JVC’s Updated $800 Audiophile Wooden Earphones [Earphones]

JVC has updated their original wooden headphones by slashing their price as well as their size. The company claims the wood construction gives the earphones superior sound quality, in addition to superior style.

While the original cans went for nearly $800, the JVC HA-FX700 will come with a $330 price tag. Though the price is steep, you're paying for undeniably pretty earphones, purportedly high sound quality, and a lot of little parts:

The JVC HA-FX700 will be available in Japan in February and likely obtainable through your preferred Japanese electronics importer. [CrunchGear]



Lp(a) Maybe there’s something there that wasn’t there before?

I unwrapped the NEJM this week and to my surprise it has a Lp(a) stuff in it. One of the things we do to prevent heart disease is take family histories. We also check cholesterol levels and include something called a Cardio-CRP. One thing we haven't been including is a Lp(a). Why? The only data I see that is good on this is on women.


We use validated risk tools like Reynolds and Framingham Risk. It was with great interest that I read about this recent "candidate gene" model of assessment for Lp(a) genetic link to levels and risk. Clarke et. al.

They also looked at the other GWAS linked regions and what they found was most surprising in my mind.

LPA, which encodes apolipoprotein(a), was the only true "candidate" gene on this custom array that was significantly associated with coronary disease.

Now why would the other regions not be as strongly linked? Or better yet, why was Lp(a) more likely to be linked and associated?

Well, LPA the gene produces a protein called Lp(a) which is hypothesized to carry oxidized proinflammatory phospholipids, thus promoting inflammation in coronary arteries in turn creating niduses for clot and heart attack.

What do the other regions do? Dunno. I think that is the teaching point here.

GWAS great for illuminating possible pathology, which then in turn must be dissected and validated.

Candidate screens are good for risk markers IFF there is some hint of WTF the proteins are doing for the disease.

This is why I am just flummoxed by the fact that people are still pushing tests which have little to no clinical use or even prognostic capabilities.

Listen, you want to discover yourself? Go get a cholesterol, Glycohemoglobin, and complete blood count. Check your blood pressure, check your BMI. If any of these are abnormal, go seek professional help.

But please, please, please don't use SNPs that have no science behind them as true science or clinical markers. research them, sure. But using them like MDVIP has........Risky guys.

Which reminds me. I am taking care of a patient who recently left MDVIP.......the patient had the Navigenics SNP scan done.........what do I find on family history?

The patient met Bethesda Criteria for HNPCC.........

Guess someone was too busy scanning Unproven SNPs.

That being said, this current study by Clarke suggests a few things

1. Two LPA SNPs explain approximately 36% of the overall variance in plasma Lp(a) lipoprotein levels. That could be like the CRP story. Yeah CRP levels but no association with risk. Big Whoop, but....

2. Both SNPs (one coding for the amino acid substitution I4399M and the other non coding) are associated with coronary disease. Ahem, like to see some replication here......But it could be true.

3. After adjustment for the plasma Lp(a) lipoprotein level, the association between LPA genotypes and coronary disease was abolished. Well.....that means to me, phenotypic testing with Lp(a) levels may be more useful than I had thought.....And definitely more useful than genotype testing.

The Sherpa Says: Hmmmm, maybe we will see much more of this trend. Non-genetic molecular testing being more valuable than genetic testing for risk prediction.....Wait a sec'

Video tour of Spaceport America

KRQE-TV of Albuquerque published this week a three-minute video tour of Spaceport America from a recent tour of the spaceport, part of a new bus tour program being offered to allow the public to see the spaceport under construction. The video includes a number of aerial shots that shows the current progress on the spaceport’s long runway as construction crews lay down layers of concrete and asphalt.

Thread forming taps

I have to tap about (60) holes in aluminum 6061 for 4-40 machine screws. I'm trying a thread forming tap for the first time, hoping it will go faster than with thread cutting taps and with less chance of breakage. Can you tell me what procedures to follow, as to lubricant, power vs hand tapping?

Geeky Pics: Geeky Christmas Trees

From [Geeks Are Sexy] Technology News:

Even if you don't celebrate Christmas, it's kind of hard to avoid the decorations. Of course, after seeing your millionth tree-topping star, strand of silver garland, and candy cane reindeer ornament, the trimmed trees all start to look the s

Joy to the World | Cosmic Variance

Atheists can be such uptight downers. And I say that completely seriously and non-sarcastically, despite being a card-carrying atheist myself.

The latest example appears at the Illinois State Capitol, where someone from Freedom From Religion Foundation had the genius idea of erecting this sign among the holiday displays (via PZ):

At the time of the winter solstice, let reason prevail. There are no gods, no devils, no angels, no heaven or hell. There is only our natural world. Religion is just myth and superstition that hardens hearts and enslaves minds.

Well now, there’s an uplifting and positive message. I’m sure that lots of religious folks came along to read that sign, and immediately thought “Gee, whoever wrote that sounds so much smarter and more correct than me! I will throw off my superstitious shackles and join them in the celebration of reason.”

There is a place to argue for one’s worldview — but not every single place. I happen to agree with all of the sentences on the sign above, but the decision to put in front and center in a holiday display merits a giant face-palm. (So does calling it “hate speech,” of course.) It’s like you’re introduced to someone at a party, and they immediately say “Wow, you’re ugly. And your clothes look like they were stolen off a homeless person. And you’re drinking a domestic beer, which shows a complete lack of sophistication.” I don’t know about you, but I’d be thinking — “Such taste and discernment! Here’s someone I need to get to know better.”

Until atheists learn that they don’t need to take every possible opportunity to proclaim their own rationality in the face of everyone else’s stupidity, they will have a reputation as tiresome bores. They could have put up a sign that just gave some sort of joyful, positive message. Or something light-hearted and amusing. Or they could have just left the display alone entirely, and restrained the urge to argue in favor of waiting for some more appropriate venue. (Maybe they could start a blog or something.)

Understanding how the real world works is an important skill. So is understanding human beings.


The Top 10 Science Stories of 2009

From Scientific American:

The H1N1 pandemic, the Copenhagen climate talks, the restart of the world's biggest experimental device--2009 sped by many scientifically relevant mile markers. The year also celebrated several important past events: It saw the bicentennial of Charles Dar

Christmas Laser Beam Cats

From Neatorama:

The guys who brought you An Engineer's Guide to Cats are having a friendly battle with Christmas laser beams. Things turn ugly when the nuclear hairball is deployed!

Read the whole article

Siemens Awes Autobahn Drivers With Spinning LED Christmas Star [LEDs]

With 9,000 LEDs, a little superglue and some holiday magic, Siemens and artist Michael Pendry teamed up to turn a wind turbine outside Munich into "the world's biggest revolving Christmas star." It uses as much energy as a hairdryer.

The Siemens SuperStar, which will stay spinning outside Munich through January 6th, was conceived as a project to celebrate sustainable energy and green innovation.

The SuperStar's 9000 OSRAM LEDs emit the equivalent of 22,000 candles, shining in a variety of colors and an array of spectacular patterns. Long exposure photography was used to capture the SuperStar as a vibrant spinning disk as seen above, not altogether unlike the one recently created by aliens over Norway. The video below details the process of constructing the SuperStar and shows some shots of the wheel in action.

Munich's Mayor, Christian Ude, has been an enthusiastic proponent of the energy-efficient spectacle from the start and hopes his city will be the first of its size to meet all energy requirements from renewable sources. [Siemens via Inhabitat]



Chimney Heat Exchanger

Ok everyone has seen the thing you put in your chimney to get a LOT more heat from a wood stove called the Magic Heat and looks like this,

But in the early 80's I was able to find a unit that is similar in operation, but instead of a fan in the back it used an actual blower, and the output

Call to astronomers to report Unidentified Aerial Phenomona | Bad Astronomy

denver_ufoI have been saying for years that a) most UFOs are simply misidentified mundane phenomena (satellites, meteors, balloons, Venus, weird clouds, even the Moon) and that 2) if they were real, astronomers — who spend a lot more time looking at the sky than your average person — should be reporting most of them.

My musings on this have been twisted and distorted by UFO folks — shocker! — even though I’ve been pretty clear about what I would count as evidence. But now we may have a way to cut through the garbage. A new website has been started for professional and amateur astronomers to report Unidentified Aerial Phenomena. I rather like this new UAP acronym, since it avoids the UFO/flying saucer baggage. Anyway, it was set up as part of IYA 2009 to help astronomers report things in the sky they may not immediately understand. Better yet, it has links to handy guides that will help people who might otherwise misidentify normal things like sundogs and other weather phenomena.

The website is the brainchild of Philippe Ailleris:

Despite the controversy surrounding the topic, he believes that it is possible to approach the UAP field from a professional, rational, and scientific angle without any a priori. He considers that UAP studies my increase the scientific understanding of today poorly understood natural phenomenon, and ultimately he even sees the potential for Science to discover new unknown phenomena, therefore making such study invaluable. His research therefore focuses on attempting to raise the interest of the scientific community and to bridge various fields to devise what he believes is the necessary multidisciplinary approach to studying the phenomena.

I agree. As Carl Sagan said, whether UFOs are real and we’re being visited, or they’re a mass social phenomenon due to the way our brains work, either aspect is fascinating and worthy of actual study.


The Secret Lives of Amazon’s Elves [Holiday Shopping]

If Amazon is Santa, 400 folks living in RVs outside the Coffeyville, Kansas fulfillment center this winter are the elves.

A few years back Chris Dunphy and Cherie Ve Ard flipped the bird to their desk jobs, packed their belongings in a custom 17-foot solar-powered fiberglass camper, and hit the road to live "at the intersection of Epic and Awesome." A couple months ago, while staying with friends, they noticed that Amazon was luring RVers to Coffeyville, Kansas, the site of the retail giant's original and largest fulfillment center.

"We were located in San Diego at the time," explained Cherie. "We're part of a community of younger full-time RVers on Nurvers.com, a group of non-retired-age folks who are living the mobile lifestyle and kind of going outside the norms of 'Wait for retirement to travel.'" They noticed other RVers were flocking to Kansas to work for Amazon. The pay wasn't great—just above $10-an-hour, typically—but Chris and Cherie were planning on being in St. Louis for the holidays. Why not kill a month in Kansas working for Amazon?

Fast forward a couple of weeks, and the self-styled "technomads" were putting down stakes at a state park about 20 miles from the four enormous but dull warehouses that comprise the Coffeyville hub.

Their first day inside, Chris was awed. "Walking inside reminded me of the scene from Indiana Jones when they abandon the Ark in that giant warehouse. It's three stories high. It feels like an industrial library. Shelves going up and up and up." Hundreds of employees scurried, some "orange-badges" or "green-badges" hired by two temporary employment services mixed with the sought-after blue-badges of full-time Amazon employees, guided to their next destination by computers that flashed lights when bins were full or guided workers through the maze with handheld computers. "Pickers are basically playing a human Pac-Man game. They've got a computer scanner that they carry around that tells them where to go. They find their little shelf. One slot might be a book. The next shelf over might be a toaster. Or an iPod. The next slot after that might be a pair of jeans."

Fiberglass City

Amazon didn't always lure in "workcampers" from the RV community.

"From what the agency people had told us, Amazon had a bad experience busing in people from Tulsa," says Chris. "There was a lot of theft and a lot of people who weren't really serious about the job."

Workers from Tulsa were adding a 4-hour round-trip commute to an already grueling 10-to-12 hour shift, Cherie is quick to add. "They'd get there exhausted."

Enter the workcampers, people making a go at living in their RVs full time—many of whom might be otherwise overqualified. "I think Amazon was skeptical at first," says Cherie. "But after the first trial year they were very, very impressed. Workcampers came in enthusiastic about working, since most are professionals. We've owned businesses or been managers." White collar workers, trying their hand at the gypsy life. Even better, the workcampers were able to stay locally.

Not all of the camps provided for the workcampers were exactly inviting.

Chris and Cherie pulled into the one just before Thanksgiving, but could tell it wouldn't make for a pleasant stay. "The closest one was a city park called Walter Johnson. RVs were very close together. Half the campsites had full hookups, which meant they had water, electricity, and sewer dump on-site. Half the sites just had electricity and water and they had what they call a 'Honey Wagon' that comes around and pumps your sewage out a few times a week." Some RVers had been in Coffeyville since August.

Worse, it was cramped and muddy. "Coffeyville also had a flood three years ago, so it was very, very wet and muddy because the area had been washed out, then rained on recently." They eventually moved on to a state park, which was lovely, but also four times farther away. They rarely had time to enjoy the scenery.

"We were on the night shift," says Chris, "Our day would start when we would wake up at three in the afternoon. Work started at five."

"Every shift starts with what they call a 'Stand Up.' You gather in one area with your usual department—ours was called 'Sortable Singles,' which sounds like it should be the name of a dating site—and they'd count off how many people they needed in each department. Run through a few announcements. Give you a few safety tips. And then they lead you through five minutes of group stretches."

Cherie was mainly a packer, putting items in the box and scanning them. Chris, on the other hand, was a "water spider." He explains, "A water spider is responsible for keeping all the packers supplied, so ideally they'd never need to stand up and leave their station to get any other supplies like all the different sizes of boxes, plus making sure their tape machines and paper-spitter machines are operating."

"I never quite exactly figured out why they call it a water spider. My guess is back in the history of assembly line jobs, the water spider would be the person who would bring people on the line water to drink. Nobody seemed to know!"

The Mocha Factory

Work was monotonous and—for a couple who had been living a relative life of leisure—full of endless hours of standing on one's feet.

"24-Hour Fitness, Amazon-style," laughs Chris. Cherie liked to think of it as having "a personal trainer for 60 hours a week."

Inside the warehouses, machines and man alike were controlled by Amazon's computerized assembly line.

In one part of the factory, Chris watched two giant elliptical carousels, each one the size of a football field, carry wooden trays around at 15mph. "All the items are coming in the totes on one side of this giant machine. There are people who take each individual item, scan them and put them on the trays as they go by. The trays get to a chute where their order is being assembled, tilt, and the product flies down into that space. When all the items for a particular order are assembled in one place an orange light comes on and somebody comes by." Above, another carousel brought an endless procession of empty boxes to be filled with the orders.

It wasn't exactly what Cherie had envisioned. "When we told people were going to do this, someone said 'Whenever I click the order button on Amazon, I always imagine a chorus of happy, singing Oompa-Loompas riding around on Segways and shipping my stuff.' Well...no. It's not exactly like that."

"The computer has to prioritize how it's going to send out all the pickers in this giant facility. So someone could order a book and a sweater and an iPod, and those could be in completely different corners of the whole facility. But somehow they all arrive within about 30 minutes of each other." It's efficiency even Willy Wonka could love.

Chris and Cherie wouldn't work another season at Coffeyville, but not because they were miserable. "Everybody treated each other really nicely!" says Chris. It's just that the two are "experience junkies, craving the new," even if working for Amazon certainly gave them a fresh perspective on American culture.

"You'd have a tote come down the line, and you'd have adult toys right next to kid toys in the same bin," laughs Cherie. "The Obama Chia Pet was an oddity. And the Bill Clinton corkscrew. And I did have a tote one afternoon that was full of mooning gnomes."

Chris geeked on it pretty hard. (Before he became an migrant worker, Chris was a founding editor for boot magazine—later known as Maximum PC. He also worked for Palm.) "Just getting to experience that type of work, to literally see consumer culture flow beneath your fingertips, was absolutely fascinating. You feel the pulse of the market."

Besides their paychecks, all they're left with are memories—cameras weren't allowed inside.

"One of the rules at Amazon is that you're not allowed to bring anything into the facility that they sell." Chris went through a bit of withdrawal. "One of the hardest things about the job was going without my iPhone for a month. It was a great way to break the addiction of wanting to Twitter about things. You'd be like, 'Oh my God, I just saw this Bill Clinton corkscrew and you won't believe where the corkscrew comes out.' But oh crap, I can't tweet."



Libertarian Policy Expert Peter Ferrara says there’s a Huge Difference between Major Parties

Libertarians and others who see no difference - "gullible boobs"

From Eric Dondero:

Many Libertarians, particularly those in the Libertarian Party, like to say there's "no difference between the Democrats and Republicans." Tweedle-dee and Tweedle-dum is their common refrain.

Now, top libertarian policy analyst Peter Ferrara is taking fellow libertarians and others on the Right to task for being sucked into Obama's seeming "post-partisanship." Ferrara points out that with a straight party-line vote on Health Care, and near Party-line vote on Cap & Trade, the old Tweedle-dee, Tweedle-dum line has become obsolete.

Ferrara argues that Obama has proven to be the ultimate Uber-Leftist extremist Partisan.

Excerpt from "Too Many Democrats in Washington" at AS Political Hay.

From the American Spectator Dec. 23:

The Senate's votes this week on the pending government takeover of health care are highly instructive. With all 60 Democrats voting yes, and all 40 Republicans voting no, the simplistic homily that there is no difference between the parties has now proven to be a very costly fallacy...

the House passed the President's cap and trade tax bill on a virtual party line vote. Then the House did the same with its health bill. Now we have the completely partisan Senate vote as well...

This has been a persistent pattern all year. When campaigning for office in 2008, candidate Obama promised the American people a new era of post-partisanship, where he would bring Democrats and Republicans together to solve the nation's problems. There was nothing in Obama's ultraliberal background to suggest he would be remotely capable of this. Sure enough, since his election, this promise of post-partisanship has proven to be boob bait for the gullible.

He goes on to call so-called moderate Democrat Senators Ben Nelson, Jim Webb, Mark Warner, Blanche Lincoln and Evan Bayh, "phonies," who have "duped the voters of their state."

Ferrara continues, that in contrast to the Republicans:

Democrats are the party of Big Government bureaucracy and runaway government spending.

Peter Ferrara is a libertarian public policy analyst based in DC. He has worked for the Cato Institute, and other economic libertarian groups such as Americans for Tax Reform. In 2005 he received national acclaim, along with vicious criticism from the Left, for having authored the outline for President Bush's Social Security privatization plan.

The USB Hourglass [USB]

An optical sensor checks this mini hourglass eventually triggering the rotating mechanism to flip the thing 180 degrees. It also can send the optical sensor's values to a PC by USB, providing random numbers. I just think it looks cool.

There are some good non-deterministic random sources disclosed on the Internet. They make use of radioactive decay, radios tuned to secret frequencies where there is no broadcast, dice rolling down a chute, and even lava lamps.

The USB Hourglass compares well with these sources in terms of bit-rate, cost, safety, reliability, and simplicity.

[USB Hourglass via boingboing]



How Secure is the Cloud?

Google has been accused of hypocrisy in its negotiations with the city of Los Angeles. Google hopes to convince the city to move from its desktop-based e-mail and office applications to Google's hosted ("cloud-based") offerings. A consumer advocacy group says the company publicly talks up the securi

Is Recycling Waste Paper a Waste of Time?

Even if consumers are careful to separate paper products and put them in the proper recycle bins, it ends up getting mixed up with other refuse in the trucks, reports Ellen Moorhouse in the Toronto Star. Paper makers who use post-consumer material are finding they are spending millions of dollars to