People’s Lifespans May Increase In the Future. Why Do They Desire Longer Lives? – The Swaddle

People are fascinated by the extremes of humanity, whether its going to the moon, how fast someone can run in the Olympics, or even how long someone can live,says Michael Pearce from the University of Washington (UW) in the U.S., who recently led a study that estimates with almost a 100% probability that the present record for maximum reported age at death 122 years, 164 days will be broken by 2100.

And with a continuous expansion in the world population, the likelihood of breaking records is only rising, the researchers believe.

Published in Demographic Research, their study assessed the extremes of human life by studying longevity records of more than a thousand people from 13 countries across the world, as well as of almost 14,000 individuals, who died between the ages of 105 and 109. Using statistical modeling to analyze the data, the researchers found that a lifespan of 125 years, or even 130 years, is possible in his century.

Basically, the researchers based their findings on two factors: how the risk of dying flattens after age 110, and growth in the number of people to reach age 110 this century, according to an article in The Conversation by Pierce and his co-author on the study, Adrian Raftery, who is a professor of statistics at UW.

Related on The Swaddle:

Graying of Hair Due to Stress May Be Reversible, New Study Finds?

On the one hand, life expectancy is on the rise globally due to advances in healthcare, and due to these same advancements, the researchers believe there is a flattening of the mortality rate after people reach a certain age someone who hits 110 has the almost same probability of living another year as someone reaches the age of 114.

This is a very select group of very robust people, Raftery explained, adding that if theyve gotten past all the various things life throws at you, such as disease, [then] they die for reasons that are somewhat independent of what affects younger people.

However, it may be pertinent to note, here, that the study is based on data gathered before the pandemic hit, and claimed more than 43 lakh lives globally. And, in any case, as the researchers clarified, the maximum is not the average, and just because we may break records by the end of the century, doesnt mean everyone or even most people will live to be 110.

A study from June had found that while we may live longer now, we cant really slow the process of aging in any manner. Our findings support the theory that, rather than slowing down death, more people are living much longer due to a reduction in mortality at younger ages, Jos Manuel Aburto, one of the studys co-authors from the Oxford University, had told The Guardian.

Yet another study from May had found that even if a person manages to avoid dying of heart disease, cancer, or road accidents, the human bodys structural and metabolic systems do fail beyond a point that lies between 120 to 150 years; making 150 years the absolute longest a human being can live.

Related on The Swaddle:

Scientists Say Gut Microbes May Reverse Aging Process in Human Brains

But so many studies on the subject of human lifespans beg the question: what drives our desire to live longer especially at a juncture when climate change is expected to make life difficult in myriad ways?

Experts believe it could be because we dont understand death. So the prospect of not living triggers a kind of FOMO. The quest to live forever, or to live for great expanses of time, has always been part of the human spirit The most difficult and inscrutable thing to us as mortal beings is our own death We dont understand it, we dont get it, and as meaning-laden beings, we cant fathom what it means to not exist, Paul Root Wolpe, an American sociologist and bioethicist, told Time.

As for people like Teslas Elon Musk and Googles co-founder Sergey Brindriving researchin increasing longevity to the point of, perhaps, being immortal, ego may be an important factor. Obviously they believe the world cant possibly survive without their existence, and so they think their immortality is so critical to the survival of the world, Ezekiel Emanuel, an oncologist and bioethicist, said.

Wolpe, however, notes that younger people have a harder time [dealing with the idea of dying] compared to older people. My youngest is upset that I do not want to be frozen and woken up in the future, Suzanne Moore, a columnist for The Guardian wrote last year.

According to Wolpe, older people dont care about living as long as younger people do because living longer doesnt make aging slower just as the study from June proved. What you see when you actually look at people at the end of life, to a large degree, is a sense of a life well-lived and a time for that life to transition itself, he notes.

Read more:
People's Lifespans May Increase In the Future. Why Do They Desire Longer Lives? - The Swaddle

Elevian Targets Aging to Solve Humanity’s Toughest Diseases – BioSpace

Mark Allen, CEO of Elevian, pictured above. Photo courtesy of Elevian.

Once the domain of mythical fountains of youth and movies like The Curious Case of Benjamin Button, the science of aging prevention and reversal is beginning to enter the mainstream with reputable academic institutions launching companies to accomplish this once improbable feat.

One such company,Elevian, founded by a team of Harvard scientists and physician-turned entrepreneurDr. Mark Allen, is working to restore regenerative capacity with the aim of preventing and treating age-related diseases. A critical factor, they say, is a single protein called Growth differentiation factor 11 (GDF11).

Allen, Elevians chief executive officer, first became interested in the science of aging after taking a course focused on exponential thinking.

All of a sudden, problems that were heretofore unsolvable become solvable, Allen said of the theory that is the opposite of incremental and encourages one to think outside of the box. They talked about examples of problems that weve always thought to be unsolvable, one of them being aging and longevity. So that was it for me. I was like thats perfect for me. Thats what I want to work on.

Searching for clues into the diseases associated with aging, Elevians founders, including Harvard professor of Stem Cell and Regenerative BiologyDr. Amy Wagers, mined the proteome, looking into how proteins change with age. They uncovered several, including one with potentially groundbreaking regenerative capabilities, GDF11.

Elevian believes that this single protein, a key player in the circulatory system, could be a game-changer in regenerative medicine.

GDF11 is one of those proteins that change with age, Allen said.They [the founders] really dug into GDF11 because so little was known about it at the time of their discoveries. They did side-by-side studies with the parabiosis model, injecting just GDF11, to see if it could reproduce some of the effects of parabiosis in the aged animal. And they found, much to everybodys surprise, that replenishing just this one circulating factor was able to reproduce many of the beneficial effects of parabiosis.

Parabiosis, which means living beside, is performed by joining two living organisms surgically to develop a single, shared physiology. It has been used to study conjoined twins, and more recently, in a 1972 lifespanstudyattaching old and young rats, scientists Frederic C. Ludwig and Robert M. Elashoff showed evidence of an extended lifespan for the older animals.

As a post-doc at Stanford, Dr. Wagers expanded upon this research using modern histology techniques. When Wagers and her colleagues attached the circulatory systems of young mice to old ones, they found strong evidence of a biological reversal of many characteristics of aging. Later, Dr Wagers and colleagues discovered that injecting only GDF11 in aged animals can reproduce many of the benefits of parabiosis, in apaperpublished in Science in 2014 and recognized as arunner-upto the publications Breakthrough of the Year.

What they found is that the old animals exposed to young blood experienced a biological reversal of aging by many different measures. Their brains grow younger, their hearts grow younger, their lungs, their bones all over their body. And interestingly, the young animals exposed to old blood have accelerated aging. So this is just really strong proof that circulating factors regulate aging, said Allen.

The mechanism of action appears to be that GDF11 binds directly to endothelial progenitor cells that line our blood vessels and improves both the quality and quantity of the vasculature. It does not cross the blood-brain barrier, so we think its mechanism is primarily by improving vasculature, he explained.

Elevian, the recent beneficiary of an initial round ofseed financing,is actioning this potent protein to develop a potential regenerative treatment for stroke patients.

English biomedical gerontologistAubrey de Grey, whom Allen credits with doing a lot to start the medical field of aging reversal, outlined several hallmarks of aging in his 2007 book, Ending Aging. These include stem cell exhaustion, protein aggregate buildup, failed intercellular communication, and senescent cells.

One of the barriers to developing therapeutics based on these factors is the inherent incongruence with the usual regulatory approval systems. Following customary protocol, proving that a drug prevents aging or age-related diseases would quite literally take a lifetime.

Theres no regulatory path for treating aging. Even doing a prevention trial would take years and years and years, because you have to take people and wait until they get disease to see effects. So instead, to get a drug to market, we take the opposite extreme. We look at what is the most devastating possible disease, unmet need, where we could treat for the shortest possible duration and see clinically meaningful effects, Allen explained.

Elevian decided on stroke, which is thenumber two causeof death worldwide and the third leading cause of disability.

The only existing treatments for a stroke are limited to the acute phase, where an IV injection of a drug such as recombinant tissue plasminogen activator (tPA) (Activase)restores blood flow by dissolving the clot causing the event.

In an ischemic stroke, which makes up87%of cases, a blood clot forms and prevents blood and oxygen from reaching an area of the brain, impacting breathing and heart function and often leading to paralysis. This is where Elevian believes a drug utilizing GDF11, which acts on the circulatory system, holds such promise for rehabilitation.

Allen revealed that his team has already demonstrated GDF11s impact on stroke-stricken animals.

When we give GDF11 to animals that have had strokes and are paralyzed or have severe motor function debilitation, it returns them almost to normal function. It significantly improves motor function recovery, he said.

On the strength of these preclinical results, Elevian is gearing up to enter human clinical trials with GDF11 for the treatment of stroke.

We really got the green light to go into humans based upon the animal data that we got there, Allen said, adding that there is still a lot of work to be done before they reach this phase. We still have to scale up production of the drug and we have to do extensive safety and toxicology tests IND-enabling studies. The longest pole in the tent is figuring out how to make manufacturing costs effective. The cost of goods is going to be really, really high. So were doing a lot of work in process development right now, and then were going to hand it off to a manufacturing partner to scale up. Were about two years from initiating our human clinical trial in stroke.

Another unmet need where Elevian believes GDF11 can have an impact is Type 2 diabetes, a disorder whose pathology is also intricately connected to the circulatory system and often to aging.

Along with blood clotting factors, glucose resides within the inside lining of blood vessels. InType 2 diabetics, the lining of an individuals blood vessels begins to become glycosylated, which causes them to narrow, impeding blood flow. Glucose tolerance is known to decrease with age.

In a study published in March 2020, Wagers and her colleagues stated that GDF11 was shown to significantly improve glucose tolerance in aged mice and increase glucose homeostasis, under a variety of dietary conditions.

Allen believes that addressing the aging process is the ultimate exponential strategy to solving a whole host of humanitys biggest killers:

This idea that we could, by targeting the aging progress, potentially promote healthy aging, promote a healthy longevity, and reduce the burden of age-related diseases, and that the same treatment could be used to treat and prevent multiple age-related diseases. That concept was like, why arent we working on that? Why are we spending billions of dollars on Alzheimers and billions of dollars on cancer, billions of dollars on heart disease? We could instead target the aging process and potentially treat them all.

Most Read Today

Read more:
Elevian Targets Aging to Solve Humanity's Toughest Diseases - BioSpace

When will COVID travel safety improve? 5 experts weigh in – Los Angeles Times

How do you measure the risks of pandemic travel, and when will the time be right to go again?

We asked five infectious disease experts, including one who hadnt left home in four days, one who has taken two Mexican vacations since March and one who recently awakened from a COVID/Disneyland nightmare.

The first thing we must do, they agreed, is stay close to home for at least several more months, get vaccinated, and watch virus transmission and ICU numbers closely. Putting down the pandemic in California and elsewhere, they said, will depend on how faithfully we use masks, keep our distance and wash our hands habits that will remain vital as authorities strive to vaccinate 300 million or more Americans by summer.

I will never get on an airplane again without a mask, said Dr. Kimberly Shriner, an infectious disease specialist at Huntington Hospital in Pasadena.

Now is not the time to be traveling. For leisure or business, said Dr. Luis Ostrosky, a professor of infectious diseases at McGovern Medical School at UTHealth in Houston.

If you fly now, said Dr. Krutika Kuppalli in Charleston, S.C., you can almost guarantee that there are going to be people on the airplane with you who have COVID.

These experts all are wary of new variants of the virus. None is flying now. Three have spent recent months within 120 miles of their home, as authorities urge all Californians to do. (That advisory remains in place, despite Gov. Gavin Newsoms loosening of many restrictions on Jan. 25.) But their perspectives vary.

Ostrosky, born in Mexico City, has a lot of family there. So when his grandmother died recently, he thought about making the trip south. Mexico is one of the few countries Americans can visit without a mandated quarantine.

Newsletter

Get inspired to get away.

Explore California, the West and beyond with the weekly Escapes newsletter.

Enter Email Address

Sign Me Up

You may occasionally receive promotional content from the Los Angeles Times.

But he didnt go because of the pandemic. After much talk, he stayed put in the U.S. Before he resumes travel, he said, hell ask several questions.

Whats the positivity rate? I would avoid traveling to any place that has a positivity rate over 5%, he said. Above that, you dramatically increase your chances of exposure. Californias seven-day average positivity rate the number of COVID tests that yield positive results was 12.4% on Jan. 27.

How full and how capable are the hospitals? Scores of U.S. hospitals are at surge capacity, with shortages of ICU beds. Because most county governments report COVID information daily, Ostrosky said, its actually pretty easy to find data. As for capability, any hospital with a Level 1 trauma center (the most comprehensive trauma care) would satisfy him, Ostrosky said. The American College of Surgeons maintains a database.

Does this destination require testing to enter or leave? Many travelers might hope for that, but I just dont want to get stuck somewhere, Ostrosky said. People can test positive for a long period of time without being infectious.

This is now a factor in any flight to the U.S., including returning round-trip flights. As of Jan. 26, the U.S. Centers for Disease Control requires all air travelers to show a recent negative COVID test result before they can board any flight heading to the U.S.

Shriner, who also is a tropical disease specialist and director of the Pasadena Travel Medicine clinic, has been vacationing in Europe for years and has spent more than 20 years making regular visits to a medical project in Tanzania.

But at Huntington Hospital, ever since the holidays, were just absolutely getting hammered with cases of people who traveled, she said.

Outside the hospital, Shriner has done some driving around California, but hasnt flown since March. Like her colleagues, she believes that driving (especially if you bring food and avoid public toilets) is safer than flying and much safer than cruise ships (most of which are idle now).

Like Ostrosky, she wants to see a positivity rate of 5% or less at her departure point and at her destination. For data, she recommends the Johns Hopkins University Coronavirus Resource Center.

Shriner likes the idea of airlines and destinations requiring negative test results or vaccination. Whether or not those are required, Shriner said, people should get vaccinated, wait at least four weeks (to allow resistance to strengthen), and consider their age and immunity history before making travel plans.

In darker moments, she said, she worries that this could just go on for another year or two if people dont widely accept the vaccine. She also shared a recent nightmare: She was on the Pirates of the Caribbean ride at Disneyland (which remains closed) surrounded by unmasked strangers.

On the brighter side, shes hopeful that travel might be safe as soon as late summer or early fall. But it is all dependent on human behavior, Shriner said, and we know how unreliable that is!

Kuppalli moved in August from the San Francisco Bay Area to Charleston, where she is an assistant professor in the division of infectious diseases at the Medical University of South Carolina. She grew up in the Bay Area and had planned to visit her parents there this month.

Then the numbers surged. I decided not to travel, she said in mid-January. I havent left my house in the last four days.

To assess risk, you cant look at one particular piece of information, she said. You have to look at the entire thing. ... I totally get that this is hard for everybody. But this is not the time to travel. We all need to be thinking not just about ourselves, but everybody.

Before Dr. Nancy Binkin became a professor at the Wertheim School of Public Health and Human Longevity Science at UC San Diego, she lived for 12 years in Italy, doing epidemiology training for the Italian National Institute of Health.

So when that countrys fatalities soared in the early weeks of the pandemic, followed by escalating U.S. numbers, it put fear into me, Binkin said. I have not been out of San Diego County since March.

One pandemic number she watches closely is the adjusted case rate. That count measures the seven-day average of daily new cases per 100,000 people (jails and prisons excluded). Any number above seven per 100,000 puts a county in the states most dangerous category, the purple tier. On Jan. 27, Californias statewide rate was 71.6 per 100,000. Before she travels, Binkin wants to see that number below seven.

When it comes to flying, she worries about jet cabins and tiny bathrooms, but perhaps even more, she worries about the lines of people and gathering points at airports, she said.

Newsletter

Get The Wild newsletter.

The essential weekly guide to enjoying the outdoors in Southern California. Insider tips on the best of our beaches, trails, parks, deserts, forests and mountains.

Enter Email Address

Sign Me Up

You may occasionally receive promotional content from the Los Angeles Times.

Would I feel comfortable going down to Mexico? No, she said. I wouldnt.

Dr. W. David Hardy, former director of Cedars-Sinai Medical Centers infectious diseases division and adjunct clinical professor at USCs Keck School of Medicine, has mixed feelings.

Hes angry about rampant disregard for science and inconsistent messaging under the Trump administration. But Hardy sees great hope in the vaccines.

When he was treating HIV patients during the grimmest years of the 1980s, Hardy recalled, there was no such cause for encouragement.

To have a vaccine [that prevents] 90-95% of people from getting sick is amazing, Hardy said. He suggests that the vaccines are going to be the final answer, especially if the vaccines thwart transmission of the virus as well as block symptoms.

Yet the metrics for measuring transmission are ever changeable, and it may be difficult planning travel based on those, he said. They are going to be fluctuating for a while. I would say from six months to a year.

Since March, Hardy said, he has scrubbed trips to Europe, North Africa and Hawaii. But in September, after Californias first surge had passed, Hardy and his partner flew to Los Cabos, in Baja California, for a vacation. It went well. So in December Hardy and his partner flew again, this time to Cancn and Playa del Carmen on Mexicos east coast, where they found the local people there were using masks religiously.

The other visitors? Not so much.

I would say 50-60% of the tourists were completely ignoring the mask requirements.

Most of them were Americans, Hardy said, and he began asking people to put on their masks or if they had no mask, to step away from where I was standing.

The whole experience was confusing and disconcerting, he said. When I got home from my second trip to Mexico, I turned to my partner and said, This is not a good time to travel. People are not adhering to what they should be adhering to.

In some respects, Hardy said, that behavior reminds him of the 1980s when HIV was new. Then as now, he said, until one of your friends, family or work associates dies of this disease, you still look at it as a sort of distant thing that doesnt affect you.

Link:
When will COVID travel safety improve? 5 experts weigh in - Los Angeles Times

Oh! How the stay at the top has changed Comrade Museveni – The East African

By TEE NGUGI

I was amazed to hear Yoweri Museveni lamenting about foreign interference in the internal affairs of Uganda. These fellows, he said, in reference to foreign news networks in particular and the West in general, have a primitive culture that allows interference in other peoples affairs. He intimated that African culture would never allow him to interfere in other peoples business.

Now, this was exactly the sentiment voiced by African leaders in the 1980s when they were faced with agitation for a return to democracy. They castigated news networks and the West for trying to impose a foreign ideology on otherwise peace-loving Africans. Democracy, they said, was a system alien to African culture, because it was adversarial while African traditional democracy was consentaneous. They dismissed those calling for democracy as foreign stooges.

Human rights originations, such as Amnesty International, were accused of trying to bring about a re-colonisation of Africa.

When Museveni took power in 1986, he represented a new kind of leadership. He brought stability to a country ravaged by murderous chaos for decades. He revived an economy ruined by corrupt regimes, beginning with Milton Obotes in the 1960s. In the rest of Africa, his progressive ideas were a beacon of hope on a continent in the vicious grip of tyranny and consequent poverty. He supported progressive forces in Kigali when the rest of Africa looked the other way. Likewise, he gave support to forces attempting to overthrow Mobutu Sese Sekos rapacious dictatorship.

Kenyan dissidents, facing death or jail, found safe passage through Uganda. He memorably called the Organisation of African Unity, the predecessor body to the African Union, a trade union of dictators. He advocated for a new Africa where leaders served the people, not their stomachs. He did not object when the West and human rights organisations, which he now criticises for interfering in the internal affairs of Africa, praised the new breed of African leadership he represented.

But oh, how years at the top change everything! Critics and oppositions members like Bibi Wine are regularly arrested. Elections are accompanied by intimidation and violence.

In the region, Museveni is a defender of the old order. He is now an ardent supporter of the AU which, like its predecessor body, looks the other way as leaders terrorise and impoverish their citizens, but is quick to condemn ill-treatment of African-Americans in America. Museveni, who once said that the problem of Africa was leaders not wanting to leave power, now says that longevity in power has made him an expert in governance.

Now, if he Museveni were a Lee Kuan Yew, the man who presided over Singapores spectacular rise, perhaps his longevity in power could be justified. But like last weeks column argued, his continuation in power is detrimental to the economic and social welfare of Uganda in particular and Africa in general. Who would have thought back then that Museveni, like Mugabe, would transform from liberator to oppressor.

Tee Ngugi is a Nairobi-based political commentator

View original post here:
Oh! How the stay at the top has changed Comrade Museveni - The East African

Is this Scotland’s oldest cat? | HeraldScotland – HeraldScotland

HE may not be quite as old as his cartoon namesake but at the grand old age of 26, Snoopy could well be Scotland's oldest cat.

The hardy rescue moggy, who has clawed his way up the equivalent of 120 human years, was discovered abandoned and 'near feral' in the gutter and was the runt of the litter, according to his owner.

However, the six-week-old kitten thrived under the care of his new family and even overcame cat flu - which can often be fatal in felines.

The average lifespan for a domestic cat in the UK is 14 with animals described as geriatric if they survive beyond 15.

Snoopy may be frail but apart from losing his hearing he has no other health problems and is now enjoying the high life with the odd potter around the garden and regular helpings of his favourite meal of mince and tatties.

READ MORE: Donations pour in after death of wildcat kitten Huntleigh

His owner Lorraine Leskovec, 57, says she's amazed by his longevity - he's survived three other, younger cats.

"I've always felt that when I've lost other cats that they have left a bit of themselves in Snoopy," she said.

"He's a good old boy. As far as I remember, I had been looking for a kitten for a wee while and phoning the cat and dog home because at that time they were hard to get.

"They phoned me one morning to say they had a litter of kittens in. So we went down and there was a wee one that kept hiding in the corner and he was the runt of the litter and I thought that's the one I'm having.

READ MORE: Huntleighthe rescued wildcat kitten passes away

"He used go outside a lot but now it's just now and again. In the Summer he loves to finda sunny spot but not in this cold weather, he's too frail now.

"When he was younger he was quite robust, he was quitethe cat of the town," added Snoopy's owner, who lives in Carnwath, near Lanark andhas another Ragdoll cat called Rocky, who is blind.

"His appetite has gone through the roof but I think that is part of being an older cat. At the moment he will eat everything from mince and tatties to cheese. He gets what he wants now."

Cats may not really have nine lives, but factors such as diet, healthcare and environment can have an impact on how long they live.

Older catsgenerally succumb to illnesses such as kidney disease, arthritis, congestive heart failure, liver disorders, and renal disease.

READ MORE: Cat missing for 12 years re-homed after living as a stray on the shores of Loch Lomond

The oldest cat ever, according to the record books was called Creme Puff. It was born on 3 August, 1967, and lived for 38 years and three days.

"I would never have thought he would have lived to this age, " said Ms Leskovec, who works for Tesco.

"He's an amazing cat. Every day I say to my partner, 'IsSnoopy still breathing?' I'm hoping he will just slip away when the time comes."

See the original post:
Is this Scotland's oldest cat? | HeraldScotland - HeraldScotland

Racism has a physical impact on the body — here’s how – The Conversation CA

I began to write this essay in January 2020, what feels like years ago. The issues I wanted to raise are no longer even partly hidden. The effects of racism on the body, especially the black body, are in plain sight.

Most of these problems have been there for centuries, but are now called pandemics. Pandemics of murder, of disease and of social inequality. In the face of new waves of deaths, including those that precipitated the Black Lives Matter movement, the world is reawakening to the power of racism to kill people.

The Effects of Race Project at the Stellenbosch Institute for Advanced Study started in 2013. The goal of a team of academics was to better understand the everydayness of race and how race-thinking created durable and seemingly inescapable racialised realities in South Africa, the US and elsewhere.

Race thinking the idea that people belong to a race determined mostly by their skin colour has so framed our realities that we can scarcely imagine a world without it.

But race thinking has deformed us and society because its based on constructs of otherness and difference. These, in turn, underpin expectations of character, intelligence, motivation and behaviour. They can pave the way for the unleashing of suspicion, derogation and dehumanisation.

Racism affects health and often leads to early death. We now know in greater and more disturbing detail how this occurs. It kills directly and abruptly when people are murdered by police or vigilantes, but it also kills through disease. COVID-19 is new, but diseases common to the survival zones of the urban poor have been with us for a long time. It was only a century ago that the bone disease rickets was so common among African American children of eastern US cities that it was considered a rite of passage.

More sinister even are the health problems caused by acute and chronic stress on people who are subjected to racial othering and overt racial discrimination. The trauma of humiliation caused by racism creates recurrent stress in individuals, families and wider communities. These stresses manifest in manifold ways, and often transcend generations.

Racism has been described by sociologist Gran Therborn as an existential inequality that diminishes or denies agency and personhood. But racism is also a vital inequality in his classification because it shapes the human life course by determining life expectancy and overall health and well-being.

Racism operates at multiple levels to negatively affect health. Physical violence and rampant infectious diseases are the tip of the iceberg. Institutional racism negatively affects access to health services and healthy lifestyle choices by creating neighbourhoods or districts where people cannot thrive.

And when members of stigmatised racial populations respond to the pervasive negative racial stereotypes by accepting as true the dominant societys beliefs about their biological and cultural inferiority, they can internalise the racism. Internalised racism manifests itself in many ways. It leads to lower self-esteem and psychological well-being.

When people are worried, day in and day out, about their safety, their future, and how they are being perceived by others because of racism, they experience stress and anxiety from recurrent humiliation. These effects are not transient, nor merely psychological.

Its been known for years that the psychological stress attendant with racism has, for example, a significant effect on the development and progression of atherosclerosis, a precursor to serious heart disease. This outcome arose from a lifetime of experience.

But the full weight of psychological and physical damage caused by the chronic stress of racism is only now beginning to be fully understood.

The social context in which a child lives is a powerful predictor of their adult health. It can also affect their genes, in ways that are only now being recognised.

One of the most disturbing set of discoveries in the field of epigenetics is stress can affect the way an individuals genes work, and that some of the stress-related changes can be inherited.

Epigenetics is the study of changes caused by modification of how genes work rather than by altering the genetic code itself. Epigenesis is the transmission of information to new cells during cell division that determines how genes are expressed which genes present are turned on and which are silenced.

Read more: How the dimensions of human inequality affect who and what we are

Studies of epigenetic changes can illustrate the specific biological mechanisms by which social conditions become physically embodied. What we are now understanding is how feedback loops are established by early life stressors causing negative emotions which cause biochemical and physiological changes. These in turn cause changes in behaviour that alter the chemical environment in which genes are being expressed.

The chain of events from genetic modification to behaviour is long and there is no predetermined conclusion, but the mere fact that this can happen is profoundly disturbing. That some of the genetic changes may be inherited is even more so.

When we grasp the reality that human bodies and genes are being constantly remodelled by the physical and social environment and by life experience, the inescapable conclusion is that we must fight the origins of health disparity at their root, in the early social environment and life experiences of every person.

Its incumbent on all governments to recognise the seriousness of epigenetic influences on human well-being, especially in early life. Findings such as these should be used to promote widespread social reforms that fight the larger geographic, sociocultural, economic and political contexts in which health disparities are embedded.

Read more: We need to unpack the word 'race' and find new language

In short, the development of a healthy citizenry depends on people growing up with adequate nutrition, protected from violence, gross insecurity and humiliation, and raised in environments conducive to the development of emotional security. We have known for a long time that poverty, poor nutrition, child abuse, trauma and fear were bad for health.

What epigenetic research offers is the shedding of light on the biological pathways through which such exposures are translated into concrete, measurable, increased risks of various diseases such as bipolar disease, asthma, adverse birth outcomes and the now widely recognised problem of decreased longevity.

Understanding how genes are differentially regulated by experience will affect how we conceptualise social inequalities and health disparities.

Rather than engaging in outdated nature vs nurture debates concerning race as a genetic or social construct, considering race as an epigenomic construct may be the most accurate and appropriate perspective yet.

The real world is the one in which we understand genes and the socially experienced world as perpetually entwined in the human body.

This article is part of a series that has been running for seven months. Other authors include Barney Pityana, Gran Therborn, Njabulo Ndebele, George Chaplin, Kira Erwin and Kathryn Pillay.

The three edited volumes of essays published by African Sun Media in 2018 (The Effects of Race, edited by Nina G. Jablonski and Gerhard Mar), 2019 (Race in Education, edited by Gerhard Mar), and 2020 (Persistence of Race, edited by Nina G. Jablonski) contain the complete representation of the projects scholarship.

Here is the original post:
Racism has a physical impact on the body -- here's how - The Conversation CA

Letter to the editor: Lowry’s take on climate wrong – Bryan County News

Editor:

Im writing in response to Rich Lowrys December 31 opinion piece on the climate crisis.

His premise is that climate change does not pose an existential threat to humanity and that its preposterous for President Elect Biden to make that claim. His reasoning requires that we equate existential threat with the threat of human extinction. Then he outlines what in fact are the existential threats of climate change as the reasons why humans wont go extinct. When sea level rises, we move inland. When temperatures continue to rise, we deploy more air conditioning. When droughts persist, use less water. Theres really nothing to worry about. Humancleverness will save the day.

He then shifts gears. There really isnt anything bad happening now. The world has been getting warmer for decades (currently 2 degrees F above the 1895 2015 average) with no adverse effects on human population or longevity. Here he dismisses all the unprecedented wild fires, hurricanes producing hundred year rain totals, and record droughts and floods by criticizing the President Elect for claiming that they are caused by climate change. We all know the difference between climate and weather and have heard the scientists insist that any given weather event cant be directly attributed to climate change. But I invite everyone to step back and look at the totality of weather related disastersover the past 5 years and draw your own conclusions.

Even Mr. Lowry concedesThere is no doubt thathuman activity contributesto climate change. So,what is Mr. Lowrys plan while the world puts 32.5 billion metric tons of CO2 into the atmosphere annually (US share 5.1 billion) and the average global temperature rises 1/20 degree F per year? ...seek to understand better and prepare to address through adaptation and innovation should the worst come decades from now. And whats President Elect Biden proposing? According to Mr. Lowry to suspend all rational thought-especially the downsides of costly measures to crimp the US economy in the name ofsaving the planetMr. Lowry doesnt saywhat these costly measures are. Here are a few: encourage sustainable energy alternatives, revamp the electrical grid, require more energy efficient buildings, institute more sustainable agricultural practices, encourage the move to electric vehicles, make conventional vehicles more efficient, maybe start planting trees like mad. The list is endless. The article claims we are an innovative species.

Do we follow Mr. Lowrys advice and sit and contemplate our navels while digging up the Canadian wilderness to get at the tar sands, etc etc i.e. business as usual, or do we start doing what we know must be done and what President Elect Biden is proposing.

Jim DeFelice, Richmond Hill

The Bryan County News welcomes letters to the editor. Letters cannot be libelous, must be factual and should be brief, typically 250 words or less. Letters may be edited for length, accuracy and clarity, and are limited to two letters per writer per month. No unsigned letters will be printed. Contact information, including the writers address and telephone number must be submitted with letters. We make no guarantee your letter will be published, though we will make every effort to print those meeting our guidelines. Send letters to editor@bryancountynews.com.

Link:
Letter to the editor: Lowry's take on climate wrong - Bryan County News

What are longevity supplements, and are they safe? – MarketWatch

Aches and pains. A growing waistline. Diminishing eyesight, hearing loss, memory lapses. These are the woes of growing older for some people, once considered inevitable. But recent, exciting discoveries in the fast-growing field of longevity science have some doctors and researchers pronouncing that these symptoms of aging may one day be treatable with pharmaceuticals, gene therapies or other yet-to-be-discovered medical technologies.

Many people havent been content to wait, though. Dozens of commercial producers are selling hundreds of so-called longevity supplements right now, and sales data suggest anawful lot of peopleare trying them. But do they work? Are they even safe?

To find out, we scoured the latest research and interviewed two top scientists in the field. What we learned suggests that you may want to hold off on ordering a supply, or at least do your research very carefully.

There is a solid handful of compounds that look very promising in the scientific quest to slow the aging process. One of the most exciting is nicotinamide adenine dinucleotide, or NAD, which has been shown to extend both the lifespans and youthful function of yeast and animals in clinical trials. Human trials are ongoing, with only a handful published to date.

NAD (also often written as NAD+) is a substance found in every cell in your body, which controls all kinds of metabolic processes, including the regulation of sirtuins, the so-called longevity genes. As you age, your NAD+ levels decline, and scientists think it is perhapsthisdecline that leads toall sortsof other age-related declines.

Also read: Should you invest in the new longevity funds?

The working theory, then, is that if we can boost our NAD+ levels as we age, we can slow our decline tremendously. Lab studies on yeast and rodentslend strong supportto that theory. The most recent studies have primarily involved the administration of either nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), which is then converted into NAD in the body.

To learn more about NAD, Next Avenue talked to Dr. Shin-Ichiro Imai, professor of developmental biology at the Washington University School of Medicine in St. Louis. Along with Leonard Guarente, Imai discovered the link between NAD and sirtuin control in 1999. Hes been studying the molecule ever since.

There have been 10 human clinical trials using NR, most at very high dose, with no safety issues, Imai said. Most of those trials, however, lasted for a duration of weeks or months at most.

Is it safe to take NAD-boosting supplements continuously, for years?

NMN and NR have already been available in Japan and the U.S. since 2015, and some people have been taking it since then, Imai noted. Anecdotally, I havent heard of any side effects from the taking of these supplements.

Some trials, however, have recorded mild side effects including headaches, nausea, diarrhea and skin flushing.

See: 3 aging experts tell how they decided on where to grow older

More troubling, however, is the conclusion of a 2019 study that showed a possible link between elevated levels of NAD and tumor growth in isolated cells and animals. Rugang Zhang, deputy director at the nonprofit Wistar Institute Cancer Center in Philadelphia, was the lead researcher on that study.The study, published in the UK journal Nature Cell Biology, did not find that NAD causes cancer, rather that elevated levelsappeared to accelerateoncogenesis (tumor formation) already in motion.

We dont want to oversell the results of our study, Zhang said. Lots of studies in the literature have clearly demonstrated that as normal cells age, there is lower NAD. So, supplementing NAD could be beneficial. Its possible that NAD boosters could help people live longer and healthier. Were not saying that if people take NAD boosters they will get cancer. This was a very early study on mouse models, and more study is needed.

He suggests a course of action grounded in a deep preponderance of evidence: At the end of the day, we just need more knowledge, through more research. We need the scientific community to come to a consensus. The risk to potential benefit remains to be seen.

Mucking up the risk/benefit ratio further is the fact that supplements are onlyvery lightly regulatedby the U.S. Food and Drug Administration, with the testing, evaluation and labeling of such products left up to manufacturers. This presents another dilemma for those considering longevity supplements: theres no sure way of knowing exactly what youre getting.

The results of the few published human clinical trials to date unequivocally show that taking NR boosts levels of NAD in the body. But apparently, more NAD doesnt translate to more youthful function.

See: There are six types of retirees which are you?

Unfortunately, those studies have not yet shown any significant efficacy, Imai said.

And thats when the substance administered is of lab-grade purity. So what about the typical supplements available online?

There are so many products out there, Imai lamented, particularly for NMN, but Im concerned about the quality.

Indeed, a 2020meta-analysisof NAD trials surmised: it seems likely that side effects linked to interventions that target NAD metabolism more likely arise from impurities rather than the supplements themselves, since this industry generally operates without rigorous control of quality and standardization.

Imais lab has evaluated a number of commercially available NAD-boosting supplements, but found only two of lab-grade purity. Imai wouldnt disclose the names of the products (both Japanese-made), as he doesnt endorse supplements. But he did note that they are extremely expensive.

Dont miss: What is the secret to aging well?

Finally, we asked someone whod taken an NAD-booster to share her experience. Kim Oberdorfer, an air-traffic controller in Oakland, Calif., wasnt impressed.

I took [a popular NR supplement] for about two months and it just gave me these dull headaches. I was having hot flashes last February, and when I told my sister Im 47, shes 53 about how horrified I was to be having them so young, she goes, Are you sure its not just a reaction to an NAD supplement? said Oberdorfer. At the time I wasnt really working out much, but my sleep schedule was really messed up and I heard it was good for that as well. I didnt think it helped at all.

Rashelle Brownis a longtime fitness professional and freelance writer with hundreds of bylines in print and online. She is a regular contributor for NextAvenue and the Active Network, and is the author of Reboot Your Body: Unlocking the Genetic Secrets to Permanent Weight Loss (Turner Publishing). Connect with her on Twitter and Instagram @RashelleBrownMN.

This article is reprinted by permission fromNextAvenue.org, 2021 Twin Cities Public Television, Inc. All rights reserved.

More from Next Avenue:

Here is the original post:
What are longevity supplements, and are they safe? - MarketWatch

LyGenesis Receives FDA Clearance to Begin Phase 2a Trial of its Cell Therapy for Patients with End Stage Liver Disease, and also Closes $11 Million…

PITTSBURGH, Dec. 30, 2020 /PRNewswire/ --LyGenesis, Inc., a biotechnology company developing cell therapies that enable organ regeneration, announced today that the U.S Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) application.Under the IND, LyGenesis will be conducting a Phase 2a study on the safety, tolerability, and efficacy of its first-in-class novel cell therapy for patients with end stage liver disease (ESLD).

In addition, LyGenesis just completed over $11 million in private financing of convertible notes led by Juvenescence, Ltd. and Longevity Vision Fund. Proceeds will be used to fund LyGenesis's Phase 2a clinical trial with a first patient in targeted for early 2021, as well as to push forward on their other cell therapies using lymph nodes as bioreactors to regrow functioning organs, including pancreas, kidney, and thymus regeneration.

"The FDA clearance for our IND and the start of our Phase 2a study in patients with ESLD is a testimony to our robust preclinical research program, the unmet need in advanced liver disease, and our novel approach to organ regeneration. Moreover, the lack of genetic manipulation, ease of administration, and low cost of goods for our cell therapy forms the foundation for a promising and scalable first commercial product," said Michael Hufford, PhD, Co-Founder and CEO of LyGenesis.

"LyGenesis's progress has been simply extraordinary. They have recently published 4 peer-reviewed papers on their regenerative medicine technology, filed and received clearance for their first IND, identified a primary site for their Phase 2a clinical trial, and now have closed a round of financing to ensure they have the cash to run their trial and also progress additional cell therapies toward the clinic," said Jim Mellon, Co-Founder of Juvenescence, and Chair of LyGenesis's Board of Directors. Sergey Young, founder of Longevity Vision Fund, said "We are excited to support LyGenesis in its vision to tackle some of the most challenging unmet medical needs of our time with a unique organ regeneration technology. By enabling one donated organ to act as a source of therapies for dozens of patients, LyGenesis is on the cusp of disrupting the supply-demand calculus of organ donation, and this regulatory clearance from the FDA is a definitive milestone in their evolution."

About LyGenesis, Inc.LyGenesis is a biotechnology company with an organ regeneration technology platform enabling a patient's lymph nodes to be used as bioreactors to regrow functioning ectopic organs. LyGenesis's lead allogeneic cell therapy program is focused on liver regeneration for patients with end stage liver disease. Its drug development pipeline includes thymus, pancreas, and kidney regeneration. Privately held, LyGenesis is headquartered in Pittsburgh, Pennsylvania. To learn more, please visit lygenesis.com.

About Juvenescence, Ltd.Juvenescence Ltd. is a life sciences company developing therapies to modify aging increasing human health span and longevity. It was founded byJim Mellon,Dr. Gregory BaileyandDr. Declan Doogan. The Juvenescence team are highly experienced drug developers, entrepreneurs and investors with a significant history of success in the pharmaceutical and consumer health sectors. Juvenescence will create, partner with or invest in new companies with longevity-related therapeutics, by in-licensing compounds from academia and industry, or forming joint ventures to develop therapeutics for longevity. Juvenescence believes that recent advances in science have greatly improved our understanding of the biology of aging and seeks to develop therapeutics with the possibility of slowing, halting or potentially reversing elements of aging. To learn more, please visit juvlabs.com.

About Longevity Vision FundLongevity Vision Fund is a venture capital fund that invests in technologies with the potential to disrupt life sciences to help people live longer and healthier lives. The fund is focused on early diagnostics, AI in healthcare, and advanced therapeutic platforms targeting aging and age-related diseases. It was founded by Sergey Young, a venture capital investor with a mission to make longevity more accessible and affordable. Sergey is also an Innovation Board member at XPRIZE Foundation and a development sponsor of Age Reversal XPRIZE. To learn more, please visit lvf.vc.

Contact InformationMichael Hufford(858) 603-2514[emailprotected]

SOURCE LyGenesis, Inc.

Read the original post:
LyGenesis Receives FDA Clearance to Begin Phase 2a Trial of its Cell Therapy for Patients with End Stage Liver Disease, and also Closes $11 Million...

Pleasant Hope facility looking to hire people to work in beef processing plant – KOLR – OzarksFirst.com

PLEASANT HOPE, Mo. A beef processing plant in the process of being built in Pleasant Hope, Missouri, is looking to hire job seekers to work in its 100,000 square foot facility.

Pam Johnson, the director of human resources, said she is working with Missouri Prime Beef Packers to figure out what kind of employees it wants working in its facility.

Here we focus on doing the right thing: for the employee, the animal, the consumer, Johnson says. We are going to take care of our team members. The owners and management team have fully embraced the show me culture, and they want to show current and potential team members that they will be taken care of. We are offering great pay and benefits as well as continued encouragement to improve and learn new skills. As people strive to grow, they will be rewarded.

The plant will have the capacity to process up to 500 cows per day, but director of operations Mike Schmeling said their focus is more on quality.

We are not a big plant that is solely focused on the number of head processed per hour, said Schmeling. We are flexible. We can respond to market changes, consumer demands, or other unexpected factors like COVID-19 as well as, if not better than, anyone in the industry.

Nick Paschkov, COO of Missouri Prime Beef Packers, hopes for the plant to positively impact the community.

The ownership has shown their commitment to the longevity and success of this plant by empowering us to use our experience to design a state-of-the-art beef processing plant that will be a model for future facilities, Paschkov states. This company emphasizes food and employee safety and product quality over volume production, and our design accounts for that.

The construction phase of the plant is underway to process both fed and non-fed beef cattle. Missouri Prime Beef said its searching for people who can supply cows and buy products along with those seeking employment.

Those interested can look at Missouri Prime Beefs website or call 417-462-6727.

Originally posted here:
Pleasant Hope facility looking to hire people to work in beef processing plant - KOLR - OzarksFirst.com

Leading Healthy Aging Researcher Brian Kennedy, Ph.D., To Address Natural Health Industry On Impact Of Nutrition On Biological Age – PRNewswire

FERNANDINA BEACH, Fla., Dec. 9, 2020 /PRNewswire/ -- Ponce De Leon Health, Inc. ("Ponce de Leon"), a longevity research company focused on the reversal of epigenetic aging, announced today that Brian Kennedy, Ph.D., will speak at the SupplySide Network "Healthy Aging Never Gets Old" event on December 10th, 2020, at 1:00 PM Eastern.Doctor Kennedy is currently serving as Director of the Centre for Healthy Longevity, at the National University of Singapore.Registration for this free event can be found on theSupplySide Network 365platform.

Doctor Kennedy was invited to address industry leaders to discuss recent research which led to the development of Rejuvant LifeTabs, a dietary supplement designed for healthier aging. Informa Health & Nutrition named Rejuvant LifeTabs asthe top Consumer Packaged Goods winner in the Best Life-Span Specificcategory, at the 2020 NEXTY SupplySide Awards. According to Informa, Rejuvant contains "a ground-breaking ingredientLifeAKGand a meticulously researched, time-release formula tailored to men and women."

This news follows on the heels of Ponce De Leon Health announcement in September with the first peer-reviewed study of a non-drug substance demonstrating improvements in mammalian lifespan, reduction in frailty, and reduction in time of suffering. The results of the research were published in the September 1, 2020 issue of the journal Cell Metabolism. The researchers found that LifeAKG "promotes longer, healthier life associated with a decrease in levels of inflammatory cytokines. Strikingly, the reduction in frailty led the scientists to "propose that Ca-AKG compresses the period of morbidity." The publication, titled "Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice," and was authored by Azar Shamirzadi, Ph.D., et al., and directly led to the development of Rejuvant LifeTabs.

Tom Weldon, the CEO and Founder of Ponce De Leon Health, remarked, "We're very proud of our research, past and ongoing, and committed to reversing epigenetic aging. Our product, Rejuvant LifeTabs, is emblematic of the growing discoveries in the field of epigenetics, or the changes made by modification of gene expression.We continue to conduct new human and animal trials to better demonstrate the benefits of Rejuvant on biological aging, healthspan and lifespan."

Todd Runestad, Senior Editor of Ingredients and Supplements, New Hope Media and Natural Products Insider, invited Dr. Kennedy to speak at the event.Said Mr. Runestad, "healthy aging is a prime consideration of supplement usersfrom specific health conditions like bone or joint or cognitive health, to the more general concept of aging gracefully. Of course, people have long sought out skin-health products, but the new frontier is the provocative research around epigenetics and nutrigenomicsthat one's lifespan is not just predicated on genetics, but that gene expression can be modulated by diet and specific dietary supplements."

Mr. Runestad added, "Brian Kennedy has been researching such concepts for decades now. He is one of the world's leading anti-aging researchers, and he may have come up with this decade's resveratrolthe fountain of youth molecule found in red wine. We awarded a NEXTY award for the year's best innovation, integrity and inspiration, to a supplement brand Dr. Kennedy helped develop for Ponce de Leon Health. The company's Rejuvant LifeTabs, coupled with an in-home genetic test kit, allows consumers the ability to actually track over time genetic markers of aging while taking the supplement. Personalized health care meets anti-aging science."

About Ponce De Leon HealthPonce De Leon Health (www.PDLHealth.com) is a commercial-stage longevity company focused on the discovery, development and commercialization of non-prescription consumer products to address the reversal of epigenetic aging. Their goal is to increase human healthspan, improve quality of life, and reduce the cost of providing late stage health care to customers.

To learn more about the groundbreaking science behind Rejuvant LifeTabsvisit http://www.rejuvant.com or follow @rejuvanthealth(Facebook), @Rejuvant (Twitter), or Ponce De Leon Health (YouTube).

SOURCE Ponce De Leon Health

http://pdlhealth.com

Go here to see the original:
Leading Healthy Aging Researcher Brian Kennedy, Ph.D., To Address Natural Health Industry On Impact Of Nutrition On Biological Age - PRNewswire

Fasting to Enhance Longevity? – L.A. Weekly

During the holidays, fasting may be the furthest thing from your mind. Once the Holidays are over, however, it may suddenly seem like an attractive option. Eating, as a basic activity of daily living, compensates for feelings of hunger and provides necessary nutrients to our physiological systems. Moreover, what we eat and how we eat can play a significant role in our health and well-being and may even impact longevity. Because of the significance of eating on well-being, diet interventions receive extensive attention in the media. Among different types of dietary interventions, fasting is emerging as the most significant; current research suggests that changing ones eating habits by reducing caloric intake, when coupled with modifying meals schedules may delay or prevent the onset of many types of diseases and extend years of functionality to cells, tissues and organs.

Dr. Valter Longo, director of the USC Longevity Institute, has done numerous studies supporting the positive effects of fasting on longevity. The rationale of fasting to improve health can be explained, in part, by the Disposable Soma Theory, a major theory in physiology of aging studies. This theory posits that the notion of senescence is the decrease in an organisms ability to reproduce and causes a related increase in the chances it will die as it ages. It assumes that the body needs to budget and appropriate the energy for various tasks to maintain subsistence. In allocating energy for different physiological activities, there is a tradeoff between using it for reproduction or for cell, tissue or organ repair.

In other words, if a substantial proportion of available energy is used for growing new tissues, less energy will remain for reproduction, regeneration and repair of existing body components. When we eat less food, our systems may interpret this behavior as a signal that the energy acquired from digesting food is becoming scarce. Therefore, our body will adjust so as not to deplete remaining energy by using too much of the it for reproductive activities. Instead, the body will focus more on maintaining the function of existing tissues and wait for a more suitable time to reproduce. As a result, existing tissues will be better maintained and protected. In maintenance mode, our body systems, tissues and organs will be kept strong and healthy. That is a general explanation on how fasting can reduce morbidity and contribute to longevity.

Fasting refers to purposefully restricting ones diet for a specific period. Traditionally, fasting was practiced in the manner of continuous caloric restriction, but the development of clinical trials and carefully designed programs have enriched our understanding of the effects of calorie-restricted fasting. Andrea Di Francesco, Clara Di Germanio, Michel Bernier, and Rafael de Cabo (2018) categorized fasting in four domains:

Human beings have practiced fasting and the unpleasant variance we know as starvation. However, because of their using unsophisticated medical technologies, the potential health benefits of fasting were not noted adequately. Today, fasting is receiving more attention and current scientific, social and economic developments make the health and beauty effects of fasting more attractive to consider. We have basic recommendations for those who may be considering one of these fasting options:

First, when deciding to practice fasting, take the time to do some research on possible negative outcomes. This will enhance your health literacy regarding fasting and possible consequences.

Second, before beginning a program of fasting, consult with a professional nutritionist on how best to proceed. For people who have no experience in fasting, suddenly being deprived of certain foods may be challenging; therefore, it is necessary to take a strategic approach to dieting to improve the odds of achieving diet goals.

Third, if it becomes impossible to tolerate the dietary restrictions, feel free to give up and restart when further motivated. The first few days of fasting could be difficult to bear. If the uncomfortable feelings have exceeded our level of tolerance, we should not feel guilty. Sometimes, ones own body may recognize that to continue fasting may result in unintentional, negative consequences to our health and well-being. Often, we can back off for a period and restart fasting when we are so inclined.

Remember that unless approached systematically, after undertaking weight-loss dieting, the weight lost often comes back and, even worse, additional pounds may accrue without carefully maintaining diet guidelines.

If you have questions, or comments about this article, please contact the authors at usc.rxxlab@gmail.com.

Disclaimer: Persons with eating disorders should consult with a physician before considering any fasting diet.

Mengzhao Yan, MA, Senior Lab Assistant; Erin Crutcher, MSG Candidate, Research Assistant; George Shannon, MSG, PhD; Director, USC Rongxiang Xu Regenerative Life Science Lab (RxX Lab).

More:
Fasting to Enhance Longevity? - L.A. Weekly

Welbeck Children’s partners with National Forest – The Bookseller

Published December 11, 2020 by Ruth Comerford

Welbeck Childrens has announced a new partnership with environmentcharity and non-profit organisationthe National Forest,as it prepares to publish non-fictionpicture bookWhat Did the Tree See?by Charlotte...

Welbeck Childrens has announced a new partnership with environmentcharity and non-profit organisationthe National Forest, as it prepares to publish non-fiction picture bookWhat Did the Tree See? by Charlotte Guillain, illustrated by Sam Usher, in the new year.

The partnership will see a percentage of the book's sales goto the National Forest, to support its woodland creation and management programmes. The National Forest isgrowing trees across 200 square miles of the Midlands. It is the first forest to be created at scale in England for over 1,000 years.

Told in rhyming verse, What Did the Tree See? follows the story of an oak tree on a hilltop as it witnesses life changing around it over the course of hundreds of years, from the time when hunters chased deer through the woodland, to when trees were cleared for farmland, to the smog and factories emerging during the Industrial Revolution. Accompanying pages at the end of the book include a timeline of events in world history across the periods featured in the poem,the lifecycle of an oak tree, and prompts to help parents and children explore their own local history.

Partnership activities will include schools engagement and promotion of experiences that encourage families and schools to visit the forest, or explore their local woodlands while sharing the books messages, such as finding out if there is a project to plant more trees where they live or watching trees grow through the changing seasons.

Welbeck Childrens will be providing the National Forest with supporting resources, including activity packs and a digital poster.

David Bourque, director of development at the National Forest, said:"We are delighted to be partnering with Welbeck Childrens and its beautiful new title What Did the Tree See?. The book highlights the longevity and power of some of our most special trees and how fragile the balance is between the environment and human development. We need to make sure we get that balance right for the next generation. In terms of publishing, Welbeck Childrens use of FSC paper and soy inks reflect how their industry is innovating in response to climate change something we want to see more of at the National Forest."

Jane Harris, childrens group publisher, said: "Our partnership with the National Forest is part of a broader commitment to sustainability for Welbeck Publishing. It is exciting to be able to support such a great cause with this beautiful new book for children."

What Did theTree See?will be published on18th February 2021.

The rest is here:
Welbeck Children's partners with National Forest - The Bookseller

Biopharma Money on the Move: December 2 – 8 – BioSpace

December is bringing frost in the North and plenty of cold hard cash for these life sciences companies.

Forbion

European venture capital firmForbionrounded up$545 millionfor its fifthlife sciences fund. Investments will be made in about 15 therapeutics companies, with a third created byForbionthrough its Build opportunities. The rest will be invested in highly impactful existing companies.With offices in the Netherlands, Germany and Singapore, theplan is to invest about 80% into Europeancompanies and the rest in North American startups.

AbCellera

Since partnering with Eli Lilly to produce the first monoclonal antibody therapyapprovedfor mild-to-moderate COVID-19 patients,antibody discovery companyAbCellerais going big on the Nasdaq. Offering 23 million shares between $14-$17 apiecefor a hopeful total of$391 million, the company is lining up the biggest debut on record for a Canadian biotech.AbCellerasAI-powered antibody discovery platform speeds theotherwise lengthy and gruelingprocessby analyzing the database of natural immune systems to findantibodies that canbe developed into drugs.Thepromiseto partners is to move quickly. Reduce cost. Tackle the toughest problems in drug development. Investors include big names like Peter Thiel, Bill and Melinda Gates Foundation and more.

Silverback Therapeutics

Silverback goes for gold, upping its IPO for a4thtimesince the initial announcement. Originally slated for $125 million,the biotech is now shooting for a$241 millionraise by offering 11.5 million shares at $21 each. Some of the funds will be used for thedevelopment of therapeutics for oncology and other serious diseases through its proprietaryImmunoTACtechnology platform.TheImmunoTACplatform pairs proprietary payloads that modulate key disease modifying pathways with monoclonal antibodies directed at specific disease sites. Silverbacks lead candidate is currently in a Phase I trial in adults with HER2-expressing solid tumors.

Nuance Pharma

Theres nothing subtle about Nuances$181 millionSeries D financing round. The fully integrated pharmaceutical company creates value through Chinas specialty pharmaceutical markets with focus on iron deficiency, pain management and respiratory.Now poised to advance a robust therapeutics pipeline to clinical development, Nuance will use the funds for ongoing R&D of existing products and business development of potential new assets.

SigilonTherapeutics

Now live on the ticker,Sigilonhopes to sell 7 million shares fora$126 millionraise.Through its Shielded Living Therapeutics platform, the company is developing functional cures for chronic diseases. The companysproduct candidates consist of novel human cells engineered to produce the crucial proteins, enzymes or factors needed by patients living with chronic diseases such as hemophilia, diabetes and lysosomal storage disorders. The engineered cells are protected bySigilonsAfibromer biomaterials matrix, which shields them from immune rejection and fibrosis. In March, the company closed an $80.3 million Series B.

RayzeBio

Launched in October with a$45 million Series A,RayzeBioput a Series B on their Christmas list and Santa came early.With a pipeline of targeted radiopharmaceuticals against validated solid tumors, the biotech looks toutilizethe$105 millionraise into advancing their programs toward the clinic.Thecompanys goal is focused on improving outcomes for cancer patients by harnessing the power of targeted radioisotopes.RayzeBiois alsofunneling cash intoexpandingits HQ in San Diego with plans to further develop internal R&D.

SciNeuroPharmaceuticals

Cornering the untapped Chinese CNS market,SciNeurolaunched with$100 millionin their pocket. Headquartered in Shanghai, the company will also have a hub in Philadelphia.CEO and founder Min Li knows a thing or two from his time running GSKs neuro R&D group before the company shuttered the program in 2017.Li stated, One in every six people in China is living with a CNS condition, yet there are relatively few effective treatments available today, underscoring the urgent need to develop and deliver novel, effective therapies. The impact of CNS diseases extends beyond patientsto their families and society as well. Theassumption isSciNeurowill start with Parkinsons diseaseand painin addition to rare genetic diseases, after scaling up staffing.

BioAge

Looking to extend the humanhealthspan,BioAgeraised$90 millionin an oversubscribed Series C. The companyis at the forefront of understanding the biological drivers of aging with its unique and cutting-edge systems biology platform. A supporting pipeline has medicines to target these key pathways to reverse or eradicate disease and extend the years of healthy life remaining.BioAgeis on the cusp of takingpilot therapies BGE-117 and BGE-175 into clinical trials, targetingthe first half of 2021.According to a press release, proceeds from the financing will be used to build and develop a diversified portfolio of therapies that increasehealthspanand lifespan, augmentBioAgesartificial intelligence (AI)-driven approach to map the molecular pathways that impact human longevity, and further expand capabilities to test drug candidates in predictive models of human diseases of aging.

Remix Therapeutics

Laying down a new track for RNA processing, Remix launched with$81 millionin financing. Funds will be used to support development of theREMastertechnology platform and advance the companys pipeline of RNA processing targeted therapeutics as well.As we reach the limits of what is easily druggable with protein targeting therapies, reprogramming RNA processing represents an exciting new therapeutic opportunity. We believe we can precisely target the cellular complexes that process RNA to address the underlying drivers of disease, working upstream of protein expression, said Pete Smith, Ph.D., co-founder, president and CSO of Remix Therapeutics and Atlas Venture Entrepreneur in Residence.

Pear Therapeutics

Pear picked a sweet dealthis weekwith an$80 millionseries D backed by Temasek, 5am Ventures, Novartis andquite a fewmore.Combining biology and technology, the company specializes in Prescription Digital Therapeutics (PDTs),a new therapeutic class that treats serious disease alone or with drugs using software. PearsreSET,reSET-OandSomrystare the first PDTs to receive FDA approval for treating disease. The products are used to treat substanceuse disorder,opioid use disordersand chronic insomnia, respectively. Series D funds will be used to acceleratereimbursementcoveragefor its three commercial products.

Noema Pharma

Co-founded by the former VP of neuroscience for Roche, Noema Pharma raised$59 millionin a Series A round. With an intent to develop treatment for rare neurological disease whereexisting therapies have not shown much success, the company has licensed four clinical stage assets from Roche. The Roche-assets are aimed at seizures in tuberous sclerosis complex (TSC), trigeminal neuralgia, Tourettesyndrome and other rare neurologicaldisorders.Already having been in clinical studies at Roche, all four candidates have strong clinical and preclinical safety packages. Thisshouldallow Noemato quickly pursue a series of clinical programs in orphan central nervous system (CNS) indications.

Most read today on BioSpace:

View post:
Biopharma Money on the Move: December 2 - 8 - BioSpace

Stem Cell Market Analysis By Industry Value, Market Size, Top Companies And Growth Forecast To 2027 – Cheshire Media

Wilmington, November, 2020: Axiom Market Research & Consulting added a report on global Stem Cell which includes study on various market segments across various countries of key regions across the globe. Post COVID-19 pandemic impressive growth anticipated for this market. The global market is estimated and forecasted in terms of revenue (USD Million) generated by the Stem Cell market.

Get Sample PDF Copy @ https://www.axiommrc.com/rqs/1661-stem-cell-market-report

Major Players in Stem Cell Market

Some of the key participants in the stem cells market include Cytori Therapeutics, Inc., Mesoblast Ltd., Astellas Pharma Inc., STEMCELL Technologies Inc., Osiris Therapeutics Inc, Celgene Corporation, BioTime, Inc., Cynata Therapeutics Limited, Human Longevity Inc, Cellular Engineering Technologies Inc., U.S. Stem Cell, Inc. BrainStorm Cell Therapeutics Inc. Caladrius Biosciences, Inc., and Promethera Biosciences.

Covid-19 Impact Analysis on Stem Cell Market

The global pandemic of Coronavirus (COVID-19) has triggered stock market unpredictability, tight border controls, and worldwide lockdown, leading the biotechnology industry, as well as large companies and governments, to restock supply chains. The whole world is experiencing severe impact on social and financial sectors, and all global industries are facing challenges during the COVID-19 pandemic. The exclusive COVID-19 Impact Analysis report by Axiom MRC explores the outbreak of COVID-19, its impact on the global and regional economies, and its implications on the healthcare sector. The report studies the effect of the pandemic on the global economy by evaluating factors like consumption, GDP, business investment, key players marketing strategies, key supply and demand-side factors, epidemiological swing factors, inventory, and governmental policies & decisions.

Stem Cell Market Segmental Highlights

Axiom has better understanding of various market segments due to its in-depth value chain analysis. Market size and forecast for the major market segments in terms of value and volume for the forecast period 2019 to 2027 presented in the report

Purchase This Report @ https://www.axiommrc.com/buy_now/1661-stem-cell-market-report

Stem Cell Market Regional Analysis

This study includes market size, share trend, competitive intelligence of developed markets, growth markets and niche regions/countries of:

Research objectives and key highlights of the market study:-

About us:

Axiom Market Research & Consulting is leading market research, business consulting and data analytics company serving the Fortune 5000 companies organizations of Healthcare, Chemicals, Food and Beverage, Technology etc. with quality solutions.

Contact us:

Call: USA +1(845)875-9786/UK +44(0)20 3286 9707/India +91 7020 342806

Email: [emailprotected]

Read this article:
Stem Cell Market Analysis By Industry Value, Market Size, Top Companies And Growth Forecast To 2027 - Cheshire Media

BioAge Raises $90M to Treat Aging and Age-related Diseases – GlobeNewswire

Proceeds will support advancement of the companys pipeline and proprietary platform for identifying and developing therapies to treat diseases of aging

Company announces Chief Medical Officer as it prepares to enter clinic in 2021 with lead Phase 2-ready therapeutic compounds

RICHMOND, Calif., Dec. 03, 2020 (GLOBE NEWSWIRE) -- BioAge Labs, Inc., a biotechnology company developing medicines to treat aging and aging-related diseases, today announced that it has raised $90 million in an oversubscribed Series C financing. The raise was co-led by Andreessen Horowitz and serial entrepreneur, Elad Gil, and included new investors Kaiser Foundation Hospitals, AARP Foundation (through the RockCreek Impact Fund) and Phi-X Capital, the fund of genomics entrepreneur Mostafa Ronaghi, among others. Current investors including Caffeinated Capital, Redpoint Ventures, PEAR Ventures, AME Cloud Ventures, Felicis Ventures, and others also participated.

These additional funds will support advancement of our systems biology and data-driven platform to map the key pathways that drive human aging and our pipeline of medicines that target these pathways to reverse or eradicate diseases and extend healthspan, said Kristen Fortney, PhD, co-founder and chief executive officer. We look forward to advancing our first platform-derived therapies, BGE-117 and BGE-175 into clinical trials in the first half of 2021.

BioAge is at the forefront of understanding scientific drivers of aging with its unique and cutting-edge systems biology platform. We believe their approach has the potential to unlock the underlying pathologies of many diseases, such as Alzheimers, cardiovascular disease, and frailty, that disproportionately affect older populations, said Vijay Pande, PhD, general partner at Andreessen Horowitz.

Drugs that target aging have potential to treat several morbid diseases and improve the lives of older adults. BioAge has built a proprietary engine to analyze molecular signatures in aging populations, and to advance data-driven hypotheses to identify existing clinical-stage drugs that are ready for Phase 2 efficacy trials in age-related diseases. Im excited to work with them as they scale their platform and develop multiple therapies to improve the health of older individuals, said Elad Gil, PhD, entrepreneur and investor.

Proceeds from the financing will be used to build and develop a diversified portfolio of therapies that increase healthspan and lifespan, augment BioAges artificial intelligence (AI)-driven approach to map the molecular pathways that impact human longevity, and further expand capabilities to test drug candidates in predictive models of human diseases of aging.

Separately, the company announced that Paul Rubin, M.D. will lead its clinical development efforts as chief medical officer. Dr. Rubin, a veteran biopharmaceutical drug developer, brings extensive experience from early discovery, late stage development and ultimate drug approvals across a wide variety of therapeutic areas in global geographies. In former roles heading development at Sepracor, GSK and Abbott, Dr. Rubin has been responsible for the clinical development and approval of more than ten products. Prior to BioAge, he was most recently executive vice president, Research and Development for MiRagen and held a similar role at Xoma, two biotechnology companies. Dr. Rubin earned his M.D. at Rush Medical College, Chicago.

Dr. Rubin commented, I am thrilled to be leading the BioAge clinical development team at this exciting time. Our platform provides a unique opportunity to identify targets relevant to the aging process and diseases associated with this process. Diseases common to older patients are often ignored despite their direct association with morbidity, mortality and decreased quality of life. The first two drugs from our pipeline are ready to begin Phase 2 trials in indications targeting serious conditions in elderly populations that presently have no good therapeutic options. A key aspect of our strategy is to initiate efficient human clinical trials that will demonstrate that our drugs can address age-related deficiencies in acute conditions, which may expedite approval and serve as a gateway to the treatment of chronic diseases, resulting in healthy aging.

About the BioAge Platform

The BioAge platform identifies key drug targets that will impact aging. The companys proprietary human aging cohorts have blood samples collected up to 45 years ago, with participant -omics data that is tied to extensive medical follow-up records including detailed future healthspan, lifespan and disease outcomes. BioAge has built a systems biology and AI platform that leverages these rich datasets to identify the molecular drivers of age-related pathology. BioAges pipeline of therapies targeting these key pathways will address the significant unmet medical needs of an aging population.

About BioAge

BioAge is a privately-held biotechnology company developing proprietary drugs to treat aging and aging- related diseases. Since its founding in 2015, the Company has raised $127 million in venture capital funding to back its AI-driven approach to map the molecular pathways that impact human longevity. BioAges mission is to develop a pipeline of therapeutic assets that increase healthspan and lifespan. For additional information about BioAge, visit the companys website at http://www.bioagelabs.com.

Source: BioAge Labs, Inc.

Contact Information:

BioAge | peng@bioagelabs.com

Media | swheeler@wheelhouselsa.com

Read more from the original source:
BioAge Raises $90M to Treat Aging and Age-related Diseases - GlobeNewswire

The 6 Best Diets That Will Make You Live Longer, Say Dietitians – Eat This, Not That

As we look forward to 2021, many of us have started to think about New Year's resolutions. For those of us looking to lose weight over the next twelve months, a brand new diet can not only help us hit our weight loss goals, but also introduces us to new foods, raises our energy levels, and helps us live longer, more fulfilled lives. And yet, if you decide to embark on a brand new diet, figuring out which plan to follow can feel mind-boggling. Trying to sort between the best diets to live longer and the not-so-great fad diets only makes losing weight that much harder.

So if you feel overwhelmed by the world of dieting and have no idea of where to start, have no fear! To help streamline your weight loss process and guarantee a long and healthy life, we talked to a wide range of registered dietitians, nutritionists, and medical doctors to assemble the top six diets that help you live longer. By eating healthy and exercising regularly, you can stay one step ahead of weight gain and keep moving for decades to come.

Read on to learn which six diets can help you live longer, and for even more healthy tips, be sure to check out our list of The 7 Healthiest Foods to Eat Right Now.

"The Mediterranean diet has consistently been ranked by US News & World Report as the world's best overall diet," says Lexi Endicott, RD, LD, and culinary nutrition specialist for To Taste. "Rather than a diet in the traditional sense in which you go on it to eventually go off it, the Mediterranean Diet is a simple and sustainable eating pattern that can be followed for life. This eating pattern emphasizes consuming a variety of plant foodsa plant-forward diet, so to speak."

If you feel ready to take the plunge, the nutritional benefits of this eating plan can keep you healthy for years.

"These healthful foods [and] ingredients are rich in vitamins, minerals, and phytochemicals (i.e. antioxidants) that decrease risk of developing many chronic diseases such as heart disease, cancer, diabetes, and Alzheimer's," says Endicott. "The more disease-free years someone can add to their life, the better!"

If you want to really super boost your chances for longevity, check out our list of 20 Foods You Should Be Eating Every Day for a Longer Life.

Eating less can definitely help you lose weight, but it might also keep you around much longer.

"The diet that has the most empirical evidence in regards to increasing life expectancy is intermittent fasting or even fasting in general," says Dr. Alexander Lightstone Borsand, MD. "Animal studies have shown that the less often animals eat, the longer they live in comparison to animals fed more regularly. The most notable study in humans followed 2,000 patients after cardiac catheterization and showed an increased lifespan in patients who regularly fasted."

"Another animal study showed that mice that were fed once a day had an 11% increase in lifespan as compared to the mice fed multiple times a day," says Dr. Borsand. "This is a significant increase in lifespan and warrants further human studies."

Here are7 Science-Backed Benefits of Intermittent Fasting.

If you haven't heard of the DASH diet, get ready for an eating plan that can change your life. The Dietary Approaches to Stop Hypertension diet encourages the consumption of foods that lower blood pressure has taken off in recent years, and can do some wonders.

"The science is very clear that a plant-based or plant-forward diet is quite remarkable for its positive impact on longevity and healthspan," says Dr. Nicole Harkin, MD, FACC, founder and cardiologist of Whole Heart Cardiology. "This diet is high in vegetables, fruits, whole grains, legumes/beans, nuts, and seeds while minimizing or eliminating animal products and processed packaged foods."

"Numerous epidemiologic studieshave demonstrated that an increased intake of plant-based foods results in reduced risk of cardiovascular and other causes of death," says Dr. Harkin. "We also see a decreased risk of obesity, high blood pressure, high cholesterol, diabetes, and inflammation. While not all individuals may not be ready to go completely plant-based, working on incorporating as many plant-based foods and #meatlessmondays is a great first step!"

Here is Everything You Need to Know About the DASH Diet.

What do Greece, Japan, Italy, California, and Costa Rica have in common? These areas constitute Blue Zonesareas of the world with the highest concentration of centenarians. In order to live like someone who could reach 100, you need to eat like someone who can reach 100, and this diet helps you do just that!

"The Blue Zones have several lifestyle factors in common which appear to contribute to the longevity and increased likelihood of living to 100 years of age," says Dr. Christine Bishara, MD, founder of From Within Medical. "Their diets are composed of fresh whole foods which are primarily plant-based and also include nuts, legumes, and olive oil. They incorporate minimal red meat with the majority of the animal protein components coming from pescetarian options."

They do not eat heavy meals late in the day or close to bedtime," says Dr. Bishara. "They practice socially based eating and have strong ties to their community. This has been studied numerous times as a major factor in longevity including another study called 'The Roseto Effect'[ and] they live in areas with ease of daily walking as a form of exercise. This seems to also be another well-studied contributor to longevity."

People in the blue zone typically eat this One Food You Should Be Eating Every Day For a Longer Life.

"Though it sounds like the latest trend, the carnivore diet is a diet that was followed for ages," Dr. Rashmi Byakod said. "The human race evolved from eating raw and cooked meat. In the olden days, there was no agriculture, and plant food was the least consumed. Meat foods are highly nutritious and carry numerous health benefits."

If you ever considered yourself a "meatatarian" you might actually be onto something.

"The aging process indicates impairment of mitochondrial function, reduced antioxidant effect, and increased oxidative stress," says Dr. Byakod. "Selenium and Coenzyme Q10 (CoQ10) present in meats have antioxidant effects helping in longevity and wellbeingOther than these, meats are a good source of vitamin D, omega 3 amino acids, and various other nutrients. Adapting to a carnivore diet can help you meet all the nutritional requirements of your body."

If you love the idea of the Mediterranean diet, but don't want to cut our dairy, this diet will make you swoon.

"Dairy, especially full-fat dairy, contains healthy fats, calcium, and other nutrients that are recommended for a healthy diet," says Lisa Richards, CNC. "It is easy to integrate more servings of dairy into the traditional Mediterranean diet through cheeses, yogurt, and dairy-based sauces."

"Adding dairy to the Mediterranean Diet could make it more sustainable long-term, especially for women who need the added calcium and vitamin D," says Richards. "The fat content may deter some people as it adds additional fat to an already moderate fat diet, however, easy exchanges can be made to ensure a balance of fish and plant fat with added dairy."

"As with any diet, moderation is important," says Richards. "The foods recommended on the Mediterranean Diet are not shown to be unhealthy for your heart. However, the dieter should make sure they are still staying within their calorie limits, especially with fat content, to avoid any negative side effects."

For more on the Candida Diet: This Is Everything You Should Eat and Why, According to Experts.

Continued here:
The 6 Best Diets That Will Make You Live Longer, Say Dietitians - Eat This, Not That

4 Companies At The Center Of The Telemedicine And Digital Health Revolution – Seeking Alpha

The rapid adoption of telemedicine and digital health during COVID-19 pandemic is remarkable, yet unsurprising. In the years preceding the health crisis we now find ourselves in, a paradigm shift in health care toward digitization was percolating. Structural trends like health care inequality, human longevity, systemic inefficiency, and improving connectivity served as kindling for the seemingly inevitable, albeit gradual adoption of technology in the sector.

2020's global lockdowns and widespread infection fears ignited said kindling. Since March, we've witnessed levels of technological disruption typical of years, not mere months. FAIR Health reports telemedicine claim lines increased about 84x from April 2019 to April 2020.1 Artificial intelligence (A.I.)-equipped health care analytics software became a valuable tool for drug and vaccine development, symptom identification, and hospital triaging.2 Connected devices like health tracking wearables and smart thermometers became commonplace, while those found in remote intensive care units allowed doctors to treat patients without risking their own health. In other words, telemedicine and digital health arrived.

In the following piece, we explore four key companies at the center of this rapidly emerging theme.

Teladoc Health (NYSE:TDOC) is a telemedicine company that connects patients with health care providers over the phone, through video chat, and on the Teladoc platform. Teladoc's primary services include:

Usage of Teladoc's platform has surged through the pandemic as patients seek medical care without risking infection from in-person visits. In Q2 2020, during pandemic's initial surge, Teladoc provided 2.8 million virtual health care visits, up 200% year-over-year (YoY).6 Many expected visits to decrease as COVID-19 infections subsided over the summer, but Q3 usage levels remained steady with Teladoc yet again recording another 2.8 million.7 As of the end of Q3, Teladoc had 51.5 million members, up 47% YoY. Also of note, in October, Teladoc completed its acquisition of remote health monitoring company, Livongo (NASDAQ:LVGO), for $18.5B in cash and stock. The deal integrates Livongo's established remote monitoring technology with Teladoc's telemedicine infrastructure, broadening and possibly solidifying Teladoc's standing as a leader in virtual care.8

Nuance Communications (NASDAQ:NUAN) offers a suite of products that enable digital transformation in health care, spanning the health care analytics and administrative digitization segments. These include:

Nuance's health care analytics and administrative digitization products continued to show strength throughout the pandemic. In Q4 of their 2020 fiscal year, Nuance reported continued growth for Dragon Medical One (DMO), with penetration in the US reaching 43% and with segment revenues growing 26% YoY. The product is growing internationally, too, reaching 14 countries and showing notable strength in the United Kingdom. DMO's strength comes in tandem with increased adoption of Nuance's cloud-based health care platform, with both products benefitting from shared synergies and the general trend of digitization.

iRhythm Technologies (NASDAQ:IRTC) develops and sells solutions for monitoring cardiac health and detecting cardiac arrhythmias. Their products include:

In Q2 2020, in the midst of the pandemic, iRhythm's leadership noted how the current environment offers "considerable potential for structural changes to how healthcare is delivered, and that will play to the strengths of [their] digital platform."14 Q3 validated this sentiment with a significant number of clients prescribing Zio at a higher clip than at the beginning of the year, despite the pandemic easing during the quarter. Additionally, the rise of telemedicine drove greater enrollments on the Zio platform, illustrating how the theme's sub-segments are both enablers and beneficiaries of each other.

Invitae Corporation (NYSE:NVTA) provides patients and providers with germline genetic testing and offers libraries of genetic data for health care provider implementation. Invitae's data provides insights around the risk of developing cancer and other diseases based on mutations found in cellular DNA. This can be extremely useful for patients looking to proactively understand their health risks and for providers looking to offer their patients the best care available.

Genetic data has become increasingly valuable during the pandemic as it is becoming apparent that certain genetic risks increase the lethality of COVID-19. Invitae's Q3 2020 results reflect these developments as testing volumes grew 32% YoY and 41% compared to the previous quarter. Additionally, Invitae closed on a $1.4B deal to acquire Archer DX, increasing their offering to include somatic testing which looks at genetic changes seen in tumors. The potential market for genetic testing is vast, and companies like Invitae are making this technology and information more readily available to patients around the world.15

Despite impressive advancements in recording and analyzing health care data and in connected medical devices, the healthcare sector was slow to embrace the digital transformation offered by these technologies for many years. The COVID-19 pandemic finally put this disruption in motion. As illustrated by the compelling products and services mentioned above, solutions that enable remote medicine, advanced patient monitoring, A.I.-driven insights, and streamlined healthcare administration are rapidly being implemented around the world. In our view, the benefits seen by patients, providers, and payers will continue to drive the theme's growth moving forward.

FOOTNOTES

1. Fair Health, "Telehealth Claim Lines Increase 8,336 Percent Nationally from April 2019 to April 2020," July 7, 2020.

2. The Medical Futurist, "The (Sober) State of Artificial Intelligence in the Fight Against COVID-19," April 14, 2020.

3. Teladoc, "Virtual Primary Care," 2020.

4. Teladoc, "What We Do," 2020.

5. Ibid.

6. Teladoc Q2 Earnings Call

7. Teladoc Q3 Earnings Call

8. Med City News, "Teladoc, Livongo finalize $18.5B merger," Oct 30, 2020.

9. Nuance Communications, "Provider Solutions," 2020.

10. Ibid.

11. Ibid.

12. iRhythm, "Zio XT," 2020.

13. iRhythm, "The Zio Service," 2020.

14. iRhythm Q2 Earnings Call

15. Invitae Q3 Earnings Call

Investing involves risk, including the possible loss of principal. The investable universe of companies in which EDOC may invest may be limited. The Fund invests in securities of companies engaged in the Health Care and Information Technology sectors. These sectors can be affected by government regulations, rapid product obsolescence, intense industry competition and loss or impairment of patents or intellectual property rights. International investments may involve risk of capital loss from unfavorable fluctuation in currency values, from differences in generally accepted accounting principles or from social, economic or political instability in other nations. EDOC is non-diversified.

This information contains a manager's opinion, is not intended to be individual or personalized investment or tax advice, and should not be used for trading purposes.

Shares of ETFs are bought and sold at market price (not NAV) and are not individually redeemed from the Fund. Brokerage commissions will reduce returns.

Carefully consider the funds' investment objectives, risks, and charges and expenses. This and other information can be found in the funds' full or summary prospectuses, which may be obtained at globalxetfs.com. Please read the prospectus carefully before investing.

Global X Management Company LLC serves as an advisor to Global X Funds. The Funds are distributed by SEI Investments Distribution Co. (SIDCO), which is not affiliated with Global X Management Company LLC.

Original Post

Editor's Note: The summary bullets for this article were chosen by Seeking Alpha editors.

Read more from the original source:
4 Companies At The Center Of The Telemedicine And Digital Health Revolution - Seeking Alpha

Quote Of The Week: Zach Bush MD On World Microbiome Day – Longevity LIVE – Longevity LIVE

Zach Bush MD, is an internationally recognized educator and thought leader on the microbiome as it relates to health, disease, and food systems. Celebrating World Microbiome Day on 27th June 2021, he explained why theres no better time to pay tribute to the microbiome.

As human beings, our neurologic capacity begins with our connection to the microbiome Zach Bush MD

In his latest weekly newsletter, Bush said, It is, in its entirety, vital to life and the reason why we are here today. Without the microbiome, life on Earth would not exist.

At its most basic definition, micro means small, and biome means living creatures essentially all of the living microbes on and inside the human body. Today, we know human cells are not at the foundation of the human microbiome, but rather its the fungi and bacteria that are. It is estimated that we have 50 to 70 trillion human cells, which pale in comparison to the 1.4 quadrillion bacteria and 10 quadrillion fungi inside our bodies.

He explained further that as we learn more about the microbiome and our human biology, its clear that this diverse non-human micro ecosystem is what makes life possible. Its what fuels our development, immunity, and nutrition, enabling our production of energy, micronutrients, and regenerative pathways. Within every organ system throughout our whole body, its this unique niche of bacteria, fungi, and yeast that nurture our human cells.

Get out! Kick off the shoes, walk in a garden, on a forest path, a beach, a meadow, or a mountain top. Zach Bush, MD

World Microbiome Day was celebrated on the 27th June. You can read more about it here: #microbiome4life

Zach Bush MD is a physician specializing in internal medicine, endocrinology and hospice care. He is an internationally recognized educator and thought leader on the microbiome as it relates to health, disease, and food systems. Dr Zach founded *Seraphic Group and the nonprofit Farmers Footprint to develop root-cause solutions for human and ecological health. His passion for education reaches across many disciplines, including topics such as the role of soil and water ecosystems in human genomics, immunity, and gut/brain health. His education has highlighted the need for a radical departure from chemical farming and pharmacy, and his ongoing efforts are providing a path for consumers, farmers, and mega-industries to work together for a healthy future for people and planet.

Link:
Quote Of The Week: Zach Bush MD On World Microbiome Day - Longevity LIVE - Longevity LIVE

Planet Earth Report Strange Unexplained Circles in Space to Software Map That Could Change the World Forever – The Daily Galaxy –Great Discoveries…

Posted on Dec 27, 2020 in Science

Planet Earth Report provides descriptive links to headline news by leading science journalists about the extraordinary discoveries, technology, people, and events changing our knowledge of Planet Earth and the future of the human species.

Ghostly Circles in Space Cant be Explained by Current Theories Among them was a picture of a strange circle of radio emission, hanging out in space like a cosmic smoke-ring reports astronomer Ray Norris for The Conversation. None of us had ever seen anything like it before, and we had no idea what it was, report scientists examining new images from pilot observations for the Evolutionary Map of the Universe (EMU) project, made with CSIROs revolutionary new Australian Square Kilometer Array Pathfinder (ASKAP) telescope.

How a Software Map of the Entire Planet Could Change the World Forever, reports Aaron Frank for the Oxford Business Review. Why 3D map data is the technology infrastructure for the 21st Century 3D maps like these are essentially software copies of the real world. They will be crucial to the development of a wide range of emerging technologies including autonomous driving, drone delivery, robotics, and a fast-approaching future filled with augmented reality.

The Darkest Timeline Deep Adaptation made people confront the end of the world from climate change. Does it matter if its not correct? asks Jonah Engel Bromwich for the New York Times.

The Mysterious Link Between COVID-19 and Sleep, reports James Hamblin for The Atlantic. The coronavirus can cause insomnia and long-term changes in our nervous systems. But sleep could also be a key to ending the pandemic.

From Elvis worms to the Milky Ways edge, these science stories sparked joy in 2020, reports Science News. From Flowers at the South Pole to microbes that had been buried in seafloor sediments for more than 100 million years revived and multiplied.

How scientists plan to protect Earth from extraterrestrial germs, reports Rebecca Renner for National Geographic. As missions return more cosmic material, cautious space agencies are building highly secure biosafety labs to keep the precious cargo contained.

The shadowy spirits that helped advance science A demon was present at the birth of science.. Ren Descartes conjured an evil genius when devising his I think, therefore I am statement about the nature of reality and the self. Other scientific demons would follow over the centuries, reports Jess Keiser for The Washington Post. Descartes realized that in order to establish anything at all in the sciences that was stable and likely to last, he first needed to lash himself to a single point of certainty in a roiling sea of doubt.

Wild Things Space Invaders Season 2: The Search for Extraterrestrial Life (Best Space Podcast of 2020) Whats the likelihood that, as were looking out into space, something else might be looking back at us? asks Host Laura Krantz. in recent years, armed with state-of-the-art technology and better information, the search for extraterrestrials overflows with exciting possibilities. Within our own solar system, astrobiologists search for the biochemical building blocks that might sustain microbes. Astronomers discover far-flung stars, orbited by planets that could be teeming with life. And astrophysicists point sophisticated (and expensive) telescopes toward the deep reaches of the universe, looking for anything out of the ordinary.

Zombie Gas Could Creep Through Arctic Ice, reports Elizabeth Rayne for SyFy Wire. Melting permafrost has revealed everything from Scythian graves to unbelievably intact Ice Age megafauna, but something else that has been lurking under frozen ground that was never supposed to melt. New research has now found that zombie greenhouse gases could seep through melting Arctic permafrost because of human activity that is causing it to melt and the organic matter in it to decompose. Carbon dioxide and methane had been trapped in undersea permafrost since mammoths and woolly rhinos roamed the Earthand are now reanimating.

The Secret to a Long, Healthy Life Is in the Genes of the Oldest Humans Alive, reports Shelly Fan for Singularity Hub. The key to human longevity, [a global team of scientists] say, lies in the genes of centenarians. These individuals not only live over 100 years, they also rarely suffer from common age-related diseases. That is, theyre healthy up to their last minute. If evolution was a scientist, then centenarians, and the rest of us, are two experimental groups in action. Nature has already given us a genetic blueprint for healthy longevity. We just need to decode it.

Monkey Brain Study Reveals the Engine of Consciousness, reports Grace Browne for Inverse. What exactly ignites consciousness has long been a mystery. But in a study published in February, the search became a bit narrower: to a powerful part of the brain known as the central lateral thalamus, a tiny region found deep in our forebrain.

The Worlds Space Agencies Are on a Quest to Deflect a (Harmless) Asteroid, reports Jason Dorrier for Singularity Hub. While the last killer space rock dropped out of the sky with no warning, we have a few tools the dinosaurs didnt. In addition to telescopes to chart potentially hazardous asteroids, we can visit and, theoretically, divert an asteroids course before it reaches us. Now, the worlds space agencies are teaming up to take planetary defense beyond theory.

Extraterrestrial evidence: 10 incredible findings about extraterrestrial life from 2020, reports Adam Mann for Live Science. Findings on the closest planet to us, in the outer solar system and the far beyond seemed to point to the possibility that other worlds could host organisms ranging from bacteria to technological beings. Perhaps, new results in the coming year will finally reveal who else might be out there.

2020 in review: The year governments slapped down big tech This was a year in which governments went head-to-head with big tech firms. US regulators were suing Facebook over its historic acquisitions of Instagram and WhatsApp, asking the courts to consider breaking up the company, reports New Scientist.

After Coronavirus the World Will Never Be the Same. But Maybe, It Can Be Better, reports Vanessa Bates Ramirez for Singularity Hub. Were making plans for what well do when things go back to normaland banking on that happening. But what if life never fully goes back to how it was pre-coronavirus? What if this epidemic is a turning point, and after it the world is never the same? More importantlyor, at least, more optimisticallywhat if the world could come out of this crisis better than it was before?

Rumors of a murder hornet apocalypse may have been exaggerated, reports Murder hornets sightings in the Pacific northwest inspired a mix of concern and delight, reports Science News.

The Wildest Animal News From 2020 These are the stories about birds, bugs, fish and mammals that surprised and delighted readers the most this year, reports Hannah Wise and Lily Benson for The New York Times. It was a rough year for Homo sapiens. The coronavirus pandemic highlighted our vulnerabilities in a natural world that is constantly changing. Many were pushed to find new levels of resolve and creativity to survive.

Here is the original post:
Planet Earth Report Strange Unexplained Circles in Space to Software Map That Could Change the World Forever - The Daily Galaxy --Great Discoveries...