Mead Johnson, SanCor establish pediatric nutrition JV

DBR Staff Writer Published 16 March 2012

Mead Johnson Nutrition and Argentina-based diary producer SanCor Cooperativas Unidas have officially established a joint venture (JV) to expand the availability of pediatric nutrition products across the Southern Cone of South America.

Mead Johnson Nutrition chief operating officer Kasper Jakobsen and SanCor Cooperativas Unidas of Argentina chairman of board of administration Oscar Carreras met in Buenos Aires to establish the JV.

Mead Johnson will invest ARS850m ($196m) for an 80% ownership interest in the JV, which will develop, produce and market pediatric nutritional products under the SanCor Beb brand at existing facilities in Argentina.

The company will provide clinical research, proprietary formulas and product innovation, while SanCor will contribute its local market knowledge of Argentina and manufacturing capabilities.

Carreras said Mead Johnson strengthens its presence and growth potential in South America, while SanCor is able to better leverage its manufacturing base and continue exploration of business opportunities in other promising categories.

In 2011, SanCor's turnover in the infant formula and children's growing-up milk categories totaled nearly ARS300m ($69m).

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Mead Johnson, SanCor establish pediatric nutrition JV

Droid Razr Maxx's longevity tops Galaxy Note's stylus

Two of the latest gadgets are cases in point. On paper, the Samsung Galaxy Note and the Motorola Droid Razr Maxx have very similar specs. But the two phones are quite distinct, thanks to some unusual features.

The Galaxy Note, available through AT&T, is Samsung's attempt to turn a smartphone into a digital notepad, replete with not only a jumbo 5.3-inch screen, but also a stylus and software that can translate handwritten notes into text.

The Droid Razr Maxx, available through Verizon Wireless, has a more subtle distinction - a battery that the company says will allow users to talk for up to 21 { hours. That's 70 percent longer than the promised talk time on the original Droid Razr, which Motorola released just three months ago and for which the new gadget is a dead ringer.

It's exciting to see smartphone manufacturers exploring new innovations. But in this case, I'd take the subtle over the splashy.

I've not been a fan of the trend toward bigger screens in smartphones. While the extra viewing space is nice, a big-screen device is harder to hold, talk on or fit in your pocket. The Galaxy Note takes this trend to the extreme. It's like the Hummer of smartphones. I felt ridiculous holding this clumsy device up to my ear and found it nearly impossible to use with one hand.

The point of the large screen is to enable the device to behave like a tablet - good for watching movies and composing documents, but in a more portable, than a regular, tablet.

The Galaxy Note's display is bright and crisp, great for viewing videos or reading e-books.

Samsung has included a few applications and built-in features for the device's stylus. You can take handwritten notes in S Memo, finely crop or enhance photos in the device's gallery and direct a ball to its goal by drawing and erasing lines in "Crayon Physics." The game and photo enhancement work OK.

But memo-taking - one of the express purposes of the Galaxy Note - was its most disappointing aspect.

As a reporter, I still often resort to a pen and paper when interviewing subjects or taking notes at conferences. I'd love to be able to replace that antiquated system with a digital notepad that would recognize my handwriting and allow me to take fully searchable notes.

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Droid Razr Maxx's longevity tops Galaxy Note's stylus

Biology students gather at Laurentian

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Students place in regional science fair

Stuttgart School District students came back victorious from the Southeast Regional Science Fair at the University of Arkansas at Monticello.

Stuttgart High School held its science fair back in December, and those students who earned first, second or third places moved on to the University of Arkansas-Pine Bluff Science Fair. The UAPB Science Fair was held Feb. 16 and students that place first, second or third went on to compete in the Regional Science Fair at Monticello on March 8.

Now those who have placed in the regional at Monticello have the opportunity to compete in the state science fair March 30 and 31, SHS teacher Kathy Prislovsky said.

In the Senior Division at Monticello Chris Hooks received first place in Behavioral Science. Lawrence Chamberlain received second place in Behavioral Science. Pearl Jangjiravat received second place in Chemistry. Shana Fruge received first place in Biochemistry. Cassidy George received second place in Cellular/Molecular Biology. Marlee Meier and Aston Coleman received second place in Team.

In the Junior Division Abbey Maynard received third place in Chemistry. Corbin Buerkle received first place in Microbiology. Ashley Hopson and Jaelyn Maddox received third place in Team.

Chamberlain was the overall winner of the science fair at UAPB receiving a four-year scholarship and the Sigma Xi Fraternity award with a $100 prize. Hooks was the winner of the science fair in Monticello and won a one-year scholarship at UAM.

Each year we try this same sequence local science fair, UAPB science fair, regional science fair, then state, Prislovsky said. Last year we had a couple students qualify for state, but couldnt attend.

You cant imagine how proud the science department and the high school are of these students.It is an honor, and I am excited that they wanted to continue on with their projects, she said.

It is important for the students to compete in these competitions because it helps them with the presentation skills and also their self-esteem, Prislovsky explained.

It also is wonderful that they enjoy doing science. STEM is where we are heading, science, technology, engineering and mathematics, she said. These students need to be prepared for college and the work force.

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Students place in regional science fair

PanGenX Takes Semantic-based Approach to Data Integration, Analytics for Personalized Medicine

By Uduak Grace Thomas

Bioinformatics startup PanGenX is betting that its semantic approach to data integration will ultimately help drug developers and diagnostic firms develop more personalized treatments.

The firm, based in Auburndale, Mass., intends to help pharma and diagnostic customers integrate proprietary and public data in "meaningful ways" and then run analyses that reveal information on individuals' responses to treatment, Jeremy Sohn, PanGenX's chief operating officer, explained to BioInform this week

The company markets the PanGenX Knowledge Base, which uses a linked data approach to aggregate pharmacogenetic data, results from peer-reviewed literature, health outcomes, and claims data. It relies on a set of proprietary ontologies that specify scientific, clinical, and business concepts and relationships to structure that data for querying and analysis.

Among the data included in the knowledgebase is a version of the National Center for Biotechnology Information's Single Nucleotide Polymorphism Database, or dbSNP, that improves on the publicly available resource, according to PanGenX.

The company's version, dubbed LD-SNP, offers a cleaner, normalized version of the public resource, which makes it possible to find additional variants that aren't currently associated with some genes in dbSNP, Sohn explained.

For example, he said, dbSNP's record of the DPYD gene which encodes for the dihydropyrimidine dehydrogenase enzyme that is involved in a metabolic pathway reports about 6,000 variants for the gene, while PanGenX's approach identified nearly 12,000 variants.

This data, combined with the company's semantic-based approach to analysis, makes it possible to map and compare polymorphisms between different individuals as well as calculate distributions of variants from a gene, drug, or disease perspective, PanGenX said.

The product also includes so-called PURL (Persistent Uniform Resource Locator) Nexus, or Plexus, technology, which lets the system combine data from the knowledgebase with remote customer data.

Currently, PanGenX offers two versions of its knowledgebase under a software-as-a-service business model: PanGenx-KB, priced at $250,000 per year for a site license, is geared toward pharma and diagnostic companies; while PanGenX-KB Professional, priced at $35,000 per year, is meant for academic and commercial research groups and labs.

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PanGenX Takes Semantic-based Approach to Data Integration, Analytics for Personalized Medicine

Neurology 'tsar' needed as services 'not up to scratch'

The report found that, while health spending on neurological conditions increased by 38 per cent in real terms, from 2.1 billion in 2006-7 to 2.9 billion in 2009-10, "spending on social services ... has remained flat".

Services for these people "remain well below the quality requirements set out" in the National Service Framework for Long-term Conditions, it noted.

It went on: "Unlike the Cancer and Stroke strategies the model used to implement the Framework has not worked.

"Implementation was left to local commissioners without the national leadership necessary to drive improvements."

Margaret Hodge, the Labour MP who chairs the committee, said: "The Cancer and Stroke strategies were headed by a Tsar and the Department monitored services with clear data against clear targets.

"For this clinical area, the Department left the implementation to local health commissioners but gave them no leadership at all."

She also said the Government "must set clear objectives" as the provision of health and social care became "decentralised" under its health reforms.

Paul Burstow, the Care Services Minister, said: "The Health and Social Care Bill offers a real opportunity to improve care and ensure people living with long-term neurological conditions get the best possible outcomes.

"It supports integration at every level to make sure people get the care and support they need at the right time and right place."

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Neurology 'tsar' needed as services 'not up to scratch'

Top Scientists from US, Canada, and Australia, Member of the Canadian Parliament and Stryker Executive to be Honored …

WEST HOLLYWWOOD, Calif., March16, 2012 /PRNewswire/ --Today, the Society for Brain Mapping & Therapeutics announced the 2012 recipients of the organization's prestigious Pioneers in Medicine, Technology, and Healthcare Policy Awards. The Society will honor each recipient at the Brain Mapping Foundation's Gala on June 1, 2012 as part of their 9th Annual World Congress in Toronto, Canada.

This year, the Society has selected Andres Lozano from the University of Toronto, Antonio Desalles from the University of California, Los Angeles and George Paxinos from the University of New South Wales to each receive a Pioneer in Medicine Award.The trio is on the forefront of Neuromodulation and Stereotactic-Radiosurgery. Their work has contributed to the understanding of the human brain and enabled scientists and surgeons across the globe to better treat neurological disorders such as Parkinson's Disease.

The Pioneer in Medicine Award is presented to individuals who have significantly contributed to scientific advancements in the fields of medicine and image guided therapy through a multi-disciplinary approach. Their groundbreaking contributions have led to the development of state-of- the-art technology.

George Paxinos has pioneered stereotaxic (3D) mapping in animal models, which enabled neuroscientists and neurosurgeons around the globe to learn more about the basic science of the brain and push conventional boundaries in clinical neuroscience. Antonio Desalles has contributed significantly to the frameless stereotactic radiosurgery technology and broken new grounds in the use of Deep Brain Stimulation (DBS) for treatment of Post Traumatic Stress Disorder (PTSD). Andres Lozano is highly regarded as one of the authorities in the field of DBS. He has broken new grounds in treatment of Depression, Obesity and Alzheimer Diseases using DBS.

"These scientists truly have advanced our understanding about the brain in a fundamental ways; their work has significantly contributed to introduction of new therapies for neurological disorders such as Parkinson's Disease, Depression and Post Traumatic Stress Disorders," states Babak Kateb, Founding Chairman of the Board of SBMT and President of Brain Mapping Foundation, and Director of National Center for Nano-Bio-Electronics, Research Scientist, Department of Neurosurgery, Cedars Sinai Medical Center, CA, USA.

The Pioneer in Healthcare Policy Award is presented to lawmakers who have demonstrated visionary policies laws that have contributed to the advancement of science, technology, education, and medicine. The past recipient of this prestigious award include Congresswoman Gabrielle Giffords (2011), Senator Harry Reid (2010), Senator Ted Kennedy and Madam Speaker Pelosi (2009) and Governor Schwarzenegger (2008).

This year Canadian MP, the Honorable Kirsty Duncan, will receive the Pioneer in Healthcare Policy Award for creating legislations, which has impacted research funding and better healthcare delivery in Canada. Her legislative work contributed significantly support for patients with neurological disorders in Canada and global collaboration in this area in order to expedite introduction of new therapies.

"Not only do her sound healthcare policies impact millions of people in Canada, they also provide a model for present and future generations. We are truly honored to recognize one of the best advocates of brain research in Canada," states Mike Chen, President of SBMT and Assistant Professor of Neurosurgery at City of Hope National Comprehensive Cancer Center, CA, USA.

Kevin Lobo, Orthopedics Group President from Stryker Corporation, will be accepting a Pioneer in Technology Development from the Society on behalf of the Stryker Corporation, which has contributed to introduction of new devices, technologies and significantly contributed to therapies of neurological disorders. The Pioneer in Technology Award is presented to trailblazing companies and their CEOs/presidents who have facilitated the development of pioneering technologies through interdisciplinary approaches that have impacted diagnostics, treatment, and healthcare delivery in unprecedented ways.

"The awards committee has been impressed with pioneering work done by Stryker Corporation to address health disparities. We hope Stryker continues its contribution to the field and support game-changing medical research with cutting edge technology that could one day turn into restorative solutions for patient with neurological disorders," said Shouleh Nikzad, member of the board of directors of SBMT and Brain Mapping Foundation, Co-chair of the Award Committee, and Lead, Advanced UV/Vis/NIR Detector Arrays and Imaging Systems, and Nanoscience Group, Strategic Initiative on Gigapixel Focal Plane Arrays, NASA/Jet Propulsion Laboratory, California Institute of Technology, CA, USA.

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Top Scientists from US, Canada, and Australia, Member of the Canadian Parliament and Stryker Executive to be Honored ...

Medical students find out residencies at Match Day

Twins William and Raphael "Rafi" Karkowsky have always shared life's best moments.

That was true again Friday when the brothers and best friends learned where they would begin their careers as doctors.

They were among nearly 16,000 medical students nationwide who opened Match Day letters and learned where they would conduct postgraduate study. More than 95 percent of students were matched with residency positions, the highest rate in 30 years, according to the National Resident Match Program.

The students enter medicine as health care reform could transform the industry and medical schools grapple with the expected shortage of doctors in years to come.

The brothers both wanted residencies in internal medicine, an increasingly popular choice among medical students, given the growing focus on primary care.

Raphael was on the phone with his girlfriend as he opened his letter among a small group of friends at the George Washington University School of Medicine and Health Sciences. He was matched in internal medicine with Thomas Jefferson University in Philadelphia, his third choice after Beth Israel Deaconess in Boston and Cornell University in New York.

"It was my favorite program, but not my top choice, so I'm actually happy with it, because the computer knew better than me where I should end up going," Rafi said. "It worked out for the best."

William took a deep breath before he and his wife, Hasya Pearlman, opened his letter together as his parents watched. The University of Maryland School of Medicine student was paired in internal medicine with the University of Chicago, his first choice. He beamed and kissed his wife repeatedly and seemed at a loss for words.

"I am pretty happy," he said later. "I got my first choice."

The 59-year-old Match Day program is designed as a fair way to assign students to residencies, where they will further their training for the next three to seven years.

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Medical students find out residencies at Match Day

Medical students matched with their residency programs, many to stay in La.

wwltv.com

Posted on March 16, 2012 at 5:54 PM

Meg Farris / Eyewitness News Email: mfarris@wwltv.com | Twitter: @megfarriswwl

NEWORLEANS - At the exact same time, at every medical school in the country, graduating seniors got an envelope announcing where they will spend the next five years of their lives training in an internship and residency program.

On Friday, graduates from LSU Medical School and Tulane Medical School each gathered at locations near the Morial Convention Center with their families to see if they got their first choices for the hospital and specialty they want to train in.

Amidst cheers from all the medical students, faculty doctors called out each student name by name.

One senior opened his envelope in front of our cameras, and saw he was going to Oregon.

"That was my first choice. I got my first choice for everything. So I've got to go talk to my family," he said running off in excitement.

At the LSU Medical School match, 108 out of 171 graduating seniors will stay in Louisiana to get their residency training. LSU doctors say the promise of a new teaching hospital is critical.

"It's just like a carpenter. You need a hammer and a nails to build a house. I need a first class hospital so these students can train and become the doctors that are going to take care of you and me," said Dr. Steve Nelson, Dean of the LSU Medical School.

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Medical students matched with their residency programs, many to stay in La.

Tufts Medical Students Match in Record-High Numbers in Family Medicine

Newswise BOSTON (March 16, 2012) Tufts University School of Medicine (TUSM) matched 22 medical school students, or 12% percent of its graduating class, to residency programs in family medicine. This is the largest number of matches ever in family medicine at Tufts, more than double the average percentage of the previous three years, and approximately four percentage points above the national average of students matching in family medicine.

Health-care reform is occurring at the fastest pace since the introduction of Medicare in the 1960s, and increasing the number of primary care physicians is key to achieving the nations goal of improving access to care, improving the nations health, and controlling health-care costs. The Association of American Medical Colleges Center for Workforce Studies predicts that there will be a shortage of 45,000 primary care physicians in the next decade. The Massachusetts Medical Societys 2011 Physician Workforce Study reported severe physician shortages in internal and family medicine, both primary care specialties, for the sixth consecutive year.

In response to the physician shortage, TUSM expanded its class size in 2009. That same year, TUSM partnered with Maine Medical Center on a program that provides students with experience in rural practice as well as training in a major tertiary medical center. Earlier this year, Tufts announced the launch of a new physician assistant, or physician-extender, program to assist physicians in providing access to care.

Another core step was redeveloping our curriculum to focus students on taking a patient-centered approach, a core value of primary care. In this patient-centered model, students begin interviewing patients in the community in their first week of medical school and progress on to a year-long apprenticeship with a primary care physician. This mentorship model introduces students to primary care earlier than most medical schools. Students are mentored by these faculty physicians, learn how to interact with patients, and obtain a first-hand experience in primary care, said Amy Kuhlik, MD, dean of students at TUSM.

In addition to the hands-on training in local communities, the curriculum changes also include a six-week rotation in family medicine for all students. Students train in doctors offices, community health centers, and academic teaching practices throughout New England. Students return to the classroom one day a week for innovative exercises such as interviewing patients with physical disabilities and patients on the autism spectrum and receiving direct feedback from those patients.

Students in the third year participate in workshops on health-care systems and reform; information mastery, or the art and science of efficiently accessing state-of-the-art and evidence-based information while caring for patients; treatment of underserved patients; physician wellness; and motivational interviewing, which involves coaching patients to discover their own motivations to make better decisions about their health, said Wayne Altman, MD, director of medical student education in the TUSM department of family medicine

Tufts students who choose family medicine are interested in making a difference in the communities that they serve and improving health-care outcomes in populations. Graduates from Tufts will attend some of the top programs in the country including our own Tufts Family Medicine program at Cambridge Health Alliance, which will help to address the physician shortage in Massachusetts, as well as at programs from Maine to California, said Randy Wertheimer, MD, Jaharis Chair of Family Medicine at Tufts University School of Medicine and Chief, Department of Family Medicine, at Cambridge Health Alliance.

The Tufts University Family Medicine Residency program at Cambridge Health Alliance, widely regarded as one of the best in the country, has pioneered a model program that relies less on training residents in hospitals and instead emphasizes outpatient training where family physicians are most apt to work.

The match, conducted annually by the National Resident Matching Program, matches medical school students with residency programs at US teaching hospitals.

# # #

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Tufts Medical Students Match in Record-High Numbers in Family Medicine

41 percent of local medical graduates to stay in Louisiana

In the annual ritual known as Match Day, when medical-school seniors find out where they will go for postgraduate training and, perhaps, the rest of their lives, 41 percent of the graduates of New Orleans' medical schools learned Friday that they will stay in Louisiana. At LSU School of Medicine, which accepts only Louisiana residents, 108 of the 171 seniors in the match -- 63 percent -- will go to residencies in New Orleans, LSU Health Sciences Center spokeswoman Leslie Capo said.

At Tulane University School of Medicine, which has no such entry requirement, 35 of the 177 students in the match -- about 20 percent -- learned that their residencies will be in Louisiana, Tulane spokesman Keith Brannon said.

At Louisiana's other medical, LSU School of Medicine in Shreveport, 49 of the 108 seniors in the match -- 45 percent -- will have Louisiana residencies, spokeswoman Meg Willett said.

In New Orleans, two hospitals offer residencies, even though they do not have medical school. Ochsner Medical Center filled all 55 of its slots, and East Jefferson General Hospital filled its seven positions, representatives of those institutions said.

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41 percent of local medical graduates to stay in Louisiana

UCSF Osher Center for Integrative Medicine – Video

13-03-2012 23:28 n existence for 12 years, the UCSF Osher Center for Integrative Medicine has become a premier integrative health resource for the San Francisco Bay Area and beyond. The first program of its kind to offer fully developed programs in research, education and patient care, the Osher Center is meeting the needs of patients who seek a healing-oriented approach to healthcare. To date, the Center has received two Center of Excellence Awards from the National Institute of Health; developed twenty-five hours of required curricula for medical, nursing and pharmacological students, and seen more than 20000 patient visits.

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UCSF Osher Center for Integrative Medicine - Video

My view: Gov. Herbert should veto sex-ed bill

Citizens rally in the rotunda of the Utah Capitol in Salt Lake City to ask Governor Herbert to veto HB363, Wednesday, March 14, 2012.

Ravell Call, Deseret News

Enlarge photo

As a lifelong resident of Utah, I am writing to express my concern over HB363 and am asking as a parent of teenage children that Gov. Gary Herbert please veto this sincere but misguided bill. For the past 15 years, I have taught courses on human development at a large private institution in Utah. I do not speak on behalf of my employer or its supporting institution, but as a private citizen and parent.

Part of the curriculum I teach is on human reproduction. Each semester, I take an informal survey asking how many students have talked with their parents about sex. Fewer than half of my students typically raise their hands. The reality is that many good families in Utah abdicate their role in teaching their children about sex, including the consequences and responsibilities associated with human sexuality.

My own parents waited until the night before my wedding to have a rather brief "talk" with me. While I appreciated their attempt, it came too late in my own development to help me through the confusing changes that coincide with adolescence.

Unfortunately, many youths are learning about sex from misinformed friends, media and other sources, including the Internet, where the dialogue is often devoid of any meaningful discussion about human relationships, birth control, sexually transmitted infections and the consequences of unplanned teen pregnancies. It is misguided to suggest that the absence of discussion about contraceptives, sexual intercourse and STIs in our schools is necessary or sufficient to deter kids from thinking about and engaging in sex.

A respectful dialogue on these matters may do more to appropriately encourage abstinence, especially when our children are well-informed and human sexuality is demystified for them. While it makes sense to encourage our youths to abstain, from a "public good" perspective, there is also compelling public good to arm our youths with accurate and complete information to help them make informed decisions regarding sex, especially when these decisions can have life-altering and generational consequences.

Research shows that what youth need to internalize behavioral standards is clear consistent messages coupled with adequate levels of information. This involves opportunities for a rational dialogue in which the individual child feels empowered to make informed decisions for himself or herself. Our schools are a safe place for such discussions to occur, especially in the absence of discussions in the home. An absence of any opportunity for respectful dialogue leaves open the possibility that our youth will be vulnerable to accepting the most persuasive messages they encounter, which today commonly comes in the form of popular media and friends.

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My view: Gov. Herbert should veto sex-ed bill

Genetic Engineering (excerpt) – Video

26-10-2011 07:18 Genetic engineering may be one of the greatest breakthroughs in recent history, however, with scientific advancements new ethical issues are raised, forcing us to ask not how, but if we should push genetic research to its absolute limit. This programme looks at the possible benefits of genetic engineering, such as the curing of hereditary diseases and the creation of better, more efficient crops. It also explores the potential issues that arise with this new technology - the questionable morality of cloning, and the controversy that surrounds stem-cell research are two topics which are also investigated. Students will hear both a secular and religious perspectives on the morality of intervening in nature at the most fundamental level. To find out more about this film, follow this link: http://www.classroomvideo.co.uk

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Genetic Engineering (excerpt) - Video

The Next Big Frontier?

At the Huffington Post's Science blog, Singularity University's Andrew Hessel says it's high time for a second Human Genome Project. "Today, in 2012, reading a human genome is no big deal," Hessel says. The next big frontier? "Genetic engineering," he adds.

Hessel proposes a challenge to the international research community:

I want to be absolutely clear that I'm talking only about the task of writing a complete 3 billion basepair human genome, correctly organized into 23 chromosomes, and packaged into a nucleus. A technical challenge, validated by showing the synthetic genome is functional if microinjected into a cultured cell. What I'm definitely not suggesting is growing a baby from a synthetic genome. Before we can fly, we need to be able to walk.

Hessel goes on to detail the reasons why writing a human genome is the next logical step in genomics, and suggests that "a coordinated effort to write a human genome would likely be completed in less than a decade, cost significantly less than the first HGP, and result in countless new biotech applications."

"It seems a no-brainer," he adds.

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The Next Big Frontier?

Stanford gene researchers see diabetes develop

A team of Stanford researchers has unveiled the most detailed biological profile of a human being done so far: a peek at one man's genetic foundation, along with snapshots, taken dozens of times over the course of a year, of the millions of proteins and other molecules that are in constant flux in his body.

In a stroke of shocking good luck - for the scientists, if not necessarily the patient - the profile subject developed Type 2 diabetes during the study, allowing researchers to follow in real time the molecular changes that took place as the illness progressed.

It also allowed the subject, Stanford geneticist Michael Snyder, to catch his diabetes early and stop it, most likely months or even years before he would have been diagnosed without the genetic profiling.

"This is the first time someone's actually analyzed the genome of a healthy person, predicted disease risk, and then by following him, actually saw a disease develop," said Snyder, who in addition to being the subject of the study was the senior author.

Snyder's profile and an analysis of the results were published today in the journal Cell. Snyder, chairman of the genetics department at Stanford, is not named in the published study because of privacy rules, but he volunteered to identify himself.

The research provides some of the first proof that detailed genetic profiling - beyond just DNA sequencing - could be used someday not just to predict an individual's chances of developing disease, but also to identify the smallest molecular changes that show when a person starts to become ill, said experts in personalized medicine.

The first human genome - a map of all of the DNA in a human cell - was announced in 2000. Seven or eight years later geneticists began mapping the genomes of specific individuals. Such personal genomic sequencing is expected to become widely available this year, at a cost of several thousand dollars.

Using genetic information to help diagnose and treat patients is still a very new field, although it's growing rapidly. Certain key genes have been found to greatly increase the risk of breast cancer, for example, or the deadly Huntington's disease, and doctors will regularly test for those genes when someone is diagnosed with an illness or when a close family member is known to have a disease.

But for most people, DNA sequencing and other biological profiling isn't yet useful - subjects would end up with a lot of unwieldy information that is mostly beyond modern scientific understanding or far too expensive to analyze.

"What they did (at Stanford) is much more interesting from a scientific basis than a practical basis," said Dr. David Witt, a medical geneticist at Kaiser San Jose. "And that gets to the heart of personalized medicine: It's not ready for prime time."

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Stanford gene researchers see diabetes develop

The computer knows its chemistry

Medicines are more and more often being developed by computer. This means chemists increasingly try out first of all on the screen something they afterwards replicate in actual practice in the laboratory. The computer acts as their playground and simulator, e.g. to find an active ingredient that binds perfectly to the specific structure of one of the bodys own proteins so it can suppress its activity, for example.

Whereas in the past chemists carried out such a computer-aided active ingredient search mainly by combing through data bases containing a limited number of candidate molecules to find which of them was most suitable, ETH Zurich researchers led by Gisbert Schneider, Professor at the Institute of Pharmaceutical Sciences, are now going one step further: they have developed a program that has memorised important rules of organic chemistry and can use it to build new active ingredient molecules from first principles. The researchers call it de-novo design.

Molecules never seen before

This has immensely expanded the possibilities for scientists searching for active ingredients. Practically all imaginable molecules are now available to the researchers as virtual candidate active ingredients. Schneider says, It gives us access to molecules that no chemist has ever synthesised or seen before.

Schneiders computer program can assemble molecules virtually on the modular principle and can compare them with existing molecules and calculate how well they fulfil the conditions defined by the researchers. The program can also modify molecules, thus gradually improving them in a process that resembles evolution, until finally the program delivers to the user the information about an optimised candidate active ingredient. To enable it to do this, the software knows a series of basic chemical modules and almost 60 of the most important reaction steps in organic chemistry. Schneider says, They are intentionally nowhere near all the reactions that exist. We have taught the program only the ones that are widely used by chemists and which in their experience also promise success.

The synthesis route is also taken into account

Schneider sees a big advantage in this, since comparable computer programs developed in the past 25 years sometimes produced random molecules irrespective of whether they were synthesizable at a reasonable cost. Because Schneiders program takes into account not only the finished molecule but also the route by which it could be synthesized in actual practice, it leads to active ingredients that really can also be prepared easily by laboratory synthesis.

The software has also passed its first practical test. Via the conventional computer-assisted method searching in a molecule data base - Schneiders work group found an active ingredient molecule that inhibits one of the bodys own enzymes involved in cell division. Thanks to the new software, they succeeded in finding another active ingredient with a structure completely different to the existing one. It has the same activity, but the advantage that it has not yet been patented. The aim is that one day they will be able to use this active ingredient in cancer therapy.

Also attractive for the industry

The search for active ingredients that have not yet been patented will then be an important area for the use of Schneiders software in the future as well. It is also important to find successor substances for medicines whose patent protection has expired.

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The computer knows its chemistry

The Greening of Chemistry

Newswise Cleaner! Faster! Cheaper! is a rallying cry for chemists working to limit the impact of their work on the environment.

Their efforts reflect the 12 guiding principles developed by chemists Paul Anastas and John Warner, who founded the green chemistry movement in the mid-1990s. Among the rules: Its better to prevent waste production than to clean it up afterward. But if there must be waste, it should be nontoxic or minimally poisonousas should the chemical products themselves. Chemical reactions should be energy efficient, for example by running at room temperature instead of being heated up. And ideally chemists should use renewable resources.

Chemistry may not be as obviously green as planting a tree, but researchers are working to make it better for the planet, one reaction at a time. Here are a few examples of how chemists funded by the National Institutes of Health are going green by improving the chemical processes used to make medicines, plastics and other products.

Water, Water Everywhere

If two chemicals are going to react, they usually need a liquid in which to do so. Often, thats a toxic solvent. When the reaction is over, the chemists have to dump the solvent or try to recycle it. A greener alternative is to start with a safer solventwater.

Bruce Lipshutz at the University of California, Santa Barbara, designed minuscule, bubble-like particles (nanoparticles) that shelter the reactions while surrounded by water. The chemicals go inside the particles, where they find the perfect environment to react together, and the product comes out. Because the reactions are so highly concentrated, they can happen at room temperature. Scientists dont have to kick-start the reactions using heat, saving time and energy.

Call in the Microbes

Another way to make reactions water-based, instead of solvent-based, is to recruit microbes to help reactions along. Scientists engineer microbes to make useful molecules, typically enzymes whose job is to carry out chemical reactions in water-based solutions. Chemists can use the microbes or the enzymes alone to speed up chemical reactions in a water solution.

For example, Jay Keasling at the University of California, Berkeley, is designing microbes to manufacture certain molecules. Several years ago, he inserted more than a dozen genes into Escherichia coli and yeast that enabled the organisms to churn out an antimalarial drug that is otherwise expensive to produce. Hes exploring a similar technique to generate HIV/AIDS drugs and environmentally friendly biofuels that might replace fossil-based fuels such as gasoline.

Shorter Syntheses

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The Greening of Chemistry

SHSU forensic chemistry student gets national prize

HUNTSVILLE Sam Houston State University forensic chemistry senior Brittany Winner, from Kingsville, is not only a winner in name, but also in deed as the recipient of the 2012 Society of Toxicology Pfizer Undergraduate Student Travel Award.

Pfizer selects five outstanding undergraduates in the nation each year who are presenting research at the organizations annual meeting to receive travel support and free registration for the meeting. This years conference is March 11-15 in San Francisco.

Awardees are selected based on the quality of a submitted poster abstract, personal statement, and an advisers supporting recommendation. The purpose of the award is to foster an interest in graduate studies in the field of toxicology.

Winner will have an opportunity to showcase her work along with a number of other students interested in toxicological research during the week. Winner researches the properties of cyanide and methods to encapsulate it in order to create an antidote against its deadly effects.

Her interest in toxicology and cyanide arose from a mentorship with Ilona Petrikovics, professor of chemistry and Sam Houston States expert on the studies of cyanide.

She talked about her work with cyanide in class, and I found it really interesting so I asked if I could be involved, said Winner. Petrikovicss research on cyanide is an ongoing project funded by the U.S. Governments Department of Defense. The study focuses on methods to dissipate its effects on the general population in case of cyanide use in bio-terrorism and/or poisoning.

During the mentorship, the relationship between Winner and Petrikovics developed into a strong partnership.

We had weekly lab meetings that lasted about an hour. Outside the lab Id also just drop by and wed talk. We talked about the research and other aspects of life, Winner said.

At the conference, Winner will be presented with a plaque for her accomplishments during an awards ceremony. The conference also provides a range of opportunities for companies to view and come into contact with different types of research and scholars.

Its a great place for networking, Winner said.

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SHSU forensic chemistry student gets national prize