More on DAF-16 and Longevity in Nematodes

The DAF-16 gene in nematode worms such as C. elegans is thought to be the fulcrum of a metabolic feedback loop that switches between long-lived stress resistant and short-lived reproduction focused states. “Ageing is a process that all organisms experience, but at very different rates. We know that, even between closely related species, average lifespans can vary enormously. We wanted to find out how normal ageing is being governed by genes and what effect these genes have on other traits, such as immunity. To do that, we looked at a gene that we already knew to be involved in the ageing process, called DAF-16, to see how it may determine the different rates of ageing in different species. … Researchers compared longevity, stress resistance and immunity in four related species of worm. … They also looked for differences in the activity of DAF-16 in each of the four species and found that they were all quite distinct in this respect. And, importantly, the differences in DAF-16 corresponded to differences in longevity, stress resistance and immunity between the four species – in general higher levels of DAF-16 activity correlated with longer life, increased stress resistance and better immunity against some infections.”

View the Article Under Discussion: http://www.bbsrc.ac.uk/media/releases/2010/100401-ageing-gene-found-to-govern-lifespan.aspx

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

The Long Road Towards Prosthetic Nerves

One day, it will be possible to replace nerves with entirely artificial conduits. This is a branch of medical technology that will compete with regenerative medicine, and ultimately lead to more effective and resilient body parts. But today, the foundations are still being designed. A long road lies ahead. Here, the New Scientist looks at early work: “Schiefer is describing an experiment in which pulses of electricity are used to control the muscles of an unconscious patient, as if they were a marionette. It represents the beginnings of a new generation of devices that he hopes will allow people with paralysed legs to regain control of their muscles and so be able to stand, or even walk again. His is one of a raft of gadgets being developed that plug into the network of nerves that normally relay commands from the spinal cord to the muscles, but fall silent when a spinal injury breaks the chain. New ways to connect wires to nerves [allow] artificial messages to be injected to selectively control muscles just as if the signal had originated in the brain. Limbs that might otherwise never again be controlled by their owners can be brought back to life. … Nerves contain tens of thousands of axons, each capable of being controlled by the ultimate puppeteer: the brain. Learning to pull even a few of those strings, though, could restore partial function to a person’s limb, restoring some control to an arm or leg that was previously paralysed.”

View the Article Under Discussion: http://www.newscientist.com/article/mg20627546.200-paralysed-limbs-revived-by-hacking-into-nerves.html?full=true

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Twitter: Less Time, more Benefit–with Paper.li

If you’re like me, you started out spending a lot of time on Twitter, mostly trying to figure out how to use it effectively. You’ve probably been using Hootsuite or Tweetdeck or some other productivity tool.
Then you realized Twitter was sucking up your life. So you decided to limit your time on Twitter. Unfortunately you [...]

Nowadays the Nike Shox

Shox are made up of safe rubber and have small hollow columns that makeup the midsole of the shoe. All kinds with open series of the midsole in dead 2000 the Nike Shox runner the BB4 basketball shoe and for GYM purposes as the shox are precise use for running casual friction and the XT4 crossschooling shoe. The first shoes to use the bank of varieties.A Nike Aired Max shoe customs a larg

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A couple of weeks into our stay in India we had been asked to travel to the region of Ladakh a fascinating former Buddhist kingdom in the far north to join a luxury trek and then write an article about it for a UK magazine. We happily agreed to the commission and then settled into the beaches of Goa to wait for our instructions about when to travel north reasoning that there was no point in tr

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Barmer TourismBarmer is a desert town just 153 kms from Jaisalmer and has fortresses to boast off. This place is primarily famous for its woodcarving furniture and interiors carpets block printing and embroideries.The centre for embroidery is the Sadar Bazaar and woodcarvings are around the Station Road. It has an RTDC Hotel and private Hotels too.Just 35 kms form Barmer is a group of five temp

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Greetings one and allWell once again I have been lazy on the blogging front and literally a few people have been crying out for another blog entry so I better give the minority what they wantI have a lot to write about and I am feeling a bit jittery as I just got an electric shock from the USB port of the computer i'm on but I will try my hardest.Following on from Siem Riep I decided to head to

The Venitian Hotel

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Frida Giannini said When I started to argue the idea of concept with Mark I knew that we piece the same idea. It's genuinely exciting. He has the fanatical point brains and a vivid annals of sports shoes. He is a great artist who has obstructcultural and irritabletime influences.Giannini paints its Gucci outletTEMPORARY stock dazzling white decorating with red and green belts creating an

On Love and Loss

We've had a hectic wonderful and at times bittersweet past few days. I'm reminded daily of the blessings that God has given me in my life and I strive to never let a day go by that I don't say thank You. Terri's great aunt passed away several days ago. She was the first nurse in the family and Terri's first choice to pin her at nursing school graduation but because of her advanced age and dete

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Hi to all our family and friends as we said in our last blog we are going to post a few of our pictures from the trip to Beijing so please enjoy the photos we took from Tian'anmen Square Chinese Parliament buildings and some old and some new markets streets.