Genelex Enables Genetic Risk Analysis and Precision Medicine in EHRs and Population Health Software with New APIs

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Genelex Enables Genetic Risk Analysis and Precision Medicine in EHRs and Population Health Software with New APIs

TGen scientists discover the likely cause of rare type of muscle weakness in six children

Scientists at the Translational Genomics Research Institute (TGen), using state-of-the-art genetic technology, have discovered the likely cause of a child’s rare type of severe muscle weakness. The child was one of six cases in which TGen sequenced — or decoded — the genes of patients with Neuromuscular Disease (NMD) and was then able to identify the genetic source, or likely genetic source, of each child’s symptoms, according to a study published April 8 in the journal Molecular Genetics & Genomic Medicine. Continue reading



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TGen scientists discover the likely cause of rare type of muscle weakness in six children

UK biotech Silence Therapeutics raises $58 million for its RNA drive

Home Mail Search News Sports Finance Weather Games Answers Screen Flickr Mobile More Politics Celebrity Movies Music TV Groups Health Style Beauty Food Parenting Makers Tech Shopping Travel Autos Homes Try Yahoo News on Firefox Skip to Navigation Skip to Main content Skip to Right rail Sign In Mail Help Account Info Help Suggestions Continue reading



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UK biotech Silence Therapeutics raises $58 million for its RNA drive

Silence Therapeutics raises 38 million pounds for its RNA drive

Home Mail Search News Sports Finance Weather Games Answers Screen Flickr Mobile More Politics Celebrity Movies Music TV Groups Health Style Beauty Food Parenting Makers Tech Shopping Travel Autos Homes Try Yahoo Finance on Firefox Skip to Navigation Skip to Main content Skip to Right rail Sign In Mail Help Account Info Help Suggestions Continue reading



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Silence Therapeutics raises 38 million pounds for its RNA drive

It Takes Two To Tango: Combine Diagnostics And Drugs For Precision Medicine

Personalization is the New Name of the Game Precision medicine, also known as personalized medicine, is a concept of combining a drug with a test that is modified to a persons genetic disposition. The test has the ability to predict disease risk, diagnose disease and monitor therapeutic response. Continue reading



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It Takes Two To Tango: Combine Diagnostics And Drugs For Precision Medicine

Study identifies genetic variants linked to Hirschsprungs disease

Rare disorder can spring from common mutations that affect nerve development Genetic studies in humans, zebrafish and mice have revealed how two different types of genetic variations team up to cause a rare condition called Hirschsprungs disease. The findings add to an increasingly clear picture of how flaws in early nerve development lead to poor colon function, which must often be surgically corrected Continue reading



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Study identifies genetic variants linked to Hirschsprungs disease

New genetic clues emerge on origin of Hirschsprung's disease

Genetic studies in humans, zebrafish and mice have revealed how two different types of genetic variations team up to cause a rare condition called Hirschsprung’s disease. The findings add to an increasingly clear picture of how flaws in early nerve development lead to poor colon function, which must often be surgically corrected. The study also provides a window into normal nerve development and the genes that direct it. Continue reading



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New genetic clues emerge on origin of Hirschsprung's disease

Researchers produce iPSC model to better understand genetic lung/liver disease

(Boston)–Using patient-derived stem cells known as induced pluripotent stem cells (iPSC) to study the genetic lung/liver disease called alpha-1 antitrypsin (AAT) deficiency, researchers have for the first time created a disease signature that may help explain how abnormal protein leads to liver disease. The study, which appears in Stem Cell Reports, also found that liver cells derived from AAT deficient iPSCs are more sensitive to drugs that cause liver toxicity than liver cells derived from normal iPSCs Continue reading



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Researchers produce iPSC model to better understand genetic lung/liver disease

Cancer's relentless evolution

All living things–from dandelions to reindeer–evolve over time. Cancer cells are no exception, and are subject to the two overarching mechanisms described by Charles Darwin: chance mutation and natural selection. In new research, Carlo Maley, PhD., and his colleagues describe compulsive evolution and dramatic genetic diversity in cells belonging to one of the most treatment-resistant and lethal forms of blood cancer: acute myeloid leukemia (AML) Continue reading



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Cancer's relentless evolution

iPSC model helps to better understand genetic lung/liver disease

Using patient-derived stem cells known as induced pluripotent stem cells (iPSC) to study the genetic lung/liver disease called alpha-1 antitrypsin (AAT) deficiency, researchers have for the first time created a disease signature that may help explain how abnormal protein leads to liver disease. Continue reading



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iPSC model helps to better understand genetic lung/liver disease

Some false postive prenatal genetic screens due to mother's extra DNA segments

People differ in the size and composition of their chromosomes, which can affect the test results IMAGE:This is conceptual art of maternal blood screening of fetal DNA. view more Credit: Alice C Gray Prenatal blood screening for extra or missing chromosomes in the fetus might give false-positive results if the mother’s genome contains more than the usual number of certain DNA segments. This finding is reported April 1 in the New England Journal of Medicine Continue reading



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Some false postive prenatal genetic screens due to mother's extra DNA segments