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Pineville's Louisiana College hedges on law school site, but is 'excited to ...
Alexandria Town Talk
Lawson did say that he hoped Alexandria could remain in consideration for a medical school LC has on the drawing board. Speaking on KSYL radio Thursday ...
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Private Island Fights Public Access to Bridge in Newport Beach

Private island fightThe great thing about Private Islands is that you don’t have to worry about neighbours. Well not always. Residents on a Private Island in Newport Bay are suing the California Coastal Commission to keep their pedestrian bridge from opening to the general public.

The Los Angeles Times recently explained the dispute noting that the Coastal Commission contends that the Bay Island Club, an association of 24 homeowners on the tiny island by that name, must allow public access to the bridge if the club wants to replace the aging 130-foot span. It’s a classic example of the struggle between private landowners and state government, which since the 1976 passage of the California Coastal Act, has aggressively protected the public’s access to shorelines and waterways.

The city owns the  canal under the bridge and the Newport Beach City Council voted unanimously July 27   to support the islanders in court. The island is about halfway down the Balboa Peninsula.

Defendants of the island state: “Yes, it’s across public property,” said Councilman Don Webb. “But it really has no use other than coming on and off the island.”

 

Coastal commissioners can picture people fishing, strolling and exploring the views from the footbridge. The commissioners say that the city is required to keep it public.

“We felt that we needed to protect the public’s interest in access to public waters,” said Christopher Pederson, deputy chief counsel for the commission.

Hopefully a fair and equitable compromise can be reached in this case. However it seems unfair that the islands residents are being asked to foot the bill for the new bridge but the coastal commission expects free public access.  In addition since the island is private property it seems there would be no need for the general public to be on the bridge in the first place.

To read more about this issue visit the Los Angeles Times

Fermi Detects ‘Shocking’ Surprise from Supernova’s Little Cousin

Astronomers using NASA's Fermi Gamma-ray Space Telescope have detected gamma-rays from a nova for the first time, a finding that stunned observers and theorists alike. The discovery overturns the notion that novae explosions lack the power to emit such high-energy radiation.

A nova is a sudden, short-lived brightening of an otherwise inconspicuous star. The outburst occurs when a white dwarf in a binary system erupts in an enormous thermonuclear explosion.

"In human terms, this was an immensely powerful eruption, equivalent to about 1,000 times the energy emitted by the sun every year," said Elizabeth Hays, a Fermi deputy project scientist at NASA's Goddard Space Flight Center in Greenbelt, Md. "But compared to other cosmic events Fermi sees, it was quite modest. We're amazed that Fermi detected it so strongly."

Gamma rays are the most energetic form of light, and Fermi's Large Area Telescope (LAT) detected the nova for 15 days. Scientists believe the emission arose as a million-mile-per-hour shock wave raced from the site of the explosion.

A paper detailing the discovery will appear in the Aug. 13 edition of the journal Science.

The story opened in Japan during the predawn hours of March 11, when amateur astronomers Koichi Nishiyama and Fujio Kabashima in Miyaki-cho, Saga Prefecture, imaged a dramatic change in the brightness of a star in the constellation Cygnus. They realized that the star, known as V407 Cyg, was 10 times brighter than in an image they had taken three days earlier.

The team relayed the nova discovery to Hiroyuki Maehara at Kyoto University, who notified astronomers around the world for follow-up observations. Before this notice became widely available, the outburst was independently reported by three other Japanese amateurs: Tadashi Kojima, Tsumagoi-mura Agatsuma-gun, Gunma prefecture; Kazuo Sakaniwa, Higashichikuma-gun, Nagano prefecture; and Akihiko Tago, Tsuyama-shi, Okayama prefecture.

On March 13, Goddard's Davide Donato was on-duty as the LAT "flare advocate," a scientist who monitors the daily data downloads for sources of potential interest, when he noticed a significant detection in Cygnus. But linking this source to the nova would take several days, in part because key members of the Fermi team were in Paris for a meeting of the LAT scientific collaboration.

"This region is close to the galactic plane, which packs together many types of gamma-ray sources -- pulsars, supernova remnants, and others in our own galaxy, plus active galaxies beyond them," Donato said. "If the nova had occurred elsewhere in the sky, figuring out the connection would have been easier."

The LAT team began a concerted effort to identify the mystery source over the following days. On March 17, the researchers decided to obtain a "target-of-opportunity" observation using NASA's Swift satellite -- only to find that Swift was already observing the same spot.

"At that point, I knew Swift was targeting V407 Cyg, but I didn't know why," said Teddy Cheung, an astrophysicist at the Naval Research Laboratory (NRL) in Washington, D.C., and the lead author of the study. Examining the Swift data, Cheung saw no additional X-ray sources that could account for what Fermi's LAT was seeing.

V407 Cyg had to be it.

Half an hour later, Cheung learned from other members of the LAT team that the system had undergone a nova outburst, which was the reason the Swift observations had been triggered. "When we looked closer, we found that the LAT had detected the first gamma rays at about the same time as the nova's discovery," he said.

V407 Cyg lies 9,000 light-years away. The system is a so-called symbiotic binary containing a compact white dwarf and a red giant star about 500 times the size of the sun.

"The red giant is so swollen that its outermost atmosphere is just leaking away into space," said Adam Hill at Joseph Fourier University in Grenoble, France. The phenomenon is similar to the solar wind produced by the sun, but the flow is much stronger. "Each decade, the red giant sheds enough hydrogen gas to equal the mass of Earth," he added.

The white dwarf intercepts and captures some of this gas, which accumulates on its surface. As the gas piles on for decades to centuries, it eventually becomes hot and dense enough to fuse into helium. This energy-producing process triggers a runaway reaction that explodes the accumulated gas.

The white dwarf itself, however, remains intact.


The blast created a hot, dense expanding shell called a shock front, composed of high-speed particles, ionized gas and magnetic fields. According to an early spectrum obtained by Christian Buil at Castanet Tolosan Observatory, France, the nova's shock wave expanded at 7 million miles per hour -- or nearly 1 percent the speed of light.

The magnetic fields trapped particles within the shell and whipped them up to tremendous energies. Before they could escape, the particles had reached velocities near the speed of light. Scientists say that the gamma rays likely resulted when these accelerated particles smashed into the red giant's wind.

"We know that the remnants of much more powerful supernova explosions can trap and accelerate particles like this, but no one suspected that the magnetic fields in novae were strong enough to do it as well," said NRL's Soebur Razzaque.

Supernovae remnants endure for 100,000 years and affect regions of space thousands of light-years across.

Kent Wood at NRL compares astronomical studies of supernova remnants to looking at static images in a photo album. "It takes thousands of years for supernova remnants to evolve, but with this nova we've watched the same kinds of changes over just a few days," he said. "We've gone from a photo album to a time-lapse movie."

For more information visit http://www.nasa.gov/mission_pages/GLAST/news/shocking-nova.html

Citizen Science: Will NASA Lead or Fall Behind?

Citizen Scientists Discover Rotating Pulsar, NSF

"Idle computers are the astronomers' playground: Three citizen scientists--an American couple and a German--have discovered a new radio pulsar hidden in data gathered by the Arecibo Observatory. This is the first deep-space discovery by Einstein@Home, which uses donated time from the home and office computers of 250,000 volunteers from 192 different countries. This is the first genuine astronomical discovery by a public volunteer distributed computing project"

Using Simple Tools To Reach Millions

NASA Scientists to Share Ideas at SETIcon Gathering

"NASA scientists will join space experts, celebrities and science fiction writers to discuss science, entertainment and celebrate the 25th anniversary of the SETI Institute, Mountain View, Calif., at the SETIcon, Aug. 13-15, 2010 at The Hyatt Regency Santa Clara House, 5101 Great America Parkway, Santa Clara, Calif."

Keith's note: Alas, even though scientists engaged in SETI can scour the heavens, across many light years using exquisite, cutting-edge radio astronomy equipment, yet as far as I can tell, neither they (or ARC PAO) know how to webcast a conference to humans on Earth using a laptop and commonly available software. I did this from Everest Base Camp for crying out loud.

NASA Exploration Systems Directorate Commercial Crew Planning Status Forum

"NASA will present an overview of common themes captured from industry responses provided to NASA's Commercial Crew Initiative Request for Information (RFI) published on May 21, 2010. The forum will include a general discussion of how these common themes are being addressed by NASA; presentation of the insight/oversight philosophy; and a question and answer session. The event will be conducted on August 19, 2010, at NASA Headquarters, James E. Webb Auditorium, 300 E Street SW, Washington DC from 9:00 a.m. to 11:30 a.m. NASA will broadcast the forum live on NASA TV and online via webcast. TV and Web viewers will have the opportunity to submit online questions and comments during the forum."

Keith's note: Ah great, one week advanced notice. But at least they will be webcasting and broadcasting the event - with online interaction as well.

Was Thinking Tonight About the Greatness of Carl Sagan | The Intersection

The opening lines of Cosmos:

The Cosmos is all that is, or ever was, or ever will be.

Our contemplations of the Cosmos stir us.

There’s a tingling in the spine, a catch in the voice…

A faint sensation, as if a distant memory of falling from a great height.

We know we are approaching the grandest of mysteries.

(Fully 30 years ago. And yes, I know that with our modern sensibilities, it feels a little bit cheesy…but still. You know you love it.)


Cascio quote on geoengineering

"But here's the ugly truth: nature doesn't care about democracy, or who's right, or what's fair. And because of the slow-change aspect of climate, we can't wait until the worst effects are upon us to make a decision -- by then, it would be far, far too late. The scenario we may be faced with is one where doing something for the wrong reasons, run by the wrong people, may still save more lives than holding out for a more appealing option." - Jamais Cascio

Link.

Guide to Travel Writing

Travel Writing 2.0, available now from veteran travel writer and editor Tim Leffel, guides aspiring writers through the current transition period from print media to the digital era.

Making ‘Social Media’ Social

At HostingCon 2010, I joined (Curtis) R. Curtis, Nick Longo and Matt Balleck on a panel to discuss how hosters and entrepreneurs can optimize social media for branding, traffic and sales. When you start talking “social media,” you’re almost guaranteed a great turnout, and this session was no exception. The standing room-only crowd asked some great questions of the panel, and despite my blog audience-selected attire, many flagged me down to keep the conversation going.

The session allotted each presenter a few minutes to share some best practices from their experience with Twitter, Facebook and YouTube before the floor was opened to questions. Nick Longo led off with an excellent rundown of Rackspace’s high-level Twitter strategy. He discussed how the company approaches social media and the paramount importance of engaging employees and personal networks to connect with people to share a value-rich message. His personal strategy when it comes to posting on Twitter is to load the channel with value for his audience … even when that value isn’t directly related to his company. By focusing on his audience’s interests and injecting business content only where relevant, he’s built a fantastic following.

vidiSEO‘s Matt Ballek, stepped up to the microphone next and brought the thunder by sharing some much-appreciated tips about how businesses can optimize their YouTube videos. If pictures are worth a thousand words, his “YouTube Video SEO – How to Optimize Your YouTube Video” interactive presentation is probably worth a few million, so I’d highly recommend you check it out to learn about the four pillars of optimizing your videos.

Following those future Hall of Famers, the pressure was on when I stepped up to the podium. Luckily, my presentation didn’t turn out to be a “Casey at the Bat” situation. I shared some of our social media successes with the crowd by explaining how and why #showmemyserver, the #500Club and The Planet Server Challenge worked as well as they did. If you’ve been around the neighborhood here for a while, you’re well versed with those campaigns, and if you’re unfamiliar, scroll down to the last paragraph to learn how you can earn the chance watch a video of my presentation. In the meantime, take a look at the slides we covered:

(Curtis) R. Curtis batted cleanup on the panel by sharing a few tips and tricks for businesses on Facebook. He touched on the fact that “personal” nature of the medium makes it tough to sell to users, but that shouldn’t dissuade businesses and entrepreneurs from building qualitative connections with customers by allowing them to connect and interact with the company and each other.

Given my presentation’s focus on user engagement, it seems only fitting that this blog have an opportunity for you to earn a bonus by becoming a part of the conversation. Leave a comment below with a few “words of wisdom” you’ve gleaned from your experience with social media, and I’ll email you a link to a video of my presentation. Along with my brilliant speech delivery, you’ll get a peek at “the hipster look.”

What else could you want?

-Kevin

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FDA files injunction again Regenerative Sciences citing Regenexx violates regulations

For those of you who follow this blog, you'll imagine my surprise to wake up the morning to the following announcement from the FDA:
_____________________________________________________________
FDA NEWS RELEASE
For Immediate Release: August 6, 2010
Media Inquiries: Shelly Burgess, 301-796-4651, shelly.burgess@fda.hhs.gov
Consumer Inquiries: 888-INFO-FDA
FDA Seeks Injunction Against Colorado Manufacturer of Cultured Cell Product
Violations of current good manufacturing practice and labeling requirements cited
The U.S. Food and Drug Administration is seeking an injunction in federal court against Regenerative Sciences LLC, of Broomfield, Colo., citing violations of current good manufacturing practice (cGMP) that cause its cultured cell product to be adulterated. The product is also misbranded due to the lack of adequate directions for use and the failure to bear the “Rx only” symbol.
The company’s cultured cell product is derived from a patient’s bone marrow or fluid surrounding the patient’s joints (synovial fluid). The cells are grown, processed, and mixed with drug products outside the body before being injected back into the patient.
Regenerative Sciences’ cultured cell product is not approved by the FDA, and no adequate and well-controlled studies have been done to demonstrate its safety or effectiveness for any indication.
“FDA recognizes the importance of the development of novel and promising new therapies,” said Karen Midthun, M.D., acting director of FDA’s Center for Biologics Evaluation and Research. “However, when companies like Regenerative Sciences fail to comply with FDA laws and regulations, they put the public’s health at risk.”
The complaint for the injunction was filed Aug. 6, 2010, by the Justice Department on behalf of the FDA in the U.S. District Court for the District of Columbia, against Regenerative Sciences and three of its employees, Christopher J. Centeno, M.D., John R. Schultz, M.D., and Michelle R. Cheever. The injunction would permanently prevent the company and cited individuals from adulterating and misbranding the cultured cell product while the product, or one or more of its components, is held for sale after shipment in interstate commerce.
Regenerative Sciences has agreed to cease production of the cultured cell product while the case is pending.
The FDA warned Regenerative Sciences about its cGMP violations as recently as June 2010. The company failed to make sufficient corrections, and the conduct of the individuals cited in the complaint demonstrates refusal to comply with the law.

Updates in Pediatrics

You can find this information on PubMed but this is a nice summary from UpToDate (only brief highlights are posted below, check the source link for full text):

Sexually transmitted infections

25% of urban adolescent females (14-17 years of age) were diagnosed with a sexually transmitted infection (STI) within one year of first intercourse.

Attention deficit hyperactivity disorder (ADHD)

ECG screening should not be required before initiating stimulant therapy for patients with ADHD.

Autism prevalence

The prevalence of autism spectrum disorders (ASD) among eight-year-old children in the United States increased from 1 in 150 children in 2000 to 2002 to approximately 1 in 111 in 2006. No clear reason for increase has been found.

The choking game

5.7% of eighth-graders had participated in the self-strangulation activity known as "the choking game". Recognize signs of these activities: bruising or red marks on the neck; wearing high-necked shirts, even in warm weather; bloodshot eyes or pinpoint bruising around the eyes; petechiae on the face, especially the eyelids or conjunctiva.

HPV vaccine

The US Food and Drug Administration (FDA) approved the use of quadrivalent human papillomavirus vaccine in males aged 9 through 26 years to reduce their likelihood of acquiring genital warts.

13-valent PCV

The FDA approved a 13-valentpneumococcal conjugate vaccine (PCV13). PCV13 adds serotypes 1, 3, 5, 6A, 7F, and 19A to those contained in the PCV7, the 7-valent vaccine (4, 6B, 9V, 14, 18C, 19F, and 23F). The six additional serotypes accounted for 63% of invasive pneumococcal disease among children younger than five years of age.

References:
What's new in pediatrics. UpToDate.

Image source: OpenClipArt.org, public domain.

Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook.


Video Lecture: Anne Wojcicki from 23andMe Personal Genomics

Direct link here.

23andMe is a personal genomics company based in Mountain View, California that is analyzes saliva samples for genetic information (the average cost for the service is decreasing and is currently $399-$499).

The company name is a play on the 23 pairs of chromosomes that carry every individual’s DNA. 23andMe was co-founded by Anne Wojcicki, wife of Google co-founder Sergey Brin.


"Genes load the gun. Lifestyle pulls the trigger" - Dr. Elliot Joslin.

Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook.


Glycated hemoglobin as a diagnostic test for diabetes predicts mortality more accurately than fasting glucose

Fasting glucose is the standard measure used to diagnose diabetes in the United States. Recently, glycated hemoglobin was also recommended for this purpose.

The glycated hemoglobin value at baseline was associated with newly diagnosed diabetes and cardiovascular outcomes.

For glycated hemoglobin, values of less than 5.0%, 5.0-5.5%, 5.5-6.0%, 6.0-6.5%, and 6.5% or greater, the hazard ratios for diagnosed diabetes were 0.52, 1.00, 1.86, 4.48, and 16.47, respectively.

For coronary heart disease, the hazard ratios were 0.96, 1.00, 1.23, 1.78, and 1.95, respectively. The hazard ratios for stroke were similar.

In contrast, glycated hemoglobin and death from any cause were found to have a J-shaped association curve.

The association between the fasting glucose levels and the risk of cardiovascular disease or death from any cause was not significant.

In this community-based population of nondiabetic adults, glycated hemoglobin was associated with a risk of diabetes and more strongly associated with risks of cardiovascular disease and death from any cause as compared with fasting glucose. These data add to the evidence supporting the use of glycated hemoglobin as a diagnostic test for diabetes.

References:

Image source: OpenClipArt.org, public domain.

Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook.


People behaved more selfishly and dishonestly when working in a dimly lit room or when wearing sunglasses

Researchers found that people working in a dimly lit room were more likely to cheat about their own performance on a task in order to earn more money than people working in a well-lit room.

Darkness may create a sense of illusory anonymity that disinhibits self-interested and unethical behaviors. It appears to induce a false sense of concealment, leading people to feel that their identities are hidden.

References:
Dim Lighting and Sunglasses Encourage Unethical Behavior in Study. WebMD.
Image source: Ray Ban Original Wayfarer, Wikipedia, Creative Commons Attribution-Share Alike 3.0 Unported license.

Comments from Twitter and Facebook:

@scanman: RT @DrVes: when working in a dimly lit room http://goo.gl/fb/erLEf

@doctorwhitecoat: Clubbing/bars? RT @DrVes People behaved more selfishly/dishonestly when in a dimly lit room or when wearin sunglasses http://goo.gl/fb/erLEf

Mike Cadogan: "Recently started working in the office with the light on...feeling better and more energetic already, though not sure about the selfish/dishonest part..."

Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook.


Skull Cake

skull chocolate cake

skull chocolate cake

skull chocolate cake

Thanks to Dlisted for linking to this awesome skull cake. theCHIVE (go to their site for more pictures) just put up pictures, so I don’t know who made it. Either way it looks delicious. I would want mine with a nice gelatinous filling.