DNA Synthesis Market to hit USD 20.5 Bn by 2032, says Global Market Insights Inc. – GlobeNewswire

Selbyville, Delaware, April 22, 2024 (GLOBE NEWSWIRE) -- DNA Synthesis Market size is expected to reach a remuneration of USD 20.5 billion by 2032. Rising advancements in biotechnology and genetic engineering across various research, diagnostic, and therapeutic applications will augment the industry growth.

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With the rise of precision medicine and personalized healthcare, there is a growing need for custom-designed DNA sequences tailored to specific research objectives or patient requirements. For instance, in March 2024, global genomics solutions provider Integrated DNA Technologies (IDT) expanded its gene synthesis offerings by introducing a new custom vector onboarding tool. The advancing fields of synthetic biology and gene editing techniques, such as CRISPR-Cas9 have further propelled the demand for DNA synthesis, as researchers seek to engineer novel organisms and develop innovative therapies for various diseases.

Collaborations between academic institutions, biotechnology companies, and pharmaceutical firms are also facilitating the development of cutting-edge technologies and streamlined workflows in DNA synthesis. These partnerships foster innovation and knowledge exchange, driving advancements in the methodologies while expanding the repertoire of available synthetic DNA products. Furthermore, the increasing affordability and accessibility of DNA synthesis services, coupled with improvements in synthesis throughput and scalability are democratizing access to synthesized DNA for researchers worldwide.

Rising usage for diagnostics

DNA synthesis market share from the therapeutic application segment is slated to gain momentum through 2024-2032. This is driven by the increasing adoption of molecular diagnostics for disease detection and personalized treatment approaches. Custom-designed DNA sequences help in the development of molecular diagnostic tests, enabling precise detection of genetic mutations and biomarkers associated with various diseases. The advent of targeted therapies and gene editing technologies has also fueled the demand for synthesized DNA in therapeutic applications.

CRO segment to gain traction

The DNA synthesis market from the contract research organization (CRO) segment is expected to expand exponentially up to 2032. This is driven by specialized expertise and infrastructure for DNA synthesis services for catering to the diverse needs of pharmaceutical, biotechnology, and academic research institutions. These organizations possess state-of-the-art facilities equipped with high-throughput synthesis platforms and experienced scientific teams capable of delivering custom-designed DNA sequences with precision and efficiency. CROs also provide end-to-end solutions, including gene synthesis, cloning, and sequence verification, allowing clients to focus on their core research objectives while entrusting the synthesis process to specialized professionals.

Asia Pacific to emerge as a prominent industry

Asia Pacific DNA synthesis market is estimated to record significant valuation by 2032, attributed to the increasing investment in genomics research and biotechnology initiatives by governments and private enterprises across countries like China, Japan, and India. The rising prevalence of genetic disorders and infectious diseases in the region has spurred the demand for customized DNA sequences for diagnostic and therapeutic applications. Advancements in healthcare infrastructure and the growing adoption of precision medicine will further stimulate the regional industry growth.

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DNA Synthesis Industry Players

Some of the prominent DNA synthesis market players include Thermo Fisher Scientific, Inc., ELISA experts, Twist Bioscience, BOSTER antibody, Bioneer Corporation, ProteoGenix, Eton Bioscience, BIOMATIK, LGC Biosearch Technologies, ProMab Biotechnologies, IBA GmbH, Eurogentec, Eurofins Scientific, Quintara Biosciences OriGene Technologies, Inc., Integrated DNA Technologies, Inc.and GenScript Biotech Corporation.

These firms are focusing on partnership ventures and innovations to proliferate their product portfolio and customer base. To cite an instance, in August 2023, Genscript Biotech formed a strategic collaboration agreement with T-MAXIMUM Biotech to develop CAR-T cell therapy.

Partial Table of Contents (ToC) of the report:

Chapter 2Executive Summary

2.1 Global DNA synthesis market 360 synopsis, 2018 2032 2.1.1 Business trends 2.1.2 Regional trends 2.1.3 Service trends 2.1.4 Method trends 2.1.5 Application trends 2.1.6 End-use trends Chapter 3DNA Synthesis Industry Insights 3.1 Industry ecosystem analysis 3.2 Industry impact forces 3.2.1 Growth drivers 3.2.1.1Growing prevalence of diseases globally 3.2.1.2Rapid technology advancements in the field of synthetic biology 3.2.1.3Rising investments towards research and development(R&D) activities 3.2.2 Industry pitfalls & challenges 3.2.2.1Stringent government regulations and guidelines 3.2.2.2High cost, potential biosafety,biosecurity and ethical issues 3.3 Growth potential analysis 3.3.1 By service 3.3.2 By method 3.3.3 By application 3.3.4 By end use 3.4 COVID- 19 impact analysis 3.5 Regulatory landscape 3.5.1 U.S. 3.5.2 Europe 3.6 Porter's analysis 3.7 PESTEL analysis

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About Global Market Insights

Global Market Insights Inc., headquartered in Delaware, U.S., is a global market research and consulting service provider, offering syndicated and custom research reports along with growth consulting services. Our business intelligence and industry research reports offer clients with penetrative insights and actionable market data specially designed and presented to aid strategic decision making. These exhaustive reports are designed via a proprietary research methodology and are available for key industries such as chemicals, advanced materials, technology, renewable energy, and biotechnology.

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DNA Synthesis Market to hit USD 20.5 Bn by 2032, says Global Market Insights Inc. - GlobeNewswire

Air Macau welcomes first of two wide-body aircrafts under plan to expand international network – Inside Asian Gaming

Air Macau has announced that the first wide-body aircraft to bne introduced to its fleet this year has arrived in Macau.

The A330-300 landed in Macau from Hangzhou on Sunday morning and flew to Beijing that afternoon, having been leased from Air China.

Air Macau said it plans to introduce a second wide-body aircraft in the second half of this year to operate medium- and long-haul routes, and to add Middle East destinations as part of efforts to expand its European network.

The company first revealed in January that it would introduce two wide-body aircraft this year to complement the development of Macaus aviation industry.

Air Macau introduced its first wide-body aircraft, the A300-600R wide-body aircraft, in 2006 after which time it launched the Taipei-Macau-Shanghai route. However, in 2007 the aircraft was converted into a freighter.

There are currently 26 airlines operating out of Macau International Airport, with routes covering 23 destinations in mainland China, three destinations in Taiwan and 17 international destinations. The passenger market distribution is 46% from mainland China, 16% from Taiwan and 38% from international markets.

Macau International Airport Corporation Limited (CAM) said recently that it would invest more resources into creating incentives for airlines to operate international and medium- and long-haul direct routes.

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Air Macau welcomes first of two wide-body aircrafts under plan to expand international network - Inside Asian Gaming

Pioneering Emotional Intelligence in Robotics: The Rise of Emo – yTech

In a breakthrough for robotics and artificial intelligence (AI), a robot named Emo stands as a testament to technological ingenuity, possessing the capability to learn and replicate human emotional expressions. This development marks a significant stride in narrowing the emotional divide between humans and machines, potentially reshaping the way we interact with robots in a multitude of sectors.

Core Innovation Behind Emos Emotional Acuity Emos core innovation lies in its dual neural network architecture, which empowers the robot with unprecedented emotional intelligence. By utilizing advanced cameras and motor systems, Emo can observe and assimilate human expressions. Over time, its capacity to respond in contextually relevant ways improves, making human-robot interactions increasingly natural and seamless.

Professor Hod Lipson and his team are the visionaries behind Emos conceptualization and realization. Their work paves the way for a future where robots can forge emotional bonds with humans, setting a new benchmark in social robotics.

Potential for Transformative Impact Across Industries The ripple effect of Emos introduction is vast, with implications for customer service, therapy, elder care, and education. It foretells significant growth within the social robotics market, with affordable manufacturing techniques on the horizon and analysts predicting robust market development bolstered by the integration of empathetic robots in everyday life.

Navigating the Ethical Considerations of Advanced Robotics Notwithstanding the advancements and promises of Emos technology, ethical questions loom. Issues surrounding emotional authenticity, privacy, and employment disruptions accentuate the need for conscientious deployment of such robots. This underscores the importance of engaging with ethics-focused organizations like IEEE and ACM, which strive to establish standards that balance technological progress with societal well-being.

In summary, Emo represents a fusion of AI and emotional perception, potentially revolutionizing human-robot interaction and industry practices. Its advent warrants thoughtful consideration of the ethical landscape as we embrace the age of emotionally intelligent machines. The robotic companions evolution and the industrys path forward will be characterized by ethical vigilance, research brilliance, and insightful analysis, jointly shaping the role of robotics in our future.

Expanding the Market Forecast for Emotionally Intelligent Robots The global market for social and emotional robotics is expected to experience substantial growth over the coming years. According to a report by MarketsandMarkets, the social robot market, in particular, is expected to rise from USD 918 million in the current scenarios to over USD 3,900 million by the next decade, expanding at a CAGR of 14.5% during the forecast period. This growth is fueled by increasing adoption in sectors such as personal assistance, education, and healthcare, where they can perform tasks ranging from companionship to assisting with cognitive therapy and rehabilitation.

The emergence of robots like Emo will spur further research and development, reducing costs and enhancing functionalities. This will likely attract investment and increase the accessibility of these robots, thus making them more commonplace in both consumer and commercial environments.

Challenges and Controversies Within the Robotics Industry Despite these promising market forecasts, the robotics industry faces challenges and controversies that could impact the emotional intelligence sector. One of the primary concerns is job displacement, as robots become capable of performing tasks typically reserved for human workers. This could lead to significant shifts in the labor market and necessitate retraining for those whose jobs are affected.

Another key consideration is data privacy and security, especially with robots that can collect and analyze personal emotional data. Ensuring that this information is used responsibly and securely is paramount to maintaining public trust.

For research, development, and the establishment of standards in robotics, resources can be found through organizations such as IEEE and ACM.

Summary and Industry Outlook In conclusion, Emo exemplifies the potential for emotion recognition in robotics to drive innovation across various sectors. The social and emotional robot industry is anticipated to flourish, bringing about advancements in how these machines are integrated into our daily lives. As the industry progresses, it will be essential to monitor market dynamics, foster ethical practices, and encourage responsible innovation, thereby ensuring that the evolution of robots like Emo contributes positively to society.

The success of products like Emo and the industrys trajectory will heavily rely on striking a balance between innovation and the humane and ethical application of technology. Thought leaders, developers, and policymakers will need to collaborate to navigate these challenges successfully. The trends in the robotics industry point towards a future where emotionally intelligent machines become an integral part of the fabric of society, enhancing human life while addressing the ethical implications of such profound technological integration.

Leokadia Gogulska is an emerging figure in the field of environmental technology, known for her groundbreaking work in developing sustainable urban infrastructure solutions. Her research focuses on integrating green technologies in urban planning, aiming to reduce environmental impact while enhancing livability in cities. Gogulskas innovative approaches to renewable energy usage, waste management, and eco-friendly transportation systems have garnered attention for their practicality and effectiveness. Her contributions are increasingly influential in shaping policies and practices towards more sustainable and resilient urban environments.

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Pioneering Emotional Intelligence in Robotics: The Rise of Emo - yTech

The 3 Most Undervalued Robotics Stocks to Buy in April 2024 – InvestorPlace

AI led the stock market to unprecedented heights last year, beckoning interest in complementary technologies such as robotics. Thanks to game-changing advancements in AI and automation technology, the robotics space is evolving swiftly. Consequently, these developments effectively pave the way for investors to scout for the most undervalued robotics stocks to buy in April.

To be fair, the development of Robotic AI hasnt been at the same pace at which generative AI or branches of the technology are growing. Nevertheless, the sector has been showing remarkable progress, and AI can potentially take things up a few notches. Improvements in robot durability and functionality are a testament to what lies ahead. That said, three stocks are leading the charge in robotics, offering strong long-term upside potential.

Source: Sundry Photography / Shutterstock.com

Intuitive Surgical(NASDAQ:ISRG) is a force to be reckoned with in the fast-growing robotic-assisted surgical solutions industry. Its primary offering, the da Vinci Surgical System, facilitates minimally invasive operations with greater accuracy and agility.

Moreover, the da Vinci Surgical System has been a major needle-mover for ISRG, facilitating upwards of 13 million surgical procedures. Its incredible impact on the company can be seen in the 234% jump in sales to $7.1 billion from 2014 to last year. Also, its steady income streams have had a similar impact on its eye-catching bottom-line numbers.

ISRG has been killing it by posting strong numbers late despite operating in an unconducive market. It comfortably beat analyst estimates in three out of the four past quarters across both lines by considerable margins. In its most recent quarterly report, revenues were up to $1.93 billion, a 16.51% increase on a year-over-year (YOY) basis. Likewise, net income came in at an impressive $606.2 million, beating expectations by more than 85%. Additionally, with an aging population, expect ISRG to continue posting similar numbers for the foreseeable future.

Source: Michael Vi / Shutterstock.com

Defense solutions providerKratos(NASDAQ:KTOS) is a critical cog in the wheel, driving innovation through its robust product portfolio. It specializes in the development of modern military operations and the deployment of unmanned systems.

These products are effectively designed for surveillance, reconnaissance, and combat operations. Over the years, it has been an excellent wealth compounder, delivering more than 136% gain in the past decade. The impressive uptick in its price is linked to its spectacular growth in top-and-bottom-line results, marked by double-digit gains across key metrics. Moreover, recent results have been a visual treat for its investors, with it outperforming estimates across both lines in the past seven consecutive quarters.

Furthermore, as a recent article from my fellow InvestorPlace colleague, Larry Ramer, explains, Kratos has recently inked some massive contracts from the U.S. government. Perhaps the most noteworthy is its $579 million deal with the U.S. Space Force. Additionally, in March alone, it received contracts exceeding $550 million in value from the Pentagon.

Source: Daniel J. Macy / Shutterstock.com

ABB(OTCMKTS:ABBNY) is a top pick in the burgeoning industrial automation, leveraging AI to push the envelope in the Industrial Internet of Things (IIOT) industry. ABBNY stock got a strong AI-powered boost in the stock market last year,gaining over 34%.

According to ABB, roughly 20% of the data produced by industrial entities undergoes analysis and an even smaller fraction results in actionable insights. Hence, it is looking to pounce on this underserved market with its power Genix software, which harnesses AI for industrial analytics, aiming to unlock valuable insights for its customers.

Despite AIs disruptive impact, ABB doesnt solely rely on its software analytics business. It runs a diversified operation providing robotics, automation, electrification, and motion products globally. Moreover, given the diversity in its revenue base, it operates a highly consistent business thats been exceptionally profitable across key metrics. On top of that, it offers a growing dividend,yielding over 2.1%.

On the date of publication, Muslim Farooque did not have (either directly or indirectly) any positions in the securities mentioned in this article. The opinions expressed in this article are those of the writer, subject to the InvestorPlace.com Publishing Guidelines.

Muslim Farooque is a keen investor and an optimist at heart. A life-long gamer and tech enthusiast, he has a particular affinity for analyzing technology stocks. Muslim holds a bachelors of science degree in applied accounting from Oxford Brookes University.

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The 3 Most Undervalued Robotics Stocks to Buy in April 2024 - InvestorPlace

Meet Kimi AI, The Chinese ChatGPT – Dataconomy

Moonshot AI has introduced a Chinese ChatGPT: Kimi AI, backed by Alibaba, an advanced chatbot designed to revolutionize how we interact with technology, even if you put 2 million characters or tens of thousands to hundreds of thousands of words in the chatbox. But what exactly is Kimi, and what sets it apart in the world of AI? Lets dive in and explore the marvels of this innovative creation.

Kimi is a large language model (LLM) chatbot developed by Moonshot AI, a Beijing-based startup. Essentially, a large language model is an artificial intelligence (AI) system trained on vast amounts of text data to understand and generate human-like text responses. These models have become increasingly sophisticated, enabling them to process and generate natural language with remarkable accuracy. In Kimi AIs case, its like a smart robot that can talk to people using written words on a computer or phone screen. You can connect to the web or upload PDFs on the AI chatbot.

What makes Kimi AI special is that its really good at understanding what people say and responding in a way that makes sense. Recently, the team behind Kimi made it even smarter by teaching it to understand really long messagesup to 2 million Chinese characters in one go!

Kimi Smart Assistant is a versatile tool designed to cater to the diverse needs of various groups of people. Heres how Kimi can lend a helping hand:

Kimi makes life easier for all these people by helping them complete tasks quickly and get things done better, especially in Chinese. However, if you want to use Kimi AI, you should have a WeChat account.

Claude 3 vs ChatGPT: Are Claude 3 models better than ChatGPT?

Moonshot AI is a Beijing-based startup specializing in advanced artificial intelligence (AI) technology. Founded in April 2023, the company has quickly become a leader in AI innovation, particularly in the development of large language models (LLMs) and conversational AI solutions.

Their flagship product, Kimi AI chatbot, has gained widespread acclaim for its ability to understand and generate human-like text responses. Moonshot AIs mission is to harness AIs power to solve real-world problems and enhance human-machine interactions.

Through strategic partnerships like Alibaba and products like Kimi, we probably hear their name more soon.

Featured image credit: Eray Eliak/Bing

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Meet Kimi AI, The Chinese ChatGPT - Dataconomy

This astronaut took 5 spacewalks. Now, he’s helping make spacesuits for future ISS crews (exclusive) – Space.com

The next generation of spacesuits for astronauts just went parabolic.

Collins Aerospace tested its new spacesuit design, built for International Space Station spacewalks, on a parabolic flight that simulated microgravity conditions. The goal was to fulfill requirements for a NASA contract aimed at replacing the long-standing extravehicular mobility units (EMUs) now used on the orbiting complex.

Following the news release on Feb. 1, Collinschief test astronaut John "Danny" Olivas a retired NASA astronaut spoke with Space.com about the company's plans for the floating suit. He also discussed exciting possibilities for moon exploration. Read on to learn more about how Olivas is using his past spacewalking experience to pave the way for future spacewalkers.

Collins received a 2022 task order from NASA to develop a next-generation EMU to be lighter and more flexible than current spacesuits. These suits are also under consideration to become moonwalking outfits for the agency's Artemis program; the design team received a separate task order in July 2023 to modify the floating-style spacesuits for surface excursions.

Related: Watch next-generation lightweight spacesuit tested on Zero-G flight (photos, video)

Space.com: What sorts of experiences were you able to port from your time at NASA to Collins, to help with the development?

Danny Olivas: I've been an engineer for over 35 years. I've always been fascinated about space. It is very much like coming home and being part of an engineering family where we toil away to produce things that are safe, efficient and effective for our clients.

The intent is basically, "right design" this suit. It should be a suit that is intuitive to the astronauts. So I feel like what I'm bringing to the table is essentially helping the engineers understand what is important, where do things need to be placed, what are the things that you need to be considering. For example, in December of last year, we completed an exercise called the "concept of operations." That essentially is evaluating the suit in an environment like you're integrated onto a spacewalk and then coming back from doing a spacewalk.

I was able to bring to the table: when we do our prep and post, here's what we do. Here's what we did on orbit. Here's how we work to this particular issue. Through that exercise, it provided feedback directly to the engineers on how to move forward. It's not a one and done thing. It's a collaboration: we've gone, and taken a look at that, and we can do this or we can't do that.

Related: Shuttle astronaut Danny Olivas talks diversity on Earth (and space) in 'Virtual Astronaut' webcast

I feel like I'm bringing everything I can to this. This likely going to be my last job, and I'm going to be on the field. I care about the astronauts: that we're building the spacesuits for the people who got me five spacewalks, and did so in a safe manner. I owe it to them, to give back to the engineering community: everything I can to help our team be successful and provide the safest and most efficient, most effective spacesuit for the next generation of explorers. That's the very least I owe for being given the opportunity.

Space.com: Can you step us through the development?

Olivas: Collins, with our partners ILC Dover Astrospace and Oceaneering, use heritage or legacy from the original Hamilton Standard suit technology, which is something that's been ingrained in the company DNA from the Apollo missions. The A7L spacesuit was the first one that was formed, all the way through the current EMU. It makes perfect sense that we are looking at extending to the next generation spacesuit for the International Space Station.

The intent is for NASA delivery and, at that point, we'll have a new suit on the space station that will not only be for the space station, but also will be applicable for other commercial destinations after ISS. That includes lunar landings as well; as you're familiar with, Axiom Space won the contract for the lunar suit and they're destined for their launch on (first moon landing) Artemis 3. We wish them the very best of luck. But we're also making a suit that's compatible with lunar applications. We look to be a continued competitor in the lunar space as well, because that is the future of exploration.

Space.com: What happened during the parabolic campaign?

Olivas: This campaign actually began over a year ago, when it was first decided that we would conduct a portion of the crew capability assessment in a microgravity environment. There's no 1 G equivalent that would give you confidence that the things that you would be doing could be applicable in microgravity. We looked at some of the more challenging things, such as airlock egress and ingress. Collins has built a mockup that was to scale.

Getting this this new suit across the hatch was vital to demonstrate that you have the ability to be able to do so, and the geometry of the suit would in fact actually go through there. So that was a big risk, especially if you consider that you only have a parabola to be able to demonstrate that. Sometimes getting in and out of the airlock can take upwards of a couple of minutes, but you don't get that liberty if you're doing a zero-G flight.

Related: I flew weightlessly on a parabolic flight to see incredible student science soar

The answer to that is practice, practice, practice, practice, practice, practice. We were literally, on a weekly basis, writing the choreography of what we would do on each and every parabola. Every team member was there. We knew where we were going to be positioned. The whole idea was that you want to be out of the way when it's time to go to the task, when there's limited time to be able to do that. And it worked flawlessly.

I learned some things. Trying to stand on your feet on a footplate makes it a bit challenging, so for me, it was trying to learn how to operate in this I would call it a bronco, if you will. Certainly there were oscillations. But we were still able to demonstrate that you could get inside a portable foot restraint within 20 seconds.

Space.com: Can you give a comparison about what it's like to be working in the current EMU compared with what Collins is going to be able to offer?

Olivas: From the outside, probably not a lot. You're going to see two arms, two legs, a helmet and a layer of white. The secret sauce is below that layer of white. There's no technology that's carried over from the EMU, but what has been carried over is all the lessons learned against this concept in doing this from day one. We bring all that experience and heritage with the suit into the development designers.

Now let's talk about the difference between the EMU and the next generation suit. It is like night and day. I'm talking strictly right now from the PGS the pressure garment system, the mobility aspect of it. Things that would lock you up in the suit on orbit. By the way, lockup issues especially with shoulder joints are part of the reason why we had an injury rate.

As we think of accessibility to the lunar application, we have intentionally gotten rid of a component called the waist bearing assembly, the ability to essentially pivot around the waist. In exchange we have introduced hip joints, joints which work in unison to allow for walking. This gives us a lot more flexibility in the lower extremities. I think the increasing range of motion, increased maneuverability are probably the biggest attributes that I've seen.

Space.com: Anything else would you like to add?

Olivas: I would say, help me carry forward the message about what the suit is. As much as this machine is to keep the human being alive in the space like solo spacecraft it's the contributions that make it right. It's all those engineers who go through kind of an anonymous perspective in their entire career, and you're never really knowing what they do. But it just happens because of a human being behind it. That team, I'm part of today, and I want to make sure that that becomes clear.

This interview was edited and condensed. This article was amended at 2:15 p.m. EST Feb. 14 to add information about other companies involved with the Collins spacesuit and to address a typo.

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This astronaut took 5 spacewalks. Now, he's helping make spacesuits for future ISS crews (exclusive) - Space.com

Unlocking the Genetic Puzzle of Obesity Across Sexes and Ages – SciTechDaily

A study has identified genes that influence obesity risk differently across sexes and age groups, offering new insights into the biological pathways of obesity. These discoveries underscore the importance of considering sex and age in obesity research and could lead to new treatments.

Researchers have discovered genes that impact obesity risk differently in men and women and across various ages, revealing potential new pathways for understanding and treating obesity.

From influencing how our body stores fat to how our brain regulates appetite, hundreds of genes, along with environmental factors, collectively determine our weight and body size. Now, researchers add several genes, that appear to affect obesity risk in certain sexes and ages, to that list. The study, published in the journal Cell Genomics, may shed light on new biological pathways that underlie obesity and highlight how sex and age contribute to health and disease.

There are a million and one reasons why we should be thinking about sex, age, and other specific mechanisms rather than just lumping everyone together and assuming that disease mechanism works the same way for everyone, says senior author John Perry, a geneticist and professor at the Wellcome-MRC Institute of Metabolic Science, University of Cambridge, U.K. Were not expecting people to have completely different biology, but you can imagine things like hormones and physiology can contribute to specific risks.

To untangle sexs role in obesity risk, the research team sequenced the exomethe protein-coding part of the genomeof 414,032 adults from the UK Biobank study. They looked at variants, or mutations, within genes associated with body mass index (BMI) in men and women, respectively. Based on height and weight, BMI is an estimated measurement of obesity. The search turned up five genes influencing BMI in women and two in men.

Researchers identified age-specific and sex-specific obesity genes by looking into the genome of 414,032 people from the UK. Credit: Cell Genomics/Kaisinger et al.

Among them, faulty variants of three genesDIDO1, PTPRG, and SLC12A5are linked to higher BMI in women, up to nearly 8 kg/m more, while having no effect on men. Over 80% of the women with DIDO1 and SLC12A5 variants had obesity, as approximated by their BMI. Individuals carrying DIDO1 variants had stronger associations with higher testosterone levels and increased waist-to-hip ratio, both risk indicators for obesity-related complications like diabetes and heart disease. Others with SLC12A5 variants had higher odds of having type 2 diabetes compared with non-carriers. These findings highlight previously unexplored genes that are implicated in the development of obesity in women but not men.

Perry and his colleague then repeated their method to look for age-specific factors by searching for gene variants associated with childhood body size based on participants recollections. They identified two genes, OBSCN and MADD, that were not previously linked to childhood body size and fat. While carriers of OBSCN variants had higher odds of having higher weight as a child, MADD variant carriers were associated with smaller body sizes. In addition, the genetic variants acting on MADD had no association with adult obesity risk, highlighting age-specific effects on body size.

Whats quite surprising is that if you look at the function of some of these genes that we identified, several are clearly involved in DNA damage response and cell death, says Perry. Obesity is a brain-related disorder, whereas biological and environmental factors act to influence appetite. Theres currently no well-understood biological paradigm for how DNA damage response would influence body size. These findings have given us a signpost to suggest variation in this important biological process may play a role in the etiology of obesity.

Next, the research team hopes to replicate the study in a larger and more diverse population. They also plan to study the genes in animals to peer into their function and relationship with obesity.

Were at the very earliest stages of identifying interesting biology, says Perry. We hope the study can reveal new biological pathways that may one day pave the way to new drug discovery for obesity.

Reference: Large-scale exome sequence analysis identifies sex- and age-specific determinants of obesity by Lena R. Kaisinger, Katherine A. Kentistou, Stasa Stankovic, Eugene J. Gardner, Felix R. Day, Yajie Zhao, Alexander Mrseburg, Christopher J. Carnie, Guido Zagnoli-Vieira, Fabio Puddu, Stephen P. Jackson, Stephen ORahilly, I. Sadaf Farooqi, Laura Dearden, Lucas C. Pantaleo, Susan E. Ozanne, Ken K. Ong and John R.B. Perry, 2 August 2023, Cell Genomics. DOI: 10.1016/j.xgen.2023.100362

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Unlocking the Genetic Puzzle of Obesity Across Sexes and Ages - SciTechDaily

Nasa builds towards new space stations – Electronics Weekly

The US Space Agency highlights the work of its three competing commercial space station partners Axiom Space, Orbital Reef and Starlab for the design and development of possible new orbital destinations.

We are ending the year on a high note with multiple important milestones being completed by our partners, said Angela Hart, manager of the Commercial Low Earth Orbit Development Program at NASA Johnson Space Center. Over the past few months, we have been able to dig into the details of the specific hardware and processes of these stations and are moving forward to multiple comprehensive design reviews next year.

For example, Axiom Space, which holds a firm-fixed price, indefinite-delivery, indefinite-quantity contract with NASA, is on schedule to launch and attach its first module, says the agency. The module is named Axiom Hab One, and is due to attach to the International Space Station in 2026.

Four modules are planned for the Axiom Commercial Segment attached to the station. And after the space stations retirement, the Axiom Commercial Segment will separate and become a free-flying commercial destination, named Axiom Station.

The hatches of the Axiom Hab One module are fabricated and prepared to undergo pressure testing to ensure a strong enough seal to withstand the vacuum of space, writes Nasa. Manufacturing of the Axiom Hab One module is underway, and the critical design review will occur in 2024. During this review, NASA will assess the maturity of the Axiom Space design and provide feedback necessary to ensure safe operations when it is attached to the International Space Station.

The Jeff Bezos-backed Blue Origin, which was awarded a contract by Nasa in 2021 to develop a free-flying space station named Orbital Reef, has also recently completed tests, reports the agency for a window system and a structural demonstration. It writes:

For the structural test, Blue Origin used a prototype of their space stations main module, called the Core, to demonstrate the manufacturing processes required to build the final pressurized modules of the station. The test supports validation of the structural models and analytical tools for the Cores structural design.

The International Space Stations cupola, a room with seven windows overlooking the Earth, is the cornerstone of crewed missions for both research and astronaut morale. Orbital Reef will incorporate multiple windows on its Core, with each window spanning about twice the size of a car windshield. For the window test, Blue Origin evaluated the window integration structure design concept and its performance against the pressures and temperatures the windows will be exposed to while in orbit.

The third example given of progress for a new space station involved Starlab, a station being developed by Voyager Spaces Exploration Segment, in partnership with Airbus and Northrop Grumman.

Voyager Space recently completed three milestones, said the North American agency: a system definition review and the initiation of two pairs of milestones for an optical link demonstration and alternative urine processor demonstration.

Free-space optical, also called laser communications, allows for higher data rates and more energy-efficient communications than radio frequency communication systems. A major goal of the optical communication demonstration is to conduct testing from the International Space Station to the ground to establish the capabilities needed for Starlab. This initial milestone, within the optical link demonstration milestone pair scope, validated the Starlab testing plan. The optical link is planning to be tested next on the International Space Station.

You can read more on the Nasa website.

The ISS is expected to be deorbited by a dedicated NASA spacecraft in 2031.

Image: Axiom Space A hatch of the Axiom Hab One module, which will attach the module to the ISS.

See also: Nasa invites students to rise to 2024 Human Exploration Rover Challenge

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Nasa builds towards new space stations - Electronics Weekly

How COVID and steroids are affecting the hips in young adults – IndiaTimes

In a surprising turn of events post-COVID-19, doctors are noticing a rise in cases of Avascular Necrosis (AVN), a condition causing the death of bone tissue, particularly in the hips. What's more surprising is that this is happening to a much younger crowd, people between 20 to 40 years old, whereas it used to be more common in people in their forties or fifties. If you have been treated for COVID-19 in the past and are now experiencing hip joint pain- early detection could help you! This is not only a red flag for old people but also younger demographic. Why is this occurring? Steroids were used even earlier for the treatment of conditions like asthma, arthritis, certain malignancies, and various other inflammatory conditions. It was an important risk factor for the development of AVN even then, albeit the incidence was lesser and the condition was much slower in disease progression. On the contrary, we are observing that patients who were affected with COVID and received steroid treatment, even for a short duration and with a lower dose are presenting with a much rapid destruction of the joint. This implies that its not just the steroid therapy but also the hypercoagulability and other vascular-related pathologies associated with COVID-19 that are contributing to the musculoskeletal damage. It is unpredictable as to which patient can develop this dreaded complication.

So what are the tell-tale signs to watch out for? It is predominantly pain in the hips, worsening on weight bearing and sometimes occurring even at rest. In the initial stages, it could be asymptomatic. Early detection, helps us identify this condition sooner and take measures to slow down the progression. AVN progresses through multiple stages and may not be detected on X-rays in the initial grade. It can be identified on the x-ray, usually in stage 2 or 3 when there is already a collapse of the femoral head (the ball in the hip joint). MRI is the only diagnostic tool that helps us pick up the disease in the initial stages of the pathology. When identified early, patients could benefit from joint preservation procedures like decompression surgery combined with stem cell therapy that can salvage the hip joint. Total hip replacement is recommended for those with collapse of the joint and irreversible damage as in stage 3.

Importance of Breathing Exercises

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How COVID and steroids are affecting the hips in young adults - IndiaTimes

DeepSouth: A Revolutionary Supercomputer for Simulating the Human Brain | 2024 Launch – Medriva

In an ambitious leap forward in computational neuroscience, a supercomputer designed to simulate the entire human brain is set to become operational in 2024. This cutting-edge development, named DeepSouth, holds the potential to revolutionize our understanding of the human brain and advance the field of neuroscience.

Set to switch on in 2024, DeepSouth is the worlds first supercomputer capable of simulating networks at the scale of the human brain. Using a neuromorphic system that mimics biological processes, it can perform a staggering 228 trillion synaptic operations per second. This system is purpose-built to operate like networks of neurons, demanding less power and facilitating greater efficiencies. The supercomputer is a collaboration between Western Sydney University, the University of Sydney, the University of Melbourne, and the University of Aachen in Germany.

This unprecedented development is expected to lead to significant advances in smart devices, sensors, and AI applications. But perhaps the most profound impact of DeepSouth will be its contribution to our understanding of the healthy and diseased human brain. By replicating the brains neural network and cognitive functions, the supercomputer paves the way for groundbreaking insights into brain disorders and neurological conditions.

DeepSouth is not the only attempt at creating a biological computer. Researchers worldwide are exploring the possibility of building computers powered by actual brain cells. Such advancements could potentially create a cyborg brain vastly more powerful than our own. The hope is to better understand how brains can use such little power to process vast amounts of information.

DeepSouth is part of a larger initiative known as the Human Brain Project. This multinational collaboration aims to simulate the entire human brain by 2024. The goal is to delve deeper into the brains functions and develop new treatments for brain-related diseases. This ambitious project has garnered significant attention from the scientific community and offers a promising direction for future research.

In conclusion, the advent of a supercomputer capable of simulating the entire human brain signals a new era in neuroscience and AI research. As we await the operational launch of DeepSouth in 2024, the scientific community and the world at large watch with bated breath, eager to witness the revolutionary insights this development will bring to our understanding of the most complex organ in the human body. The future of neuroscience holds exciting possibilities and is poised for unparalleled growth and discovery.

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DeepSouth: A Revolutionary Supercomputer for Simulating the Human Brain | 2024 Launch - Medriva

The Future of Neuroscience and AI: DeepSouth Supercomputer – Medriva

Stepping into the Future with DeepSouth

The world is on the brink of a significant breakthrough with the development of DeepSouth, the first-ever supercomputer capable of simulating the entire human brain. This trailblazing project, under the leadership of Western Sydney University in Australia, is set to revolutionize neuroscience and artificial intelligence as we know it. With an operational launch date set for 2024, DeepSouth is poised to unlock a myriad of opportunities in medicine, technology, and beyond.

DeepSouth isnt just another supercomputer it is a powerhouse that matches the human brains estimated rate of operations. With the ability to perform 228 trillion synaptic operations per second, it is set to redefine what technology can achieve. Its not just about the staggering numbers; its about how DeepSouth uses this power. The supercomputer is designed to process colossal amounts of information with minimal power, emulating the efficiency of the human brain.

What sets DeepSouth apart is its neuromorphic system. Unlike traditional computer systems, the neuromorphic system is designed to operate like networks of neurons. This unique configuration allows the supercomputer to emulate large networks of spiking neurons efficiently, requiring less power and enabling greater efficiencies. This ingenious design is what makes the simulation of the entire human brain possible.

DeepSouth is expected to be a game-changer for neuroscience and AI. By simulating the human brain, it will provide unprecedented insights into how our brains process information so efficiently. These findings could lead to breakthroughs in understanding both healthy and diseased human brains, opening new avenues for medical research and treatment. The supercomputer will also be an invaluable resource for researchers looking to prototype new engineering solutions in the AI space.

While the implications for neuroscience are profound, the potential applications of DeepSouth dont stop there. The project could lead to advances in smart devices and sensors, further enhancing the technology that forms an integral part of our lives. With AI applications becoming increasingly prevalent, the insights derived from DeepSouths brain simulations could pave the way for more sophisticated AI systems, pushing the boundaries of what technology can achieve.

As we look forward to DeepSouths operational launch in 2024, its clear that were on the cusp of a new era in technology and neuroscience. This supercomputer isnt just simulating the human brain; its unlocking the potential to understand our brains better, develop more advanced AI, and create smarter technology. The future of neuroscience and AI is bright, and DeepSouth is leading the charge.

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The Future of Neuroscience and AI: DeepSouth Supercomputer - Medriva

Argentina: Santa Fe Province approves online gambling and sports betting – Yogonet International

The Senate of the Province of Santa Fe sanctioned on Thursday 14 several bills sent by the Executive Power, headed by Governor Maximiliano Pullaro. Among these proposals was the one that regulates the activity of online gambling.

During the Extraordinary Session N 1 of the 141st Period, presided over by Vice Governor Gisela Scaglia, online gambling was enabled when the Senate accepted the preliminary approval from the Chamber of Deputies, without modifications.

The approved initiative "establishes a regulation for the development and exploitation of the activity of games of chance, sports betting, and sports forecasts, online or with virtual modality, which are carried out through digital, electronic, computerized, telematic, interactive, telecommunication means and platforms, and those to be developed in the future", the Senate stated.

Bill 52.665, promoted by Deputy Fabin Basta -currently Pullaro's Minister of Government- and introduced by his peer Marcelo Gonzlez (both from UCR Evolucin), was approved by the Chamber of Deputies on Thursday, November 30.

With a wide majority in the Lower House and unanimity in the Upper House, the new regulation comes to overcome Decree 1451 of November 20, 2020, which, with the signature of then Governor Omar Perotti, enabled online gambling under the idea that it was only a "modality" of an already existing legalization.

During the pandemic, the opposition did not understand it this way since, from their point of view, the powers of the provincial Legislature had been subjugated. Three years ago, Pullaro and Basta, at that time deputies, initiated a lawsuit against Perotti, which now the online gambling law will probably make the issue become "abstract".

Although the idea of Basta and Gonzlez's project was to correct Perotti's regulation, the initiative has some novelties, such as the authorization of sports betting, the increase of the tax from 10% to 15% of the gross results, and a special containment to the agencies, to whom a part of the benefits will be allocated.

In addition, 50% of the money raised will be allocated to campaigns for the prevention and awareness of compulsive gambling.

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Argentina: Santa Fe Province approves online gambling and sports betting - Yogonet International

Metaverse cloning tech uses AI to create virtual versions of you that live in games you cant always c… – The Sun

ARTIFICIAL intelligence cloning is poised to become the next big thing in the technology sector - and maybe even our lives.

Meta recently unveiled its AI-powered chatbots and many of them feature likenesses of celebrities - or celeb AI clones.

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This is thanks to its Llama 2 technology, which can generate AI "characters" or "animations" based on real people.

Another company called Delphi lets users create virtual clones of themselves or anyone else.

To generate an AI clone via Delphi, all users need to do is upload some form of identification and as many as thousands of files, including emails, chat transcripts, and even YouTube videos.

It's apparent that this technology is quickly taking over the industry and this is only the beginning, experts say.

MichaelPuscar, Co-founder ofAI firm NPCx, which is developing its own AI cloning technology for the gaming sector, explains the phenomenon further.

"Our aim is to allow video game players toclonethemselves into video games, acting on their behalf in the game when theyre unavailable to play," he told The U.S. Sun in an email.

"You can imagine the following situation: you and I are set to play Call of Duty tonight but at the last minute, your partner unknowingly made a dinner reservation. Now Im stuck, or am I? Im not if I can play with or against yourclone," Puscar said.

NPCxs product is called BehaviorX, and it has not yet been released to the public, he said, but it could be central to the development of the metaverse.

The term metaverse was popularized by Meta CEO Mark Zuckerburg and describes a virtual world that combines social media, cryptocurrency, augmented reality, and gaming.

"Our clones need to exist in not just a video game environment but in the Metaverse as well," Puscar said.

"In both cases, the goal is such that when you interact with these clones they are in every way indistinguishable from the person from whom they were cloned."

To create theclones, NPCx asks players to play the game and observe them and their environment in great detail.

"We specifically ask them to take certain actions in the game, not unlike how actors are asked to take specific actions on a motion capture stage," Puscar said.

"This gives us what we need to train our models and create theclone."

Puscar added that by generating characters based on real-world people, the company can also create non-player characters (NPCs) with deep personalities, who act and react in realistic ways.

When asked what the appeal of AI clones is in gaming, Puscar had a simple answer.

"For gamers, playing alongside or againstAIclonesof real-world players orcelebritiesadds an element of realism and excitement to the gaming experience," he said.

"It's about creating a more engaging, interactive, and personalized form of entertainment that resonates with the user's interests and preferences."

Beyond gaming and chatbots, Puscar anticipates seeing AI cloning technology employed in a variety of applications.

"This could include virtual training environments, interactive educational tools, personalized digital assistants, and more," he said.

"The entertainment industry, in particular, stands to benefit significantly, with possibilities ranging from personalized movie experiences to virtual concerts featuring digitalclonesof artists.

Still, while this all sounds like good fun, the ethics around digitalclonesare "perilous," Puscar explained.

"Once youve trained yourclone, your likeness is acting in ways out of your control. In theory, if the algorithms are working properly, it is acting in ways that you would act," he said.

"But we cannot control the counterparty, and you can imagine situations where someone nefarious decides to simulate sexual acts with aclone, uses profane language, or otherwise attempts to put them into compromising situations."

Therefore, it is imperative to make sure thatclonesare created and used ethically, he said.

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Metaverse cloning tech uses AI to create virtual versions of you that live in games you cant always c... - The Sun

Students need to stop turning their backs on liberal arts degrees – North Texas Daily

The pressure to pursue a STEM major in college has steadily grown over the years, causing the arts and humanities to be overshadowed in exchange. The liberal arts are a necessary pillar of education that deserves to be valued and maintained.

The number of jobs requiring STEM qualifications has surged by 34 percent over the past decade, according to the U.S. Chamber of Commerce Foundation. Students have been told sciences are the future of our world and the most practical thing to study in college. Following that advice is usually at the disparagement of a liberal arts education, calling it a "useless degree."

The notion of a useless degree is misperceived because any form of education and learning will never be useless, and a liberal arts education is valuable. Most people who belittle arts and humanities usually do so from a place of ignorance. They misconstrue the liberal arts as being associated with the modern political idea of liberalism, or the opposite of being conservative.

Rather, the term liberal arts refers to the Latin word liberalesmeaning "free," as opposed to "subjugation" or "enslavement." The term was used during the Middle Ages to distinguish from the servile arts, which were vocational careers such as medicine, engineering and business. The liberal arts were considered the education of a free person in society unconstrained by the sole purpose of production, with the ability to learn liberating knowledge.

The fundamentals of a liberal arts education are grounded in the idea of broad interdisciplinary teachings that serve to create critical thinkers who recognize the interconnectedness of all knowledge. This form of education should be applied and taught to all majors, and would especially benefit the sciences. Being able to relate formulas and numbers to the arts and humanities would help foster creativity, innovation and remind students of the human aspect of their disciplines.

Instead, universities and their federal funding are adopting a hard stance on turning colleges into vocational schools, investing more within their STEM departments and phasing out the arts. The National Endowment for the Humanities budgetwas only$180 million in 2022, and the National Science Foundations budget lapped that number by 50 times, according to The New York Times. The future of higher education is now blindsided with the prospect of creating a world of scientists and business professionals, approaching students as cogs needed to fit within the business world framework instead of as learners.

Even politicians are pushing toward the death of liberal arts education. Miguel Cardona, the current secretary of education, said Every student should have access to an education that aligns with industry demands and evolves to meet the demands of tomorrow's global workforce. Insinuating the sole reason for education is to meet industry demands instead of self-fulfillment or the development of moral virtues, qualities philosophers like Socrates and Aristotle intended education to create for individuals.

What these advocates of a strict STEM paradigm fail to recognize is that only some are suited for science and math. Whether it is because they do not find enjoyment within the numbers or they simply do not have the predisposition for a mathematical aptitude, no one should feel pressured by industry demands or STEM job qualifications.

Students should pursue whatever major they are passionate about or what brings them enjoyment. The construct that some majors are better than others or prepare you for life better needs to be reevaluated. Most majors within the arts and humanities focus on the human aspect of their disciplines and are well-versed in soft skills such as communication, adaptability and creativity. Eighty-nine percent of recruiters in LinkedIns 2019 Global Talent Trends report claimed people who did not get hired lacked these skills.

Although many value the sciences as being more vital to society than the arts, the need to value the cultivation of culture and the understanding between people that the liberal arts establish must always remain a priority within education. After all, what is the point of doctors saving lives and engineers crafting towers if there is not music to be heard or art to witness?

That begins with universities and federal organizations recognizing the importance of a liberal arts education and implementing more funding and opportunities for liberal arts colleges. Core requirement courses must extend to include more classes within the humanities and arts for STEM majors to foster a holistic education rather than a technical one.

Steve Jobs said it best: Technology alone is not enough. It is technology married with liberal arts, married with the humanities, that [] make[s] our heart sing.

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Students need to stop turning their backs on liberal arts degrees - North Texas Daily