Learning from Werner Syndrome

Accelerated aging conditions may result from individual aspects of “normal” aging run wild and out of control. This means we can potentially learn more about those mechanisms. For example: “a gene shown to play a role in the aging process appears to play a role in the regulation of the differentiation of embryonic stem cells. … researchers identified a protein interaction that controls the silencing of Oct4, a key transcription factor that is critical to ensuring that embryonic stem cells remain pluripotent. The protein, WRNp, is the product of a gene associated with Werner syndrome, an autosomal recessive disorder hallmarked by premature aging. … We showed that the depletion of WRNp blocked the recruitment of Dnmt3b to the Oct4 promoter, and resulted in reduced methylation. The reduced DNA methylation was associated with continued Oct4 expression, which resulted in attenuated differentiation. … These results reveal a novel function of WRNp, and demonstrate that WRNp controls a key step in pluripotent stem cell differentiation. Our data support the emerging hypothesis that attenuated stem cell differentiation is involved in aging. This lack of differentiated cells may contribute to failure to maintain organ or tissue function in the later stages of life.”

View the Article Under Discussion: http://sify.com/news/aging-related-gene-plays-role-in-stem-cell-differentiation-news-international-kgfnOiabcdj.html

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Allen Human Brain Atlas Launched

While we’re on the subject of the importance of the brain to engineered longevity, here is news of an infrastructural advance from EurekAlert!: “The Allen Institute for Brain Science announced today that it has launched the Allen Human Brain Atlas, a publicly available online atlas charting genes at work throughout the human brain. The data provided in this initial data release represent the most extensive and detailed body of information about gene activity in the human brain to date, documenting which genes are expressed, or ‘turned on’ where. In the coming years, the Atlas will be expanded with more data and more sophisticated search, analysis and visualization tools to create a comprehensive resource useful to an increasingly wide range of scientists and research programs worldwide. The Allen Human Brain Atlas, available at http://www.brain-map.org, is a unique multi-modal atlas of the human brain that integrates anatomic and genomic information to create a searchable, three-dimensional map of gene activity in the brain. Data modalities in this resource include magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) and histology – providing information about gross neuroanatomy, pathways of neural connections, and microscopic anatomy, respectively – as well as gene expression data derived from multiple approaches.”

View the Article Under Discussion: http://www.eurekalert.org/pub_releases/2010-05/aifb-aif052410.php

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

The Logical Endpoint of Neuroinformatics

Here is a presentation given by researcher Anders Sandberg for Google’s Tech Talk series: “The idea of creating a faithful, one-to-one computer copy of a human brain has been a popular philosophical thought experiment and science fiction plot for decades. While computational neuroscience and systems biology are currently very far away from this goal, the trends towards large-scale simulation, industrialized neuroinformatics, new forms of microscopy and powerful computing clusters point in this direction and are enabling new forms of simulations of unprecendented scope. In this talk I will discuss current estimates of how close we are to achieving emulated brains, technological requirements, research challenges and some of the possible consequences.” A little while back the Future of Humanity Institute published a roadmap to whole brain emulation. This topic is of interest to supporters of engineered longevity as a part of the very long term goal of incrementally replacing the vulnerable biology of the brain with something more robust and damage-resistant. Such as, for example, clusters of diamondoid nanomachines designed to emulate the functions of neurons.

View the Article Under Discussion: http://www.aleph.se/andart/archives/2010/06/whole_brain_emulation_the_logical_endpoint_of_neuroinformatics.html

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Eat Less, Live Longer

The New Scientist on calorie restriction: “Dreams of eternal youth feature in many cultures throughout history, but it was only in the 20th century that research into longevity really began. Much about ageing is still mysterious – we don’t even know the underlying reasons why we journey into old age. There are many lines of enquiry into how to live longer, though, with one of the most intriguing being calorie restriction: in effect, going on a lifelong diet. Calorie restriction dramatically extends not only the lifespan of laboratory animals, but also their ‘healthspan’ – how long they live free of disease. On the assumption that it has the same effect in people, some individuals have already adopted a restricted diet. The latest evidence suggests that while calorie restriction is indeed beneficial for humans, when it comes to lifespan extension, it may not be the whole story. The good news is that we might be able to delay ageing without cutting our food intake. … There’s a definite possibility that if you balance the diet correctly, a longer lifespan can be achieved without full food restriction. … It is unclear why eating less should make animals live longer. While a restricted diet triggers numerous changes at the molecular and genetic levels, only some of these are common across all the species tested. However, there does seem to be a general principle that a dearth of nutrients causes organisms to divert resources away from growth and reproduction and towards basic survival functions. From an evolutionary perspective, these adaptations could help an organism survive famine.”

View the Article Under Discussion: http://www.newscientist.com/article/mg20627621.100-eat-less-live-longer.html?full=true

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Secular Humanists and Apologism for Death

From Depressed Metabolism: “Some contemporary atheists and secular humanists do not stop at debunking the idea of God but seem to think that making a persuasive case against religion requires them to refute all of its associated ideas as well; including the desire for immortality. Paula Kirby is not the first secular person praising our limited lifespan and glorifying death: ‘For atheists it is the very transience of life that helps to give it its meaning: for it prompts us to live it to the full’ … Kirby does not just repeat the hollow non-empirical cliche that life can only have meaning in the face of death but she also pretends to speak on behalf of all atheists. As can be expected, she cannot imagine an extremely long lifespan to be anything else than unspeakable boredom. When she writes that ‘Susan Ertz got it spot on with her witty remark that millions yearn for immortality who don’t know what to do with themselves on a rainy Sunday afternoon’ one cannot help thinking that she is conveying more information about herself and Susan Ertz than about humans in general. … It is remarkable to what extent the notion of death as not only biological but ontological necessity has permeated Western philosophy – remarkable because the overcoming and mastery of mere natural necessity has otherwise been regarded as the distinction of human existence and endeavor.”

View the Article Under Discussion: http://www.depressedmetabolism.com/2010/05/25/humanist-death-apologetics/

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Vitalaâ„¢ Continence Control Device Receives Gold Award for Medical Design … – PR Newswire (press release)

Vitala™ Continence Control Device Receives Gold Award for Medical Design ...
PR Newswire (press release)
The 2010 Medical Design Excellence Awards (MDEA) were announced at a presentation ceremony yesterday in New York City's Jacob K. Javits Convention Center, ...
Vitala™ CCD (Continence Control Device) by ConvaTecInventorspot

all 8 news articles »

Wayne Root hearts fellow Tea Partier Sharron Angle

Republican-leaning Libertarian Wayne Allyn Root of Nevada, has a glowing editorial on his blog, extolling the win of Tea Party insurgent Sharron Angle over her GOP rivals Danny Tarkanian, and Sue Lowden.

Root asks "U.S. Senator Sharron who?" (RootforAmerica):

I TOLD YOU SO! The question on national political experts minds Wednesday morning is, “Sharon who?” Sharon Angle was the winner of the Republican U.S. Senate primary in Nevada. Few on the national scene saw this coming. But I did. As a Nevada Reagan Libertarian, Tea Party activist, and national political commentator, I’ve said for months that in a “Tea Party year” anything is possible- including the election of a political outsider like Sharon Angle.

When the public is angry and wants blood- all bets are off. Ask Utah Senator Bennett and Pennsylvania Senator Arlen Specter. Ask the voters of Massachusetts, Virginia and New Jersey, who all participated in big wins for maverick underdog candidates in the past year. Ask Nevada Governor Jim Gibbons, the first sitting governor ever defeated in a primary in Nevada history (also last night). Ask Arkansas Senator Blanche Lincoln who barely escaped with her life on Tuesday, only to face sure defeat in the general election in November. Ask the Lt. Governor of South Carolina, who got 17% of the vote against an unknown female candidate (Nikki Haley) endorsed by Sarah Palin. The new mantra is V.E.T.O.- Vote Everyone of Them Out!

Nevada is the canary in the coalmine. I predict all over this country the media will be stunned by this “new world order.” Conservative and Libertarian are back in vogue; “traditional” and “establishment” are dirty words; and radical is the new mainstream. The Reids (Harry and his son Rory) are in the wrong place, at the wrong time. All you have to do is “read the tea leaves” to know that. In this new world order, Sharron Angle may be just what the doctor ordered.

Root was recently elected to the Libertarian National Committee. He is a regular speaker on the Tea Party circuit and joined with Sarah Palin at the huge rally held in April in the Nevada desert to oppose Reid, sponsored by Tea Party Express.

Sharron Angle has some explaining to do before she gains full Libertarian Republican support

Is she really anti-Beer?

by Eric Dondero

Readers of Libertarian Republican may wonder why we have not highlighted the campaign of Tea Party-aligned candidate for US Senate Sharron Angle in Nevada. She is now the official GOP nominee against Harry Reid. She beat both Sue Lowden and Danny Tarkanian soundly, yesterday in the Nevada Republican primary.

She's solid on economics. In fact, 100% libertarian on taxes and spending issues, which has won her the label of "extremist" from the liberal media.

However, there are disturbing facts about her on the social side. And while Libertarian Republicans often look past social conservatives who emphasize fiscal conservativism, in Angle's case it may be too much to ignore.

From Steve Sebilius, Slash Politics blog, May 24:

Back in 2006, Angle gave an interview to the excretable execrable (and now defunct) Liberty Watch magazine, which covered politics when it wasn’t extolling the virtues of corrupt state senators, providing a forum for racist rants or profiling 9/11 Truthers. And that interview provides a little more insight into Angle’s conservatism.

Liberty Watch’s website isn’t up on the Internets any longer, but a version of the interview is helpfully posted on the website of the Republican Majority Campaign PAC. Here’s the relevant passage, from a discussion about medical marijuana:

“My greatest problem with marijuana is that it’s illegal, which gives Nevadans a false sense of security in this whole thing,” Angle said. “If the DEA has the manpower and wanted to go after this, there is no place in Nevada state law that can protect people because federal law supersedes state law.”

Her opinion, though, ignores states’ rights and individual freedom. Also, Angle’s faith quickly surfaced, extinguishing her argument that she disapproves of medical marijuana primarily on the elementary premise that it’s illegal.

“I would tell you that I have the same feelings about legalizing marijuana, not medical marijuana, but just legalizing marijuana,” Angle offered. “I feel the same about legalizing alcohol.

“The effect on society is so great that I’m just not a real proponent of legalizing any drug or encouraging any drug abuse,” she continued. “I’m elected by the people to protect, and I think that law should protect.”

Wait, what? Alcohol — which is currently legal — should be treated the same as marijuana — which is currently not legal? Is she serious? A candidate from the state of Nevada, which is practically sponsored by booze companies, is not a proponent of legal alcohol?

Make no mistake about it, we are 100% Pro-Beer at Libertarian Republican.

It goes without saying that Angle is by far the preferred candidate in the voting booth by anyone who cherishes liberty, over monstrous liberal Reid. However, the question is, how much are Libertarian Republicans willing to walk precincts for her, or give her campaign donations, or make phone calls on her behalf in the coming months. If she takes the time to address this "beer issue," and clarifies her views, that she's not in favor of any sort of prohibition, that she just finds it distasteful personally, she may find the libertarian wing of the GOP excited about her candidacy. If she moves on and leaves it hanging, she'll still win Libertarian Republican votes, but most assuredly not active support.

"Chris Christie Republican" Anna Little overcomes enormous odds to win

From Eric Dondero:

Bruce Springsteen's next Representative in Congress for his hometown district could be a Republican?

From the Asbury Park Press, last night:

In the 6th District, Republican conservative and Highlands Mayor Anna C. Little, a favorite of the Tea Party movement, challenged wealthy businesswoman and party fundraiser Diane Gooch for the chance to run against incumbent Democratic Rep. Frank Pallone.

By midnight, Little, who is also a former Monmouth County freeholder, held a 6,725-to-6,662 lead over Gooch, the owner and publisher of The Two River Times.

Little was outspent by Gooch $492,000 to $22,000.

Very latest numbers with 100% of the precincts reporting (minus outstanding provisional ballots), has Little ahead by 103 votes. The Gooch campaign is giving signals that they will call for a re-count.

Too much Government, and way too many Bureaucrats

New from Dan Mitchell of the Cato Institute

America has too many bureaucrats and they are dramatically overpaid. This mini-documentary uses government data to show how federal, state, and local governments are in fiscal trouble in part because of excessive pay for a bloated civil service.

BREAKING NEWS!! Geert Wilders best ever showing for his Party in Dutch Elections

24 Seats in Parliament for Party For Freedom

From Eric Dondero:

We'll have full details tomorrow. But the news out of the Netherlands is about as good as it gets for Right Libertarians.

Both parties favored by Libertarian Republican Geert Wilders Party of Freedom, and Mark Rutte's pro-business People's Party (VVD) did exceptionally well. In fact, it appears that Rutte may be able to assemble a coalition on the Right to lead the Government.

From the AP:

AMSTERDAM — An anti-Islam party notched large gains in Dutch elections on Wednesday, but a contest between the two largest parties on the right and left remained too close to call.

With 91 percent of votes counted, the pro-business VVD party led Labor by 31 seats to 30 in the 150-seat parliament, a result that spelled weeks and possibly months of haggling to fashion a ruling coalition among parties deeply split on immigration and how to curb government spending.

The anti-Islam Freedom Party of Geert Wilders scored its best-ever finish with 24 seats.

Although not as outspoken against immigration as Wilders, Rutte has also argued that immigrants who cannot contribute to the Dutch economy should not be allowed to come, and he would ban them from receiving welfare for 10 years after arrival.

Editor's Note - Cliff Thies will have a full election analysis tomorrow here at LR.

Nikki’s Victory a Win for the "Libertarian/Sarah Palin wing"

"Libertarian" with a Capital 'L'

Nikki Haley finished with 49% of the vote in the GOP primary last night. Her nearest rival gained 22%, which makes the outcome of any run-off all-but-certain.

Her huge win is being heralded, even by the liberal media, as a victory for libertarians and most especially for libertarian-leaning kingmaker Sarah Palin.

From Google News via the AP "Haley weathers tryst accusations in SC gov race":

COLUMBIA, S.C. — South Carolina's Nikki Haley entered a runoff for the Republican gubernatorial primary with a substantial edge over her GOP rival, deflecting attacks on her marriage and her ethnicity using an antiestablishment message that resonated with the state's voters.

"We saw us push against the establishment, we saw us push against the power and push against the money and boy did they push back," Haley, a three-term state lawmaker and tea party headliner, said after coming close to winning the four-way race outright.

Continuing:

Haley blamed an entrenched "Good Old Boy" system for conspiring to derail a campaign that gained steam with a slew of television ads and a spirited endorsement by former Alaska Gov. Sarah Palin. She pivoted off the claims to underscore an antiestablishment message that has so far resonated.

Haley's politics are familiar to the state's conservative voters. She hews to the Libertarian, limited government policies favored by Sanford, though she distanced herself from him. He backed her candidacy and she won the endorsement of his ex-wife, popular former first lady Jenny Sanford.

Maine gets a Republican for Governor who may be "more of a Libertarian"

Under the Radar Election

“We’re seeing our taxes go up and our freedoms eroded. The government is putting the shackles of economic slavery to each and every one of us. The Maine taxpayer has been put at an extreme disadvantage.” -- Paul LePage

He's been described as the "Tea Party candidate," and even "Far Right." He is the Mayor of Waterville, a working class town in the southeast coast. He has an entirely Democrat city council.

From the Bangor Daily News:

In Waterville, LePage lowered taxes 13 percent in six years, improved the city’s credit rating and increased the rainy day fund from $1 million to $10 million...

Continuing:

“I’ve heard that some people think I’m a nutcase or some kind of wacko conservative extremist,” said LePage during a recent interview at Waterville City Hall. “If those accomplishments are what makes a wacko, then I’m a wacko. I’m a fiscal conservative, and I’m not ashamed of it.”

Now this morning this description from RedDiva's Drivel, primary relection round-up:

The Democratic Primary winner, State Senator Elizabeth Mitchell, will face the Republican Primary winner, Paul LePage who is more Libertarian than Republican, and three Independent candidates in November.

He won a crowded primary field last night, with 8 candidates.

REPUBLICAN

Paul LePage – 20,393 (37.7%)

Les Otten – 9,302 (17.2%)

Peter Mills – 7,465 (13.8%)

He also leans libertarian on social matters. From the Bangor Daily News, June 9:

Casinos also trigger the debate between the libertarian perspective and the view that government must protect people from their worst instincts.

The casino question is instructive for voters weighing the candidates...

On the hot issue of a proposed Casino in Oxford County, continuing:

Paul LePage said he was conflicted, but supported it.

LePage was endorsed by the Republican Liberty Caucus. According to Pine Tree Politics (a libertarian-leaning Republican website) former State Rep. and current ME RLC Chair Ken Lindell sent out a "Liberty Compact" to all the GOP primary candidates asking them to sign. Three of them, including LePage, signed it. It reads as follows:

“I (name), pledge to the citizens of the State of Maine and to the American people that, as their elected representative I will work to:

Restore liberty, not restrict it; shrink government, not expand it; reduce taxes, not raise them; abolish programs, not create them; promote the freedom and independence of citizens, not the interference of government in their lives; and observe the limited, enumerated powers of our Constitution, not ignore them.”

LePage also won the all-important straw poll at the recent GOP State Convention.