Diluting Felicia | Bad Astronomy

It’s not hard to describe just how silly homeopathy is — after all, diluting a substance in water until nothing is left is clearly not a great way to base a medicinal practice. Unless you’re trying to cure dehydration. But if describing homeopathy’s silliness is easy, doing it well is another matter; most people don’t have a very good sense of scale when it comes to very big and very small numbers (I guess numbers that dwarf even a trillion weren’t necessary for our ancestors on the plains of Africa, so we never evolved a way to grasp them).

However, Steve DeGroof at MadArtLab (the same guy who does the skeptic web comic Tree Lobsters) has found a way to put homeopathy into perspective: use Felicia Day!

[You really must click through to see the whole thing.]

Well, pictures of her, anyway, and the concept of Felicia’s uniqueness. This is actually a pretty good analogy: you can put Felicia into various categories (like women named Felicia, redheads, guest stars on "House"*, and so on) and compare that number to how much homeopathy dilutes various solutions.

I think this ...


Is the Planet Warming? New research suggests the answer could depend on wording | The Intersection

Taeggan Goddard over at Political Wire sent over this interesting piece on research out of The University of Michigan. A new study found that the language used to describe our warming planet may influence listeners’ reactions.

According to research by Schuldt, Konrath, and Schwarz, Republicans are less likely to say that global climate change is real when it’s referred to as “global warming” (44.0%) instead of “climate change” (60.2%). Meanwhile, word choice does not seem to matter for Democrats. The investigators observed the partisan divide dropped from 42.9 percentage points when they used “global warming” to 26.2 percentage points when they used “climate change.”

In other words, language matters tremendously and the outcome of polls can be highly dependent upon it.


On Not Persuading the Unpersuadable | The Intersection

James Hrynyshyn has a new post up entitled “Why it’s hard to change a climate denier’s mind.” He uses it to channel the insights of Simon Donner, who argues that throughout the history of, like, all of humanity, people have considered themselves powerless to influence the climate. So why would that suddenly change?

I don’t doubt that this is a factor. However, it isn’t a partisan one; it suggests incredulity about human-induced climate change should be equally distributed across the populace.

Yet we know this isn’t the case. We know Republicans are much less accepting of climate science, and the idea that global warming is a problem, than Democrats and Independents.

We also know that those with “egalitarian” and “communitarian” value dispositions are much more concerned (and accepting of the science) than those with “individualist” or “hierarchical” value systems. For more on this, listen to my podcast with Dan Kahan.

So: I’m afraid I’m sticking with the view that partisanship and values, rather than anything hardwired about how we understand climate and weather, is the driver here. (At least in the U.S. context. I would guess that if you had a populace that wasn’t politically polarized, the factor Donner is highlighting might then come to the fore.)

P.S.: If you want to see some unpersuadables, check out this thread.


The Genetic Gamesmanship of a Seven-Sexed Creature | Discoblog

What could be better than two types of sexes? For one organism, the answer isn’t three, but seven! And to top it off, these seven sexes aren’t evenly distributed in a population, although researchers have now developed a mathematical model that can accurately estimate the probabilities in this crap-shoot game of sexual determination.

Meet Tetrahymena thermophila, which in addition to its seven different sexes—conveniently named I, II, III, IV, V, VI, and VII—has such a complex sex life that it requires an extra nucleus. This fuzzy, single-celled critter has a larger macronucleus that takes care of most cellular functions and a smaller micronucleus dedicated to genetic conjugation.

The other odd thing about this one-celled wonder is that the population of the seven sexes are skewed, leading Unversity of Houston researcher Rebecca Zufall and her colleagues to ask: What gives?

To answer that question, they created mathematical models of T. thermophila populations, and discovered that different versions of the same gene, or alleles, gave advantages to different sexes. Unlike humans, in which an individual’s sex is fully determined by its genes, the genotypes of these creatures provide only probabilities of developing ...


Science writing I’d pay to read | Not Exactly Rocket Science

“That’s brilliant. I’d pay good money for that.”

I’ve been saying this a lot recently. My RSS reader, Twitter stream and other sources of incoming goodies have been chock-full of stand-out pieces – posts that are long, thorough, beautifully written, and most of all, unpaid. Have a look at Greg Downey’s opus on the biology of holding your breath, or Delene Beeland’s piece on Ethiopia’s church forests, or Brian Switek’s post on human origins, or Bora Zivkovic’s tour de force on clock genes, or Steve Silberman’s… well pretty much everything by Steve Silberman.

I read these pieces in amazement that their writers should stick them up for free, when so many others pen far lesser works for a salary. Clearly, the writers are happy to provide free content and they get various advantages out of it. But I absolutely believe that good writers should be paid for good work. I read these pieces and think, “That took a lot of effort. It’s a shame they didn’t get paid for that. I’d pay good money for that.”

And then, last week, I thought, “Hey, why don’t I pay good money for that?”

So I’m going to. As of this month, I am putting my money where my mouth is and trying to set an example. The basic idea: every month, I’m going to choose ten pieces that I really enjoyed and donate £3 to the author as a token of my appreciation.

To clarify the rules further:

  • This excludes pieces written for paying mainstream institutions. This is for rewarding people who give content freely. I include bloggers who belong to paying networks like Discover, Scienceblogs and Wired, on the grounds that their rewards are fairly small and are typically based on traffic not, say, word count. So a great, long post may get no views (and earn no money) because it doesn’t have Lady Gaga in the URL.
  • There are no formal criteria about things like topic, length, style and so on. I naturally gravitate towards long-form journalistic pieces aimed at general audiences, but posts can make the list for all sorts of reasons not limited to making an important point, making me laugh, or being beautiful. Basically, whatever I enjoy with all the subjectivity that involves.
  • The number of pieces and the donation per piece may change as we go along – maybe more pieces, and less money for each – but they seem like reasonable figures for now and not vastly different from what, say, the Times charges for its paywall.

Of course, at £3, the reward to the author is pretty trivial but this is more of an acknowledgement that I as a reader enjoyed the work and felt it was worth my money. People might not want it or feel weird about it. That’s fine and probably expected, (although I would hope that no one would actually take offence at the idea) and I’ll just redistribute among the other candidates. But I do feel that these personalised micropayments are a bit unexplored and I want to explore them.

Then, there are the not inconsiderable logistical problems. How do I actually get the money to people? For the moment, I’m going to do it primitively-as-you-like. I will contact people on the list myself about their Paypal accounts, if they have them. Londoners can claim a pint off me, if they prefer (yes, that’s what booze costs in London).

Ultimately, I’d love to have some way for readers to make similar donations if they so chose to – otherwise, this might just turn into a small group of people swapping money. Maybe a Paypal button on the side, where all the proceeds in a given month are split between the chosen writers for that month? Or a button for each writer? Or maybe one where donations are split between me and the others? I’m open to suggestions about how this could work and whether readers would be happy to contribute.

In an ideal world, every blogger would have a Paypal button or similar on their site that I could click on. Some people find that uncomfortable; some networked bloggers can’t actually install one (for technical or policy reasons). Alternatively, everyone could use something like Flattr – it’s a great model, but it runs into the same problems. There could be a third-party site where people could register their Paypal accounts? Again, I’m keen to hear any suggestions.

I know this might all sound a bit strange to a lot of people and I cannot stress enough that this is a giving initiative, not a collecting one. I’m not asking everyone to start demanding money for their work. I’m saying that good writers are finding it increasingly difficult to make a living because companies are increasingly unwilling to pay good money for good writing. And that would be to everyone’s detriment. To an extent, I think it falls to the consumer to support good writing financially and, as a consumer, I am willing to do my part.

And without further ado, my picks for February. I will be in touch with these fine people soon:

IR M63. What RU? | Bad Astronomy

Y’know, I’ve posted a lot of really pretty and cool pictures of spiral galaxies lately, and I’ve given descriptions of how they have black holes in their cores, and how the spiral arms form, and where stars are being born, and and and.

So you know what?

Boom! There you go. [Click to galactinate it.] No fancy explanations, no expounding on the ethereal beauty of dust lanes in an infrared picture from Spitzer, no lectures on anything. Just a really, really pretty picture.

I mean, I could mention how this galaxy, M63, is nearby at only 37 million light years, and how I’ve seen it myself through my telescope. But no, I won’t do that. Nothing about the prevalent short, stubby arms — called spurs — or ring of dust circling the core. And certainly nothing on how the starlight has been subtracted from the image so all you see is warm dust.

Nope. Just the picture.

Pretty, isn’t it?

Image credit: NASA/JPL-Caltech

Related posts:

- Gallery: Spitzer’s greatest hits
- The Milky Way’s (almost) identical twin
- A galaxy that’s all hat and no head


The Science of Mardi Gras | The Intersection

I’m in New Orleans this week, doing some writing and also attending…Mardi Gras. I just saw my first parade, Muses, last night.

Which inspired the joking title of this blog post. For fun, I Googled the phrase “the science of mardi gras” to see what turned up. All I got was a bizarre reference to a pretty unscientific comment by Anderson Cooper:

It’s a very public event, of course, but there’s something intensely personal about the throwing of the beads. You make eye contact with someone, toss them a necklace. They say thank you, and you roll on. The only beads people want are the ones they catch themselves. I find that very telling. The beads that fall on the ground are rarely picked up. They lack the personal connection, the bond has been broken.

That’s not my experience of Mardi Gras. My experience is that the good beads are fought for, and kids scavenge on the ground for whatever isn’t caught. If a bead is still lying on the ground it’s because it’s broken.

What’s more, as a look at the “science of mardi gras” this is pretty lame. A real science of Mardi Gras might examine, say, the strange and artificial economy that gets created for a short span of time. In this economy, completely worthless beads suddenly come to have a temporary but real value–especially if they’re plastic pearls–even as more “scarce” throws, like coconuts, spears, etc, are valued still higher. (Of course, the ones really making money are the people selling beads by the “gross”–a bag of 144 individual ones–for more than $ 20, just so they can be thrown off of floats.)

There would also be a lot of studies of alcohol’s effects on group behavior. So–Mardi Gras’s “science” very much awaits.


How technology makes ideology irrelevant | Gene Expression

Dienekes points to two interesting phenomena which when juxtaposed together show how the pace of technological change can outrun ideological arguments and hand wringing. Those of you who have been reading me since the early 2000s know where I stand on issues such as the “Kennewick Man” controversy. I think there’s an objective reality which should be studied. The latter is a normative judgement. There’s no rule embedded in the universe that truth needs to be set free, it’s a preference. So when it comes to Creationism of organized institutional religions, or shamanic ethnic Creationism, I don’t put much weight in its value or importance. But the shadow of Kennewick Man still looms over contemporary controversies as we crest the peak swell of human genomics in terms of the rate of increase of insight. Apparently members of the America Indian Program at Cornell are objecting to The Genographic Project. The project is headed by Spencer Wells, who has an appointment at Cornell now. An English professor associated with the American Indian Program apparently sent the student newspaper an almost parody-like email of impenetrable obfuscating academic-speak:

In a statement issued by AIP, the program’s director, Prof. Eric Cheyfitz, ...

Friday Fluff – March 4th, 2011 | Gene Expression

FF3

1) First, a post from the past: Evolution: What the Fossils Say and Why It Matters.

2) Weird search query of the week: “are you allowed to drink alcohol in class.”

3) Comment of the week, in response to “Are we still evolving”:

You know what would actually be a hoot for a documentary?

What if we ran SNP chips on several people who study Neandertals, and I tell them which Neandertal parts they have, all in front of the cameras.

That would be so much fun!

4) 4) And finally, your weekly fluff fix:

NCBI ROFL: Smelly Week: The science of “the stinkface”. | Discoblog

It’s smelly week on NCBI ROFL! All week long we’ll feature the funniest papers about the science of stink. Enjoy!

Gustofacial and olfactofacial responses in human adults.

“Adults’ facial reactions in response to tastes and odors were investigated in order to determine whether differential facial displays observed in newborns remain stable in adults who exhibit a greater voluntary facial control. Twenty-eight healthy nonsmokers (14 females) tasted solutions of PROP (bitter), NaCl (salty), citric acid (sour), sucrose (sweet), and glutamate (umami) differing in concentration (low, medium, and high) and smelled different odors (banana, cinnamon, clove, coffee, fish, and garlic). Their facial reactions were video recorded and analyzed using the Facial Action Coding System. Adults’ facial reactions discriminated between stimuli with opponent valences. Unpleasant tastes and odors elicited negative displays (brow lower, upper lip raise, and lip corner depress). The pleasant sweet taste elicited positive displays (lip suck), whereas the pleasant odors did not. Unlike newborns, adults smiled with higher concentrations of some unpleasant tastes that can be regarded as serving communicative functions. Moreover, adults expressed negative displays with higher sweetness. Except for the “social” smile in response to unpleasant tastes, adults’ facial ...


Next Jobs Outsourced to Robots: Killing Snakes, Playing Basketball, Self-Replicating | Discoblog

To make a dent in brown snake populations, feed them poison-stuffed mice; to devastate brown snake populations, create robots to do the job for you. That’s what conservationists want to do in Guam to stop these pesky reptiles from further destroying the native bird population. The robots would have to stuff mice with 80 milligrams of acetaminophen (poisonous to snakes), glue the mice to cardboard strips, and then attach paper streamers to these monstrosities—all so that these modern day Trojan horses get lodged in the snake’s forest canopy when they’re lobbed out of airplanes (and hopefully wind up in a snake’s tummy).

But that’s not all the the mischief that robots have been up to recently:

The U.S. Navy wants to start dabbling in robots too: Semi-autonomous micro-robot swarms that could themselves manufacture their own robots. Cute, huh? In a project proposal for scientists, the Navy says it’s looking for a few good robots that can “pick and place, dispense liquids, print inks, remove material, join components” and “move cooperatively” to manufacture “novel materials and structures.” Prepare now for the robot apocalypse! (No, ...


Nerd alert! | Gene Expression

Apparently July 12th, 2011, is now a hard date for the publication of George R. R. Martin’s A Dance with Dragons, the 5th book in his A Song of Ice and Fire series. Martin has confirmed the date on his website: “Barring tsunamis, general strikes, world wars, or asteroid strikes, you will have the novel in your hands on July 12. I hope you like it.” He even has a late-1990s style countdown going. For what it’s worth, the first book, A Game of Thrones, came out in the summer of 1996. That means that a 10 year old starting the series in 1996 would be 25 now. In all probability this is going to be ~10 books, so who knows how old that 10 year will be when it’s all done.

Personally, I found that the last book was kind of a let down. Amazon reviewers seem to agree, as books 1-3 got 4.5 stars, but book 4 only 3. If Martin can’t bounce back, I assume that this series going to go the way of The Wheel of Time (before it was resurrected ...

Gene Therapy for HIV Resistance Succeeds in Trials—But Hold the “Cure” Talk | 80beats

Earlier this week at a scientific conference in Boston, HIV researchers announced a remarkable success in countering the virus’ drain on the immune system. But this early step is far from a cure.

Why it’s exciting:

Carl June and colleagues tested six male patients who already had HIV and were taking a standard antiviral regimen. Like many HIV patients, the drugs helped them, but their counts of immune cells stayed low. June’s team tested a therapy created by Sangamo BioSciences in Richmond, California, that alters a patient’s actual white blood cells to make them more HIV-resistant.

Researchers removed a sample of CD4+ T cells, the type of immune cells affected by HIV, from each man and used Sangamo’s enzyme to disrupt the CCR5 gene, which encodes a protein that HIV uses to enter CD4+ cells. The engineered cells were then infused back into the patients. Immune-cell counts subsequently rose for five of the six patients who received the therapy. “It’s very exciting,” says John Rossi, a molecular biologist at the City of Hope’s Beckman Research Institute in Duarte, California. “If they did ...


More images of exoplanet show it orbiting its star | Bad Astronomy

Although well over 500 planets orbiting other stars are known to exist — and we know of many, many more awaiting confirmation — direct images of the planets are very rare. That’s because stars are billions of times brighter than planets, and the planets tend to huddle so closely to their star that their feeble light gets overwhelmed.

But it’s possible, and we have several images of such exoplanets. One of them is Beta Pictoris b, a super-Jupiter orbiting the star Beta Pic (as we in the know call it) about as far out as Saturn orbits the Sun. Its existence was confirmed in 2009, but it was also seen in earlier images in 2003 and 2008. The motion of the planet from one side of the star was obvious, and now observations from March 2010 again show it has moved as it orbits the star:

Pretty cool! These infrared images from the Very Large Telescope all have the starlight removed to show the faint planet (the faint rings and other blobs are optical effects and can be ignored). The upper left picture is from 2003; the upper ...


Cognitive Enhancers are Not “Cheating” | Science Not Fiction

Matt Lamkin argues that universities shouldn’t ban cognitive-enhancing drugs like Ritalin and Adderall. Lamkin is a lawyer and, like myself, a master’s candidate in bioethics. He rightly believes that a ban would do little to promote fairness or safety among students. The rule followers would be at a disadvantage while the rule-breakers would be at a greater safety risk. But Lamkin doesn’t believe we, as a society, should be ok with cognitive enhancement usage. Instead, he argues:

The word “cheating” has another meaning, one that has nothing to do with competition. When someone has achieved an end through improper means, we might say that person has “cheated herself” out of whatever rewards are inherent in the proper means. The use of study drugs by healthy students could corrode valuable practices that education has traditionally fostered. If, for example, students use such drugs to mitigate the consequences of procrastination, they may fail to develop mental discipline and time-management skills.

On the other hand, Ritalin might enable a student to engage more deeply in college and to more fully experience its internal goods—goods she might be denied without that assistance. The distinction suggests that a ...


Single protein can strengthen old faded memories | Not Exactly Rocket Science

[This is the first of three intertwined posts on PKMzeta - the molecule that keeps our memories intact]

We’re used to the idea that we become more forgetful with age. As time passes, our memories naturally fade and weaken, and that’s if we’re lucky enough to avoid traumatic accidents or diseases like Alzheimer’s. But Reut Shema, from the Weizmann Institute of Science in Israel, has found a possible way of preventing this decline, and even reversing it.

By loading the brains of rats with a protein called PKMzeta, she managed to strengthen their memories, even old and faded ones. “Multiple old memories were robustly enhanced. These results have no precedent,” says Todd Sacktor, who led the study together with Yadin Dudai.

PKMzeta is the engine of memory. This single protein behaves like a machine that constantly works to keep our memories intact. Switch it off, and we forget things permanently. It’s our lone defence against a constant tide of forgetfulness that threatens to revert our brains back to a blank slate (see “Exposing the memory engine”).

In 2007, Shema, Dudai, and Sacktor showed how important PKMzeta is by inactivating it in the brains of rats using a chemical called ZIP. They trained the rodents to avoid an artificial sweetener before injecting ZIP into the part of their brain involved in taste. The chemical irreversibly erased their distaste for sweetener. Even if they’d learned to avoid it a month earlier (several years in human terms), they forgot all about it once ZIP had blocked their PKMzeta. The protein’s powers aren’t limited to taste. Shema, Sacktor and others have since disrupted all sorts of memories by blocking PKMzeta, from old fears to motor skills to the location of objects.

These were a compelling result but the team hadn’t entirely sealed their case. “People have done science where you block things to see what happens, but you don’t really know what’s going on,” explains Karim Nader, a memory researcher at McGill University, who has worked with Sacktor before. ”You think it’s the equivalent of a smart bomb, but maybe it’s a dirty bomb. You block something in the brain and there are eight million things that could happen. So you have to enhance it and see if you have the opposite effect.”

And that’s exactly what Shema has now done. Once again, she taught rats to avoid the taste of sweetener. This time, a few days before their training, she infected the rats’ brains with viruses carrying PKMzeta. With extra copies of the protein at hand, the rats were more likely to remember their distaste for sweetener. Even if Shema injected the viruses a week after the rats’ training, when their aversion to the sweetener had started to fade, the extra PKMzeta enhanced their dulled memories.

“That’s the grand slam,” says Nader. “It’s got to be that molecule.”

Sacktor thinks that PKMzeta is unique in being able to boost old memories in healthy animals. In 2007, Li-Huei Tsai managed to reinstate lost memories in rats by chemically blocking a group of proteins called histone deacetylases. These chemicals stop DNA from scrunching up, which makes the genes within it easier to reach. But Tsai only did this in rats that suffered from a type of dementia. “That’s not the same thing as enhancing a normal animal’s old memories and making them stronger,” says Sacktor.

There are also many ways of strengthening memories in their earliest stages, when they first form and when they move from short-term to long-term storage. Rehearing the same information can help, as can a good nap. Just last month, I reported on a protein called IGF-II that can do the same. “But what we have with PKMzeta is unprecedented, in that you can take old memories that have already been around for a week and make them stronger,” says Sacktor. “That’s what’s really different about this.”

The viruses apparently weren’t just flooding the brain with PKMzeta, indiscriminately strengthening all the nearby synapses. Instead, the extra protein appears to have ended up in some synapses but not others. “This in a sense is just as remarkable,” says Sacktor. “You put in more of it and you don’t screw up the whole system. PKMzeta somehow knows how to fit into the memories that are already there.” Sacktor thinks that PKMzeta is drawn to itself. It somehow ends up in the right places and strengthens connections that have already been tagged by existing PKMzeta.

“Think about zeroes and ones on a hard disk,” he says. Removing PKMzeta with ZIP is like erasing information by flipping all the ones to zeroes. “Now we’re saying we’re putting in more ones, but it’s like they’re going where the other ones are, rather than randomly going to ones or zeroes.” This strange homing ability could help us integrate new information to existing memories, or to make sense of our memories over long periods of time. It’s the strangest aspect of PKMzeta and the one that Sacktor is most eager to crack. (See “Todd Sacktor talks about the memory engine”)

For now, David Sweatt, who studies memory at the University of Alabama, says that the new study is a “significant step forward” that greatly strengthens the role for PKMzeta in memory. “The identification of PKMzeta activators as potential cognition-enhancing agents is particularly exciting.”

But Sacktor is rightly cautious about any applications. “First of all, I don’t think we’re going to be using viruses!” he says. Rather than introducing extra copies of the PKMzeta gene, the ultimate goal is to work out how the brain makes the protein itself and give that process a boost. Even then, it’s difficult to say anything about benefits or risks, when people have only done studies in rats.

“One really doesn’t know how this would work out in people,” says Sacktor. Remembering every experience in painful detail might not be a pleasant or useful experience. “I think the point is more for people whose memories are falling apart because of neurodegeneration. There could be good and bad things about enhancing memory, but in people who are losing their memory, I think it makes sense. If people can’t remember whether they left their stove on or they can’t remember their children…”

Reference: Shema, R. (2011). Enhancement of Consolidated Long-Term Memory by Overexpression of Protein Kinase Mz in the Neocortex Science DOI: 10.1126/science.1200215

Image by KayVee

More on PKMzeta

More on memory:

Space leaders to Congress: Light this commercial candle! | Bad Astronomy

I received a very interesting email from Alan Stern — head of the New Horizons Pluto flyby mission, and who, for a year, was NASA’s Associate Administrator for the Science Mission Directorate.

Here’s what it said:

The attached open letter was sent to Congress today after being signed by over 55 space leaders.

The letter urges Congress to fully fund NASA’s plan to use commercial companies to carry crew to the Space Station.

Among the letter’s signatories are an unusually broad group of former NASA executives and advisors, former astronauts, CEOs and directors of firms large and small, space scientists, space journalists, and others. We include 14 former NASA astronauts, 5 former NASA senior executives, 13 educators and nonprofit leaders, and 24 space industry leaders from a wide variety of firms and institutions, both large and small.

I am a big advocate of this, having written many times that NASA should be exploring and creating new technologies, but should not be in the business of hauling stuff to space. That is better — and more cheaply — done by commercial contractors.

I’ve put the entire letter online here for you to read.

Here’s one ...


News Roundup: Why the Sun Lost Its Spots | 80beats

While modeling plasma flows deep inside the sun, scientists may have found an explanation for why some sunspots cycles (like the most recent one) are weaker than others. “It’s the flow speed during the cycle before that seems to dictate the number of sunspots. Having a fast flow from the poles while a cycle is ramping up, followed by a slow flow during its decline, results in a very deep minimum.”
Risky business: In defending President Obama’s vision for space exploration that relies upon commercial space companies, NASA administrator Charles Bolden says the country must “become unafraid of exploration. We need to become unafraid of risks.”
Bad timing: Just as Apple unveils its new iPad—and Steve Jobs uses the opportunity to gloat about his company’s superiority in apps compared to Google’s Android system—Google had to take 21 apps off the Android Market because they were infected with malware.
The journals of Harvey Cushing, the father of neurosurgery, include admirable documentation of his own mistakes—giving medical historians a window into the birth of modern surgery around the turn of the 20th ...