Vitamin D deficiency unquestionably linked to bone fractures

Recent research from Scotland reinforces the longstanding medical opinion that vitamin D deficiency leads to a significantly increased risk of bone fractures.

Among people with hip fractures referred to the Scottish fracture liaison service, 98 percent test positive for serious deficiencies in vitamin D. Supplementation with the vitamin, on the other hand, significantly reduces the risk of repeat fractures.

"Taking a supplement can make a difference quite quickly," said Stephen Gallacher, head of the liaison service. "Bone density can increase by 20 percent in a few months with enough vitamin D."

"We have found we can reduce fractures by something like 30 to 50 percent. It is our belief that we can significantly reduce the risk of fractures in the population by giving people anti-osteoporosis therapy and vitamin D supplements."Read more...

Cardiofy Heart Care Supplement

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International Stem Cell's Q2 Revenues Nearly Triple by Deborah Sterescu

International Stem Cell Corporation (ISCO) (OTCBB:ISCO) reported Wednesday that second quarter sales more than doubled to almost triple, while year-to-date sales jumped a whopping 271%, as the company's operating subsidiaries continue to generate more revenue.
In addition to its hugely potentially valuable stem cell therapy business, the company also two other operations that have reflected revenue growth in the meantime, including Lifeline Cell Technology, which sells its cell-culture products to researchers to grow human cells for pre-clinical research, and Lifeline Skin Care, which sells skin care products based on its parent's stem cell technology.
For the three months ending June 30, International Stem Cell saw revenues rise to $1.1 million, from $0.44 million a year earlier.
Year-to-date revenues totaled $2.6 million, versus $0.7 million for the same period in 2010, helped by a $1.7 million contribution from Lifeline Skin Care, and a $0.9 million addition from Lifeline Cell.
In the last quarter, Lifeline Cell gained over 200 new customers due to new product introductions and the development of distribution channels internationally, a strategy ISCO plans to continue.
Meanwhile, the company's skin care business is coming off a highly successful launch at the end of last year, exceeding its plans to sell 1,000 products, with 7,000 products sold initially. Lifeline Skin plans to aggressively kick start major marketing initiatives again in September.
While these two subsidiaries are busy chalking up revenues, ISCO, whose parthenogenetic stem cell technology can be used to derive pluripotent stem cells, meaning they can be transformed into any cell type in the body, has many important advantages at its fingertips.
Regenerative medicine is a market that is set to boom in the coming years, as more and more companies are developing therapies based on stem cell use. International Stem Cell's long-term goal is to be a universal supplier of stem cells for not just one, but a host of therapies.
The company's parthenogenetic stem cells are derived from unfertilized eggs, avoiding the ethical issues behind the destruction of viable human embryos. Like embryonic stem cells, they also have the capacity to become almost any cell type in the body, but have demonstrated they are better in terms of the immune system, as one single stem cell line can be genetically matched to millions of people, reducing the need for immunosuppressants.
Its plan is to establish a US bank of its clinical-grade human parthenogenetic stem cells that will be capable of being immune-matched to millions of patients, so that a physician could call up and request a specific cell type for people. The company, which recently received approvals to enroll around 3 US donors for its bank, already has a collection of ten human parthenogenetic stem cell lines used for research purposes, which were derived outside the US.
These cell lines could potentially be used to cure a number of diseases, including cancer, heart disease, liver disease, among many others. Already, the company has several trials in the works, and has successfully demonstrated in pre-clinical animal studies that its stem cells can be used to create viable liver cells. It has also started pre-clinical animal trials to create neuronal cells in the brain, to potentially cure Parkinson's disease.
Unsurprisingly, all this work to progress the company's technology has increased expenses, contributing to a $2.5 million loss in the second quarter, or a 3 cent loss per share.
Research and development costs grew on account of greater scientific projects, while general and administrative costs leapt on increased headcount as the company bulks up its management team.
International Stem Cell, with $3.6 million in the bank at the end of the quarter, said that it has not ruled out future capital raising, but it already has a facility that allows it to draw equity as necessary to secure its planned growth.

Source:
http://intlstemcell.blogspot.com/feeds/posts/default?alt=rss

International Stem Cell’s Q2 Revenues Nearly Triple by Deborah Sterescu

International Stem Cell Corporation (ISCO) (OTCBB:ISCO) reported Wednesday that second quarter sales more than doubled to almost triple, while year-to-date sales jumped a whopping 271%, as the company's operating subsidiaries continue to generate more revenue.
In addition to its hugely potentially valuable stem cell therapy business, the company also two other operations that have reflected revenue growth in the meantime, including Lifeline Cell Technology, which sells its cell-culture products to researchers to grow human cells for pre-clinical research, and Lifeline Skin Care, which sells skin care products based on its parent's stem cell technology.
For the three months ending June 30, International Stem Cell saw revenues rise to $1.1 million, from $0.44 million a year earlier.
Year-to-date revenues totaled $2.6 million, versus $0.7 million for the same period in 2010, helped by a $1.7 million contribution from Lifeline Skin Care, and a $0.9 million addition from Lifeline Cell.
In the last quarter, Lifeline Cell gained over 200 new customers due to new product introductions and the development of distribution channels internationally, a strategy ISCO plans to continue.
Meanwhile, the company's skin care business is coming off a highly successful launch at the end of last year, exceeding its plans to sell 1,000 products, with 7,000 products sold initially. Lifeline Skin plans to aggressively kick start major marketing initiatives again in September.
While these two subsidiaries are busy chalking up revenues, ISCO, whose parthenogenetic stem cell technology can be used to derive pluripotent stem cells, meaning they can be transformed into any cell type in the body, has many important advantages at its fingertips.
Regenerative medicine is a market that is set to boom in the coming years, as more and more companies are developing therapies based on stem cell use. International Stem Cell's long-term goal is to be a universal supplier of stem cells for not just one, but a host of therapies.
The company's parthenogenetic stem cells are derived from unfertilized eggs, avoiding the ethical issues behind the destruction of viable human embryos. Like embryonic stem cells, they also have the capacity to become almost any cell type in the body, but have demonstrated they are better in terms of the immune system, as one single stem cell line can be genetically matched to millions of people, reducing the need for immunosuppressants.
Its plan is to establish a US bank of its clinical-grade human parthenogenetic stem cells that will be capable of being immune-matched to millions of patients, so that a physician could call up and request a specific cell type for people. The company, which recently received approvals to enroll around 3 US donors for its bank, already has a collection of ten human parthenogenetic stem cell lines used for research purposes, which were derived outside the US.
These cell lines could potentially be used to cure a number of diseases, including cancer, heart disease, liver disease, among many others. Already, the company has several trials in the works, and has successfully demonstrated in pre-clinical animal studies that its stem cells can be used to create viable liver cells. It has also started pre-clinical animal trials to create neuronal cells in the brain, to potentially cure Parkinson's disease.
Unsurprisingly, all this work to progress the company's technology has increased expenses, contributing to a $2.5 million loss in the second quarter, or a 3 cent loss per share.
Research and development costs grew on account of greater scientific projects, while general and administrative costs leapt on increased headcount as the company bulks up its management team.
International Stem Cell, with $3.6 million in the bank at the end of the quarter, said that it has not ruled out future capital raising, but it already has a facility that allows it to draw equity as necessary to secure its planned growth.

Source:
http://intlstemcell.blogspot.com/feeds/posts/default?alt=rss

Part 3: The Ellis Martin Report with Ken Aldrich of Int Stem Cell Corp (ISCO.OB)


Ellis Martin of The Ellis Martin Report interviews Ken Aldrich of International Stem Cell Corporation (ISCO.OB) on the latest research involving stem cell technology utilizing unfertilized eggs, as a basis for cell generation with a goal toward organ transplants which are immune to rejection by the body...as well as other applications. Mr. Aldrich also discusses neurological applications focusing on reversing Parkinson's disease. Preventing and reversing blindness is another topic covered. 


International Stem cell Corporation is a paid sponsor of The Ellis Martin Report

Source:
http://intlstemcell.blogspot.com/feeds/posts/default?alt=rss

Exercises to Avoid with Osteoarthritis of the Knee or Hip

Exercises to Avoid with Osteoarthritis of the Knee or Hip include:

- Running and jogging. The difference between how much force goes through your joints jogging or running, as opposed to with walking, is sometimes more than 10-fold your whole body weight

- Jumping rope
- High-impact aerobics
- Any activity where, at any time, you have both feet off the ground at once, however briefly (basketball, jumping)

Fortunately, that leaves a lot of activities that are OK for people with knee and hip osteoarthritis and that can help keep you mobile - see the list at WebMD.

References:

Image source: OpenClipart.org, public domain.

Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook.


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Can a Happy Relationship Predict a Happy Life? Apparently, Yes

The association between overall life satisfaction (LS) and relationship satisfaction (RS) was investigated longitudinally among 67,000 mothers in Norway.

Data were collected twice during pregnancy, and at 6 and 36 months postpartum:

- Satisfaction increased during pregnancy.
- However, relationship satisfaction decreased immediately following birth.
- Life satisfaction showed an initial increase followed by a decrease postpartum.

Relationship satisfaction predicted change in life satisfaction. Having a satisfying romantic relationship was important for retaining and increasing future life satisfaction.


References:

Can a Happy Relationship Predict a Happy Life? A Population-Based Study of Maternal Well-Being During the Life Transition of Pregnancy, Infancy, and Toddlerhood, Journal of Happiness Studies, Volume 11, 663-793, Number 6 / December 2010.

Image source: OpenClipArt.org, public domain.

Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook.


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Hepatitis C: Teenager Jazzy’s Story

NHS Choices: Teenager Jazzy was born with hepatitis C. This is her video diary about living with the condition.

Comments from Twitter:
@napernurse: Fortunate to live in UK where extensive med/psych prescriptions for HepatitisC covered by NHS. If liver transplant needed, that is covered too!

Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook.


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Porphyrias

From a Lancet review:

Hereditary porphyrias represent a group of 8 metabolic disorders of the haem biosynthesis. They are characterised by acute neurovisceral symptoms, skin lesions, or both.

Every porphyria is caused by abnormal function of a separate enzymatic step, resulting in a specific accumulation of haem precursors:

- 7 porphyrias are the result of a partial enzyme deficiency
- a gain of function mechanism is present in one new porphyria

Acute porphyrias present with acute attacks - severe abdominal pain, nausea, constipation, confusion, and seizure - and can be life-threatening.

Cutaneous porphyrias present with painful photosensitivity, skin fragility and blisters.

Porphyrias are still underdiagnosed. Screening of families to identify presymptomatic carriers and avoidance of precipitants is important.

References:

Porphyrias. The Lancet, Volume 375, Issue 9718, Pages 924 - 937, 13 March 2010.

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Patrick Ndungu talk at Drexel on Nanotechnology

One of my former Ph. D. students, Patrick Ndungu (now at University of KwaZulu Natal, South Africa) will be speaking at Drexel University on Friday August 19, 2011 at 12:30 in Disque 109.


Some Interesting Perspectives on the Integration of Nanomaterials with Energy and Water Treatment Technologies

As part of various key concerns in a developing economy, clean energy and access to potable water are an integral part of most strategic visions for sustainable socio-economic development. Of particular interest is the search for greener energy solutions that includes R&D into hydrogen energy technologies, and devices that utilize solar energy. Whilst clean water concerns centre on indigenous, cost-effective, and relatively simple technologies that can be easily deployed in remote or off-grid areas. Within this framework, this presentation will look at the evolution of a select body of work that has focused on the integration of carbon Nanomaterials into systems for hydrogen storage, fuel cells, and photo-catalytic materials for water treatment.

Source:
http://usefulchem.blogspot.com/feeds/posts/default?alt=rss

Google Apps Scripts Workshop at Drexel University

Andrew Lang will be in Philadelphia next week and we will be running a workshop on Leveraging Google Spreadsheets with Scripts for Research and Teaching. Now that our institution is no longer providing Microsoft Office for students in the fall term, it seems like a good time to explore converting some assignments and projects relying on Excel to freely available Google Spreadsheets. (Resources available here)

Andrew Lang (Department of Mathematics at Oral Roberts University) and Jean-Claude Bradley (Department of Chemistry at Drexel University) will host a workshop on Google Apps Scripts from 10:30 to 12:00 on Tuesday August 23, 2011 at the Hagerty Library in room L13C. They will demonstrate how users with no programming experience can easily add functions and drop-down menus to a Google Spreadsheet. Some chemistry examples will be detailed, such as inter-converting compound identifiers (common name, SMILES, CAS number, etc.) and reporting properties (melting points, solubility, density, etc.) with a single click. Participants are encouraged to suggest applications in other fields to explore during the workshop.

Source:
http://usefulchem.blogspot.com/feeds/posts/default?alt=rss

BrainCar by Olaf Mooij

Olaf Mooij brain car

Olaf Mooij brain car

Olaf Mooij brain car

Rotterdam-based artist, Olaf Mooij, known for his modifications of vehicles for the sake of art, created this brain car mash-up.  The brain captures video during the day and then remixes and projects the video on the inside of the brain at night, creating a somewhat psychedelic reflection of our own dreaming brains.

I love how the cerebellum becomes the trunk of the car.  Fantastic.

Does anyone know what type of car that is?

[spotted by SARO via Juxtapoz]

Source:
http://feeds.feedburner.com/streetanatomy/OQuC

Jumping Brain Goes XL Bronze

Emilio Garcias Jumping Brain goes XL Bronze

Emilio Garcias Jumping Brain goes XL Bronze

Freshly released from the amazing toy designer, Emilio Garcia:

LapoLab and Black Square Gallery present the first Bronze editions of EMILIO GARCIA XL Jumping Brain.

Fall 2011, Emilio Garcia will be presenting a Polished Bronze and a Black and Bronze version of its celebrated Jumping Brain, each will be a limited edition of 10 and is expected to cost $6,000 or 4,000€.

This XL piece weighs over 17Lbs and measures 8.5 x 17 x 13.3 inches and will be presented in a nice wooden box with. Black Square Gallery will be taking pre-orders for 5 of the 10 editions of each version. The rest will be exhibit at art fairs and art galleries in the US and Europe, and made available for collectors and visitors of this events.

If you are interested in pre-ordering any of it, please email ron@blacksquaregallery.com or contact@emiliogarcia.org

A 17 pound brain!  Mighty impressive.

 

Source:
http://feeds.feedburner.com/streetanatomy/OQuC

Seoul, Korea

















Hi all. My sincere apologies for falling behind on Morbid Anatomy. I am currently living in Seoul, Korea as part of the very generous Apex Art Outbound Residency Program (thanks, Josh Foer!), and one of the obligations of the residency is to blog about my experiences. Sadly, this had taken my focus off Morbid Anatomy a bit.

I promise to do my best over this next month in Korea to get some Morbid Anatomy reportage done; in the meantime, if you are curious about what I am finding in Seoul, you can check out my Apex Art blog here.

Thanks for your patience, and I will be back in full force in mid-September!

Source:
http://morbidanatomy.blogspot.com/feeds/posts/default?alt=rss

Functional characterization of cellulases identified from the cow rumen fungus neocallimastix patriciarum W5 by transcriptomic and secretomic analyses

Background:
Neocallimastix patriciarum is one of the common anaerobic fungi in the digestive tract of ruminants that can actively digest cellulosic materials and its cellulases are of great potential for hydrolyzing cellulosic feedstocks. Due to the difficulty in culture and lack of a genome database, it is not easy to gain a global understanding of the glycosyl hydrolases (GHs) produced by this anaerobic fungus.
Results:
We have developed an efficient platform that uses a combination of transcriptomic and proteomic approaches on N. patriciarum to accelerate gene identification, enzyme classification, and application in rice straw degradation. By complementary studies of transcriptome (Roche 454 GS and Illumina GA IIx) and secretome (ESI-Trap LC-MS/MS), we identified 219 putative glycosyl hydrolase (GH) contigs and classified them into 25 GH families. The secretome analysis identified four major enzymes involved in rice straw degradation: beta-glucosidase, endo-1,4-beta-xylanase, xylanase B and Cel48A exo-glucanase. From the sequences of assembled contigs we cloned 19 putative cellulase genes, including GH1, GH3, GH5, GH6, GH9, GH18, GH43 and GH48 gene families, which were highly expressed in N. patriciarum cultures grown on different feedstocks.
Conclusions:
These GH genes were expressed in Pichia pastoris and/or Saccharomyces cerevisiae for functional characterization. At least five novel cellulases displayed cellulytic activity for glucose production. One beta-glucosidases (W5-16143) and one exo-cellulase (W5-CAT26) showed strong activities and could potentially be developed into commercial enzymes.Keywordsanaerobic fungi, biomass, rice straw, sugarcane, napiergrass, GH, next-generation sequencingSource:
http://www.biotechnologyforbiofuels.com/rss/

Vitamin D deficiency unquestionably linked to bone fractures

Recent research from Scotland reinforces the longstanding medical opinion that vitamin D deficiency leads to a significantly increased risk of bone fractures.

Among people with hip fractures referred to the Scottish fracture liaison service, 98 percent test positive for serious deficiencies in vitamin D. Supplementation with the vitamin, on the other hand, significantly reduces the risk of repeat fractures.

"Taking a supplement can make a difference quite quickly," said Stephen Gallacher, head of the liaison service. "Bone density can increase by 20 percent in a few months with enough vitamin D."

"We have found we can reduce fractures by something like 30 to 50 percent. It is our belief that we can significantly reduce the risk of fractures in the population by giving people anti-osteoporosis therapy and vitamin D supplements."Read more...

Cardiofy Heart Care Supplement

Source:
http://feeds.feedburner.com/integratedmedicine

Defining infertility–a systematic review of prevalence studies

BACKGROUND

Existing definitions of infertility lack uniformity, rendering comparisons in prevalence between countries or over time problematic. The absence of an agreed definition also compromises clinical management and undermines the impact of research findings. The aim of this study was to perform a systematic review of the literature to determine how infertility has been defined in prevalence studies and to come up with suggestions for a feasible and clinically relevant definition.

METHODS

MEDLINE, EMBASE, CINAHL and Cochrane Database of Systematic Reviews were searched for relevant population-based prevalence studies published between 1975 and 2010.

RESULTS

A total of 39 articles were included in the current review. The results highlight the heterogeneity of criteria used to define infertility and critical differences between demographic and epidemiological definitions. Demographers tend to define infertility as childlessness in a population of women of reproductive age, while the epidemiological definition is based on ‘trying for’ or ‘time to’ a pregnancy, generally in a population of women exposed to the risk of conception. There is considerable variation in terms of the duration of ‘trying for pregnancy’, the age of women sampled and their marital or cohabitation status. This leads to inconsistencies in determining the numerator and denominator used to calculate the prevalence of infertility.

CONCLUSIONS

There is a need for an agreed definition for infertility. We suggest a clinically relevant definition based on the duration of trying for pregnancy coupled with female age.

Source:
http://humupd.oxfordjournals.org/rss/current.xml

Maternal smoking in pregnancy and birth defects: a systematic review based on 173 687 malformed cases and 11.7 million controls

BACKGROUND

There is uncertainty over whether maternal smoking is associated with birth defects. We conducted the first ever comprehensive systematic review to establish which specific malformations are associated with smoking.

METHODS

Observational studies published 1959–2010 were identified (Medline), and included if they reported the odds ratio (OR) for having a non-chromosomal birth defect among women who smoked during pregnancy compared with non-smokers. ORs adjusted for potential confounders were extracted (e.g. maternal age and alcohol), otherwise unadjusted estimates were used. One hundred and seventy-two articles were used in the meta-analyses: a total of 173 687 malformed cases and 11 674 332 unaffected controls.

RESULTS

Significant positive associations with maternal smoking were found for: cardiovascular/heart defects [OR 1.09, 95% confidence interval (CI) 1.02–1.17]; musculoskeletal defects (OR 1.16, 95% CI 1.05–1.27); limb reduction defects (OR 1.26, 95% CI 1.15–1.39); missing/extra digits (OR 1.18, 95% CI 0.99–1.41); clubfoot (OR 1.28, 95% CI 1.10–1.47); craniosynostosis (OR 1.33, 95% CI 1.03–1.73); facial defects (OR 1.19, 95% CI 1.06–1.35); eye defects (OR 1.25, 95% CI 1.11–1.40); orofacial clefts (OR 1.28, 95% CI 1.20–1.36); gastrointestinal defects (OR 1.27, 95% CI 1.18–1.36); gastroschisis (OR 1.50, 95% CI 1.28–1.76); anal atresia (OR 1.20, 95% CI 1.06–1.36); hernia (OR 1.40, 95% CI 1.23–1.59); and undescended testes (OR 1.13, 95% CI 1.02–1.25). There was a reduced risk for hypospadias (OR 0.90, 95% CI 0.85–0.95) and skin defects (OR 0.82, 0.75–0.89). For all defects combined the OR was 1.01 (0.96–1.07), due to including defects with a reduced risk and those with no association (including chromosomal defects).

CONCLUSIONS

Birth defects that are positively associated with maternal smoking should now be included in public health educational materials to encourage more women to quit before or during pregnancy.

Source:
http://humupd.oxfordjournals.org/rss/current.xml