Synthetic biology: Recreating natural complex gene regulation

Feb. 3, 2013 By reproducing in the laboratory the complex interactions that cause human genes to turn on inside cells, Duke University bioengineers have created a system they believe can benefit gene therapy research and the burgeoning field of synthetic biology.

This new approach should help basic scientists as they tease out the effects of "turning on" or "turning off" many different genes, as well as clinicians seeking to develop new gene-based therapies for human disease.

"We know that human genes are not just turned on or off, but can be activated to any level over a wide range. Current engineered systems use one protein to control the levels of gene activation," said Charles Gersbach, assistant professor of biomedical engineering at Duke's Pratt School of Engineering and member of Duke's Institute for Genome Sciences and Policy. "However, we know that natural human genes are regulated by interactions between dozens of proteins that lead to diverse outcomes within a living system.

"In contrast to typical genetics studies that dissect natural gene networks in a top-down fashion, we developed a bottom-up approach, which allows us to artificially simulate these natural complex interactions between many proteins that regulate a single gene," Gersbach said. "Additionally, this approach allowed us to turn on genes inside cells to levels that were not previously possible."

The results of the Duke experiments, which were conducted by Pablo Perez-Pinera, a senior research scientist in Gersbach's laboratory, were published on-line in the journal Nature Methods. The research was supported by the National Institutes of Health, the National Science Foundation, The Hartwell Foundation, and the March of Dimes.

Human cells have about 20,000 genes which produce a multitude of proteins, many of which affect the actions of other genes. Being able to understand these interactions would greatly improve the ability of scientists in all areas of biomedical research. However because of the complexity of this natural system, synthetic biologists create simple gene networks to have precise control over each component. These scientists can use these networks for applications in biosensing, biocomputation, or regenerative medicine, or can use them as models to study the more complex natural systems.

"This new system can be a powerful new approach for probing the fundamental mechanisms of natural gene regulation that are currently poorly understood," Perez-Pinera said. "In this way, we can further the capacity of synthetic biology and biological programming in mammalian systems."

The latest discoveries were made possible by using a new technology for building synthetic proteins known as transcription activator-like effectors (TALEs), which are artificial enzymes that can be engineered to "bind" to almost any gene sequences. Since these TALEs can be easily produced, the researchers were able to make many of them to control specific genes.

"All biological systems depend on gene regulation," Gersbach said. "The challenge facing bioengineering researchers is trying to synthetically recreate processes that occur in nature."

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Synthetic biology: Recreating natural complex gene regulation

FASEB SRC announces conference registration open for: Ciliate Molecular Biology

Public release date: 4-Feb-2013 [ | E-mail | Share ]

Contact: Robin Crawford src@faseb.org 301-634-7010 Federation of American Societies for Experimental Biology

Bethesda, MD The Federation of American Societies for Experimental Biology (FASEB) announces the opening of registration for the Science Research Conference (SRC): Ciliate Molecular Biology.

The 2013 FASEB Conference on Ciliate Molecular Biology is a unique forum for researchers who study Ciliates as model organisms, to share their recent results. Current work using Ciliates is making important contributions to a large number of fields including the role of small RNAs in chromatin modification and genome regulation, cytoskeletal architecture and dynamics, membrane traffic, a range of evolutionary issues, telomerase structure and function, and the assembly and maintenance of cilia and basal bodies.

Other key roles of the Conference include disseminating recent technological developments in working with Ciliates, and exploring the use of Ciliates in innovative educational programs. The attendees, who come from laboratories throughout the world, include established researchers in the field as well as scientists who are just beginning to explore Ciliates as model systems, in addition to postdocs, and both graduate and undergraduate students.

FASEB SRC has announced a total of 34 SRCs in 2013. To register for an SRC, view preliminary programs, or find a listing of all our 2013 SRCs, please visit http://www.faseb.org/SRC.

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Since 1982, FASEB SRC has offered a continuing series of inter-disciplinary exchanges that are recognized as a valuable complement to the highly successful society meetings. Divided into small groups, scientists from around the world meet intimately and without distractions to explore new approaches to those research areas undergoing rapid scientific changes.

In efforts to expand the SRC series, potential organizers are encouraged to contact SRC staff. Proposal guidelines can be found at http://www.faseb.org/SRC.

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FASEB SRC announces conference registration open for: Ciliate Molecular Biology

FASEB SRC announces conference registration open for: Biology of Cilia and Flagella

Public release date: 4-Feb-2013 [ | E-mail | Share ]

Contact: Robin Crawford src@faseb.org 301-634-7010 Federation of American Societies for Experimental Biology

Bethesda, MD The Federation of American Societies for Experimental Biology (FASEB) announces the opening of registration for the Science Research Conference (SRC): Biology of Cilia and Flagella.

The 2013 Biology of Cilia and Flagella Conference is an important and unique scientific conference where basic and translational research intersect to drive rapid advances in the field of cilia/flagella and human ciliopathies. The underlying theme of the 2013 conference is the intriguing dance between basic research in model systems and clinical research in human disease syndromes. This conference will provide a venue for intense scientific discussion of recent advances in cilia and flagella biology and foster collaborations between researchers from around the world interested in basic, clinical, and developmental relevance of the cilium.

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FASEB SRC has announced a total of 34 SRCs in 2013. To register for an SRC, view preliminary programs, or find a listing of all our 2013 SRCs, please visit http://www.faseb.org/SRC.

Since 1982, FASEB SRC has offered a continuing series of inter-disciplinary exchanges that are recognized as a valuable complement to the highly successful society meetings. Divided into small groups, scientists from around the world meet intimately and without distractions to explore new approaches to those research areas undergoing rapid scientific changes.

In efforts to expand the SRC series, potential organizers are encouraged to contact SRC staff at SRC@faseb.org. Proposal guidelines can be found at http://www.faseb.org/SRC.

FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. FASEB enhances the ability of scientists and engineers to improvethrough their researchthe health, well-being and productivity of all people. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.

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FASEB SRC announces conference registration open for: Biology of Cilia and Flagella

FASEB SRC announces conference: Glucose transport — Gateway for Metabolic Systems Biology

Public release date: 4-Feb-2013 [ | E-mail | Share ]

Contact: Robin Crawford, CMP src@faseb.org 301-634-7010 Federation of American Societies for Experimental Biology

Bethesda, MD The Federation of American Societies for Experimental Biology (FASEB) announces the opening of registration for the Science Research Conference (SRC): Glucose transport: Gateway for Metabolic Systems Biology.

The 2013 FASEB Science Research Conference "Glucose transport: Gateway for Metabolic Systems Biology" is a unique conference where the role of glucose transport in the control of cellular growth and proliferation, and of whole organism metabolic homeostasis, are explored through formal talks, posters and discussions in an informal setting conductive to scientific interaction.

Sessions spanning from atomic mechanisms of glucose transport to systems biology of energy metabolism will be delivered by experts from around the world, and chaired by experienced, leading investigators in each field. An important theme of this conference will be the impact of glucose metabolism research on medically relevant problems such as type 2 diabetes and cancer. To insure timely discussion of emerging information, approximately 30% of the program will be chosen from submitted abstracts.

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FASEB SRC has announced a total of 34 SRCs in 2013. To register for an SRC, view preliminary programs, or find a listing of all our 2013 SRCs, please visit http://www.faseb.org/SRC.

Since 1982, FASEB SRC has offered a continuing series of inter-disciplinary exchanges that are recognized as a valuable complement to the highly successful society meetings. Divided into small groups, scientists from around the world meet intimately and without distractions to explore new approaches to those research areas undergoing rapid scientific changes.

In efforts to expand the SRC series, potential organizers are encouraged to contact SRC staff at SRC@faseb.org. Proposal guidelines can be found at http://www.faseb.org/SRC.

FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. FASEB enhances the ability of scientists and engineers to improvethrough their researchthe health, well-being and productivity of all people. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.

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FASEB SRC announces conference: Glucose transport -- Gateway for Metabolic Systems Biology

FASEB SRC announces conference registration open: The Biology of Calpains in Health and Disease

Public release date: 4-Feb-2013 [ | E-mail | Share ]

Contact: Robin Crawford src@faseb.org 301-634-7010 Federation of American Societies for Experimental Biology

Bethesda, MD The Federation of American Societies for Experimental Biology (FASEB) announces the opening of registration for the Science Research Conference (SRC): The Biology of Calpains in Health and Disease.

The 2013 FASEB Science Research Conference on The Biology of Calpains in Health and Disease brings together investigators from a wide range of disciplines to focus on the biology of calpains and understanding and treating diseases that involve these proteins. The conference will cover a diversity of topics ranging from bioinformatics of calpain substrates, calpains and signal transduction, role of calpains in cell and tissue degeneration, and contributions of calpains to various disorders. In addition to invited speakers from around the world presenting cutting edge research, a feature of this meeting is "New and Notable" talks in which the most exciting abstracts will be selected to for platform presentations. This provides a forum for young investigators and will include the most current research in the field.

FASEB SRC has announced a total of 34 SRCs in 2013. To register for an SRC, view preliminary programs, or find a listing of all our 2013 SRCs, please visit http://www.faseb.org/SRC.

###

Since 1982, FASEB SRC has offered a continuing series of inter-disciplinary exchanges that are recognized as a valuable complement to the highly successful society meetings. Divided into small groups, scientists from around the world meet intimately and without distractions to explore new approaches to those research areas undergoing rapid scientific changes.

In efforts to expand the SRC series, potential organizers are encouraged to contact SRC staff. Proposal guidelines can be found at http://www.faseb.org/SRC.

FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. FASEB enhances the ability of scientists and engineers to improvethrough their researchthe health, well-being and productivity of all people. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.

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FASEB SRC announces conference registration open: The Biology of Calpains in Health and Disease

FASEB SRC announces conference registration open for: Biology and Chemistry of Vision

Public release date: 4-Feb-2013 [ | E-mail | Share ]

Contact: Robin Crawford src@faseb.org 301-634-7010 Federation of American Societies for Experimental Biology

Bethesda, MD The Federation of American Societies for Experimental Biology (FASEB) announces the opening of registration for the Science Research Conference (SRC): Biology and Chemistry of Vision.

Since its inception in 1985, the Biology and Chemistry of Vision FASEB Science Research Conference has been one of the premier and most successful meetings focused on photoreceptor biology. The upcoming 2013 meeting will highlight the most recent advances in a broad and diverse range of photoreceptor function issues.

This meeting brings together premier senior and junior investigators of different expertise to discuss pigment and retinoid turnover, the biochemistry and physiology of phototransduction, photoreceptor cell biology and development, synaptic transmission, and invertebrate vision, as well as vision disorders, animal models, and therapy. In keeping with the success in past meetings, the 2013 conference will continue to emphasize close and intense scientific interactions among the participants, especially between senior and junior investigators.

FASEB SRC has announced a total of 34 SRCs in 2013. To register for an SRC, view preliminary programs, or find a listing of all our 2013 SRCs, please visit http://www.faseb.org/SRC.

###

Since 1982, FASEB SRC has offered a continuing series of inter-disciplinary exchanges that are recognized as a valuable complement to the highly successful society meetings. Divided into small groups, scientists from around the world meet intimately and without distractions to explore new approaches to those research areas undergoing rapid scientific changes.

In efforts to expand the SRC series, potential organizers are encouraged to contact SRC staff. Proposal guidelines can be found at http://www.faseb.org/SRC.

FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. FASEB enhances the ability of scientists and engineers to improvethrough their researchthe health, well-being and productivity of all people. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.

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FASEB SRC announces conference registration open for: Biology and Chemistry of Vision

Eric Finzi Face of Emotion Talk Part 1 Jan 29 2013 – Video


Eric Finzi Face of Emotion Talk Part 1 Jan 29 2013
Dr. Eric Finzi discusses his new book, "Face of Emotion: How Botox Affects Our Mood and Relationships" with a crowd at Politics and Prose Bookstore in Washington, DC, on January 29, 2013, the date of the book publication by Palgrave Macmillan Press. http://www.drfinzi.com Eric Finzi, MD, PhD BIOGRAPHY: Eric Finzi, MD, PhD, is the medical director and president of two dermatology practices, Chevy Chase Cosmetic Center in Chevy Chase, Maryland, and Dermatology and Cosmetic Surgery Associates in Greenbelt, Maryland. A true, modern day Renaissance man, Dr. Finzi is a board-certified dermasurgeon, with a PhD in biochemistry, and an accomplished artist and sculptor. His artwork has been exhibited worldwide in cities including New York City; Los Angeles; San Francisco; Chicago; Miami; Phoenix; Cologne, Germany; and Washington, DC, galleries. With the visual acuity and skilled hands of a sculptor, Dr. Finzi applies his artistic sensibility to his cosmetic dermatology practice by finely sculpting bodies and faces with a variety of high-tech, less-invasive, and safe methods including Tumescent liposuction, fat transfer, and Botox and dermal filler treatments. He also specializes in Mohs Micrographic surgery for the removal of skin cancers, utilizing his artistic ability to carefully reconstruct affected areas. The results are often life changing for the tens of thousands of people he has successfully treated since 1992. Dr. Finzi graduated summa cum laude with a BA degree in biology from ...

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Eric Finzi Face of Emotion Talk Part 1 Jan 29 2013 - Video

Discussion Video Series: Philosophy of Education – Video


Discussion Video Series: Philosophy of Education
What is your Philosophy of Education? What is the Role of the Instructor and Student? Three University of Lethbridge Faculty members discuss their views and passion for teaching and learning. Featuring: Robin Bright (Education), Ute Kothe (Chemistry Biochemistry), and Hillary Rodrigues (Religious Studies).

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Discussion Video Series: Philosophy of Education - Video

Eric Finzi Face of Emotion Talk Part 2 012913 – Video


Eric Finzi Face of Emotion Talk Part 2 012913
Dr. Eric Finzi talks to a crowd at Politics Prose about his new book, "Face of Emotion: How Botox Affects Our Mood Relationships," on January 29, 2013, the date of publication by Palgrave Macmillan Press. http://www.drfinzi.com Eric Finzi, MD, PhD, is the medical director and president of two dermatology practices, Chevy Chase Cosmetic Center in Chevy Chase, Maryland, and Dermatology and Cosmetic Surgery Associates in Greenbelt, Maryland. A true, modern day Renaissance man, Dr. Finzi is a board-certified dermasurgeon, with a PhD in biochemistry, and an accomplished artist and sculptor. His artwork has been exhibited worldwide in cities including New York City; Los Angeles; San Francisco; Chicago; Miami; Phoenix; Cologne, Germany; and Washington, DC, galleries. With the visual acuity and skilled hands of a sculptor, Dr. Finzi applies his artistic sensibility to his cosmetic dermatology practice by finely sculpting bodies and faces with a variety of high-tech, less-invasive, and safe methods including Tumescent liposuction, fat transfer, and Botox and dermal filler treatments. He also specializes in Mohs Micrographic surgery for the removal of skin cancers, utilizing his artistic ability to carefully reconstruct affected areas. The results are often life changing for the tens of thousands of people he has successfully treated since 1992. Dr. Finzi graduated summa cum laude with a BA degree in biology from the University of Pennsylvania. He received a full scholarship to Mount ...

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Eric Finzi Face of Emotion Talk Part 2 012913 - Video

TS Wiley: “I’m promising you quality of life.” – Video


TS Wiley: "I #39;m promising you quality of life."
TS Wiley promises improved quality of life for people using the Wiley Protocol. She also suggests that a part of "anti aging" is to be attached to your health. Wiley says preparing your own food, knowing where it comes from, is better for the body #39;s biochemistry.

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TS Wiley: "I'm promising you quality of life." - Video

Organization of the Cardiovascular System – Part 1 – Video


Organization of the Cardiovascular System - Part 1
http://www.SalmonellaPlace.com This is a tutorial/lecture on the Organization of the Cardiovascular System - Part 1. We cover some topics important for classes such as Biology, Biochemistry, Physiology, etc. If you have any questions, don #39;t be shy!! We hope we are able to clarify this topic. Enjoy! Plus, don #39;t forget to SUBSCRIBE for more! Facebook: http://www.facebook.com/salmonellaplace Twitter: http://www.twitter.com/thesalmonella Tumblr: http://www.salmonellaplace.tumblr.com

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Organization of the Cardiovascular System - Part 1 - Video

DNA: An Introduction to Genetics Part 1 – Video


DNA: An Introduction to Genetics Part 1
Please enjoy this basic introduction to genetics. I hope to give a simple overview of the basic biochemistry of DNA, how it is packaged into chromosomes, how genetic information is read to produce proteins and how mutations can cause disease. I have used simple analogies that attempt to make these concepts clearer and perhaps serve as a foundation to understand more complex topics. I am currently making a second video, exploring DNA replication, repair, transcription and protein translation to follow on from this. Thankyou for watching!

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DNA: An Introduction to Genetics Part 1 - Video

DNA: An Introduction to Genetics Part 2 – Video


DNA: An Introduction to Genetics Part 2
Please enjoy this basic introduction to genetics. I hope to give a simple overview of the basic biochemistry of DNA, how it is packaged into chromosomes, how genetic information is read to produce proteins and how mutations can cause disease. I have used simple analogies that attempt to make these concepts clearer and perhaps serve as a foundation to understand more complex topics. I am currently making a second video, exploring DNA replication, repair, transcription and protein translation to follow on from this. Thankyou for watching!

By: Lucy Richards

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DNA: An Introduction to Genetics Part 2 - Video

DNA: An Introduction to Genetics Part 3 – Video


DNA: An Introduction to Genetics Part 3
Please enjoy this basic introduction to genetics. I hope to give a simple overview of the basic biochemistry of DNA, how it is packaged into chromosomes, how genetic information is read to produce proteins and how mutations can cause disease. I have used simple analogies that attempt to make these concepts clearer and perhaps serve as a foundation to understand more complex topics. I am currently making a second video, exploring DNA replication, repair, transcription and protein translation to follow on from this. Thankyou for watching!

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DNA: An Introduction to Genetics Part 3 - Video

Macromolecular shredder for RNA: Researchers unravel the structure of the machinery for RNA disposal

Feb. 4, 2013 Much in the same way as we use shredders to destroy documents that are no longer useful or that contain potentially damaging information, cells use molecular machines to degrade unwanted or defective macromolecules. Scientists of the Max Planck Institute of Biochemistry in Martinsried near Munich, Germany, have now decoded the structure and the operating mechanism of the exosome, a macromolecular machine responsible for degradation of ribonucleic acids (RNAs) in eukaryotes.

RNAs are ubiquitous and abundant molecules with multiple functions in the cell. One of their functions is, for example, to permit translation of the genomic information into proteins. The results of the studies now published in the journal Nature show that the structural architecture and the main operation mode of the exosome are conserved in all domains of life.

Any errors that occur during the synthesis of RNA molecules or unwanted accumulation of RNAs can be damaging to the cell. The elimination of defective RNAs or of RNAs that are no longer needed are therefore key steps in the metabolism of a cell. The exosome, a multi-protein complex, is a key machine that shreds RNA into pieces. In addition, the exosome also processes certain RNA molecules into their mature form. However, the molecular mechanism of how the exosome performs these functions has been elusive.

A ubiquitous molecular shredder

Debora Makino, a postdoctoral researcher in the Research Department led by Elena Conti has now obtained an atomic resolution picture of the complete eukaryotic exosome complex bound to an RNA molecule. The structure of this complex allowed the scientists to understand how the exosome works. It is quite an elaborate machine: the exosome complex forms a hollow barrel formed by nine different proteins through which RNA molecules are threaded to reach a tenth protein, the catalytic subunit that then shreds the RNA into pieces, says Debora Makino. The barrel is essential for this process because it helps to unwind the RNA and prepares it for shredding. Cells lacking any of the ten proteins do not survive and this shows that not only the catalytic subunit but also the entire barrel is critical for the function of the exosome, Makino explains.

The RNA-binding and threading mechanism used by the exosome in eukaryotes is very similar to that of the exosome in bacteria and archaebacteria that the researchers had structurally characterized in earlier studies. Although the chemistry of the shredding reaction in eukaryotes is very different from that used in bacteria and archaebacteria, the channeling mechanism of the exosome is conserved, and conceptually similar to the channeling mechanism used by the proteasome, a complex for shredding proteins, says Elena Conti. In the future, the researchers want to understand how the exosome is selectively targeted by the RNAs earmarked for degradation and how it is regulated in the different cellular compartments.

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Macromolecular shredder for RNA: Researchers unravel the structure of the machinery for RNA disposal

Dr. Walter A. Scott, AIDS researcher, dies following stroke

Nearly 70, Dr. Walter A. Scott, a University of Miami biochemistry and molecular biology professor, wasnt thinking about retiring.

The lab was his life, said Dr. Gwendolyn Scott, his wife of 42 years

Scott, who conducted breakthrough HIV-AIDS research, joined the UM Miller School of Medicine faculty in 1975, and was constantly funded by National Institutes of Health, his wife said.

In early January, she said, hed just applied for another grant.

But Walter Scott died unexpectedly at Jackson Memorial Hospital on Jan. 28, just four days before his 70th birthday. His wife said he suffered a stroke at their Coral Gables home.

Born Feb. 1, 1943 in Los Angeles and raised in Oregon, Scott was known for his work on HIV resistance to the drug AZT, and for mentoring hundreds of students during nearly 40 years of running a molecular virology research lab at UMs Miller School.

Scott held a bachelors degree from the California Institute of Technology, and a doctorate in physiological chemistry from the University of Wisconsin, where he met his future wife, now a UM pediatrics professor whose work on mother-to-fetus AIDS transmission significantly reduced the disease in newborns.

She heads UMs Division of Pediatric Infectious Disease and Immunology.

Her husband loved nature, especially birding, she said. He loved the Everglades, listening to jazz and nurturing his students.

Scotts research focused on the biochemical mechanisms of viral replication and antiviral drug resistance, according to a UM news release. He directed the Pediatric Retro virology Laboratory for the Universitys National Institutes of Health-sponsored pediatric AIDS clinical trials networks, and belonged to the NIHs Virology Technical Advisory Committee for the Division of AIDS and of its Review Panel for AIDS Discovery and Development of Therapeutics.

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Dr. Walter A. Scott, AIDS researcher, dies following stroke

Leeza Gibbons leading the fight against Alzheimer's tells her side of the story in the March issue of Life Extension® …

FORT LAUDERDALE, Fla., Feb. 4, 2013 /PRNewswire/ --Best known for her role as anchor and reporter on television's Entertainment Tonight, these days Leeza Gibbons is becoming more recognized for working with Alzheimer's caregivers and their loved ones. In the March issue of Life Extension Magazine, Gibbons reveals her uphill battle caring for her mother suffering from this dreaded disease for the past 10 years.

(Logo: http://photos.prnewswire.com/prnh/20120223/FL58611LOGO-b )

As a result, Gibbons created an Alzheimer's caregiver empire of invaluable resources for the loved ones of Alzheimer's disease patients. In 2002, she formed The Leeza Gibbons Memory Foundation and Leeza's Place for caregivers.

As Gibbons told Life Extension Magazine, "We're not involved in the diagnosis or medical area of Alzheimer's. What we do is become partners with continuing care in the community. We align ourselves with hospitals and non-profits while our partners handle the medical side of things."

According to Gibbons' website, Leeza's Place is where family caregivers can become educated, empowered and energized, as well as interact with a support team to gain resources and create their own strategy of coping.

In addition to working with caregivers, the article also notes Gibbons' work with the science and scientists who are working to find a cure for the disease. Gibbons is using her appointment by former Calif. Gov. Arnold Schwarzenegger as an Alzheimer's Advocate to become more involved in the science aspect of an Alzheimer's cure.

Her participation with the renowned California Institute for Regenerative Medicine has put her at the door step of cutting-edge cures. Some of that research which has taken place at the University of California focuses on restoring memory in mice.

The Life Extension article also touches on Gibbons' involvement in dealing with a loved one's Alzheimer's diagnosis, and her take on a proper diet that includes dietary supplements.

The March issue of Life Extension Magazine is available at many leading book stores and supermarkets nationwide. For more information on how to obtain a copy of the magazine, visit http://www.lef.org or call Life Extension at 1-866-864-3027.

Life Extension Magazine is a monthly publication of the Life Extension Foundation Buyers Club with a readership of over 350,000. The magazine provides coverage of new discoveries involving anti-aging dietary supplements.

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Leeza Gibbons leading the fight against Alzheimer's tells her side of the story in the March issue of Life Extension® ...