Monthly Archives: May 2011

Merits of the Gung Ho Argument for Immortality

Posted on by

I don't see anything wrong with standing up and arguing passionately for the merits of either immortality as a Platonic ideal or immortality as a practical goal. Here I take the colloquial modern meaning of agelessness attained through biotechnology rather than the old-school "never die, ever" variety of immortality attained only in stories and myths. But someone has to be out there pushing out the boundaries of the discussion:

The middle of the road, "reasonable" position in public or political debate tends to gravitate to midway between what are perceived to be the two opposite outrageous extremes, regardless of the actual merits of any of these positions. With this in mind, it is occurring to me that part of the ongoing problem in the modern political debate over healthy life extension is that our "outrageous extreme" has always been a tentative, reasonably proposal that medical research carry on and that near-term technology would seem to allow us all to live a little longer ... say, to 150.

Public discourse is an arena of the timid, people who build their own cage of narrow visions and incremental goals. Without loud visionaries coming along to rattle the bars and point to the mountains in the distance, nothing would ever get done. Live to 150? Peanuts. If we enacted the goals of SENS, producing a rejuvenation biotechnology toolkit to repair the biochemical damage of aging, we'd all live for thousands of years if the present rate of fatal accidents continued as-is.

So I'm always pleased to see people putting out opinions like this and provoking resulting discussions like this one at Hacker News:

I want to live forever. I've always thought that not dying was a pretty obvious thing to want. To my surprise, I've found that a lot of people whom I usually agree with on most topics strongly disagree with me on this one. Rather than write yet another piece extolling the virtues of a far-future post-scarcity post-singularity world, I thought I'd just document some of the objections to immortality I get and my counterarguments.

Note that for the purposes of giving my conversational partners opportunities to disagree, I typically posit a form of immortality where you, and you alone are presented with the option of eternal youth with no suicide option. You constantly regenerate to perfect health at the prime of your life. There are a lot of potential ways we might go about not dying, but people tend to find objections to this particular flavor more readily than the others. Please assume this working definition for the below.

Even discussion of the platonic ideal of immortality is, I think, useful provocation against the backdrop of advancing biotechnology that will be able to extend the human lifespan significantly in decades to come. Those advances won't happen by themselves: people need to work on them, support them, and demand them. An economy of longevity-enhancing biotechnology must arise, and for that there needs to be - at a minimum - a whole lot more people talking and thinking about the prospects.

I believe in Renewable Energy, and here’s why

Posted on by

Renewable energy (RE) is a subjective and divisive topic, one that is influenced by many factors, including corruption, greed and purposeful ignorance, scientific and technological advances, and simple entrepreneurial spirit vs. entrenched interests.

Here are some of the reasons that I believe that we will see RE replace old energy by the midpoint of this century:

* It has been estimated that an area 55 miles by 55 miles dedicated to current solar technologies could replace all the electrical generating power of coal and oil (in the US). Or an area 80x80 miles to replace oil, coal and natural gas. (Here in the US we have over 100,000 square miles of desert, so space isn’t a problem)

* Regarding storage technologies (1) for when the sun is down: consider the advances taking place in fuel cells, batteries (LI, redox flow batteries, and 1300-ton battery modules used for grid stabilization), flywheels, compressed air, ultracapacitors and the likelihood that we will also use battery powered vehicles as storage.

* Regarding “getting the power from the solar installation to the people” – consider advances in superconducting wire and other advanced materials which are very likely to enable cheap and efficient transmission of power from where ever it is generated to where ever it is needed.

* Rooftop and local solar: My solar powered home won’t have to worry about darkness; we’ll tap into the battery reserve, as will all rooftop solar installations. A small percentage of our overall use to be sure, but significant none the less.

And as for explicit subsidies: on a per-energy-unit basis, then yes, solar has received more subsidies than fossil fuels in the very recent past. However, on the amount that each of us taxpayers has spent in a recent five-year period, fossil fuels subsidies far exceed solar.

Estimates range: (2)

Coal subsidies = somewhere between $17B and $72B
Solar subsidies = somewhere between $500M and $5B

And let us not forget that coal subsidizes also include intangible (and often purposefully left out) costs for cleaning up the ecosystem, and the public health expenses associated with all of the damage that the mining and use of coal causes. (3)

In my opinion, at the end of the day it all boils down to two simple facts: 1) technological change is on a double exponential growth curve (4) and 2) simple entrepreneurial spirit.

While we certainly need to wean society off finite, dangerous, polluting resources like coal and oil, the earth can and may go to hell in a handbasket. However, I think that entrepreneurial spirit and the certain fact that there is a barrel of money to be made in renewable energy solutions suggests that we will see RE replace old energy by the midpoint of this century. (5)

(1) "Of the ten advanced energy storage technologies, eight have applications in storage for electric power utilities at some level of development, aiming to provide reliable, economic, and energy-efficient power back-up options." Technical Insights Analyst Miriam Nagel

A123 Systems currently sells 2MW to 200MW grid stabilization systems (battery systems). Being used for large-scale energy storage deployment to support wind and solar integration. Small in comparison to the overall needs, but just one of many rapidly improving technologies.

“If investments in the smart grid infrastructure continue, electric vehicles may become ubiquitous — both because of the economic and environmental sense they make for consumers, and because of the vast store of batteries that will be available to grid operators to balance out the intermittency of wind and solar resources.”

“There are several major studies and research showing how the United States could reach 100 percent renewable electricity by 2050. Over the next two decades, the continually rising costs of fossil fuels will make it prohibitive to continue burning them, so we’ll witness the overdue transition to a largely renewable system. Smart grid upgrades will feature two-way communication to consumer appliances, real-time pricing information, more efficient transmission infrastructure, and advanced battery and flywheel technologies to balance the inherent fluctuations of wind and solar resources.”

http://www.mnn.com/earth-matters/energy/blogs/quayle-hodek-a-young-ceo-running-with-the-wind?hpt=Sbin

(2) “What if solar got the same subsidies as coal?” (Oct 21, 2010)
http://cleantechnica.com/2010/10/21/what-if-solar-got-the-same-subsidies-as-coal/

Coal subsidies: The U.S. coal industry enjoyed subsidies of around $17 billion between 2002 and 2008, including tax credits for production of "nonconventional" fuels ($14.1 billion), tax breaks on coal royalties ($986 million), exploration, and development breaks ($342 million), according to a study by the Environmental Law Institute.

http://sierraclub.typepad.com/mrgreen/2010/03/does-the-coal-industry-get-subsidies.html

Solar and wind subsidies: So far, the government has handed out about $5.4 billion, according to the Energy Department.

http://money.cnn.com/2010/11/18/news/economy/renewable_energy_tax_credit/index.htm

(3) Very informative investigative article http://wonkroom.thinkprogress.org/2011/02/03/manchin-coal-subsidies/

(4) “Most long range forecasts of technical feasibility in future time periods dramatically underestimate the power of future technology because they are based on what I call the “intuitive linear” view of technological progress rather than the “historical exponential view.” To express this another way, it is not the case that we will experience a hundred years of progress in the twenty-first century; rather we will witness on the order of twenty thousand years of progress (at today’s rate of progress, that is).” Ray Kurzweil http://www.kurzweilai.net/the-law-of-accelerating-returns

(5) During the past 11 years, as the editor of the leading nanoscale technologies web portal, I read and posted over 50,000 articles about advanced and frequently mind-blowing technologies. I have closely followed the very rapid progress in our understanding and utilization of the unique properties of the nanoscale (which greatly differ from the properties that we already understand). At the very least, we are headed for a future that not one of us can predict; what we can predict is that we will undoubtedly see old myths about technologies shattered and changes beyond our current level of comprehension.

I believe in Renewable Energy, and here's why

Posted on by

Renewable energy (RE) is a subjective and divisive topic, one that is influenced by many factors, including corruption, greed and purposeful ignorance, scientific and technological advances, and simple entrepreneurial spirit vs. entrenched interests.

Here are some of the reasons that I believe that we will see RE replace old energy by the midpoint of this century:

* It has been estimated that an area 55 miles by 55 miles dedicated to current solar technologies could replace all the electrical generating power of coal and oil (in the US). Or an area 80x80 miles to replace oil, coal and natural gas. (Here in the US we have over 100,000 square miles of desert, so space isn’t a problem)

* Regarding storage technologies (1) for when the sun is down: consider the advances taking place in fuel cells, batteries (LI, redox flow batteries, and 1300-ton battery modules used for grid stabilization), flywheels, compressed air, ultracapacitors and the likelihood that we will also use battery powered vehicles as storage.

* Regarding “getting the power from the solar installation to the people” – consider advances in superconducting wire and other advanced materials which are very likely to enable cheap and efficient transmission of power from where ever it is generated to where ever it is needed.

* Rooftop and local solar: My solar powered home won’t have to worry about darkness; we’ll tap into the battery reserve, as will all rooftop solar installations. A small percentage of our overall use to be sure, but significant none the less.

And as for explicit subsidies: on a per-energy-unit basis, then yes, solar has received more subsidies than fossil fuels in the very recent past. However, on the amount that each of us taxpayers has spent in a recent five-year period, fossil fuels subsidies far exceed solar.

Estimates range: (2)

Coal subsidies = somewhere between $17B and $72B
Solar subsidies = somewhere between $500M and $5B

And let us not forget that coal subsidizes also include intangible (and often purposefully left out) costs for cleaning up the ecosystem, and the public health expenses associated with all of the damage that the mining and use of coal causes. (3)

In my opinion, at the end of the day it all boils down to two simple facts: 1) technological change is on a double exponential growth curve (4) and 2) simple entrepreneurial spirit.

While we certainly need to wean society off finite, dangerous, polluting resources like coal and oil, the earth can and may go to hell in a handbasket. However, I think that entrepreneurial spirit and the certain fact that there is a barrel of money to be made in renewable energy solutions suggests that we will see RE replace old energy by the midpoint of this century. (5)

(1) "Of the ten advanced energy storage technologies, eight have applications in storage for electric power utilities at some level of development, aiming to provide reliable, economic, and energy-efficient power back-up options." Technical Insights Analyst Miriam Nagel

A123 Systems currently sells 2MW to 200MW grid stabilization systems (battery systems). Being used for large-scale energy storage deployment to support wind and solar integration. Small in comparison to the overall needs, but just one of many rapidly improving technologies.

“If investments in the smart grid infrastructure continue, electric vehicles may become ubiquitous — both because of the economic and environmental sense they make for consumers, and because of the vast store of batteries that will be available to grid operators to balance out the intermittency of wind and solar resources.”

“There are several major studies and research showing how the United States could reach 100 percent renewable electricity by 2050. Over the next two decades, the continually rising costs of fossil fuels will make it prohibitive to continue burning them, so we’ll witness the overdue transition to a largely renewable system. Smart grid upgrades will feature two-way communication to consumer appliances, real-time pricing information, more efficient transmission infrastructure, and advanced battery and flywheel technologies to balance the inherent fluctuations of wind and solar resources.”

http://www.mnn.com/earth-matters/energy/blogs/quayle-hodek-a-young-ceo-running-with-the-wind?hpt=Sbin

(2) “What if solar got the same subsidies as coal?” (Oct 21, 2010)
http://cleantechnica.com/2010/10/21/what-if-solar-got-the-same-subsidies-as-coal/

Coal subsidies: The U.S. coal industry enjoyed subsidies of around $17 billion between 2002 and 2008, including tax credits for production of "nonconventional" fuels ($14.1 billion), tax breaks on coal royalties ($986 million), exploration, and development breaks ($342 million), according to a study by the Environmental Law Institute.

http://sierraclub.typepad.com/mrgreen/2010/03/does-the-coal-industry-get-subsidies.html

Solar and wind subsidies: So far, the government has handed out about $5.4 billion, according to the Energy Department.

http://money.cnn.com/2010/11/18/news/economy/renewable_energy_tax_credit/index.htm

(3) Very informative investigative article http://wonkroom.thinkprogress.org/2011/02/03/manchin-coal-subsidies/

(4) “Most long range forecasts of technical feasibility in future time periods dramatically underestimate the power of future technology because they are based on what I call the “intuitive linear” view of technological progress rather than the “historical exponential view.” To express this another way, it is not the case that we will experience a hundred years of progress in the twenty-first century; rather we will witness on the order of twenty thousand years of progress (at today’s rate of progress, that is).” Ray Kurzweil http://www.kurzweilai.net/the-law-of-accelerating-returns

(5) During the past 11 years, as the editor of the leading nanoscale technologies web portal, I read and posted over 50,000 articles about advanced and frequently mind-blowing technologies. I have closely followed the very rapid progress in our understanding and utilization of the unique properties of the nanoscale (which greatly differ from the properties that we already understand). At the very least, we are headed for a future that not one of us can predict; what we can predict is that we will undoubtedly see old myths about technologies shattered and changes beyond our current level of comprehension.

International Stem Cell Corporation Chairman Presents Summary of Achievements at Annual Shareholders’ Meeting

Posted on by

CARLSBAD, Calif. (May 05, 2011) - At the annual shareholders meeting of International Stem Cell Corporation (OTCBB:ISCO) on May 3, 2011, Kenneth Aldrich, Chairman and co-founder of ISCO conducted a presentation to shareholders that included the following remarks:

Good morning to all our shareholders and friends of ISCO. Let me make just a few comments about where we are and the progress we have made over the last year. All of the developments and news I will discuss were announced in the past 12 months, but with the passage of time it is easy to lose track of how much progress ISCO has actually made. I won’t mention everything—we don’t have that much time, but some highlights will, I hope, help put these recent achievements into perspective.

A little less than a year ago, in June 2010, our first parthenogenetic patent application was formally approved by the US Patent Office. More applications are pending, but this approval established ISCO as the lawful owner of the rights to produce human stem cell lines through parthenogenesis. That is a platform on which we expect to build for a long time.

Also in June we eliminated all of our outstanding corporate debt and we remain debt free.

In July we announced the signing of a distribution contract with Sristi Biosciences, a major seller of research products in India, which continues the international commercial expansion of our Lifeline Cell Technology® brand.

In October we announced the first steps toward the formation of a major funded collaboration in India with Insight Bioventures India Private Limited (IBVI) to develop treatments for corneal damage and retinal disease. Planning for that work is ongoing and the Executive Director of Insight Bioventures has flown in from India to meet with us today, so we remain very optimistic about this project.

In November, we presented the results of scientific studies demonstrating a new and better method for differentiating our parthenogenetic cells into liver cells, a critical step toward using them to treat liver disease.

In November and December we launched the first test marketing runs of our new skin crème products, first to our own shareholders and friends, then to a select mailing list developed by our marketing partner, John Mauldin. Those resulted in sales of over 7,000 bottles of our new products.

In December we established $25 million financing commitment that provides access to capital on an as-needed basis over a three year period, but never requires the sale of stock unless we think it will benefit the company and its shareholders. This agreement provides us a high degree of flexibility in meeting our financial needs.

In January 2011 we announced publication of peer-reviewed studies further validating the functional equivalency of our parthenogenetic stem cells with embryonic stem cells. These studies confirm our ability to benefit from much of the millions of dollars of research on embryonic stem cells over the last decade. In short, we have a running start in the search for cures.

Throughout the year we have made steady progress in development of liver cells and liver precursor cells, culminating in an announcement in April of this year that we had successfully completed the first in a series of pre-clinical tests of parthenogenetically derived liver cells.

Last, but by no means least, we have received the necessary approvals for creating new Parthenogenetic Stem Cell Lines in the United States. These will be clinical grade lines suitable for human trials, and are the first major step in this country to begin building a “Bank” of stem cells enabling the matching of immune systems of millions of people worldwide, with the potential to eliminate or reduce the harmful effects of immune suppressing drugs that would normally have to be used with stem cell transplant procedures.

All of these news stories and more are available on our website along with presentations we have made recently to investors in the US and Europe. On behalf of the Board of Directors and everyone at ISCO, I thank you for your support.

About International Stem Cell Corporation

International Stem Cell Corporation is focused on the therapeutic applications of human parthenogenetic stem cells and the development and commercialization of cell-based research and cosmetic products. ISCO's core technology, parthenogenesis, results in the creation of pluripotent human stem cells from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing genders, ages and racial background. This offers the potential to create the first true stem cell bank, UniStemCell™. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology, and cell-based skin care products through its subsidiary Lifeline Skin Care. More information is available at http://www.internationalstemcell.com.

To subscribe to receive ongoing corporate communications, please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

Forward-looking Statements

Statements pertaining to anticipated developments, product introduction plans and related support, the potential benefits of products, and other opportunities for the company and its subsidiaries, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates,") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products and the management of collaborations, regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update forward-looking statements.

Contact:

International Stem Cell Corporation

Kenneth C Aldrich, Chairman

760-940-6383

kaldrich@intlstemcell.com

# # #

For doctors: How to be a Twitter star in two easy steps

Posted on by

Warning: The purpose of this article is to inspire you to use Twitter, not to scare you. There are plenty of other blog posts and newspaper articles about doctors posting pictures of body parts on Facebook and getting fired. This is not it. Social media is amazingly useful for doctors and patients if you use the tools responsibly, have common sense, and never share the 18 HIPAA identifiers online or offline with unauthorized parties. The advice below is derived from extensive personal experience. I have used social media for professional purposes, as a physician, for more than 7 years, while working at some of the leading institutions in the U.S. such as the Cleveland Clinic and the University of Chicago. My account @DrVes has just been ranked #6 on the list of the Most Influential People from Chicago on Twitter (selected by Chicago Tribune and Klout.com). My blog websites have had more than 7 million page views. Just as an example, every time I hit the "publish" button of the sites, the message reaches more than 25,000 people every single day: 15,700 RSS and email subscribers, 7,000 Twitter followers, 2,200 daily visitors, and 1,000 Facebook fans (statistics for the sites ClinicalCases.org and CasesBlog, AllergyCases.org and AllergyNotes, and the Twitter accounts @DrVes and @Allergy).

This is somewhat of a typical example nowadays. There are many other physicians who are much more popular than me on social media and make the stats above look minuscule. You can be one of them. Here is how.

The basics of Twitter use for busy doctors

Most doctors are really busy. Several questions always come up when doctors consider the use of social media for professional purposes: Who has time for Twitter? What am I going to say there? To whom? And why Twitter, to begin with? What about Facebook or YouTube? My office is a mess and I always say "ehhh" when recorded -- I don't want to do video. Do I need a blog too?

Good questions. Here are the answers.
The circle of online information for me is as follows: Google Reader -> Share on Twitter -> Get feedback -> Write a blog post -> Share via RSS and Twitter -> Get feedback, go on. You don't need to use all services.


The circle of online information (full version) (click to enlarge).

1. Who has time for Twitter?

You do. Twitter should take no more 30 minutes per day and it will be beneficial for you, your colleagues and your patients. You will learn more and will feel better about it. Make it part of your normal routine - just like checking the news. In fact, Twitter is just that - checking the news - and then sharing the ones that you find most interesting with your followers. This takes a single click, and 2 seconds. Ten tweets per day, 2 seconds each. This is 20 seconds. You can do it.

2. Why Twitter?

Start on Twitter because it is quick and relatively easy. Twitter has the lowest barrier to entry among all social media services. "Being on Twitter" requires just 10 short sentences per day, with approximately 7 words each. You can reach thousands of people with a single sentence. Would you like to share the latest guidelines for food allergy? Just click and all your Twitter followers will know about them instantly. You will also get feedback to your tweets via replies and re-tweets.

3. What am I going to say on Twitter?

The answer is simple. You are an expert. There is a flood of medical news that hits the wires every day. I want to know what YOU think is important. Share the 3-10 news items per day that you find interesting. I will subscribe to read them. Many will do the same.

4. Who is going to read my tweets?

As a physician, you are an expert in your field. You provide valuable insight - just be selecting what you think it’s important from the news of the day. Embed this little personal news stream in your practice page. Your patients will appreciate the helpful updates, hand-picked by their doctor. Your colleagues may find it interesting too.

5. What about Facebook or YouTube?

Those are nice but I would start on Twitter first, and then expand if you see the need to do so. It may be a good idea to start a like/fan page on Facebook for your practice and re-post some of the tweets there. This is simple and not time-consuming. It can be done automatically.

6. Do I need a blog too?

Only you can tell if you need a blog. If you feel that you need to expand beyond 7-8 words on Twitter, by all means, start a free blog on Blogger.com by Google or WordPress.com and see how that works for you. Start on Twitter and expand to a blog as a natural extension if you need to write longer or provide some background. Post your blog items in your Twitter feed.

How to be a Twitter "star" in two easy steps

This is easy. It’s a two-step process for beginners and it takes about 30 minutes per day. The best time is just after your kids go to sleep.

1. Review the news of the day from Google Reader. I have ready-made subscription RSS bundles for you below. Alternatively, you can check a service such as Webicina.com for RSS feeds in your specialty.

2. Post the news items that you like best on Twitter. Don’t post all 10 tweets at once. Schedule them evenly throughout the next day. The first tweet goes on at 7:30 am EST and the last one at 8:30 pm EST. You can use Seesmic Web to schedule tweets - it is simple, free, and just works. The alternatives include HootSuite and any number of scheduling services (some of them have a limitation of up to 10 tweets per day).

This summary did no address the other Twitter activities such as listening, engaging, search, chat, HIPAA compliance, etc. They will be discussed in future articles.

RSS bundles of medical news

You can use the following RSS bundles to subscribe to medical news items. The bundles are exported from my personal Google Reader page. They update automatically several times per day. When in Google Reader, just select the ones that you find interesting and share them on Twitter. Feel free to add your own comments to some of the tweets.

Top Twitter Doctors

This is a list of the Top Twitter Doctors arranged by specialty in alphabetical order - feel free to add your own suggestions. The list is open to anybody to edit:

Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook.


Video: Teens See Dangers of Texting While Driving

Posted on by

AssociatedPress — May 16, 2010 — Teenagers are driving through an obstacle course with their cell phones in hand to see why texting while driving is so dangerous.

Related:
Proposal: All cell phones sold in Chicago to allow parents to block their children from texting while driving. Chicago Tribune, 2011.

Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook.


Postural Orthostatic Tachycardia Syndrome (POTS) – Mayo Clinic video

Posted on by

Phil Fischer, M.D., discusses the latest research on Postural Orthostatic Tachycardia Syndrome (POTS).

Two free full text reviews are available via Dr. RW Notes.
Comments from Twitter:
@drjohnm (John Mandrola, MD): For EPs, POTS is one tough nut to crack.>>Helpful video.

Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook.


Evan Curtin is the May 2011 RSC ONS Challenge Winner

Posted on by

Evan Curtin, a chemistry freshman student working under the supervision of Jean-Claude Bradley at Drexel University, is the May 2011 Royal Society of Chemistry Open Notebook Science Challenge Award winner. He wins a cash prize from the RSC.

Evan's primary focus has centered on synthesizing aromatic imines and measuring their solubility in a number of organic solvents. This will allow us to generate Abraham descriptors for this class of compounds in order to predict their solubility in 70+ solvents. Coupled with our new model to include temperature dependent solubility, this should greatly facilitate optimal solvent prediction for this and related reactions.

Imine formation is of particular interest to the UsefulChem group because it is the first step of the Ugi reaction, which we have used to synthesize compounds with anti-malarial activity. But it is also a simple convenient reaction in itself to test our Solvent Selector's ability to predict optimal conditions (solvent and temperature) for isolation of products by precipitation.

Evan's synthesis experiments are available here:
http://usefulchem.wikispaces.com/Exp263
http://usefulchem.wikispaces.com/Exp262
http://usefulchem.wikispaces.com/Exp261


and his solubility experiments are listed here:
http://onschallenge.wikispaces.com/Exp207
http://onschallenge.wikispaces.com/Exp206
http://onschallenge.wikispaces.com/Exp205
http://onschallenge.wikispaces.com/Exp204
http://onschallenge.wikispaces.com/Exp201
http://onschallenge.wikispaces.com/Exp198
http://onschallenge.wikispaces.com/Exp197

Three more RSC ONS Awards will be made during 2011. Submissions from students in the US and the UK are still welcome.
For more information see:
http://onschallenge.wikispaces.com
http://onschallenge.wikispaces.com/RSCAwards2010

Anatomic Fashion Friday: Death Pumps

Posted on by

Taylor Reeves skull pumps

Kat von D in Taylor Reeves skull pumps

For 340 bones, 5.75 inches of bad ass could be yours!  These rhinestone pumps are made to order and each is custom painted by Taylor Reeves. I’m tempted to say that only Kat Von D can pull these off, but if you want to prove me wrong head to Reeves’ Etsy to order up a pair of your own.
There are also plenty of other (slightly) less flashy options, be sure to check them out!

 

 

The Gift of Life

Posted on by

Stephanie Kuga gift of life

Student Stephanie Kuga has created a series of package designs to promote organ donation. An entire series of organs, complete with facts and colored plush anatomy was created; you can see more work on her site, stephaniekuga.com.

Less than 30% of Americans are registered organ donors. These boxes would be given to potential donors to encourage them to give “the gift of life.” Current organ donation statistics, messages from patients on the waiting list, and a symbolic donor sticker behind the stuffed organs inform the new donor of the impact their decision will have on the lives of others.

Every organ donation marketing pitch I’ve seen has always been wildly creative. I wish more of them could be put into production!

 

Lecture: Mark Dion, "My Taxidermy Taxonomy," Museum of Natural History, London, Darwin Center, Thursday May 12

Posted on by


My good friend Petra Lange-Berndt at University College London would like to invite all of you London-based folks out there to a free and fascinating sounding lecture--as part of an equally fascinating sounding series--by one of my favorite contemporary artists, Mark Dion.

Full details on both the lecture and the series follow; hope you can make it!

"My Taxidermy Taxonomy"
Mark Dion (Visual Artist, USA)
Venue: Museum of Natural History, London, Darwin Center, Attenborough Studio
Time: Thursday, 12 May 2011, 5pm
The lecture is free and open to all - but please phone to book tickets on
+44 (0)20 7942 5725

Mark Dion is one of the world's foremost ecological artists. He is best known for investigating and intervening into the cultures of natural history collections through site-sensitive installations. In this slide lecture Dion will examine the ways in which dominant ideologies and public institutions shape our understanding of history, knowledge, and the natural world. The artist will address more specifically the politics of taxidermy, the preservation of animal skins, and its many practices. What kind of stories, curiosities and oddities can be unearthed from the archives of the natural history museum? How is taxidermy linked to extinction and colonialism? And what is the role of the museum in contemporary society?

This lecture is part of the AHRC Research Network "The Culture of Preservation" series, at the UCL History of Art Department, run by Petra Lange-Berndt and Mechthild Fend in collaboration with the Natural History Museum London, The Hunterian Museum, and the Grant Museum of Zoology, London.

More about this series:
Prepared specimens appear in many guises: as monstrous or typical organs preserved in formaldehyde and kept in glass jars not unlike pickled food, as stained and fixed tissue slices, or as skilfully arranged stuffed animals. They may be found in cabinets of curiosities, in the laboratories of histologists, in anatomy theatres or in natural history collections, but nowadays equally in art galleries and the shop windows of fashionable boutiques. This project is concerned with such kinds of preserved natural objects, in particular with anatomical wet preparations and taxidermy. It explorses the hybrid status of these objects between nature and representation, art and science and studies their fabricaton, history and display.

Events

Workshop 1: Taxidermy: Animal Skin and Colonial Practice
12 May 2011, 5pm
Keynote Lecture – free and open to all but please telephone to book tickets on +44 (0)20 7942 5725 –

Mark Dion (Artist, New York and Pennsylvania),
My Taxidermy Taxonomy, Museum of Natural History, London, Attenborough Studio

13 May 2011 Workshop

Workshop 2: Wet Preparations: Anatomy, Pathology and the Body Contained

9 June 2011, 6 pm Keynote Lecture – free and open to all –

Nick Hopwood (Historian of Science, University of Cambridge), Human embryos: bottled, sliced and frozen, Hunterian Museum at the Royal College of Surgeons

10 June 2011 Workshop

For further information please contact Mechthild Fend m.fend(@)ucl.ac.uk or Petra Lange-Berndt p.lange-berndt(@)ucl.ac.uk

The network is a collaboration between the UCL History of Art department, UCL collections, in particular the Grant Museum of Zoology, the Hunterian Museum, London and the Natural History Museum London.

The lecture is free and open to the public, but you will need to make reservations; you can do so by calling +44 (0)20 7942 5725. You can find out more about the event and the series by clicking here.

Image: Mark Dion: An Account of Six Disastrous Years in the Library for Animals (detail), Installation at the Centrum Sztuki Wspólczesnej, Zamek Ujazdowski, Warsaw 1992

Isolation of xylose isomerases by sequence- and function-based screening from a soil metagenome library

Posted on by

Background:
Xylose isomerase (XI) catalyses the isomerization of xylose to xylulose in bacteria and some fungi. Currently, only a limited number of XI genes have been functionally expressed in Saccharomyces cerevisiae, the microorganism of choice for lignocellulosic ethanol production. The objective of the present study was to search for novel XI genes in the vastly diverse microbial habitat present in soil. As the exploitation of microbial diversity is impaired by the ability to cultivate soil microorganisms under standard laboratory conditions, a metagenomic approach, consisting of total DNA extraction from a given environment, followed by cloning of the DNA into suitable vectors, was undertaken.
Results:
A soil metagenomic library was constructed and two screening methods based on protein sequence similarity (1) and enzyme activity (2) were investigated to isolate novel XI encoding genes. These 2 screening approaches identified the xym1 and xym2 genes, respectively. Sequence and phylogenetic analyses revealed that the genes shared 67% similarity and belonged to different bacterial groups. When xym1 and xym2 were overexpressed in a xylA deficient Escherichia coli strain, similar growth rates were obtained as when Piromyces XI gene was expressed. However, expression in S. cerevisiae resulted in only one fourth the growth rate of that obtained for the strain expressing Piromyces XI gene.
Conclusions:
For the first time the screening of a soil metagenomic library in E. coli resulted in the successful isolation of two active XIs. However the discrepancy between XI enzyme performance in E. coli and S. cerevisiae suggests that future screening for XI activity from soil should be pursued directly using yeast as a host.

Women Taking Calcium Supplements May Risk Heart Health, Researchers Say

Posted on by

(HealthDay News) -- More evidence is emerging that women who take calcium supplements to prevent bone deterioration may, in fact, be risking their heart health.

But even when added to previous studies with similar findings, the new conclusions don't necessarily mark a death knell for calcium supplements, say the authors of a study released online April 19 in the BMJ.

"There is a lack of consensus at the present time as to what recommendations should be regarding the use of calcium supplements," said study senior author Dr. Ian Reid, who fully expected that the new results will have a "significant impact on recommendations."

"Our own recommendation is to critically review the use of calcium supplements, since the data in this paper suggests that they do more harm than good," added Reid, who is professor of medicine and endocrinology at the University of Auckland in New Zealand. Read more...

AyurGold for Healthy Blood

Dr. Beach Visits Charlotte County Florida Beaches

Posted on by

Dr. Stephen Leatherman, known to all as “Dr. Beach,” is currently visiting Charlotte County beaches, grading them as part of his yearly beach contest to determine the 10 best beaches in the U.S. He will be visiting beaches on Knight Island (Palm Island Resort), Don Pedro Island and Little Gasparilla Island. Dr. Beach’s visit turned [...]

Final prep!

Posted on by
Black-headed Gull (300+ pairs) now on eggs

Scarce Fiddleneck now flowering

Final strimming before Terns nest

Wednesday 4th May comments: The final preparation work is under way as we are less than one week away from Arctic Terns landing and nesting. The final grass cutting and strimming is been done and thereafter its all over to the Arctic Terns. I'm not sure why we encourage these birds, as all our hard work is rewarded with constant attacks and plenty of bird guano covered clothes!

It all go on the islands although following the rush of the Easter break, visitor numbers have reduced but that won't stay that way for long. On the birding front, it remains quiet although four summer plumage Black-tailed Godwits was a nice discovery and the Swallows are nest building on the Longstone lighthouse.