Bethesda wants to bring humanity to Fallout 76 through NPCs – GamesIndustry.biz

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There's a new trend emerging of AAA open world games built for longevity that flop at launch, only for the studios behind them to spend months, even years trying to save them.

No Man's Sky is one shining example of a rally that worked. Anthem, despite sputtering along for a year already, is just now beginning the process. And in about a month we'll see whether the results of Bethesda's attempt to save the flopped launch of Fallout 76 will bear any fruit.

That's because on April 7, Bethesda is launching the Wastelanders expansion, a supposedly massive free overhaul that adds -- among many other standard expansion components -- a huge change for the world of Fallout 76: non-player characters.

"We learned from launch was that there was a lot to do, but what we needed for a lot of our audience was to bring the humanity back"

If it seems odd that an open world game in a series known for its characters and writing might launch without any NPCs to support its world-building or quests, yeah, everyone else thought so too. The game launched in late 2018 to criticism for being "soulless," lacking a "strong focus," and "boring" -- problems which were all tied in some way to the lack of in-world characters with stories and stakes to provide motivation. While all the other additions included with Wastelanders -- new locations, enemies, equipment, and quests -- will likely improve Fallout 76's chances, lead designer Ferret Baudoin feels the NPCs are the most important key to righting the ship.

"There was quite a lot that worked at launch," he says at Bethesda's PAX East fan event. "If you're a person who liked exploration, for example, from our traditional games, it was possibly one of the best worlds to explore that we've ever had. It was just huge, full of stories and stuff like that. But there was a large portion of our audience that wanted people. They wanted an emotional connection. And if you know everyone is dead, and you come across a holotape from someone, it loses that hope that you might meet that person and help them out.

"I think what we learned from launch was that core combat was fun, it was great to explore, there was a lot to do, but what we needed for a lot of our audience was to bring the humanity back."

Baudoin acknowledges the humorous contradiction of needing computer-controlled NPCs to provide "human" experiences, but he adds that Fallout 76 isn't totally devoid of humanity. Because players only have one another to interact with, he says, the team has seen all sorts of unusual and uniquely human stories unfold just from players interacting in strange and often wonderful ways.

"The funny thing is that in some respects [the players] added the most human things of all," he says. "The role-playing, for example, or some of the stories you hear about people dressed up as Santa Claus giving out gifts. That was something we didn't anticipate.

"We had whole plans for ways to let players murder each other, and they just wouldn't do it"

"We had all these plans for PvP, and actually, we have the least PvP audience ever. We had whole plans for ways to let players murder each other, and they just wouldn't do it. We have a weird, wonderful audience that would rather help each other out even when they have the other options."

Baudoin is also candid about launching the game without a world full of characters not being the best decision. Had the team known what the response would have been at the time, he admits, they would have included more of what's coming in Wastelanders in the launch version of the game. But because of Fallout 76's relative novelty, Baudoin doesn't think there was any way the team could have known that not having NPCs would be so frustrating.

"At the time, there was no clear analog to what we were making," he says. "So it was very tricky, because you would make arguments as to what you think the game should be, but there was no clear right decision.

"As soon as we saw what people were saying, there was a real fire in the belly to say, 'No, we can address this.' If we solve these problems, there's a whole package here that is very enticing to people, and we just need to provide that extra step... It's far more of a Bethesda experience than we were at launch."

"At the time, there was no clear analog to what we were making"

Because it's such a well known series, Fallout 76 was met with rapid, vocal disapproval at launch. There have been plenty of suggestions across forums and social media outlets for how to improve the game, and while Baudoin says he tries to read as many of them as possible -- he checks one particular popular message board at least twice a day for feedback -- there's a degree of filtering that takes place when the team designs what to change, and how.

"In some respects, our own internal team makes suggestions which are mirrored by the community. We're experts at dealing with that. But you can definitely notice trends.

Originally, Fallout 76 was empty, with the player character the first to leave the vault after a nuclear apocalypse. But in Wastelanders, new faces arrive from outside Appalachia

"Neil Gaiman has that quote, 'When people tell you something's wrong or doesn't work for them, they are almost always right. When they tell you exactly what they think is wrong and how to fix it, they are almost always wrong.' If there's an itch somewhere and it's bugging people, it's our job to figure out as experts how we can address the problem. Sometimes communities get it right, but you have to think of the millions of factors that go into that and make the best decision to address the problem that makes the itch go away and doesn't create further itches down the road."

"This is one of the first times I've been able to, before launch, see what people are reacting to and course-correct"

Later on, he adds:

"As a developer this is one of the first times I've been able to, before launch, see what people are reacting to and course correct. It's been fantastic."

Because the Wastelanders update is free, Baudoin is optimistic that a good chunk of the community that bought the game over a year ago will make their way back to see what's changed. He's hopeful, too, that an overarching love for the Fallout series among the community will keep them in the game.

"I think [Wastelanders] looks a lot more like a traditional Fallout game," he says. "The tagline in my head a lot of the time is: 'Fallout 76 is Fallout with friends.' I think now we've added more of the Fallout into it, the things you expected from Fallout 3, Fallout 4, are now in there. I think we're more properly delivering on that expectation that some people had."

Though Bethesda isn't revealing anything else new for now, Baudoin says that Wastelanders won't be the end of the team's work on Fallout 76. He describes the game as "a chance to tell an evolving story," with those opportunities only expanded by the addition of the characters and plotlines of this new update.

"You have to take risks," Baudoin says. "You have to reach for the stars sometimes. Sometimes you'll fall short, but if you don't, if you lack that ambition, the game is going to feel flatter. It's not going to be as interesting. Some of the things we've done...at the time sounded insane, but then we worked on it and we did it and lo and behold it really works. If we hadn't been willing to take that risk, it wouldn't've been there."

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Anti-Senescence Therapy Market Growth, Sales, Trends, Supply, Forecast By 2026|Unity Biotechnology, Siwa Therapeutics, Calico LLC – Weekly Wall

Los Angeles, United State Complete study of the global Anti-Senescence Therapy market is carried out by the analysts in this report, taking into consideration key factors like drivers, challenges, recent trends, opportunities, advancements, and competitive landscape. This report offers a clear understanding of the present as well as future scenario of the global Anti-Senescence Therapy industry. Research techniques like PESTLE and Porters Five Forces analysis have been deployed by the researchers. They have also provided accurate data on Anti-Senescence Therapy production, capacity, price, cost, margin, and revenue to help the players gain a clear understanding into the overall existing and future market situation.

Key companies operating in the global Anti-Senescence Therapy market include _Unity Biotechnology, Siwa Therapeutics, Calico LLC, AgeX TherapeuticsInc, Numeric Biotech, Human Longevity, Inc. (HLI), Cleara Biotech, OisinBiotechnologies, Recursion Pharmaceuticals, Sierra Sciences, Proteostasis Therapeutics, Senolytic Therapeutics, Allergan

Access PDF Version of this Report at: https://www.qyresearch.com/sample-form/form/1493403/global-anti-senescence-therapy-market

Segmental Analysis

The report has classified the global Anti-Senescence Therapy industry into segments including product type and application. Every segment is evaluated based on growth rate and share. Besides, the analysts have studied the potential regions that may prove rewarding for the Anti-Senescence Therapy manufcaturers in the coming years. The regional analysis includes reliable predictions on value and volume, thereby helping market players to gain deep insights into the overall Anti-Senescence Therapy industry.

Global Anti-Senescence Therapy Market: Types of Products- Gene TherapyImmunotherapyOthers

Global Anti-Senescence Therapy Market: Applications- Cardiovascular DiseasesNeural Degenerative DiseasesOphthalmology DisordersOthers

Competitive Landscape

It is important for every market participant to be familiar with the competitive scenario in the global Anti-Senescence Therapy industry. In order to fulfil the requirements, the industry analysts have evaluated the strategic activities of the competitors to help the key players strengthen their foothold in the market and increase their competitiveness.

Key companies operating in the global Anti-Senescence Therapy market include _Unity Biotechnology, Siwa Therapeutics, Calico LLC, AgeX TherapeuticsInc, Numeric Biotech, Human Longevity, Inc. (HLI), Cleara Biotech, OisinBiotechnologies, Recursion Pharmaceuticals, Sierra Sciences, Proteostasis Therapeutics, Senolytic Therapeutics, Allergan

Key questions answered in the report:

Request Customization of Report: https://www.qyresearch.com/customize-request/form/1493403/global-anti-senescence-therapy-market

Major Table of Contents:-

Executive Summary

1 Industry Overview of Anti-Senescence Therapy

1.1 Definition of Anti-Senescence Therapy

1.2 Anti-Senescence Therapy Segment by Type

1.3 Anti-Senescence Therapy Segment by Applications

1.4 Global Anti-Senescence Therapy Overall Market

1.4.1 Global Anti-Senescence Therapy Revenue (2014-2025)

1.4.2 Global Anti-Senescence Therapy Production (2014-2025)

1.4.3 North America Anti-Senescence Therapy Status and Prospect (2014-2025)

1.4.4 Europe Anti-Senescence Therapy Status and Prospect (2014-2025)

1.4.5 China Anti-Senescence Therapy Status and Prospect (2014-2025)

1.4.6 Japan Anti-Senescence Therapy Status and Prospect (2014-2025)

1.4.7 Southeast Asia Anti-Senescence Therapy Status and Prospect (2014-2025)

1.4.8 India Anti-Senescence Therapy Status and Prospect (2014-2025)

2 Manufacturing Cost Structure Analysis

2.1 Raw Material and Suppliers

2.2 Manufacturing Cost Structure Analysis of Anti-Senescence Therapy

2.3 Manufacturing Process Analysis of Anti-Senescence Therapy

2.4 Industry Chain Structure of Anti-Senescence Therapy

3 Development and Manufacturing Plants Analysis of Anti-Senescence Therapy

3.1 Capacity and Commercial Production Date

3.2 Global Anti-Senescence Therapy Manufacturing Plants Distribution

3.3 Major Manufacturers Technology Source and Market Position of Anti-Senescence Therapy

3.4 Recent Development and Expansion Plans

4 Key Figures of Major Manufacturers

4.1 Anti-Senescence Therapy Production and Capacity Analysis

4.2 Anti-Senescence Therapy Revenue Analysis

4.3 Anti-Senescence Therapy Price Analysis

4.4 Market Concentration Degree

Continued

About Us:

QYResearch always pursuits high product quality with the belief that quality is the soul of business. Through years of effort and supports from huge number of customer supports, QYResearch consulting group has accumulated creative design methods on many high-quality markets investigation and research team with rich experience. Today, QYResearch has become the brand of quality assurance in consulting industry.

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NeoGenomics Reports 40% Revenue Growth to $107 Million in the Fourth Quarter – Yahoo Finance

Fourth-Quarter 2019 Highlights:

Consolidated revenue increased 39.7% to $106.9 million

Clinical Services revenue increased 41.7% to $93.4 million

Pharma Services revenue increased 27.5% to $13.5 million

Pharma Services backlog increased 31.8% to $130.3 million

Company issues 2020 financial guidance

FT. MYERS, FL / ACCESSWIRE / February 27, 2020 / NeoGenomics, Inc. (NEO), a leading provider of cancer-focused genetic testing services, today announced fourth-quarter and full-year 2019 results for the period ended December 31, 2019.

"Our fourth quarter performance concludes a very successful year for NeoGenomics in which our company grew by nearly 50% and our competitive position strengthened dramatically", said Douglas M. VanOort, the Company's Chairman and CEO.

"In the fourth quarter, our Clinical Services Division once again reported excellent volume growth of 27% driven by market share gains and the addition of Genoptix. We are particularly pleased that combined molecular and Next Generation Sequencing test volume continued to grow at rates approximating 50%, and that average-revenue-per-test improved by over 10% from last year. Pharma Services Division growth was also excellent with strong revenue gains, a record amount of newly-signed contracts, and a current backlog of approximately $130 million in signed contracts."

"Perhaps more importantly, we are very excited about the opportunities in front of us. We've made significant investments in a variety of growth initiatives over the past year, including our recent acquisition of the Oncology Division of Human Longevity, Inc., investments in Next Generation Sequencing, and Informatics. We believe that NeoGenomics has significant, sustainable competitive advantages and is well positioned for growth in each of the markets in which we operate."

Fourth-Quarter Results

Consolidated revenue for the fourth quarter of 2019 was $106.9 million, an increase of 40% over the same period in 2018. Clinical test volume(1) increased by 27% year over year. Average revenue per clinical test ("revenue per test") increased by 11% to $370, primarily due to the acquisition of Genoptix and the impact of favorable test mix and growth in next-generation sequencing. Clinical Services revenue was $93.4 million, resulting in a 42% increase over the fourth quarter of 2018. Pharma Services revenue was $13.5 million, which represented a 27% increase over the fourth quarter of 2018.

Story continues

Gross profit improved by $12.8 million, or 34.5%, compared to the fourth quarter of 2018, to $49.9 million. Gross margin decreased by approximately 181 basis points year-over-year to 46.7%. Gross margin decreases are primarily due to the integration of Genoptix. Average cost of goods sold per clinical test ("cost per test") increased by 14% year over year, reflecting the impact of the Genoptix acquisition, including integration-related activities, and test mix. The increase was partially offset by continued efficiencies as we integrate Genoptix.

Operating expenses increased by $13.3 million, or 39%, compared to the fourth quarter of 2018, primarily due to the Genoptix acquisition, investments in research and development, and growth initiatives.

Net income for the fourth quarter was $6.3 million compared to net income of $0.4 million for the fourth quarter of 2018.

Adjusted EBITDA(2) was $13.6 million for the fourth quarter, a 5% improvement from the prior year. Adjusted Net Income(2) was $10.9 million compared to $5.5 million in the fourth quarter of 2018.

Cash and cash equivalents were $173.0 million and days sales outstanding were 81 days at the end of the fourth quarter.

Full Year Results

Consolidated revenues for 2019 were $408.8 million, an increase of 48% over 2018 primarily due to continued volume growth and the acquisition of Genoptix. Net income for 2019 was $8.0 million compared to $2.6 million in 2018. Adjusted EBITDA(2) for 2019 was $57.2 million, a 31% increase from the prior year. Adjusted Net Income(2) for 2019 was $32.3 million compared to $17.9 million in 2018.

2020 Financial Outlook:

The Company also issued 2020 guidance today.

(in millions)

Guidance

Consolidated revenue

$

464 - $474

Net (loss)/income

$

8 - $13

Adjusted EBITDA(2)

$

60 - $65

Please also refer to the tables reconciling forecasted Adjusted EBITDA, Adjusted Net Income and Adjusted Diluted EPS to their closest generally accepted accounting principles ("GAAP") equivalent in the section of this report entitled "Reconciliation of Non-GAAP Financial Guidance to Corresponding GAAP Measures."

The Company reserves the right to adjust this guidance at any time based on the ongoing execution of its business plan. Current and prospective investors are encouraged to perform their own due diligence before buying or selling any of the Company's securities, and are reminded that the foregoing estimates should not be construed as a guarantee of future performance.

(1) Clinical tests exclude tests performed for Pharma Services customers.

(2) The Company has provided adjusted financial information that has not been prepared in accordance with GAAP, including Adjusted EBITDA, Adjusted Net Income, and Adjusted Diluted EPS. Each of these measures is defined in the section of this report entitled "Use of Non-GAAP Financial Measures." See also the tables reconciling such measures to their closest GAAP equivalent.

Conference Call

The Company has scheduled a web-cast and conference call to discuss their fourth quarter and full year results on Thursday, February 27, 2020 at 8:30 AM EST. Interested investors should dial (844) 602-0380 (domestic) and (862) 298-0970 (international) at least five minutes prior to the call. A replay of the conference call will be available until 8:30 AM EDT on March 5, 2020, and can be accessed by dialing (877) 481-4010 (domestic) and (919) 882-2331 (international). The playback conference ID Number is 58948. The web-cast may be accessed under the Investor Relations section of our website at http://www.neogenomics.com. An archive of the web-cast will be available until 08:30 AM EDT on May 27, 2020.

About NeoGenomics, Inc.

NeoGenomics, Inc. specializes in cancer genetics testing and information services. The Company provides one of the most comprehensive oncology-focused testing menus in the world for physicians to help them diagnose and treat cancer. The Company's Pharma Services Division serves pharmaceutical clients in clinical trials and drug development.

Headquartered in Fort Myers, FL, NeoGenomics operates CAP accredited and CLIA certified laboratories in Ft. Myers and Tampa, Florida; Aliso Viejo, Carlsbad, Fresno and San Diego, California; Houston, Texas; Atlanta, Georgia; Nashville, Tennessee; and CAP accredited laboratories in Rolle, Switzerland, and Singapore. NeoGenomics serves the needs of pathologists, oncologists, academic centers, hospital systems, pharmaceutical firms, integrated service delivery networks, and managed care organizations throughout the United States, and pharmaceutical firms in Europe and Asia. For additional information about NeoGenomics, visit http://www.neogenomics.com/.

Forward Looking Statements

Certain information contained in this press release constitutes forward-looking statements for purposes of the safe harbor provisions of The Private Securities Litigation Reform Act of 1995. These forward looking statements involve a number of risks and uncertainties that could cause actual future results to differ materially from those anticipated in the forward-looking statements as the result of the Company's ability to continue gaining new customers, offer new types of tests, integrate its acquisitions and otherwise implement its business plan, as well as additional factors discussed under the heading "Risk Factors" and elsewhere in the Company's Annual Report on Form 10-K filed with the SEC on February 26, 2019, amended by a 10K/A filed with the SEC on May 8, 2019. As a result, this press release should be read in conjunction with the Company's periodic filings with the SEC. In addition, it is the Company's practice to make information about the Company available by posting copies of its Company Overview Presentation from time to time on the Investor Relations section of its website at http://ir.neogenomics.com/.

Forward-looking statements represent the Company's estimates only as of the date such statements are made (unless another date is indicated) and should not be relied upon as representing the Company's estimates as of any subsequent date. While the Company may elect to update forward-looking statements at some point in the future, it specifically disclaims any obligation to do so, even if its estimates change.

For further information, please contact:NeoGenomics, Inc.William BonelloDirector, Investor Relations(239)690-4238 (w) (239)284-4314 (m)bill.bonello@neogenomics.com

NeoGenomics, Inc.

CONDENSED CONSOLIDATED BALANCE SHEETS

(Unaudited, in thousands)

December 31,

2019

December 31,

2018

ASSETS

Cash and cash equivalents

$

173,016

$

9,811

Accounts receivable, net

94,242

76,919

Inventories

14,405

8,650

Other current assets

9,075

8,288

Total current assets

290,738

103,668

Property and equipment (net of accumulated depreciation of $68,809 and $50,127, respectively)

64,188

60,888

Operating lease right-of-use assets

26,492

-

Intangible assets, net

126,640

140,029

Goodwill

198,601

197,892

Other assets

2,847

2,538

TOTAL ASSETS

$

709,506

$

505,015

LIABILITIES AND STOCKHOLDERS' EQUITY

Accounts payable and other current liabilities

$

50,091

$

46,753

Short-term portion of financing obligations

10,432

14,172

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NeoGenomics Reports 40% Revenue Growth to $107 Million in the Fourth Quarter - Yahoo Finance

Research on intermittent fasting shows health benefits – National Institute on Aging

Evidence from decades of animal and human research points to wide-ranging health benefits of intermittent fasting, according to an NIA-conducted review of the research, published in the New England Journal of Medicine. Still, more research is needed to determine whether intermittent fasting yields benefits or is even feasible for humans when practiced over the long term, such as for years.

Intermittent fastingis an eating pattern that includes hours or days of no or minimal food consumption without deprivation of essential nutrients. Commonly studied regimens include alternate day fasting, 5:2 intermittent fasting (fasting two days each week), and daily time-restricted feeding (such as eating only during a six-hour window).

Hundreds of animal studies and scores of human clinical trials have shown that intermittent fasting can lead to improvements in health conditions such as obesity, diabetes, cardiovascular disease, cancers and neurological disorders. The evidence is less clear for lifespan effects. Animal studies have shown mixed results, with sex, food composition, age and genetics among the factors that influence longevity. Human trials have mainly involved relatively short-term interventions and so have not provided evidence of long-term health effects, including effects on lifespan.

The review authors are Rafael de Cabo, Ph.D., of NIAs Intramural Research Program (IRP), and Mark P. Mattson, Ph.D., formerly of NIAs IRP and currently a neuroscientist at the Johns Hopkins University School of Medicine.

Although intermittent fasting often results in reduced calorie consumption, weight loss is not the main driver of the health benefits observed in preclinical and clinical studies, according to the authors. Rather, the key mechanism is metabolic switching, in which fasting triggers the body to switch its source of energy from glucose stored in the liver to ketones, which are stored in fat.

Ketone bodies are not just fuel used during periods of fasting, the authors wrote. They are potent signaling molecules with major effects on cell and organ functions.

Ketogenesis, or the increase of ketones in the bloodstream, initiates activity in a variety of cellular signaling pathways known to influence health and aging. This activity enhances the bodys defenses against oxidative and metabolic stress and initiates the removal or repair of damaged molecules. The impact of ketogenesis carries over into the non-fasting period and can improve glucose regulation, increase stress resistance and suppress inflammation.

Repeated exposure to fasting periods results in lasting adaptive responses that confer resistance to subsequent challenges, the authors explain. The broad-spectrum benefits include not only disease resistance but also improved mental and physical performance.

The authors acknowledge impediments to widespread adoption of intermittent fasting: the ingrained practice in developed nations of three meals a day plus snacks (along with the ready availability and marketing of food), the discipline required to shift to a new eating pattern and the lack of physician training on intermittent fasting interventions. The authors suggest that clinicians who prescribe intermittent fasting encourage their patients to adopt a gradual, phased-in schedule in consultation with a dietitian or nutritionist.

In addition to the question of intermittent fastings long-term effects in humans, the authors point to two other areas requiring further research. Studies are needed to determine whether this eating pattern is safe for people at a healthy weight, or who are younger or older, since most clinical research so far has been conducted on overweight and middle-aged adults. In addition, research is needed to identify safe, effective medications that mimic the effects of intermittent fasting without the need to substantially change eating habits.

This review article and many of the research studies cited within were supported by NIA.

Reference: De Cabo R and Mattson MP. Effects of intermittent fasting on health, aging, and disease. New England Journal of Medicine. 2019;381(26):2541-2551. doi: 10.1056/NEJMra1905136.

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Research on intermittent fasting shows health benefits - National Institute on Aging

County arts council announces ‘Creative Age’ symposium – The Spectrum

Arts and Healing Across the Lifespan serves as the theme of the 4th annual Creative Age symposium organized by the Arts Council of Washington County.

Jeremy Nobel, M.D., founder of the Foundation for Art & Healing (FAH), is Board Certified in both Internal Medicine and Preventative Medicine, with masters degrees in Epidemiology and Health Policy from Harvard School of Public Health, where he serves on the adjunct faculty.(Photo: Arts Council of Washington County)

We have brought together some of the best thinkers in arts therapy for this one-day, intensive symposium, said Paula Bell, chair of the event. So much exciting research shows the proven benefits, regardless of age, of participating in the arts for longevity, mobility, cognitive ability and quality of life for all.

The symposium features two inspiring keynote speakers and 14 breakout sessions, with entertainment from a concert pianist. Bell suggests the symposium is targeted to parents and teachers; psychologists; counselors; doctors; caregivers; arts, music and drama therapists; those working with patients with dementia, Alzheimers and Parkinsons; and those aspiring to understand the loneliness epidemic.

Jeremy Nobel, M.D., founder of the Foundation for Art & Healing (FAH), embodies in a most personal way the effort to enlist art and science in the relief of human suffering. Nobel, who is Board Certified in both Internal Medicine and Preventative Medicine, with masters degrees in Epidemiology and Health Policy from Harvard School of Public Health, where he serves on the adjunct faculty, is also a poet, a photographer, and a teacher a practitioner of the humanities. He is scheduled to attempt to answer the question, Can creative expression be medicine?

Nobel will help participants discover how creative expression reduces the physical and emotional burden associated with various types of health conditions and life circumstances," said Ken Crossley, co-chair of the event.

Nobels Unlonely Project is the signature initiative of FAH, a project whose mission is to broaden public awareness of the negative physical and mental health consequences of loneliness, while promoting creative arts-based interventions to reduce its burden. The project has garnered national visibility, including being featured on the Today Show, The New York Times and Psychology Today. Nobel will present a breakout session, Deep Dive with Jeremy Nobel.

Erica Curtis, certified marriage and family therapist, as well as author, speaker and instructor at UCLArts & Healing, co-authored with Ping Ho, the award-winning book, The Innovative Parent: Raising Connected, Happy, Successful Kids through Art.(Photo: Katie Lubbers)

Erica Curtis, certified marriage and family therapist, as well as author, speaker and instructor at UCLArts & Healing, co-authored with Ping Ho, the award-winning book, The Innovative Parent: Raising Connected, Happy, Successful Kids through Art. As a keynote speaker, Curtis is scheduled to address how art may help parents temper storms of emotion, defuse sibling conflicts, get teeth brushed, and raise happy, successful kids. Her approach has been described as simple, doable and fun.

She believes talking to kids often is not effective, especially when it comes to calming emotions. In her hands-on keynote, Curtis will share art therapy trade secrets to address the countless challenges faced by children and teens when words are inadequate or inaccessible. From anger to anxiety and daily struggles, this session equips the participant with practical tools for calming kids, and is geared toward parents, grandparents, and professionals alike.

Dr. Massimiliano Frani, concert pianist and founder of Genote Health Music, is scheduled to provide entertainment at the Creative Age symposium and will also lead a breakout discussion focused on providing tools to better understand the effects of health music on aging and recovery processes.(Photo: Arts Council of Washington County)

Dr. Massimiliano Frani, concert pianist and founder of Genote Health Music, will provide entertainment on Saturday morning after breakfast and will also lead a breakout discussion focused on providing tools to better understand the effects of health music on aging and recovery processes. Participants may assess health music applications as a non-pharmacological intervention. As master pedagogue, he performs and lectures worldwide about music as medicine and its effects in physical and mental health, education and sports. He has presented Health Music papers, training sessions and conferences worldwide and is the recipient of the Melvin Jones Humanitarian Award.

Other presenters include Vicky Morgan, Victoria Petro-Eschler, Debra Eve, Joni Wilson, Chara Huckins, Dr. Brandt Wadsworth, Barbara Lewis, Nicholas Cendese, Karen Carter, Dr. David Tate, Sharon Daurelle, Emily Christensen, Alex Mack, Saundra Shanti and Rev. Claudia Giacoma.

Bell says the event should havesomething engaging for everyone, including music, dance, art, theater, singing and spiritual care.

This symposium and these workshops are topnotch," Crossley said.

The symposium is slated for Saturday, February 29, 2020, at the Eccles Fine Arts Center on the campus of Dixie State University from 8 a.m. to 5 p.m., with an opening reception in downtown St. George Friday evening from 6 p.m. to 8p.m. at ART Provides Gallery, 35 N.Main Street.

Registration and a light breakfast begin at 7:30 a.m. on Saturday, with lunch at noon, and speakers and workshops continuing until 5p.m. Both meals and symposium materials are included in a registration fee of $50, with seniors and students charged $35. To register for the event, go to http://www.artswashco.com and click on the ticket link.

For a list of hotels and lodging opportunities, additional information and questions, please call 435-238-4948 or email info@engageutah.org.

In addition, participants may earn CEU credits in physical therapy, occupational therapy, recreational therapy, social work and arts and music therapy, with up to seven credits available. Applications are available at the registration desk. CEU credits are available for a $15processing fee, which may be prepaid online or with registration at the door.

JJ Abernathy is an arts advocate and musician, and may be contacted at musictimes05@gmail.com.

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The Calling – Thrive Global

There was something about her face that wrecked me. Her eyes pleaded. Her coat was too small. She looked to be about eight year old. The weather was freezing and she had no socks. Her parents busked nearby for change. A five dollar bill floated in the bottom of my purse and I handed it to the sweet faced young father who smiled and thanked me while he played his guitar.

But I knew it was not enough. I had to do something more. Her face haunted me. How many more children were out there without a home, shuffling from place to place?

The thought would not leave me. Change had to come, I had to respond.

It took a few years, but finally that call was answered.

Quitting my life was not a casual decision. I left my husband of two decades and a year later the career Id had for 30 years was pruned away. Its not that my marriage was bad. It wasnt. Its not that my career in broadcast news was a wreck, it had exceeded my expectations.

Its simply that neither could answer the longing I felt for radical self exploration, change and eventually the desire for what my mother called, full time service. I couldnt go on looking at the suffering around me without responding to it. Writing a check or even occasionally helping out didnt lift the despair or quench the dryness in my psyche.

I felt like my comforts made me miserable. That sounded crazy, but it kept coming back, whispering : Theres more.

More what?

More I could be doing.

Thats often the narrative of profound change.

So on a late fall day I walked trembling to my bosss office in the dimming blue light of a nearly empty office building and dropped off a letter of resignation through the slot in his door. After I did it, I immediately wanted to fish it back out. I thought about finding a hanger and trying, but instead I slid to the floor and cried.

It could not be done. The decision was made.

A month later, goodbye balloons in hand, I planned for recalibration. I got accepted into Roshi Joan Halifaxs Zen Center, Upaya, which translated is skillful means and I learned to sit still, listen to my heart and take instructions on getting over myself.

Lest this sounds like a wealthy womans game, I need to let you know its not. I had no fat bank accounts and no real property. The few things I had, I gave away. While I was sitting in silence my auto pay finished the money in savings so that I didnt have a nickel left.

Terrifying, yes. Necessary, yes.

For me, it was the little girl who exploded my heart into a driving force of love. For you, it may be something else. Listen to it. Research has shown us that helping others not only makes us feel better about ourselves but improves mental health and longevity. We are meant to live in connection to one another, we are built for this purpose.

It doesnt take money to make a difference, and it doesnt take fame and it doesnt take waiting until some later date. What it takes is pushing against the blade of fear until youre sure youll never make it and then discovering that you do make it, that you do find the skill to make your life meaningful at a whole new level.

You do survive. You do help others and in the process you thrive. Not every day, because service is not a fantasy. Waiting for someone else, imagining a different person will be the hero is the actual fantasy. You are the person called to do the work of service, and you can.

So whats my big thing? How do I serve?

I house homeless families with children. Our Homes lovingly provide private sleeping nooks for kids, full kitchens and baths and a private master bedroom for parents.

By converting school buses into fully equipped and quite beautiful tiny homes on wheels, young families can be housed permanently and even move for better opportunities without fearing a loss of home.

I dreamed about it for months and then one day wrote a blog expressing my dream. A woman I had never met contacted me and funded our first two home conversions. We started a non profit and I met Arianna Huffington on The Kelly Clarkson Show a year later.

We awarded our first converted bus to a homeless family with children. I see them often. In fact just the other day the two oldest children in the family waved sweetly from their car as we passed each other in traffic. They used to sleep in that car, now they take it on field trips just like other kids do.

Wherever your passion lies in helping, that is where your future is waiting. For some it is in non-human animals, for others it may be racial justice and for some it can be checking in on your aging neighbor or offering a hand to a kid who needs a drivers ed teacher. You may want to do this full time or on the side. Any way you can help others joyfully is your nexus of truth.

I am not happy every day and sometimes I still struggle to keep food on my own table. There is no promise with service that your life will be easy. There is only the promise that you will try. You will try to help. You will commit to that effort and in your commitment, you will thrive.

If youre in service or know someone who is, please reach out and Ill do my next column about that in the weeks to follow. Reach me at [emailprotected]

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The Calling - Thrive Global

Vatican Round Up – The Irish Catholic

Uruguayan priest named the Popes new Personal Secretary

Fr Gonzalo Aemilius has been elected as Pope Francis new Special Secretary, filling the void left by Father Fabian Pedacchio in December.

The clergyman from Montevideo, Uruguay has been known to the Pope since 2006 when Cardinal Jorge Mario Bergoglio, Archbishop of Buenos Aires, endorsed him for his work with street children.

Fr Aemilius, a Doctor of Theology, was ordained a priest in May 2006 and takes over from Argentine priest Fr Pedacchio, who served alongside Pope Francis from 2013 to 2019.

The incoming secretary credited his predecessors ability to integrate different values and channel them in a single direction, saying that it had struck him deeply.

Experiencing this ability of his was decisive in my life, he said of Archbishop Bergoglio. He taught me to take the best that is in each individual, however different he or she may be from others, and to put it to good use for the good of all.

The Uruguayan priest chosen by Pope Francis will accompany his current Personal Secretary, Fr Yoannis Lahzi Gaid.

Modern society is progressively eroding the understanding of that which makes human life precious, according to Pope Francis in an address to the Congregation for the Doctrine of the Faith.

The Holy Father spoke about the intangible value of human life, of care for the terminally ill and of the need to rewrite the grammar of responsibility and caring for those who are suffering.

He said that in contemporary times, lives that are seen as no longer useful are considered unworthy or to be discarded, devoid of authentic value.

Pope Francis warned there is danger of losing the imperative duty of solidarity, and of human and Christian fraternity.

He insisted that we must never abandon anyone in the presence of incurable illness. Human life, he continued, because of its eternal destiny, maintains all its value and all its dignity in whatever condition.

Old-age is a precious treasure that takes shape in the journey of every man and womans life, said Pope Francis at an audience for participants in a conference on pastoral care of the elderly.

Life is a gift, and when it is long it is a privilege, for oneself and for others. Always.

The Pope called on the Church to care for the elderly, going to them with a smile on your face and the Gospel in your hands.

He noted that the world is facing a significant demographic change, with fewer young people and a large increase in the number of elderly.

He said that issues facing the elderly including social disorientation, and societal attitudes of indifference and rejection, are a call to the Church and to society to serious reflection in order to learn to grasp and appreciate the value of old age.

He reminded us that, in the Bible longevity is a blessing, and that the elderly, too, have a place in Gods saving plan.

Both old and young, he said, are the future of the Church.

Related

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Vatican Round Up - The Irish Catholic

Anti-Senescence Therapy Market- A comprehensive assessment of current dynamics and emerging avenues – News Parents

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Anti-Senescence Therapy Market- A comprehensive assessment of current dynamics and emerging avenues - News Parents

Origins and insights into the historic Judean date palm based on genetic analysis of germinated ancient seeds and morphometric studies – Science…

INTRODUCTION

The date palm (Phoenix dactylifera), a dioecious species in the Arecaceae (formerly Palmae) family has a historical distribution stretching from Mauritania in the west to the Indus Valley in the east (1). A major fruit crop in hot and arid regions of North Africa and the Middle East and one of the earliest domesticated tree crops, archaeobotanical records suggest that the earliest exploitation and consumption of dates is from the Arabian Neolithic some 7000 years before the present (yr B.P.) (1). Evidence of cultivation in Mesopotamia and Upper Arabian Gulf approximately 6700 to 6000 yr B.P. support these centers as the ancient origin of date palm domestication in this region, with a later establishment of oasis agriculture in North Africa (1, 2).

The current date palm germplasm is constituted by two highly differentiated gene pools: an eastern population, consisting of cultivars extending from the Middle East and Arabian Peninsula to northwest India and Pakistan and a western population covering North Africa and sub-Saharan Africa (3, 4). Introgressive hybridization by a wild relative in North African date palms has been proposed as a source of this differentiation (2).

Date palms in the southern Levant (modern-day Israel, Palestine, and Jordan), situated between eastern and western domestication areas, have historically played an important economic role in the region and were also of symbolic and religious significance (5). The Kingdom of Judah (Judea) that arose in the southern part of the historic Land of Israel in the 11th century BCE was particularly renowned for the quality and quantity of its dates. These so-called Judean dates grown in plantations around Jericho and the Dead Sea were recognized by classical writers for their large size, sweet taste, extended storage, and medicinal properties (5). While evidence suggests that Judean date culture continued during the Byzantine and Arab periods (4th to 11th century CE), further waves of conquest proved so destructive that by the 19th century, no traces of these historic plantations remained (5).

In 2008, we reported the germination of a 1900-year-old date seed (6) recovered from the historical site of Masada overlooking the Dead Sea. In the current study, six additional ancient date seeds from archaeological sites in the Judean desert were germinated, bringing to seven the number of ancient genotypes genetically analyzed using molecular markers. In addition, morphometric analysis was used to compare the size and shape of ungerminated ancient date seeds with modern varieties and wild dates.

This study, which confirms the long-term survival of date palm seeds, provides a unique opportunity to rediscover the origins of a historic date palm population that existed in Judea 2000 years ago. The characteristics of the Judean date palm may shed light on aspects of ancient cultivation that contributed to the quality of its fruit and is thus of potential relevance to the agronomic improvement of modern dates.

Of the hundreds of ancient date seeds and other botanical material recovered from excavations carried out in the Judean desert between 1963 and 1991 (7, 8) (fig. S1), 32 well-preserved date seeds from the archaeological sites of Masada, Qumran, Wadi Makukh, and Wadi Kelt were planted in a quarantine site at Kibbutz Ketura (table S1). Of these, six ancient seeds germinated and were further identified by the following monikers: Masada: Adam; Qumran: Jonah, Uriel, Boaz, and Judith; and Wadi Makukh: Hannah (Figs. 1 and 2).

(A) Adam, (B) Jonah, (C) Uriel, (D) Boaz, (E) Judith, (F) Hannah, and (G) HU37A11, an unplanted ancient date seed from Qumran (Cave FQ37) used as a control. Scale bars, 0.5 cm (A, no bar size as unmeasured before planting). Photo credit: Guy Eisner.

Ages in months at time of photograph (A to C) Adam (110 months), Jonah (63 months), and Uriel (54 months). (D to F) Boaz (54 months), Judith (47 months), and Hannah (88 months). Photo credit: Guy Eisner.

On visual inspection, no specific observation linked the ability of these seeds to germinate compared with those that failed to germinate. Before planting, the ancient date seeds had been weighted, and their length was measured, with the exception of those seeds from Masada, (including Adam, the germinated seed), which unfortunately were not measured (table S1). No statistically significant differences were found between germinated and ungerminated seeds in either weight {1.67 0.55 and 1.61 0.29 g, respectively [Students t test (t) = 0.348, degree of freedom (df) = 24, P = 0.731]} or length [27.60 3.7 and 26.8 3.7 mm, respectively (t = 0.455, df = 24, P = 0.653)].

Radiocarbon ages are shown (Fig. 3 and table S2) for ancient date seeds germinated in the current study and also for the date seed (seed 3/Methuselah) germinated in our previous work (6). These ages were obtained from seed shell fragments found clinging to the rootlets of germinated seedlings during their transfer into larger pots (3 to 17 months of age). The values were recalculated to take into account contamination by modern carbon incorporated during seedling growth previously shown to reduce measured radiocarbon age by approximately 250 to 300 years, equivalent to 2 to 3% modern carbon (table S2) (6). On the basis of these calculations, Methuselah germinated in our previous study (6) and Hannah and Adam in the current study are the oldest samples (first to fourth centuries BCE), Uriel and Jonah are the youngest (first to second centuries CE), and Judith and Boaz are intermediate (mid-second century BCE to mid-first century CE) (Fig. 3).

Eighteen ancient date seeds that failed to germinate were recovered from the potting soil and compared with modern seeds derived from 57 current date palms of which 48 are cultivated varieties and 9 are wild individuals (9, 10). Ancient seeds were significantly larger in terms of both length and width (length, 27.62 3.96 mm; width, 10.38 0.71 mm) than both current cultivar (length, 20.60 4.70 mm; width, 8.33 1.02 mm) and wild date palm seeds (length, 16.69 3.39 mm; width, 7.08 0.46 mm) (Fig. 4). Ancient seeds were, on average, 27.69% wider (t = 11.923, df = 18.391, P = 2.157 1010) and 38.37% longer than the combined current samples (wild and cultivated) (t = 7.422, df = 17.952, P = 3.564 107).

Length (millimeters) (left) and width (millimeters) (right) of ancient date seeds that failed to germinate (n = 18), 9 current wild individuals (n = 180), and 48 cultivated P. dactylifera varieties (n = 928). Letters a, b, and c above boxes indicate Tukeys groups derived from HSD.test function and R package agricolae.

When only compared to the cultivars, the ancient date seeds were still larger: 24.55% wider (t = 11.923, df = 18.391, P = 2.157 1010) and 34.06% longer (t = 7.422, df = 17.952, P = 3.564 107). However, the contrast in seed size is even more marked when comparing ancient seeds and current wild date palms: The Judean date palm seeds were, on average, 39.55% wider (t = 19.185, df = 18.471, P = 5.943 1014) and 65.48% longer than current wild samples (t = 11.311, df = 19.574, P = 2.472 1010) (tables S3 and S4).

Analysis of seed shape diversity in current and ancient date seeds using principal components analysis (PCA) (dudi.pca function) performed on seed outlines confirmed visual observation that modern cultivated seeds were more diverse in size than ancient ones but did not differentiate between the two groups [multivariate analysis of variance (MANOVA), P > 0.05]. Ancient seeds displayed an elongated shape similar to current cultivated samples (fig. S2).

The sex of the six germinated ancient date seedlings in the current study identified using three sex-linked simple sequence repeats (SSR) (11) were as follows: Judith and Hannah are female genotypes and Uriel, Jonah, Boaz, Adam, and Methuselah (seed 3) from the previous study (6) are male genotypes. Through microsatellite genotyping, three levels of genetic inheritance were investigated to highlight geographic origins (Fig. 5, A and B): (i) inheritance transmitted by both parents to progeny, obtained by microsatellite markers showing western and eastern patterns of the ancient seeds genomes (4), as presented in structure analysis and pie charts (Fig. 5A); (ii) inheritance transmitted from mother to progeny through the chloroplast genome, reflecting maternal lineage origin by reporting chloroplastic minisatellite eastern or western alleles (Fig. 5B, arrow) (12); and (iii) inheritance transmitted from father to son through the Y chromosome, reflecting paternal lineage origin by reporting male specific sex-linked eastern or western alleles (Fig. 5B, arrow) (11).

(A) Structure analysis results are shown for modern and ancient western (green) and eastern (orange) genotype contributions. Pie charts highlight eastern (orange) and western (green) ancient seeds nuclear genomes contributions. (B) Ancient seeds maternal and paternal lineages origin. Arrows represent clonally transmitted parental information, with maternal (chloroplastic) and paternal (Y chromosome) from western (green) and eastern (orange) origins.

Structure analysis revealed that distribution of the germinated ancient date seeds was within previously described eastern and western date palm gene pools (Fig. 5A). Methuselah, Hannah, and Adam are the most eastern genotypes, although they also show ancient western contributions requiring numerous generations and highlighting ancient crosses. Boaz and Judith are the most admixed, with almost equal eastern and western contributions reflecting more recent crossings. Jonah and Uriel are the most western genotypes with the most western parental lineages (Fig. 5B).

To shed light on genetic diversity of the ancient dates, basic population genetic parameters were estimated and compared to modern reference collections (tables S5 and S6). The ancient genotypes showed an allelic richness value (Ar) (i.e., the number of alleles) of 3.59, a relatively high diversity for such a small sample size (seven genotypes) compared to values of other countries sampled (table S6). Genetic relationships between the ancient date and current varieties (Fig. 6 and table S7) show Methuselah and Adam close to eastern modern varieties Fardh4 and Khalass, respectively, assigned to current Arabian Gulf varieties; Hannah and Judith related to modern Iraqi varieties Khastawi and Khyara, respectively; and Uriel, Boaz, and Jonah, the most western genotypes, related to modern Moroccan varieties, Mahalbit, Jihel, and Medjool, respectively.

Modern varieties from United Arab Emirates (light orange), Iraq (red), Tunisia (blue), Morocco (light green), Egypt (dark green), and ancient genotypes (purple).

In the current study, six ancient date seeds, in addition to the seedling obtained in our previous study (6), were germinated. All the seeds were approximately 2000 years old and had been previously recovered from archaeological sites in the Judean desert, a rain shadow desert of ca. 1500 km2 located between the maquis-covered Judean Hills and the Dead Sea (fig. S1).

Little is known about the mechanisms determining seed longevity; however, it has been related to the ability to remain in a dry quiescent state (13). In the current study, low precipitation and very low humidity around the Dead Sea could have contributed to the longevity of the ancient date seeds, which may be an adaptation of date palms to extreme desert conditions fostering seed dispersion. Their remarkable durability, however, may also be connected to other extreme environmental conditions in this area; at 415 m below mean sea level, the Dead Sea and its surroundings have the thickest atmosphere on Earth, leading to a unique radiation regime and a complex haze layer associated with the chemical composition of the Dead Sea water (14). However, since no visible evidence in the current study was linked to seed germination and, accordingly, to their long term survival, further investigations are needed to understand the basis of date palm seed longevity.

Among the worlds oldest cultivated fruit trees, P. dactylifera is the emblematic of oasis agriculture and highly symbolic in Muslim, Christian, and Jewish religions (5). Closely connected to the history of human migrations, the first cultivated varieties of P. dactylifera are thought to have originated around Mesopotamia and the Upper Arabian Gulf some 6700 to 6000 yr B.P. (1, 2, 10). In Judea, an ancient geopolitical region that arose during the 11th century BCE in the southern part of the historic Land of Israel, and situated at the cross roads of Africa, Asia, and Europe, the origins of date palm cultivation are unknown. However, from historical records, a thriving Judean date culture was present around Jericho, the Dead Sea, and Jordan Valley from the fifth century BCE onward, benefitting from an optimal oasis agriculture environment of freshwater sources and subtropical climate (5).

Described by classical writers including Theophrastus, Herodotus, Galen, Strabo, Pliny the Elder, and Josephus, these valuable plantations produced dates attributed with various qualities including large size, nutritional and medicinal benefits, sweetness, and a long storage life, enabling them to be exported throughout the Roman Empire (5, 15, 16). Several types of Judean dates are also described in antiquity including the exceptionally large Nicolai variety measuring up to 11 cm (5, 15, 16).

In the current study, ancient seeds were significantly longer and wider than both modern date varieties and wild date palms. Previous research has established that both fruits and seeds are larger in domesticated fruit crops compared with their wild ancestors (17), suggesting that the ancient seeds were of cultivated origin (9, 18), most likely originating from the regions date plantations. Furthermore, an increase in seed size has been linked allometrically to an increase in fruit size (19), corroborating the historical descriptions of the large fruits grown in this region.

Genotypes of the germinated ancient date seedlings cover a large part of present-day date palm distribution area, findings that reflect the variety, richness, and probable influences of the historic Judean date groves. Microsatellite genotyping shows a relatively high diversity, with eastern and western gene pool contributions, allelic richness, and genetic proximity to current varieties cultivated in the Arabian Peninsula, Iraq, and North Africa. Although the sample size is small, a predominance of eastern female lineages (six of seven) indicates that eastern female varieties grown from local germplasm were probably clonally propagated from offshoots to maintain desirable fruit qualities. Male lineages, mainly western (four of five), suggest that genetically different or foreign males were used for pollination. This assumption is supported by first century texts, indicating that substantial knowledge existed in ancient Judea 2000 years ago regarding the most suitable males for pollination of female date palms (20).

Our results reinforce the historical narrative that a highly sophisticated domestication culture existed in ancient Judea. Local farmers with an interest in maintaining genetic diversity in their date plantations and anthropogenic pressures leading to selection on fruit dimension and other desirable traits used cross-breeding with foreign (genetically different) males to develop a rich collection of varieties.

These findings suggest that Judean date culture was influenced by a variety of migratory, economic, and cultural exchanges that took place in this area over several millennia.

In Israel, the oldest remains of P. dactylifera are wood specimens 19,000 yr B.P. from Ohalo II site on the Sea of Galilee (21). Recovery of carbonized date seeds from Chalcolithic and Early Bronze Age sites (4500 to 2900 BCE) in the Judean desert, Jordan Valley, and Jericho (22, 23) and early Iron Age sites in Israel (12th to 11th century BCE) (24) suggest that human exploitation and consumption of dates occurred at this time. However, it is unclear whether these samples, which are relatively few in number and of very small size (22, 25, 26), are derived from ancient wild populations, as suggested by morphometric studies of modern wild date populations (18) or represent an early stage of the domestication process.

In the current study, although the sample size is too small to claim a trend, on a gradient from east to west genetic contributions, the older the germinated seeds are on radiocarbon dating (Fig. 3), the more eastern is the nuclear genome (Fig. 5, A and B ). In this respect, Methuselah, Adam, and Hannah (first to fourth centuries BCE) have a predominantly eastern nuclear genome and eastern maternal lineage, their relationship to modern varieties from the Arabian Gulf and Iraq suggesting that they belong to the same eastern genetic background.

The P. dactylifera cultivated by the inhabitants of Judea at that time therefore appears to be from the eastern gene pool, possibly growing locally and related to oasis populations, of which relict populations were recently found in Oman (9).

Elite female cultivars may also have been introduced to ancient Israel from these regions, consistent with a pattern of human intervention and possibly active acquisition of date palm varieties. Established trade links are documented with Arabia and the Persian Gulf from at least the 12th century BCE (27). Babylonian date palm cultivation in southern Mesopotamia (most of modern Iraq), originating some 6000 yr B.P. (1, 2), used deportees from ancient Judea following its conquest in the sixth century BCE (28). After the collapse of the Neo-Babylonian Empire, returning exiles may have brought this specialized knowledge and selected cultivars back to Judea; a date variety Taali cultivated in both Judea and Babylon is mentioned in the Talmud (29).

Western genetic admixtures in the germinated seedlings and their proximity to current cultivated date varieties from Morocco also suggest that ancient Judean date palms were the result of germplasm exchanges with this area and of multiple crosses. Introgression of eastern genomes into western ones are common, detected in varieties from Algeria, Morocco, Mauritania, and particularly east-west junction areas like Egypt (1, 2, 4, 30). In the latter, eastern contributions from the Persian Gulf, detected in ancient Egypt date seeds from 1400 BCE to 800 CE, reveal a chronological pattern of change in agrobiodiversity and the possible emergence of a western form in the Roman period (10).

Introgression of date palm western genomes into eastern ones, however, is far lower (1, 2, 4, 12), their presence in the current study reflecting west to east exchanges.

The origins of these exchanges are unclear; however, archaeological evidence indicates that North Africa, Near East, and Mediterranean cultures were clearly linked during the Neolithic in the southern Levant (approximately 11,700 to 7300 B.P.) and were associated in Jericho with the earliest origins of food production and fundamental changes in human subsistence strategies (31).

Phoenicia, a maritime trading nation occupying the coastal areas of modern northern Israel, Lebanon, and Syria (1500 to 300 BCE), was also historically associated with cultivation and trade of date palms (32). We can speculate that later west to east germplasm exchanges to this region may have been associated with domesticated varieties originating in Phoenician City States in North African (e.g., Carthage in present-day Tunisia) (32), where oasis agriculture appeared relatively late in the archaeological record (3).

The most western genotypes in the current study (Uriel and Jonah) are also the youngest seeds (mid-first to mid-second CE), coinciding with established trade routes linking this region to North Africa and supporting evidence for date consumption in the latter 2000 years ago (2, 3). This period coincides with Judeas well-documented wars against Rome (66 to 73 CE and 132 to 136 CE) and deportation and displacement of its population (16). The ancient seeds in the current study were found in the Judean desert, historically a place of refuge due to its steep cliffs and inaccessible caves (16, 23). The loss of political autonomy and the final collapse of Judea have been postulated as causing major disruption to labor intensive practices associated with date cultivation (33). Elite cultivars no longer conserved by vegetative propagation (offshoots) were gradually replaced by seedling date palms producing fruits displaying considerable variation within the progeny. Although P. dactylifera can live for more than 100 years (33) and date groves in this region are thought to have persisted for several more centuries, they were already rare by the 11th century and had been entirely replaced by seedling populations or feral, wild trees producing only low-quality fruit (5, 33), by the 19th century.

The current study sheds light on the origins of the Judean date palm, suggesting that its cultivation, benefitting from genetically distinct eastern and western populations, arose from local or introduced eastern varieties, which only later were crossed with western varieties. These findings are consistent with Judeas location between east-west date palm diversification areas, ancient centers of date palm cultivation, and the impact of human dispersal routes at this crossroads of continents.

Given its exceptional storage potentialities, the date palm is a remarkable model for seed longevity research. Investigations on the molecular mechanisms involved in long-term protection in the dried state have important implications on plant adaptation to changing environments and for biodiversity conservation and seed banking. As new information on specific gene-associated traits (e.g., fruit color and texture) (3) is found, we hope to reconstruct the phenotypes of this historic date palm, identify genomic regions associated with selection pressures over recent evolutionary history, and study the properties of dates produced by using ancient male seedlings to pollinate ancient females. In doing so, we will more fully understand the genetics and physiology of the ancient Judean date palm once cultivated in this region.

The objectives of this study and its design were as follows:

1) The origin and selection of ancient date seeds derived from archaeological sites in the Judean desert.

2) The germination of ancient date seeds in a quarantine site following a preparatory process.

3) Radiocarbon dating and recalculation of calendar ages of germinated ancient date seeds based on seed shell fragments and selected controls.

4) Seed morphometric studies: Comparing ungerminated ancient date seeds with seeds from modern date varieties and wild date palms.

5) Microsatellite analysis of seven germinated date seedlings.

(statistical methods are included in the respective sections)

The ancient date seeds in the current study were obtained from botanical material recovered from archaeological excavations and surveys carried out at the following sites in the Judean desert between 1963 and 1991 and stored at room temperature since their discovery (fig. S1).

1) Masada: An ancient fortress/palace complex built by King Herod the Great (37 to 4 BCE) at the southern end of the Dead Sea on the site of an earlier Hasmonean fortification (141 to 37 BCE) (7). The site, built on a plateau approximately 400 m above the Dead Sea, was first excavated by the late Y. Yadin (Institute of Archaeology, Hebrew University, Jerusalem, Israel) from 1963 to 1965 (7). Bioarchaeological material found at this time included large numbers of date seeds buried under rubble close to the remains of an area identified as a food storage site.

2) Qumran: An archaeological site situated at the northern end of the Dead Sea including an ancient settlement dating from the second century BCE destroyed in 68 CE and a number of caves located in the surrounding cliffs and marl terrace associated with the 1947 discovery of the Dead Sea Scrolls. Later excavations and surveys of caves in this area, carried out from 1986 to 1989, by J. Patrich and B. Arubas (The Institute of Archaeology, The Hebrew University, Jerusalem, Israel) (8) included the following: Qumran Cave 13: artifacts found included potsherds from period 1b Qumran (until 31 BCE), numerous date stones and dried dates in a pit, and a pottery juglet dated to approximately 67 to 79 CE containing an unknown viscid substance and wrapped in palm fibers (used as a control in radiocarbon analysis in the current study) (see below); and Qumran Cave FQ37: containing a number of date stones and first to second CE century artifacts from the late Second Temple period (60 to 70 CE) and Roman period.

3) Wadi Makukh: A winter water channel in the Judean desert surrounded by high cliffs and containing a number of caves, which were surveyed from 1986 to 1989 (above). Date seeds found in caves 1, 3, 6, and 24 in this area were included in the current study; Cave 1 was found to include a Chalcolithic burial site (fifth millennium B.P.) containing human skeletons as well as Roman period artifacts but with signs of considerable disturbance by grave robbers (8).

4) Wadi Kelt: A winter water channel running from Jerusalem to the Dead Sea containing a number of caves (8). Date seeds from Masada were provided to S.S. by M. Kislev (Faculty of Life Sciences, Bar Ilan University), initially in 2005 (6) and again in 2007 (germinated in the current study), following permission by the late E. Netzer (Department of Archaeology, Hebrew University of Jerusalem). Date seeds from Qumran, Wadi Makukh, and Wadi Kelt were provided to S.S. by J. Patrich in 2009.

Out of a collection of many hundreds of ancient date seeds, a total of 34 were selected for the current study based on the specimens appearing visually to be intact whole seeds, in good condition, and without holes. They included Masada (8 seeds), Qumran (18 seeds), Wadi Makukh (7 seeds), and Wadi Kelt (1 seed). Ancient date seeds selected above were identified by code numbers and photographed, and measurements of weight and length were made before planting (with the exception of Masada seeds, which unfortunately were not measured) (table S1). One date seed, from the Qumran excavations (HU 37 A11), was selected as a control and left unplanted (table S1).

The remaining 33 seeds were subjected to a preparatory process to increase the likelihood of seed germination using the following established methods to sprout delicate germplasm (34): seeds were initially soaked in water for 24 hours and in gibberellic acid (5.19 mM) (OrthoGrow, USA) for 6 hours to encourage embryonic growth. This was followed by Hormoril T8 solution (5 g/liter) (Asia-Riesel, Israel) for 6 hours to encourage rooting and KF-20 organic fertilizer (10 ml/liter) (VGI, Israel) for 12 hours. All solutions were maintained at 35C.

Following the above procedure, one seed was found to be damaged and not planted. The remaining 32 seeds were separately potted in fresh sterile potting soil, 1 cm below the surface, and placed in a locked quarantine site at the Arava Institute of Environmental Sciences, Kibbutz Ketura, located in the southern Israel. Eight weeks after germination and periodically afterward, KF-20 (10 ml/liter) and iron chelate (10 g/liter) were added to the seedlings. Irrigation used desalinated water, as our previous study on germinating the first ancient date seed (6) indicated that using the regions highly mineralized water produced tip burn (darkening and drying of leaves).

Radiocarbon ages in the current study were obtained for the following bioarchaeological material: (i) fragments of seed shell coat found clinging to the rootlets of six germinated ancient date seeds when these seedlings were transferred into larger pots, (ii) an unplanted ancient date seed from cave 37 Qumran (HU37 A11) (used as a control), and (iii) part of an ancient palm frond surrounding an oil juglet found in Qumran Cave 13 (used as a control). Radiocarbon ages of seed shell fragments from the germinated seedlings were recalculated to take into account modern carbon incorporated during seedling growth (6).

1) Methodology: Nonorganic carbon (carbonates) were removed from all samples with 10% HCl under reduced pressure followed by repeated washes in deionized water until neutral (pH 7). Organic acids formed during the rotting process were removed with 10% NaOH followed by repeated washes (as above). To prevent absorption of atmospheric CO2, all samples were placed again in 10% HCl and then washed in deionized water until neutral. To remove chemicals used in the germination process, a 7-mm-long shell fragment from the germinated date seed weighing 80 mg was cut into six cubes of 8 mm3 and subjected to an additional series of four boil washes. All samples were heated in an evacuated sealed quartz tube with CuO as an oxygen source. The resulting CO2 was mixed with hydrogen in the ratio 2.5:1 and catalytically reduced over cobalt powder at 550C to elemental carbon (graphite). This mixture was pressed into a target and the 14C:12C ratio (for radiocarbon age) measured by accelerator mass spectrometry at the Institute for Particle Physics of the Swiss Federal Institute of Technology Zurich (ETHZ).

2) Calendar age: Calendar age was obtained using the OxCal 4.3 calibration program based on the latest IntCal 13 calibration curve (35). Calibrated calendar ages can be found with a probability of 68.3% in the 1-range and with a probability of 95.4% in the 2-range (table S2). The probability distribution P of individual ages is given for each sigma range. The 14C activity is reported as pMC (percentage of modern carbon) and corresponds to the ratio of the activity of the sample to the corrected activity of the oxalic acid standard, which has an age of 0 yr B.P.

3) Calculation of correction for pMC: The effect of contamination by modern carbon incorporated during seedling growth previously shown in our first germination of an ancient date seed to reduce measured age by 250 to 300 years (equivalent to 2 to 3% pMC) (6) was calculated using the following three groups based on the source of the ancient seeds in both the current and previous studies:

(i) Masada: Adam (current study), Methuselah (seed 3), and seed 1 [both from previous study (6) in which seed 1 was used as a control].

(ii) Qumran Cave 13: Judith and an ancient palm frond (used as a control)

(iii) Qumran Cave 37: Boaz, Jonah, Uriel, and seed HU37A11 (used as a control)

The germinated ancient seed Hannah from Wadi Makhukh was not assigned to a group due to the absence of a suitable control and considerable disruption to the site.

Using as age-controls the ancient palm frond (Qumran Cave 13), seed HU37A11 (Qumran Cave 37) from the current study and seed 1 (Masada) from the previous study (6), we assumed that a positive pMC difference between the germinated seeds and control sample could be attributed to modern carbon that was absorbed during germination. Ages of the germinated seeds were therefore recalculated (assuming that the measurement error remains unchanged) by adjusting the measured age to the control sample. For Hannah since no control exists, an average deviation (derived from the other samples) was taken into account.

Comparison of ancient date seeds that failed to germinate with modern date seeds. This was performed on the following groups:

1) Modern date seed (P. dactylifera) samples (n = 56): Being either from cultivated varieties (n = 47) or uncultivated and possibly wild individuals (n = 9) (9). Seeds from these sources (total n = 1108) were used as a current referential for seed morphometric analysis. The cultivated modern samples originated from 11 countries spanning date palm distribution from Spain to North Africa to the Middle-East. The candidate wild date palms originated from Oman and have been hypothesized as wild date palms based on seed shape, seed size (18), and genetic studies based on microsatellite and whole-genome resequencing data (9).

2) Ancient date seeds (n = 18): Of 26 ancient date seeds obtained from Qumran, Wadi Makukh, and Wadi Kelt archaeological sites (described above) that had been planted in the quarantine site, 21 failed to germinate and were retrieved from the potting soil. Of these, three were discarded as they had fragmented and were in poor condition. The remaining 18 retrieved ancient date seeds together with modern reference seeds (described above) were rephotographed on dorsal and lateral sides, and measurements of length and width were remade (table S3) [Neither current or previous (6) ancient date seeds from Masada that failed to germinate were used in the morphometric study as these seeds were not retrieved from the potting soil].

The following statistical analyses were performed using R software (36).

1) Size analysis of modern seeds: The length and width of a total of 1108 seeds obtained from 47 current cultivated varieties (928 seeds) and 9 current wild individuals (180 seeds) were measured using ImageJ (37) following the protocol previously established by Gros-Balthazard et al. (18). The thickness was not measured since it is highly correlated with width (18).

2) Comparison of seed size between current and ancient samples: Measurements for current varieties were compared with those measured for the ancient date seeds using boxplots and Students and Tukeys tests (table S4).

3) Analysis of seed shape diversity in current and ancient date seeds: PCA (dudi.pca function) was performed on seed outlines assessed by Fourier coefficients, a morphometric method applied to outline analysis.

DNA preparation. DNA of six ancient date seedlings from the current study and one (Methuselah) from the previous study (6) was analyzed. A set of 19 SSR was used for genotyping as described by Zehdi-Azouzi et al. (4). Gender was determined using date palm sex-linked microsatellite markers (11). Maternal lineages were traced back using the plastid intergenic spacer psbZ-trnf minisatellite (12, 38). Paternal lineages were studied through Y haplotypes using the three sex-linked SSRs (mPdIRDP80, mPdIRDP50, and mPdIRDP52) (11).

Total cellular DNA was extracted from lyophilized leaves using the TissueLyser and the DNeasy Plant Mini Kit (QIAGEN SA, Courtaboeuf, France) according to the manufacturers instructions. After purification, DNA concentrations were determined using a GeneQuant spectrometer (Amersham Pharmacia Biotech, France). The quality was checked by agarose minigel electrophoresis. The resulting DNA solutions were stored at 20C.

Amplification and genotyping. Polymerase chain reactions were performed in an Eppendorf (AG, Hamburg, Germany) thermocycler. Reaction was performed in 20 l and contained 10 ng of genomic DNA, 10 reaction buffer, 2 mM MgCl2, 200 M deoxynucleotide triphosphates, 0.5 U polymerase, and 0.4 pmol of the forward primer labeled with a 5M13 tail, 2 pmol of the reverse primer, and 2 pmol of the fluorochrome-marked M13 tail and MilliQ water. A touchdown polymerase chain reaction (PCR) was carried out with following parameters: denaturation for 2 min at 94C, followed by six cycles of 94C for 45 s, 60C for 1 min, and 72C for 1 min; then 30 cycles of 94C for 45 s, 55C for 1 min, and 72C for 1.5 min; then 10 cycles of 94C for 45 min, 53C for 1 min, 72C for 1.5 min; and a final elongation step at 72C for 10 min. PCR products were analyzed using an ABI 3130XL Genetic Analyzer (Applied Biosystems, Foster City, CA, USA). Allele size scoring was performed with GeneMapper software v3.7 (Applied Biosystems).

Genetic analyses. The ancient genotypes were compared to a reference matrix (90 genotypes) containing genotyping data on current date palm varieties covering the two genetic pools defined by Zehdi-Azouzi et al. (4) and including 35 samples from the eastern pool and 55 samples from the western pool (table S5). The number of alleles per group (NA), the number of alleles with a frequency higher than 5% (NA,P), and the observed (Ho), the expected (He) heterozygosities, and the fixation index values (FIS) were estimated using the GenAlEx 6.5 program (table S6). The allelic richness of each group was also calculated via the divBasic function implemented in the R package diversity (table S6) (39).

The hierarchical classifications were generated using PHYLIP package by calculating Cavalli-Sforza and Edwards distances (40) between ancient genotypes and current varieties (table S7). The obtained distance was used to construct the dendrogram using the neighbor-joining algorithm (41). The tree was drawn using DARwin software (42).

The membership probabilities of the ancient genotypes were identified by using a model-based clustering algorithm implemented in the computer program STRUCTURE v.2.3.4 (43). This algorithm identifies clusters (K) with different allele frequencies and assigns portions of individual genotypes to these clusters. It assumes the Hardy-Weinberg equilibrium and linkage equilibrium within clusters. The STRUCTURE algorithm was run without previous information on the geographic origin of the accessions using a model with admixture and correlated allele frequencies with 10 independent replicate runs for each K value (K value ranging from 1 to 6). For each run, we used a burn period of 10,000 iterations followed by 1 million iterations. The optimal number of clusters was assigned by using the run with the maximum likelihood validated with an ad hoc quantity based on the second-order rate of change in the log probability of data between different K values (fig. S3).The optimal alignment of the independent iterations was obtained by CLUMPP v.1.1 implemented in the Pophelper software v.1.0.10 (44); Pophelper v.1.0.10 (44) was also used to plot the results for the optimal K.

Acknowledgments: We thank J. Patrich and the late E. Netzer for making available ancient date seeds from Judean desert excavations; R. Krueger (USDA-ARS, USA) for providing some current date palm varieties; and S. Zehdi (Faculty of Sciences, University of Tunis El Manar, Tunisia), A. Lemansour (UAEU, DPDRUD, United Arab Emirates), M. A. Elhoumaizi (Sciences Faculty, Morocco), and C. Newton for allowing the use of genotyping data on current date palm varieties in the reference matrix. M. Collin is acknowledged for the help in the figure preparation and T. Bdolah Abraham for the help in statistics. O. Fragman-Sapir is acknowledged for identification of ancient date seeds and C. Yeres and A. Rifkin for information on Midrashic and Talmudic Jewish source material. Funding: The study was supported by donations to NMRC from The Charles Wolfson Charitable Trust (UK), G. Gartner and the Louise Gartner Philanthropic Fund (USA), and the Morris Family Foundation (UK). Author contributions: S.S. initiated, designed, and coordinated the study, procured ancient date samples, researched historical and archaeological information and integrated it with scientific findings, and wrote the paper. E.C. and N.C. performed genetic analyses on germinated seedlings. E.S. germinated ancient date seeds. M.E. performed radiocarbon analysis. M.G.-B., S.I., and J.-F.T. performed morphometric analysis. F.A. supervised genetic analyses and with E.C., M.G.-B., and M.E. helped write the manuscript. Competing interests: The authors declare that they have no competing interests. Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. Additional data related to this paper may be requested from the authors.

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Origins and insights into the historic Judean date palm based on genetic analysis of germinated ancient seeds and morphometric studies - Science...

100-year-old Tuskegee Airman Charles McGee honored at the State of the Union – TODAY

A 100-year-old American hero stopped the political bickering in Washington, if for a brief moment.

Retired Brigadier General Charles McGee a Tuskegee Airman and a veteran of World War II, the Korean War and the Vietnam War saluted and waved to loud applause when he was introduced at Tuesday nights State of the Union address.

He was accompanied by Iain Lanphier, his 13-year-old great-grandson, who hopes to attend the Air Force Academy and join the Space Force. Both were among the special guests sitting in the balcony of the House Chamber during President Trumps speech.

McGee turned 100 last December, celebrating the milestone birthday by flying a private jet from Frederick, Maryland, to Dover Air Force Base in Delaware.

"I just fell in love with flying from the first step. I had never aspired to be a pilot," McGee told the Associated Press last fall. "But after my first flight, I was hooked."

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Hes one of the last surviving Tuskegee Airmen, an all African-American pursuit squadron that was formed in Tuskegee, Alabama, in 1941. The program included pilots, navigators, bombardiers, maintenance and support staff and instructors.

Born in Cleveland, Ohio, in 1919, McGee enlisted in the Army Air Forces in 1942 and was one of the first pilots to graduate from the Tuskegee Institute the following year, according to the National WWII Museum. He flew a total of 409 aerial fighter combat missions during 30 years of military service, more than any other Air Force pilot, according to the White House.

He received an honorary promotion to brigadier general a few weeks ago.

McGee said the reasons for his incredible longevity are simple.

"Thinking positive and the good Lords many blessings, he told WTOP in December. We human beings are just one small aspect in a mighty grand world.

It's been a busy few weeks for the centenarian: Last Sunday, McGee participated in the coin toss for the Super Bowl, one of four 100-year-old World War II Veterans to do so.

He's also taking part in Black History Month events, speaking at the Smithsonian's National Air and Space Museum this Saturday.

In a recent interview with the museum, McGee shared his favorite advice for young people, which he called the four Ps."

Perceive: Dream your dreams," he said. "I always like to add that, hopefully, among your talents, you find something you like to do. I did in aviation.

Prepare: Getting a good education is key. Learn to read, write and speak well, he said. Develop your talents.

Perform: Let excellence be your goal in everything that you do, he said.

Persevere: Thinking back to his experience as a member of the Tuskegee Airmen, McGee said, Had we not persevered, we could have gone, Oh, they called me names, they dont like me and done nothing for our country. Dont let the circumstances like that be an excuse for not achieving.

A. Pawlowski is a TODAY contributing editor focusing on health news and features. Previously, she was a writer, producer and editor at CNN.

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Human Longevity Announces the Acquisition of DoctorsForMe – Yahoo Finance

Clients now have access to Massachusetts General Hospital physician network through DoctorsForMe to help treat disease and support long-term health

Human Longevity, Inc., an innovator in providing data-driven health intelligence and precision health to physicians and patients, announced today the acquisition of DoctorsForMe, Inc. The acquisition now allows clients of Human Longevity to access world-class physicians and services of Mass General, well trusted by patients worldwide as one of the best hospitals in the world.

David Karow, MD, PhD, President and Chief Innovation Officer of Human Longevity, commented, "DoctorsForMe uses Big Data and AI technologies to match a patient with a doctor that perfectly matches the patients specific need. The acquisition enables Human Longevity to provide a complete health intelligence solution for our clients from early disease detection to personalized treatment, all with the goal of living a longer, healthier life."

ABOUT HUMAN LONGEVITY

Human Longevity provides unparalleled, precision health analytics to individuals through the Health Nucleus in La Jolla, CA. The Health Nucleus provides an assessment of current and future risk for cardiac, oncologic, metabolic and cognitive diseases and conditions. This is provided via a multi-modal approach, integrating data from an individuals whole genome, brain and body imaging via MRI, cardiac CT calcium scan, metabolic tests and more, using machine learning and artificial intelligence.

View source version on businesswire.com: https://www.businesswire.com/news/home/20200115005207/en/

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Debbie Feinberg, VP of MarketingHuman Longevity, Inc.858-864-1058dfeinberg@humanlongevity.com

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Human Longevity Announces the Acquisition of DoctorsForMe - Yahoo Finance

The Best Board Games of the Ancient World – Smithsonian.com

SMITHSONIANMAG.COM | Feb. 6, 2020, 7 a.m.

Long before Settlers of Catan, Scrabble and Risk won legions of fans, actual Roman legions passed the time by playing Ludus Latrunculorum, a strategic showdown whose Latin name translates loosely to Game of Mercenaries. In northwest Europe, meanwhile, the Viking game Hnefatafl popped up in such far-flung locales as Scotland, Norway and Iceland. Farther south, the ancient Egyptian games of Senet and Mehen dominated. To the east in India, Chaturanga emerged as a precursor to modern chess. And 5,000 years ago, in what is now southeast Turkey, a group of Bronze Age humans created an elaborate set of sculpted stones hailed as the worlds oldest gaming pieces upon their discovery in 2013. From Go to backgammon, Nine Mens Morris and mancala, these were the cutthroat, quirky and surprisingly spiritual board games of the ancient world.

Beloved by such luminaries as the boy pharaoh Tutankhamun and Queen Nefertari, wife of Ramesses II, Senet is one of the earliest known board games. Archaeological and artistic evidence suggest it was played as early as 3100 B.C., when Egypts First Dynasty was just beginning to fade from power.

According to the Metropolitan Museum of Art, upper-class members of Egyptian society played Senet using ornate game boards, examples of which still survive today. Those with fewer resources at their disposal made do with grids scratched on stone surfaces, tables or the floor.

Senet boards were long and lithe, consisting of 30 squares laid out in three parallel rows of ten. Two players received equal numbers of gaming tokens, usually between five to seven, and raced to send all of their pieces to the end of the board. Rather than rolling dice to determine the number of squares moved, participants threw casting sticks or bones. As in most complex strategy games, players had the opportunity to thwart their opponent, blocking the competition from moving forward or even sending them backward on the board.

Originally a pastime with no religious significance, writes Egyptologist Peter A. Piccione in the journal Archaeology, Senet evolved into a simulation of the netherworld, with its squares depicting major divinities and events in the afterlife.

Earlier game boards boast completely blank playing squares, but in most later versions, the final five squares feature hieroglyphics denoting special playing circumstances. Pieces that landed in square 27s waters of chaos, for example, were sent all the way back to square 15or removed from the board entirely.

The ancient Egyptians believed ritualistic gaming sessions provided a glimpse into the afterlife, according to Tristan Donovans Its All a Game: The History of Board Games From Monopoly to Settlers of Catan. Players believed that Senet revealed what obstacles lay ahead, warned dissolute souls of their fiery fates, and offered reassurance of the deceaseds eventual escape from the underworld, as represented by successfully moving ones pieces off the board.

The final space represented Re-Horakhty, the god of the rising sun, explains Donovan, and signified the moment when worthy souls would join [the sun god] Ra for eternity.

Researchers often struggle to determine the rules of games played millennia ago.

But thanks to an unassuming cuneiform tablet translated by British Museum curator Irving Finkel during the 1980s, experts have a detailed set of instructions for the Royal Game of Ur, or Twenty Squares.

The roughly 4,500-year-old games modern rediscovery dates to Sir Leonard Woolleys excavation of the ancient Mesopotamian city of Urs Royal Cemetery between 1922 and 1934. Woolley unearthed five boards, the most impressive of which featured shell plaque squares encircled by strips of lapis lazuli and decorated with intricate floral and geometric designs.

This game board, now housed at the British Museum, is structured similarly to Senet boards, with three rows of squares placed in parallel rows. The Royal Game of Ur, however, uses 20 squares rather than 30. Its shape, consisting of a 4- by 3-panel block connected to a 2- by 3-panel block by a bridge of two squares, is reminiscent of an unevenly loaded dumbbell, according to Its All a Game.

To win, players raced their opponent to the opposite end of the board, moving pieces according to knucklebone dice rolls. Per the Met, squares inlaid with floral rosettes were lucky fields, preventing pieces from being captured or giving players an extra turn.

Though the Royal Game of Ur derives its name from the Mesopotamian metropolis where it was first unearthed, Finkel notes that archaeologists have since found more than 100 examples of the game across Iraq, Iran, Israel, Syria, Jordan, Egypt, Turkey, Cyprus and Crete. Later versions of the board have a slightly different layout, swapping the right block and bridge for a single line of eight squares. (This format, better known by the name Twenty Squares, was popular in ancient Egypt, where Senet boxes often had 20-square boards on the reverse side.)

In his encyclopedic Oxford History of Board Games, David Parlett describes Mehen, which derives its name from a serpentine deity, as the Egyptian snake game. Played between roughly 3100 B.C. and 2300 B.C., the multiplayer matchup involved up to six participants tasked with guiding lion- and sphere-shaped pieces across a spiral racetrack reminiscent of a coiled snake.

The rules of Mehen remain unclear, as the game faded from popularity following the decline of Egypts Old Kingdom and is sparsely represented in the archaeological record.

Writing in 1990, Egyptologist Peter A. Piccione explained, Based upon what we know of this game ... the feline game pieces moved in a spiral along the squares, apparently, from the tail on the outside to the head of the serpent at the center. The spherical, marble-like tokens may have been similarly rolled through the longer spiralling grooves.

Surprisingly, notes Parlett, none of the probable Mehen pieces known to survive today are small enough to fit into the individual segments of the boards with which they were found, adding yet another layer of intrigue to an already mysterious game.

In fall 2018, excavations at the Russian fortress of Vyborg Castle revealed a long-forgotten medieval game board etched into the surface of a clay brick. While the find itself dates to the comparatively recent 16th century, the game it represents was first played as early as 1400 B.C., when Egyptian workmen building the temple of Kurna inscribed a Morris board onto a roofing slab.

Comparable to modern-day checkers, Nine Mens Morris found opponents directing their army of nine men, each represented by a different game piece, across a grid-like playing field. Erecting a mill, or row of three men, enabled a player to capture one of their opponents pieces. The first person unable to form a mill, or the first to lose all but two men, forfeited the match. Alternate versions of the game called for each player to rely on an arsenal of 3, 6 or 12 pieces.

Examples of Nine Mens Morris abound, unearthed in Greece, Norway, Ireland, France, Germany, England and other countries across the globe, according to Games of the World: How to Make Them, How to Play Them, How They Came to Be. The game was especially popular in medieval Europe and even earned a mention in Shakespeares A Midsummer Nights Dream.

One of ancient Scandinavias most popular pastimes was a family of strategy games known collectively as Tafl. Norsemen played Tafl as early as 400 A.D., according to the Oxford History of Board Games. A hybrid of war and chase games, Tafl spread from Scandinavia to Iceland, Britain and Ireland, but fell out of favor as chess gained traction in England and Nordic countries during the 11th and 12th centuries.

A disk-shaped gaming board unearthed in 2018 at the site of the Scottish Monastery of Deer testifies to Tafls widespread appeal. Dated to the seventh or eighth century, the board is a very rare object, according to archaeologist Ali Cameron.

Speaking with the Scotsman, Cameron added, Only a few have been found in Scotland, mainly on monastic or at least religious sites. These gaming boards are not something everyone would have had access to.

The most popular Tafl variation, Hnefatafl, deviated from standard two-player games in its use of highly unequal sides. To play, a king and his defenders battled a group of taflmen, or attackers, that outnumbered them by roughly two-to-one. As the kings men attempted to herd him to safety in one of the four burgs, or refuges, located in the corners of the grid-like game board, taflmen worked to thwart the escape. To end the game, the king had to either reach sanctuary or yield to captivity.

The toast of the Roman Empire, Ludus Latrunculorum or Latrunculi was a two-player strategy game designed to test participants military prowess. Played on grids of varying sizesthe largest known example measures 17-by-18 squaresthe so-called Game of Mercenaries was likely a variant of the ancient Greek game Petteia. (Aristotle sheds some light on Petteias rules, likening a man without a city-state to an isolated piece in Petteia left vulnerable to capture by an opponent.)

The first documented mention of Ludus Latrunculorum dates to the first century B.C., when Roman writer Varro described its colored glass or precious stone playing pieces. Two hundred or so years later, the anonymously authored Laus Pisonis painted a vivid picture of gameplay, explaining, [T]he enemy ranks are split, and you victoriously emerge with ranks unbroken, or with the loss of one or two men, and both your hands rattle with the horde of captives. The poets Ovid and Martial also referenced the game in their works.

Despite its recurrence in both written and archaeological evidence, Ludus Latrunculorums exact rules remain unclear. Various scholars have proposed potential reconstructions of the game over the past 130 years, according to Ancient Games. Perhaps the most comprehensive of these is Ulrich Schdlers 1994 essay, translated into English in 2001, which suggests players moved pieces forward, backward and sideways in hopes of surrounding an isolated enemy piece with two of their own. Captured tokens were then removed from the board, leaving victorious players hands rattl[ing] with the crowd of pieces, as Laus Pisonis put it.

In Patolli, a gambling game invented by the early inhabitants of Mesoamerica, players raced to move pebbles from one end of a cross-shaped track to the other. Drilled beans used as dice dictated gameplay, but the exact rules of entry and movement remain unknown, as Parlett notes in the Oxford History of Board Games.

Among the Aztecs, Patolli held unusually high stakes, with participants wagering not just physical goods or currency, but their own lives. As Diego Durn, a Dominican friar who authored a 16th-century tome on Aztec history and culture, explained, At this and other games the Indians not only would gamble themselves into slavery, but even came to be legally put to death as human sacrifices.

Commoners and aristocrats alike played Patolli, which was particularly popular in the Aztec capital of Tenochtitlan. According to fellow 16th-century chronicler Francisco Lpez de Gmara, even Emperor Montezuma enjoyed the game and would sometimes look on as they played at patoliztli, which much resembles the game of tables, and is played with beans marked like one-faced die which they call patolli.

Like many aspects of Aztec culture, Patolli was banned by the Spanish conquistadors who defeated the Mexican empire in the 1520s and 30s. Parlett writes that the Spaniards destroyed every gaming mat and burned every drilled bean they could find, making it difficult for later historians to piece together the games exact rules.

Modern-day chess traces its origins to the ancient Indian game of Chaturanga, whose Sanskrit name refers to the four limbs of the Gupta Empires army: infantry, cavalry, chariots and war elephants. First recorded around the sixth century A.D., but presumably played prior to this period, Chaturanga pitted four players, each assuming the role of an imperial military arm, against each other. Pieces moved in patterns similar to those seen in modern chess, according to Donovans Its All a Game. Infantry, for instance, marched forward and captured diagonally like pawns, while cavalry traveled in L-shapes like knights. Unlike todays game, however, Chaturanga involved an element of chance, with players casting sticks to determine pieces movement.

During the mid-sixth century, Indian merchants introduced a revised two-player version of Chaturanga to Persias Sasanian Empire, where it was quickly transformed into the improved game of Shatranj. (Declaring check and checkmate stems from the Persian practice of saying shah mat when an opponents shah, or king, was cornered.) When Arabic armies conquered the Sasanian Empire in the mid-seventh century, the game further evolved, its pieces assuming an abstract shape in compliance with Islams ban on figurative images.

Chess arrived in Europe by way of Arabic-held territories in Spain and the Iberian Peninsula. A Swiss monastery manuscript dated to the 990s contains the earliest known literary reference to the game, which rapidly gained popularity across the continent. By the end of the 12th century, chess was a staple everywhere from France to Germany, Scandinavia and Scotland, all of which followed a slightly different set of rules.

Per Donovan, the most radical change of all was the emergence of the queen as chess most powerful player during the 15th and 16th centuries. The shift was far from random. Instead, it reflected the previously unheard of rise of empowered female monarchs. Isabella I of Castile led her armies against the Moorish occupiers of Granada, while her granddaughter, Mary I, became the first woman to rule England in her own right. Other prominent female royals of the period included Catherine de Medici, Elizabeth I, Marguerite of Navarre and Marie de Guise.

Like many entries on this list, the exact origins of backgammon, a two-player game in which rivals race to bear off, or remove, all 15 of their pieces from the board, remain unclear. But elements of the beloved game are evident in such diverse offerings as the Royal Game of Ur, Senet, Parcheesi, Tabula, Nard and Shwan-liu, suggesting its basic premise found favor across both cultures and centuries. As Oswald Jacoby and John R. Crawford write in The Backgammon Book, the earliest conceivable ancestor of what is now called backgammon is the aforementioned Royal Game of Ur, which emerged in Mesopotamia around 4,500 years ago.

Modern backgammons most memorable characteristic is its board, which features 24 narrow triangles divided into two sets of 12. Players roll pairs of dice to determine movement across these geometric arenas, making backgammon victories a near-even mix of skill and luck, according to Donovan.

Rolls of the dice are crucial but so is how you use those rolls, he explains. This balance has made backgammon popular with gamblers since time immemoriala tendency exemplified by a Pompeiian wall painting featuring an innkeeper throwing two brawling backgammon competitors out of his establishment.

Variations of the game eventually spread to Asia, the Mediterranean, the Middle East and Europe. During the medieval period, as many as 25 versions of backgammon, including Frances Tric-Trac, Swedens Brde and Britains somewhat confusingly titled Irish, popped up across the continent. By the 1640s, the last of these had evolved into the modern game of backgammon, so named in a nod to the words back and game.

Go, then called Weiqi, arose in China around 3,000 years ago. A game of territorial occupation, according to the Oxford History of Board Games, Go is far more complex than it seems on the surface. Players take turns placing stones on a grid of 19-by-19 squares with the dual goals of capturing enemy tokens and controlling the largest amount of territory.

Although simple in its rules, writes Donovan, the size of the board coupled with the intricacies of capturing and recapturing territory and stones create a game of great complexity, closer in spirit to an entire military campaign filled with local battles rather than the single battle represented in chess.

Popular lore suggests Weiqi was first used as a fortune-telling device, or perhaps invented by the legendary Emperor Yao in hopes of reforming his wayward son. Whatever its true origins, Weiqi had become a staple of Chinese culture by the sixth century B.C., when Confucius mentioned it in his Analects. Later, the game was included as one of the four arts Chinese scholar-gentlemen were required to master. (In addition to Weiqi, aspiring academics had to learn Chinese calligraphy and painting, as well as how to play a seven-stringed instrument called the guqin.)

China may be the birthplace of Go, but Japan deserves much of the credit for developing the game that Parlett describes as involving a higher degree of sophistication than any of the worlds great board games, with the possible exception of chess. Go reached Chinas eastern neighbor around 500 A.D. and was initially played by the seemingly discordant groups of aristocrats and Buddhist monks.

By the 11th century, however, nobles and commoners alike had embraced what they called I-go, paving the way for the games ascendance in Japanese culture. During the 17th century, the ruling Tokugawa shogunate even established four schools dedicated to the study of Go.

Thus arose the system of hereditary professionals, including both masters and disciples, which raised Go to unparalleled heights of skill and cultivation, Parlett writes.

Japans elaborate Go training system fell apart when the Tokugawa shogunate collapsed in 1868, and the game lost popularity in the ensuing decades. But by the early 1900s, Go was back in full swing, and over the course of the 20th century, it gained a small but not insignificant following in the Western world.

Mancala, from the Arabic word naqala, meaning to move, is not one game, but hundreds united by several shared characteristics: namely, moving beans, seeds or similarly shaped tokens across a board filled with shallow pits or holes. The family of games emerged between roughly 3000 and 1000 B.C., with examples of mancala-like rows of holes appearing at archaeological sites across Africa, the Middle East and southern Asia.

The most popular mancala variant, Oware, finds two participants playing on a board with two rows of six holes. Players take turns sowing seeds by picking up tokens in a given pit and depositing them, one-by-one, in sequence around the board. Fast gameplay is encouraged, as taking ones time is considered anathema to the spirit of the game.

Mancalas goal is usually to capture more seeds than ones rival by counting and calculating strategic moves. But in some cultures, ensuring the games longevity is actually more important than winning. Though nothing is left to chance in most variations, mancala is often viewed as a gambling or ritualistic game, with its outcome considered at least partly fate-determined, according to Parlett.

[It] is a game of perfect information, perfect equality, much freedom of significant choice, and hence great skill, he writes. The complexity of chess lies in its depth, that of mancala in its length.

Though not technically an ancient creation, the Game of the Goose warrants inclusion on this list as the earliest commercially produced board game. A race governed purely by chance, the competition involves not the slightest element of skill or true player interaction towards the winning of stakes, according to Parlett.

The earliest reference to the Game of the Goose dates to between 1574 and 1587, when Duke Francesco de Medici gifted a game called Gioco dellOca to Spains Philip II. Per the Victoria & Albert Museum of Childhood, the pastime quickly spread across Europe. As soon as June 1597, one John Wolfe described it as the newe and most pleasant game of the Goose. Over the following centuries, various versions emerged, each with its own distinct illustrations and theming.

Though the Game of the Gooses visual elements varied widely, the basic premise remained the same. Players vied to send their pieces to the center of a coiled, snake-like board, traveling counter-clockwise as guided by dice rolls. Six of the boards 63 numbered spaces were illustrated with symbols denoting special rules, such as skip ahead to space 12 after landing on space 6, The Bridge, or start over entirely upon arriving at space 58, the ominously named Death tile. As suggested by the games name, images of geese feature heavily on most game boards.

To winor claim a pot established at the start of the racea player has to land on space 63 with an exact dice throw. Those who roll higher numbers than needed are forced to retreat back down the track.

In many ways, argues Parlett, the Game of the Goose may be said to usher in that modern period of board-gaming characterized by the introduction of illustrative and thematic elements to what had hitherto been primarily symbolic and mathematical.

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The Best Board Games of the Ancient World - Smithsonian.com

What the discovery of a new HIV strain means for the pandemic – The Conversation Africa

The discovery of a rare new strain of HIV for the first time in nearly 20 years recently made headlines around the world.

The big question is what the discovery means for the overall response to the HIV epidemic.

A team of US researchers from Abbott, an American medical devices and health care company, led by Mary Rodgers and co-authors at the University of Missouri, announced the discovery in a study published in the Journal of Acquired Immune Deficiency Syndrome. The new subtype is the first strain to be identified since guidelines for classifying new HIV strains were first established in 2000.

HIV has a multitude of different subtypes and, like other viruses, it changes (mutates) over time. This new strain is an important discovery, but it does not signify a new public health threat. It occurs rarely and can be effectively treated with existing antiretrovirals. Because antiretrovirals target characteristics of HIV that are common across all different subtypes, this new finding will not affect treatment and antiretroviral agents will still be effective as long as drug resistant mutations have not occurred.

The essence of the discovery is that it enhances scientists understanding of the complexity of the human immunodeficiency virus and its evolution and adds detail to the already comprehensive viral picture.

Having a thorough understanding of HIV is crucial in ensuring that HIV tests are effectively detecting the virus. Deeper insights could also have a bearing on vaccine development.

There are two main types of HIV. HIV-1 is the most common. HIV-2 is less common and accounts for fewer infections. The strains of HIV-1 can be classified into four groups M, N, O and P. While N, O and P are quite uncommon, group M is responsible for most of the global HIV epidemic, accounting for roughly 95% of all infections worldwide. The newly discovered strain (also known as a clade) is part of group M and has been labelled as subtype L.

The prevalent strain found in South Africa is known as a subtype of clade C.

One of the candidate HIV vaccine regimens currently under investigation in South Africa is designed to be effective against subtype C. It is not yet known whether, if found to be effective in this region, it will be as effective in a region with a different prevalent strain. For example, in the US the predominant strain is subtype B.

The process of confirming a new strain of any virus can be long. Three separate cases need to be identified before a new subtype can be announced. The first two cases of this new strain were found in the Democratic Republic of Congo in 1983 and 1990 and the third case in 2001. So while the strain has been known to scientists for 18 years, the entire genome needed to be tested for confirmation. The technology to do this did not exist at the time.

The genome sequencing technology available today allows scientists and researchers to build entire genomes at a faster rate and lower cost than ever before. To use this next-generation technology successfully, the responsible scientists had to apply new techniques that focus on the virus portion of the collected sample in order to fully sequence the genome.

From a scientific point of view, the discovery helps us stay one step ahead of a virus. Furthermore, the role that new technology played in identifying the strain serves as an important reminder of how far we have come. The innovation and advancements in technology and molecular virology should be celebrated.

The fight against HIV has made some formidable gains in treatment and treatment outcomes with remarkable gains in longevity.

UNAIDS estimates that new infections have decreased by 16% from 2,1 million in 2010 to 1,7 million in 2017. Undoubtedly one of the most promising achievements is the reduction in mother-to-child transmissions around the world. But the HIV response does not favour complacency.

The notion that HIV is no longer an emergent threat is one that jeopardises the work of scientists and communities who continue to drive prevention of HIV and fight against the pervading stigma. The HIV emergency is not over. The epidemic still needs vigilant attention, especially as reduction rates stall.

The ultimate solution is a working cure and preventative vaccine. The HVTN studies in South Africa are currently conducting HIV preventative vaccine trials in the hope that one day there will be an effective vaccine to prevent HIV. But until then, we need to refocus our energy on scaling up the effective treatment and prevention tools we have in hand to all those who need them.

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What the discovery of a new HIV strain means for the pandemic - The Conversation Africa

NSF grant funds research to study nature-based solutions for river restoration – Penn State News

UNIVERSITY PARK, Pa. As communities look to restore their waterways after centuries of human alteration, many are turning to nature for inspiration.

River restoration projects utilizing nature-based solutions, like the Big Spring Creek restoration project in Cumberland County, Pennsylvania, revitalize their ecosystems by reintroducing natural materials like wood and debris into their design. These materials over time often amass into complex, porous structures that offer many ecological benefits but are not well understood, according to Xiaofeng Liu, associate professor of civil engineering and co-hire of the Institute of Computational and Data Sciences at Penn State.

Thanks to a $297,791 grant from the National Science Foundation, Liu will examine the nature-based solution of engineered log jams to quantitively describe the flow and sediment dynamics around these systems.

Xiaofeng Liu, associate professor of civil engineering

These are expensive projects, but theres not too much of a scientific understanding of what really is going on, Liu said. How does the water move around the in-stream structures? How does it carry solute and sediment?

In contrast to restoration projects that use concrete and steel, water and sediment are able to flow through the pores in the nature-mimicking structure, creating unique turbulent flow patterns.

The porosity creates more complexity and richness in the flow features, Liu said. Water can go through them and around them. This complex flow field is important for the functionality and longevity of the structure.

As these flow patterns develop, sediment is transported and sometimes filtered by the wood and debris. This sediment movement around the log jam can also result in scour holes that can become habitats and shelters for fish, a desirable characteristic of nature-based solutions. However, Liu noted, these holes develop differently than they would around traditional impervious structures, such as bridge piers, and can have an effect on the longevity of the structure.

For engineers looking to install an engineered log jam, the lack of fundamental understanding of these complex flow patterns means relying on educated guess. Formulas that currently exist to predict scour hole size and depth do not account for porosity.

Its a lot of trial and error at this stage right now, Liu said.

Based on preliminary results, Liu developed his own formula using porosity as a parameter to help predict scour hole size for nature-based solutions. He will test this by developing a high-fidelity 3D model to simulate the flow and sediment dynamics in a river containing an engineered log jam.

Mathematically resolving all of the geometric details found in an engineered log jam requires a lot of computing power, so Liu will rely on the ICS-ACI, Penn States high-performance research cloud, to run the simulations.

The mathematical equations in the model are just the descriptions of the physical processes in this problem, Liu said. Flow carries the sediment and creates a hole. When holes are enlarged, water has more space to go. Our model describes this co-evolution with the presence of a complex restoration structure.

Liu will also run physical experiments in a 15-meter flume, an artificial water channel in the Penn State Hydraulics Laboratory, using scaled-down engineered log jam models. After each experiment, he will drain the flume and use a laser to scan the bed. The results of the flume experiments will then be cross-referenced with the computational model and with field measurements to validate results.

If Liu succeeds and is able to establish a fundamental understanding of the physical processes occurring around these structures, future research will then be able to link that to ecological processes, which should give scientists a better idea of how well these solutions are achieving their sustainability goals.

Thats the final goal, Liu said. Hopefully, with the introduction of nature-based solutions, nature can start to re-establish itself. When nature is working, you dont need too much human intervention.

Last Updated January 16, 2020

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NSF grant funds research to study nature-based solutions for river restoration - Penn State News

Moderna Partners with AWS to Explore the ‘Software of Life’ – BioSpace

The software of life. Thats how Stephane Bancel, the chief executive officer of Moderna, described messenger RNA (mRNA), which is at the core of Modernas drug development process.

Moderna is pioneering mRNA drugs that are believed to be able to direct the body to produce any protein of interest, including antibodies and other proteins that can create therapeutic activity. Bancel said mRNA is an information molecule.

Its like software, he said.

The company, which has secured enormous investments over the past few years, is inching closer to being a commercial company in developing personalized therapies for a wide range of diseases, including cancer. In order to create those personalized medicines, the Cambridge, Mass.-based company relies on gene sequencing and a partnership with one of the worlds largest companies Amazon.

In an interview with CNBCs Jim Cramer during the J.P. Morgan Healthcare Conference this week, Bancel said the company relies on Amazon Web Services to compare every letter of DNA in the sequencing process. Once that is done, the company can deduce what needs to be done to develop personalized medicine, Bancel explained.

Amazon Web Services, the fastest growing division of the company, according to CNBC, provides on-demand cloud computing platforms to companies. Moderna is currently using Amazon Web Services with more than a dozen drug candidates in its pipeline, which means the high-tech platform plays a central role in the companys drug development program. As CNBC explains, the company is using the powerful cloud-based service to speed up the time it takes a drug candidate to move from the preclinical to the clinical phase. In addition to Moderna, Amazon Web Services is being used by several pharmaceutical companies, including San Diego-based Human Longevity Inc., Regeneron Pharmaceuticals and more.

The reliance on the high-speed program could lead to the company finally becoming a commercial entity 10 years after it was launched. Last week, just ahead of JPM, Bancel pointed to one of the companys clinical candidates as a potential blockbuster, an experimental treatment for cytomegalovirus (CMV), the most common infectious cause of birth defects in the United States.

Moderna said the analysis following a Phase I trial, which was taken after the third and final vaccination, shows continued boosting of neutralizing antibody titers in patients. The mRNA-based vaccine, mRNA-1647, is designed to protect against CMV infection. Cytomegalovirus is a common pathogen and is the leading infectious cause of birth defects in the United States with approximately 25,000 newborns in the U.S. infected every year. CMV is passed from the mother to her unborn child. Birth defects occur in about 20% of infected babies. The defects can include neurodevelopmental disabilities such as hearing loss, vision impairment, varying degrees of learning disability and decreased muscle strength and coordination. There is no approved vaccine to prevent CMV infection.

In October, the company received Fast Track Designation from the U.S. Food and Drug Administration for mRNA-3927, its investigational mRNA therapeutic for propionic academia, which is caused by the inability of the body to breakdown certain proteins and fats which leads to the build-up of toxic chemicals. Moderna plans to initiate an open-label, multi-center, dose-escalation Phase I/II study of multiple ascending doses of mRNA-3927 in primarily pediatric patients.

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Moderna Partners with AWS to Explore the 'Software of Life' - BioSpace

Pollution woes add to our ongoing survival struggle – Tehelka

Smog enveloping the capital city. New Delhi caught in that smog, human beings affected, breathless and restless. Choking and crying out, as smog tightens its hold on our throats and chestskilling us in that slow steady way.

Inhalers and masks the urgent need of the day, as citizens go coughing amidst cries trying to survive in this faade-ridden scenario where even encounters are turning out to be fake. Harnessing of that tiny little mosquito or any of the strays loitering around seemingly impossible by all possible might under the state machinery, so in utter frustration they hound and pound the two-legged human being ,who is anyway dying a painfully slow death in these developed times!

And as I walked around, gasping in the midst of this haze, I came across several freshly opened medical outlets equipped with surgical dens. Nah, not to be confused with surgical strikes, though not too certain of the near killing sessions well-inside in the operation theatres. Outside the hospital wards and operation theatres, the dying and even the undying discussing death and the human destruction in these developed times.

Though this smouldering smog can be called as one of those levellers but even here money coming to the rescue of those well-equipped with sagging-pockets. For them holds out an array of air purifiers and conditioners and all those get- away destinations How many amongst us can actually flee?

Wrapped in nostalgia, wondering rather aloud: werent we better off in those good old days when developing or under-developed we were with fewer wants.Just two square meals and that once in a while dining out sessions seemed to take care of everyday wants.

The skies up there looked blue .The flowers bloomed. The human face looked carefree and hassle freethe human form was still intact and those cravings for emotional anchorages were not to be confused with surcharged sexual releases. Those were the good old days when we actually lived and lived quite happily! Not like today where even the basic traces of survival are turning out to be an ongoing struggle for survival.

I am more than shocked when rulers of the day continue to talk of growth, development, longevity, and whatever else they can package in their package of lies. In fact, contrary to their claims, today, in these so called developed times we are more prone to deaths and decay.

The environmental pollution is killing our very organs. Not to overlook the noise pollution hitting the very heart. And the limbs cannot be left spared with strays around. In fact, in these recent months wherever I have travelled local residents have cried out, detailing the havoc caused by monkeys and dogs on the prowl. Blatantly attacking pedestrians and intruding into homes and fields yet there is nobody out there to harness their moves. Shouldnt the municipal authorities step in? Shield the human being from these deadly attacks. In fact, though we talk of dengue and viral fevers but little focus on rabies. Why? Whats become of us to be overlooking these deadly animal bites and attacks.Today who cares whether our flesh is ripped through and we die a painful death!

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Pollution woes add to our ongoing survival struggle - Tehelka

Gail Fisher’s ‘Dog Tracks’: Spoiling you dog with extra food could cut short its life – The Union Leader

HERE IT IS just a few days after Thanksgiving, and Im probably not alone in thinking about the poundage I usually put on (then struggle to lose) in just one extremely treat-filled month. There is no doubt from the many studies on this topic about the relationship between weight and longevity in humans. While there are no studies of longevity in dogs that Im aware of, its likely the same relationship exists.

Longevity in dogs is a problem or rather lack of longevity. The American Veterinary Medical Association claims dogs are living longer. Longer than what? A hundred years ago, sanitation and medical improvements saved infants and the young from early death, greatly affecting human longevity. The claim that dogs are living longer might be related to the reduction and elimination of diseases that kill puppies. At the other end of the spectrum, the sad fact is that dogs do not live as long as they used to.

When I was a child, dogs often lived well into their teens. My next-door-neighbors dog, an Irish setter, was the same age as I. She died when I was a freshman in college. We were both 17. They also had a cocker spaniel that lived to be 20!

Nearly 50 years ago, I interviewed for a job at a Newfoundland kennel with more than 40 dogs, many that were 18 to 20 years old. They fully expected their dogs to live well into their mid-to late teens. Now, a mere 45 years later, a Newfie that lives to be 10 is old hardly an increase in longevity.

While genetics plays a role in longevity, there is a profound message for dog owners in this simple statement: Thin creatures live longer than fat ones.

Could it be that our pets reduced longevity is in part because we feed them too much? There is a lot we dont know about why so few dogs live into their late teens, but certainly one factor could well be excess weight even just a few too many pounds. A 50-pound dog that is just 10 pounds overweight is carrying 20% more weight than its frame and organs are designed for. This is considered to be obesity in humans, but in dogs its considered show weight or proof that we love and spoil our dogs usually said with an apologetic shrug.

If by spoiling our dogs were shortening their lives, wouldnt it be better to be tough (read kind) and cut out fattening snacks? Consider the greyhound, a large, sleek hound with a life expectancy many years beyond large, heavier hounds. Bloodhounds, a similar size, but much heavier dog, live to 10 or 11, while a greyhound often lives to 14 or 15. Greyhounds are one of the only show dogs for whom show weight is not overweight. You can see the ribs of a healthy greyhound, while it is often hard to even feel the ribs on many pet dogs.

I firmly believe that one of the reasons my English mastiffs lived to 13 or 14 (years beyond the life expectancy of the breed) was in part because I keep my dogs thin anathema for many mastiff people. For many giant breed owners, bigger is better. Theyll proudly exclaim, My Mastiff weighed 250 pounds! He might have died at the age of 6 and could barely walk because he was grossly overweight, but, by golly, he was huge!

Veterinarians we talk to almost universally agree that most pet dogs are too fat. In many cases, they have given up fighting that battle. Despite recommendations that the dog needs to lose weight, many owners seem to have a hard time cutting back on their dogs food and seem to believe theyre punishing their dog if they provide low-fat snacks. Youre not! Youre being kinder to your dog.

So in this holiday season, consider not sharing your turkey skin and leftover gravy with your dog. Or if you do, cut back on your dogs food that day. Your dog wont hate you for it, and you might well have him around a few extra months or years.

Gail Fisher, author of The Thinking Dog and a dog behavior consultant, runs All Dogs Gym & Inn in Manchester. To suggest a topic for this column, which appears every other Sunday, email gail@alldogsgym.com or write c/o All Dogs Gym, 505 Sheffield Road, Manchester, NH 03103. Past columns are on her website.

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Gail Fisher's 'Dog Tracks': Spoiling you dog with extra food could cut short its life - The Union Leader

Commentary: We need a major redesign of life – Bend Bulletin

Its time to get serious about a major redesign of life. Thirty years were added to average life expectancy in the 20th century, and rather than imagine the scores of ways we could use these years to improve quality of life, we tacked them all on at the end. Only old age got longer.

As a result, most people are anxious about the prospect of living for a century. Asked about aspirations for living to 100, typical responses are I hope I dont outlive my money or I hope I dont get dementia. If we do not begin to envision what satisfying, engaged and meaningful century-long lives can look like, we will certainly fail to build worlds that can take us there.

In my view, the tension surrounding aging is due largely to the speed with which life expectancy increased. Each generation is born into a world prepared by its ancestors with knowledge, infrastructure and social norms. The human capacity to benefit from this inherited culture afforded us such extraordinary advantages that premature death was dramatically reduced in a matter of decades. Yet as longevity surged, culture didnt keep up.

Long lives are not the problem. The problem is living in cultures designed for lives half as long .

Retirements that span four decades are unattainable for most individuals and governments; education that ends in the early 20s is ill-suited for longer working lives; and social norms that dictate intergenerational responsibilities between parents and young children fail to address families that include four or five living generations.

Last year, the Stanford Center on Longevity launched an initiative called The New Map of Life. We began by convening a group of experts, including engineers, climate scientists, pediatricians, geriatricians, behavioral scientists, financial experts, biologists, educators, health-care providers, human resource consultants and philanthropists. We charged them with envisioning what vibrant century-long lives would look like and then began the remapping process. How do traditional models of education, work, lifestyles, social relationships, financial planning, health care, early childhood and intergenerational compacts need to change to support long lives?

We quickly agreed that it would be a mistake to replace the old rigid model of life education first, then family and work, and finally retirement with a new model just as rigid. Instead, there should be many different routes, interweaving leisure, work, education, family throughout life, taking people from birth to death with places to stop, rest, change courses and repeat steps along the way. Old age alone wouldnt last longer; rather, youth and middle age would expand, too.

We agreed that longevity demands rethinking of all stages of life, not just old age. To thrive in an age of rapid knowledge transfer, children not only need reading, math and computer literacy, but they also need to learn to think creatively and not hold on to facts too tightly. Theyll need to find joy in unlearning and relearning. Teens could take breaks from high school and take internships in workplaces that intrigue them. Education wouldnt end in youth but rather be ever-present and take many forms outside of classrooms, from micro-degrees to traveling the world.

Work, too, must change. Theres every reason to expect more zigzagging in and out of the labor force especially by employees who are caring for young children or elderly parents and more participation by workers over 60.

Financing longevity requires major rethinking. Rather than saving ever-larger pots of money for the end of life, we could pool risks in new ways. Generations may share wealth earlier than traditional bequests; we can start savings accounts at birth and allow young adults to work earlier so that compound interest can work in their favor.

Maintaining physical fitness from the beginning to end of life will be paramount. Getting children outside, encouraging sports, reducing the time we sit, and spending more time walking and moving will greatly improve lives.

In the year since this initial meeting, we have launched a postdoctoral program focused on deep dives into core domains of life that must change. The aim is to develop specific recommendations for governments, employers, businesses, parents and policymakers so that we can begin to lay the groundwork for cultures that support century-long lives. The challenges demand extraordinary social, scientific and educational investments. The opportunities are even more extraordinary.

Longer lives present us with an opportunity to redesign the way we live. The greatest risk of failure is setting the bar too low.

Laura Carstensen, a professor of psychology, is the director of the Stanford Center on Longevity.

Laura Carstensen, a professor of psychology, is the director of the Stanford Center on Longevity.

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Commentary: We need a major redesign of life - Bend Bulletin

How Bitcoin points to the future of decentralized protest – Decrypt

Protests throughout the world, in Hong Kong, Chile, France, the Middle East and elsewhere, are embracing the principles and products of cryptocurrencyin many cases without even knowing it.

Todays movements are made up of hundreds and thousands of protestors, groups of disparate individuals aligned around values and causes. The decentralized networks theyve adoptedreliant on technology rather than leaderscould ensure their longevity. It could also permanently alter the geopolitical landscape.

In the same way, blockchain, the technology that underpins Bitcoin and other cryptocurrencies, is reliant on decentralized networks.

But just how closely aligned are these leaderless movements with the similarly decentralized blockchain and cryptocurrencies? And what impact are they having on the adoption of decentralized principlesand, ultimately, on the price and perception of crypto?

The Internet provides a backbone for 21st century rebellion, but is also its weakest link.

The Swiss Army Knife for modern day protesters is the smartphone; a communications tool thats also a camera, GPS and more besides. The killer app is private, encrypted social media and messaging apps such as Telegram, with its secret chat function.

These tools enable protestors to evade surveillance; form anonymous groups; post video footage; agree how and where to rally, and request additional supplies.

But, earlier this month, Iranian authorities showed how they can be defused.

Mass demonstrations against petrol rises, the result of US sanctions, turned violent but were quickly diffused when Iran pulled the plug on Internet connectivity for over 90% of the country.

Its not an easy thing to do. But regimes around the world, including those in Russia, have been busy retrofitting traditional private and decentralized networks with cooperation agreements, technical implants, or a combination of both, to give themselves more power over Internet access.

In both Russia and Iran, Telegram has been banned by authorities since last year. But Russian dissidents have managed to find ways around the ban, often using VPNsVirtual Private Networkswhich route an Internet connection through a different country. Telegram founder Pavel Durov has also proved adept at moving the companys servers to stay one step ahead of authorities.

Decentralized applications, dapps, are also becoming increasingly popular. Messaging apps Bridgefy and FireChat both work by creating a mesh network of users mobile phones offline, via Bluetooth. Messages are relayed from phone to phone until they reach their destination.

But the technology is still nascent and not practical in confrontational situations, say protestors. And its especially difficult for Iranians to access foreign servers and infrastructure because many companies ban them for fear of US sanctions.

One of the main attractions (and criticisms) of Bitcoin is that it can be used indiscriminately by anyone from protestors to terrorists to sanctioned regimes. Everyone from the Iranian regime, which has mined bitcoin to dodge sanctions, to Ukrainian protestors, who held up signs with QR codes during 2014s Maidan Square uprising in a bid to raise funds, has taken advantage of its censorship resistance.

Fundraising techniques are becoming increasingly sophisticated to evade detection; the armed wing of Palestinian group Hamas reportedly uses a fresh digital wallet for each transaction. But for donations, even cryptocurrency is fallible. Payment processor BitPay was accused of blocking crypto donations to the Hong Kong Free Press for several weeks last October.

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Of course, being associated with funding for terrorist groups, and other violent organisations, doesnt do the image of cryptocurrencies any favours.

Nevertheless, Bitcoin proponents such as Morgan Creek Digital co-founder Anthony Pompliano, believe that the non-seizability of Bitcoin becomes ever more attractive in moments of geopolitical crisis.

Data for OTC (Over-the-counter) crypto trades from LocalBitcoins suggests that, during the early months of the Hong Kong protests, peer-to-peer trading increased. A further spike appears to coincide with the protests escalation, at the end of last month.

Libertarians point to events in troubled countries such as Chile, which is seeing widespread protests over long-standing economic injustice. ATMs reportedly ran out of cash there earlier this month. They argue that when people experience such measures, theyre more likely to sell local currency for bitcoin to escape the uncertainty surrounding the legacy markets. Essentially, it's a tool of freedom for people under tyranny and that's significant, Bitcoin advocate Jimmy Song told Decrypt back in September.

Song has been working with the non-profit Human Rights Foundation to teach activists how Bitcoin might be useful to them. Its a significant part of what Bitcoin is supposed to be. Its becoming a much bigger part of the human rights movement all around the world, he said.

But while enthusiasts might be quick to suggest that Bitcoin is acting as a safe haven for funds, or a protest tool in Hong Kong, analysts warn that reliance on a single source is unwise.

Hong Kong's 2014 Umbrella Movement shaped the form of today's protest. IMAGE: Flickr

LocalBitcoins volumes are one indicator but they're hardly reflective of the full BTC market in any given region, Mati Greenspan, founder of the Quantum Economics newsletter, told Decrypt.

He said that investment funds and analysts are tracking protest movements and political instability as bellwethers of crypto price, but emphasized that economic stability remains the most important factor.

In countries where the local currency sees massive devaluation the propensity to hold bitcoin is much higher, he said. Correlations between buying activity and inflation in Venezuela, or political events in Argentina are more likely, he believes.

But thats assuming funds are accessible. In Lebanon, five weeks of anti-government protests were fuelled by anger at corruption, and bank accounts were frozen. Protestors there reported that digital assets are rarely useful as currency, since citizens were cut off from global exchange platforms.

Leaderless rebellion is not new, despite recent headlines. In the 1980s, during the last phase of the anti-apartheid struggle, black Africans evaded martial law by organizing in a cell-like structure. A major factor in the movements eventual success was the effective coordination of economic boycotts against white businesses by these so-called cells.

Similarly, in the ongoing Hong Kong protests, members of the protest movement made an early decision to eschew centralized leadership. The fact that all the leaders of the unsuccessful 2014 Umbrella movement protest were convictedand received sentences ranging from two to 16 monthsis still fresh in citizens minds.

But decentralized protest is mushrooming even in areas of the world where penalties for rebellion are far less severe. The Occupy movement over wealth inequality, which started with Occupy Wall Street, went viral in 2011, after thousands of protestors pitched tents in the heart of New York City.

Most recently, Extinction Rebellion (XR), a global, non-violent protest movement sparked by the lack of government action over climate change, mobilized hundreds of thousands to take part in civil disobedience.

Decentralized organization gives you a great deal of autonomy, which I think appeals to people who become involved in protests and activism because they tend to be protesting against authority figures and rigid hierarchical structures anyway, Steve Tooze, a local organizer for XR, told Decrypt.

He believes that, like himself, many of those joining the movement have a minimal history of activism. I think people are desperatein our current climate of growing authoritarianismto feel empowered, and able to have agency of their own, and I think XR gives that to them, he said.

Tooze praised the fluid and transparent nature of the movement, which seeks to adhere to a detailed constitution, empowering anybody to act so long as they agree to its core principles, But he admitted that the process of reaching consensus on which actions to pursue could be time consuming and frustrating.

But the biggest challenge facing XR, he contends, is the authorities determined persecution of figures perceived to be XR leaders. Roger Hallam, one of the movements founders, is seen as something of a driving force behind it. Last week, he was accused of anti-Semitism for comments he made about the Holocaust, and disowned by the German faction of the group.

Earlier this year, XR members also disowned a controversial plan he was involved in, to fly drones and disrupt holiday flights at Heathrow, the UKs busiest airport. The consensus was that it crossed the line of non-violent protest.

But other controversial actions have gone ahead. During one rush-hour protest at Londons Canning Town, protestors attempting to stop trains were dragged down from their roofs by angry commuters.

Tooze said that the Canning Town action was massively controversial, but that, like other major actions, it was subject to extensive debate beforehand. He emphasized that, in 99.9% of cases, there were no problems, but explained that if a group of people decide theyre going to carry out an action, if there are three of you, and you adhere to the principles, you can act in the name of XR.

XRs decision-making structures, the connection between loose groups of rebels, and ways to make communications more effective, are all under review, said Tooze. The movement is currently processing an extensive survey among its membership, which will inform the future choices it makes.

Its very difficult for mass movements to prevent unwelcome or unhelpful actions or words by minorities among the memberswords or actions which can then be used by enemies to judge or condemn the whole movement, Carne Ross, author of The Leaderless Revolution: How Ordinary People Will Take Power and Change Politics in the 21st Century, told Decrypt.

The only recourse is to emphasize, to the press, that the minority do not represent the majority, even if its inevitable that those who use violence or provocative words will get more attention, he said.

He added that it was legitimate, in his opinion, to exclude and publicly condemn those who endanger the movement by negative actions or words. A former British diplomat turned anarchist, Ross contends that successful and long-standing examples of leaderless rebellion do exist, and can provide a template for the future.

As an example, he points to the forums that take the place of leadership in Rojava, a region in Northern Syria which revolted against the regime in 2012 and achieved de-facto autonomy as a result. He contends that, thanks to modern communications and social media, such movements can scale with unprecedented speed and range to a massive extentthats what is so exciting about them.

Technology, he said, means you dont need a leader to disseminate strategy, which can spread horizontally. And, while authorities can turn off the Internet, its not a viable long-term strategy.

By their nature, communication systems like WhatsApp are decentralized, said Ross. That characteristic of decentralization gives the network its powerboth as a tool to disseminate information and tactics widely, but also to protect users against the targeting of leaders.

He also believes that, should a revolution develop into a new and more democratic way of doing things, a new way of government, then a role for cryptocurrencies should be anticipated.

But not everyone agrees. In his book The Square and the Tower: Networks and Power, from the Freemasons to Facebook, historian Niall Ferguson, warns that a Libertarian utopiaof free, equal and interconnected netizensis a romantic ideal, not borne out by the past experience of history.

Vast, new networks have been made possible but, like the networks of the past, they are hierarchical in structure, with small numbers of super-connected hubs towering over the mass of sparsely connected nodes, writes Ferguson.

The powers that lend leaderless protest its force (such as decentralized networks on the Internet) can just as easily be co-opted by the less benign forces they seek to overthrow, he suggests.

So advocates of decentralization through blockchain should keep an eye on how decentralized protestand the authorities' response to itis evolving.

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How Bitcoin points to the future of decentralized protest - Decrypt

New Report: Genomic Biomarker Market: Reporting and Evaluation of Recent Industry Developments| Bio-Rad, Beckman Coulter, Myriad Genetics, Thermo…

LOS ANGELES, United States: QY Research has recently published a report, titled Global Genomic Biomarker Market Report, History and Forecast 2015-2026, Breakdown Data by Companies, Key Regions, Types and Application. The research report gives the potential headway openings that prevails in the global market. The report is amalgamated depending on research procured from primary and secondary information. The global Genomic Biomarker market is relied upon to develop generously and succeed in volume and value during the predicted time period. Moreover, the report gives nitty gritty data on different manufacturers, region, and products which are important to totally understanding the market.

Key Companies/Manufacturers operating in the global Genomic Biomarker market include: Bio-Rad, Beckman Coulter, Myriad Genetics, Thermo Fisher Scientific, Roche, QIAGEN, Epigenomics, Almac, Pfizer, Human Longevity, ValiRx, Personalis, Eagle Genomics, Empire Genomics, Agilent, Illumina

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Protein MarkerNucleic Acid MarkerOther

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HospitalsDiagnostic and research laboratories Global Genomic Biomarker

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Key companies operating in the global Genomic Biomarker market include Bio-Rad, Beckman Coulter, Myriad Genetics, Thermo Fisher Scientific, Roche, QIAGEN, Epigenomics, Almac, Pfizer, Human Longevity, ValiRx, Personalis, Eagle Genomics, Empire Genomics, Agilent, Illumina

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TOC

1 Market Overview of Genomic Biomarker1.1 Genomic Biomarker Market Overview1.1.1 Genomic Biomarker Product Scope1.1.2 Market Status and Outlook1.2 Global Genomic Biomarker Market Size Overview by Region 2015 VS 2020 VS 20261.3 Global Genomic Biomarker Market Size by Region (2015-2026)1.4 Global Genomic Biomarker Historic Market Size by Region (2015-2020)1.5 Global Genomic Biomarker Market Size Forecast by Region (2021-2026)1.6 Key Regions, Genomic Biomarker Market Size YoY Growth (2015-2026)1.6.1 North America Genomic Biomarker Market Size YoY Growth (2015-2026)1.6.2 Europe Genomic Biomarker Market Size YoY Growth (2015-2026)1.6.3 Asia-Pacific Genomic Biomarker Market Size YoY Growth (2015-2026)1.6.4 Latin America Genomic Biomarker Market Size YoY Growth (2015-2026)1.6.5 Middle East & Africa Genomic Biomarker Market Size YoY Growth (2015-2026) 2 Genomic Biomarker Market Overview by Type2.1 Global Genomic Biomarker Market Size by Type: 2015 VS 2020 VS 20262.2 Global Genomic Biomarker Historic Market Size by Type (2015-2020)2.3 Global Genomic Biomarker Forecasted Market Size by Type (2021-2026)2.4 Protein Marker2.5 Nucleic Acid Marker2.6 Other 3 Genomic Biomarker Market Overview by Application3.1 Global Genomic Biomarker Market Size by Application: 2015 VS 2020 VS 20263.2 Global Genomic Biomarker Historic Market Size by Application (2015-2020)3.3 Global Genomic Biomarker Forecasted Market Size by Application (2021-2026)3.4 Hospitals3.5 Diagnostic and research laboratories 4 Global Genomic Biomarker Competition Analysis by Players4.1 Global Genomic Biomarker Market Size (Million US$) by Players (2015-2020)4.2 Global Top Manufacturers by Company Type (Tier 1, Tier 2 and Tier 3) (based on the Revenue in Genomic Biomarker as of 2019)4.3 Date of Key Manufacturers Enter into Genomic Biomarker Market4.4 Global Top Players Genomic Biomarker Headquarters and Area Served4.5 Key Players Genomic Biomarker Product Solution and Service4.6 Competitive Status4.6.1 Genomic Biomarker Market Concentration Rate4.6.2 Mergers & Acquisitions, Expansion Plans 5 Company (Top Players) Profiles and Key Data5.1 Bio-Rad5.1.1 Bio-Rad Profile5.1.2 Bio-Rad Main Business5.1.3 Bio-Rad Products, Services and Solutions5.1.4 Bio-Rad Revenue (US$ Million) & (2015-2020)5.1.5 Bio-Rad Recent Developments5.2 Beckman Coulter5.2.1 Beckman Coulter Profile5.2.2 Beckman Coulter Main Business and Companys Total Revenue5.2.3 Beckman Coulter Products, Services and Solutions5.2.4 Beckman Coulter Revenue (US$ Million) (2015-2020)5.2.5 Beckman Coulter Recent Development and Reaction to Covid-195.3 Myriad Genetics5.5.1 Myriad Genetics Profile5.3.2 Myriad Genetics Main Business5.3.3 Myriad Genetics Products, Services and Solutions5.3.4 Myriad Genetics Revenue (US$ Million) & (2015-2020)5.3.5 Thermo Fisher Scientific Recent Developments5.4 Thermo Fisher Scientific5.4.1 Thermo Fisher Scientific Profile5.4.2 Thermo Fisher Scientific Main Business5.4.3 Thermo Fisher Scientific Products, Services and Solutions5.4.4 Thermo Fisher Scientific Revenue (US$ Million) & (2015-2020)5.4.5 Thermo Fisher Scientific Recent Developments5.5 Roche5.5.1 Roche Profile5.5.2 Roche Main Business5.5.3 Roche Products, Services and Solutions5.5.4 Roche Revenue (US$ Million) & (2015-2020)5.5.5 Roche Recent Developments5.6 QIAGEN5.6.1 QIAGEN Profile5.6.2 QIAGEN Main Business5.6.3 QIAGEN Products, Services and Solutions5.6.4 QIAGEN Revenue (US$ Million) & (2015-2020)5.6.5 QIAGEN Recent Developments5.7 Epigenomics5.7.1 Epigenomics Profile5.7.2 Epigenomics Main Business and Companys Total Revenue5.7.3 Epigenomics Products, Services and Solutions5.7.4 Epigenomics Revenue (US$ Million) (2015-2020)5.7.5 Epigenomics Recent Development and Reaction to Covid-195.8 Almac5.8.1 Almac Profile5.8.2 Almac Main Business5.8.3 Almac Products, Services and Solutions5.8.4 Almac Revenue (US$ Million) & (2015-2020)5.8.5 Almac Recent Developments5.9 Pfizer5.9.1 Pfizer Profile5.9.2 Pfizer Main Business5.9.3 Pfizer Products, Services and Solutions5.9.4 Pfizer Revenue (US$ Million) & (2015-2020)5.9.5 Pfizer Recent Developments5.10 Human Longevity5.10.1 Human Longevity Profile5.10.2 Human Longevity Main Business5.10.3 Human Longevity Products, Services and Solutions5.10.4 Human Longevity Revenue (US$ Million) & (2015-2020)5.10.5 Human Longevity Recent Developments5.11 ValiRx5.11.1 ValiRx Profile5.11.2 ValiRx Main Business5.11.3 ValiRx Products, Services and Solutions5.11.4 ValiRx Revenue (US$ Million) & (2015-2020)5.11.5 ValiRx Recent Developments5.12 Personalis5.12.1 Personalis Profile5.12.2 Personalis Main Business5.12.3 Personalis Products, Services and Solutions5.12.4 Personalis Revenue (US$ Million) & (2015-2020)5.12.5 Personalis Recent Developments5.13 Eagle Genomics5.13.1 Eagle Genomics Profile5.13.2 Eagle Genomics Main Business5.13.3 Eagle Genomics Products, Services and Solutions5.13.4 Eagle Genomics Revenue (US$ Million) & (2015-2020)5.13.5 Eagle Genomics Recent Developments5.14 Empire Genomics5.14.1 Empire Genomics Profile5.14.2 Empire Genomics Main Business5.14.3 Empire Genomics Products, Services and Solutions5.14.4 Empire Genomics Revenue (US$ Million) & (2015-2020)5.14.5 Empire Genomics Recent Developments5.15 Agilent5.15.1 Agilent Profile5.15.2 Agilent Main Business5.15.3 Agilent Products, Services and Solutions5.15.4 Agilent Revenue (US$ Million) & (2015-2020)5.15.5 Agilent Recent Developments5.16 Illumina5.16.1 Illumina Profile5.16.2 Illumina Main Business and Companys Total Revenue5.16.3 Illumina Products, Services and Solutions5.16.4 Illumina Revenue (US$ Million) (2015-2020)5.16.5 Illumina Recent Development and Reaction to Covid-19 6 North America6.1 North America Genomic Biomarker Market Size by Country6.2 United States6.3 Canada 7 Europe7.1 Europe Genomic Biomarker Market Size by Country7.2 Germany7.3 France7.4 U.K.7.5 Italy7.6 Russia7.7 Nordic7.8 Rest of Europe 8 Asia-Pacific8.1 Asia-Pacific Genomic Biomarker Market Size by Region8.2 China8.3 Japan8.4 South Korea8.5 Southeast Asia8.6 India8.7 Australia8.8 Rest of Asia-Pacific 9 Latin America9.1 Latin America Genomic Biomarker Market Size by Country9.2 Mexico9.3 Brazil9.4 Rest of Latin America 10 Middle East & Africa10.1 Middle East & Africa Genomic Biomarker Market Size by Country10.2 Turkey10.3 Saudi Arabia10.4 UAE10.5 Rest of Middle East & Africa 11 Genomic Biomarker Market Dynamics11.1 Industry Trends11.2 Market Drivers11.3 Market Challenges11.4 Market Restraints 12 Research Finding /Conclusion 13 Methodology and Data Source 13.1 Methodology/Research Approach13.1.1 Research Programs/Design13.1.2 Market Size Estimation13.1.3 Market Breakdown and Data Triangulation13.2 Data Source13.2.1 Secondary Sources13.2.2 Primary Sources13.3 Disclaimer13.4 Author List

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New Report: Genomic Biomarker Market: Reporting and Evaluation of Recent Industry Developments| Bio-Rad, Beckman Coulter, Myriad Genetics, Thermo...