Bite-Sized Biochemistry #28 – Citric Acid Cycle II (Oxidative Metabolism) – Video

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03-08-2011 12:33 (01/05/11) Lecture by Kevin Ahern of Oregon State University discussing Biochemistry Basics in BB 451. See the full course at oregonstate.edu This course can be taken for credit (wherever you live) via OSU's ecampus. For details, see ecampus.oregonstate.edu Download Metabolic Melodies at http://www.davincipress.com Related courses include BB 350 - oregonstate.edu BB 450 - oregonstate.edu BB 100 - oregonstate.edu Lecture Summary Citric Acid II 1. The first decarboxylation of the citric acid cycle is catalyzed by isocitrate dehydrogenase and the reaction is strongly favored to the right. The products of this reaction are NADH and alpha ketoglutarate. 2. Alpha ketoglutarate is an important intermediate for its involvement in anaplerotic reactions related to transamination (we'll talk about these later). The products of this reaction are succinyl-CoA and NADH 3. The only substrate level phosphorylation in the citric acid cycle is catalyzed by succinyl-CoA synthetase. The products of this reaction in the citric acid cycle are GTP and succinate. 4. Succinate dehydrogenase contains a covalently-linked FAD electron carrier. The Delta G zero prime of zero allows the reaction to be readily reversed to produce succinate, when needed. The products of this reaction in the forward direction of the citric acid cycle are FADH2 and fumarate (trans double bond). 5. Addition of water to fumarate (catalyzed by fumarase) yields L-malate. 6. Oxidation of L-malate by malate dehydrogenase yields NADH ...

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Bite-Sized Biochemistry #28 - Citric Acid Cycle II (Oxidative Metabolism) - Video

Strategic Analysis of the European Stem Cell Research Tools Market

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NEW YORK, Feb. 6, 2012 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Strategic Analysis of the European Stem Cell Research Tools Market

http://www.reportlinker.com/p0769016/Strategic-Analysis-of-the-European-Stem-Cell-Research-Tools-Market.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biological_Therapy

The primary objective of this study is to measure brand perceptions of tools and technologies currently at the forefront of stem cell research: bio-imaging and microscopy, cell biology tools, immunochemicals, molecular biology tools, and protein biochemistry tools. The study also looks into the usage pattern of these tools. An extensive end-user survey was conducted with 25 laboratories to assess the requirement and usage of tools. Insightful review of key industry drivers, restraints and challenges have been discussed. Leading market players and the prevailing competitive landscape for each of the segments have been discussed.

Table of ContentsExecutive Summary 10-19

Executive Summary 11-13

Market Engineering Measurements 14

Scope & Objective 15

Technologies Employed for Stem Cell Research 16

Stem Cell Research Protocol 17

CEO's Perspective 18

Exchange Rates 19

Market Overview 19

Market Overview - Definitions 20-24

Market Overview 25-26

Market Overview - Segmentation 27

European Stem Cell Research End User Trends 28

Stem Cell Research Workflow 29

Purpose of Research and Profile of Respondents 30

Stem Cells and Tools Usage Trends 31-33

Tools and Equipment Budget for Stem cell research Tools 34

Market Outlook 35

Market Age 36

Funding for Stem Cell Program 37-39

External Challenges: Drivers and Restraints 40

Industry Challenges 41-45

Drivers & Restraints 46

Key Market Participants 52

Product Line Analysis 59

Forecasts and Trends -Total Stem Cell Research Tools Market 70

Forecast Assumptions 72

Revenue Forecasts 73-74

Bio Imaging Tools In Vivo and In Vitro Segment Breakdown 75

Revenue Forecasts 77-78

Market Share Analysis 79

Cell Biology, Protein Biochemistry, and Immunochemical Tools Segment Breakdown 80

Revenue Forecasts 82-83

Market Share Analysis 84

Molecular Biology Tools Segment Breakdown 85

Revenue Forecasts 87-88

Market Share Analysis 89

Demand Analysis 90

Bioimaging Tools In Vivo and In Vitro 92

Cell Biology Tools 93

Demand Analysis Molecular Biology Tools 94

Protein Biochemistry Tools 95

Immunochemical Tools 96

European Stem Cell Research Centers 97-99

SWOT Analysis 101-102

Strategic Recommendations and Conclusions 103-106

The Last Word 107

Appendix 110

List of Figures

Total Stem Cell Research Tools Market: Market Overview, Europe, 2010 25Total Stem Cell Research Tools Market: Tools Usage Trends, Europe, 2010 32-33Total Stem Cell Research Tools Market: Market Outlook, Europe, 2010 35Total Stem Cell Research Tools Market: R&D Programs Funded, Europe, 2006–2013 37Total Stem Cell Research Tools Market: Bioimaging Tools In Vivo and In Vitro End User Analysis, Europe, 2010 92Total Stem Cell Research Tools Market: Cell Biology Tools End User Analysis, Europe, 2010 93Total Stem Cell Research Tools Market: Molecular Biology Tools End User Analysis, Europe, 2010 94Total Stem Cell Research Tools Market: Protein Biochemistry Tools End User Analysis, Europe, 2010 95Total Stem Cell Research Tools Market: Immunochemical Tools End User Analysis, Europe, 2010 96

List of Charts

Percent Revenue Breakdown Total Stem Cell Research Tools Market: Europe, 2010 27

Percent Revenue Breakdown Total Stem Cell Research Tools Market: Europe, 2017 27

Total Stem Cell Research Tools Market: Purpose of Research and Profile of Respondents, Europe, 2010 30

Total Stem Cell Research Tools Market: General and Primary Focus on Stem Cell Research, Europe, 2010 31

Total Stem Cell Research Tools Market: Lab Budgets, Europe, 2010 34

Total Stem Cell Research Tools Market: Lab Budget Estimations, Europe, 2011 34

Total Stem Cell Research Tools Market: Segment Life Cycle Analysis, Europe, 2010 36

Total Stem Cell Research Tools Market: Industry Challenges, Europe, 2011–2017 41

Total Stem Cell Research Tools Market: Drivers and Restraints, Europe, 2010 46

Total Stem Cell Research Tools Market: Product Line Analysis, Europe, 2010 59-67

Market Overview Total Stem Cell Research Tools: Europe, 2010 71

Total Stem Cell Research Tools: Revenue Forecast, Europe, 2010–2017 73

Market Overview Bioimaging In Vivo and In Vitro Market: Europe, 2010 76

Bioimaging Tools In Vivo and In Vitro Market: Revenue Forecasts, Europe, 2010–2017 77

Bioimaging In Vivo and In Vitro Market: Market Share Analysis, Europe, 2010 79

Market Overview Cell Biology, Protein Biochemistry, and Immunochemical Tools Market: Europe, 2010 81

Cell biology, Protein Biochemistry, and Immunochemical Tools Market Revenue Forecasts, Europe, 2010–2017 82

Cell Biology, Protein Biochemistry, and Molecular Biology Tools Market: Market Share Analysis, Europe, 2010 84

Market Overview Molecular Biology Tools Market: Europe, 2010 86

Molecular Biology Tools Market: Revenue Forecasts, Europe, 2010–2017 87

Molecular Biology Tools Market: Market Share Analysis, Europe, 2010 89

Total Stem Cell Research Tools Market: Research Centers and Universities, Europe, 2010 98-100

Total Stem Cell Research Tools Market: SWOT Analysis, Europe, 2010 102

To order this report:Biological Therapy Industry: Strategic Analysis of the European Stem Cell Research Tools Market

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Wash. considers collecting DNA upon arrest

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Anthony Dias is the poster boy for why police and prosecutors hope Washington will join a growing number of states that require people to give DNA samples as soon as they're arrested for a serious crime, rather than waiting until they're convicted.

In 2005, Dias was released on bail while facing a felony hit-and-run charge in Pierce County. He went on to commit crimes against 19 more people before the year was up, including a half-dozen rapes. If he had given a DNA sample after his hit-and-run arrest, detectives could have caught him after the first rape — not the last.

"By the time he committed his next rape crime, he could have been identified, arrested and taken off the streets," Charisa Nicholas, who was tied up and forced to watch as her roommate was raped, told lawmakers recently. "My case would have been the first case prevented."

Nevertheless, the rush to expand DNA's use in criminal investigations worries privacy advocates, and courts around the country have disagreed about whether such laws violate the 4th Amendment to the U.S. Constitution, which protects people from unreasonable searches and seizures. Many judges have found that routinely collecting DNA from convicts is OK because, among other reasons, committing a serious crime reduces their expectation of privacy. It's not clear that reasoning would extend to people who have not been convicted and who are presumed innocent.

"The way judges come out depends in a sense on how much trust they have in the government," says Penn State Law School professor DH Kaye, who tracks the issue. "Some judges say, 'What's the big deal? It's like a fingerprint.' But DNA samples contain a lot of information, and other judges say that sooner or later somebody is going to abuse the system."

Under bills before Washington's Legislature, the state would collect DNA from people when they're arrested for nearly all felonies or for violating a domestic violence protection order. Once a judicial officer finds that the arrest was supported by probable cause, the State Patrol crime lab could test the DNA to create a profile and enter that profile in a nationwide database used to help solve crimes. The cost of the measure — more than $400,000 a year — would be paid with money from traffic tickets.

If the person is exonerated or not charged, they could petition to have the crime lab destroy their sample and profile. The lab would be obligated to do so, but could run a check on the profile first.

About half the states and the federal government have similar laws.

The 3rd U.S. Circuit Court of Appeals in Philadelphia, the highest federal court to rule on the issue so far, closely upheld the federal law 8-6 last summer in a case that could be headed for the Supreme Court. The majority found that although crime labs typically maintain the actual DNA samples, the profiles entered into the national database comprise only a small portion of the information available in the sample. There's no indication that the government has any intent to use the full samples, judges said.

The judges reasoned that the government has a right to confirm the identities of the people it arrests, and there are two parts to someone's identity: who they are, and what they've done. Using the DNA profile to see if arrestees have committed other crimes is a part of the government's interest in their identities, the judges said.

The dissent argued that the government doesn't need the DNA profile to identify arrestees. Officials want to be able to conduct an intrusive search of a person's body — taking their DNA — without a warrant and without suspicion, in hopes of finding evidence unrelated to what the person has been arrested for.

"We do not view a finding of probable cause for one crime as sufficient justification to engage in warrantless searches of arrestees' or pretrial detainees' homes for evidence of other crimes," the dissent noted.

That's one of the analyses offered by Doug Klunder, privacy counsel at the American Civil Liberties Union of Washington.

"It's collecting really sensitive information about an individual without there being reason to suspect that person of a crime," he says. "There are many ways that law enforcement could collect information that would help solve crimes. They could rifle through my house every day and maybe they'll find it, but we don't allow that without a warrant. Certainly going into my body is as intrusive as going into my house."

Virginia's Supreme Court has upheld that state's law, and an appeals court in Arizona has OK'd the law there. However, California and Minnesota appeals courts have rejected their laws, and a panel of the 9th U.S. Circuit Court of Appeals has yet to rule on a federal challenge to California's law, even though the arguments took place 18 months ago.

Washington's proposal could face an even tougher legal road if passed, because the state Constitution is even more protective of people's right to be free from intrusion by the government.

"There's not a definite answer on the constitutional questions," says Pierce County Prosecutor Mark Lindquist. "But the merits of this are so obvious it's worth having it go up to the courts."

___(equals)

Johnson can be reached at https://twitter.com/GeneAPseattle

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Wash. considers collecting DNA upon arrest

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Short Delay in Treating Blood Pressure Safe for Diabetics: Study

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(HealthDay News) -- Waiting up to a year to treat high blood pressure in a person with diabetes is probably not harmful, but waiting many years to get blood pressure under control could result in serious complications, new research indicates.

In the study, published online Jan. 9 in the Journal of General Internal Medicine, researchers from the University of Chicago suggested that the one-year delay could give patients time to make certain lifestyle changes that could help correct the problem, such as limiting their salt intake, exercising or losing weight.

The study also suggests that delays in lowering blood pressure among patients with diabetes are not uncommon. Some patients may not have access to health care, while others may not follow through on their treatment, they explained. Read more...

Immunice for Immune Support

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Healthiest Chocolate Comes in Small Packages

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Chocolate Pieces

A little goes a long way (Sharon Basaraba ©)

Attention all chocolate lovers (and that's a club with a lot of members): when it comes to choosing which chocolate is the healthiest, quantity, and frequency, may be more important than quality.  A couple of fairly recent research reviews looking at the effect of chocolate consumption and cardiovascular disease, analysed how often, and how much, chocolate people ate, without distinguishing between milk or dark chocolate.  For example, in a British Medical Journal review of seven studies involving about 114,000 subjects, University of Cambridge researchers concluded those who ate chocolate more than twice a week had a 37 per cent lower chance of developing heart disease, and a 29 per cent lower risk of stroke - whether they ate their chocolate dark, in drinks, baking or as nutritional supplements.

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Bobcat Senior Honoary Applications Available online Monday, February 6th, 2012:

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Attention All Qualified Juniors,
Bobcat Senior Honorary Applications will be available online Monday, February 6th, 2012. We wanted to inform you in advance, that we will be holding an informational meeting at 7:00pm on Tuesday, February 7th, 2012 in the Swede Johnson Building, located on the corner of Speedway Blvd and Cherry Avenue. The address of Swede Johnson is 1111 N Cherry Avenue and parking is free.
Established in February 1922, Bobcats have enjoyed a long and rich history being recognized as one of the first organizations on campus. Founded for the purpose of preserving the unity and welfare of the University of Arizona, each one of its 13 members has a strong connection and pride for their school. Bobcats annually help organize and plan Homecoming, Evening of Excellence as well as other community service projects that aim to promote the U of A.
Members of Bobcats Senior Honorary are selected on the basis of their scholastic achievement, leadership, university and community involvement, and a sincere commitment to the University of Arizona.
We encourage you to attend the informational meeting on February 7th and come prepared to ask any questions about the organization and application process. In the meantime, please be sure to like our Facebook page Bobcats Senior Honorary 2012-2013 Selections.
We sincerely encourage you to consider applying to the Bobcats Senior Honorary. If you have any questions please feel free to contact us.
Bear Down,
Matt Morris & Jessica Regan
Selection Chairs
Bobcats Senior Honorary
bobcatsselections@gmail.com

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Emergency Medicine Club at the U of A

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The Emergency Medicine Club at University of Arizona College of Medicine is proud to present:
CLINICAL SKILLS NIGHT: PHYSICAL EXAM TECHNIQUES
When: Thursday, February 9, 2012 from 5:30-7:30pm
Where: U of A College of Medicine Student Clinic (on the 3rd floor of the College of Medicine, directions will be provided)
Who: Open to 20 enthusiastic undergraduate students
What: Medical students from the EM Club will teach you basic parts of a physical exam such as:
•Vitals
•HEENT (Head, Ears, Eyes, Nose, Throat)
•Cardiovascular
•Respiratory
The second half of the event there will be pizza and a Q&A session with the medical students.
This event is free to undergraduate EM club members, $10 for non-members, or $20 for a lifetime EM Club membership and a UA Emergency Medicine pen light (membership forms will be available at the event).
If interested, please RSVP to uaemclub@gmail.com with your name, email address, phone number and if you are an EM club member.
You will be sent a confirmation e-mail within 48 hours of signing up and I will notify the physiology listserv when available spots are full for this event.
Please let me know if you have any questions,
Ashley Bartholomew
UofA College of Medicine
Class of 2014
EM Club Officer

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BREAKING: Healthcare Hero SAVES HIMSS12!

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Confused by EHRs, Meaningful Use, medication management, federal regulations, and other health IT topics?

Want more, positive clinical outcomes, greater information exchange, increased office efficiency, and cost savings?

Visit booth 5456 at HIMSS12 to meet the DRFIRST Defender and learn how he helps protect providers! 

Comment on the video, Tweet us @DrFirst #HIMSShero, or comment on http://www.facebook.com/drfirstinc to be entered into a drawing for a night on the town in Vegas at HIMSS12!

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Recently published articles in Journal of Pathology Informatics

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 Number of great articles recently published in the increasingly popular Journal of Pathology Informatics.

Number of recent works dealing with digital pathology related projects:

Multi-field-of-view strategy for image-based outcome prediction of multi-parametric estrogen receptor-positive breast cancer histopathology: Comparison to Oncotype DX
Ajay Basavanhally, Michael Feldman, Natalie Shih, Carolyn Mies, John Tomaszewski, Shridar Ganesan, Anant Madabhushi
J Pathol Inform 2011, 2:1 (19 January 2012)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]
 
Local isotropic phase symmetry measure for detection of beta cells and lymphocytes
Manohar Kuse, Yi-Fang Wang, Vinay Kalasannavar, Michael Khan, Nasir Rajpoot
J Pathol Inform 2011, 2:2 (19 January 2012)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]
Jpicover
Prostate cancer detection: Fusion of cytological and textural features
Kien Nguyen, Anil K Jain, Bikash Sabata
J Pathol Inform 2011, 2:3 (19 January 2012)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

 

Automatic annotation of histopathological images using a latent topic model based on non-negative matrix factorization
Angel Cruz-Roa, Gloria Díaz, Eduardo Romero, Fabio A González
J Pathol Inform 2011, 2:4 (19 January 2012)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

 

A fully automated approach to prostate biopsy segmentation based on level-set and mean filtering
Juan Vidal, Gloria Bueno, John Galeotti, Marcial García-Rojo, Fernanda Relea, Oscar Déniz
J Pathol Inform 2011, 2:5 (19 January 2012)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]
Feasibility analysis of high resolution tissue image registration using 3-D synthetic data
Yachna Sharma, Richard A Moffitt, Todd H Stokes, Qaiser Chaudry, May D Wang
J Pathol Inform 2011, 2:6 (19 January 2012)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]
Atlas-guided correction of brain histology distortion
Xi Qiu, Lin Shi, Tony Pridmore, Alain Pitiot, Defeng Wang
J Pathol Inform 2011, 2:7 (19 January 2012)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]
Global error minimization in image mosaicing using graph connectivity and its applications in microscopy
Parmeshwar Khurd, Leo Grady, Rafiou Oketokoun, Hari Sundar, Tejas Gajera, Summer Gibbs-Strauss, John V Frangioni, Ali Kamen
J Pathol Inform 2011, 2:8 (19 January 2012)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]
Interactive registration of 2D histology and 3D CT data for assessment of radiofrequency ablation treatment
Matthias Seise, Tuomas Alhonnoro, Marina Kolesnik
J Pathol Inform 2011, 2:9 (19 January 2012)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]
Biomechanical model-based deformable registration of MRI and histopathology for clinical prostatectomy
Navid Samavati, Deirdre M McGrath, Jenny Lee, Theodorus van der Kwast, Michael Jewett, Cynthia Ménard, Kristy K Brock
J Pathol Inform 2011, 2:10 (19 January 2012)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]
A comparison of sampling strategies for histological image analysis
André Homeyer, Andrea Schenk, Uta Dahmen, Olaf Dirsch, Hai Huang, Horst K Hahn
J Pathol Inform 2011, 2:11 (19 January 2012)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]
Learning histopathological patterns
Andreas Kårsnäs, Anders L Dahl, Rasmus Larsen
J Pathol Inform 2011, 2:12 (19 January 2012)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]
Graphical processing unit implementation of an integrated shape-based active contour: Application to digital pathology
Sahirzeeshan Ali, Anant Madabhushi
J Pathol Inform 2011, 2:13 (19 January 2012)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

 

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Sales Account Manager Position Open at Aperio

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This position is focused and very skilled in the area of Digital Pathology

The Digital Pathology Sales Account Manager will possess specialized and in-depth comprehensive knowledge and experience in Digital Pathology as the Subject Matter Expert in image analysis for the US Healthcare Sales Team.  Candidate will develop and execute successful Digital Immunohistochemistry (DIHC) solution sales strategies, update sales tools and tactics to drive growth and revenue to the hospital market throughout the US.  You will partner, train and support all US Healthcare Sales Representatives in Digital IHC sales and marketing skills allowing pathologist to significantly streamline clinical workflow and improve patient care through digital pathology. 

Candidate must have an impressive history of consistent sales success to clinical reference labs and to hospitals in complex sales with a solid understanding of the histology environment. This position will call on both existing customers and new business with a focus and quota for selling Aperio’s Digital IHC solutions.  Candidate must be comfortable calling on the C-Suite, delivering vision, and orchestrating multi departmental/site evaluations.   You must have excellent skills focusing on differentiation, forecasting, negotiating and closing while working in concert with US Healthcare Sales team. 

As the SME in Digital IHC solutions, you will also partner with the Healthcare Representatives throughout the US to educate and support them in driving the Digital IHC business to closure with their customers.  To be successful, candidate must be highly motivated, display independent initiative and thrive on the independence, flexibility and variety offered by this specialized sales position for Aperio. 

The Digital Pathology Sales Account Manager is someone who can:

  • Target clinical reference labs and hospital accounts that would benefit from Aperio’s Digital IHC Systems
  • Collaborate with the US Healthcare sales team as the Subject Matter Expert in image analysis to assist in achieving complex goals 
  • Independently perform needed activities in all areas of responsibility to achieve Aperio’s business goals
  • Develop and execute successful Digital IHC solution sales strategies for the US Healthcare market
  • Partner, support, educate and train Healthcare Reps throughout the US in DIHC sales
  • Provide direction on issues of DIHC and assist Healthcare Reps and Sales Managers in setting strategy direction
  • Develop, communicate and deliver the vision and benefits of Digital IHC Systems to the hospital market
  • Demonstrate proven experience in pathology product sales, imaging sales and a solid understanding of the reimbursement aspects of clinical lab business
  • Coordinate effective sales activities within national, multi-site, hospitals and/or IDN’s
  • Proactively review best practices and process improvements to ensure competitiveness within a rapidly changing environment and to provide proper strategies to and meet deliverables

Desired Skills & Experience

Qualifications:

  • Proven record of successful sales of Digital Pathology solutions
  • Expert in image analysis
  • Solid understanding of the histology environment
  • Ability to create DIHC sales strategies, plans and activities to exceed sales goals
  • Demonstrates outstanding professional communication and interpersonal skills; communicates with C-suite level, pathologists, doctors, laboratory managers, internal partners
  • Ability to educate, support and train US Healthcare Reps in the area of Digital IHC
  • Ability to manage multiple tasks with shifting priorities and timeframes
  • High level of initiative, creative thinking, decision making and problem resolution skills
  • Works independently but able to interact as a partner and team member
  • Inherent ability to influence of others 

Requirements:                            

  • BA/BS
  • Minimum 5-7 years successful selling experience into hospitals (medical capital or software solutions)
  • Extensive understanding of pathology market
  • Extensive understanding of histology laboratory environment and Digital IHC (immunohistochemistry)
  • Excellent written and verbal communications skills
  • Ability to work with others to train and educate them to be successful in DIHC
  • Track record of rapidly and consistently generating sales revenue
  • Ability to travel a significant percentage of time

Location and type:

Full-time employment in Western US near a major airport

Compensation and benefits:

Aperio pays our great people salaries commensurate with market value, and provides full benefits including health benefits and a 401(k) plan.  All Aperio employees participate in our stock option plan. 

To Apply:

Submit your resume in word format to jobs@aperio.com. Please include the position title in the subject line.

Aperio is committed to attracting and retaining the most highly qualified candidates available. As an Aperio employee you will be consistently challenged to deliver your best. Because we provide our customers the best technologies and service in the industry, you will constantly develop new skills, learn new products, and be involved in activities that are highly valued in the marketplace. At Aperio, we value our customers as partners, and therefore strive to deliver excellence in everything we do.

Aperio is an equal opportunity and affirmative action M/F/V/D employer.  We support workforce diversity. EEO/AA M/F/V/D

 

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iPad proves equal to regular screens for TB evals

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Admittedly, mobile small screen technologies afford portability and perhaps in some cases, access to basic health care services that would not normally be availalable.  True in pathology, just as it is radiology. Look for more news to come on this related to digital pathology.  Based on some recent papers I have reviewed for publication, small screen technologies will show their effectiveness for primary H&E diagnosis and extend the pathologist's reach.  

From: FierceMobileHealthcare

 By Sara Jackson Comment |  Forward | Twitter | Facebook | LinkedIn


iPads are just as good as LCD monitors when it comes to diagnosing tuberculosis, according to a follow-up study recently conducted by the University of Maryland.

The original study, which took place in mid-2010, tested only 30 images  found that the original iPad's resolution wasn't quite as good as that of LCD monitors and wasn't sufficient for a primary diagnosis.

In the new study, five radiologists tested 240 images--200 positive and 40 negative--on iPad 2 tablets and on a 27-inch Mac monitor. The agreement between the two displays was statistically equal, researchers report.

"Mobile displays should provide an effective extension of the radiologist's reach," researcher Samir Abboud told radiology news site AuntMinnie.com.

The two big negatives for the mobile technology were speed and size. All of the radiologists reported the iPad2 was far slower than the LCD monitor and that the screen size just couldn't compete with the larger monitor.

"It took, on average, twice as long to view the dataset on the iPad than on the traditional workstation," Abbout said. "Readers also commented on how much smaller the iPad's screen was compared to the 27-inch monitor."

The university's findings are an interesting turnaround for the industry, considering that experts reported to AuntMinnie last fall that tablets were "impractical" for viewing medical images, and likely would never take the place from LCD workstations.

"You won't find a radiologist who wants to read a chest X-ray off an Apple iPad," Dr. David Hirschorn, director of radiology informatics at Staten Island University Hospital said at the time.

To learn more
- read the AuntMinnie article (registration required)

Related Articles:
Mobile devices 'impractical' for medical image viewing
Carestream wins FDA approval for medical image viewing on tablets
RSNA: iPad helps untether radiologists from reading room

Read more about: table computers, Mobile Healthcare, iPad, healthcare apps
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HealthTap’s Social Network of 5,000 Doctors Is Ready to Give Free Advice

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Back in the 1990's when our department had a website, I started uploading several powerpoint lectures from various sources with the intent that such material would be used as what was then a growing source of information online that was peer-reviewed, accurate and current.

It quickly became apparent the need and desire by patients to reach out and inquire about their own individual cases based on the lecture material.

One in particular stands out, a lecture dealing with cervical cytology, abnormal pap smears, therapy and follow-up.  At first there were only a handful of e-mails which quickly became dozens and hundreds of such inquiries. 

Initially, I referred the questions (and essentially the patients) to gynecology and gynecology oncology colleagues who at first were willing to respond to patients and in some cases, provide professional services if the patients desired.  Ultimately, based on the volume of inquiries and growing concern about patient privacy, e-mail communication and risks to providers, I removed the lectures.

The story was similar for lectures related to brain tumors, prostate pathology and microbiology.

Since then we have watched the trials and tribulations with sites and services such as Dr. Koop, Google Health and WebMD.

Now comes news of a social media network that works for patients and providers from HealthTap:

It’s fair to raise an eyebrow when a social network for healthcare comes along, but this network just might make you raise both eyebrows in surprise: HealthTap has created a healthcare social network with more than 5,000 real-live doctors to answer patient questions. Not peers, not “experts” and not brands. Health questions aren’t posted for the world to see or comment on. This is a private network between a patient and thousands of doctors.

“Facebook and Twitter are dangerous for doctors, but everyone wants to take part in social networking,” says HealthTap CEO and founder Ron Gutman, referring to the perils of patient confidentiality and lawsuits for giving wrong advice. Social and medicine haven’t boded well under the shared banner of technology, but Gutman is creating a social environment that works for doctors and patients.

HealthTap is launching a mobile app (free) called HealthTap Express that lets users ask any health question and get immediate answers from more than 5,000 doctors for free. This isn’t Yahoo Answers or Quora. Questions asked on HealthTap are always answered by a professional held accountable for their answers, which can be reviewed by peers. These are real, North American-based doctors with licenses and contact information.

Getting these doctors to become part of a social network was no small task. HealthTap began 20 weeks ago (Gutman refers to the time in “weeks,” similar to the way a new parent refers to the age of their child)  as a network for OB/GYNs and pregnant women. This was a smart vertical to tackle first; as many doctors in this field are some of the industry’s most vocal about preventative medicine, patient rights and universal healthcare. Word spread of the network, like it does for all successful social networks, and today HealthTap’s app has grown to incorporate 82 healthcare fields. The app is available for iOS and Android, smartphones and tablets.

Read more.

Source: New York Times

 

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Former Aperio Executive and Digital Pathology Market Expert, Dr. Martin Stuart, Joins Definiens Executive Team

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Munich, Germany – January 31, 2012 - Definiens, the global leader in Health Image Intelligence and Quantitative Digital Pathology, has appointed Martin Stuart, PhD, as its Executive Vice President and General Manager North America and Asian Pacific. In his new role, Stuart will be responsible for expanding the Definiens business in North America and Asia and providing leadership to the sales and field operations. 

Martin Stuart, a former Senior Vice President and General Manager of Aperio, is one of the most influential leaders in the Digital Pathology industry. He has more than 25 years of experience in international sales and marketing, specializing in the introduction of new and disruptive technologies. In his previous global sales and marketing position he was a key driver in making Aperio the leading provider of digital pathology, with more than 850 deployed slide scanner systems in more than 30 countries. Prior to Aperio, Stuart was Global Vice President of Sales and Services for Entropia Inc., a desktop grid computing company focused on the Life Sciences market.

"I’m excited to join the market leader in Quantitative Digital Pathology" comments Stuart. "Image analysis is a major driver of adoption and I’m extremely impressed by the results customers are getting by deploying Definiens products and solutions. There is enormous demand for solutions that help pathologists deal with the increasing complexities of their discipline as they support the transition to personalized medicine. I see Definiens as best positioned to address this demand by providing comprehensive decision support solutions."

"We are extremely pleased to have Martin join Definiens at a time when demand for our products is growing rapidly" says Thomas Heydler, CEO of Definiens.  "His executive experience in the digital pathology business coupled with a profound domain background makes him an ideal fit for our team. With this appointment we will significantly increase both our Life Sciences and our Healthcare Business."

About Definiens

 Definiens is a leading Health Image Intelligence™ company that develops software solutions for biomedical image analysis, data mining and clinical decision support. The company’s software analyzes images from cell-based assays, whole tissue slides and full body scans and allows users to correlate this information with data derived from other sources, supporting better decisions in research, diagnostics and therapy. By automating analysis workflows and generating new knowledge, Definiens provides pharmaceutical and biotechnology companies, research institutions, clinical service organizations and medical professionals with deeper insights, faster results and better decision support. Harnessing the power of image intelligence, Definiens supports personalized medicine and aims to significantly improve the quality of patients’ lives.

Definiens is headquartered in Munich, Germany, and has offices throughout the United States. Further information is available at http://www.definiens.com.

 

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Kaiser Permanente launches EHR mobile app

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 By Sara Jackson Comment | Forward | Twitter | Facebook | LinkedIn

 

Kaiser Permanent today launched a mobile app giving more than 9 million patients access to their online medical records. The healthcare giant created a mobile-optimized version of its member website, kp.org, with a companion Android app. The company promises an iPhone app later this year.

Kaiser officials say members will be able to view information from past visits, access lab results and pharmacy orders and see other data from their records. They also will be able to check appointments and exchange texts with clinicians via smartphone.

It's remarkably quick work, considering that just last August, Kaiser IT reps admitted they had virtually no mobile strategy crafted, and no apps under development other than the KP Locator mapping app released at the end of the summer.

But they seem to have had a little push from users. In a 2011 study of Kaiser members, smartphone users said the ability to access kp.org's My Health Manager functions from their phones was what they wanted most. And even without the optimization for mobile devices, visits to the kp.org website from smartphones skyrocketed 46 percent during 2011, to make up 14 percent of total visits to the site.

To learn more:
- read the announcement

Related Articles:
Make sure your hospital's mobile strategy is deliberate
Kaiser debuts mobile app

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Amazing Animated Gifs of a Circa 1920s Coney Island, from "Speedy," 1928

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Animated gifs created from he nighttime Coney Island sequence featured the 1928 Harold Lloyd vehicle Speedy. You can watch the clip from which it is is drawn by clicking here.

Synopisis of the film, from IMDB:

Speedy (1928)
"Speedy" loses his job as a soda-jerk, then spends the day with his girl at Coney Island. He then becomes a cab driver and delivers Babe Ruth to Yankee Stadium, where he stays to see the game. When the railroad tries to run the last horse-drawn trolley (operated by his girl's grandfather) out of business, "Speedy" organizes the neighborhood oldtimers to thwart their scheme. Written by Herman Seifer

Found here.

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Observatory’s Lunar-Themed 3rd Anniversary Fundraiser Party, Sponsored by Le Fée Absinthe, Saturday February 18th

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I would like to cordially invite each and every one of you to our upcoming lunar-themed Observatory anniversary/fundraiser party! A few things you should know: The charming Lord Whimsy will be on hand to MC! Giveaways will be provided by Kikkerland! Libations served up compliments of La Fée Absinthe! Viewings of The Midnight Archive! And music, too.

Full details follow. Hope to see you there!

Observatory’s Lunar-Themed 3rd Anniversary Fundraiser Party, Sponsored by Le Fée Absinthe!
Date: Saturday, February 18th
Time: 8pm
Admission: $20

Yes, friends, we're over the moon about our 3rd Anniversary! Come celebrate with us, and help support your favorite interdisciplinarian art, science, & occult event space.

Check out our art show, Lunation: Art on the Moon, and then trip out to a Moon Phantasmagoria show by VJ Fuzzy Bastard. We'll also be screening episodes from the Midnight Archive, a show featuring your favorite Observatory masterminds.

Libations will be provided courtesy of La Fée Absinthe.

There will also be:

The luminous MC Lord Whimsy!

Stellar giveaways courtesy of Kikkerland!

Out-of-this-world raffle prizes, including:

Gift certificates from the scrumptious SweetWolf's and the delectable Palo Santo!

Moonrise Perfume from Herbal Alchemy!

Audiobooks from Hachette!

Occult Book Set including an autographed copy of Mitch Horowitz's Occult America (Bantam), and Manly P. Hall's The Secret Teachings of All Ages (Tarcher/Penguin)!

Abraxas International Journal of Esoteric Studies with accompanying occult music CD!

Lunavision Ritual Tea Set from Rebis Remedies!

And so! much! more! We look forward to seeing you there.

More info can be found here.

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Upcoming Morbid Anatomy Presents Events: "Granny Dump Mountain" and "Buried Alive!" A Matchbox Theatre Exploring the 19th C Fear of Being Buried Alive

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Coming up tomorrow night as part of Morbid Anatomy Presents at Observatory, we have the illustrated story of Justin Nobel's journey in search of the truth behind the Japanese concept of obasute-yama or Granny Dump Mountain. Coming up next week, we have the eagerly anticipated "Buried Alive," a miniature matchbox theatre performance (pictured above) which describes itself as a "frightfully funny exploration of our fear of being buried alive and of the curious phenomenon of 19th Century 'waiting mortuaries.'"

Full details follow for both events. Hope to see you at one of both!

The Search for Granny-Dump Mountain
Illustrated lecture by Journalist Justin Nobel
Date: Thursday, January 26th
Time: 8:00
Admission: $5
Presented by Morbid Anatomy

When elders in rural Japan reached age 70--or so an ancient legend would have it--their sons would carry them to the top of a holy mountain and leave them to die of exposure and starvation. Granny-dump mountain, or obasute-yama, was seen as a way to trim the population and make way for the next generation in cold mountain villages where food was short and winter was long. It is referenced by the obscure eleventh century diarist Lady Sarashina, master haiku poet Matsuo Basho and a 1983 Palme d’Or winning film, yet most anthropologists doubt the practice ever actually existed.

Intrigued by this story, journalist Justin Nobel took to the road to see if he could get to the bottom of this enigmatic legend. His travels ultimately led him to a tiny town in northern Japan haunted by cannibalistic mountain men and shape shifting sprites. After scouring the countryside for clues he came to a shocking conclusion: the legend was very much alive, right in the heart of Tokyo.

Tonight join Morbid Anatomy and Justin Nobel to hear the story of his search for the elusive Granny-Dump Mountain.

Justin Nobel is a freelance journalist. His writing has appeared in TIME, Popular Mechanics, Audubon, Guernica and Meatpaper. His essay, The Last Inuit of Quebec, was recently included in Best American Travel Writing 2011 (Houghton Mifflin Harcourt). He pens a blog called Digital Dying for the funeral information website funeralwise.com and another called the Absurd Adventurer where he sits for hours in one New York City spot. He lives in Blissville.

Image: A plaque commemorating Granny-dump Mountain in the northern Japan town of Tono. (Photo by Justin Nobel)

PERFORMANCE: Buried Alive! A Matchbox Theatre
A matchbox theatre performance by Deborah Kaufmann
Dates: Thursday, February 2nd AND Friday February 3rd
Time: 8:00 PM
Admission: $12
Presented by Morbid Anatomy
*** Audience limited to 25 people per show; first come, first served

“The way each box reveals its tiny inhabitants is entrancing and Deborah Kaufmann… is sweetly enchanting.” – The Village Voice

“Depicted with comic deadpan perversity… a wink and raised eyebrow of an entertainment.” – http://www.womanaroundtown.com

Buried Alive! a matchbox theatre, is a frightfully funny exploration of our fear of being buried alive and of the curious phenomenon of 19th Century “waiting mortuaries.” Based on historical and medical facts. Tiny, intimate and interactive, full of dreadful discoveries for an adult audience.

BURIED ALIVE! is performed on a tabletop and is constructed entirely in and of matchboxes. It takes advantage of the unique qualities of these tiny stages. Images and characters slide out, slide through, pop up, and drop out of the matchboxes. A merry eccentric matron is your guide. The Nineteenth Century is evoked, but BURIED ALIVE! is creatively anachronistic and plays with scale.

Buried Alive! was inspired by an article entitled, “Pediatric Brain Death,” found in a hospital resident on-call room, and by research into the myths, truths, history and ethics surrounding the true moment of biological death.

Conceived, constructed and performed by Deborah Kaufmann. Kaufmann has delighted audiences in Europe, Australia and across North America with original physical comedy. This year she celebrates 25 years with the Big Apple Circus Clown Care program, where she brings the joy of circus to hospitalized children, their families and caregivers. She has been called, “by no means merely cute ... a performer to be trusted, enjoyed and seen” ---nytheatre.com

To be alerted to future events, "like" Morbid Anatomy on Facebook by clicking here or sign up for the Observatory mailer by clicking here. You can find directions to Observatory here and more on all events here. You can find out more about these events by clicking here.

Image: Photo by Jim Moore, 2011

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Automatons in the News AND at the Airport!

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Our buddy Jere Ryder of the Guinness Collection of automata at the Morris Museum just forwarded me a CBS video that features his automata collection, a truly enchanting automaton at the Franklin Institute in Philly (which, we are informed, inspired the book The Invention of Hugo Cabret), and provides a very engaging history of the craft to boot. Highly recommended! To view, simply press the play button above.

Also, for the automaton lovers among you who happen to be passing through the San Francisco International Airport international terminal before June 2012, you can go check out some automatons on display between flights! Click here for more on that. More on the Morris Museum collection can be found here.

Thanks very much to Jere Ryder for sending these links along.

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