Ireland Portrush

Sorry folks having such a good time we haven't kept up to date but will do so over the next day or so.The boys felt very guilty at not stopping for us to do some shopping at Galway when we left Sligo so we stood our ground and we did serious RT and the boys took off to the Royal Sligo Golf Course to have a look at a true links course. All was achieved with RT and the boys were happy too.Headin

First four days in japan

Sooo today is my first day in the apartment where I am staying with Xander in Miyazaki after an entire day of traveling here. Spent about 4 hours on the bullet train fastest in the world 3 hours on the bus then a 10 minute car ride to get here from Tokyo. Day 1 The first thing you notice when you get to japan is how hot it is... You get sweaty just from walking around Tokyo which is

Underwater Tomb

After leaving Jeju Island I returned to Busan where I stayed for five days or so just relaxing and enjoying the beach. From there I went to Gyeongju where I had a reservation at a hostel. When I showed up to the hostel they said that it was all full. I felt like Seinfeld trying to talk to this guy. He told me that if I wanted I could upgrade for 10 to another room. I told him that I wasn't going

Last Day and Hope for No More Owwies

Scrambling to pack and I have two meetings with our agency guide today so have to get over to the island both times. Allen will stay here with the boys. Yesterday was great quietish breakfast a first with no screaming only moderate mess. Coming back from dinner Bao stuck his hand in the elevator door and Allen had to literally push the door back to get it out. It made the elevator inoperable

Chengdu A city you won’t leave once you come

Chengdu is endowed with plentiful natural resources and sites of historic interest. The city of Chengdu is home to China's living treasures the Giant Panda as well as many other endangered species. With a history of over 2400 years it is home to many amazing historical sites and archaeological wonders and Chengdu's local cuisine is world renowned for its delicious spiciness. The life pace in Ch

Dominion Creek

We started the day by calling Jodie to wish her a happy birthday Then we drove out to ldquothe creeksrdquo. The road was built at the top of the hills because at the bottom were the gold claims and also there was soft muskeg and other roadbuilding problems. We came to a park sign explaining roadhouses. It seems that a roadhouse was built almost every mile in the area providing food and s

Mount Isa Day19

Today we stayed around Mt Isa in recovery mode after the long trip yesterday. The weather was clear but windy. It warmed up during the afternoon. This is very much a mining town the mines produce lead copper tin silver and gold. We walked up to Observation Hill along Rodeo Drive had lunch in a coffee shop had the windscreen fixed and then visited the Underground Hospital. This hospi

Roadtrip East Coast 2010

Hallo iedereen met veel goede zin publiceren wij onze blog genspireerd van onze avonturen uit Australi het is nogal een lap tekst geworden dus smeer nog even een broodje of zet koffie. Voor diegene die zich zelf met zijn hoofd op het toetsenbord vindt dat vinden wij niet erg zolang er maar een berichtje achter gelaten wordt. Veel plezier en de groeten van Jan Elise Roel AnkaZo'n vier ma

Trip to Mount Isa Day 18

We arose early as we were leaving Tennant Creek to begin our long journey across the Great Artesian Basin to Mt Isa. The day was clear and cool and sun strike was the early problem. As we left town we were almost wiped out by a road train turning across our bow. This was really scary we came up to the lights and we had the right of way green light. Luckily Graham noticed this huge road train co

Moving into a flat

Well I've had some ups and downs since i've moved to Australia. Leahanne and her roomie Karen were so awesome for letting me stay with them as long as I did but it was time to move on. I found a backpacker apartment to move into in the same area as Leahanne. It's an agency that has a couple of apartments and rents them out to backpackers and puts small groups and singles together. So I went to c

Mongol Vs Conductor

Mongol Vs Conductor We had taken our seats and were waiting for the bus to fill when the old Mongolian got on. Every craggy feature on his wizened old face had a story to tell none more so than the large cleft in his left ear. Aimless incoherent mutterings fell from his toothless mouth. Here was a character who had many a battle behind him. Bent double he slowly lurched down the bus before li

To go or not to Go

So about a month ago i was sitting at work and thinking man i just came back from Cuba 2 months ago and i have to already get out of here. I asked my boyfriend if we can go on another trip he said it's too soon and too much money. So i started thinking why not go by myself. How did i come to the decision to go to Thailand Well i was looking at tours a group of people like myself to jo

17th to 18th of August 2010

Woke up on Tuesday for a tour of Quebec city. Skipped breakfast as we had too much food the night beforeThe citedal is beautiful and worth a visit. It is a Unesco world heretage site.The local guide was excellent and she had a voice that could possibly shatter glass at 50 paces.After the tour we had time to explore. The department store Simons and the railway hotel and roman catholic church.An e

Anniversary Week

This week is my school's anniversary which means that there's a lot of activities happening every day. During every recess the school hosts some kind of competition where grades get points and the winner earns the ultimate prize which I still don't know what it is. So far I've seen sports dance and games competitions among other crazy things. So you can believe me when I say that there is abs

Day 63 August 17 2010 Wells NV to Salt Lake City UT

Beautiful sunny 92 degree day in Wells NV. Decided to have the motorhome washed. Looking for fuel filter for motorhome hope to find in Salt Lake City. We crosssed 6967 elevation in Nevada. Message center displayed message of Reduced Engine Power and motorhome would not exceed 400 rpms. Pulled off after a few minutes message went away and engine seemed to run fine. Continued down the roa

Day 62 August 16 2010 La Grande to Wells NV

Morning started early could not sleep. Up at 6am. After talking with Workhorse Service Center in Marietta GA head to WalMart to get air filter. Took wrong exit and wound up on gravel road with no space to turn entire rig around so we dropped the LilTruk and turned around. Aleta followed me back to WalMart we get the air filter and Aleta had a good laugh when my belt buckly kept getting

Beer, Women and Psoriasis: Bad Brew? – CBS News


Indian Express
Beer, Women and Psoriasis: Bad Brew?
CBS News
New research from Brigham and Women's Hospital and Harvard Medical School in Boston indicates that drinking beer can increase the risk of psoriasis by more ...
New study suggests connection between drinking beer and psoriasis in womenPitch Weekly (blog)
Women with psoriasis risk: Say no to beerUPI.com
Beer Linked To Women Psoriasis IncreasesRight Pundits
ADAN News (blog) -NHS Choices -Chicago Sun-Times
all 157 news articles »

Testosterone: Not an Anti-Aging Panacea

On the car radio, I have several times happened upon “infomercial” programs touting the benefits of testosterone replacement therapy for men, broadcast by doctors who specialize in prescribing the drugs. They have lots of wonderful stories about men who feel younger, happier, and more vigorous because of their macho remedies. It’s a tribute to the power of the placebo.

I have been reviewing John Brinkley’s goat gland scam for a presentation on medical frauds. In an era before the isolation of the hormone testosterone, Brinkley transplanted goat testes into human scrotums in an attempt to treat impotence and aging. We are more sophisticated today … but not much. Longevity clinics and individual practitioners are offering testosterone to men as a general pick-me-up and anti-aging treatment. Their practice is not supported by the scientific evidence.

Men’s testosterone levels drop as they age. According to a review article in the New England Journal of Medicine

the decrease in testosterone in men occurs moderately and gradually over a period of several decades. The serum total testosterone concentration decreases from a mean of about 600 ng per deciliter (20.8 nmol per liter) at 30 years of age to a mean of about 400 ng per deciliter (13.9 nmol per liter) at 80 years, although the range is wide at all ages. In one study, approximately 20 percent of men older than 60 years of age had total serum testosterone concentrations that were below the normal range for young men.
An essential but still unanswered question is whether this decrease in the testosterone concentration is physiologic, perhaps conveying a benefit, or pathologic, causing harm.

Other things happen as men age, and a simplistic, hopeful approach is to blame many of the consequences of aging on decreased testosterone levels and to use replacement therapy to bring the levels back to those of healthy youth. That approach is not science-based. Science only supports raising testosterone levels in patients who have specific problems attributable to abnormally low levels.

A recent article in JournalWatch reviewed the subject with reference to three new studies.

A July 2010 article in the NEJM by Wu et al. found that the only symptoms that correlate to low testosterone levels are poor morning erection, low sexual desire, and erectile dysfunction. Other psychological and physical symptoms correlated poorly with low testosterone levels. Total testosterone levels were sufficient for diagnosis; free testosterone levels did not add to diagnostic accuracy.

An article in the Journal of Clinical Endocrinology and Metabolism by Krasnoff et al.  found that total testosterone was not associated with mobility limitation, subjective health, or any physical performance measures, whereas free testosterone was associated with subjective health and some (but not all) physical performance measures. Low baseline free testosterone levels were associated with subsequent decline in mobility but not in subjective health. JournalWatch editor Dr. Alan Brett comments that this study

shows correlations between free testosterone and some measures of physical performance; however, findings were mixed, and significant associations in observational studies do not necessarily indicate cause-and-effect.

 

A third study by Basaria et al. published in the New England Journal of Medicine  studied older men with limitations of mobility to see if testosterone supplementation would improve mobility by increasing muscle mass and strength. This trial was stopped early because of a higher rate of cardiovascular events in the testosterone group compared to the placebo group.

The JournalWatch editor comments:

These studies — considered alongside other recent studies in which testosterone supplementation did not yield impressive results in frail older men or in healthy older men — argue against indiscriminate use of testosterone as an “anti-aging” drug. This conclusion is supported by a new practice guideline from the Endocrine Society.

Testosterone is not harmless. The Mayo Clinic website lists several adverse effects of testosterone: sleep apnea, elevated red blood cell count, heart disease, acne, benign prostatic hypertrophy, breast enlargement, reduced sperm production, and shrinkage of testicles. Mentioning a risk of testicular shrinkage in the infomercials would put quite a dent in sales, I imagine.

Meanwhile, Suzanne Somers recommends testosterone for everyone: both men and women. On the Oprah website, readers provide testimonials:

Just ask my husband who take [sic] testosterone daily thanks to Suzanne’s books.

The unsupported opinions of celebrities and longevity opportunists versus the evidence of science-based medicine: take your pick.


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Dr. Gorski to be speaking at the Chicago Skeptics on Saturday

The week is finally here! Believe it or not, I’m heading back to my old stomping grounds in the 1990s to appear as a guest of the Chicago Skeptics.

This Saturday, August 21, I’ll be giving a talk co-sponsored by Chicago Skeptics, Women Thinking Free Foundation, and the Center For Inquiry-Chicago at the Black Rock Pub & Kitchen. My talk will be on a topic near and dear to my heart (or a topic that fills me with alarm–the two are not mutually exclusive), mainly the infiltration of pseudoscience into medicine. I’ll be sure to touch on a number of issues, and you can be sure I’ll have something to say about the recent acupuncture review that appeared in the New England Journal of Medicine and perhaps a bit about the sort of pseudoscience that’s being practiced at some of our largest and most respected cancer centers. Afterwards, you–yes, you!–can ask me about anything you want if you show up. Anything, including vaccines, skepticism, and even Bill Maher!

If you live in Chicago and want to harass me (not the way Age of Autism harasses me), head on over to the Chicago Skeptics event page and click on the link to RSVP!

ADDENDUM: Holy crap! Someone just informed me that Chicago Comic Con will be in Chicago the same weekend as me. Even worse, William Shatner will be there on Saturday, which is when I’m giving my talk. How on earth can I possibly compete with the Shat?


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