12345...102030...


The 2018 Red Hot Calendar Is Looking For More Sexy Redheads For Us To Swoon Over – NewNowNext

by Dan Avery 1h ago

If youve followed Thomas Knights Red Hot series, you know he has a gift for capturing beautiful redheads. Over five years, four calendars, an art exhibit, and two coffee table books, Knights has given us some of the most stunning carrot-tops in nature.

Red Hot/Thomas Knights

Now he and art director Elliott James Freize are getting ready to shoot the 2018 Red Hot British Boys calendar, and theyve put out a model call. (Because theres nothing quite like a ginger in the wild, right?)

We are looking for nine buff ginger men based in the UK to join our three Red Hot British BoysRob, Alex and Chrisin the 2018 calendar, Knights says in a press release. You need to have a handsome face, great body and awesome personality, natural red hair and a British accent and also be available to shoot in London in July.

Red Hot/Thomas Knights

If you or someone you know fits the bill, reach out to Knight and Freize (and also, send us naughty picsit wont improve your chances of getting in the calendar but itll make our week).

Knights says redheaded guys have always had a place in gay cultureeven if its a bit fetishized, their rarity is seen as asset, not a curse. Theyre ready-and-willing to see empowered sexual ginger guys flaunting it, he tells NewNowNext.

Whats been interesting in the last few years is that straight culture is finally, after years of us campaigning, coming along for the ride, he adds.

Red Hot/Thomas Knights

We are seeing more ginger guys in advertising campaigns playing the lead man rather than the nerdlast year half our calendar sales and half our Facebook followers were women. Its a totally unprecedented shift that we werent expecting. The other week we were on the cover of Daily Star which I think means we have permeated the mass market. Finally sexy ginger guys are an actual thing.

Red Hot/Thomas Knights

A portion of proceeds from next years calendar benefit the Ben Cohen Standup foundation, which helps support those doing real-world work to eradicate bullying, especially in the LGBT community. You can support the 2018 Red Hot British Boys calendar on Kickstarter through July 1.

Editor in Chief of NewNowNext. Comic book enthusiast. Bounder and cad.

Here is the original post:

The 2018 Red Hot Calendar Is Looking For More Sexy Redheads For Us To Swoon Over – NewNowNext

Research Check: can a new drug really protect redheads from cancer? – EconoTimes

A recently published US study on an experimental drug that leads to tanning without sun exposure has generated a host of headlines around the world.

Some went with what the drug means for redheads, with the headline:

Good news for redheads: Cream can give even the lightest skin a tan WITHOUT exposure to harmful UV radiation

Others went for the drugs apparent protection against skin cancer:

Suntans for all: chemical causes any skin to tan and protects against cancer

Some coverage was more measured:

Scientists create chemical that changes skin colour without tanning

You can read more examples here.

So, does the medias reporting of the study, published in the journal Cell Reports, reflect the actual research?

The studys senior author David Fisher, professor of dermatology at Harvard Medical School, said, of the reports he had read, the coverage was generally accurate and balanced:

I have not seen any problems (yet) No particular gaps either.

However, we found the fact the drug wasnt tested on live humans, but in mice, was generally buried in media reports. And most coverage failed to mention the researchs real potential, in treating other conditions.

The Conversation, CC BY-ND

Skin cancers account for around 80% of all new cancers in Australia, with most caused by overexposure to the sun.

Skin cancers are more common in people with pale skin. And with more than two million Australians getting sunburnt every summer weekend, its no wonder interest in damage-free, UV-protective tanning is high.

How was the study conducted and what did it find?

The researchers wanted to manipulate the pathway that leads to pigment (melanin) production to see if this could induce tanning. In particular, they hoped to activate the MITF gene, the master-regulator of skin pigment production.

They built on their earlier work identifying a group of molecules known as salt-inducible kinase inhibitors (or SIKi for short) that could do this.

First, the researchers grew pigment-producing cells (melanocytes) in a flask in a laboratory and treated them with the SIKi drug or a control substance. They then checked what happened to the MITF gene.

The SIKi prompted a 400% increase in gene activity plus pigment production (basically, like tanned cells in a flask). So, the researchers moved on to experiments in mice.

They chose yellow-haired mice, which were specially bred to have defects in the same gene causing red hair and easily-burned skin in humans. In effect, they were redhead mice.

The researchers waxed the mice to make a patch of bare skin they treated either with a lotion containing SIKi or plain lotion, applied daily. They also measured skin colour daily. The researchers also took samples of skin and looked at them under the microscope.

There was very noticeable darkening (pigmentation) in the mice treated with the SIKi but not with the control lotion. The darkening gradually increased over the six days of treatment and then gradually faded over two weeks, much like a natural suntan. The mice appeared to have no obvious ill effects.

Microscopic examination of the darkened skin showed the melanin had settled in caps over the nucleus of the cells, just as melanin produced after sun exposure would. So, theoretically it should protect the cells DNA in much the same way as naturally produced melanin would.

Then, the researchers used a modified form of the SIKi that would be more easily absorbed to see its effects on healthy human skin. Rather than applying it directly to someones arm or leg, the researchers used leftover breast skin from reconstructive surgery and cultured it in petri dishes to keep it alive. The darkening also increased gradually.

Human skin was treated with a control substance (left), a SIKi that couldnt penetrate the skin (centre) and the new-version SIKi (right). Cell Reports/Nisma Mujahud and David Fisher

How should we interpret the findings?

While other drugs like Melanotan-II promote tanning, they are usually delivered by injection. So, finding a way to skip both the UV and a needle makes the SIKi research very biologically interesting. But in terms of medical use, these results are very early in the testing process.

The SIKis have yet to be tested on whole humans (not just loose patches of skin) to check for the effects of the drug leaking into the rest of the body, or discomfort from the drugs action on the skin.

News outlets followed the research teams lead in speculating a topical SIKi could help protect against skin cancer. However, these claims may be over-egged, as a tan is only as protective as SPF 2-4 sunscreen.

Using a SIKi cream might help reduce a persons cancer risk if it steers them away from risky behaviour like sunbathing or using solariums, but case reports suggest people might assume they can have more UV exposure once they are tanned, with cancerous results.

However, Fishers idea of including a SIKi in a traditional sunscreen might help combat this.

What about those headlines?

Headlines like Suntans for all and Risk-free tanning are jumping ahead of the research. But fortunately most articles note the human research has so far only been done in a petri dish.

The emphasis on tanning for redheads is also overdone in some articles. But most mention deeper in the article the redheads were really mice.

Most articles also note Fisher envisions SIKi being used with normal sun-protection measures like sunscreen, rather than instead of them, and safety still needs to be assessed.

The Guardian quoted Fisher saying:

Its obviously critical that safety and toxicity studies need to be done This is not a toy, its not a cosmetic.

Could these drugs have other uses?

One little-reported aspect is SIKis also have potential as a treatment for diseases causing severe sun-sensitivity, like erythropoietic protoporphyria, or anomalies in skin pigmentation, like vitiligo. People with these under-researched conditions might be the real winners from a UV-free tanning cream.

In the meantime, the advice remains to slip, slop, slap, seek and slide whenever the UV index reaches three or higher daily from September to April in Australias southern states and all year round further north. You can also use the SunSmart app to find out todays UV index and sun protection times in your area. Katie Lee and Richard Sturm

Peer review

As this Research Check clarifies, the study into activating a gene to increase skin pigmentation was performed in mice and isolated human skin. This analysis also echoes the researchers comment that the drug has never been tested in humans and would require careful considerations of safety.

Such considerations might include whether activating the gene could trigger cancer, as the researchers suggest could occur in certain circumstances.

If safe, as the Research Check says, it would be more convenient to be apply a drug to the skin rather than injecting it. And although more pigmented skin reduces the risk of skin cancer with sun exposure, the protection is only the equivalent of SPF 2-4 sunscreen. So I agree with Fisher that, if safe, the drug could only be used in addition to other skin protection measures.

The real issue is all this talk of risk and benefit is simply in pursuit of a fashion, said to have been started by fashion designer Coco Chanel. It is not a universal fashion as in South East Asia pale skin is more highly sought.

Perhaps the more effective protection against cancer is to change Western fashion and promote the message that pale skin and red hair is beautiful too. Ian Olver

Katie Lee is supported by funding from NHMRC, Epiderm Foundation, Queensland Genomic Health Alliance and the Queensland Cancer Council.

Richard Sturm currently receives funding from the Australian NHMRC, Queensland Cancer Council, Queensland Genomic Health Alliance and the Epiderm Foundation. In the past he has been the recipient of ARC Discovery grant funding.

Ian Olver sits on the NHMRC Council.

New Study Could End Insulin Dependence Of Type-1 Diabetics

Infertility in men could point to more serious health problems later in life

Electrically stimulating your brain can boost memory but here’s one reason it doesn’t always work

Fainting and the summer heat: Warmer days can make you swoon, so be prepared

Why bad moods are good for you: the surprising benefits of sadness

Here’s why ‘cool’ offices don’t always make for a happier workforce

Four myths about diabetes debunked

What are ‘fasting’ diets and do they help you lose weight?

Placebos work even when patients know what they are

Read the original post:

Research Check: can a new drug really protect redheads from cancer? – EconoTimes

Forex technical analysis: AUDUSD heads toward 200 hour MA … – ForexLive

The AUDUSD is moving lower in reaction to the dollars strength today (and lower commodity prices – thanks Bud), and in the process is approaching key support defined by the 200 hour MA at 0.75707 and the low extreme of the “red box” that has defined the range since June 14th. There are two tests of the low extreme and three tests of the higher extreme. The low of the “red box” dovetails the high extreme from an earlier “blue box” (see chart below).

Look for buyers against key support area (risk is defined and limited and the 0.7566 is a key level), but expect stops on a break below. If the support holds, getting back above the 0.7584 lows from yesterday and today will be eyed…

Original post:

Forex technical analysis: AUDUSD heads toward 200 hour MA … – ForexLive

Research Check: can a new drug really protect redheads from cancer? – The Conversation AU

The study looked at helping redheads to tan and protect them from the sun. But the redheads were mice, not humans.

A recently published US study on an experimental drug that leads to tanning without sun exposure has generated a host of headlines around the world.

Some went with what the drug means for redheads, with the headline:

Good news for redheads: Cream can give even the lightest skin a tan WITHOUT exposure to harmful UV radiation

Others went for the drugs apparent protection against skin cancer:

Suntans for all: chemical causes any skin to tan and protects against cancer

Some coverage was more measured:

Scientists create chemical that changes skin colour without tanning

You can read more examples here.

So, does the medias reporting of the study, published in the journal Cell Reports, reflect the actual research?

The studys senior author David Fisher, professor of dermatology at Harvard Medical School, said, of the reports he had read, the coverage was generally accurate and balanced:

I have not seen any problems (yet) No particular gaps either.

However, we found the fact the drug wasnt tested on live humans, but in mice, was generally buried in media reports. And most coverage failed to mention the researchs real potential, in treating other conditions.

Skin cancers account for around 80% of all new cancers in Australia, with most caused by overexposure to the sun.

Skin cancers are more common in people with pale skin. And with more than two million Australians getting sunburnt every summer weekend, its no wonder interest in damage-free, UV-protective tanning is high.

The researchers wanted to manipulate the pathway that leads to pigment (melanin) production to see if this could induce tanning. In particular, they hoped to activate the MITF gene, the master-regulator of skin pigment production.

They built on their earlier work identifying a group of molecules known as salt-inducible kinase inhibitors (or SIKi for short) that could do this.

First, the researchers grew pigment-producing cells (melanocytes) in a flask in a laboratory and treated them with the SIKi drug or a control substance. They then checked what happened to the MITF gene.

The SIKi prompted a 400% increase in gene activity plus pigment production (basically, like tanned cells in a flask). So, the researchers moved on to experiments in mice.

They chose yellow-haired mice, which were specially bred to have defects in the same gene causing red hair and easily-burned skin in humans. In effect, they were redhead mice.

The researchers waxed the mice to make a patch of bare skin they treated either with a lotion containing SIKi or plain lotion, applied daily. They also measured skin colour daily. The researchers also took samples of skin and looked at them under the microscope.

There was very noticeable darkening (pigmentation) in the mice treated with the SIKi but not with the control lotion. The darkening gradually increased over the six days of treatment and then gradually faded over two weeks, much like a natural suntan. The mice appeared to have no obvious ill effects.

Microscopic examination of the darkened skin showed the melanin had settled in caps over the nucleus of the cells, just as melanin produced after sun exposure would. So, theoretically it should protect the cells DNA in much the same way as naturally produced melanin would.

Then, the researchers used a modified form of the SIKi that would be more easily absorbed to see its effects on healthy human skin. Rather than applying it directly to someones arm or leg, the researchers used leftover breast skin from reconstructive surgery and cultured it in petri dishes to keep it alive. The darkening also increased gradually.

While other drugs like Melanotan-II promote tanning, they are usually delivered by injection. So, finding a way to skip both the UV and a needle makes the SIKi research very biologically interesting. But in terms of medical use, these results are very early in the testing process.

The SIKis have yet to be tested on whole humans (not just loose patches of skin) to check for the effects of the drug leaking into the rest of the body, or discomfort from the drugs action on the skin.

News outlets followed the research teams lead in speculating a topical SIKi could help protect against skin cancer. However, these claims may be over-egged, as a tan is only as protective as SPF 2-4 sunscreen.

Using a SIKi cream might help reduce a persons cancer risk if it steers them away from risky behaviour like sunbathing or using solariums, but case reports suggest people might assume they can have more UV exposure once they are tanned, with cancerous results.

However, Fishers idea of including a SIKi in a traditional sunscreen might help combat this.

Headlines like Suntans for all and Risk-free tanning are jumping ahead of the research. But fortunately most articles note the human research has so far only been done in a petri dish.

The emphasis on tanning for redheads is also overdone in some articles. But most mention deeper in the article the redheads were really mice.

Most articles also note Fisher envisions SIKi being used with normal sun-protection measures like sunscreen, rather than instead of them, and safety still needs to be assessed.

The Guardian quoted Fisher saying:

Its obviously critical that safety and toxicity studies need to be done This is not a toy, its not a cosmetic.

One little-reported aspect is SIKis also have potential as a treatment for diseases causing severe sun-sensitivity, like erythropoietic protoporphyria, or anomalies in skin pigmentation, like vitiligo. People with these under-researched conditions might be the real winners from a UV-free tanning cream.

In the meantime, the advice remains to slip, slop, slap, seek and slide whenever the UV index reaches three or higher daily from September to April in Australias southern states and all year round further north. You can also use the SunSmart app to find out todays UV index and sun protection times in your area. Katie Lee and Richard Sturm

As this Research Check clarifies, the study into activating a gene to increase skin pigmentation was performed in mice and isolated human skin. This analysis also echoes the researchers comment that the drug has never been tested in humans and would require careful considerations of safety.

Such considerations might include whether activating the gene could trigger cancer, as the researchers suggest could occur in certain circumstances.

If safe, as the Research Check says, it would be more convenient to be apply a drug to the skin rather than injecting it. And although more pigmented skin reduces the risk of skin cancer with sun exposure, the protection is only the equivalent of SPF 2-4 sunscreen. So I agree with Fisher that, if safe, the drug could only be used in addition to other skin protection measures.

The real issue is all this talk of risk and benefit is simply in pursuit of a fashion, said to have been started by fashion designer Coco Chanel. It is not a universal fashion as in South East Asia pale skin is more highly sought.

Perhaps the more effective protection against cancer is to change Western fashion and promote the message that pale skin and red hair is beautiful too. Ian Olver

Visit link:

Research Check: can a new drug really protect redheads from cancer? – The Conversation AU

Ginger discount restaurant to open new bar…with booze deals for redheads – Daily Post North Wales

A restaurant which offers food discounts to redheads launches a new bar tonight – with special deals for gingers.

Gingers Grill in Prestatyn has been offering money off food to genuine carrot tops since opening exactly a year ago.

The offer, dreamt up by former ginger boss Mark Linaker, attracted global attention and remains a talking point for customers coming to the restaurant.

Now Mark is set to expand the site with a new upstairs bar opening tonight.

Mark – who has shaved off his own receding ginger hair – said the redhead discount will continue on selected ginger themed cocktails but added that beyond the gimmick this bar would bring something new to Prestatyn.

He said: The bar, named The Upstairs – will offer something that is not in the town at the moment, there will be open mic nights, lots of live music, folk nights, and also a 100inch screen for sports.

There will always be something different going on and we have a licence to 3am as well.

He added: The ginger discount has done so well for us that we will bring this upstairs with money off on ginger themed cocktails that we will develop.

The offer continues to make customers laugh, there isnt a day when we dont get a few comments on it and it makes people smile. Its a great talking point.

The addition of the bar will bring the total number of jobs at the site up to 14 and Mark hopes to expand the brand in the future.

He said: Over the year we have made changes here and there to the restaurant and we now feel we have everything the way we want it. We will now get the bar opened and then start to look at another site.

We are interested in coming to Bangor and think the brand would fit in well there but well first focus on getting the new bar right.

Originally posted here:

Ginger discount restaurant to open new bar…with booze deals for redheads – Daily Post North Wales

Redhead (bird) – Wikipedia

The redhead is a pochard, a diving duck specially adapted to foraging underwater. Their legs are placed farther back on the body, which makes walking on land difficult, the webbing on their feet is larger than dabbling ducks and their bills are broader, to facilitate underwater foraging. In addition, pochards have a lobed hind toe.[4] No pochard has a metallic coloured speculum, something that is characteristic of other ducks.[6]

During breeding season, adult males have a copper head and neck, with a black breast. The back and sides are grey, the belly is white and the rump and tail are a light black. Male bills are pale blue with a black tip and a thin ring separating the two colours. Non breeding males lose the copper colour and instead have brown heads.[5]

Adult females, however, have a yellow to brown head and neck. The breast is brown, the belly is white and the rest of the body is a grey to brown. The female bills are slate with a dark tip that is separated by a blue ring. Females remain the same colour year round.[5]

Redheads leave their winter range in late January and February with all birds migrating by mid-March. In western North America, migrants begin arriving in Oregon, British Columbia] and Colorado in February. In central North America, migrants arrive as soon as temperatures open wetlands and lakes, which can range from late February (Nebraska) to early May (Alberta, Manitoba and Iowa). In the Great Lakes region and north-eastern North America, migrants will also arrive as soon as bodies of water open up.[10]

Western birds migrate through Great Basin to the Pacific Coast. In British Columbia, fall migration begins in September and continues through October. The Great Salt Lake region is of particular importance to migrants in western United States. Central North American redheads will begin migrating earlier, around August/September and go through the Great Plains to the Texas coast. Eastern populations will migrate through the Great Lakes region to the Atlantic Coast or Florida from October to November. Most redheads winter along the Gulf of Mexico (offshore Louisiana, Florida and Mexico) however eastern populations will winter in South Carolina.[10]

Redheads flock together on lakes and other bodies of water but will migrate in pairs, which are formed in December or January through elaborate courtship rituals.[4] Unpaired redheads will migrate together in a courting party that can be up to 25 individuals strong and hopefully find a mate within the group.[4] The pair bonds are established yearly through a long courtship process. Males begin this process through neck-kinking and head throwing displays while emitting a cat-like call.[10] The male will continue by initiating a neck-stretching display while producing a cough like call, a display and vocalization in which the females reciprocates. If interested, the female will herself produce inciting calls towards the male while performing alternate lateral and chin lifting movements. The male then swims ahead of her and turns the back of his head towards the female.[4] Once courtship is finished, the two birds are paired for the year. Eventually, the male initiates copulation by alternating bill dipping and preening dorsally towards the female, an action in which the female might return to the male.[6]

Once copulation is completed, female redheads begin forming nests. They are built with thick and strong plant material in emergent vegetation, such as hard stem bulrush, cattails and sedges, over or near standing water.[4][8] Redheads to not defend their territory or home range and are actually very social while in their breeding ground. This is thought to occur because some younger, inexperienced redhead females parasitize other pochards.[4] Some redheads lay their eggs in other pochards nests, including the canvasback, ring-necked duck and greater and lesser scaups and this social parasitism by redheads reduces the hatching success of other pochards eggs, especially those of the canvasback.[4] In contrast, because of the parasitic relationship between the redhead and other pochards, redhead hybrids with the ring-necked duck, canvasback and the greater and lesser scaups have been found.[6]Canvasback x redhead hybrids can be fertile.[11] Brood sizes range from 5-7 young, with the mother abandoning the chicks at 8 weeks old, before they are capable of flying.[9] They remain flightless for another 24 weeks.[9]

There is little information on redhead vocalizations outside of breeding calls. Males will emit calls when courting the female.[6] When the neck is fully extended in the neck-stretching display, males will emit a distinct wheee-oww, which sounds catlike.[4][6] Males may also produce a soft coughing call, although this call is less frequent.[4] Females will emit a soft errrr note when she is inciting a male.[4]

All pochards have similar diets that include both plant and animal materials. Redheads undergo a niche switch when breeding and when wintering. During the breeding season, redheads will eat as much animal matter as possible, including gastropods, mollusks and insect larvae.[4][5] They will eat the occasional grass and other emergent vegetation.[5] However, once they fly south, redheads will change their diet to include mostly plant material, including pondweeds, wild rice, wild celery, wigeon grass, bulrushes, muskgrass and shoal grass.[4][5]

Gastropods known as food of Aythya americana include: Acteocina canaliculata, Acteon punctostriatus, Anachis avara, Anachis obesa, Caecum nitidum, Calliostoma sp., Cerithidea pliculosa, Cerithium lutosum, Crepidula convexa, Diastoma varium, Melanella sp., Mitrella lunata, Nassarius acutus, Nassarius vibex, Natica sp., Neritina virginea, Odostomia trifida, Olivella minuta, Olivella watermani, Polinices sp., Pyramidellidae, Pyrgocythara plicosa, Rissoina catesbyana, Sayella livida, Turbonilla sp., Turbonilla interrupta and Vitrinella sp.[12]

Read the original:

Redhead (bird) – Wikipedia

Red heads | Etsy

Get fresh Etsy trends and unique gift ideas delivered right to your inbox.

Please enter a valid email address.

Looks like you already have an account! Please Log in to subscribe.

You’ve already signed up for some newsletters, but you haven’t confirmed your address. Register to confirm your address.

You’ve been successfully signed up!

Great! We’ve sent you an email to confirm your subscription.

There was a problem subscribing you to this newsletter.

Read the original here:

Red heads | Etsy

The Red Heads – Home | Facebook

WHICH ONE WOULD YOU CHOOSE?

Un coup d’il au nouveau Merchandising de tourne! En direct de Copenhague! Merci encore aux Red Heads qui ont le rflexe de nous transmettre les infos LIVE, pour que nous puissions les partager avec toute la communaut! Vous tes les meilleurs!!! —–… A look at the new Tour Merchandising – Live from Copenhagen! Thanks again to the Red Heads who have the reflex to send us the LIVE info, so that we can share them with the whole community! You are the best!!! #celinedion

Read more:

The Red Heads – Home | Facebook

New tanning drug darkens skin, could reduce incidence of skin-cancer – NEWS.com.au

A new skin-darkening drug spells good news for redheads. Picture: istock

MOST fair-skinned redheads will know the pain of achieving a golden glow without harmful exposure to UV radiation or walking out of a salon looking like an oompa loompa.

But there still might be hope yet researchers in the US have successfully darkened human skin cells grown in a petri-dish, providing an artificial tan that lasted for days.

The Boston team have now tested the treatment on human skin and hope that it will one day be used with traditional sunscreens, potentially decreasing the incidence of skin cancer.

Researchers hope the drug will one day replace sunbeds. Picture: ThinkstockSource:ThinkStock

The drug, which is applied as a cream to the skin, generated a deep, cancer-protecting tan in red-haired mice. It worked by stimulating cells to produce more UV-absorbing pigments.

When applied to the red-haired mice, they could become almost jet black in a day or two with a strong enough dose, researchers observed.

The colour fades away over time as normal skin cells slough off the surface, and skin tone gets back to normal within a week or so.

Like pale-skinned redheads, red-haired mice are also extremely susceptible to skin cancer through UV radiation.

Scientists from Massachusetts General Hospital developed the new skin treatment using a class of small molecules.

The treatment of human breast skin explants with topical drug that induces pigmentation. Picture: Nisma Mujahid and David E. FisherSource:Supplied

David E. Fisher, dermatology chief at Massachusetts General Hospital and professor of Dermatology at Harvard Medical School, said it was difficult to get the drug to penetrate human skin as a result of having tougher skin than mice.

But ten years later, we have come up with a solution. Its a different class of compounds, that work by targeting a different enzyme that converges on the same pathway that leads to pigmentation, he said.

The research team is continuing to test the safety of small molecules in animals before carrying out toxicity studies in humans.

Read the original post:

New tanning drug darkens skin, could reduce incidence of skin-cancer – NEWS.com.au

Good news for redheads: a tanning drug for the pale-skinned – Medical Xpress

June 13, 2017

After 10 years of research, scientists have come up with a drug that could help people tan without exposure to the sun, potentially reducing the risk of skin cancer.

The drug stimulates cells that produce the pigment that absorbs ultra-violet light, the researchers said in the US journal Cell Reports published on Tuesday. They stressed that further tests are needed to safeguard against potential side-effects in humans.

Applied as a cream to the skin, the drug allowed red-haired mice to develop a deep tan. Like their pale-skinned human counterparts, the mice are particularly susceptible to the damaging effects of the sun’s ultra-violet rays.

The original breakthrough in mice was announced more than a decade ago, in a study published in the British journal Nature in 2006. But it has taken scientists that much time to work out how to make much thicker human skin absorb the substance.

The initial report revealed that a substance called forskolin gave red-haired mice a deep tan without exposure to UV light. But because human skin is relatively hairless compared to animals’, it has evolved to be much tougher in order to protect against heat, cold and other environmental factors, and the topical substance could not penetrate it effectively.

“Human skin is a very good barrier and is a formidable penetration challenge. Therefore, other topical approaches just did not work,” said David Fisher, chief of dermatology at Massachusetts General Hospital, a professor of dermatology at Harvard Medical School, and one of the authors of the study.

“But 10 years later, we have come up with a solution. It’s a different class of compounds, that work by targeting a different enzyme that converges on the same pathway that leads to pigmentation,” he said.

The scientists tested the substance on samples of human skin kept in laboratories and found that it darkened in proportion to the dosage applied. The tan lasted several days.

In animal tests, red-haired mice became “almost jet black in a day or two with a strong enough dose,” the researchers observed. When the dosage was removed, normal skin regeneration meant the color faded within a week or so.

“We believe the potential importance of this work is towards a novel strategy for skin cancer prevention,” Fisher said.

“Skin is the most common organ in our bodies to be afflicted with cancer, and the majority of cases are thought to be associated with UV radiation,” he said.

The long-term aim would be to create a cream that develops a tan without exposure to sunlight but which also absorbs harmful UV rays like traditional sun screens.

Explore further: Study replicates tanning response in cultured human skin

Journal reference: Cell Reports Nature

2017 AFP

Investigators at Massachusetts General Hospital (MGH) and Dana-Farber Cancer Institute (DFCI) have developed a way of increasing pigmentation in human skin without the damaging effects of ultraviolet (UV) radiation. Their …

A new study finds that carvedilol, a drug typically used to treat high blood pressure, can protect against the sun-induced cell damage that leads to skin cancer. Researchers serendipitously discovered the beta blocker’s cancer-fighting …

(HealthDay)Many Latinos think they’re safe from sun damage, even though advanced skin cancer is increasingly common in this group, a New York skin specialist warns.

Researchers at the University of Dundee have found that skin cancers in mice can closely mirror those found in humans, offering a model that could be used to help develop new drugs and find new ways of preventing the disease.

In 2006, UC researchers were given $1 million from the National Cancer Institute to develop a topical treatment that would not only make skin tan but would also work to both block harmful ultraviolet rays (UV) and repair …

A collaboration between Sad M. Sebti, Ph.D., chair of Moffitt Cancer Center’s Drug Discovery Department, and Michele Pagano, M.D., chair of the Department of Biochemistry and Molecular Pharmacology at New York University’s …

Today some patients suffering with mantle cell lymphoma, a type of blood cancer, can be treated with a pill called Ibrutinib, forgoing conventional chemotherapy. However, many are developing a resistance to this treatment. …

An international team of researchers bioengineering human liver tissues uncovered previously unknown networks of genetic-molecular crosstalk that control the organ’s developmental processes – greatly advancing efforts to …

Every day our bodies come under a barrage of toxic agents cigarette smoke, the sun, free radicals and other carcinogenic substances that create damaging lesions in our DNA that can initiate cancer and other human …

The human gene MLL is named for the mixed lineage leukemia it creates. Specifically, the gene may break apart and fuse with parts from one of a number of other genes on other chromosomes to create cancer-causing translocations. …

A Melbourne study is set to improve treatment options for patients with the second most common type of lung cancer, lung squamous cell carcinoma, a disease for which new anti-cancer drugs are urgently needed.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

See the original post here:

Good news for redheads: a tanning drug for the pale-skinned – Medical Xpress

Redheads Reunited At 3rd Annual Redhead Days – Patch.com


Patch.com
Redheads Reunited At 3rd Annual Redhead Days
Patch.com
HIGHWOOD, IL Extreme heat and high winds couldn't stop real redheads from coming out last weekend to gather for the 3rd annual Redhead Days Chicago festival in downtown Highwood. More than 2,000 reds and their friends gathered throughout the …

Read more from the original source:

Redheads Reunited At 3rd Annual Redhead Days – Patch.com

Community Voice: Red hair and the stereotypes that come with it – Kane County Chronicle

I can still hear the other fifth-grade student making fun of me for my hair color. I was always told by my mom and her friends that my red hair was beautiful and one of a kind. Most of my peers did not agree. Red hair is rare in the United States, making the color not only different, but also an opportunity for stereotyping.

Common stereotypes related to redheads include clownish, weird, unattractive, flaring temper, pale and Irish. These qualities are said to make finding a job and being in a relationship difficult for redheads. I found this interesting because companies should not be evaluating a candidates hair color, but instead their work ethic and passion. Stereotypes given to redheads are commonly negative. Not only does this affect their personal life, but their self-confidence as well.

Two scholars reported in the journal Symbolic Interaction: A fairly common pattern among redheads is that, as children, they receive much negative treatment from their peers. At the same time, they tend to receive many positive comments from adults, especially from elderly women.

Children can be cruel, and this allows for bullying toward redheads, lowering their self-confidence and continuing the stereotype.

As a redhead, I was able to experience this firsthand and relate well to this statement. Not until recently was I able to appreciate my red hair and how different the color is.

Red hair is not only a different color of hair, but also is a rare quality to have and can be linked to different medical concepts. For the future, I believe in a deeper investigation of the hair color. More should be tested and known about the diverse qualities given to redheads. I believe the public should stop using stereotypes as a way to judge redheads. While judging by schemes is a common problem in society currently, employers must not withhold a job from a citizen with red hair.

Hair color is a trait special to each individual on this planet, and while I think many people subconsciously note the color the red hair gene can offer a lot of information about the human body. I was frustrated when I did not find a lot of research on redheads response to pain just because I think that is an interesting topic to be involved with. For a person to have a such a rare hair color is special and adds interesting diversity to the world. When looking through a crowd of people, red hair stands out and is separate from every other hair color.

I found this topic to be widely intriguing and a subject that not many people have reported on. This topic offers new and interesting information for a researcher. Red hair is a color that will likely never go extinct the color will continue to be involved in the world and I look forward to the future when stereotypes will not hinder any redhead in his or her life.

Allison Hess is a student at Ball State University in Indiana and graduate of Batavia High School. She enjoys her family, friends and her red hair. Feedback on this piece can be sent to editorial@kcchronicle.com.

Visit link:

Community Voice: Red hair and the stereotypes that come with it – Kane County Chronicle

Redheads easily sunburned because of the mutation that gives them red hair – Genetic Literacy Project

[M]ost everyone regardless of hair color burns. Even people who never burn build up mutations in their skin when they tan; after all, tanning is the human bodys direct response to mutations triggered by ultraviolet radiation.

But redheads are in extra danger, thanks to a strange quirk of genetics.

One mutation in the gene that regulates pigmentation gives their hair that vivid color and sprinkles them with freckles, while also damaging their skins ability to protect itself from the suns harsh UV.

Sherrif Ibrahim, a dermatologist and skin cancer expert at the University of Rochester Medical Center, said that, thanks to that mutation, the cells in the skin of redheads do a bad job communicating with each other.

[R]edheads have a mutation to the gene that builds the melanocortin 1 receptor, or MC1R. When the genes in their skin start to mutate under a blast of UV radiation, their protective tanning response breaks down.

Those mutations build up until cells give up on surviving the brief flash of DNA damage and kill themselves to protect that damage from spreading throughout the body.

And thats what we call a sunburn.

The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion, and analysis. Read full, original post:A Single Mutation Is Responsible for Gingers Burning in the Sun

More:

Redheads easily sunburned because of the mutation that gives them red hair – Genetic Literacy Project

The Parson Red Heads Celebrate ‘Blurred Harmony’ Album Release With The Minus 5 in Portland (SHOW REVIEW … – Glide Magazine

On Thursday, June 8th Portlands Mississippi Studios played host to a local-centric bill from some of this citys finest acts. The occasion for such a gathering was the release of a new album, Blurred Harmony, from The Parson Redheads. Joining the venerable folk rockers were The Reverberations and The Minus 5.

Following an impressive opening set by local psych rockers The Reverberations complete with vintage Rickenbackers and plenty of pop-laden rock that sounded straight out of the 60s The Minus 5 took the stage. Wearing his trademark ball cap and raising a shot of tequila, Scott McCaugheycheerfully lead the band through one song after another while joking about how many in a row they could play and be able to nail a tight ending. Minus 5 member and sometime Portland resident Peter Buck did not make an appearance, but the audience hardly noticed as they bobbed their heads along to the bands playful garage rock. Much of the set focused on songs from the most recent release, Of Monkees and Men, a loving tribute to the Monkees where each song is about a member. McCaughey and co. delivered a set that was fun and rambunctious, offering up a jolly mood before the seriousness and focus of The Parson Red Heads.

This being an album release show, it was only natural that the band would want to show off their new material. That is exactly what they did, playing all of Side A, breaking with a few older tunes, and then playing all of Side B. Nobody in the audience seemed to have an issue with this as the album may be their strongest to date. The set kicked off with the soothing bass line of Come Save Me, a twangy power pop number that establishes the mostly mellow mood of the rest of the album. Coming Down a faster Paisley Pop tune reminiscent of The Creation came next and was quickly followed by the groovy infectiously harmonized Time After Time. Other highlights of the night included the cosmically twangified and Pink Floyd-esque Sunday Song, the soaring and catchy Time Is A Wheel, the riff-driven euphoria of Waiting For The Call, and the punchy upbeat rocker Out of Range.

As a whole, Blurred Harmony is one of the finest efforts yet from The Parson Red Heads. Its also a reminder that though they have a small following beyond Portland this band remains a hidden gem. Though the group is anchored by the soft-spoken vocals of front man Evan Way and his dynamic with wife and drummer Brette Marie Way, there is a communal spirit to the way this band sounds. At Mississippi Studios, this spirit was on full display as each band member seemed to be perfectly tuned in, focused not on standing out but rather playing an equal role in building the textural folk sounds within each song. The band seemed a bit nervous to be sharing the new album in front of an audience for the first time, yet their performance was flawless, as if they had been playing these songs for years.

All photos by Chad Lanning.

See the original post:

The Parson Red Heads Celebrate ‘Blurred Harmony’ Album Release With The Minus 5 in Portland (SHOW REVIEW … – Glide Magazine

Those Redheads From Seattle (Blu-ray) – DVD Talk

Billed just somewhat accurately as “the first 3-D musical” upon its 1953 release, Those Redheads From Seattle appears on 3D Blu-Ray as yet another title rescued from oblivion by the 3-D Film Archive. Set in 1898 during the Klondike Gold Rush, a “boomtown” called Dawson sprouts up in the Yukon territory with a casino called the Klondike Club being its social focal point. However there’s still plenty of moral high ground in the town who don’t approve of the gambling and burlesque shows going on there, and Vance Edmonds, a transplant from Seattle, often prints editorials about this in his newspaper. Someone at the club gets fed up with this and shoots him, hoping to put a stop to the paper altogether. Meanwhile back in Seattle, Vance’s wife (Agnes Moorehead) is keeping their home under control with their four daughters, the youngest of them, Nell (Kay Strother, half of the singing group the Bell Sisters) being blonde but the other three redheads and the title characters: Connie (Cynthia, the other Bell Sister), Kathie (Rhonda Fleming, who you can also see in 3D in Inferno) and Pat (Teresa Brewer), who aspires to be a professional singer the most although the entire family is musically talented, partly at the insistence of their mother. Mom is quite strict and traditional however, wanting the girls to sing hymns at their church and not any of that immoral up-beat stuff- in this era it was also considered quite risqu for a girl to show as much as her ankle onstage as well.

Before he’s shot, Vance mails a letter home saying that things are going OK for him but not great up north, so Mom decides for the whole family, including their pregnant cat, to make a surprise trip up to see him- not knowing that he’s been shot since news traveled slow in those days (no email or cell phones, you see.) On the way up they meet Joe (Guy Mitchell, who likely could have inspired Harry Connick Jr.’s look a few decades later) who is also headed to Dawson to sing and dance at the Klondike Club. The girls take a liking to him right away, but of course Mom has her reservations. Kathie also quickly falls for the club’s owner Johnny Kisco (Gene Barry), who knows who shot her father but isn’t quite sure if he should reveal this- at least until the girls suspect him of it. Before that comes to a head however the girls integrate into the town rather quickly. The whole family has to decide what to do with the newspaper after Vance’s death and stay there for a while, with Pat becoming a dancer at the club despite Mom’s severe disapproval.

Five songs are performed in the movie, but I wouldn’t quite call this a “musical” since my definition of that is when the cast breaks into song and dance spontaneously for the sake of the movie. Here all the songs are performed on stage or in other situations when they reasonably could have in the real world- for example the Bell Sisters sing “Take Back Your Gold” on the boat up north while playing a game that requires them to sing a song. There’s a couple of good stage numbers at the club as well, of course played to the audience there. While this might not seem like a movie that calls for 3-D, it’s used here in a way I haven’t quite seen in any other movie of the past or present. The effect is quite strong the instant the Paramount logo opens with the familiar mountain pushed far into the screen with the stars and lettering pushed outwards. Through the entire movie this sense of depth remains not quite as strongly, but as obvious to the picture as the colors. There’s a few well-placed 3-D gimmicks including characters subtly thrusting things they’re holding at the camera, and an amusing sequence where barrels filled with liquor are shot with the contents gushing out towards the audience before a herd of booze-happy mountain men crowd around to catch it. Unfortunately by the time this movie made it to theaters, the technical problems of 3-D at the time had given the technology a bad name and Paramount gave theaters the option to play it in plain old 2D. Reports of some of the 3D engagements were less than enthusiastic as well, mainly from the two film projectors refusing to stay in proper sync. The extras on this disc tell that story.

Shot with Paramount’s “Paravision” 3D camera rig, similar to the “Natural Vision” camera that shot many of the other famous 1950s 3D movies, the effect again is very immersive. If you’ve watched any of the more recent 3D movies and have failed to notice much of an effect, you’ll be in for a revelation here. In fact, this is another older movie that today’s filmmakers need to take a look at to see how 3D should be done. While the theatrical showings in 1953 might have had a few flaws, Bob Furmanek and company have seen to it that it looks as good here as it possibly can. They have pointed out that the biggest problem with this movie was the vertical alignment wasn’t consistent throughout the film prints, causing one eye’s view in some shots to appear higher up than the other. When a new film print of this movie was projected in Hollywood in 2006, the projectionist was said to have had to “ride” the framing knobs through the showing to keep them lined up- all of that has been done more precisely for this 3D Blu-Ray transfer.

This was also an early non-anamorphic widescreen film, shown in a 1.66 aspect ratio which is maintained on this disc. As for the quality of the picture itself, there’s a definite graniness throughout which is likely inherent in how it was shot. The color doesn’t quite “shine” the way you might expect, again partly from a likely intended look but also because of the shape the film elements were in. There’s no sign of excessive film wear however, and this is another case where when hearing the challenges of making this transfer you’ll be thankful for it looking as good as it does. The disc also includes a 2D viewing option which shows just the left eye’s view, sampling this it appears watchable but really takes away a big part of the picture.

In the “premiere” venues the sound was presented in discrete 3-channel stereo- the traditional stage channels but no surrounds. This was played off of a third machine in the projection booth from another reel of 35mm film with full magnetic coating- I got to see one of these in action at the Cinerama Theatre in Seattle. This of course also has to stay in perfect sync with the film projectors to work properly. The bad news is that like the WarnerPhonic track for House of Wax the multi-channel tracks for this movie have been lost, but the good news is that a fairly accurate re-creation was done from the existing elements. Encoded as a 3-channel DTS Master Audio Track, it’s a lively mix with most of the music isolated to the left and right (I went up close to the center speaker a few times and heard no music at all in that channel, similar to more recent digital mixes) with some dialogue and sound effects also venturing into the left and right. The levels of the left and right channels on this disc seem to be a bit higher than the center however, with music often drowning out dialogue. There’s also a transfer of the mono track available, in 2-channel DTS Master Audio that stays centered as it should.

A very informative commentary track accompanies the movie- most of it with Hillary Hess with 3-D Film Archive’s Bob Furmanek and Jack Theakston with Greg Kintz appearing in a separately-recorded portion around the middle of the film. While they talk a bit about the movie itself including the story and the actors, the main focus is on the technical aspects which of course delighted me and likely will anyone else interested in the history of 3-D filmmaking. They give plenty of time to the problems the 3-D presentation had, reading quotes from reviews of the first showings. I’d always found it a bit frustrating that the industry gave up on 3-D for so long after that, as it seems the problems with it were so notorious but I haven’t heard anything about what was done to fix them until digital projection came along decades later. The work done to restore the movie for this disc is discussed as well, with the statement “this was a really tough film to bring back to life” summing it up.

Separately there’s a 3D segment with Greg Kintz talking more about the restoration, showing before and after comparisons of a few shots showing the alignment problem as well as the faded color and general poor condition of parts of the film. A “Stereophonic Sound Demo” is kind of a waste of time, as it just re-plays Guy Mitchell’s “Chick-A-Boom” number inside a graphic of a theater screen with analog waveforms on the sides and above the picture- I would have liked to have seen how the mix was actually done instead. In 2D there’s an interview with star Rhonda Fleming at the 2006 Hollywood showing of the new film print, and the theatrical trailer is included (in 2D but flagged for 3D) from an analog video source with a lot of dot crawl and appearing to be stretched from 4×3. Amusingly it includes text saying the movie is actually in “4-D” with “4 Delightful singing stars”. A 1970s porn film called The Starlets later used the term “4-D” in its advertising, with the fourth dimension being something not suitable for family discussion.

Those Redheads From Seattle is yet another essential title for any 3-D enthusiast’s collection- that applies to just about everything the 3-D Film Archive has done so far, although A*P*E still has a few caveats being that it really isn’t a very good movie. Redheads however should appeal to anyone who appreciates a good classic.

Now if I may editorialize for a bit, I do need to point out that while 3-D Film Archive remains committed to restoring more vintage 3-D movies and putting them out on Blu-Ray, the fact remains that hardware support for home 3-D is alarmingly declining. None of the major TV manufacturers are including 3-D in any of their models for this year in the US (there are a handful of projectors that still include it), and this prompted me to buy an LG set with 3-D while it was still available when I hadn’t been planning on buying another TV for a few more years. While the 3-D on my previous Sharp TV was adequate, this LG blows that out of the water with not only a better picture but also much more affordable glasses- you can even use the same glasses you might have brought home from the theater with it. While the commentary on this disc discusses how 3-D movies came and went rather quickly in 1953 (it was likely recorded before this year’s announcement from the electronics manufacturers and thus that isn’t addressed), I think it’s safe to say there have been far fewer problems with home 3-D and it can only improve with each generation of displays- but only as long as the manufacturers continue to include it! Having 3-D disappear from home displays would be a huge mistake, rendering discs like this to not be viewable to their full potential and less likelihood for more to be released. I’d even argue that if not a single new 3-D Blu-Ray disc were released after this, the discs that have been put out from 3-D Film Archive plus the hundreds of other recent 3-D movies that have been issued are reason enough to keep including it on at least some displays on the market for a long time to come.

Jesse Skeen is a life-long obsessive media collector (with an unhealthy preoccupation with obsolete and failed formats) and former theater film projectionist. He enjoys watching movies and strives for presenting them perfectly, but lacks the talent to make his own.

What Do You Think?

Read more:

Those Redheads From Seattle (Blu-ray) – DVD Talk

King Black Acid, The Parson Red Heads, and LiquidLight at Doug Fir Lounge – Vortex Music Magazine

King Black Acid, The Parson Red Heads, and LiquidLight at Doug Fir Lounge
Vortex Music Magazine
After 13 years, the folk family are set to release their fourth LP via Fluff & Gravy on June 9 but they'll celebrate their cosmic Americana a day early at Mississippi Studios with The Minus 5 and… King Black Acid: 'Big Gummo – It's Cool To Be In Love

Read more from the original source:

King Black Acid, The Parson Red Heads, and LiquidLight at Doug Fir Lounge – Vortex Music Magazine

Redheads Unite For Annual Festival In Highwood – CBS Chicago

June 11, 2017 6:12 PM

CHICAGO (CBS) Gingers ruled this weekend in Highwood, as the north suburb hosted its 3rd annual Redhead Days.

Both days you could see Gingers in hula hoops. There were contests galore, including a contest to determine the reddest dog and another for the best carrot cake.

Music was provided in part by the Redhead Lounge. They decided who had the longest red beard, and hair; and there were symposiums both days with Buzzfeeds Erin LaRosa, who has authored The Big Redhead Book.

Peter Jackson made the trip solo from Wllmington, Delaware, and said being a redhead is somewhat like belonging to an exclusive club.

Were pretty much a rare breed, he said. Were sporadic in a crowd. Its not every day you see a big crowd of redhaeds together in one place.

What do they talk about together?

Our beautiful hair, of course. We talk about how its neat to be different, he said.

Jackson claimed gingers are more sensitive to heat and cold changes; and he claimed it takes 20 percent more anesthetic to knock one out.

CBS 2

WBBM Newsradio 780 & 105.9FM

670 The Score

Connect

Mobile

Advertise With Us

Contest & Promotion Rules

About Us

Advertise

Ad Choices

Business Development

Contact

Only CBS

CBS Radio Jobs

CBS Television Jobs

EEO Reports

CBS Television Public File

CBS Radio Public File

See the article here:

Redheads Unite For Annual Festival In Highwood – CBS Chicago

This Week in Forsyth County History: June 11-17 – Forsyth County News Online

June 12, 2008

Since at least 2008, plans for Lanier Golf Course have been in the works, though it wasnt until earlier this year that the current Board of Commissioners finally approved the courses development.

June 14, 1987

Water parks are a summer staple every child loves. Though many things have changed in the last 30 years, the concept of traveling down a long slide in a tube has not.

June 11, 1999

Forsyth County currently contracts with Central EMS for its ambulance services. Eighteen years ago, the county used Advance Ambulance Inc., though a May review of the service was highly critical.

June 16, 2011

Two men were charged with illegally cutting down a tree and leaving it in the middle of Hwy. 20 on June 2. According to this story, they dragged it along the highway before abandoning it in the middle of the busy road.

June 12, 2004

Riverwatch Middle and Shiloh Point Elementary schools, while now staples in the county, were only built just over a decade ago. Two new high schools are currently being built.

June 13, 1940

More than 75 years ago, Forsyth Countys first theater, the Frances Theatre, and only showed good, clean, wholesome and educational pictures. The theater cost $7,500 and was named for the youngest daughter of Mayor Roy Otwell.

June 17, 1965

Brenda Hubbard of Chestatee High School signed a contract in 1965 to play with the professional All-American Red Heads, a professional womens team based in Caraway, Arkansas. The team played across the U.S., Mexico and Canada and was billed as the world championship girls professional team.

June 11, 1970

There must have been more room in the county in 1970. That year, the federal census found the county had a population of 16,436, up more than 4,000 from 1960. In 2016, the countys population was estimated at 221,009.

June 17, 1965

In 1965, readers were given a history of the countys namesake, John Forsyth. Forsyth was the 33rd governor of Georgia also served in the U.S. House and Senate and was Secretary of State from 1834-1841 under Presidents Andrew Jackson and Martin Van Buren.

June 16, 1977

Forsyth County is now home to many restaurants and other stores selling alcohol, but none of that may have been possible without a referendum in 1977 for voters to decide whether alcohol sales should be allowed in the county, which was approved by commissioners after a long and controversial discussion.

More:

This Week in Forsyth County History: June 11-17 – Forsyth County News Online

A Single Mutation Is Responsible For Gingers Burning in the Sun – Inverse

Summers coming which means red heads everywhere are cringing at the prospect of their skin frying from the sun.

Sure, most everyone regardless of hair color burns. Even people who never burn build up mutations in their skin when they tan; after all, tanning is the human bodys direct response to mutations triggered by ultraviolet radiation.

But redheads are in extra danger, thanks to a strange quirk of genetics.

One mutation in the gene that regulates pigmentation gives their hair that vivid color and sprinkles them with freckles, while also damaging their skins ability to protect itself from the suns harsh UV.

Sherrif Ibrahim, a dermatologist and skin cancer expert at the University of Rochester Medical Center, said that, thanks to that mutation, the cells in the skin of redheads do a bad job communicating with each other.

Heres how that communication mess-up occurs: Everyone has two main types of cells in their skin: keratinocytes and melanocytes. Most of the cells are keratinocytes, which have little in the way of natural defenses against UV. They rely on melanocytes, which dump a protective pigment melanin into their neighbors when their neighbors call for help: Were mutating! Were mutating!

In most folks, that process works pretty well, Ibrahim said.

Imagine the finger of the melanocyte extends and knocks on the door of the keratinocyte, he said. The keratinocyte has to open up a hole in its membrane to let the melanin in. It knows to do that thanks to a very specific [signal] receptor called the melanocortin 1 receptor.

But redheads have a mutation to the gene that builds the melanocortin 1 receptor, or MC1R. When the genes in their skin start to mutate under a blast of UV radiation, their protective tanning response breaks down.

Those mutations build up until cells give up on surviving the brief flash of DNA damage and kill themselves to protect that damage from spreading throughout the body.

And thats what we call a sunburn.

But sunburns arent very effective at scouring your body of mutated cells. Some damaged DNA survives which is a big reason why redheads, who only account for one or two percent of the population, account for a full 16 percent of melanoma. Slather up!

Read the rest here:

A Single Mutation Is Responsible For Gingers Burning in the Sun – Inverse


12345...102030...