and loud noises. Yes, blasting your favorite songs is fun, but if you keep doing it, you may not get to enjoy those tunes in a few years. That's because loud noises can put you at risk for premature hearing loss, with sounds louder than 85 decibels able to cause permanent loss, reports the American Speech-Language-Hearing Association. A blow dryer is 80 to 90 decibels, the subway is 90 decibels, and the maximum output of some MP3 players is 110 decibels, ASHA reports. In fact, MP3 players pose a serious hazard to hearing to which teens are especially vulnerable, according to recent research from Tel Aviv University. To enjoy music for years to come, listen to your MP3 player at half volume, ASHA advises. And if you don't have protection, like ear plugs, don't expose yourself to loud noises for prolonged periods.

[See: 11 Health Habits That Will Help You Live to 100]

Bad posture when using tech devices. When you gaze down at a tech device, especially when it's in your hand or lap, your posture suffers. "Poor posture mechanics lead to rounded shoulders and neck strain," says Lewis. But you don't have to give up your beloved tablet laptop or smartphone to avoid being permanently hunched over. Just place your device higher up--like on a table--to prevent lower-gaze angles, suggests a recent study by Harvard School of Public Health researchers. Also sit straight up, and take breaks every 10 minutes, says Lewis. "The damage can be reversed," he says, "but there is a limited window."

Not maintaining your balance. As we age, we lose our balance, which can spell falls and fractures. (Each year, more than 1.6 million older Americans land in the emergency room because of fall-related injuries, according to the National Institute on Aging.) "Balance goes unnoticed until it's gone," says Lorraine Maita, a New Jersey-based internist and author of Vibrance for Life: How to Live Younger and Healthier. But you don't have to lose it. To avoid being off-balance before your time, "try sports that require agility, like tennis," she says. Stability balls, yoga, and dance are also good bets.

Not wearing sunglasses. You must protect your eyes from UV radiation. Spending long hours exposed to these rays without adequate protection can raise the risk of cataracts (a clouding of the eye lens that can blur vision), snow blindness (a temporary burn to the cornea), and skin cancer around the eyelids, according to the Environmental Protection Agency. If you're around snow, water, or sand, know that these elements reflect UV rays, which can amplify the amount reaching your eyes and skin. The fix: Wear sunglasses outside, even on cloudy days, advises the EPA. Make sure the label says they block 99 to 100 percent of UVA and UVB rays. And if your new shades make you look good, too? Well, that's just a bonus.

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6 Surprising Behaviors That Age You

First-ever integrative 'Omics' profile lets Stanford scientist discover, track his diabetes onset

Public release date: 15-Mar-2012 [ | E-mail | Share ]

Contact: Krista Conger kristac@stanford.edu 650-725-5371 Stanford University Medical Center

STANFORD, Calif. Geneticist Michael Snyder, PhD, has almost no privacy. For more than two years, he and his lab members at the Stanford University School of Medicine pored over his body's most intimate secrets: the sequence of his DNA, the RNA and proteins produced by his cells, the metabolites and signaling molecules wafting through his blood. They spied on his immune system as it battled viral infections.

Finally, to his shock, they discovered that he was predisposed to type-2 diabetes and then watched his blood sugar shoot upward as he developed the condition during the study. It's the first eyewitness account viewed on a molecular level of the birth of a disease that affects millions of Americans. It's also an important milestone in the realization of the promise of truly personalized medicine, or tailoring health care to each individual's unique circumstances.

The researchers call the unprecedented analysis, which relies on collecting and analyzing billions of individual bits of data, an integrative Personal "Omics" Profile, or iPOP. The word "omics" indicates the study of a body of information, such as the genome (which is all DNA in a cell), or the proteome (which is all the proteins). Snyder's iPOP also included his metabolome (metabolites), his transcriptome (RNA transcripts) and autoantibody profiles, among other things.

The researchers say that Snyder's diabetes is but one of myriad problems the iPOP can identify and predict, and that such dynamic monitoring will soon become commonplace. "This is the first time that anyone has used such detailed information to proactively manage their own health," said Snyder. "It's a level of understanding of health at the molecular level that has never before been achieved."

The research will be published in the March 16 issue of Cell. Snyder, who chairs the Department of Genetics, is the senior author. Postdoctoral scholars Rui Chen, PhD, George Mias, PhD, Jennifer Li-Pook-Than, PhD, and research associate Lihua Jiang, PhD, are co-first authors of the study, which involved a large team of investigators.

The study provides a glimpse into the future of medicine peppered with untold data-management hurdles and fraught with a degree of self-examination and awareness few of us have ever imagined. And, despite the challenges, the potential payoff is great.

"I was not aware of any type-2 diabetes in my family and had no significant risk factors," said Snyder, "but we learned through genomic sequencing that I have a genetic predisposition to the condition. Therefore, we measured my blood glucose levels and were able to watch them shoot up after a nasty viral infection during the course of the study."

As a result, he was able to immediately modify his diet and exercise to gradually bring his levels back into the normal range and prevent the ongoing tissue damage that would have occurred had the disease gone undiagnosed.

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First-ever integrative 'Omics' profile lets Stanford scientist discover, track his diabetes onset

Revolution in personalized medicine: First-ever integrative 'Omics' profile lets scientist discover, track his …

ScienceDaily (Mar. 15, 2012) Geneticist Michael Snyder, PhD, has almost no privacy. For more than two years, he and his lab members at the Stanford University School of Medicine pored over his body's most intimate secrets: the sequence of his DNA, the RNA and proteins produced by his cells, the metabolites and signaling molecules wafting through his blood. They spied on his immune system as it battled viral infections.

Finally, to his shock, they discovered that he was predisposed to type-2 diabetes and then watched his blood sugar shoot upward as he developed the condition during the study. It's the first eyewitness account -- viewed on a molecular level -- of the birth of a disease that affects millions of Americans. It's also an important milestone in the realization of the promise of truly personalized medicine, or tailoring health care to each individual's unique circumstances.

The researchers call the unprecedented analysis, which relies on collecting and analyzing billions of individual bits of data, an integrative Personal "Omics" Profile, or iPOP. The word "omics" indicates the study of a body of information, such as the genome (which is all DNA in a cell), or the proteome (which is all the proteins). Snyder's iPOP also included his metabolome (metabolites), his transcriptome (RNA transcripts) and autoantibody profiles, among other things.

The researchers say that Snyder's diabetes is but one of myriad problems the iPOP can identify and predict, and that such dynamic monitoring will soon become commonplace. "This is the first time that anyone has used such detailed information to proactively manage their own health," said Snyder. "It's a level of understanding of health at the molecular level that has never before been achieved."

The research was published in the March 16 issue of Cell. Snyder, who chairs the Department of Genetics, is the senior author. Postdoctoral scholars Rui Chen, PhD, George Mias, PhD, Jennifer Li-Pook-Than, PhD, and research associate Lihua Jiang, PhD, are co-first authors of the study, which involved a large team of investigators.

The study provides a glimpse into the future of medicine -- peppered with untold data-management hurdles and fraught with a degree of self-examination and awareness few of us have ever imagined. And, despite the challenges, the potential payoff is great.

"I was not aware of any type-2 diabetes in my family and had no significant risk factors," said Snyder, "but we learned through genomic sequencing that I have a genetic predisposition to the condition. Therefore, we measured my blood glucose levels and were able to watch them shoot up after a nasty viral infection during the course of the study."

As a result, he was able to immediately modify his diet and exercise to gradually bring his levels back into the normal range and prevent the ongoing tissue damage that would have occurred had the disease gone undiagnosed.

Snyder provided about 20 blood samples (about once every two months while healthy, and more frequently during periods of illness) for analysis over the course of the study. Each was analyzed with a variety of assays for tens of thousands of biological variables, generating a staggering amount of information.

The exercise was in stark contrast to the cursory workup most of us receive when we go to the doctor for our regular physical exam. "Currently, we routinely measure fewer than 20 variables in a standard laboratory blood test," said Snyder, who is also the Stanford W. Ascherman, MD, FACS, Professor in Genetics. "We could, and should, be measuring many, many thousands."

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Revolution in personalized medicine: First-ever integrative 'Omics' profile lets scientist discover, track his ...

Diet For Super Sperm? Cut Saturated Fat, Up Omega-3 Intake: Study

A higher intake of saturated fat damages the quality of men's sperm, according to a new study published in the online journal Human Reproduction.

The study of 99 men who attend fertility clinics, which measured fatty acid levels in sperm and seminal plasma, found that "higher total fat intake was negatively related to total sperm count and concentration."

The study's participants were 89 percent Caucasian with an average age of 36.4 years. More than 7 in 10 men in the study were obese and 61 percent never smoked.

The 33 men with the highest fat intake were found to have a sperm count 43 percent lower than those who were on better diets.

"This association was driven by the intake of saturated," the study found. "Levels of saturated fatty acids in sperm were also negatively related to sperm concentration, but saturated fat intake was unrelated to sperm levels."

Men who had a higher intake of healthy omega-3 fats was positively related to the size and shape of their sperm.

Here are five foods to keep your sperm healthy based on the study's findings:

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1. Salmon

Salmon is high in omega-3 fatty acids as well as protein.

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Diet For Super Sperm? Cut Saturated Fat, Up Omega-3 Intake: Study

Fatty diets linked to reduced sperm quality

Gents, if you want to make sure your swimmers are in tip top shape, you may want to reconsider tucking into the burger and fries.

In a new study published online in the journal Human Reproduction March 13, a team of US researchers found that men who consumed diets high in saturated fats had both lower total sperm count and sperm concentration.

Meanwhile, men who consumed more omega-3 fatty acids, commonly found in fish and plant oils, were found to have slightly more sperm -- about 2 percent -- compared to those with the lowest intake.

For their study, Harvard researchers questioned a group of 99 men from 2006 to 2010 about their diet and analyzed samples of their semen, measuring the levels of fatty acids in their sperm.

The participants -- 71 percent of whom were obese or overweight -- were divided into three groups.

Those in the group with the highest intake of fat had a 43 percent lower sperm count, in addition to 38 percent lower sperm concentration compared to the group who consumed the least amount of fat.

Total sperm count is defined as the total number of sperm in the ejaculate, while sperm concentration denotes the number of sperm per unit volume.

The World Health Organisation defines normal total sperm count as a minimum of 39 million. The concentration of spermatozoa should be at least 15 million per milliliter.

While the researchers acknowledge the small sample size for the study, it's not the first to provide a link between poor diet and sperm quality.

Another Harvard study conducted jointly with researchers from the University of Murcia in Spain found that eating foods high in trans fats reduced the sperm quality in even healthy young men.

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Fatty diets linked to reduced sperm quality

Junk Food Diets Linked To Low Sperm Counts

March 14, 2012

A new report in the journal Human Reproduction showcases a study that links fatty, high-carbohydrate diets to lower sperm counts. A better diet that included high intakes of omega-3 fatty acids, found in fish and plant oils, were associated with higher sperm concentration, reports BBC News.

The team, led by Prof Jill Attaman from Harvard Medical School in Boston, questioned 99 men about their diet and analyzed sperm samples over the course of four years.

Compared with those eating the least fat, men with the highest fat intake had a 43 percent lower sperm count and 38 percent lower sperm concentration. Men consuming the most omega-3 fatty acids had sperm with a more normal structure than men with the lowest intake.

Prof. Attaman said, the magnitude of the association is quite dramatic and provides further support for the health efforts to limit consumption of saturated fat given their relation with other health outcomes such as cardiovascular disease.

However, 71 percent of participants were overweight or obese, which could have had an impact on sperm quality. Furthermore, none of the men had sperm counts or concentrations below the normal levels defined by the World Health Organization of at least 39 million and 15 million per milliliter.

Commenting on the research, British fertility expert Dr. Allan Pacey, of the University of Sheffield, this is a relatively small study showing an association between dietary intake of saturated fats and semen quality.

Perhaps unsurprisingly there appeared to be a reasonable association between the two, with men who ate the highest levels of saturated fats having the lowest sperm counts and those eating the most omega-3 polyunsaturated fats having the highest.

Importantly, the study does not show that one causes the other and further work needs to be carried out to clarify this. But it does add weight to the argument that having a good healthy diet may benefit male fertility as well as being good general health advice.

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Junk Food Diets Linked To Low Sperm Counts

Does Dietary Fat Affect Semen?

Diets high in saturated fat are bad for waistlines, but they can also have a negative impact below the waist. They may lower sperm count and sperm concentration, according to a new study published in the journal Human Reproduction.

Researchers from Massachusetts General Hospital, Brigham and Women's Hospital and Harvard Medical School collected semen samples from 99 mostly overweight or obese men and assessed their diets by asking them how often over the previous year they had certain foods and beverages.

They found that eating a lot of saturated fat was associated with a lower total sperm count and concentration. Diets high in omega-3 polyunsaturated fats -- the fats commonly found in fish and plant oils -- were associated with better-quality semen, meaning the sperm cells were of a better size and shape. The study did not determine what particular kinds of saturated fats were linked to sperm count.

The study's lead author, Dr. Jill Attaman, now a reproductive endocrinologist at Dartmouth-Hitchcock Medical Center, said the study could lead to a better understanding of how lifestyle factors affect male fertility.

"There are few clearly identifiable lifestyle modifications that can be made to optimize natural fertility, especially for males," Attaman told ABC News in an email. "This is the first report of a relation between specific dietary fats and semen quality."

Experts not involved with the study have different opinions on the role diet plays in male fertility. Some say the research opens up an important door to future studies, while others say there are factors that play a much bigger role in fertility.

"The study explores an inadequately studied field in andrology and suggests associations between dietary habits and sperm parameters among subfertile, mostly overweight men," said Dr. Tamer Yalcinkaya, associate professor and section head of reproductive endocrinology and infertility at Wake Forest University School of Medicine.

Diet is an important fertility-related variable, other doctors told ABC News.

"Maintaining a healthy, well-balanced diet will be the key to optimizing sperm parameters," said Dr. John Petrozza, director of the MGH Fertility Center, a center involved in the study. "The concept of omega-3 fatty acids will be the key, since it has been well established as an important cell membrane stabilizer."

"We have been discussing diet with our female patients for quite a while," said Dr. Alan Penzias, associate professor of obstetrics, gynecology and reproductive biology at Harvard Medical School. Researchers at Harvard Medical School were also involved with the study, though Penzias was not. "This evidence is entirely plausible and affords us the opportunity to expand the discussion to the male partners of our female patients."

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Does Dietary Fat Affect Semen?