Dutchman had coronavirus for 613 days; Virus mutated over 50 times in his body – NL Times

A Dutch man was infected with the coronavirus for 613 days, researchers from the Amsterdam UMC report. To the authors' knowledge, it is the longest SARS-CoV-2 infection duration to date. The virus muted over 50 times in his body.

The 72-year-old immunocompromised man continuously tested positive for SARS-CoV-2 from his admission to an Amsterdam clinic in February 2022 until he died of an underlying condition in October 2023. He initially became infected with the Omnicron variant of the coronavirus, but the virus mutated over 50 times in his body. As far as the researchers know, he did not infect anyone else with his mutated form of the virus.

Such persistent coronavirus infections are rare, but several cases of infections lasting hundreds of days in immunocompromised patients have been reported. Researchers worry that these persistent infections could lead to more mutations in the coronavirus. For instance, it is thought that the initial emergence of the Omicron variant originated in an immunocompromised individual, highlighting the importance of close genomic surveillance in this patient population. Not all mutations may be as manageable as the Omicron variant.

We emphasize the importance of continuing genomic surveillance of SARS-CoV-2 evolution in immunocompromised individuals with persistent infections given the potential public health threat of possibly introducing viral escape variants into the community, the researchers said. They stressed that there must be a balance between this surveillance and human supportive care for the patients involved.

The researchers also stressed that from the viewpoint of the general public, prolonged infections remain rare as the immunocompromised population is only a very small percentage of the total population.

The Amsterdam researchers will present their findings at the ESCMID medical congress in Barcelona between April 27 and 31.

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Dutchman had coronavirus for 613 days; Virus mutated over 50 times in his body - NL Times

Victim’s brother arrested in connection with deadly shooting – WCVB Boston

State and federal law enforcement in Maine on Tuesday announced the arrest of a Massachusetts man who was wanted in connection with the shooting that killed his brother in Brockton on Easter morning. Jeremiah Abreu, 20, of Brockton, was arrested at 2:30 p.m. after leaving a home in Lewiston, Maine, according to the office of Plymouth District Attorney Tim Cruz. The arrest warrant for a charge of murder was executed by members of the U.S. Marshals Service and Maine State Police.The Lewiston Police Department said Abreu was taken into custody following a coordinated traffic stop. Abreu was transported to the Androscoggin County Jail, where he will await extradition.Abreu's brother, Sedrick Abreu, 27, was found with a gunshot wound to the chest inside a home at 36 Hoover Ave. in Brockton at 2:17 a.m. on Sunday. He was taken to Good Samaritan Medical Center, where he was pronounced dead of his injuries.Two other suspects, Sirick Amado, 24, and Antonio Dejesus, 26, were already arrested and charged with accessory to homicide. Amado and Dejesus were arraigned Monday in Brockton District Court.During the arraignment, prosecutors said surveillance video shows Amado give a gun to Jeremiah Abreu before Abreu went inside the Hoover Avenue home."At that time is when officers believe that Mr. Abreu shot and killed his brother," Assistant District Attorney Kristina Zanini said in court.Prosecutors also said surveillance video shows Abreu exit the home and give the gun to Dejesus, who then placed an item in the back of an SUV. Attorneys representing Amado and Dejesus said the surveillance video does not definitively show what happened, and that investigators did not find a gun when they searched the SUV.Amado and Dejesus are being held without bail until a dangerousness hearing, which is scheduled for Thursday.Lewiston police also said they arrested 22-year-old Dominic Peterson, also of Brockton, Massachusetts, during the coordinated traffic stop.According to Lewiston police, Peterson was in the vehicle that Jeremiah Abreu was traveling in Tuesday and he refused to identify himself.Police said Peterson was found to be in possession of a firearm and was taken to the Lewiston Police Station, where he was identified with the use of fingerprint analysis.Lewiston police said Peterson was wanted on numerous warrants out of Massachusetts, including assault and battery of a family members, assault with a dangerous weapon, possession of ammunition without an FID card, carrying a firearm without a license and carrying a loaded firearm without a license.Peterson was also charged with failure to provide corrected name/address/DOB, illegal possession of a firearm and fugitive from justice by Lewiston police

State and federal law enforcement in Maine on Tuesday announced the arrest of a Massachusetts man who was wanted in connection with the shooting that killed his brother in Brockton on Easter morning.

Jeremiah Abreu, 20, of Brockton, was arrested at 2:30 p.m. after leaving a home in Lewiston, Maine, according to the office of Plymouth District Attorney Tim Cruz. The arrest warrant for a charge of murder was executed by members of the U.S. Marshals Service and Maine State Police.

The Lewiston Police Department said Abreu was taken into custody following a coordinated traffic stop. Abreu was transported to the Androscoggin County Jail, where he will await extradition.

Abreu's brother, Sedrick Abreu, 27, was found with a gunshot wound to the chest inside a home at 36 Hoover Ave. in Brockton at 2:17 a.m. on Sunday. He was taken to Good Samaritan Medical Center, where he was pronounced dead of his injuries.

Two other suspects, Sirick Amado, 24, and Antonio Dejesus, 26, were already arrested and charged with accessory to homicide.

Amado and Dejesus were arraigned Monday in Brockton District Court.

During the arraignment, prosecutors said surveillance video shows Amado give a gun to Jeremiah Abreu before Abreu went inside the Hoover Avenue home.

"At that time is when officers believe that Mr. Abreu shot and killed his brother," Assistant District Attorney Kristina Zanini said in court.

Lewiston Police Dept.

Prosecutors also said surveillance video shows Abreu exit the home and give the gun to Dejesus, who then placed an item in the back of an SUV.

Attorneys representing Amado and Dejesus said the surveillance video does not definitively show what happened, and that investigators did not find a gun when they searched the SUV.

Amado and Dejesus are being held without bail until a dangerousness hearing, which is scheduled for Thursday.

Lewiston police also said they arrested 22-year-old Dominic Peterson, also of Brockton, Massachusetts, during the coordinated traffic stop.

According to Lewiston police, Peterson was in the vehicle that Jeremiah Abreu was traveling in Tuesday and he refused to identify himself.

Police said Peterson was found to be in possession of a firearm and was taken to the Lewiston Police Station, where he was identified with the use of fingerprint analysis.

Lewiston Police Dept.

Lewiston police said Peterson was wanted on numerous warrants out of Massachusetts, including assault and battery of a family members, assault with a dangerous weapon, possession of ammunition without an FID card, carrying a firearm without a license and carrying a loaded firearm without a license.

Peterson was also charged with failure to provide corrected name/address/DOB, illegal possession of a firearm and fugitive from justice by Lewiston police

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Victim's brother arrested in connection with deadly shooting - WCVB Boston

COVID and flu cases are rising across the U.S. : Shots – Health News – NPR

COVID cases are rising but hospitalizations and deaths are lower than last year's respiratory virus season. Patrick Sison/AP hide caption

COVID cases are rising but hospitalizations and deaths are lower than last year's respiratory virus season.

In most U.S. states, respiratory illness levels are currently "high" or "very high," according to data from the Centers for Disease Control and Prevention released Friday.

"After the holidays, after we've traveled and gathered, we are seeing what is pretty typical of this time of year, which is a lot of respiratory viruses," says Dr. Mandy Cohen, director of the CDC.

A few viruses have been driving the upward trend, including flu which is very high and respiratory syncytial virus or RSV which appears to have peaked around Thanksgiving.

COVID-19 levels have climbed higher than last season's peak. Still, they remain far below where they were at the height of the pandemic as do levels of severe disease.

"We are still very far below the levels that we were seeing with the omicron peak [in the 2021-2022 virus season]," says Amy Kirby, who leads the CDC's National Wastewater Surveillance System. "We're not looking at that really massive wave of infections. This is much more on par with what we saw [in the 2022-2023 season]."

And while COVID levels are still higher than they were last season, other COVID metrics including emergency room visits, hospitalization rates and deaths are lower now than previous seasons, indicating that "COVID-19 infections are causing severe disease less frequently than earlier in the pandemic," according to the CDC.

Respiratory viruses are hitting the southeast especially hard, said the CDC's Cohen, "but no part of the country is spared."

Flu levels are especially concerning. "The influenza virus is the thing that's really skyrocketing right now," says Dr. Steven Stack, public health commissioner for the state of Kentucky and president of the Association of State and Territorial Health Officials. "Influenza is sharply escalating and driving more hospitalizations."

The flu is coming in later this season, compared with the 2022-2023 season, when "RSV and flu really took off right at the same time along with COVID," says Marlene Wolfe, assistant professor of environmental health at Emory University and a program director at WastewaterScan. "All three of those together were pretty nasty. This year, there's more of an offset."

That has been good news so far for hospital capacity, which has remained stable this season, meaning that people who are quite ill and need medical care are generally able to get it.

Some hospitals in different parts of the country from Massachusetts to Illinois to California are starting to require masks for staff again and in some cases for patients and visitors.

Health officials say that getting the latest flu and COVID-19 vaccines now can still protect people this season. While Stack, with Kentucky's Department for Public Health, encourages seasonal preventive shots for everyone 6 months and older, he says it's particularly important for "everybody who is elderly and not even old elderly like young elderly, 60 and older," since they are more likely to get very sick from these viruses.

CDC data shows that fewer than half of U.S. adults have gotten a flu shot this fall and winter. That's still better than the vaccination rate for this season's COVID-19 booster, which fewer than 20% of U.S. adults have gotten, even though COVID-19 remains the bigger danger.

"The thing that is putting folks into the hospital and unfortunately taking their lives the virus that is still the most severe [at the moment] is the COVID virus," says the CDC's Cohen.

Beyond vaccines, health officials say there's still a place for masking as a preventive measure.

Those who are sick should stay home and watch their symptoms. If they progress beyond a runny nose and a light cough "to body aches, fevers, difficulty moving through your day, a heavier runny nose, a worsening cough ... [those more severe symptoms] should trigger you to go get tested," says Cohen.

Getting tested and diagnosed early, with COVID-19 or the flu, can help those at risk of serious illness get access to prescription pills that can reduce their chances of ending up in the hospital.

Flu and COVID-19 vaccines, tests and treatments should be covered by health insurance.

For those who are uninsured, the government is also offering a program called Test to Treat that offers free tests, free telehealth appointments and free treatments at home.

Cohen says people can protect themselves over the next few weeks by staying aware of what's happening in the community and their individual circumstances.

"You want to know what's happening in your community," she says. "Is there a lot of virus circulating? And then, what are the tools that I could layer on to protect myself, depending on who I am, my age, my risk, as well as who I'm around?"

The CDC has maps of COVID-19 hospitalizations down to the county level on its website, and it provides weekly updates on respiratory viruses nationwide. Cohen says there are many tools including vaccines, masks, rapid tests and treatments available to help people reduce their risks this season.

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COVID and flu cases are rising across the U.S. : Shots - Health News - NPR