Turn Biotechnologies Expands the Potential of its mRNA Platform by Licensing Unique Artificial Niche Technology – PRNewswire

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MOUNTAIN VIEW, Calif., Feb. 3, 2021 /PRNewswire/ --Turn Biotechnologies, a company developing medicines for currently untreatable age-related conditions, announced that it has acquired the global rights for new artificial niche (AN) technology that can be used to restore muscle stem cells damaged by aging.

The company licensed its AN technology from Stanford University, where it was developed by a researcher who serves as an advisor to Turn. AN technology is used to create a microenvironment that maintains stem cells in a quiescent state to repair or replace specific types of damaged tissue. The stem cell niche provides structural and trophic support and the appropriate homeostasis to regulate stem cell function.

Turn will use the niche technology in combination with its mRNA-based epigenetic reprogramming of age (ERA) technology to restore specific cells' youthful functionality, to trigger the body's ability to fight age-related diseases.

"Our artificial niche technology expands the applicability of our ERA technology to a variety of diseases involving tissue that requires a microenvironment to maintain cell quiescence," said Anja Krammer, Turn CEO. "By enveloping our ERA technology in the protective matrix of an artificial niche, we can reactivate muscle stem cells, as well as stem cells in tissues where quiescence is necessary to maintain stem cell functions."

The combined use of Turn's AN and ERA technologies may be able to restore function in hematopoietic, liver, brain, certain mesenchymal stem cells across different tissues and within the hair follicle.

This is Turn's second licensing announcement since the start of the year. Earlier, the company revealed that it acquired the global rights for its ERA technology from Stanford University, where it was developed by three researchers who founded Turn. It is the first technology to maintain cellular identity while restoring specific cells' youthful functionality, to trigger the body's ability to fight age-related diseases.

As with ERA, the company announced that it has filed for patents to protect its AN technology in major-market nations on six continents.

"This is significant for our pipeline because the combination of AN with our ERA technology in murine models shows increased potency," said Jay Sarkar, Turn's chief technology officer and a company founder who helped to develop the ERA technology. "The studies show that aged muscle stem cells treated with this combination therapy fully regenerate age-related muscle dysfunctions."

Turn's technology uses messenger RNA to produce instructions that induce cells to treat or prevent disease. Use of mRNA, which led to the quick development of two COVID-19 vaccines, promises to revolutionize the development of therapeutics by making that development safer, faster, more efficient and extremely tunable to patient need.

Turn is currently completing pre-clinical research on tailored therapies targeting indications in dermatology, ophthalmology, osteo-arthritis and cartilage damage and musculature.

ABOUT TURN BIOTECHNOLOGIES

Turn is a pre-clinical-stage company focused on repairing tissue at the cellular level. Our proprietary mRNA technology combats the effects of aging in the epigenome, thus restoring optimal gene expression and enabling cells to function as vigorously as when they were younger. Our technology provides a platform from which to attack a variety of diseases related to age. The company has the financial backing of Methuselah Fund, which focuses its investments to extend the healthy human lifespan; Formic Ventures, which invests in biotech start-ups focused on human longevity; and Shanda Group, a private global investment firm. For more information, see http://www.turn.bio.

FOR MORE INFORMATION, CONTACT:Jim Martinez, rightstorygroup[emailprotected] or (312) 543-9026

SOURCE Turn Biotechnologies

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Turn Biotechnologies Expands the Potential of its mRNA Platform by Licensing Unique Artificial Niche Technology - PRNewswire

Nagy: The president and the tsar – LubbockOnline.com

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TIBOR NAGY| Lubbock Avalanche-Journal

Churchill had some brilliant quotes, but his most famous one about Russia a riddle wrapped in a mystery inside an enigma. -- is wrong. Russias self-identified role in the world hasnt been a mystery since Napoleons wars, maybe even earlier: to protect its heartland by extending its control and influence as far as possible in every direction, and to perpetuate the privileges of its ruling class thru all possible means.

Through expansion under a succession of Tsars and Commissars the Russian landmass now covers 11 time zones and exerts influence much farther. While Russias vastness and bitter winters consistently defeated a series of enemies who had no problems overrunning the rest of Europe, its leaders have been less consistent in their capabilities. But its current tsar, President Vladimir Putin, is also one of its ablest understanding fully how to maximize Russias weakened global position. With the end of the Soviet Union in 1991, Russia lost about 25% of its territory, and as recently as 2009 was characterized as Burkina Faso with nuclear arms (meaning its economy relied on the export of natural resources).

But while Putin may be holding a pair of tens, hes playing them like a full house. Added to his mastery of history and geopolitics is his expertise in human behavior gleaned from decades of KGB tradecraft which makes him doubly dangerous as an adversary. He has a near perfect record of opportunistic timing on when/how to strike with calculated impunity: seizing Crimea, saving Assad in Syria, sending combat volunteers into eastern Ukraine, manipulating Western Europe to embrace his Nordstream II natural gas pipeline, winking at cybercriminals who inflict major damage on U.S. infrastructure and morale, and poisoning political opponents when he cant simply arrest and torture them.

But for once, going into a summit with a Russian leader, the U.S. side was represented by a president who himself has long political experience and doesnt suffer from naivete or geopolitical ignorance. The U.S. track record in these meetings has been poor: e.g. Roosevelt giving away Eastern Europe to Stalin and Kennedy coming off so weak to Khrushchev that the Soviets were emboldened to move nuclear missiles to Cuba. (Reagan being an exception who more than held his own against Gorbachev.) There will be thousands of words written analyzing the Biden/Putin Summit, but they matter little. What counts is what measure Putin took away from their meeting because that will determine how Putin will play his pair of tens during Bidens presidency.

Putin will stay as he has - searching for and exploiting whatever weaknesses he detects in the US leadership or the western alliance. He will use every geopolitical weapon he believes he can get away with, pursue the Big Lie as effectively as any Soviet leader ever did, neutralize his opponents with whatever means work, and continue to allow his cronies to amass immense wealth at the expense of his people. Russia is neither a mystery, riddle nor enigma. Russia will simply continue its centuries-long policy of opportunistically and brutally assuring its place in the world and the longevity of its ruling class.

Ambassador Tibor Nagy was most recently Assistant Secretary of State for Africa after serving as Texas Techs Vice Provost for International Affairs and a 30-year career as a US Diplomat.

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5 Ways To Stay Younger And More Creative As You Get Older – Forbes

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5 ways to develop a younger mindset

There is a fountain of youth: it is your mind, your talents, the creativity you bring to your life and the lives of people you love. When you learn to tap this source, you will truly have defeated age - Sophia Loren

With life expectancy steadily rising in most countries around the world, the number of people aged sixty-five years or older will rise sharply over the next two decades. And you might already be one of them.

Certainly, were already seeing far more centenarians and near-centenarians than ever before. Just a few weeks ago, the world was collectively awed by nonagenarian William Shatners trip to space as the worlds foray into space. Not long after, there were numerous news stories about Dr. Manfred Steiner earning his third doctorate at the age of 89. But there are hardly outliers. More than ever, we are seeing other examples of seniors in their eighties and beyond continuing to enrich the world with their achievements instead of settling into the decrepit old age far too many people pessimistically see in their own future.

But what is it that makes these super seniors so vibrant and active? Though it is easy to attribute this ability to stay young to good genes alone, the opposite seems to be the case. A ground-breaking Danish study published in 1995 examined more than 2500 twin pairs born between 19870 and 1900 and concluded that genetics only played a modest role (at best) in human longevity. Instead, non-genetic factors, including lifestyle choices and environmental stress appear far more important in determining how long people can remain active and healthy over time.

Perhaps as importantly, the attitudes that people have towards growing older are often shaped by the kind of negative stereotypes too many of us have. These stereotypes often result from cultural expectations as well as the experiences people have dealing with their aging parents and grandparents. Along with affecting how people treat older adults, these stereotypes can also make us pessimistic about our own aging and what we will be capable of as we grow older. According to Stereotype Embodiment Theory,

people who internalize their own negative beliefs about aging are more prone to physical and mental health problems as well as becoming less productive as they age. A conclusion borne out by recent research.

This can include the belief that we are somehow doomed to become less creative and, presumably, less productive with time. Granted, this point remains controversial with many physicists, computer scientists, musicians, and even artists doing their most prominent work before they hit midlife (or younger). And yet, there are prominent exceptions: J.R. Tolkien was 62 when he wrote the first volume of the Lord of the Rings, prominent physicist Sir William Crookes was 68 when he began cutting-edge research into radioactivity, while Bertrand Russells work as a writer, academician, and peace activist continued until he was almost 100.

And this is just the tip of the iceberg when you consider that people over the age of 65 represent the fastest growing age group internationally, largely due to the major medical advances of the past few decades. As I have noted in prior articles, the biological limits of our own lifespans are being radically altered and new breakthroughs may push the upper limits of human longevity even further in decades to come.

But, there is more to aging than taking stock of your grey hairs and wrinkles. Along with physical aging, there is also psychological aging, something I have already covered previously on Forbes. Also known as subjective aging, our own research has demonstrated that a lower psychological age is linked to better mental and physical health. While true physical rejuvenation isnt available (at least so far), it is also possible to make yourself feel younger, something that is an important feature of successful aging. Here are just a few suggestions you can try, and you are welcome to come up with your own suggestions:

Set ambitious longevity goals for yourself, along with fosterity the optimism you will need to achieve these goals. Our research into using deep learning techniques to predict human psychological and subjective age shows that people who are more optimistic about the future of their health and longevity, expect to live to the age that is substantially longer than average in their country, and of their health and expect to stay in good health or even improve in the next 10 years and beyond. But, what might happen if you imagined yourself living to 120 years or longer and spending those extra years being healthy and productive? Even if medical technology fails to give you those added years, the positive mindset this optimism will produce can have valuable benefits in its own right.

Science is not standing still. Huge progress was made in science and technology in the past decade alone and you should expect to live much longer and healthier. Learn as much as you can about the recent progress in aging research and tart making your own plans for an extended future. Some books you can start with include popular non-fiction books like David Sinclair's Lifespan: Why We Ageand Why We Don't Have To,

Peter Diamandis's books, The Future Is Faster Than You Think, and Bold. You can also take a look at Sergey Young's book The Science and Technology of Growing Young. These are just a few of the books already available on what is already a hot topic in science and many more will become available soon enough.

Take a psychological aging test and try to develop a longevity mindset. Go to young.ai and register for the app which can also be downloaded onto your Android or iPhone. By answering a few simple questions about your medical history and syncing information from your medical tests or your FitBit or Apple Watch, you can receive age estimates based on your different measures. This includes estimates of lifestyle age based on your response to health survey questions, mind age based on your psychological survey responses, or blood and heart age based on biomedical data. There is even a photo age feature estimating age based on face appearance alone! Use the data the app provides to develop an action plan for staying younger.

Develop friendships with younger people and avoid the retirement peer pressure that might motivate you to act your age and just settle for a comfortable retirement. As I noted in previous articles, humans are very good at adapting to radical changes, whether positive or negative. This hedonic treadmill can also cause many older adults to become complacent about their lives and correspondingly less flexible in terms of handling changes and the stress that comes with it. This means that the best way to stay younger and more creative is to avoid this age trap and take yourself out of your comfort zone. At least once in a while.

Consider taking a few courses or even going for an entire degree at a university that requires group work and constant interaction with the younger people.

Join or start a new business, preferably in health or longevity. New business opportunities are springing up daily and this is a trend that can only go upwards in the years to come. Instead of focusing on retirement, you can think of new business opportunities for yourself. Many of these opportunities will stem from the growing number of over-65s living longer and more active lives. Start exercising your own creativity and plan out a business model that will revitalize your own life.

These are just a few suggestions to consider and you can likely come up with more with the right determination and a little creativity. Remember the words of Mark Strand who said that the future is always beginning now and start planning out your own future. It will be here faster than you think.

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What Is The Most Vegan Way To Die? Welcome To A Human Compost Funeral Home – Green Queen Media

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While its not the most pleasant of subjects to discuss, most people may be surprised to learn that traditional burials are fairly toxic and harmful to the environment. As such, there has been an increase in individuals around the world looking for innovative ways to die in a manner that will be kinder to the planet. A new US company is looking to serve this market. As described in Recompose is the first full-service human-composting funeral home, providing an ecological solution for your remains when you die which involves turning you into soil.

Recompose has opened its doors to the public with its first full-service human-composting funeral home that will convert people into soil, after almost a decade of research, planning and raising funds as well as a campaign to change state law.

Founded by Katrina Spade, the first bodies were laid in Recompose starting on December 20, 2020, after a 10-year extensive journey. An architecture student at the University of Massachusetts at Amherst, Spade first looked into funeral alternatives whilst enduring a minor mortality crisis of her own. Through her research, she found that when it came to traditional burials, options were extremely limited, and most were toxic and/or expensive. Cremations tend to be carbon-intensive, while rural green burials are rare and inconvenient for urban folks.

Spade went on to explore the method of composting as a kind of soil-based cremation, leading her to complete her masters thesis on the subject. Of Dirt and Decomposition: Proposing a Place for the Urban Dead was published in 2013.

This is a very controlled process, completely driven by microbes. Its fueled by plant material and monitored in a very rigorous way

The Recompose process takes around 30 days, starting in a vessel that consists of wood chips and straw. After a few weeks, the process continues in curing bins, large boxes, one per individual, where the soil will rest and continue to exhale carbon dioxide. After the completion of this process, the family of the individual can either collect the soil or donate it to an ecological restoration project at Bells Mountain near Vancouver, Washington. So far, most families have chosen to donate the soil.

As Spade explains, each vessel is supervised for temperature and moisture content with the help of sensors that note temperature readings every 10 minutes. This ensures that the microbes inside are receiving what they require for safe and efficient composting along with rotating each vessel a few times during the process as all compost needs turning.

State regulations state that the soil must maintain a temperature of 131 degrees Fahrenheit for 72 hours that helps to safely cook away pathogens like fecal coliform and salmonella. The state also asked Recompose as well as a third party to test for those pathogens along with heavy metals, including arsenic, lead and mercury in the final soil. Furthermore, the state restricts people who have contracted certain diseases such as tuberculosis, prion infections like Creutzfeldt-Jakob disease, from undergoing natural organic reduction (NOR).

Spade adds that the process is entirely controlled. It is also completely driven by microbes. Its fueled by plant material and monitored in a very rigorous way.

In the first couple of months of Recompose, Carpenter-Boggs, a soil scientist from WSU, was present to keep a watch on the soil along with guiding Spade and her team to care for the deceased. Sade mentioned that before each body is laid into its vessel, Carpenter-Boggs requests those present to take a moment and she then recites a poem by the 13th-century Sufi poet Rumi.

Another vital component of the process is the oxygen, with air being blown into each vessel via one set of tubes and through the other set, exhaust is released passing through carbon-activated filters.

Steve Van Slyke, compliance director for the Puget Sound Clean Air Agency mentioned that the emissions and odors from NOR are expected to be minimal with respect to other operations they review. These include cremations, demolitions of asbestos-filled buildings as well as marijuana cultivation. Recomposes air permit does not show any visible emissions from the facility, nor detectible odors.

Carpenter-Boggs shared that her founder journey has involved a steep learning curve. I dont come from the funeral-care world at all and Ive learned a lot over the past five or six years.

At one point in January, eight deceased people were already inside the vessels with the process of NOR, in simple terms, human composting underway. The vessels contained remains from Ernest Ernie Brooks II, an underwater photographer to organic-farming pioneer Robert Amigo Bob Cantisano to Paulie Bontrager, a vegan, environmentalist, and nature lover from West Virginia who passed away while visiting her daughter.

Charlotte Bontrager, Paulies daughter, told the Seattle Times that she had come across a newspaper article regarding Recompose a couple of years ago. I discussed it with my mom. We talked about how cool it was and why it took so long to get a service like this. I remember her saying: If its at all possible when I die, I want to go that way. Longevity runs in my family, her uncle died a year ago at 104, and I said: Oh mom, youll be around another 30 years. Im sure itll be in place by then.

Two years after this conversation, her mother was diagnosed with a previously undetected lung condition. At that time, Bontrager wasnt thinking much about disposition choices until her mother passed. Bontrager then remembered the conversation they had and on research, discovered that Recompose was ready. My mom was a very humble, loving person and would not want any kind of spotlight. But shed be thrilled to know she was among this first group of pioneers.

As Ive learned more about Recompose, Ive found it to be a very graceful and beautiful way to go. Its the natural way, the way every living thing in history has eventually been cared for, from an apple core to a human youre not being burned up, not being pumped full of embalming chemicals and taking up space in a container. It seems like a peaceful way for the body to move on to the next phase

To get Recompose to an operational stage, another significant challenge was to push for a change in state law allowing NOR to be a legal means of disposition for human remains and this turned out successful with Governor Jay Inslee signing off on it back in May 2019. The company also raised US$6.75 million in capital, enabling them to get started with their service.

Recompose charges an all-inclusive US$5,500 fee, which includes the body pickup service that is available in King, Pierce, and Snohomish counties, the paperwork, the process as well as body transport from further away can be arranged, for an extra fee, with Recompose accepting bodies from California and the East Coast.

Bontrager added that as she learned more about Recompose, she found it to be a very graceful and beautiful way to go. Its the natural way, the way every living thing in history has eventually been cared for, from an apple core to a human youre not being burned up, not being pumped full of embalming chemicals and taking up space in a container. It seems like a peaceful way for the body to move on to the next phase.

In 2020, two other NOR competitors have come about: Herland Forest, natural-burial cemetery in Klickitat County with one vessel, also called cradle and Return Home, that is slated to open its Auburn facility in April.

With the emergence of these NOR funeral homes, more and more individuals now have the option to opt for a peaceful ecological burial that will help the planet and even in death make sure that they dont unnecessarily contribute to climate change. Lets hope human remains composting becomes more mainstream and more such burial centres open across the globe.

Lead image courtesy of Recompose.

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What Is The Most Vegan Way To Die? Welcome To A Human Compost Funeral Home - Green Queen Media

Launch a new you with the new year – Houston Chronicle

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Q: I really want next year to be the year I become as healthy as possible. Can you help me figure out a plan and schedule?

Casey R., Santa Rosa, Calif.

A: Bravo! You are planning ahead and making a public declaration of your intention to live a healthier and happier life! That shows how serious you are about achieving your goals.

By following the lifestyle adjustments suggested in my book What to Eat When and the longevity-extending tips in The Great Age Reboot (due out in 2022), you can put together a plan that is both easy to follow and loaded with great rewards.

The What to Eat When formula says eat only when the sun is up: a window of approximately 12 hours, depending on the time of year. This allows for a resting period (or fasting) and can help you break the habit of bingeing on snacks.

The guide also suggests you eat most of your food for breakfast and lunch. Aim to consume 80 percent of your daily calories before 3 p.m.

As for what you eat during these recommended times: You know the drill: plant-based, free of added sugars, no red or processed meats and no ultraprocessed foods.

Move it to lose it and gain a longer, healthier life. In The Great Age Reboot, I list steps you can take to self-engineer your fitness.

Walk 10,000 steps a day or the equivalent one minute of activity equals about 100 steps.

Get two or three sessions of strength training a week include core-strengtheners to avoid back problems down the road.

Do cardio exercise that increases your heart rate three times a week for 20 minutes. Aim for 80 percent of your age-adjusted heart rate (figure it by subtracting your age from 220 and then taking 80 percent of that).

Take 40 jumps in place a day. This increases lymphatic flow, bone density and spine health.

Q: Cancer seems to run in my family, and I want to do everything I can to help prevent it from happening to me. Can you tell me about cancer-fighting foods?

John Y., Indianapolis

A: You are right to fight! Genetic predispositions do not always mean you are going to develop whatever condition they are affiliated with. Your lifestyle choices can activate that predisposition or help squelch it! And food is a powerful tool when it comes to helping prevent cancer.

Some of our favorites are berries, lentils, kale, spinach, cauliflower, 100 percent whole grains and turmeric.

Berries: Blueberries, blackberries, raspberries and strawberries contain phytochemicals such as anthocyanins and a powerful antioxidant, pterostilbene, that reduce chronic bodywide inflammation (from obesity, red meats, added sugars, stress and poor sleep habits). Chronic inflammation ups the risk of cancer substantially. Berries also contain something called ellagic acid; laboratory studies show it has antiviral, antibacterial, antioxidant and cancer-preventive properties.

Lentils: High-fiber foods nurture good gut bacteria and may reduce the risk of colon cancer. They also help control appetite and weight being overweight is associated with an increased risk of 12 cancers.

Kale, cauliflower and spinach: Kale and other cruciferous veggies, like broccoli, cabbage and cauliflower, contain glucosinolate, which can cause tumor cells to die. Spinach contains carotenoids that may help fight cancer. It also has glycoglycerolipids certain formulations may inhibit some forms of breast cancer.

Whole grains: They contain fiber, phytochemicals and minerals that help fight cancer. One metastudy looked at the diets of 786,000 people and found that eating 7 grams of whole grains daily was associated with a 20 percent decrease in the risk of dying from cancer.

Turmeric: This tasty spice may do more than add flavor to your favorite foods. Laboratory and animal research indicates it may prevent cancer, slow its spread, make chemotherapy more effective and protect healthy cells from damage by radiation therapy. Confirmation in high-quality human trials is needed.

Contact Dr. Roizen at sharecare.com.

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Launch a new you with the new year - Houston Chronicle

Aiming to make 70 the new 50, Korify rolls out $100M longevity and mental health venture fund – FierceBiotech

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Longevity and mental health biotechs take note: Korify Capital is putting together a $100 million venture fund targeting your space and is looking to build a portfolio of 15 to 20 companies across Europe, the U.S. and Israel.

The targeted $100 million investment vehicle, which is expected to close around the middle of next year, is the first fund of Korify, the international venture arm of Swiss family office Infinitas Capital. Infinitas is active in multiple areas outside of biotech, notably real estate, but has been tracking advances in aging and mental health research and has decided the time is right to enter the space.

There are a lot of opportunities coming from academia. We have made a lot of progress in research that is now hopefully about to get translated into human applications in the coming years, and we've made great progress on the animal front and can actually do quite a lot. They're already prolonging lifespan, Robin Lauber, co-founder and chairman of Infinitas, said.

Lauber and Davide Ottolini, co-founder of Korify, each identify COVID-19 as an accelerant, both because it has increased the interest of generalist investors in longevity and because it could spur innovation in the historically moribund mental health sector. With large biopharma companies pulling back from central nervous system research, Korify sees room for smaller biotechs to build on academic progress, creating investment opportunities for the new VC fund.

RELATED: Cambrian snags $100M for 14 assets, 3-5 trials within 18 months

Theres not like a couple of dominant companies that just own the space, Lauber said. Rather, there's a lot of disruption happening at the smaller scale, in smaller biotech companies, that are very lucrative to invest in and very interesting from an investor's perspective.

Korify plans to invest in 15 to 20 such biotechs, with a focus on later-stage platform companies. That focus is evident in Korifys decision to make Cambrian Biopharma its first investment. Cambrian, which exited stealth in February, has disclosed $160 million in financing this year to advance a pipeline of 14 drug candidates designed to target biological drivers of aging.

We like their approach of being very diversified, with multiple shots on multiple targets, Lauber said. They also are very aware of the current regulatory systems that are in place. We don't really have any solid longevity biomarkers, so their strategy is set up in a way that they can get there with the current FDA framework.

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Aiming to make 70 the new 50, Korify rolls out $100M longevity and mental health venture fund - FierceBiotech

Rally Cycling rebrands as Human Powered Health – Canadian Cycling Magazine

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Building on 15 years of bringing the best of North American cycling to a global audience, Circuit Sport announced on Monday a new vision of what a racing team can stand for. The new team will be known as Human Powered Health.

Human Powered Health will be a wellness platform built to empower people to take control of their own physical and mental well-being. It will spread the message that cultivating healthier habits and living a more active lifestyle can lead to dramatic improvements in health and wellness.

Human Powered Health represents more than racing, more than athletics, said Charles Aaron, managing director and founder of Circuit Sport. Its about reminding people that they have more power over their health than they think. We want to support people, mind and body, and use our platform to inspire them to take small, simple steps towards greater health and well-being.

In previous iterations of its teams, Circuit Sport has continually gone beyond the traditional sports marketing model with health and wellness-minded campaigns like Inspired Bikes, Body Positivity, Healthy Habits, and Longevity.That will expand and evolve as the Human Powered Health platform grows into a hub for health and wellness content with its athletes as the main mouthpiece. New brand partnerships will allow the team to incorporate data analytics across sleep, nutrition, movement, and health care to support its followers on their health journey.

The team will also launch a Discord channel that will serve as a hub for fans, partners and clients interested in all things Human Powered Health. Hosted by the team and with regular appearances by professional riders, the channel will be a place to share ideas on how to live healthier lifestyles.

Human Powered Health joins the Womens WorldTour in 2022. It is the realization of a dream that began 10 years ago with the formation of the womens program. The move makes Human Powered Health the first co-ed team to send its women to the top division of the sport before its men.

Following a sensational season that included victories in the United Kingdom, Portugal, Denmark, France, and Turkey, the mens program continues in the ProTeam ranks with its sights set firmly on the WorldTour.

Rally Cyclings Sara Poidevin challenges you to create healthy habits

We couldnt take this step without the support of our partners and their shared vision for the future, added Aaron. Weve shown our ability to win bike races around the world but what sustains us is creating connections and empowering people.

Circuit Sport is currently aligning with brands that stand for something bigger than their product, a vital step to building the foundation of Human Powered Health for years to come. These brands, which will be announced in the coming weeks, share the belief that our collective health matters.

In a world navigating a pandemic, and where obesity and heart disease are at all-time highs, there has never been a more important time for each of us to invest in our health and inspire those around us to do the same. Building connections and sharing encouragement and knowledge are pivotal to empowering people to lead healthier lives.

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Viome Life Sciences Raises $54M To Accelerate Development of its mRNA Platform for Prevention, Diagnosis, and Therapeutics for Chronic Disorders,…

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BELLEVUE, Wash., Nov. 10, 2021 /PRNewswire/ --Viome Life Sciences, a mission-driven systems biology company aiming to help individuals improve their health, today announces its raise of $54M in a pre-series C convertible funding with participation from existing investors and new investors. This raise follows a $56M series B round announced in November 2019, bringing Viome's total funds raised to date to over $125M.

The latest round of funding will support expanded clinical research targeting aggressive cancers and chronic diseases, eventually leading to the development of early-stage diagnostics and therapeutics. Viome Life Sciences has partnered with leading medical clinics to research pancreatic cancer, bile cancer, breast cancer, gastrointestinal cancers, gynecological cancers, and head, neck, and shoulder cancers. The results of the clinical trials will be used to expand the ability of Viome Life Sciences' proprietary mRNA platform to screen for early-stage cancers. Viome Life Sciences is also doing clinical research using its proprietary mRNA platform to develop much-needed therapeutics targeting Alzheimer's, metabolic diseases, and mental health.

This fresh capital validates a year of tremendous growth by the health and life sciences leader and will be used to accelerate the development of Viome's mRNA platform focused on prevention, diagnosis, and therapeutics for chronic disorders, cancers, and aging. Viome Life Sciences recently hired healthcare veteran Dr. Emmanuel Hanon (former Global Head of R&D, Vaccine, at GSK) to drive this effort, and under his leadership, the company received FDA breakthrough device designation for its mRNA technology and AI platform to screen for early-stage oral cancer and throat cancer. Most recently, Viome and GSK announced a clinical validation trial and expansion of their partnership to develop new therapeutic interventions for select cancers and autoimmune diseases.

Viome has relocated its lab operations to a state-of-the-art, 25,000 sq. foot laboratory in Bothell, Washington, to support its exponential increase in consumer demand. With this relocation, Viome has been able to increase capacity by 10 times when processing samples and reduce the turnaround time for results down to 2 weeks or less. The increased capability has also supported Viome's recent expansion to 15 new countries: Australia, Belgium, Cyprus, Denmark, Estonia, Finland, Greece, Hungary, Iceland, Ireland, Italy, Poland, Portugal, Spain, and Sweden.

"The technological advancements that Viome has been able to make in the last year are nothing short of remarkable, and would not be possible without the support of our dedicated team. With each new development, we are getting that much closer to making illness optional and empowering individuals to own their own health and wellbeing," said Viome Life Sciences Founder & CEO Naveen Jain. "We are privileged to have the continued support and backing from our investors and board, and look forward to an even more dynamic year ahead."

Returning investors for this round include Khosla Ventures, West River Group, Glico, Physician Partners, and Bold Capital Group, showing their continued support and confidence in the company's growth and success. Ocgrow Ventures also participated in this round as a new investor. Harish Consul, Founder & CEO of Ocgrow Ventures will be joining as a Board Observer.

"Viome is rapidly scaling to become a global leader in the longevity space, to promote better health outcomes today and our future generations, with exceptional innovation," said Harish Consul, Founder & CEO, Ocgrow Ventures."The Viome team continues to accelerate leading AI-driven techniques to analyze gut microbiome data, which is leading to breakthrough new discoveries to help solve the root causes of so many chronic diseases to benefit all humanity."

"The future of healthcare is individual and personalized, and few companies have been driving innovation in this space as rapidly as Viome," said Vinod Khosla, Founder & CEO of Khosla Ventures. "We are proud to support Viome's efforts to find early diagnostic and potential therapeutics for chronic disorders and cancers."

"Viome has made incredible progress in a short amount of time toward solving some of the biggest healthcare problems facing our society today," said Erik Anderson Founder & CEO of West River Group. "We are proud to be able to support Viome in working toward a world without chronic diseases and cancers."

"Extending the healthy, human lifespan is a goal I share with my dear friend Naveen Jain, and his continued exploration of gene expression through Viome's proprietary mRNA technology is helping to make this a reality," said Dr. Peter Diamandis, Co-Founder of Bold Capital Partners. "Since its founding, Viome has set and achieved audacious goals and I am excited to see what Naveen is able to achieve in the next five years."

About Viome Life Sciences

Viome Life Sciences is a mission-driven systems biology company founded in 2016 totackle the epidemic of chronic diseases, cancer, and aging. To help individuals improve their health and to better understand the root of chronic diseases, Viome is strategically split into two divisions. Viome Consumer Services is focused on growing its established consumer products including tests, nutrition plans, and supplements. Viome Health Sciences is devoted to advancing its precision diagnostics and therapeutics platform. By conducting mRNA analysis at a mass scale, Viome is digitizing human biology and ultimately stopping the onset and progression of chronic diseases. Recently, Viome garnered FDA Approval for its unique mRNA technology and AI platform to detect cancers and has already successfully developed over 30 predictive models for some of the most prominent chronic diseases. For more information, visit https://www.viomelifesciences.com/

Media Contact

Kendall Donohue

viome@factorypr.com

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Living longer: This one daily habit is linked to a longer lifespan (and is free) – Times of India

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Who does not want to live a long, happy and healthy life? Unfortunately, there is no one formula that promises to increase your lifespan. However, there are some factors that can aid longevity. Developing habits that are conducive to a long life does help. As per research published in the journal Frontiers in Ageing Neurosciences, one lifestyle habit has been highlighted as the way to achieve longevity. As per the research paper titled, "Human longevity is associated with regular sleep patterns, maintenance of slow the first step towards working for longer life". Here are the three main findings of the study. - The maintenance of slow-wave sleep in the oldest-old individuals when compared to older adults.- The existence of strictly regular sleep patterns among the oldest old individuals.

- The occurrence of a favourable lipid profile in these individuals.

The signature of sleep ECG in the brain of oldest-old individuals was also described. These findings support the role of sleep and lipid metabolism control in the maintenance of longevity in humans.

For the unversed, a lipid profile is a blood test that measures the amount of cholesterol and triglyceride in the blood. High levels of triglyceride in the blood can increase one's risk of heart disease.

Thus, regular sleep can reduce the risk of heart disease, which is a major killer worldwide.

Here are some simple steps to sleep better:

Make a sleep schedule and stick to itGo to bed and wake up at the same time every day. Plan to sleep for at least 7-8 hours each day.

Say no to caffeine and nicotine before bedtimeNicotine, caffeine and alcohol can disrupt your sleep. Also, avoid heavy and spicy foods to avoid indigestion and get a peaceful sleep.

Create a restful environmentDark, cool and quiet places without a buzz of electronic activity help one fall asleep. Do not put a TV in your bedroom.

Say NO to day-time naps

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Living longer: This one daily habit is linked to a longer lifespan (and is free) - Times of India

Here’s why closing the skills gap is key to digitalization – World Economic Forum

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According to the engineer and entrepreneur Peter Diamandis, in the next ten years we are likely to experience as much technological change as in the past 100 years. The technologies of the fourth industrial revolution are set to become far more widespread and accessible. They will also converge in ways that create new value.

Companies and governments around the world are developing modernization strategies to use these new technologies, which include artificial intelligence, cloud-based services and internet of things. The success of any organization's digital transformation, however, is not entirely dependent on state-of-the-art technology; it depends on human capital, too. This is one aspect of technological change management that persistently gets forgotten.

Human security as an after-thought

Security is often an after-thought in technological design and implementation, despite the grave threat cyber attacks pose to business continuity, service delivery and intellectual property protection. With the rise of more advanced encryption and security protocols, malicious actors have increasingly sought to compromise the weakest link the human beings who interact with these systems. It is no surprise that ransomware attacks have increased threefold in just the first half of 2021. The cybersecurity skills gap becomes more acute as new technologies create more complex digital supply chains. Here are some key ways to increase human security:

According to the 2020 Forums Future of Jobs report, skills gaps in the local labour market and the inability to attract the right talent remain among the leading barriers to the adoption of new technologies. Building a future-proof workforce will depend on properly defining the skills needed, and providing opportunities for people to train. The cybersecurity sector needs a diverse range of experience, expertise and thinking to tackle the enormous challenges ahead.

Skills gaps and the inability to attract the right talent remain among the leading barriers to the adoption of new technologies.

Image: World Economic Forum

While science and technology skills remain an important foundation, analytical skills are equally important in dealing with big data. Marketing and communication skills are also needed to work with business stakeholders, as are legal skills, when it comes to interpreting complex regulatory policies.

Solving the workforce challenge will require business leaders to rethink and define effective systems for upskilling individuals and capabilities. Building this workforce of the future will rely on partnerships between businesses, government agencies and academic institutions.

2. Security awareness as a core element of workplace upskilling

Today some new graduates are already finding that they need to upskill even at the beginning of their first job. Many companies have understood that the longevity of higher education is decreasing, and that in order to maintain relevant expertise in their workforce, they need to be proactive about upskilling. The American telecommunications company AT&T, for example, has dedicated $1 billion to upskilling and educating its workforce.

What is still lacking, however, is a prioritization of cybersecurity awareness. People outside the IT and cybersecurity functions need training in this area in order to make better decisions on the design, the operation and oversight of digital infrastructure. As organisations adopt new technology, software and digital processes they need a cybersecurity education plan to keep employees informed and aware of any dangers.

The World Economic Forum's Centre for Cybersecurity is leading the global response to address systemic cybersecurity challenges and improve digital trust. We are an independent and impartial global platform committed to fostering international dialogues and collaboration on cybersecurity in the public and private sectors. We bridge the gap between cybersecurity experts and decision makers at the highest levels to reinforce the importance of cybersecurity as a key strategic priority.

Our community has three key priorities:

Strengthening Global Cooperation - to increase global cooperation between public and private stakeholders to foster a collective response to cybercrime and address key security challenges posed by barriers to cooperation.

Understanding Future Networks and Technology - to identify cybersecurity challenges and opportunities posed by new technologies, and accelerate forward-looking solutions.

Building Cyber Resilience - to develop and amplify scalable solutions to accelerate the adoption of best practices and increase cyber resilience.

Initiatives include building a partnership to address the global cyber enforcement gap through improving the efficiency and effectiveness of public-private collaboration in cybercrime investigations; equipping business decision makers and cybersecurity leaders with the tools necessary to govern cyber risks, protect business assets and investments from the impact of cyber-attacks; and enhancing cyber resilience across key industry sectors such as electricity, aviation and oil & gas. We also promote mission aligned initiatives championed by our partner organizations.

The Forum is also a signatory of the Paris Call for Trust and Security in Cyberspace which aims to ensure digital peace and security which encourages signatories to protect individuals and infrastructure, to protect intellectual property, to cooperate in defense, and refrain from doing harm.

For more information, please contact us.

3. Hire personnel with a combination of technology expertise and mentoring capability

It is not enough to have a digital transformation plan that meets deadlines and budgets. It needs to be implemented in a way that is compatible to an organizations culture. People are the most important assets in an organization, and as such it is important to consider where they sit in the different technology adopter categories.

People are the most important assets in an organization, and it is important to consider where they sit in the different technology adopter categories.

Image: http://blog.leanmonitor.com/early-adopters-allies-launching-product/

It is not uncommon for some people to resist technological change in their personal life or at work. There should be designated staff to facilitate technology education, and to offer coaching to staff during any technological transition. These people should be effective communicators who are versed in technological change management, technology and risk management. They need the right personality to support employees as they grapple with new technology and new risks.

The unprecedented growth of new technologies reminds us that our digital systems are an intractable part of the way business is done in the 21st century. These digital systems must include not only technical cybersecurity measures, but also a thoughtful analysis of the workforces skills and how it contributes to a sustainable culture of security.

The views expressed in this article are those of the author alone and not the World Economic Forum.

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Here's why closing the skills gap is key to digitalization - World Economic Forum

Secret Tricks for Convincing Yourself to Exercise, Say Experts | Eat This Not That – Eat This, Not That

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If you require a lot of motivation to get yourself to exercise, take comfort in this fact: You're not actually lazy. At least that's according to Harvard biologist Daniel Lieberman, Ph.D., author of Exercised: Why Something We Never Evolved to Do Is Healthy and Rewarding. He says you're totally normal and behaving the way that human beings naturally evolved to behave.

"We evolved to be physically active, but exercise is a special kind of physical activity," he explained to The Harvard Gazette. "It's voluntary physical activity for the sake of health and fitness. Until recently, nobody did that. In fact, it would be a kind of a crazy thing to do because if you're a very active hunter-gatherer, for example, or a subsistence farmer, it wouldn't make sense to spend any extra energy going for a needless five-mile jog in the morning. It doesn't help you."

Fast forward to 2021, and you need exerciseand you need to fight your instincts not to. So the first order of business is to be kinder to yourself, and know that you're inherently hardwired to avoid it. The next thing to do? Follow these simple tricks for convincing yourself to hit the gym. Trust us: Your body will thank you later. And for more great exercise advice, don't miss the Secret Side Effects of Lifting Weights for the First Time, Says Science.

Ticking off many achievable targets keeps people motivated, says Mark Davis, a researcher at the University of Bristol, in England. In a study of 78 adults, Davis gave half the subjects a modest fitness goal (walk 2,500 steps daily) and the others an ambitious goal (10,000 steps). Result: The participants with the easier target were 27 percent more likely to keep exercising. And if you love to walk, make sure you know about The Secret Cult Walking Shoe That Walkers Everywhere Are Totally Obsessed With.

"Your training partner needs to be someone who will hold you accountable," says Jack Raglin, Ph.D., a professor of kinesiology at Indiana University. An old study by Raglin found that 92 percent of couples who went to the gym together continued to do so after a year. By contrast, couples who worked out separately had a 50 percent dropout rate. And for more amazing exercise advice, don't miss the Unexpected Side Effects of Working Out in the Morning, Say Experts.

"Eliminating boredom is one of the most important factors for maintaining the longevity of a fitness program," says Chris Jordan, C.S.C.S. A study of 61 people at the University of Florida found that people who varied their workouts were 15 percent more likely to exercise regularly than those who stuck to one workout.

The music will help you exercise longer and more intensely without even realizing it. Anew study just released by the University of Edinburgh reports that when it comes to going for a run or jog, music helps you overcome mental adversity so much more easily. Read more about this study here.

Research conducted at Springfield College in Massachusetts found that people who cooled down for 5 minutes at the end of a bike workout rated it easier than when they did a workout of equal intensity that didn't include a cool down. It suggests that if the last thing you do is pleasant, you're more apt to repeat your workout. And if you're inspired to lift now, make sure you're aware of The Single Greatest Weightlifting Move for Shedding Pounds, Says Science.

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Turtles Can Live From the Victorian Era up to Present; Reason Behind the Longevity of Turtles Explained – Science Times

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In 2019, Guinness World Recordsawarded the "world's oldest animal on land" to a certain creature located in South Atlantic. The award was given to Jonathan, an enormous tortoise that had been living on the island of St. Helena for almost two centuries now.

Guinness World Records selected Jonathan as the winner of the title due to the tortoise being born during Queen Victoria's era way back in the 1830s. Jonathan was 80 years old when the famous ship Titanic sank, and by the time it got the world record, the tortoise was at its 187 years of age.

(Photo: Brady Knoll from Pexels)

Jonathan is an example of a creature under the family of turtles that had been recorded with staggering longevity. According to Florida SouthWestern State College biology expert and turtle ecologist Jordan Donini in a Live Sciencereport, sea turtles have a life span of 50 to 100 years, while box turtles are more enduring and can live beyond a century. Donini added that the maximum life span of most sea turtle species is still uncovered.

Turtles have the best longevity among the animal kingdom due to numerous biological and evolutionary explanations. In the Live Science interview, Arkansas State University reptile expert and physiology professor Lori Neuman-Lee said that in terms of evolution, the turtles have simply adapted to the common food chain activity that was being conducted for many years.

Some animals like snakes and raccoons are fond of turtle eggs, and the only way to escape this chain is for the turtles to pass down their genes. Along with procreation, turtles learned how to live longer than they do and breed consecutively.

The turtles' longevity in biological explanation, on the other hand, is much more complicated than their straightforward evolutionary history. According to Neuman-Lee, turtles are also composed of telomeres, a genetic material that houses genomes by acting as a protective cap on DNA's end strands or chromosomes.

ALSO READ: Congenital Heart Disease and Autism in Children Possibly Caused by Sperm Mutation in Older Men

The function of telomeres is to protect the chromosomes in case of cell division. However, these protective caps get smaller and degrade over time, creating an effect on the chromosomes and eventually halting DNA replication. What is devastating about this genetic process is that when DNA stops replicating, tumors and cell anomalies develop.

Telomeres in turtles, however, have a lower rate of decay. Compared to the protective caps in human chromosomes, the telomeres of turtles do not shorten quickly and can deflect any significant changes brought by a negative effect during DNA replication.

The turtles are not yet fully examined, and other factors that could explain their longevity are still a puzzle for experts. However, some scientific theories have been formulated regarding the turtle's long life. Through the series of experiments and observations, the scientists are able to build a hypothesis that will possibly help us understand the longevity of turtles in the future.

Among the investigations on the near-immortality feature of turtles is the recently published article in the journal arXiv, titled "Concurrent Evolution of Anti-Aging Gene Duplications and Cellular Phenotypes in Long-Lived Turtles."

RELATED ARTICLE: Plant-Animal Mutualism: Coevolution of Fruit Bats and Pepper Plants Linked to Biological Scent Sensory Ability

Check out more news and information on Biologyin Science Times.

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REVIEW: ‘The Dig’ is captivating, beautiful exploration of past The Daily Free Press – Daily Free Press

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Combining the directorial skills of Simon Stone, the screenplay adaptation by Moira Buffini and the cinematography of Mike Eley, The Dig portrays a dynamic, true story intertwining themes of history and modern existential longing with dramatic scenes concerning life, death, love and family.

The Netflix film, released Jan. 29, is an adaptation of John Prestons 2007 novel of the same name and is based on a true story. Taking place in the rustic countryside of Suffolk, England on the eve of World War II, self-taught archaeologist Basil Brown, played by Ralph Fiennes, embarks on a dig to uncover whats believed to be ancient Anglo-Saxon ruins potentially dating as far back as the Vikings or further.

The site lies on the vast estate owned by Edith Pretty, played by 2013s The Great Gatsby star Carey Mulligan. Pretty is a widow left with one son and a dream to dig up three large, grassy, hill-like mounds located in the fields. Though the archaeologist is unconvinced theres anything significant to be found, attempted grave robberies have convinced Pretty theres something extremely valuable hidden within.

Brown, a local archaeologist with the Ipswich Museum, leads the Sutton Hoo excavation, with Peggy Piggott, played by Lily James. Hes portrayed as a modest working man with vast knowledge of the land. His soil expertise is what leads Pretty to hire him in the first place.

Given the politics of the time period, the dig site is seen as an area of national interest as Britain was preparing to protect the countrys ancient ruins from German air raids.

The story shifts toward a more intimate focus, concerned with family and belonging, when Prettys young son Robert, played by Archie Barnes, grows increasingly fond of Brown. The two are portrayed almost as father and son, bringing the narrative closer to one of community rather than national glory.

The Dig captures a unique perspective of existentialism, with the story taking place during Britains mobilization before wartime. It keeps audiences reflecting on the significance of human legacy, wondering what will be left of us after we are gone.

As the characters on screen are forced to come to terms with their own mortality in an age of destruction and uncertainty, we get a better understanding of the significance of these ancient runes that are still standing a testament of humanitys longevity.

Aside from matters of historical and ancestral significance, The Dig is a nod to the struggles that affect ordinary people of today, with overtones of love, lust and heartbreak.

What keeps viewers satisfied throughout the film is the unchanging and breathtaking scenery of the Suffolk countryside. Eley yields cinematographic mastery by capturing the lush wheat fields of eastern England, combined with enticing pan shots of the site to emphasize how massive this project is, yet also how seemingly small of a role it plays in the full history of the nation.

Stone keeps audiences holding their breaths by turning a story of national history into a heartfelt drama that so accurately touches on struggles that afflict people of all backgrounds.

Its worth mentioning the film has received some criticism for sexist portrayal of characters, for ageism despite the whimsical setting and for fictionalizing some of the truth.

Be that as it may, it was worth the watch.

At surface level, The Dig seems like a story of historical drama, but it takes audiences into deep-cutting, emotionally luring instances of love, loss, triumph and human connection.

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REVIEW: 'The Dig' is captivating, beautiful exploration of past The Daily Free Press - Daily Free Press

Precision Medicine Software Market Size 2021 Global Analysis, Trends, Forecast up to 2028 – The Market Writeuo – The Market Writeuo

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New Jersey, United States,-Verified Market Research recently released a new report titled Precision Medicine Software MarketSize Report, Growth and Forecast 2021-2028, Breakdown Data by Company, Key Regions, Types and Applications. The report has been compiled using primary and secondary research methodology that will provide a precise and precise understanding of the Precision Medicine Software market. Analysts used a top-down and bottom-up approach to assess the segments and properly assess their impact on the Precision Medicine Software market. The report offers a market overview which briefly describes the market situation and major segments. It also mentions the best players represented in the Precision Medicine Software market.

The 2021 report offers an in-depth analysis of each sector of this Precision Medicine Software industry. Fill in historical Precision Medicine Software data according to customer requirements. It offers Precision Medicine Software market research globally and locally. The detailed segment and manufacturer information of Precision Medicine Software helps guide future benefits and make important decisions for the growth of Precision Medicine Software.

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2bPrecise LLC, Syapse PierianDx Fabric Genomics, SOPHiA GENETICS SA, N-of-One Foundation Medicine Human Longevity Sunquest Information Systems Inc., Translational Software, Inc.

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About Us: Verified Market Research

Verified Market Research is a leading Global Research and Consulting firm that has been providing advanced analytical research solutions, custom consulting and in-depth data analysis for 10+ years to individuals and companies alike that are looking for accurate, reliable and up to date research data and technical consulting. We offer insights into strategic and growth analyses, Data necessary to achieve corporate goals and help make critical revenue decisions.

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We, at Verified Market Research, assist in understanding holistic market indicating factors and most current and future market trends. Our analysts, with their high expertise in data gathering and governance, utilize industry techniques to collate and examine data at all stages. They are trained to combine modern data collection techniques, superior research methodology, subject expertise and years of collective experience to produce informative and accurate research.

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In Cleveland, Unsheltered Homelessness Decreased In 2020. Can It Continue? – ideastream

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By Conor Morris, for theNortheast Ohio Solutions Journalism Collaborative

There was one bright spot in the darkness of the coronavirus pandemic in Cleveland last year: Fewer people were homeless and living on the streets.

Chris Knestrick, executive director of the Northeast Ohio Coalition for the Homeless (NEOCH), said his group estimates that there was a roughly 30 percent decrease in the number of unsheltered people experiencing homelessness in Cleveland in the second half of 2020, a drop from an average of 124 people to 85. Unsheltered means people living outside, in tents or on the street and not in homeless shelters.

While there were still hundreds of people in Clevelands homeless shelters, thats still a positive statistic, Knestrick said.

To achieve the reduction, a lot of relatively unprecedented things had to happen in Cleveland, Knestrick said: A large amount of rental assistance to prevent people from becoming homeless; a moratorium on evictions locally and later federally; and money to support putting homeless and unsheltered people into five hotels.

Northeast Ohio Coalition for the Homeless (NEOCH)

Before most of these measures were in place, in the first half of 2020, Cleveland saw a slight increase in the average number of people experiencing homelessness living outside the shelter system, 17 percent higher compared to the first half of 2019. That number dropped in the second half of 2020, after the pandemic-related rental assistance began and more hotels were brought online, Knestrick said.

The decrease happened despite expectations that the number of unsheltered homeless people would increase due to the pandemic, Knestrick said. While none of the efforts mentioned were perfect solutions to homelessness, they did help, he said.

This feat begs the question: Can Cleveland government, nonprofits and volunteers keep up this support into 2021 and beyond? Elsewhere, some cities, like Austin, Texas, have permanently purchased hotels to continue these kinds of initiatives.

The Northeast Ohio Solutions Journalism Collaborative asked Knestrick about the work done in 2020 to keep people experiencing homelessness off the streets in Cleveland, and the potential longevity of these measures. [Editors Note: The Cleveland Street Chronicle, which is supported by NEOCH, is a member of NEOSOJO.]

Some people might not know what the homeless situation looks like in Cleveland generally speaking, so, where are people living and has that changed much during the pandemic?

More and more people were having a housing crisis in our community and seeking emergency shelter. Before the pandemic, our community had a strong response to homelessness. But it was mostly designated toward large shelters in our community.

When the pandemic hit in March, we quickly realized that congregate living situations like large shelters are a huge risk for our people, who oftentimes already have preexisting conditions and suffer from many of the things that make COVID-19 a deadly virus for people.

Through leadership, through the continuum of care [body of agencies responding to homelessness] and also with great leadership from the City of Cleveland and Cuyahoga County, we quickly began to place people into hotels to de-congregate the shelters [so that they] could practice safe distancing in some way.

One of the statistics I had seen previously was there was a 30 percent decrease in unsheltered homelessness in Cleveland during 2020. Can you just walk me through how that happened?

The 30 percent is an estimate, its hard to have exact data on real human beings in our community. People come and go out of homelessness at any given time.

Thats something were always checking because we need to make sure we know where people are to provide [them] with supplies to survive the winter and to really encourage them to go into shelter and to move towards permanent housing.

I think one of the lucky things that we saw, as CARES (Act) money came in and we were able to afford non-congregate living settings and took advantage of that, we saw people much more apt to engage in our services.

As people are working just to survive outside, theyre out there hustling and doing their thing and its a lot harder to engage and contact people. I think hotels offered us an opportunity to build really deep relationships with people and to accompany them into a housing process in a way that was new to us.

Weve also [permanently] housed, since March, over 70 people in our community [who were unsheltered]. We were able to accompany them as they worked to figure out how to end their housing crisis or homelessness [and get into stable housing, like rentals].

Were there any other lessons learned from Clevelands response to homelessness from 2020? Can any of this be replicated into the future?

I think if we look at the eviction moratorium that was issued by our local government, evictions were down and I think they continued to be down after a federal moratorium on eviction happened. In our minds, what we learned is, how do we give tenants more rights and opportunities to prevent eviction? [We had] a robust housing assistance program that was put in place to really prevent homelessness this year. I think it begs the question, can we really see that robust housing assistance, coupled with policies that protect tenants [continued]?

One of those things that we [saw this year] is a really deep conversation around homeless prevention, and thats a new thing in our community. Before COVID-19 and the pandemic, homeless prevention was not possible because there was no funding for it. I think its really about how we are going to move forward and build policies and gain resources to help prevent people from entering into homelessness?

Previously, with unemployment we did expect a large boom in the homeless population and that has not happened. Were far from done with the pandemic. But I think weve realized that robust homeless prevention in our community is really needed and a really important resource that we havent had in the past.

Why hasnt that kind of funding available for homeless prevention in the past? Is it a federal problem, a local problem, a state problem?

Its all three. We have talked a lot with our local officials over time about the need for, for example, a flexible, shallow [small] housing subsidy in our community for folks who are housing insecure [which has not happened yet].

I think it comes down to having a living wage. A mother of two making minimum wage in our community would have to work 75 hours a week to afford a two-bedroom in our community [according to RentCafe.com, average rent is $1,134 per month in Cleveland], which is an impossible feat. So we know that housing assistance and homeless prevention is needed but weve never seemed to quite prioritize it like we have during the pandemic.

I really think its a question of political will.

Is there enough funding to continue running the five hotels for the homeless for the rest of 2021?

I dont think the funding has been appropriated for all of the year. We definitely know that we can get through all of the winter season using hotels. Were looking at whats happening in Washington during this time.

I think were super excited that Marsha Fudge has been selected to be the [U.S. Department of Housing and Urban Development] secretary. I think it really depends on if a CARES Act [stimulus] is going to be continued to be moved and allocated throughout the year for us to continue to do it. Will our local government continue to prioritize it? I think they will, they have. But I think the question we really need to think about is, we dont want to go back to normal.

We want to come back to a place thats better than where we left it. Because where we left it was shelters were full to capacity everywhere and more and more people were experiencing homelessness. Trying to get to a place where we come out of the pandemic better and more equipped to get more people into housing is the way to go.

If anyone wants to help out people who are homeless in our community, what should they do?

First and foremost, treat people with dignity all the time. Whether theyre homeless or whether theyre your neighbors or the people you live with.

The person thats downtown in Public Square is a member of our community as much as a person who lives in one of the condos or big buildings down there. Continuing to engage and get to know them and learn their stories is really what I encourage everyone to do.

If youre interested in supporting or learning more about our work, you can go to our website, its NEOCH.org. I think were always looking for support in many different ways.

Conor Morris is a corps member withReport for America. You can email him atcmorris@advance-ohio.com, or find him onTwitter. This story is sponsored by theNortheast Ohio Solutions Journalism Collaborative, which is composed of 20-plus Northeast Ohio news outlets, including ideastream

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Who wants to live for ever? – Ageing can be curedand, in part, it soon will be | Books & arts – The Economist

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That is Andrew Steeles thesis in Ageless

Feb 6th 2021

Ageless. By Andrew Steele. Doubleday; 352 pages; $29. Bloomsbury; 20

OLD AGE is a massacre, wrote Philip Roth, long before the pandemic underscored its hazards. Even those who count as young must often watch the ineluctable drift of loved ones into decrepitude. Andrew Steele has a hopeful message for all those facing this prospect (ie, everyone). Old age neednt be a massacre; in fact, old age neednt even be old.

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Mr Steeles thesis in Ageless is that ageing can be curedand, at least in part, that it very soon will be. The giant tortoises of the Galapagos Islands show no age-related decline, in some ways seeming as youthful at 170 as at 30. Mr Steele thinks this phenomenon, known as negligible senescence, is within humanitys grasp, too.

Whether or not readers are persuaded that ageless humans could ever be more than a theoretical possibilityand it is a stretchthis book will convince them that discounting the theoretical possibility altogether is based on nothing but prejudice. Western art may have something to do with it, bristling as it is with morality tales about the folly of wanting to turn back the clock; but there is actually no good reason to assume an upper limit to longevity, or that ageing must come with decline. And there is quite a lot of evidence to the contrary. Without the rich worlds denizens really noticing, a life that ends after the biblical three score years and ten has already come to seem a life cut short; instead, 90 is now seen as a good innings.

This prejudice held back the field of biogerontology for a very long time, but in the past few decades some scientists have cast it aside. This has enabled them to see that the real folly lies in the attempt to cure the diseases of old age one by one, rather than tackling their underlying causeageing itself. Now they are trying to understand that process in all its extraordinary complexity, and to intervene much earlier.

They have many tools at their disposal, and Mr Steele, who has a background in computational biology, evaluates them expertly and with verve. They range from drugs that mimic the life-extending effects of dietary restriction to gene-editing tools such as CRISPR and computer models that simulate whole biological systems. Such models may eventually prove the key that unlocks the inner Methuselah in everyone, by revealing both the limits to these systems and their redundancies: what can be tweaked, and what had best be left alone.

Temporarilyand with a bitter ironycovid-19 has slammed the brakes on this burgeoning area of research. But Mr Steele thinks its first dividends will emerge within a couple of years, perhaps in the form of senolytic drugs that clear the accumulating cellular detritus of a long life. He makes the valid point that if, for every year of scientific endeavour, a year could be added to the average human lifespan, old age would recede into the future at the same rate as todays population approached it. That would itself be quite a milestone on the road to negligible senescence.

This interim goal is easily within reach, he claims. Many scientists agreeand are among those who have chosen to take experimental anti-ageing drugs. For some of these treatments they have calculated that the risks are small, compared with the potential benefits. The true sign that a scientific revolution is in the offing is that the scientists themselves have bought into it. Whether that revolution is desirable is a different question, which it may fall to a new generation of artists to answer.

This article appeared in the Books & arts section of the print edition under the headline "Who wants to live for ever?"

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Who wants to live for ever? - Ageing can be curedand, in part, it soon will be | Books & arts - The Economist

Around Town: UC Irvine to host a virtual celebration Monday to ring in the Year of the Ox – Los Angeles Times

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The Lunar New Year will be welcomed Monday afternoon when UC Irvine hosts a special virtual celebration of the Year of the Ox.

The festivities are free and open to the public and are expected to include a dragon dance and feeding of the lion in addition to performances from artist Abigail Washburn and world-famous guzheng musician Wu Fei.

There will also be a virtual wishing tree and guests will be able to make a wish for prosperity, happiness and longevity by writing a wish on a red wishing card and taking a selfie with it. Wishing cards and more details on the event can be read at humanities.uci.edu.

Registration is required to attend and the event will begin at 4:30 p.m. on Feb. 8.

The Lunar New Year is on Feb. 12.

Laguna Beach hires recruiting firm for city manager searchLaguna Beach has begun the recruiting process in search of the seaside communitys next city manager.

John Pietig, the presiding city manager of Laguna Beach, announced the first week of January that he plans to retire in June. His service to the city has spanned 20 years.

The Laguna Beach City Council, which makes the appointment for the position of city manager, has hired the recruiting firm Bob Murray & Associates to carry out a search for candidates to serve as the citys top executive. City officials said the estimated cost for the executive recruiting firms services is less than $30,000.

This is one of the most important positions in the city, and hiring the recruiting firm will allow us to thoroughly evaluate both internal and external candidates for the City Manager position, Laguna Beach Mayor Bob Whalen said in a statement.

Pietig began his run with Laguna as assistant city manager, and he has served as city manager for the last decade. According to Whalen, the City Council aims to name his replacement in May.

Laguna Beach Dems to host OC Supervisor race talk Attorney Ashleigh Aitken will address the 6:30 p.m. Feb. 10 meeting of the Laguna Beach Democratic Club, a Zoom meeting that is open to the public. The events topic is the upcoming Orange County Board of Supervisors election, what role the board plays in running the county and how it allocates its $7.5 billion budget.

We should all be informed about and weigh in on how our tax dollars are being allocated by the Board of Supervisors, Gwen McNallan, president of the club, stated in a news release.

To learn more about the club, or to register for Wednesdays Zoom meeting, visit thelbdems.com.

OC emergency rental assistance program accepting applicationsThe County of Orange is accepting applications through the month of February for an Emergency Rental Assistance program for eligible renters struggling with unpaid rent or utilities bills during the COVID-19 pandemic.

Launched this week and funded by a $65.5 million allocation from the U.S. Department of Treasury, the program aims to provide financial assistance to those whose combined household income is at or below 80% of the countys average median income.

In Orange County, the median income is approximately $71,750 for an individual, $82,000 for a two-member household, $92,250 for three people and $102,450 for a four-person household. For more information on household size, visit era.211oc.org.

Residents of Anaheim, Santa Ana and Irvine may not participate in Orange Countys assistance program, as those cities have population sizes over 200,000 and maintain their own local city programs, according to a release issued last week by the Orange County Health Care Agency.

The Emergency Rental Assistance program does not apply to homeowners with past-due mortgage payments, utilities or energy costs. Funds may only be granted to renters.

Applicants will need to provide a photo ID, a copy of their lease agreement, proof of income affected by COVID-19, such as an unemployment letter or a letter from an employment detailing reduced hours or pay and proof of unpaid rent or utilities, such as documentation from a landlord or utility company stating an amount owed or overdue.

To learn how to apply, call 2-1-1 to receive assistance in multiple languages, visit era.211oc.org or text ERA to 898211.

Marine Corps Scholarship Foundation accepting applications through March 2A range of college scholarships are available to children or stepchildren of a Marine or Navy corpsmen, chaplain or religious programs specialist attached to a Marine unit who have a cumulative grade point average of 2.0 (on an unweighted 4.0 scale) and whose family has an adjusted gross income of $106,000 or less for 2021-22.

Scholarships are available for those pursuing an associates or bachelors degree, attending or planning to attend a college or career training school listed on the National Center for Education Statistics College Navigator website during the 2021-22 academic year.

Career and technical education scholarships are also available for students planning to attend a non-degree certificate program or vocational training 12 months or less at a community college or private career school listed on the College Navigator website.

Applications may be submitted through March 2. For more information, visit mcsf.org/apply.

Laguna Beach Festival of Arts 2021 grant applications due March 5Nonprofit organizations with programs promoting fine arts in and around the city of Laguna Beach are welcome to apply for a series of art grants through the Festival of Arts Foundation beginning Feb. 8.

The Foundation, established in 1989 to preserve and promote fine arts and other artistic endeavors in the area, will be accepting applications through March 5.

The FOA Foundation is proud to be able to assist local non-profit art organizations during these challenging times, Foundation President Bob Earl said in a statement. We hope that these funds will help to continue the programs that educate our community on the importance of art and cultural experiences.

Applications can be submitted online at foapom.com/grants. For information on eligibility, grant awards and the application process, contact Bob Earl at (949) 494-4132.

Laguna Beach school board appoints Michael Conlon to assistant superintendentThe Laguna Beach Unified School District has named Michael Conlon its assistant superintendent of human resources and public communications, according to district officials.

Conlon, who was serving as the director of human resources for the district, was appointed to the role at the board meeting on Jan. 28, at which the board considered reorganizing into a format with three assistant superintendents.

A statement from the district said that the decision would not result in an increase in staff. Jeff Dixon is the assistant superintendent of business services, and the district plans to hire an assistant superintendent of instructional services.

Michael [Conlon] has continued to demonstrate his focus on continuous improvement for himself and our community, District Supt. Jason Viloria said in the release. He is committed to developing positive relationships with staff and problem-solving conflicts when they occur. He has proven to be an effective human resources leader and administrator whose work is characterized by a genuine concern for the entire school community.

Back Bay products Mo Kenney, Tanner Pulice earn mens water polo honorsNewport Harbor High alumnus Mo Kenney earned Mountain Pacific Sports Federation Player of the Week honors this week, while Corona del Mar High product Tanner Pulice was named the MPSF Newcomer of the Week.

Both Kenney and Pulice are freshmen for the UCLA mens water polo team.

In his collegiate debut, Kenney scored a game-high five goals on Jan. 30 to lead the No. 2-ranked Bruins to a 15-9 home win over No. 5 Pepperdine. Four of the goals were even strength, and one came on the power play. He needed just six shots to score the five goals.

Pulice had two goals and two assists in the victory, also winning a sprint and drawing an exclusion.

Cal senior football player Michael Saffell, an Edison High alumnus, has been named the Pac-12 Football Scholar Athlete of the Year.

Saffell, a center, started on the offensive line for the Golden Bears each of the last three years, earning honorable mention All-Pac-12 honors in 2020. He began his career at guard before moving to center as a junior.

Due to COVID-19, he is eligible for a fifth year of competition, and he has opted to return in 2021.

Saffell earned his bachelors degree from Cals Haas School of Business in three-and-a-half years, graduating in December with a 3.62 undergraduate GPA. He was accepted into the universitys Master of Information and Data Science program, which he began in January.

Orange County SC shirt sales to benefit OC Educational Arts AcademyThe Orange County Soccer Club has started the JuntosMsFuertes campaign, hoping to combine the communitys passion for soccer and the arts to support diverse nonprofit organizations.

A custom shirt has been created in collaboration with a local artist, and all net proceeds from its sale will go to the Orange County Educational Arts Academy.

Located in Santa Ana, the institution serves about 630 students, ranging from transitional kindergarten to eighth grade.

Hugo Cesar Chavarria was the Southern Californian artist called upon to create the design for the shirt, which depicts action in an Orange County Soccer Club game with landmarks like the Santa Ana Water Tower and the Great Park Balloon in Irvine in the background.

The shirts are limited edition and will be on sale through February. The cost is $20 per shirt, and they can be purchased at the following link: bit.ly/OCSCDASH.

Sage Hill School accepting applications for 2021-22 school year through Feb. 15Sage Hill School, a nonprofit, non-denominational independent high school is accepting applications for students in grades 9-12 for the 2021-22 school year through Feb. 15.

Having reopened its doors to students in September five days a week, Sage Hill offered classes virtually or in-person during the 2020-21 school year.

For more information on programs, or to apply online, visit sagehillschool.org and click on the Admission tab. For all candidates who apply by the Feb. 15 deadline, first-round decisions will be announced the last week of February.

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Around Town: UC Irvine to host a virtual celebration Monday to ring in the Year of the Ox - Los Angeles Times

Landmark Review Calls for Nature to Be at the Center of Economic Decision-Making – Sustainable Brands

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The UK Government commissioned an independent, global Review on the Economics ofBiodiversity in Spring 2019. The report urges policymakers to start valuing ecosystems and says GDP encourages unsustainable growth.

Businesses and governments around the world will have to rethink economic growthas a measure of success if they want to make good on pledges to stop thedestruction of the natural world, according to a UK government-backed reportpublished today.

Commissioned by the UK government in 2019, the Review on the Economics of Biodiversity led by University of Cambridge economistProfessor Sir ParthaDasgupta lays out keyrecommendations for reversing manmade declines in biodiversity that areundermining the productivity, resilience and adaptability of our natural. Itwarns that this historic decline has placed economies and livelihoods at risk.

The study supports the assertions that environmental groups have been making fordecades that humanity has mismanaged its natural assets, and our demands onnature now far exceed its capacity to supply resources and vital services. TheReview calls for the expanding and improvement of protected areas, increasedinvestment into nature-based solutions, the creation or improvement of policiesto eliminate damaging consumption of natural assets. and the incorporation ofnatural capitalaccountingand proper valuation of ecosystemservicesinto all national accounting systems.

This year is critical in determining whether we can stop and reverse theconcerning trend of fast-declining biodiversity, said UK Prime Minister BorisJohnson. I welcome Professor Dasguptas Review, which makes clear thatprotecting and enhancing nature needs more than good intentions it requiresconcerted, co-ordinated action.

Join us as JUST Capital's Lorraine Wilson and author Michelle Holliday discuss viable pathways to stakeholder capitalism, justice and regeneration at our next virtual event, SB'21 Trend Watching February 23.

As co-host of COP26 and president of this yearsG7, we are going to make sure the natural world stays right at the top ofthe global agenda. And we will be leading by example here at home as we buildback greener from the pandemic through my Ten-PointPlan.

The Review also calls for ending the use of Gross Domestic Product (GDP)infavor of different metrics that would embed natural resources into todayseconomic accounting, as part of a shift towards a more accurate and inclusivemeasure of wealth.

Truly sustainable economic growth and development means recognising that ourlong-term prosperity relies on rebalancing our demand of natures goods andservices with its capacity to supply them, Dasgupta says. It also meansaccounting fully for the impact of our interactions with nature across alllevels of society. COVID-19 has shown us what can happen when we dont do this.Nature is our home. Good economics demands we manage it better.

The critical role of biodiversity in the longevity of life as we know it hasbeen on the business worlds radar for the past few years and has spawned aflurry of ambitious and promising efforts to help us course correct at scale. In2017, the Natural Capital Impact Group developed a healthy ecosystemmetric based on the impact of a company on the quality and quantity of biodiversity,soil and water designed to aid in business decision-making. In 2019, a group ofconservation scientists, NGOs and indigenous leaders urged governments to adopta Global Deal forNature,to tackle the interlinked crises of biodiversity loss and climate change;Adobe and Pantone joined forces on a Glowing, Glowing,Gonecampaign highlighting the global danger signaled by fluorescing coral reefs; anda diverse group of influential international organizations launched a coalitioncalledBusiness forNature,aimedat ensuring that a clear understanding of the relationship between nature,people and economies became integrated into all economic sectors, and at alllevels of decision-making a need echoed in the Dasgupta report.

A countrys GDPhas long been debunked as a measure of human welfare as it ismerely a measure of the size of its economy, not an indicator of itswellbeing.Several alternatives to GDP have been put forward over the years asbetter alternatives for assessing welfare. They include theIndex ofSustainable Economic Welfare,theGenuine Progress Indicator,GrossNational Happiness, theHumanDevelopment Index,and theComprehensive Net National Product,amongothers. These methodologies either (a) also quantify the size of economies intheir own ways, or (b) do not quantify the size of economies at all and insteadrate or rank them in their own fashion.

In 2017, Center for SustainableOrganizations founder MarkMcElroy proposed a new way of measuring and reporting the performance of wholeeconomies calledAggregate CapitalSufficiency(ACS) an extension ofmulticapitalism, a new form of capitalism thatinterprets economic performance in terms of impacts on all vital capitals(natural, human, social, etc) and not just one of them (economic).ACS enablesus to measure and report thesustainabilityof an economy, not just its sizeor its inhabitants well-being.

In 2020, WWF projected a US$10T hit to the global economy by2050if global biodiversity loss remained unchecked. In the past year, globalcompanies includingKering,Natura,Procter &Gamble,TimberlandandWalmarthave embedded commitments to preserve or restore biodiversity into theirsustainability strategies but governments need to embrace this way of thinkingfor the necessary changes to take hold.

Published Feb 2, 2021 7am EST / 4am PST / 12pm GMT / 1pm CET

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Paints And Coatings Global Market Report 2021: COVID 19 Impact and Recovery to 2030 – GlobeNewswire

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New York, Feb. 03, 2021 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Paints And Coatings Global Market Report 2021: COVID 19 Impact and Recovery to 2030" - https://www.reportlinker.com/p06018803/?utm_source=GNW 87 billion in 2020 to $216.9 billion in 2021 at a compound annual growth rate (CAGR) of 8.5%. The growth is mainly due to the companies rearranging their operations and recovering from the COVID-19 impact, which had earlier led to restrictive containment measures involving social distancing, remote working, and the closure of commercial activities that resulted in operational challenges. The market is expected to reach $258.45 billion in 2025 at a CAGR of 4%.

The paints and coatings market consists of the sales of paints and coating by entities (organizations, sole traders or partnerships) that mix pigments, solvents, and binders into paints and other coatings, such as stains, varnishes, lacquers, enamels, shellacs, and water-repellent coatings for concrete and masonry, and/or produce allied paint products, such as putties, paint and varnish removers, paint brush cleaners, and frit. The paints and coatings market is segmented into water borne coatings; solvent based coatings; powder coatings and other paints and coatings.

Asia Pacific was the largest region in the global paints and coatings market, accounting for 55% of the market in 2020. North America was the second largest region accounting for 18% of the global paints and coatings market. Eastern Europe was the smallest region in the global paints and coatings market.

Biocides are being used in paints to enhance their longevity and to maintain their quality. Biocide additives have been designed to protect paints from getting damaged during storage or to keep fungi and algae from growing on the applied paints. The market for biocides in paints will continue to grow due to the switch from solvent based to water based paints as they are not hazardous for human health and environment, and minimize fungal and algae growth. However, replacement of traditional biocides based on chlorine and formaldehyde with environmental friendly biocides add to the costs of paint production. For instance, some of the major companies using biocide in paint manufacturing include The Dow Chemical Company, Troy Corporation, BASF SE, Thor Group and AkzoNobel N.V.

The outbreak of Coronavirus disease (COVID-19) has acted as a significant restraint on the paints and coatings market in 2020 as supply chains were disrupted due to trade restrictions and consumption declined due to lockdowns imposed by governments globally. COVID 19 is an infectious disease with flu-like symptoms including fever, cough, and difficulty in breathing. The virus was first identified in 2019 in Wuhan, Hubei province of the Peoples Republic of China and spread globally including Western Europe, North America and Asia. Steps by national governments to contain the transmission have resulted in a decline in economic activity with countries entering a state of lock down and the outbreak is expected to continue to have a negative impact on businesses throughout 2020 and into 2021. However, it is expected that the paints and coatings market will recover from the shock across the forecast period as it is a black swan event and not related to ongoing or fundamental weaknesses in the market or the global economy.

There is a rapid growth in consumption of paints and coatings in many industries. Paints and coatings are widely used in the automotive, construction and manufacturing industries. For instance, global buildings construction market is expected to increase from $6.6 trillion in 2019 to $8.4 trillion in 2022. Similarly, global transportation manufacturing market is expected to increase from $6 trillion in 2019 to $7.8 trillion in 2022 . Decorative paints and coatings are widely used in buildings and construction whereas protective paints and coatings are linked closely to the automotive, major appliance and industrial equipment industries. Therefore, growth in end-user industries is expected to drive the paints and coatings market during the forecast period.

Read the full report: https://www.reportlinker.com/p06018803/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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Texas A&M Seeks Dogs With Cardiac Condition For Study On Heart Drug – Texas A&M University Today

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Dr. Sonya Gordon and Dr. Elizabeth Malcolm.

Texas A&M University College of Veterinary Medicine & Biomedical Sciences

Dilated cardiomyopathy (DCM) is the second most-common acquired cardiac disease in dogs.

In its early stage, called the preclinical stage, dogs are apparently healthy to their owners, but beneath the surface, DCM causes a progressive enlarging and weakening of dogs hearts. Over time, dogs with DCM will progress to the diseases clinical phase and develop congestive heart failure (fluid in the lungs).

But what if owners of dogs with DCM had the ability to extend the amount of quality time they spend with their beloved four-legged friends?

Through The REPAIR Study (Rapamycin Treatment inPreclinical Canine Dilated Cardiomyopathy), cardiologists at the Texas A&M College of Veterinary Medicine & Biomedical Sciences (CVMBS) Small Animal Teaching Hospital (SATH) are investigating the use of the drug rapamycin in dogs with preclinical DCM.

Rapamycin, which will be distributed by the Ireland-based company TriviumVet, is a drug that affects both the immune system and metabolism; it has been shown to improve heart function and reverse age-related changes in rodents with heart disease.

The primary objective of our study is to determine if rapamycin is safe for use in dogs with preclinical DCM, as well as to evaluate the effects of this medication on heart size and function in these dogs, said Dr. Elizabeth Malcolm, an SATH cardiology resident whose work on The REPAIR Study is part of her residency research.

To complete this study, the SATH is looking to enroll 12 dogs with preclinical DCMno more than six Doberman Pinschers (the breed most commonly affected by DCM) and up to two dogs of any other breed.

Eligible dogs must be older than 3 years, be on a stable dose of pimobendan (Vetmedin) for at least 60 days prior to the screening examination, have no evidence of congestive heart failure, and not be receiving diuretic (furosemide) medication.

We know that despite proof that pimobendan (Vetmedin) can delay the onset of heart failure and death, disease progression is relentless and dogs with DCM are still destined to die from this disease, said Dr. Sonya Gordon, cardiology professor, Eugene Chen Chair in cardiology and principal investigator for The REPAIR Study. Pimobendan treatment works by reducing heart size and improving function, essentially resetting the clock; however, that clock continues to tick. We are optimistic that the addition of rapamycin will yield additional benefits that translate into increased health span and lifespan in dogs with preclinical DCM.

For this study, we require participants to continue to receive pimobendan because it is proven to be beneficial and represents the current standard of care; we are just adding rapamycin, Gordon said. Living longer is great, but the real goal is to live betterthats what health span is all about; it is the part of life when you feel great, even if you have disease.

As a cardiology resident, I see firsthand how devastating DCM is for patients and their owners. While pimobendan is an important medication that has been shown to have significant beneficial effects in dogs with DCM, we must continue to investigate additional therapies with the potential of increasing longevity, as well as enhancing the quality of life in dogs with this heartbreaking disease, Malcolm said.

Those selected to participate in the trial will take a pill three times a week and will be required to visit the SATH for enrollment screening, as well as three additional times over six months.

While this trial will hopefully lead to larger studies, its important for owners to know that if the drug works, their dogs would be eligible to continue to receive chronic treatment with rapamycin, Gordon said.

There will be no cost to owners of dogs participating in this trial; TriviumVet, the sponsor, will cover the costs for diagnostic testing, rapamycin, and Vetmedin for the duration of the study.

This is a really stand-up company. They are all about the dogs and they have a potential game changer here, because if it works its going to have a far-reaching impact, Gordon said. If we move forward with a larger study after this investigational study, Texas A&M will serve as the lead investigational site.

Rapamycin has been approved by the Food and Drug Administration (FDA) for human use and has been used safely for decades. While cardiac disease such as DCM is not among the labeled indications for which the drug is currently prescribed in humans, Gordon and Malcolm believe this trial could have important implications in human medicine given the similarities of heart disease among dogs and humans.

We are delighted to be able to bring our proprietary, novel veterinary rapamycin formulation to clinical trials in dogs and cats for a multitude of diseases, said TriviumVet CEO Louise Grubb. Our partnership with Texas A&M for The REPAIR Study has been an incredible synergy given their cardiology expertise and passion for research. The potential of this drug is far-reaching and we look forward to continuing our research with Texas A&M across cardiology and other target disease areas.

Owners with dogs diagnosed with preclinical DCMincluding those diagnosed within the past two yearsthat are interested in enrolling their dogs in this study should email tamucardiology@cvm.tamu.edu with REPAIR Study in the subject line.

For more information, including the list of exclusion criteria, visit the CVMBS Clinical Trials webpage.

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