Myers: Kurzweil is a "pseudo-scientific dingbat" who "does not understand" the brain

Biologist and skeptic PZ Myers has ripped into Ray Kurzweil for his recent claim that the human brain will be completely modeled by 2020 (Note: Not that it's particularly important, but Kurzweil did say it'll take two decades at the recent Singularity Summit, not one). In a rather sweeping and insulting article titled, "Ray Kurzweil does not understand the brain," Myers takes the position that the genome cannot possibly serve as an effective blueprint in our efforts to reverse engineer the human brain.

In regards to he claim that the design of the brain is in the genome, he writes,

Kurzweil knows nothing about how the brain works. It's [sic] design is not encoded in the genome: what's in the genome is a collection of molecular tools wrapped up in bits of conditional logic, the regulatory part of the genome, that makes cells responsive to interactions with a complex environment. The brain unfolds during development, by means of essential cell:cell interactions, of which we understand only a tiny fraction. The end result is a brain that is much, much more than simply the sum of the nucleotides that encode a few thousand proteins. He has to simulate all of development from his codebase in order to generate a brain simulator, and he isn't even aware of the magnitude of that problem.

We cannot derive the brain from the protein sequences underlying it; the sequences are insufficient, as well, because the nature of their expression is dependent on the environment and the history of a few hundred billion cells, each plugging along interdependently. We haven't even solved the sequence-to-protein-folding problem, which is an essential first step to executing Kurzweil's clueless algorithm. And we have absolutely no way to calculate in principle all the possible interactions and functions of a single protein with the tens of thousands of other proteins in the cell!

Myers continues:

To simplify it so a computer science guy can get it, Kurzweil has everything completely wrong. The genome is not the program; it's the data. The program is the ontogeny of the organism, which is an emergent property of interactions between the regulatory components of the genome and the environment, which uses that data to build species-specific properties of the organism. He doesn't even comprehend the nature of the problem, and here he is pontificating on magic solutions completely free of facts and reason.

Okay, while I agree that Kurzweil's timeline is ridiculously optimistic (I'm thinking we'll achieve a modeled human brain sometime between 2075 and 2100), Myers's claim that Kurzweil "knows nothing" about the brain is as incorrect as it is disingenuous. Say what you will about Kurzweil, but the man does his homework. While I wouldn't make the claim that he does seminal work in the neurosciences, I will say that his efforts at describing the brain along computationally functionalist terms is important. The way he has described the brain's redundancy and massively repeating arrays is as fascinating as it is revealing.

Moreover, Myers's claim that the human genome cannot inform our efforts at reverse engineering the brain is equally unfair and ridiculous. While I agree that the genome is not the brain, it undeniably contains the information required to construct a brain from scratch. This is irrefutable and Myers can stamp his feet in protest all he wants. We may be unable to properly read this data as yet, or even execute the exact programming required to set the process in motion, but that doesn't mean the problem is intractable. It's still early days. In addition, we have an existing model, the brain, to constantly juxtapose against the data embedded in our DNA (e.g. cognitive mapping).

Again, it just seems excruciatingly intuitive and obvious to think that our best efforts at emulating an entire brain will be informed to a considerable extent by pre-existing data, namely our own DNA and its millions upon millions of years of evolutionary success.

Oh, and Myers: Let's lose the ad hominem.

Parasitic wasps on Weeds: We have video! | The Loom

Thanks to Mandarb for posting this clip from Weeds I was wondering about yesterday. I should point out that it’s a very abridged version of my original piece on the radio. For example, it sounds as if I’m giving God my own personal forgiveness for parasitic wasps. I was actually talking about a letter written by Darwin in which the wasps figured in his musings about God.

And I have to say that I’m not much closer to figuring out what parasitic wasps have to do with the show’s plot. I guess I’ll have to watch the whole episode. But–for the record–here it is:


Don’t Be a Dick, Part 1: the video | Bad Astronomy

[Note: As is obvious by the title, the article below contains mildly NSFW language.]

In July, I spoke at The Amaz!ng Meeting 8 in Las Vegas. Sponsored by the James Randi Educational Foundation, it’s the largest meeting of critical thinkers and skeptics in the world. Unlike my usual talks about the abuse of science that I had given at previous TAMs, this time I wanted to tackle a much thornier issue: how we skeptics argue with believers of various stripes.

My first point was that we must keep in mind our goal. If it’s to change the hearts and minds of people across the world, then at least as important as what we say is how we say it. And my second point was pretty simple… but you’ll get to it around 24 minutes in. It’s obvious enough.

Here’s the video. The whole thing is about a half hour long.

Phil Plait – Don’t Be A Dick from the James Randi Educational Foundation.

I’ll admit I was pretty nervous about this talk, as I was basically telling people to be nicer. It’s hard for some people to hear a message like that, and I knew there would be backlash. There was. I have heard from quite a few people about the talk, as you might expect. They fell into three basic categories: some agreeing with me, others saying being dick has its place, and still others who misinterpreted what I was saying.

I’ll post links to copious blog articles on all sides of this issue a bit later, but I want to clear a few things up here first.

Some people are claiming I was saying we need to be milquetoasts. That’s ridiculous. I was very clear that anger has its place, that we need to be firm, and that we need to continue the fight.

Some were claiming they have a right to be dicks — I’m bemused by this, as of course you have that right. But that doesn’t mean it’s most effective, or that you should be one.

Others took issue with my initial question, asking how many people were "converted" to skepticism by having a skeptic yelling at them and insulting them. In fact, at least one person said that method does work and worked on them. That’s good for them, but given what we know about the way people argue and change their views on issues, the vast majority of people will become further entrenched when confronted in that way.

In other words, being a dick not only usually doesn’t work, it almost always works against the bigger goal of swaying the most people we can.

Perhaps I should have been more clear on what I mean by being a dick. I thought I had been clear, but a lot of people seem to think that I meant anyone who gets upset, or angry, or argues with emotion. I wouldn’t include satire in that category, or comedic work, or even necessarily using insults; tone and attitude count here. Think of it this way: when someone argues that way do you think to yourself, "What a dick"? I don’t; at least not necessarily. I think that way when the person belittles their opponent, uses obviously inflammatory language, or overly aggressively gets in their face.

Y’know. Being a dick.

Again, to be clear, I did not say we should back down when confronted. I did not say we should be weak against ignorance. I did not say we shouldn’t be angry. I did not say we should be passionless.

In fact, I argued the exact opposite. We need our anger, or strength, and our passion.

And one last point: a lot of folks were speculating that in my talk I was targeting specific people such as PZ Myers, Richard Dawkins, even Randi himself. I wasn’t. I was thinking fairly generically when I wrote the talk, and though I did have some specific examples of dickery in mind, the talk itself was not aimed at any individual person. In fact, though the basis of the talk was due to the degradation in tone I’ve been seeing lately (and I’m not at all alone in seeing it), it was also something of a confessional. Like most skeptics, at some points — too many, I now feel — in the past I’ve been a dick. I regret those times, and will strive to make sure they stay in the past.

So no, the talk was not aimed at any specific individuals. It was aimed at everyone, everywhere, and also inward toward myself. I cannot accuse others of that which I have not at the very least searched for in myself. And I have indeed found it in myself, which was the final factor in my making the speech in the first place.

I can’t promise that I won’t be a dick. But I will strive mightily to try. That’s the most I can do, and the most I can ask of anyone.

[Note: There are two more parts of this saga coming up soon, including links to many and diverse opinions on what I said, and the talk's aftermath.]


Wiring a 110 VAC Vicker Coil Pack

Can anyone help me Have a directional hydraulic valve with two Vicker P/N 633741 coil packs 110 VAC. They have two leads from each coil. How do I wire them up? The coils operate opposing each other to control hydraulic flow forward neutral reverse inside a valve body. I would like to use

Nanoscale DNA sequencing to spur revolution in personal health care

Researchers at the University of Washington have devised a method that works at a very small scale to sequence DNA quickly and relatively inexpensively. The process could eventually open the door for more effective individualized medicine. It's hoped that the method will, among other things, provide blueprints of genetic predispositions for specific conditions and diseases such as cancer, diabetes or addiction.

"The hope is that in 10 years people will have all their DNA sequenced, and this will lead to personalized, predictive medicine," said Jens Gundlach, a UW physics professor and lead author of a paper describing the breakthrough.

The technique creates a DNA reader that combines biology and nanotechnology using a nanopore taken from Mycobacterium smegmatis porin A. The nanopore has an opening 1 billionth of a meter in size, just large enough to measure a single strand of DNA as it passes through.

The research team placed the pore in a membrane surrounded by potassium-chloride solution and a small voltage was applied to create an ion current flowing through the nanopore. The current's electrical signature changed depending on the nucleotides traveling through the nanopore. Each of the nucleotides that are the essence of DNA (namely cytosine, guanine, adenine and thymine) produced a distinctive signature.

The delay is measured in thousandths of a second, which is long enough to read the electrical signals from the target nucleotides. "We can practically read the DNA sequence from an oscilloscope trace," said Gundlach.

The work was funded by the US National Institutes of Health and its National Human Genome Research Institute as part of a program to create technology to sequence a human genome for $1,000 or less. That program began in 2004, when it cost on the order of $10 million to sequence a human-sized genome. The new research is a major step toward achieving DNA sequencing at a cost of $1,000 or less.

Ultimately, it is hoped that these experiments will outline a novel and fundamentally very simple sequencing technology that can now be expanded into a mechanized process.

Craftsman Lathe (Need Help Please)

I have a family member that has a Craftsman Lathe model 101.27440 it is an older model. She is needing to sell it along with all the attachments. I would love to buy it from her and I know she won't get what it's probably really worth due to its age (guessing over 50 years old, if not more). It d

For the Aging, Four-Eyed Astronaut: Fancy Space Bifocals | Discoblog

glassesOne of the requirements for flying in a spaceship used to be near-perfect vision. When NASA relaxed its vision standards (to 20/200 or better uncorrected, correctable to 20/20 each eye for a mission specialist) they in turn created a new requirement–for near-perfect astronaut eyeglasses.

TruFocals (made by Zoom Focus Eyewear, LLC) might improve current astronaut spectacles by allowing space-travelers to focus mid-float on both near and far objects, whether they’re dealing with experiments or cooling loop warning indicators. As Scientific American reports, the glasses are currently undergoing NASA evaluation for space readiness–tests that include burning. The lenses will correct the condition known as presbyopia, in which aging people’s eyes lose focusing ability, making it difficult to see near objects. That’s the condition that causes people with good eyes to pick up reading glasses, and those with glasses to turn to bifocals.

These space glasses aren’t much like your grandma’s bifocals. TruFocals have two lenses for each eye: the outer lens uses the person’s usual prescription and the inner lens (closer to the the eye) is flexible and controllable by a slider on the eyeglasses’ bridge. With a little slide the shape of the inner lens changes, allowing the wearer to adjust their focus. That could be handy in an environment like the International Space Station, where floating astronauts may be trying to focus on things from odd angles.

The round shape is a necessity for the glasses to work best, Stephen Kurtin the glasses’ inventor told Scientific American, not a fashion decision:

“Some people say they’re cool, and some say they’re butt ugly.”

NASA may approve the glasses in time for the next space mission, though, as shown in the target-practice video below, the lenses are already available for planet dwelling four-eyes.

Related content:
Discoblog: E-focals: Electric Eyeglasses Are the New Bifocals
Discoblog: Cheap “Liquid Glasses” Bring Clear Vision to the Poor
Discoblog: Contacts Claim to Fix Your Vision While You Sleep
Discoblog: Will the Laptops of the Future Be a Pair of Eye Glasses?
Discoblog: Possible Cure For Blindness: Implanting a Telescope in Your Eye

Image: ZOOM FOCUS EYEWEAR LLC


Four Contributions of Molybdenum to Steel

By retarding transformation rates, molybdenum improves the hardenability of its alloy steel grades.

Believe it or not, its name is from the Greek word for lead.

Molybdenum is an essential micronutrient, but large doses can be highly toxic. Fortunately, we don't eat our all

Ethyl Acetate Vaporization

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When the RH is increase then lamination quality is low that mean there are bubbles. because of present of un-vaporize Ethyl acetate. Adhesive made by ADCOTE,CATALYST F-845, and ethyl acetate.