How to Pronounce Urokinase – Video

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How to Pronounce Urokinase
Learn how to say Urokinase correctly with EmmaSaying #39;s "how do you pronounce" free tutorials. Definition of urokinase (oxford dictionary): noun [mass noun] Biochemistry an enzyme produced in the kidneys which promotes the conversion of plasminogen to plasmin and can be used to dissolve blood clots. http://www.emmasaying.comFrom:Emma SayingViews:0 0ratingsTime:00:13More inHowto Style

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How to Pronounce Urokinase - Video

Akshara Kumar at TEDx@WilsonHighSchool – Video

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Akshara Kumar at TEDx@WilsonHighSchool
Akshara Kumar, a senior at Wilson High School, has been a dancer and performer ever since the age of four. She has been trained in ballet, tap, jazz, and Bharatanatyam, an ancient form of Indian classical dance that consists of telling stories and descriptions about Hindu mythology through movements, poses, and hand gestures. She has been learning Bharatanatyam for nine years, and loves presenting her dance and culture at various venues, including temples, school events, and community functions. Along with performing, Akshara enjoys spending time with her friends and family and is actively involved in her school and community. As the Vice-President of Wilson #39;s Key Club and a member of Student Government, she has participated in many fundraising and volunteering efforts both in and around Wilson. She also recently had the opportunity to represent Wilson at the Berks Outstanding Young Women #39;s Competition and received second runner-up and the Keystone Award. Her ultimate aspiration is to pursue her love of medicine by majoring in biochemistry in college and becoming a doctor. In thespirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance ...From:TEDxYouthViews:1 0ratingsTime:15:10More inEducation

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UCD Philosophy Professor Dermot Moran awarded Royal Irish Academy Gold Medal 2012 – Video

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UCD Philosophy Professor Dermot Moran awarded Royal Irish Academy Gold Medal 2012
The European Commissioner, Máire Geoghegan-Quinn, has presented Royal Irish Academy Gold Medals to UCD Professor of Philosophy, Dermot Moran and TCD Professor of Biochemistry, Luke O #39;Neill in recognition of their outstanding contributions to the Humanities and Life Sciences. Full Story: bit.ly "These awards are hard earned. Each one is a testament to a lifetime of passionate commitment to the highest standards in scholarship. And they are well-deserved recognition of scientific excellence," said EU Commissioner, Máire Geoghegan--Quinn. "The Academy Committees charged with the responsibility of shortlisting candidates for this year #39;s awards were faced with a demanding task. I am pleased about this because it shows that there was a rich pool of deserving candidates." Professor Dermot Moran, UCD School of Philosophy, University College Dublin, is one of Ireland #39;s most distinguished philosophers (metaphysics and logic). He first received international acclaim for his pioneering work on the ninth-century Irish philosopher John Scottus Eriugena. In recent decades he has become equally acclaimed for his ground-breaking contribution to the understanding of the phenomenological tradition and for his efforts to mediate between the competing traditions of analytic and continental philosophy. His book Introduction to Phenomenology, was awarded the Ballard Prize for Phenomenology in 2001, and has been translated into Chinese and Spanish. It broke new ground in its account of the ...From:MyUCDViews:3 1ratingsTime:02:40More inScience Technology

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UCD Philosophy Professor Dermot Moran awarded Royal Irish Academy Gold Medal 2012 - Video

Fast Facts: Get your gastrulation right – Video

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Fast Facts: Get your gastrulation right
Get your gastrulation right Studying biochemical pathways in gastrulation All cell behaviour can be traced back to biochemical reactions within and between cells at the molecular level. With a background in biochemistry Jeroen den Hertog dives deep into the chemical reactions that lie behind the development of a body. With his group at the Hubrecht Institute he studies a particular molecular mechanism of communication: phosphorylation and dephosphorylation and the role these processes play in the most important time of our lives which is gastrulation. Produced by Fast Facts With the support of Hubrecht Institute Thanks to the coworkers at the Hubrecht Institute, the researchers at the Jeroen den Hertog Group, Jeroen Paardekooper Overman and Suma Choorapoikayil With images from: Stichting Noonan Syndroom, European Molecular Biology Laboratory (Heidelberg) Made by: Jasmijn Snoijink 2012 In cooperation with Camera editing: Wouter Boes Music: Daan van West Graphic design: SproetSFrom:FastFactsSciencetubeViews:0 0ratingsTime:04:46More inScience Technology

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Fast Facts: Get your gastrulation right - Video

UMass Dartmouth professor lands $400K for cell imaging research

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DARTMOUTH Maolin Guo, associate professor of chemistry and biochemistry at the University of Massachusetts Dartmouth, landed a $400,000 research grant from the National Science Foundation to support the development of a molecular imaging probe for cell research.

The three-year, $400,000 grant will help support Guos research efforts to develop new ways to detect iron ions in live cells at subcellular resolution.

According to an UMass Dartmouth release, the new imaging probes will help researchers to understand how iron ions affect health, which is important because we cannot live without it - literally. Iron carries oxygen throughout the body, is necessary in the creation of DNA, and iron levels are linked to hundreds of diseases including Alzheimers, Parkinsons and certain types of cancers.

We need a better understanding of the complex mechanism of how iron acts at the subcellular level to be able to successfully develop new pharmaceuticals and other treatments, said Guo in a statement.

Earlier this year, Guos laboratory became the first to see iron ions in live cells using their imaging probe. Using the National Science Foundation grant, Guo and his team will use the imaging probe to observe how iron acts in cells, opening up a new field of scientific and medical research, according to the release.

The insights gained from this study will allow us to monitor and image how iron affects living organisms, said Guo, and to develop therapies that can change irons effects on them.

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UMass Dartmouth professor lands $400K for cell imaging research

Doctor plans to tour India

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Dr. Subhash Basu, professor emeritus of chemistry and biochemistry, will embark on a speaking tour of India on Tuesday to discuss his current research on potential new anti-cancer drugs.

Basu will make his second appearance at the International Cancer Research Symposium on Dec. 19 in Calcutta when he gives a lecture titled Probable New Therapeutic Drugs for Breast and Colon Cancers.

The invitation to this symposium is very prestigious. Sixty people from all over the world are going to Calcutta, he said. I will tell them what our plan is for the delivery of these new anti-cancer drugs.

Basus lecture tour will also include an appearance at the Indian Science Congress on Jan. 4, where he will discuss the apoptotic, or cell-killing, effects of the drugs he is working with his collaborators to develop.

Our work is important, and we get an invitation every year to speak at these sorts of things, he said.

Basu said he and his research team have discovered five to six different new anti-cancer compounds that would be useful for treating colon and breast cancer patients.

These chemicals are quite toxic to biological cells and they kill cancer cells by enhancing apoptosis, or programmed cell death, in a very micro amount, he said.

Now that these cancer-killing compounds have been discovered, Basu said the main goal of his work is to determine ways to deliver the drugs into patients at the location of the cancer without harming the healthy cells around the cancerous ones.

Cancer cells normally die of necrosis they make holes in themselves, he said. When apoptosis happens, the cell gets bigger and its DNA starts degrading until the cell cannot function.

Basu said about 50,000 women die of breast cancer in the United States each year, so his research could impact thousands of lives in the future.

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Iron holds key to immunity, shows study

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Washington, Dec 4 (IANS) Researchers have figured out why iron plays a key role in metabolism and infections, pitting bugs and animals against one another, resolving a 40-year-old debate and opening way to more potent antibiotics.

The collaborative research, led by Phillip Klebba, professor and head of department of biochemistry at Kansas State University, clarifies how micro-organisms colonise animal hosts and how scientists may block them from doing so.

Klebba's team found that E. coli, one of the deadly bugs that cause hosts of gastric infections, must acquire iron from the host to establish a foothold and colonise the gut -- a concept that was often debated by scientists.

E. coli is difficult to get rid of because it has at least eight iron acquisition systems. So when one is blocked, another opens up, journal Public Library of Science ONE, reports.

The study, conducted with with Tyrrell Conway, microarray and bioinformatics researcher from University of Oklahoma, and Salete M. Newton, Kansas research professor of biochemistry, shows how iron acquisition affects the ability of bacteria to colonise animals, which is the first stage of microbial disease.

"This paper establishes that iron uptake in the host is a crucial parameter in bacterial infection of animals," said Klebba, study co-author, according to a Kansas statement.

"For years, it was theorised that iron is a focal point of bacterial pathogenesis (mechanism by which disease is caused) and infectious disease because animals constantly defend the iron in their bodies," Klebba said.

"Animal proteins bind iron and prevent micro-organisms from obtaining it. This is called nutritional immunity, and it is a strategy of the host defence system to minimise bacterial growth. But successful pathogens overcome nutritional immunity and get the iron," Klebba said.

"This is the first time our experiments unambiguously verified the indispensability of iron in infection, because here we created the correct combination of mutations to study the problem," he added.

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Iron holds key to immunity, shows study

Kettering University Hosts Commencement on Saturday, Dec. 8

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FLINT, Mich.--(BUSINESS WIRE)--

Kettering University President Robert McMahan to give the Charge to the 2012 Graduates when Kettering University hosts Commencement ceremonies for more than 260 graduates on Saturday, Dec. 8, 2012. The 11 a.m. event is open to the public in the Connie and Jim John Recreation Center in Flint.

Kettering will graduate 213 undergraduates and 54 masters candidates during graduation services. President Robert McMahan will address the gathering with a Charge to the 2012 Graduates. Dr. McMahan became the seventh President of Kettering University in August 2011. Prior to this, he was the Founding Dean of the Kimmel School (theCollege of Engineering and Technology)at Western Carolina University.

To read more on December Commencement, visit: https://www.kettering.edu/news/260-graduate-saturday

UNDERGRADUATE STUDENT SPEAKER

"The Journey Into Our Futures," the undergraduate student commencement address, will be presented by Kemoy Jorge Orlando Smith. Smith is a Chemical Engineering major with a Biochemistry minor. He is from Kingston, Jamaica.

OUTSTANDING THESIS AWARD

The Outstanding Thesis Award for Fall 2012 goes to Stacy DeCrane of Bloomington, Ill., who is graduating with a degree in Chemical Engineering and minor in Biochemistry. Her research, "A Study of Platinum and Platinum Alloy Catalyst Dissolution Trends for Polymer Electrolyte Membrane Fuel Cell Durability," was conducted at her co-op employer Argonne National Laboratory in Argonne, Ill.

PRESIDENT'S MEDAL WINNERS: 4

A Kettering University honor recognizing scholarship, professionalism on the job and community involvement.

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Kettering University Hosts Commencement on Saturday, Dec. 8

Metabolon and Syngenta Renew Research Agreement

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RESEARCH TRIANGLE PARK, N.C.--(BUSINESS WIRE)--

Metabolon, Inc., the pioneering leader in metabolomics-driven biomarker discovery and analysis, announced today that it has renewed a multi-year agreement with Syngenta, a world leading global agribusiness. Through this agreement, Metabolon will continue to provide Syngenta broad access to its biochemical profiling technology for use in agricultural applications. Financial terms of the agreement were not disclosed.

Metabolon has extensive experience in rapidly profiling the biochemistry of plants. This metabolomics-driven approach enables the identification of biomarkers useful for the development of a wide range of diagnostics and provides insight into complex biochemical processes.

We are delighted to continue our partnership with Syngenta, a leader in seed biotechnology and crop protection products, said John Ryals, Ph.D., President and Chief Executive Officer of Metabolon. This agreement signifies not only the value our biochemical analysis and expertise brings to our collaborators, but also our commitment to helping our partners in pharmaceutical, biotechnology and consumer products sectors meet their own business objectives.

Metabolon brings us key information that helps facilitate decision-making in R&D for developing new products, said Michiel van Lookeren Campagne, Head of Biotechnology at Syngenta. As Syngenta works to bring new technology to the market for our customers, these insights are increasingly important.

About Metabolon

Metabolon, Inc. has advanced the field of metabolomics by pioneering and patenting the industrys leading biochemical biomarker discovery and profiling platform. It has developed the technology to quickly identify and measure all of the biochemicals in a biological sample through its proprietary global processing method. Through the generation and interpretation of data, this method provides a precise understanding of disease etiology and drug action, and advances personalized medicine beyond what genomics and other approaches can promise. Metabolons expertise is being embraced by a wide range of pharmaceutical, biotechnology, food and agricultural companies. Metabolytics, its biomarker discovery and analysis business, has completed over 500 client studies and processed over 50,000 samples for customers in 2011 alone. Building on its expertise in biochemistry understanding, Metabolon is also developing proprietary diagnostic tests to determine and track disease progression. For more information about Metabolon, please visit http://www.metabolon.com or contact Matt Zaske at mzaske@metabolon.com or 919-595-2200.

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Metabolon and Syngenta Renew Research Agreement

Research Shows Iron’s Importance in Infection, Suggests New Therapies

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Newswise MANHATTAN, KAN. -- A Kansas State University research team has resolved a 40-year-old debate on the role of iron acquisition in bacterial invasion of animal tissues.

The collaborative research -- led by Phillip Klebba, professor and head of the department of biochemistry -- clarifies how microorganisms colonize animal hosts and how scientists may block them from doing so. The findings suggest new approaches against bacterial disease and new strategies for antibiotic development.

The study -- in collaboration with Tyrrell Conway, director of the Microarray and Bioinformatics Core Facilities at the University of Oklahoma, and Salete M. Newton, Kansas State University research professor of biochemistry -- recently appeared in PLOS ONE. It shows how iron acquisition affects the ability of bacteria to colonize animals, which is the first stage of microbial disease.

"This paper establishes that iron uptake in the host is a crucial parameter in bacterial infection of animals," said Klebba, the senior author on the publication. "The paper explains why discrepancies exist about the role of iron, and it resolves them."

Iron plays a key role in metabolism, leading bacteria and animals to battle each other to obtain it. Klebba's team found that E. coli must acquire iron from the host to establish a foothold and colonize the gut -- a concept that was often debated by scientists.

"For years it was theorized that iron is a focal point of bacterial pathogenesis and infectious disease because animals constantly defend the iron in their bodies," Klebba said. "Animal proteins bind iron and prevent microorganisms from obtaining it. This is called nutritional immunity, and it's a strategy of the host defense system to minimize bacterial growth. But successful pathogens overcome nutritional immunity and get the iron."

Little was known about what forms of iron enteric bacteria -- which are bacteria of the intestines -- use when growing in the host, but this study shows that the native Gram-negative bacterial iron uptake systems are highly effective. Scientists questioned whether prevention of iron uptake could block bacterial pathogenesis. This article leaves no doubt about the importance of iron when E. coli colonizes animals because bacteria that were systematically deprived of iron became 10,000-fold less able to grow in host tissues, Klebba said.

"This is the first time our experiments unambiguously verified the indispensability of iron in infection, because here we created the correct combination of mutations to study the problem," Klebba said.

Enteric bacteria have so many iron transport systems that it's difficult to eliminate them all. For example, E. coli has at least eight iron acquisition systems.

"These transporters are redundant because iron is essential," Klebba said. "Bacteria are resilient. If one system is blocked, then another one takes over."

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Research Shows Iron's Importance in Infection, Suggests New Therapies

Kansas State University research shows iron’s importance in infection, suggests new therapies

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Public release date: 3-Dec-2012 [ | E-mail | Share ]

Contact: Phillip Klebba peklebba@k-state.edu 785-532-6121 Kansas State University

MANHATTAN, KAN. -- A Kansas State University research team has resolved a 40-year-old debate on the role of iron acquisition in bacterial invasion of animal tissues.

The collaborative research -- led by Phillip Klebba, professor and head of the department of biochemistry -- clarifies how microorganisms colonize animal hosts and how scientists may block them from doing so. The findings suggest new approaches against bacterial disease and new strategies for antibiotic development.

The study -- in collaboration with Tyrrell Conway, director of the Microarray and Bioinformatics Core Facilities at the University of Oklahoma, and Salete M. Newton, Kansas State University research professor of biochemistry -- recently appeared in PLOS ONE. It shows how iron acquisition affects the ability of bacteria to colonize animals, which is the first stage of microbial disease.

"This paper establishes that iron uptake in the host is a crucial parameter in bacterial infection of animals," said Klebba, the senior author on the publication. "The paper explains why discrepancies exist about the role of iron, and it resolves them."

Iron plays a key role in metabolism, leading bacteria and animals to battle each other to obtain it. Klebba's team found that E. coli must acquire iron from the host to establish a foothold and colonize the gut -- a concept that was often debated by scientists.

"For years it was theorized that iron is a focal point of bacterial pathogenesis and infectious disease because animals constantly defend the iron in their bodies," Klebba said. "Animal proteins bind iron and prevent microorganisms from obtaining it. This is called nutritional immunity, and it's a strategy of the host defense system to minimize bacterial growth. But successful pathogens overcome nutritional immunity and get the iron."

Little was known about what forms of iron enteric bacteria -- which are bacteria of the intestines -- use when growing in the host, but this study shows that the native Gram-negative bacterial iron uptake systems are highly effective. Scientists questioned whether prevention of iron uptake could block bacterial pathogenesis. This article leaves no doubt about the importance of iron when E. coli colonizes animals because bacteria that were systematically deprived of iron became 10,000-fold less able to grow in host tissues, Klebba said.

"This is the first time our experiments unambiguously verified the indispensability of iron in infection, because here we created the correct combination of mutations to study the problem," Klebba said.

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Kansas State University research shows iron's importance in infection, suggests new therapies

Duke Flags Lowered Tuesday: Former Biochemistry Chair Bob Hill Dies

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Robert L. Bob Hill, Professor Emeritus and former Chairman of the Biochemistry Department at Duke University, died Thursday, November 29 at Duke University Hospital. He was 84. Dr. Hill is survived by his wife, Deborah Steege, his son Terry Hill, his daughters Amy Hill Gery (Frank), Geneva Hill (Jim), and Becky Hill Claycomb (Larry), and his five grandchildren.

Dr. Hill was one of the great protein chemists of his generation. He was instrumental in building the reputation and ranks of the Department of Biochemistry over nearly a half century career at Duke.

Bob Hill was born in Kansas City, Missouri, in 1928. He earned a bachelors degree in chemistry in 1949 and a Ph.D. in biochemistry in 1954, both from the University of Kansas. He then moved to the University of Utah for his postdoctoral fellowship with Emil L Smith. He continued his work on protein chemistry and enzymology as a faculty member at Utah for several years.

Dr. Hill joined the Duke faculty in 1961 as an associate professor. He was recruited to the Department of Biochemistry to work in the field of protein chemistry and enzymology. He established one of the most highly regarded protein chemistry labs in the world and did work on a range of proteins and glycoproteins, most notably, lactose synthase.

Dr. Hill was appointed Professor of Biochemistry in 1965 and James B. Duke Professor of Biochemistry in 1974. He served as Chairman of the Biochemistry Department at Duke from 1969 till 1993, building one of the strongest Biochemistry Departments in the world. According to colleagues, the departments environment under his leadership was exceptional, characterized by extraordinary morale and an almost family-like atmosphere. Under Dr. Hills direction, the visibility of Duke Biochemistry increased dramatically, with his own scientific achievements contributing significantly to the departments reputation.

While at Duke, Bob Hill received continuous NIH grant support for 42 years to study the structure and function of proteins and enzymes in his lab. Hill effectively trained and mentored numerous graduate students and postdoctoral fellows in his lab, many of whom have gone on to become leaders in biochemistry. He also directed Dukes MD/PhD program for many years and taught biochemistry to first-year medical students.

Bob Hill published 175 refereed papers over the course of his career. His accomplishments have been widely acknowledged by the scientific community, including election to the National Academy of Sciences, the Institute of Medicine, and the American Academy of Arts and Sciences. He received the William C. Rose Award from the American Society for Biochemistry and Molecular Biology in 1991, the North Carolina Gold Medal (for science) in 1985 and the Karl Meyer Award from the Society for Glycobiology in 2001. Hill served as President of the American Society of Biochemistry and Molecular Biology from 1976 to 1977 and had many executive leadership roles on national and international scientific societies. Hill served admirably on the editorial board of the Journal of Biological Chemistry for 47 years, one of the longest editorial services in the journals history. In recent years, he has played major roles in the popular JBC Classics series, which highlights important papers in the history of biochemistry.

Bob Hill will be missed by his colleagues both within and outside of the Department of Biochemistry at Duke, and by his many former students and postdoctoral fellows.

In lieu of flowers, memorial contributions can be made to the Robert L. Hill Biochemistry Education Fund. Please send contributions to Kristina Amidon, Major Gift Officer, Duke Medicine Development, 512 S. Mangum Street, Suite 400, Durham, NC 27701.

Arrangements for the Hill family are under the care of Hall-Wynne Funeral Services. Online condolences: http://www.hallwynne.com, select obituaries.

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Duke Flags Lowered Tuesday: Former Biochemistry Chair Bob Hill Dies