Regeneration of the Pancreas, Demonstrated in Mice

Amongst the fast track papers at Rejuvenation Research, there is one that describes a stem cell therapy for regenerating damage to the pancreas.

We demonstrate that intravenous delivery of human, or rat, pancreas-derived pathfinder (PDP) cells can totally regenerate critically damaged adult tissue and restore normal function across a species barrier.

One of the more interesting aspects of this demonstration is that rat or human pathfinder cells introduced into mice spur rapid regeneration that produces overwhelmingly mouse tissue rather than rat or human tissue - and all without causing immune issues. These "pathfinder cells" are a form of stem cell found in adult tissues; the name is a branding effort by the for-profit research group Pathfinder, LLC, and is aimed at distinguishing in the marketplace the exact form of stem cell they work with. This process of branding cell configurations or particular forms of cellular reprogramming is something we'll be seeing much more of in the future, no matter how irritating it may be to folk who are just trying to follow the science.

You might find the press release an easier read than the research paper:

the Company's unique cell-based therapy is able to completely reverse diabetes in a mouse model. ... With only two treatments with [pathfinder cells], just days after induction of diabetes, we were able to quickly regenerate critically damaged pancreatic tissue, restoring and maintaining normal glucose levels and healthy body weight. ... Immunohistochemical analyses of animal tissues confirmed [that] treatment lead to regeneration of pancreatic beta-cells and formation of functional islets, which displayed normal architecture. Further examination determined that the regenerated islets consisted overwhelmingly of mouse cells, and to a much lesser extent, donor [rat or human] PCs (0.05-0.18%).

Reading between the lines, I'm given to wonder whether these "pathfinder cells" are in fact much the same thing as the very small embryonic-like stem cells that another group claims to exist in most tissues in the body.

One group of researchers believe that every tissue in the body is supported by a left-over population of fully pluripotent stem cells [(PSCs)] that might be easily accessible for use in therapies. ... In this review we present an evidence that adult tissues contain remnants from development; a population of PSCs that is deposited in various organs as a backup for primitive stem cells, plays a role in rejuvenation of the pool of more differentiated tissue-committed stem cells (TCSCs), and is involved in organ regeneration. These cells share several markers with epiblast/germ line cells and have been named very small embryonic-like stem cells (VSELs).

If, as here, researchers are already demonstrating promising results with stem cell populations isolated from adult tissues, then it shouldn't be too many more years before these forms of stem cell are well classified (and given more sensible names).

Proactiveinvestors Completes First European Presentations with NeoStem and International Stem Cell Corp

Proactiveinvestors completed its first investor forums in mainland Europe, in partnership with Milestone Media, last week, hosting presentations in Zurich and Munich with US listed companies NeoStem (AMEX:NBS) and International Stem Cell Corporation (OTC:ISCO).

Both investor forums were a great success, with notable attendees including Infidar Investment Advisory, BB Bellevue Asset Management, Centrum Bank, Taylor Wessing, BVMW and UBS Global Asset Management.

NeoStem’s CEO and Chairman Robin Smith updated investors on the company’s adult stem cell operations in the U.S., network of adult stem cell therapeutic providers in China, and recent acquisition of a 51% interest in a profitable Chinese generic pharmaceutical manufacturing company.

The company is focused on accelerating the development of proprietary cellular therapies and becoming a single source for collection, storage, manufacturing, therapeutic development and transportation of cells for cell based medicine and regenerative science globally.

NeoStem was recently given an initial "outperform" rating from US equity research firm Cowen, based on recent acquisitions and tie ups strengthening the company's adult stem cell banking capabilities.

Ken Aldrich, Chairman and Co-Founder of International Stem Cell Corporation also had plenty to introduce to European audiences. The California-based biotechnology company is focused on the therapeutic applications of human stem cells and the development and commercialization of cell-based research and cosmetic products.

The company’s core technology, Parthenogenesis, results in creation of pluripotent human stem cells from unfertilized oocytes. This technique avoids ethical issues associated with the use or destruction of viable human embryos and can be a source of therapeutic cells that minimize or eliminate immune rejection after transplantation into the patient.

What to look for when buying sunglasses?

From the NYTimes:

Unprotected exposure to sunlight can cause significant damage to the eyes
Sunlight can burn the surface of the eye, causing a temporary and painful condition known as photokeratitis. Over time, unprotected exposure can contribute to cataracts, as well as cancer of the eyelids and the skin around the eyes.

UV exposure also may increase the risk of macular degeneration, the leading cause of blindness in people over age 65.

What to look for when buying sunglasses?
Look for labels indicating at least “98 percent UV protection” or that it “blocks 98 percent of UVA and UVB rays.” If there is no label, or it says something vague like “UV absorbing” or “blocks most UV light,” don’t buy them.

For the best defense, look for sunglasses that “block all UV radiation up to 400 nanometers,” which is equivalent to blocking 100 percent of UV rays

Sunglasses should cover the sides of your eyes to prevent stray light from entering. Wraparound lenses are best. Look for close-fitting glasses with wide lenses. Avoid models with small lenses, such as "John Lennon-style" sunglasses.

UV protection is not related to how dark the lens is. Sunglasses tinted green, amber, red and gray may offer the same protection as dark lenses.

Polarized lenses block the horizontal light waves that create glare. But remember, polarization in itself will not block UV light.

You should be able to find a pair of drugstore sunglasses for $10 to $20 that provide all the protection you need.

References:
Let the Sunshine in, but Not the Harmful Rays. NYTimes, 2011.

Image source: OpenClipArt.org, public domain.

Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook.


Average time patients spend waiting to see a health-care provider is 22 minutes

The average time patients spend waiting to see a health-care provider is 22 minutes. Orthopedists have the longest waits, at 29 minutes; dermatologists the shortest, at 20.

Patient satisfaction dropped significantly with each 5 minutes of waiting time. Even the term "waiting room" has a bad connotation. Many offices prefer "reception area" instead.

"I live my life in seven-minute intervals," says Laurie Green, a obstetrician-gynecologist in San Francisco who delivers 400 to 500 babies a year and says she needs to bring in $70 every 15 minutes just to meet her office overhead.

Measures the health-care industry is trying to minimize waiting time include:

- "Open-access" scheduling
- Minimize office visits
- Advance preparation
- Huddling up: "Mr. Jones is in a 15-minute slot, but we know he's a 45-minute guy"
- Teamwork
- Cutting "cycle time"
- Keep patients informed
- Survey patients

References:

Image source: OpenClipArt.org, public domain.

Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook.


Rachel Kilback’s Pain

Rachel Kilback guilt

Guilt

Rachel Kilback dried

Dried

 

Rachel Kilback bite

Bite

 

Struggling with chronic pain and illness for most of her life has educated and inspired Rachel Kilback to transfer that energy straight into her art.

Rachel says of her work,

I long for freedom. Because of this I create art that has been called “reckless” and “intense”. Look for pain and struggle in my work. Nature features prominently in what I do. Material found in nature becomes integral to explorations of relationships between humans and other animals, as well as the female body and culture.

The works featured above are incredibly detailed representations of vaginas. Notice the sharp “teeth” on the last one, titled “Bite.”

 

View more of Rachel’s work on her portfolio site, elleavuleloup.ca

Matryoshka Dolls

Kim Hu Matryoshka Dolls front

Kim Hu Matryoshka Dolls back

I thought it would be great to compare this version of an anatomical nesting doll, by Kim Hu, with the previous post of Jason Leveque’s nesting doll.

Kim designed this lovely little nesting doll for a graduation project last spring for her Illustration and Design major.  I love that she created more layers of anatomy, down to the tiny skeleton. It’s fantastic!

 

 

Five tips for taking better underwater photographs

You’re on a beach getaway and would love to come back with some killer photos from the day you spent snorkelling or scuba diving in turquoise blue waters. Here are five basic tips to help you get those shots.
  1. Make sure your camera is sealed in a watertight case.
  2. Use anti-fog droplets on the lens before putting the camera in the watertight case.
  3. Shoot parallel to the ground and lower. Don’t point your camera into the light! The light should always be to the side or behind you.
  4. Have some kind point of reference so that we can tell where we are. This could be showing a hint of the ocean floor, a reef, the surface of the water above you, etc. Unless your motivation is to make a picture that feels like oblivion.
  5. Adjust the white balance (if your camera model has this feature). Without it, the picture will come out very bluey-green. White balancing will tone that down to give you truer colors, which is great if you don’t have Photoshop or any other picture-editing software.
Reefscape by Nick Hobogood

Photo credit: Wiki user Nick Hobgood http://en.wikipedia.org/wiki/File:Reefscape.jpg

Check out National Geographic’s David Doubilet for some excellent underwater photography.

Japan Tsunami Debris to Reach West Coast of USA in 3 Years

If you’re a serious beachcomber you’re probably already making a note on your calendar to look for debris from the Japan tsunami washing up on beaches in California, Oregon, Washington and Hawaii in about 3 years. That’s about how long it takes for flotsam to make its way across the Pacific Ocean via the North [...]

Jellyfish reports from the Florida Panhandle Beaches

Oliver Rhudy sent me these photos back on March 10, 2011. He wrote: “I am currently stationed in Pensacola and on a recent trip to Pensacola Beach, there were hundreds of Man-of-War washed up on the beach. I did get stung by a couple on the ankle but did not get medical attention. It was [...]

The one that got away…

Friday 1st April comments: So it was no surprise that the Great Auk sighting was false, as April fools day opened with a laugh. Some clever work from resident warden Graeme produced the image and the warden team enjoyed their brief but imaginary 'visitor to the clifftops'. Although it was all a laugh, it really is sad we have lost this bird for ever, as what a sight it must have been - the Farnes did actually once boast this incredible Auk, but not anymore.

Auk’in Hell!! A potential historical moment!?

Shock on the cliff tops - a Great Auk amongst Guillemots (Graeme Duncan)

Friday 1st April comments: This morning resident warden Graeme Duncan snapped a shot of a bird on Lighthouse cliff on Inner Farne which has proved to be that of a Great Auk. The species, last seen in 1840 on the outer reaches of northern Scotland, was seen briefly, allowing Graeme to snap the above photograph.

The news will shock and rock the birding world, as many have considered the species to be long extinct. The sighting has raised hopes of an undiscovered relict population which will hopefully re-colonise the Farnes in the near future.

Following much jubilation amongst the warden team, the bird moved off towards the nearby West Wideopens but has not been seen since. The bird appeared in good health and associated with the nearby Guillemots and we’ll keep everyone informed of any future sightings. WHAT a morning.

Nearly there…

Gadwall - a rare bird on the Farnes (Graeme Duncan)

Wednesday 30th March comments: It’s the build up to the big day – where opening to the public on Friday and we’re ready. We’ve worked hard getting the new interpretation ready, the Chapel polished, the boardwalks up to scratch and the jetties scrubbed. Its time we saw some friendly faces from the mainland. However the wardens have read the script but the birds haven’t – predictably the Auks have disappeared for a few days whilst everything else appears to be scarce apart from the Shags – some are now on three eggs! On the migrant front, a first-summer Iceland Gull roosted on Knoxes Reef whilst three Gadwall lingered around the Kettle – an unusual sight for the Farnes. Sandwich Tern numbers have peaked at 13 in the roost whilst common migrants such as Wheatear and Goldcrest continue to move through.

Island Treetop Villas

mandarin-oriental-turks-and-caicosMany island owners are looking at ways to make their islands more sustainable and environmentally friendly. One way island owners achieve this is through the integration of their architecture into the natural landscape.

Mandarin Oriental has taken this approach to the next level on their new island resort in the Turks and Caicos. The 8 villas in the the on the island pay homage to the hyper sensitivity of the location’s unique natural setting. Situated on Dellis Cay, the villas are designed to integrate nature as a major component of their material palette. The architecture was kept as simple as possible, ensuring that residents are able to fully take in the changing sky and surrounding vegetation.

All villas are precisely oriented to make the most of their vaulted position above the treetops, and each individual project has been carefully planned to maximize performative and experiential qualities. Each villa channels prevailing winds to cool the interior spaces while framing sunrises, sunsets, and the path of the moon from one side of the structure to the other. Given the limited number of resources on the island, a mixture of passive and active green building strategies were implemented throughout the projects including large overhangs, cross-ventilation, the use of recycled materials, solar hot water heaters, insulating green roofs, and rooftop infinity pools that also serve as a rainwater collection tanks.

Source: Inhabitat

Hilton Opens Second Resort in Seychelles

hilton seychellesIt is no secret that the world`s big hotel chains are opening resorts in some of the smallest regions of the world. Historically the domain of  boutique island resorts, regions like the Maldives and Seychelles are seeing an influx new high end resorts operated by some of the worlds best hotel brands.

Recently it was announced that the 111 villa Hilton Seychelles Labriz Resort and Spa opened on Silhouette Island the largest private island and third largest island in the Seychelles.  Just a 40-minute ferry ride from the main island of Mahé, the resort becomes the second Hilton Resort in the Seychelles.

“We are delighted to add Hilton Labriz Resort & Spa in the Seychelles to our portfolio,” Dave Horton, global head, Hilton Hotels & Resorts, said. “Recognised as one of the world’s leading leisure destinations, the Seychelles offers a combination of unique wildlife, cultural heritage and beautiful surroundings for our guests to enjoy. Travellers now have two great Hilton Resorts offering premium experiences across these picturesque islands.”

The rooms comprise of 30 garden villas with private terraces, 63 beachfront villas, which open onto white sandy beaches, 17 deluxe villas with private pools and one presidential suite with a private lounge and swimming pool. With five restaurants, guests are able to choose from an array of dining options, from Italian cuisine under the stars to international wines and cocktails at the pool side.

The resort’s Aquum Spa allows guests to unwind in treatment rooms built on stilts, amidst the rocks which emerge from the island jungle. Resort facilities include a water sports centre featuring scuba diving, snorkeling and fishing, a swimming pool, tennis court, library lounge, island boutiques, a medical centre, Wi-Fi internet and a DVD library.

Source: 4 Hoteliers.

Rabbit Island: Irish Island Rental

rabbit-island-ireland-3Ireland`s impressive landscapes are only enahnced when you pair them with the stunning beauty of their private islands.  One of the best known island retreats in Ireland is set deep in the heart of Mayfly Country on the Renowned Lough Corrib.

 Rabbit Island, a delightful 26 acre Island with a most charming and luxurious Fishing Lodge, is available for exclusive, short term Holiday and Angling Rental: Private, Serene, Magical; Your Own Fishing Haven is now available for bookings:

The property is accessed from Kennys Bay, a ten minute drive from Headford town: Galway is a half hour drive; Knock Airport an hour: Shannon one and a half hours.

The Accomodation Comprises: Living Room with feature fire place, french windows leading directly to the Verandah overlooking the lakeshore: Master Bedroom with En Suite, french windows leading to Verandah overlooking the lakeshore: Two Further Bedrooms downstairs, and two Upstairs Bedrooms with Shower Room: Pannelled Hallway, Fully Fitted Kitchen:

The Fishing Lodge dates from 1904 and has recently been extensively renovated and remodelled with all modern conveniences. There is a fine stone harbour with gated entrance to the lawns:

The Property can accomodate five persons comfortably: For bookings please contact: Helen Cassidy:

http://www.premierpropertiesireland.com
0035387 246 3748:

for more information visit private islands online.

The Official Roni Weiss Blog

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With double Bachelor of Arts degrees and a TEFL certificate in hand, Roni Weiss has ventured far afield from his native state of Washington. Between teaching gigs, he makes a point to travel the surrounding regions, has visited 70 countries and is not even close to being finished. He’s also delivered pizzas – maybe he’s rung your doorbell…


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Amritsar city of Sikhs

Amritsar is dirty noisy and smelly. We liked it so much we decided to stay 5 days.Let me explain the key attraction is the golden temple the holiest place in India for Sikhs. We went on day 1 in the midday sun and in all honesty I was ever so slightly frazzled by heat and underwhelmed. It's a temple it's golden. Um. But we went twice more early morning and late at night and were entirely

Narbonne 03.04.2011

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