British birds’ long-distance feats and longevity are revealed – The Guardian

Flying around the world may have become an unappealing prospect or a distant dream for most people during the coronavirus crisis.

If you are a Manx shearwater, however, there is no limit to your long-distance travel, and one of these small seabirds from the Hebridean isle of Rm was last year clocked journeying more than 7,564 miles from its Scottish breeding colony to the seaside resort of Las Grutas in Argentina.

An arctic skua from Scotland flew to Brazil a straight line of 6,845 miles while a swallow covered at least 6,400 to reach South Africa. A sanderling and a sandwich tern also made journeys of a similar length from Britain to South Africa.

The records were collected thanks to uniquely numbered rings fitted by volunteers to more than 1 million birds in Britain during 2019, enabling individuals to be identified for the rest of their lives.

The records, collected by the British Trust for Ornithology, provide insights into the remarkable migrations of birds but also the human and climatic pressures they face and their longevity.

Several species set new age records in 2019, including a fulmar humanely caught on Scotlands Sanda Island found to have a ring that was placed around its leg 41 years, 11 months and 17 days earlier. A siskin captured and ring-checked near the village of Tarbet in Argyll and Bute was found to have been ringed at the same site in 2010, making it the oldest known individual of its species.

A 50-year-old Manx shearwater caught by a ringer on Bardsey Island in Wales in 2008 holds the record as the longest-living wild bird in Britain after being ringed on the same small island in 1957.

Without fitting birds with uniquely numbered rings and monitoring their nests we wouldnt be able to follow their lives and our knowledge of them would be much poorer, said Rob Robinson of the BTO.

The data gathered by our fantastic volunteers help us to determine whether species are in trouble and, if they are, at what point of the lifecycle the problems are occurring.

Of 1,047,521 ringed birds, the most-ringed species was the blue tit, not known for its epic migrations. Second was the blackcap, traditionally a summer migrant which is now increasingly seen during winter because of global heating and the lure of garden bird feeders.

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British birds' long-distance feats and longevity are revealed - The Guardian

Should You Be Worried About Wayfair and Human Trafficking? – FLARE

As if 2020 couldnt get anymore bonkers. In a year thats already given usa global pandemic, the routinekilling of Black and Indigenous people by police and an overwhelming amount of Twitter content featuring realistic objects that are actually cake, we now have a conspiracy theory involving online furniture companies and child trafficking to contend with. On July 10, home furnishin retailer Wayfair started trending on Twitter and it was for a pretty nefarious reason. According to Mashable, on July 9, users onReddits r/conspiracy subreddit started positing that the siteor potentially third-party sellers on the sitewere secretly part of a child trafficking ring. And this didnt come out of nowhere. The theory started when a user posted a screenshot of abnormally high-priced cabinets from the Wayfairs site, noting that the names were unusual and unlike other furniture pieces on the site. According to those on the subreddit, a quick search of the names, which included monikers such as Neriah and Samiyah, found that they were the same names as several missing children.

Is it possible Wayfair involved in Human trafficking with their WFX Utility collection? Or are these just extremely overpriced cabinets? (Note the names of the cabinets) this makes me sick to my stomach if its true from conspiracy

This led many online to speculate and theorize a truly horrific allegation: that the company is engaged in child trafficking. Soon after starting on Reddit, the theories picked up steam on Instagram, Twitter and TikTok. Heres everything you need to know about the Wayfair child trafficking allegations.

For those who arent into interior design, or just really love Ikea (and who could blame you?), the name Wayfair may not be super familiar. Founded in 2002, the online home store sells furniture and accessories. And unlike Ikea and other furniture stores like Structube, many of the pieces sold on Wayfair.com are from different companies and not their own in-house brand.

This is far from the first time the company has come under scrutiny for reported bad behaviour. In June 2019, employees of the furniture brand walked off the job in protest of the companys low-key support of the Trump governments anti-migrant policy and detainment camps. ICYMI, Wayfair had a deal in which they provided government contractors with beds for the camps that house detained migrants at the United States border (camps that have been referred to by U.S. representative Alexandria Ocasio-Cortez as mass concentration camps). Despite the fact that at the time, Wayfair employees requested the company terminate this contract, the company did not oblige.

So yeah, not everyone are big fans of the companyand for very valid reasons.

As inhumane and wrong as the detainment camps in the U.S. are, these latest accusations against Wayfair are even more alarming. As mentioned above, theories that Wayfair is involved in human trafficking (specifically the trafficking of children) arose after a user noted utility closets and storage units for sale on the site, priced between $12,000 to $14,500price points they felt were exorbitant. Is it possible Wayfair involved in Human trafficking with their WFX Utility collection? the user wrote alongside a photo of the cabinets in question. Or are these just extremely overpriced cabinets? (Note the names of the cabinets) this makes me sick to my stomach if its true :(.

Read this next: All the Fashion Brands That Have Been Accused of Racism

Is it possible Wayfair involved in Human trafficking with their WFX Utility collection? Or are these just extremely overpriced cabinets? (Note the names of the cabinets) this makes me sick to my stomach if its true from conspiracy

Asfact-checking websiteSnopesnotes, because of this initial post, users online started to search for *other* home goods on the site that were similarly oddly priced. As the website notes, one user on Twitter shared a set of pillows and a shower curtain listed at $9,999 (which is a Drake-level price for something like pillow cases). When compared to similar itemslisted at only $99.99, for instancethe user decided that the discrepancy in prices must be attributed to the fact that the first listing was actually a listing for purchasing a child. The user tweeted (then deleted): If you search bungalow rose a bunch of shower curtains and pillows show up priced at $9,999. Wayfair is fucking trafficking children what the FUCK. Same with other things. They all have big price jumps to like 10 grand. Wayfair also supplies the furniture at ICE detention centers, where children are going MISSING from.

As Snopes statesin the same article: This claim is largely based on the idea that $10,000 is simply too expensive for a cabinet, and that there has to be some other explanation child trafficking to justify its cost.

More allegations soon cropped up on social media. Per MediaWisea Poynter-runnon-profit project that teaches Americans how to sort fact from fiction onlinemany Twitter users began claiming that searching the Stock Unit Number (SKU) for each Wayfair product on Russian search engine Yandex, which is similar to Google, brought up photos of female children. News organization Newsweek later reported this is untrue.

And, in addition to all of this, an additional theory arose regarding a specific 2016 review of a filing cabinet, priced at $5,000. PerNewsweek,in 2016 a user named Janna from Walnut Creek, CA (an area outside San Francisco), published a review on this particular product. (FWIW, Janne wrote: Checked many other sites and this was a great deal! Fast shipping. Thank you!). In February of this year, a man in Walnut Creek was arrested forhuman trafficking, child pornography and attempted kidnapping. According to The Mercury News, this arrest led to the uncovering of a much larger sex trafficking ring in the area.

What does a February 2020 arrest have to do with a 2016 review by someone who sounds like a lady from your moms book club? Nothing, most likely. But many people online have claimed the two incidents are linked.

Read this next: These Brands Have All Donated to Trumps Campaign

There have also been unsubstantiated and unverified reports that Wayfair CEO Niraj Shah has stepped down amid the allegations,which has only helped to fuel rumours of trafficking more. [In an email to FLARE, a spokesperson for the company said: Thereisno truth to that rumor, our CEO has not stepped down].

Perhaps because this Wayfair conspiracy theory is happening shortly after the arrest of Jeffrey Epstein co-conspirator and former GFGhislaine Maxwell, there have been attempts to connect Wayfair to the now-deceased disgraced billionaire. A 2003 photo of Maxwellwho was arrested on July 2 on charges that she helped recruit, groom and abuse minorshas gone viral in light of the allegations against the company, with many people online claiming that the man beside Maxwell is president of operations for Wayfair, Bill Hutcherson. But as Heavystates in a July 12 article, this claim is not true. An April 28, 2004 photo round-up in Tatlertaken at the December 2003 Aspreys New York Flagship launchin which Maxwell is wearing the same outfit and pictured with the same man, identifies him as George Bamford. Bamford is the founder of Bamford Watch Design, a company that launched in 2004 and which specializes in high-end watch customization.

In addition, Wayfair (which launched in 2002 under the name CSN Stores, according to Heavy), has never had a president of operations on its payroll. So, it would appear that the company doesnt have any overt links to Epstein and Maxwell.

According to Newsweek, who spoke with Reddit user PrincessPeach1987 (the user refused to reveal their real name), the theory originated after the poster began to search garage storage with their husband. The poster told Newsweek that while they were initially not suspicious of the pricing, additional posts on Facebook purporting similar scenarios caused them to become suspicious. According to the outlet, the user said they are involved in a local organization that helps victims of human trafficking, which has led them to be suspicious most of the time now. Per the outlet, they characterized their Reddit post as an effort to see if anyone else had more details.

Read this next: How a Borderline Personality Diagnosis Helped Me Understand Years of Heartache

The Wayfair conspiracy theory follows several other theories of international pedophilia rings involving celebrities and high-ranking officials, like Pizzagate.

Since news of the theory began circulating, the company has denied any involvement with child trafficking. In a statement to Newsweek, Wayfair said: There is, of course, no truth to these claims. The products in question are industrial grade cabinets that are accurately priced. Recognizing that the photos and descriptions provided by the supplier did not adequately explain the high price point, we have temporarily removed the products from site to rename them and to provide a more in-depth description and photos that accurately depict the product to clarify the price point.

Unlike the IRL facts and legitimate evidence against Wayfair when it came to outfitting migrant detainment camps, these latest theories appear to be untrue (and in fact, Snopes has labelled the allegations definitively as a hoax). Which is good to know and have clarified. Something else that should be made crystal clear? The fact that conspiracy theories like this are *extremely* dangerous. Not only does it spread massive disinformation (often to people who may not be aware of ways to properly fact-check these allegations) thanks in large part to the viral nature and longevity of content on the internet, but they also do a disservice to the very real and very harmful reality of human sex trafficking in North America.

In Canada, human traffickingespecially of children and teensis incredibly prevalent. 2016 data from Statistics Canada on human trafficking (the most recent stats to date) found that 72% victims of human trafficking were under 25 years old and90% of sex trafficking victims are females. And circulating unsubstantiated hoaxes like these minimize the importance of, not to mention detract attention and resources away from, these real victims and perpetrators. And, these unsubstantiated conspiracy theories can have almost dire consequences. In 2016, a North Carolina man walked into a Washington D.C. pizzeria with a semiautomatic rifle, handgun and a folding knife, under the guise that he was saving captive children from a satanic sex ring run by Hillary Clinton in the basement of the pizzeria, a theory reported by InfoWars host Alex Jones (InfoWars is a far-right American conspiracy theory and fake news website). As reported by Rolling Stonein a November 2017 article on the consequences of hoaxes and fake news, there were no children being held captive and the pizzeria didnt even have a basement.

Read this next: Heres Why TikTok May Get Banned in the US

The idea of a furniture company selling children is absolutely appallingand its entirely understandable that people would hear these allegations and get upset. Its also crucial that people look deeper into allegations and theories on the internet before posting or re-posting said claims.

FLARE has reached out to Wayfair for comment. The article will be updated with their response

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Should You Be Worried About Wayfair and Human Trafficking? - FLARE

Coping with the counterfeit parts menace during Covid – BusinessLine

As the world learns to live with Covid-19 and restrictions easing up, customers have gradually started commuting for essentials and, more importantly, their livelihoods.

Over the course of the lockdown, many vehicles have been stranded in parking spots. In the absence of conventional vehicle care and regular checks, there will be a surge in breakdowns. This will span across battery charging or replacement, brake lubrication, air-fuel system checks and repair, washing & disinfection, repair of electrical, and electronic parts as well as tyre replacements.

Dealerships will also have to address breakdown of engine fluids, corrosion of metal parts, deterioration of rubber parts, fading of colour panels, breaking in seat cover among others.

According to FICCI Cascade (Committee Against Smuggling and Counterfeiting Activities Destroying the Economy), 20 per cent of road accidents in India are caused by poor quality counterfeit parts. While automakers are putting their best foot forward to create a network of genuine parts, counterfeit trading continues to pose a challenge to growth and development of the component industry.

The issue of counterfeiting becomes especially critical for the two-wheeler industry. For one thing, India is the biggest two-wheeler market in the world with rural markets forming a significant part of demand. Manufacturers must ensure that they have a wide network pan India to provide the best after-sales service. After all, this boils down to protecting human lives.

Covid-19 has disrupted the transportation ecosystem and with social distancing being the need of the hour, consumer surveys indicate that people will now prefer personal vehicles to public transport. This is where there will be a growing demand for two-wheelers which, in turn, will boost demand for genuine spares.

Clearly, one big advantage that genuine parts offer is longevity. Even while they may be slightly pricer than counterfeit ones, the risk posed by the latter is damage in a short period of time which will also extend to supporting parts.

Consequently, this may require multiple replacements versus the one-time cost of the same genuine part. Additionally, a genuine part comes with warranty, replacement guarantee and longer life.

Safety is another important aspect to be factored in. Genuine parts are specifically designed, manufactured and rigorously tested. They form an integral component of the vehicle to meet high quality, safety and performance standards.

As a case in point, TVS Motor Company initiated a brand protection programme to protect customers against fraudulent practices. The objective was to ensure that vehicles did not develop a fault by being fitted with spurious spares.

With the third-party supplier often not accepting any accountability of damage caused by fake parts, it becomes a pain point for the owner of the vehicle to not only deal with damage but replacement of fake parts with genuine ones.

The brand protection programme, carried out with support from police in various states, identified and seized counterfeits of TVS Motor spares worth 7.5 crore across major cities and towns. The initiative has seen a positive impact in Tier 2/3 markets which, in turn, has contributed to the cause of customer safety. The programme has also ensured distribution and availability of genuine parts through TVS Motors 3,500 plus touch points.

The writer is Senior VP, Parts Business, TVS Motor Company

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Coping with the counterfeit parts menace during Covid - BusinessLine

Here’s How Bats Survive Novel Coronavirus and Other Deadly Viruses – The Weather Channel

Representational image

Bats are carriers of deadly viruses that affect humans like Ebola, rabies, and possibly the SARS-CoV-2 strain of virus that causes coronavirus. However, these viruses have not killed bats but humans.

Bats are remarkably able to tolerate viruses, and, additionally, live much longer than similar-sized land mammals. What are the secrets to their longevity and virus resistance?

According to researchers at the University of Rochester in the US, bats' longevity and capacity to tolerate viruses may stem from their ability to control inflammation, which is a hallmark of disease and aging.

In a study published in the journal Cell Metabolism, biology professors Vera Gorbunova and Andrei Seluanov described the mechanisms underlying bats' unique abilities and how these mechanisms may hold clues to developing new treatments for diseases in humans.

"There may be a very strong connection between bats' resistance to infectious diseases and their longevity. We also realised that bats can provide clues to human therapies used to fight diseases," said Gorbunova.

The scientists, along with colleague Brian Kennedy, director of the Centre for Healthy Aging at the National University of Singapore, got to talking about bats.

Unlike humans, bats have developed specific mechanisms that reduce viral replication and also dampen the immune response to a virus.

The result is a beneficial balance: their immune systems control viruses but at the same time, do not mount a strong inflammatory response.

Another factor may be their environment.

Many species of bats live in large, dense colonies, and hang close together on cave ceilings or in trees. Those conditions are ideal for transmitting viruses and other pathogens.

"Bats are constantly exposed to viruses. They are always flying out and bringing back something new to the cave or nest, and they transfer the virus because they live in such close proximity to each other," said Seluanov.

Because bats are constantly exposed to viruses, their immune systems are in a perpetual arms race with pathogens.

"Usually the strongest driver of new traits in evolution is an arms race with pathogens. Dealing with all of these viruses may be shaping bats' immunity and longevity".

However, the study does not suggest for humans to toss their masks and crowd together in restaurants and movie theatres.

Evolution takes place over thousands of years, rather than a few months.

While humans may be developing social habits that parallel those of bats, we have not yet evolved bats' sophisticated mechanisms to combat viruses as they emerge and swiftly spread.

"The consequences may be that our bodies experience more inflammation," said Gorbunova.

Studying bats' immune systems will provide new targets for human therapies to fight diseases and aging, said researchers.

For example, bats have mutated or completely eliminated several genes involved in inflammation; scientists can develop drugs to inhibit these genes in humans.

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Here's How Bats Survive Novel Coronavirus and Other Deadly Viruses - The Weather Channel

Scientists may have cracked the code to improve human longevity – Outlook India

Scientists may have cracked the code to improve human longevity

New York, July 13 (IANS) In a big breaking discovery, the researchers may have found the beginnings of a path toward increasing human lifespan.

The study, published in the Journal of Gerontology: Biological Sciences, shows the drug mifepristone can extend the lives of two very different species used in laboratory studies, suggesting the findings may apply to other species, including human beings.

Mifepristone, also known as RU-486, is used by clinicians to end early pregnancies as well as to treat cancer and Cushing disease.

Studying one of the most common laboratory models used in genetic research -- the fruit fly Drosophila -- the researchers found that the drug mifepristone extends the lives of female flies that have mated.

"Our data show that in Drosophila, mifepristone either directly or indirectly counteracts juvenile hormone signalling, but the exact target of mifepristone remains elusive," said study researchers from the University of Southern California in the US.

According to the researchers, during mating, female fruit flies receive a molecule called sex peptide from the male.

Previous research has shown that sex peptide causes inflammation and reduces the health and lifespan of female flies.

The research team found that feeding mifepristone to the fruit flies that have mated blocks the effects of sex peptide, reducing inflammation and keeping the female flies healthier, leading to longer lifespans than their counterparts who did not receive the drug.

The drug''s effects in Drosophila appear similar to those seen in women who take it.

"In the fly, mifepristone decreases reproduction, alters innate immune response and increases life span," the study researcher John Tower explained.

"In the human, we know that mifepristone decreases reproduction and alters the innate immune response, so might it also increase life span?" he added.

Seeking a better understanding of how mifepristone works to increase lifespan, the research team looked at the genes, molecules and metabolic processes that changed when flies consumed the drug.

They found that a molecule called juvenile hormone plays a central role. Juvenile hormone regulates the development of fruit flies throughout their life, from egg to larvae to adult.

Sex peptide appears to escalate the effects of juvenile hormone, shifting the mated flies'' metabolism from healthier processes to metabolic pathways that require more energy to maintain.

Further, the metabolic shift promotes harmful inflammation, and it appears to make the flies more sensitive to toxic molecules produced by bacteria in their microbiome.

Mifepristone changes all of that.

According to the researchers, when the mated flies ate the drug, their metabolism stuck with the healthier pathways, and they lived longer than their mated sisters who did not get mifepristone.

"Notably, these metabolic pathways are conserved in humans, and are associated with health and longevity," the study authors wrote.

--IANS

bu/na/in

Disclaimer :- This story has not been edited by Outlook staff and is auto-generated from news agency feeds. Source: IANS

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Scientists may have cracked the code to improve human longevity - Outlook India

What is love? – The Conversation AU

From songs and poems to novels and movies, romantic love is one of the most enduring subjects for artworks through the ages. But what about the science?

Historical, cultural and even evolutionary evidence suggests love existed during ancient times and across many parts of the world. Romantic love has been found to exist in 147 of 166 cultures looked at in one study.

The complexity of love has much to do with how people experience it differently and how it can change over time.

Read more: Friday essay: finding spaces for love

Psychological research over the past 50 years has investigated the differences between liking someone, loving someone and being in love.

Liking is described as having positive thoughts and feelings towards someone and finding that persons company rewarding. We often also experience warmth and closeness towards the people we like. In some instances we choose to be emotionally intimate with these people.

When we love someone we experience the same positive thoughts and experiences as when we like a person. But we also experience a deep sense of care and commitment towards that person.

Being in love includes all the above but also involves feelings of sexual arousal and attraction. However, research into peoples own views of love suggests that not all love is the same.

Romantic love consists of two types: passionate and companionate love. Most romantic relationships, whether they be heterosexual or same sex, involve both these parts.

Passionate love is what people typically consider being in love. It includes feelings of passion and an intense longing for someone, to the point they might obsessively think about wanting to be in their arms.

The second part is known as companionate love. Its not felt as intensely, but its complex and connects feelings of emotional intimacy and commitment with a deep attachment toward the romantic partner.

Research looking at changes in romantic love over time typically finds that although passionate love starts high, it declines over the course of a relationship.

There are various reasons for this.

As partners learn more about each other and become more confident in the long-term future of the relationship, routines develop. The opportunities to experience novelty and excitement can also decline, as can the frequency of sexual activity. This can cause passionate love to subside.

Although a reduction in passionate love is not experienced by all couples, various studies report approximately 20-40% of couples experience this downturn. Of couples who have been married in excess of ten years, the steepest downturn is most likely to occur over the second decade.

Life events and transitions can also make it challenging to experience passion. People have competing responsibilities which affect their energy and limit the opportunities to foster passion. Parenthood is an example of this.

Read more: Love by design: when science meets sex, lust, attraction and attachment

In contrast, companionate love is typically found to increase over time.

Although research finds most romantic relationships consist of both passionate and companionate love, its the absence or reductions in companionate love, moreso than passionate love, that can negatively affect the longevity of a romantic relationship.

Love is an emotion that keeps people bonded and committed to one another. From an evolutionary psychology perspective, love evolved to keep the parents of children together long enough for them to survive and reach sexual maturity.

Read more: What is this thing called love?

The period of childhood is much longer for humans than other species. As offspring rely on adults for many years to survive and to develop the skills and abilities needed for successful living, love is especially important for humans.

Without love, its difficult to see how the human species could have evolved.

Not only is there an evolutionary foundation to love, love is rooted in biology. Neurophysiological studies into romantic love show that people who are in the throes of passionate love experience increased activation in brain regions associated with reward and pleasure.

Read more: Love lockdown: the pandemic has put pressure on many relationships, but here's how to tell if yours will survive

In fact, the brain regions activated are the same as those activated by cocaine.

These regions release chemicals such as oxytocin, vasopressin and dopamine, which produce feelings of happiness and euphoria that are also linked to sexual arousal and excitement.

Interestingly, these brain regions are not activated when thinking about non-romantic relationships such as friends. These findings tell us that liking someone is not the same as being in love with someone.

Research has found three primary styles of love. First coined by psychologist John Lee, the love styles are eros, ludus and storge. These styles include peoples beliefs and attitudes about love and act as a guide for how to approach romantic relationships.

Eros

This style of love refers to erotic love and is focused on physical attraction and engaging in sex, the quick development of strong and passionate feelings for another and intense intimacy.

Ludus

This style involves being emotionally distant and often involves game-playing. Its not surprising people who endorse this love style are unlikely to commit, feel comfortable ending relationships and often start a new relationship before ending the current one.

Storge

Storge is often regarded as a more mature form of love. Priority is given to having a relationship with a person who has similar interests, affection is openly expressed and there is less emphasis on physical attractiveness. People high on storge love are trusting of others and are not needy or dependent on others.

You may see yourself in more than one of these styles.

Evidence suggests some people possess a mixture of the three main love styles; these mixtures were labelled by Lee as mania, pragma and agape.

Read more: Darling, I love you ... from the bottom of my brain

Manic love includes intense feelings for a partner as well as worry about committing to the relationship. Pragmatic love involves making sensible relationship choices in finding a partner who will make a good companion and friend. Agape is a self-sacrificing love that is driven by a sense of duty and selflessness.

A persons love style has little to do with their genetics. Rather, its associated with the development of personality and a persons past relationship experiences.

Some studies have found people who are high on dark traits, such as narcissism, psychopathy and machiavellianism, endorse more of a ludus or pragma love style.

Read more: There are six styles of love. Which one best describes you?

People who have an insecure attachment style, involving a high need for validation and preoccupation with relationship partners, endorse more mania love, while those who are uncomfortable with intimacy and closeness do not endorse eros love.

No matter the differences in the way love is experienced, one thing remains common for all: we as humans are social animals who have a deep fascination for it.

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What is love? - The Conversation AU

Nope, every dog year isn’t equal to 7 human years, researchers now say – WXII The Triad

How do you compare a dog's age to that of a person? A popular method says you should multiply the dog's age by 7 to compute how old Fido is in "human years."But new research published Thursday in the Cell Systems journal debunks that method. And that's because the scientists behind a new study say dogs and humans don't age at the same rate.Researchers at the University of California San Diego School of Medicine have developed a new formula that takes into account that variance. Tracking molecular changes in the DNA of Labrador retrievers, and in particular "the changing patterns of methyl groups" in their genome, according to a release, the study shows how dogs age at a much faster rate than humans early in their lives, then slow down after reaching maturity."This makes sense when you think about it after all, a nine-month-old dog can have puppies, so we already knew that the 1:7 ratio wasn't an accurate measure of age," lead author Trey Ideker is quoted as saying.Based on the study, a one-year-old dog compares to a 30-year-old human, a four-year-old dog to a 52-year-old human. The rate of aging decreases after dogs turn 7.The new formula "is the first that is transferable across species," and scientists plan to test their findings on other dog breeds to study the impact of longevity on their findings, according to a release.Researchers also believe that observing changes in the methylation patterns before and after the use of anti-aging products could help veterinarians make more informed decisions in terms of diagnostics and treatment.A graphic in the study makes the age comparisons intuitive and provides some helpful context for dog owners, including the scientists themselves."I have a six-year-old dog she still runs with me, but I'm now realizing that she's not as 'young' as I thought she was," Ideker is quoted as saying.

How do you compare a dog's age to that of a person? A popular method says you should multiply the dog's age by 7 to compute how old Fido is in "human years."

But new research published Thursday in the Cell Systems journal debunks that method. And that's because the scientists behind a new study say dogs and humans don't age at the same rate.

Researchers at the University of California San Diego School of Medicine have developed a new formula that takes into account that variance. Tracking molecular changes in the DNA of Labrador retrievers, and in particular "the changing patterns of methyl groups" in their genome, according to a release, the study shows how dogs age at a much faster rate than humans early in their lives, then slow down after reaching maturity.

"This makes sense when you think about it after all, a nine-month-old dog can have puppies, so we already knew that the 1:7 ratio wasn't an accurate measure of age," lead author Trey Ideker is quoted as saying.

Based on the study, a one-year-old dog compares to a 30-year-old human, a four-year-old dog to a 52-year-old human. The rate of aging decreases after dogs turn 7.

The new formula "is the first that is transferable across species," and scientists plan to test their findings on other dog breeds to study the impact of longevity on their findings, according to a release.

Researchers also believe that observing changes in the methylation patterns before and after the use of anti-aging products could help veterinarians make more informed decisions in terms of diagnostics and treatment.

A graphic in the study makes the age comparisons intuitive and provides some helpful context for dog owners, including the scientists themselves.

"I have a six-year-old dog she still runs with me, but I'm now realizing that she's not as 'young' as I thought she was," Ideker is quoted as saying.

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Nope, every dog year isn't equal to 7 human years, researchers now say - WXII The Triad

Research On Global Genomic Biomarker Market (impact of COVID-19) with Top Players: Bio-Rad,Beckman Coulter,Myriad Genetics and Others – Owned

Global Genomic Biomarker Market: Trends Estimates High Demand by 2027

The Genomic Biomarker Market 2020 report includes the market strategy, market orientation, expert opinion and knowledgeable information. The Genomic Biomarker Industry Report is an in-depth study analyzing the current state of the Genomic Biomarker Market. It provides a brief overview of the market focusing on definitions, classifications, product specifications, manufacturing processes, cost structures, market segmentation, end-use applications and industry chain analysis. The study on Genomic Biomarker Market provides analysis of market covering the industry trends, recent developments in the market and competitive landscape.

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The final report will add the analysis of the Impact of Covid-19 in this report Genomic Biomarker industry.

Some of The Companies Competing in The Genomic Biomarker Market are: Bio-Rad,Beckman Coulter,Myriad Genetics,Thermo Fisher Scientific,Roche,QIAGEN,Epigenomics,Almac,Pfizer,Human Longevity,ValiRx,Personalis,Eagle Genomics,Empire Genomics,Agilent,Illumina.

Get a Sample Copy of the [emailprotected] https://www.reportsandmarkets.com/sample-request/global-genomic-biomarker-market-size-status-and-forecast-2019-2025?utm_source=jewishlifenews&utm_medium=46

The report scrutinizes different business approaches and frameworks that pave the way for success in businesses. The report used Porters five techniques for analyzing the Genomic Biomarker Market; it also offers the examination of the global market. To make the report more potent and easy to understand, it consists of info graphics and diagrams. Furthermore, it has different policies and improvement plans which are presented in summary. It analyzes the technical barriers, other issues, and cost-effectiveness affecting the market.

Global Genomic Biomarker Market Research Report 2020 carries in-depth case studies on the various countries which are involved in the Genomic Biomarker market. The report is segmented according to usage wherever applicable and the report offers all this information for all major countries and associations. It offers an analysis of the technical barriers, other issues, and cost-effectiveness affecting the market. Important contents analyzed and discussed in the report include market size, operation situation, and current & future development trends of the market, market segments, business development, and consumption tendencies. Moreover, the report includes the list of major companies/competitors and their competition data that helps the user to determine their current position in the market and take corrective measures to maintain or increase their share holds.

What questions does the Genomic Biomarker market report answer pertaining to the regional reach of the industry?

The report claims to split the regional scope of the Genomic Biomarker market into North America, Europe, Asia-Pacific, South America & Middle East and Africa. Which among these regions has been touted to amass the largest market share over the anticipated duration

How do the sales figures look at present how does the sales scenario look for the future?

Considering the present scenario, how much revenue will each region attain by the end of the forecast period?

How much is the market share that each of these regions has accumulated presently

How much is the growth rate that each topography will depict over the predicted timeline

A short overview of the Genomic Biomarker market scope:

Global market remuneration

Overall projected growth rate

Industry trends

Competitive scope

Product range

Application landscape

Supplier analysis

Marketing channel trends Now and later

Sales channel evaluation

Market Competition Trend

Market Concentration Rate

Reasons to Read this Report

This report provides pin-point analysis for changing competitive dynamics

It provides a forward looking perspective on different factors driving or restraining market growth

It provides a six-year forecast assessed on the basis of how the market is predicted to grow

It helps in understanding the key product segments and their future

It provides pin point analysis of changing competition dynamics and keeps you ahead of competitors

It helps in making informed business decisions by having complete insights of market and by making in-depth analysis of market segments

TABLE OF CONTENT:

Chapter 1:Genomic Biomarker Market Overview

Chapter 2: Global Economic Impact on Industry

Chapter 3:Genomic Biomarker Market Competition by Manufacturers

Chapter 4: Global Production, Revenue (Value) by Region

Chapter 5: Global Supply (Production), Consumption, Export, Import by Regions

Chapter 6: Global Production, Revenue (Value), Price Trend by Type

Chapter 7: Global Market Analysis by Application

Chapter 8: Manufacturing Cost Analysis

Chapter 9: Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10: Marketing Strategy Analysis, Distributors/Traders

Chapter 11: Genomic Biomarker Market Effect Factors Analysis

Chapter 12: GlobalGenomic Biomarker Market Forecast to 2027

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Research On Global Genomic Biomarker Market (impact of COVID-19) with Top Players: Bio-Rad,Beckman Coulter,Myriad Genetics and Others - Owned

Peonage Explained: The system of convict labor was Slavery by another name – Milwaukee Independent

The Obama administration pursued a plan to reform it. An entire news organization, The Marshall Project, was launched in late 2014 to cover it. Organizations like Black Lives Matter and The Sentencing Project are dedicated to unmaking a system that unjustly targets people of color.

But how did we get this system in the first place? Our ongoing historical research project investigates the relationship between the press and convict labor. While that story is still unfolding, we have learned what few Americans, especially white Americans, know: the dark history that produced our current criminal justice system.

If anything is to change if we are ever to end this racial nightmare, and achieve our country, as James Baldwin put it we must confront this system and the blighted history that created it.

During Reconstruction, the 12 years following the end of the Civil War and the abolition of slavery, former slaves made meaningful political, social and economic gains. Black men voted and even held public office across the South. Biracial experiments in governance flowered. Black literacy surged, surpassing those of whites in some cities. Black schools, churches and social institutions thrived.

As the prominent historian Eric Foner writes in his masterwork on Reconstruction, Black participation in Southern public life after 1867 was the most radical development of the Reconstruction years, a massive experiment in interracial democracy without precedent in the history of this or any other country that abolished slavery in the nineteenth century.

But this moment was short-lived. As W.E.B. Du Bois wrote, the slave went free; stood a brief moment in the sun; then moved back again toward slavery.

History is made by human actors and the choices they make.

According to Douglas Blackmon, author of Slavery by Another Name, the choices made by Southern white supremacists after abolition, and the rest of the countrys accommodation, explain more about the current state of American life, black and white, than the antebellum slavery that preceded.

Designed to reverse black advances, Redemption was an organized effort by white merchants, planters, businessmen and politicians that followed Reconstruction. Redeemers employed vicious racial violence and state legislation as tools to prevent black citizenship and equality promised under the 14th and 15th amendments.

By the early 1900s, nearly every southern state had barred black citizens not only from voting but also from serving in public office, on juries and in the administration of the justice system.

The Souths new racial caste system was not merely political and social. It was thoroughly economic. Slavery had made the Souths agriculture-based economy the most powerful force in the global cotton market, but the Civil War devastated this economy. How to build a new one?

Ironically, white leaders found a solution in the 13th Amendment, which ended slavery in the United States in 1865. By exploiting the provision allowing slavery and involuntary servitude to continue as a punishment for crime, they took advantage of a penal system predating the Civil War and used even during Reconstruction.

A new form of control

With the help of profiteering industrialists they found yet a new way to build wealth on the bound labor of black Americans: the convict lease system. Heres how it worked. Black men and sometimes women and children were arrested and convicted for crimes enumerated in the Black Codes, state laws criminalizing petty offenses and aimed at keeping freed people tied to their former owners plantations and farms. The most sinister crime was vagrancy the crime of being unemployed which brought a large fine that few blacks could afford to pay.

Black convicts were leased to private companies, typically industries profiteering from the regions untapped natural resources. As many as 200,000 black Americans were forced into back-breaking labor in coal mines, turpentine factories and lumber camps. They lived in squalid conditions, chained, starved, beaten, flogged and sexually violated. They died by the thousands from injury, disease and torture.

For both the state and private corporations, the opportunities for profit were enormous. For the state, convict lease generated revenue and provided a powerful tool to subjugate African-Americans and intimidate them into behaving in accordance with the new social order. It also greatly reduced state expenses in housing and caring for convicts. For the corporations, convict lease provided droves of cheap, disposable laborers who could be worked to the extremes of human cruelty.

Every southern state leased convicts, and at least nine-tenths of all leased convicts were black. In reports of the period, the terms convicts and negroes are used interchangeably.

Of those black Americans caught in the convict lease system, a few were men like Henry Nisbet, who murdered nine other black men in Georgia. But the vast majority were like Green Cottenham, the central figure in Blackmons book, who was snatched into the system after being charged with vagrancy.

A principal difference between antebellum slavery and convict leasing was that, in the latter, the laborers were only the temporary property of their masters. On one hand, this meant that after their fines had been paid off, they would potentially be let free. On the other, it meant the companies leasing convicts often absolved themselves of concerns about workers longevity. Such convicts were viewed as disposable and frequently worked beyond human endurance.

The living conditions of leased convicts are documented in dozens of detailed, firsthand reports spanning decades and covering many states. In 1883, Blackmon writes, Alabama prison inspector Reginald Dawson described leased convicts in one mine being held on trivial charges, in desperate, miserable conditions, poorly fed, clothed, and unnecessarily chained and shackled. He described the appalling number of deaths and appalling numbers of maimed and disabled men held by various forced-labor entrepreneurs spanning the entire state.

Dawsons reports had no perceptible impact on Alabamas convict leasing system. The exploitation of black convict labor by the penal system and industrialists was central to southern politics and economics of the era. It was a carefully crafted answer to black progress during Reconstruction highly visible and widely known. The system benefited the national economy, too. The federal government passed up one opportunity after another to intervene.

Convict lease ended at different times across the early 20th century, only to be replaced in many states by another racialized and brutal method of convict labor: the chain gang. Convict labor, debt peonage, lynching and the white supremacist ideologies of Jim Crow that supported them all produced a bleak social landscape across the South for African-Americans.

Black Americans developed multiple resistance strategies and gained major victories through the civil rights movement, including Brown v. Board of Education, the Civil Rights Act and the Voting Rights Act. Jim Crow fell, and America moved closer than ever to fulfilling its democratic promise of equality and opportunity for all.

But in the decades that followed, a tough on crime politics with racist undertones produced, among other things, harsh drug and mandatory minimum sentencing laws that were applied in racially disparate ways. The mass incarceration system exploded, with the rate of imprisonment quadrupling between the 1970s and today. Michelle Alexander famously calls it The New Jim Crow in her book of the same name.

Today, the U.S. has the highest incarceration rate of any country in the world, with 2.2 million behind bars, even though crime has decreased significantly since the early 1990s. And while black Americans make up only 13 percent of the U.S. population, they make up 37 percent of the incarcerated population. Forty percent of police killings of unarmed people are black men, who make up merely 6 percent of the population. It doesnt have to be this way. We can choose otherwise.

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Peonage Explained: The system of convict labor was Slavery by another name - Milwaukee Independent

Precision Medicine Software Market Size Prognosticated to Perceive a Thriving Growth by 2026 | Synapse, Inc., PierianDx, Inc. – Morning Tick

According to a new report published by Allied Market Research, titled, Precision Medicine Software Marketby Delivery Mode (On-premise and Cloud-based), Application (Oncology, Pharmacogenomics, Rare Diseases, and Others), and End User (Healthcare Providers, Research Centers & Government Institutes, and Pharmaceutical & Biotechnology Companies): Global Opportunity Analysis and Industry Forecast, 2019-2026

Precision medicine is an emerging medical approach undertaken by medical practitioners for the treatment of a patient, followed with medical decisions, treatments, practices, or products being tailored to the individual patient. Appropriate or optimal therapies may be employed based on variability in the patients genetic profile, environment, and lifestyle for each person. The diagnostic testing can be based on the context of an individuals genetic profile or other molecular or cellular analysis. The emergence of precision medicine has addressed the dire need for better diagnostic and analytical tools. Precision medicine software combines the clinical and molecular data to provide with valuable insights to determine the ideal therapeutic course of treatment.

Download Report Sample @https://www.alliedmarketresearch.com/request-sample/5675

Moreover, it provides with a wide range of applications in both the diagnostics and clinical areas for better understanding of diseases such as cancer, searching for new biomarkers, researching new therapies, repurposing existing drugs, and stratifying patients for clinical trials.

The global market size of Precision Medicine Software Market is $XX million in 2018 with XX CAGR, and it is expected to reach $XX million by the end of 2026 with a CAGR of XX% from 2019 to 2026.

The Major Key Players Are:

Synapse, Inc., Allscripts Healthcare Solutions, Inc. (2bPrecise LLC), Roche Holdings, Inc. (Foundation Medicine, Inc.), Fabric Genomics, Inc., Sophia Genetics SA, PierianDx, Inc., Qiagen N.V. (N-of-One, Inc.), Human Longevity, Inc., Roper Technologies, Inc. (Sunquest Information Systems, Inc.), Gene42, Inc. Other players in the value chain include Translational Software, Inc., LifeOmic Health, LLC, NantHealth, Inc., Tempus Labs, Inc., Flatiron Health, Inc., IBM Watson Group, and Koninklijke Philips N.V.

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Precision Medicine Software Market Size Prognosticated to Perceive a Thriving Growth by 2026 | Synapse, Inc., PierianDx, Inc. - Morning Tick

Adrenomyeloneuropathy Treatment Market Growth by Top Companies, Trends by Types and Application, Forecast to 2026|Novadip Biosciences, Eureka…

Adrenomyeloneuropathy Treatment

In a recent study published by QY Research, titled Global Adrenomyeloneuropathy Treatment MarketResearch Report, analysts offer an in-depth analysis of the global Adrenomyeloneuropathy Treatment market. The study analyzes the various aspects of the market by studying its historic and forecast data. The research report provides a Porters five force model, SWOT analysis, and PESTEL analysis of the Adrenomyeloneuropathy Treatment market. The different areas covered in the report are Adrenomyeloneuropathy Treatment market size, drivers and restraints, segment analysis, geographic outlook, major manufacturers in the market, competitive landscape, value/volume data, marketing strategies, and expert views

Major Key Player operating in this report are: Ascend Biopharmaceuticals, Novadip Biosciences, Eureka Therapeutics, Human Longevity, Regeneus, Allogene Therapeutics, BioRestorative Therapies, Immatics Biotechnologies, NewLink Genetics, Cytori Therapeutics, Talaris Therapeutics Adrenomyeloneuropathy Treatment

Get PDF Sample Copy of the Report to understand the structure of the complete report: (Including Full TOC, List of Tables & Figures, Chart) :

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Segmental Analysis

The report has classified the global Adrenomyeloneuropathy Treatment industry into segments including product type and application. Every segment is evaluated based on growth rate and share. Besides, the analysts have studied the potential regions that may prove rewarding for the Adrenomyeloneuropathy Treatment manufacturers in the coming years. The regional analysis includes reliable predictions on value and volume, thereby helping market players to gain deep insights into the overall Adrenomyeloneuropathy Treatment industry.

Global Adrenomyeloneuropathy Treatment Market Segment By Type:

End Users, Hospitals, Clinics, Ambulatory Surgical Centers, Others

Global Adrenomyeloneuropathy Treatment Market Segment By Application:

Since the COVID-19 virus outbreak in December 2019, the disease has spread to almost 100 countries around the globe with the World Health Organization declaring it a public health emergency. The global impacts of the coronavirus disease 2019 (COVID-19) are already starting to be felt, and will significantly affect the Adrenomyeloneuropathy Treatment market in 2020. COVID-19 can affect the global economy in three main ways: by directly affecting production and demand, by creating supply chain and market disruption, and by its financial impact on firms and financial markets. The outbreak of COVID-19 has brought effects on many aspects, like flight cancellations; travel bans and quarantines; restaurants closed; all indoor events restricted; over forty countries state of emergency declared; massive slowing of the supply chain; stock market volatility; falling business confidence, growing panic among the population, and uncertainty about future. This report also analyses the impact of Coronavirus COVID-19 on the Adrenomyeloneuropathy Treatment industry. Based on our recent survey, we have several different scenarios about the Adrenomyeloneuropathy Treatment YoY growth rate for 2020. The probable scenario is expected to grow by a xx% in 2020 and the revenue will be xx in 2020 from US$ xx million in 2019. The market size of Adrenomyeloneuropathy Treatment will reach xx in 2026, with a CAGR of xx% from 2020 to 2026. With industry-standard accuracy in analysis and high data integrity, the report makes a brilliant attempt to unveil key opportunities available in the global Adrenomyeloneuropathy Treatment market to help players in achieving a strong market position. Buyers of the report can access verified and reliable market forecasts, including those for the overall size of the global Adrenomyeloneuropathy Treatment market in terms of revenue. Players, stakeholders, and other participants in the global Adrenomyeloneuropathy Treatment market will be able to gain the upper hand as they use the report as a powerful resource. For this version of the report, the segmental analysis focuses on revenue and forecast by each end users segment in terms of revenue and forecast by each therapy segment in terms of revenue for the period 2015-2026. Regional and Country-level Analysis The report offers an exhaustive geographical analysis of the global Adrenomyeloneuropathy Treatment market, covering important regions, viz, North America, Europe, China and Australia. It also covers key countries (regions), viz, U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, UAE, etc. The report includes country-wise and region-wise market size for the period 2015-2026. It also includes market size and forecast by each end users segment in terms of revenue for the period 2015-2026. Competition Analysis In the competitive analysis section of the report, leading as well as prominent players of the global Adrenomyeloneuropathy Treatment market are broadly studied on the basis of key factors. The report offers comprehensive analysis and accurate statistics on revenue by the player for the period 2015-2020. It also offers detailed analysis supported by reliable statistics on price and revenue (global level) by player for the period 2015-2020. On the whole, the report proves to be an effective tool that players can use to gain a competitive edge over their competitors and ensure lasting success in the global Adrenomyeloneuropathy Treatment market. All of the findings, data, and information provided in the report are validated and revalidated with the help of trustworthy sources. The analysts who have authored the report took a unique and industry-best research and analysis approach for an in-depth study of the global Adrenomyeloneuropathy Treatment market. The following players are covered in this report:, Ascend Biopharmaceuticals, Novadip Biosciences, Eureka Therapeutics, Human Longevity, Regeneus, Allogene Therapeutics, BioRestorative Therapies, Immatics Biotechnologies, NewLink Genetics, Cytori Therapeutics, Talaris Therapeutics Adrenomyeloneuropathy Treatment Breakdown Data by Therapy, Steroid Replacement Therapy, Stem Cell Transplant Adrenomyeloneuropathy Treatment Breakdown Data by End Users, Hospitals, Clinics, Ambulatory Surgical Centers, Others

In terms of region, this research report covers almost all the major regions across the globe such as North America, Europe, South America, the Middle East, and Africa, and the Asia Pacific. Europe and North America regions are anticipated to show an upward growth in the years to come. While Adrenomyeloneuropathy Treatment market in Asia Pacific regions is likely to show remarkable growth during the forecasted period. Cutting edge technology and innovations are the most important traits of the North America region and thats the reason most of the time the US dominates the global markets. The keyword market in the South, America region is also expected to grow in the near future.

Competitive Landscape

It is important for every market participant to be familiar with the competitive scenario in the global Adrenomyeloneuropathy Treatment industry. In order to fulfil the requirements, the industry analysts have evaluated the strategic activities of the competitors to help the key players strengthen their foothold in the market and increase their competitiveness.

Key companies operating in the global Adrenomyeloneuropathy Treatment market include: Ascend Biopharmaceuticals, Novadip Biosciences, Eureka Therapeutics, Human Longevity, Regeneus, Allogene Therapeutics, BioRestorative Therapies, Immatics Biotechnologies, NewLink Genetics, Cytori Therapeutics, Talaris Therapeutics Adrenomyeloneuropathy Treatment

Key questions answered in the report:

What is the growth potential of the Adrenomyeloneuropathy Treatment market?

Which product segment will grab a lions share?

Which regional market will emerge as a frontrunner in the coming years?

Which application segment will grow at a robust rate?

What are the growth opportunities that may emerge in the Adrenomyeloneuropathy Treatment industry in the years to come?

What are the key challenges that the global Adrenomyeloneuropathy Treatment market may face in the future?

Which are the leading companies in the global Adrenomyeloneuropathy Treatment market?

Which are the key trends positively impacting the market growth?

Which are the growth strategies considered by the players to sustain hold in the global Adrenomyeloneuropathy Treatment market

Reasons to buy this report:

QY Research report is designed in a method that assists clients to acquire a complete knowledge of the overall market scenario and the important sectors.

This report consists of a detailed overview of market dynamics and comprehensive research.

Explore further market opportunities and identify high potential categories based on detailed volume and value analysis

Detail information on competitive landscape, recent market trends and changing technologies that can be useful for the companies which are competing in this market

Gaining knowledge about competitive landscape based on detailed brand share analysis to plan an effective market positioning

Enquire Customization in the Report

https://www.qyresearch.com/customize-request/form/1654351/global-adrenomyeloneuropathy-treatment-market

Finally, the global Adrenomyeloneuropathy Treatment Market is a valuable source of guidance for individuals and companies. One of the major reasons behind providing market attractiveness index is to help the target audience and clients to identify the several market opportunities in the global Adrenomyeloneuropathy Treatment market. Moreover, for a better understanding of the market, QY Research has also presented a key to get information about various segments of the global Adrenomyeloneuropathy Treatment market.

Table of content

1 Report Overview1.1 Study Scope1.2 Key Market Segments1.3 Players Covered: Ranking by Adrenomyeloneuropathy Treatment Revenue1.4 Market Analysis by Therapy1.4.1 Global Adrenomyeloneuropathy Treatment Market Size Growth Rate by Therapy: 2020 VS 20261.4.2 Steroid Replacement Therapy1.4.3 Stem Cell Transplant1.5 Market by End Users1.5.1 Global Adrenomyeloneuropathy Treatment Market Share by End Users: 2020 VS 20261.5.2 Hospitals1.5.3 Clinics1.5.4 Ambulatory Surgical Centers1.5.5 Others1.6 Coronavirus Disease 2019 (Covid-19): Adrenomyeloneuropathy Treatment Industry Impact1.6.1 How the Covid-19 is Affecting the Adrenomyeloneuropathy Treatment Industry1.6.1.1 Adrenomyeloneuropathy Treatment Business Impact Assessment Covid-191.6.1.2 Supply Chain Challenges1.6.1.3 COVID-19s Impact On Crude Oil and Refined Products1.6.2 Market Trends and Adrenomyeloneuropathy Treatment Potential Opportunities in the COVID-19 Landscape1.6.3 Measures / Proposal against Covid-191.6.3.1 Government Measures to Combat Covid-19 Impact1.6.3.2 Proposal for Adrenomyeloneuropathy Treatment Players to Combat Covid-19 Impact 1.7 Study Objectives 1.8 Years Considered 2 Global Growth Trends by Regions2.1 Adrenomyeloneuropathy Treatment Market Perspective (2015-2026)2.2 Adrenomyeloneuropathy Treatment Growth Trends by Regions2.2.1 Adrenomyeloneuropathy Treatment Market Size by Regions: 2015 VS 2020 VS 20262.2.2 Adrenomyeloneuropathy Treatment Historic Market Share by Regions (2015-2020)2.2.3 Adrenomyeloneuropathy Treatment Forecasted Market Size by Regions (2021-2026) 2.3 Industry Trends and Growth Strategy 2.3.1 Market Top Trends 2.3.2 Market Drivers2.3.3 Market Challenges2.3.4 Porters Five Forces Analysis2.3.5 Adrenomyeloneuropathy Treatment Market Growth Strategy2.3.6 Primary Interviews with Key Adrenomyeloneuropathy Treatment Players (Opinion Leaders) 3 Competition Landscape by Key Players3.1 Global Top Adrenomyeloneuropathy Treatment Players by Market Size3.1.1 Global Top Adrenomyeloneuropathy Treatment Players by Revenue (2015-2020)3.1.2 Global Adrenomyeloneuropathy Treatment Revenue Market Share by Players (2015-2020)3.1.3 Global Adrenomyeloneuropathy Treatment Market Share by Company Type (Tier 1, Tier 2 and Tier 3)3.2 Global Adrenomyeloneuropathy Treatment Market Concentration Ratio3.2.1 Global Adrenomyeloneuropathy Treatment Market Concentration Ratio (CR5 and HHI)3.2.2 Global Top 10 and Top 5 Companies by Adrenomyeloneuropathy Treatment Revenue in 20193.3 Adrenomyeloneuropathy Treatment Key Players Head office and Area Served3.4 Key Players Adrenomyeloneuropathy Treatment Product Solution and Service3.5 Date of Enter into Adrenomyeloneuropathy Treatment Market3.6 Mergers & Acquisitions, Expansion Plans 4 Breakdown Data by Therapy (2015-2026)4.1 Global Adrenomyeloneuropathy Treatment Historic Market Size by Therapy (2015-2020)4.2 Global Adrenomyeloneuropathy Treatment Forecasted Market Size by Therapy (2021-2026) 5 Adrenomyeloneuropathy Treatment Breakdown Data by End Users (2015-2026)5.1 Global Adrenomyeloneuropathy Treatment Market Size by End Users (2015-2020)5.2 Global Adrenomyeloneuropathy Treatment Forecasted Market Size by End Users (2021-2026) 6 North America6.1 North America Adrenomyeloneuropathy Treatment Market Size (2015-2020)6.2 Adrenomyeloneuropathy Treatment Key Players in North America (2019-2020)6.3 North America Adrenomyeloneuropathy Treatment Market Size by Therapy (2015-2020)6.4 North America Adrenomyeloneuropathy Treatment Market Size by End Users (2015-2020) 7 Europe7.1 Europe Adrenomyeloneuropathy Treatment Market Size (2015-2020)7.2 Adrenomyeloneuropathy Treatment Key Players in Europe (2019-2020)7.3 Europe Adrenomyeloneuropathy Treatment Market Size by Therapy (2015-2020)7.4 Europe Adrenomyeloneuropathy Treatment Market Size by End Users (2015-2020) 8 China8.1 China Adrenomyeloneuropathy Treatment Market Size (2015-2020)8.2 Adrenomyeloneuropathy Treatment Key Players in China (2019-2020)8.3 China Adrenomyeloneuropathy Treatment Market Size by Therapy (2015-2020)8.4 China Adrenomyeloneuropathy Treatment Market Size by End Users (2015-2020) 9 Australia9.1 Australia Adrenomyeloneuropathy Treatment Market Size (2015-2020)9.2 Adrenomyeloneuropathy Treatment Key Players in Australia (2019-2020)9.3 Australia Adrenomyeloneuropathy Treatment Market Size by Therapy (2015-2020)9.4 Australia Adrenomyeloneuropathy Treatment Market Size by End Users (2015-2020) 10Key Players Profiles10.1 Ascend Biopharmaceuticals10.1.1 Ascend Biopharmaceuticals Company Details10.1.2 Ascend Biopharmaceuticals Business Overview and Its Total Revenue10.1.3 Ascend Biopharmaceuticals Adrenomyeloneuropathy Treatment Introduction10.1.4 Ascend Biopharmaceuticals Revenue in Adrenomyeloneuropathy Treatment Business (2015-2020))10.1.5 Ascend Biopharmaceuticals Recent Development10.2 Novadip Biosciences10.2.1 Novadip Biosciences Company Details10.2.2 Novadip Biosciences Business Overview and Its Total Revenue10.2.3 Novadip Biosciences Adrenomyeloneuropathy Treatment Introduction10.2.4 Novadip Biosciences Revenue in Adrenomyeloneuropathy Treatment Business (2015-2020)10.2.5 Novadip Biosciences Recent Development10.3 Eureka Therapeutics10.3.1 Eureka Therapeutics Company Details10.3.2 Eureka Therapeutics Business Overview and Its Total Revenue10.3.3 Eureka Therapeutics Adrenomyeloneuropathy Treatment Introduction10.3.4 Eureka Therapeutics Revenue in Adrenomyeloneuropathy Treatment Business (2015-2020)10.3.5 Eureka Therapeutics Recent Development10.4 Human Longevity10.4.1 Human Longevity Company Details10.4.2 Human Longevity Business Overview and Its Total Revenue10.4.3 Human Longevity Adrenomyeloneuropathy Treatment Introduction10.4.4 Human Longevity Revenue in Adrenomyeloneuropathy Treatment Business (2015-2020)10.4.5 Human Longevity Recent Development10.5 Regeneus10.5.1 Regeneus Company Details10.5.2 Regeneus Business Overview and Its Total Revenue10.5.3 Regeneus Adrenomyeloneuropathy Treatment Introduction10.5.4 Regeneus Revenue in Adrenomyeloneuropathy Treatment Business (2015-2020)10.5.5 Regeneus Recent Development10.6 Allogene Therapeutics10.6.1 Allogene Therapeutics Company Details10.6.2 Allogene Therapeutics Business Overview and Its Total Revenue10.6.3 Allogene Therapeutics Adrenomyeloneuropathy Treatment Introduction10.6.4 Allogene Therapeutics Revenue in Adrenomyeloneuropathy Treatment Business (2015-2020)10.6.5 Allogene Therapeutics Recent Development10.7 BioRestorative Therapies10.7.1 BioRestorative Therapies Company Details10.7.2 BioRestorative Therapies Business Overview and Its Total Revenue10.7.3 BioRestorative Therapies Adrenomyeloneuropathy Treatment Introduction10.7.4 BioRestorative Therapies Revenue in Adrenomyeloneuropathy Treatment Business (2015-2020)10.7.5 BioRestorative Therapies Recent Development10.8 Immatics Biotechnologies10.8.1 Immatics Biotechnologies Company Details10.8.2 Immatics Biotechnologies Business Overview and Its Total Revenue10.8.3 Immatics Biotechnologies Adrenomyeloneuropathy Treatment Introduction10.8.4 Immatics Biotechnologies Revenue in Adrenomyeloneuropathy Treatment Business (2015-2020)10.8.5 Immatics Biotechnologies Recent Development10.9 NewLink Genetics10.9.1 NewLink Genetics Company Details10.9.2 NewLink Genetics Business Overview and Its Total Revenue10.9.3 NewLink Genetics Adrenomyeloneuropathy Treatment Introduction10.9.4 NewLink Genetics Revenue in Adrenomyeloneuropathy Treatment Business (2015-2020)10.9.5 NewLink Genetics Recent Development10.10 Cytori Therapeutics10.10.1 Cytori Therapeutics Company Details10.10.2 Cytori Therapeutics Business Overview and Its Total Revenue10.10.3 Cytori Therapeutics Adrenomyeloneuropathy Treatment Introduction10.10.4 Cytori Therapeutics Revenue in Adrenomyeloneuropathy Treatment Business (2015-2020)10.10.5 Cytori Therapeutics Recent Development10.11 Talaris Therapeutics10.11.1 Talaris Therapeutics Company Details10.11.2 Talaris Therapeutics Business Overview and Its Total Revenue10.11.3 Talaris Therapeutics Adrenomyeloneuropathy Treatment Introduction10.11.4 Talaris Therapeutics Revenue in Adrenomyeloneuropathy Treatment Business (2015-2020)10.11.5 Talaris Therapeutics Recent Development 11Analysts Viewpoints/Conclusions 12Appendix12.1 Research Methodology12.1.1 Methodology/Research Approach12.1.2 Data Source12.2 Disclaimer12.3 Author Details

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Adrenomyeloneuropathy Treatment Market Growth by Top Companies, Trends by Types and Application, Forecast to 2026|Novadip Biosciences, Eureka...

AffyImmune Therapeutics presents novel CAR T development programs at the annual meeting of the American Association of Cancer Research | DNA RNA and…

DetailsCategory: DNA RNA and CellsPublished on Friday, 03 July 2020 10:25Hits: 378

NATICK, MA, USA I July2, 2020 I AffyImmune Therapeutics, Inc. disclosed novel advancements in their proprietary affinity-tuned CAR T-cell programs and technology in three presentations at the recent Annual Meeting of the American Association for Cancer Research (AACR). One presentation reported on a new CAR T design for localized and inducible cytokine release. The other two described their affinity-tuned CAR T cell design approach that maintains robust tumor cell killing while reducing toxicity. The company currently has an open IND for the treatment of relapsed or refractory thyroid cancer using an affinity-tuned CAR T-cell targeting the ICAM-1 protein, which is overexpressed in advanced thyroid cancer.

Chimeric antigen receptor (CAR)-T cell therapy has shown robust anti-cancer responses in hematologic malignancies, but applying this therapeutic approach to solid tumors has been hindered by multiple challenges, including impaired T cell infiltration of the immune-suppressive tumor environment and on-target/off-tumor cytotoxicity to normal tissues. To improve infiltration and mitigate toxicity, AffyImmune developed CARs with selective targeting and fine-tuned affinity.

Highly localized, inducible interleukin-12 release augments ICAM-1 CAR T cell activity against solid tumors

One presentation (abstract #4359) demonstrated that IL-12 secretion induced the expression of pro-inflammatory cytokines IFN- and TNF- both in vitro and in vivo, suggesting a mechanism by which local release of inducible IL-12 can help overcome hostile tumor microenvironments and augment anti-tumor immune responses. The inducible IL-12 CAR T cells exhibited much more robust elimination of subcutaneous and peritoneal tumors compared to CAR T cells lacking inducible IL-12 expression.

Mitigating on-target off-tumor cytotoxicity of EpCAM CAR-T by affinity tuning

Two additional presentations focused on the multi-cancer biomarker epithelial cell adhesion molecule (EpCAM). EpCam is frequently over-expressed in a wide variety of carcinomas, including colon, gastric, pancreas, and breast cancers. This makes EpCAM attractive for targeted therapeutics, but recent clinical trials of EpCAM-targeting therapeutics have shown significant dose-limiting toxicities resulting in limited clinical responses. To selectively target EpCAM high tumors, AffyImmune is developing affinity tuned EpCAM CAR T cells.

In one EpCAM presentation (abstract #4534), author Huan Yang of AffyImmune described the development of AffyImmune's EpCAM targeting technology, which involved a rational design approach incorporating lower-affinity single-chain antibody (scFv) variants. While high-affinity EpCAM-targeting CAR T-cells kill both normal human epithelial cells as well as EpCAM-high tumor cells, AffyImmune's lower affinity CAR T-cells were shown to spare normal human epithelial cells while still effectively killing tumor cells expressing high levels of EpCAM. Further, transcriptional profiling suggested that lower affinity CAR T variants were less prone to exhaustion.

Eradication of EpCAM expressing solid tumors by low-affinity CAR T cells

In the final, complimentary presentation (abstract #4534), it was shown that potent in vivo anti-tumor activity could be obtained using lower affinity CAR T cells in an intraperitoneal gastric cancer model, an orthotopic pancreatic tumor model, and in a PDX model using a gastric cancer patient-derived xenograft. The authors concluded that the technology enabled "eradication of various difficult-to-treat solid tumors, without triggering severe treatment-related toxicities," showing promise for the fine-tuning approach as a general strategy for identifying a therapeutic window for CAR-T cells in challenging, solid tumor types.

"Together, these presentations demonstrate the elegance and effectiveness of AffyImmune's strategy," said AffyImmune co-founder Moonsoo Jin. "We're focused on identifying the optimal affinity for targeting tumor-associated antigens using CAR T-cells. In this way, it is possible to both avoid non-tumor cells expressing basal levels of the target and to optimize CAR T-cell function, longevity, and tumor killing."

All presentations were presented at the AACR Virtual Annual Meeting II between June 22-24, 2020, and are available for on-demand viewing.

About AffyImmune Therapeutics, Inc.

AffyImmune is realizing the potential of cancer immunotherapy by extending the anti-cancer activity of CAR-T cell therapy to solid tumors, improving the safety and efficacy of CAR-T treatment. Based on Professor Moonsoo Jin's work at Weill Cornell Medicine, AffyImmune's proprietary technology allows fine-tuning of CAR-T cells affinity to selectively kill tumor cells, reducing toxicity. AffyImmune scientists have also developed a tracking system, that can be engineered into any CAR-T cell, to allow for real-time localization of cells after administration to patients.

AffyImmune's lead asset, AIC100, is an affinity-tuned, 3rd generation CAR-T cell therapy co-expressing SSTR2. Preclinical studies in various solid tumor models demonstrated AIC100's robust and enduring tumor eradication and superior safety profile compared to standard, high-affinity CAR T cell therapy. In 2019, AffyImmune received Orphan Drug Designation by the FDA for AIC100 and began recruitment for a Phase 1 trial to treat advanced thyroid cancer.

Founded in 2016, AffyImmune is headquartered in Natick, MA, and is incubated by ORI Capital.

About ORI Healthcare Fund L.P.

ORI Healthcare Fund is a $200 million venture capital fund focused on investing in innovative companies with disruptive technologies in the healthcare industry globally. The General Partner of the Fund was founded by Ms. Simone (Hong Fang) Song, the former head of China Healthcare Investment Banking at Goldman Sachs.

SOURCE: AffyImmune Therapeutics

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AffyImmune Therapeutics presents novel CAR T development programs at the annual meeting of the American Association of Cancer Research | DNA RNA and...

Genomic Biomarker Market Size, Share, Application Analysis, Regional Outlook, Growth Trends, Key Players, Competitive Strategies and Forecasts to 2025…

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Ponce De Leon Health Announces Results Of Pilot Research Suggesting That Biological Age Can Be Reduced In Humans – PRNewswire

FERNANDINA BEACH, Fla., June 29, 2020 /PRNewswire/ --Ponce De Leon Health, Inc. ("Ponce de Leon"), a longevity company focused on reversing epigenetic aging, today announced the results of pilot research suggesting that Rejuvant LifeTabs, reduced the biological age of customers by an average of 8.5 years. The biological age was assessed by way of a DNA biomarker test that measures DNA methylation. Of the subjects in the analysis, two-thirds showed a statistically significant reduction in biological age. The analysis was based on data from subjects who had taken Rejuvant LifeTabs for a period of four to six months. Rejuvant, a dietary supplement, is Ponce de Leon's first commercial product.

The data were independently compiled by Dr. Yelena Budovskaya, Ph.D., co-founder and lead scientist of TruMe Labs, a pioneer in the emerging field of epigenetic aging testing. Ponce de Leon is a distributor of TruMe's TruAge Index, a take-at-home, non-invasive epigenetic age test. The subjects included in the analysis represent all 17 customers who had taken a TruAge test at the time of their first purchase of Rejuvant, as well as a second test after taking the supplement for four to six months. The TruAge Index measures DNA methylation, which is growing in acceptance by longevity researchers as an important biomarker of biological aging.

All formulations of LifeTabs contain the proprietary active ingredient LifeAKG,which was shown in recent pre-clinical animal studies to increase lifespan (the length of life) and healthspan (the length of healthy life) in mammalian models. Ponce de Leon has eight patents pending for inventions arising from its research and development activities.

Ponce De Leon is currently enrolling participants for a larger, randomized, double-blind, placebo-controlled clinical trial, to be conducted at Indiana University Medical Center later this year.

The Company's Chief Medical Officer, Francis R. Palmer, M.D., stated that "although at this stage we only have consumer data, these findings are very promising. We are only aware of one other published trial where researchers were able to show a reduction in biological age in humans as measured by DNA methylation. In this other trial, modest reductions in biological age were observed in a small number of subjects who were treated with a combination of prescription drugs for a year. The Rejuvant results are suggestive at this time but it showed a greater average reduction in biological age, achieved in six months, using non-prescription compounds." Added Palmer, "we expect our human clinical trial results to corroborate the encouraging data we have now, and we believe this will have a meaningful impact on both the scientific and consumer communities."

The Company's CEO and Founder, Tom Weldon, commented "the pilot research data appears to be consistent with our earlier mammal results but we appreciate the need for a more robust study to validate this data on lifespan and healthspan research. We look forward to conducting that study later this year and adding to these positive findings. The potential for Rejuvant to reverse epigenetic aging, as measured by DNA methylation testing and other measurable biological markers, may profoundly benefit not only the individuals who take the product, but also the economies and societies in which they participate and live."

Please see http://www.Rejuvant.com for more information on the groundbreaking science in LifeTabs.

About Ponce De Leon HealthPonce De Leon Health (www.PDLHealth.com) is a commercial-stage company focused on reversing epigenetic aging. Their work focuses on novel use of a combination of commonly used food ingredients developed independently by the world's leading non-profit institute studying aging. Their goal is to increase human healthspan, improve quality of life, and reduce the cost of providing late stage health care to customers. Their inaugural product, Rejuvant LifeTabs, is available at http://www.Rejuvant.com. You can also learn more about Rejuvant on Facebook, Twitter, and YouTube.

SOURCE Ponce De Leon Health

http://pdlhealth.com/

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Ponce De Leon Health Announces Results Of Pilot Research Suggesting That Biological Age Can Be Reduced In Humans - PRNewswire

Air pollution is much worse than we thought. Climate change is far from the only problem with fossil fuels. – Vox.com

In the late 1960s, the US saw regular, choking smog descend over New York City and Los Angeles, 100,000 barrels of oil spilled off the coast of Santa Barbara, California, and, perhaps most famously, fires burning on the surface of the Cuyahoga River in Ohio. These grim images sparked the modern environmental movement, the first Earth Day, and a decade of extraordinary environmental lawmaking and rulemaking (much of it under a Republican president, Richard Nixon).

From the 70s through the beginning of the 21st century, the fight against fossil fuels was a fight about pollution, especially air pollution.

In the ensuing decades, the focus has shifted to global warming, and fossil fuels have largely been reframed as a climate problem. And that makes sense, given the enormous implications of climate change for long-term human well-being.

But theres an irony involved: The air pollution case against fossil fuels is still the best case!

In fact, even as attention has shifted to climate change, the air pollution case has grown stronger and stronger, as the science on air pollution has advanced by leaps and bounds. Researchers are now much more able to pinpoint air pollutions direct and indirect effects, and the news has been uniformly bad.

The evidence is now clear enough that it can be stated unequivocally: It would be worth freeing ourselves from fossil fuels even if global warming didnt exist. Especially now that clean energy has gotten so cheap, the air quality benefits alone are enough to pay for the energy transition.

This conclusion has been reaffirmed by the latest air quality research, presented at a recent hearing of the House Committee on Oversight and Reform by Drew Shindell, Nicholas professor of earth science at Duke University (and a lead author on both recent IPCC reports).

Shindells testimony reveals that the effects of air pollution are roughly twice as bad as previously estimated. That is a bombshell in a sane world, it would be front-page news across the country.

The air quality scientific community has hypothesized this for at least a decade, but research advances have let us quantify and confirm this notion, over and over, says Rebecca Saari, an air quality expert who teaches in civil and environmental engineering at the University of Waterloo. The air quality co-benefits are generally so valuable that they exceed the cost of climate action, often many times over.

Lets take a closer look at the evidence for this extraordinary claim, and then well consider its political implications.

Recently, I wrote about an ambitious and detailed new plan to substantially decarbonize the US economy by 2035 (primarily through electrification) and said that it would bring transformative social and health benefits.

Shindell and his team at Duke have attempted to quantify those benefits, drawing on the latest science. They began with the climate model used by NASAs Goddard Institute and upgraded it to represent air pollution at relatively high resolution, Shindell testified, making this model suitable for simultaneously studying the impact of climate and air quality.

Using this all-in-one model, Shindells team mapped out a pathway from 2020 to 2070 that reduced US greenhouse gas emissions consistent with the worlds pledge to stay below 2C and attempted to quantify the air quality and climate benefits.

(Note: Though the model and the techniques have been peer-reviewed, Shindells crunching of the latest numbers is currently going through peer review. He includes extensive documentation of his methodology in an appendix to his testimony.)

The numbers are eye-popping. Shindell testified: Over the next 50 years, keeping to the 2C pathway would prevent roughly 4.5 million premature deaths, about 3.5 million hospitalizations and emergency room visits, and approximately 300 million lost workdays in the US.

All that prevented death, illness, and lost productivity adds up to a lot of savings:

The avoided deaths are valued at more than $37 trillion. The avoided health care spending due to reduced hospitalizations and emergency room visits exceeds $37 billion, and the increased labor productivity is valued at more than $75 billion. On average, this amounts to over $700 billion per year in benefits to the US from improved health and labor alone, far more than the cost of the energy transition.

Importantly, many of the benefits can be accessed in the near term. Right now, air pollution leads to almost 250,000 premature deaths a year in the US. Within a decade, aggressive decarbonization could reduce that toll by 40 percent; over 20 years, it could save around 1.4 million American lives that would otherwise be lost to air quality.

Of the potential yearly deaths prevented, Rep. Robin Kelly of Illinois remarked at the hearing, Thats a huge number. Thats nearly three times the number of lives we lose in car accidents every year. Its twice the number of deaths caused by opioids in the past few years. And its even more than the number of Americans we lose to diabetes each year.

If the numbers are shocking, its because the science has been developing rapidly. First, says Shindell, theres been a huge upsurge in work in developing countries, in particular China, which has produced larger data sets and a wider, fuller picture of the real-world effects of exposure.

Second, where scientists used to focus almost exclusively on pollution effects for which there is an established and well-understood biological pathway, the recent production of enormous data sets (for instance, the entire population of more than 60 million Medicare patients) has allowed them to uncover new statistical correlations.

With giant data sets, you can control for socioeconomic status, temperature, hypertension and other existing conditions, and other variables, says Shindell. You can convincingly demonstrate that correlation is in fact causal, because you can rule out essentially every other possibility.

For example, scientists now know that exposure to smog (tiny, microscopic particulates) hurts prenatal and young brains. Even though they dont yet fully understand the biological mechanism, they know it reduces impulse control and degrades academic performance. Similarly, they know it hurts the kidneys, the spleen, even the nervous system.

The well-understood pathways, things like strokes, lower respiratory infections, and chronic obstructive pulmonary disease, only seem to capture about half the total, Shindell says. When you look at the [new] studies, you find that air pollution seems to affect almost every organ in the human body.

A recent study from the national academies of multiple countries, including the US, put it this way:

The scientific evidence is unequivocal: air pollution can harm health across the entire lifespan. It causes disease, disability and death, and impairs everyones quality of life. It damages lungs, hearts, brains, skin and other organs; it increases the risk of disease and disability, affecting virtually all systems in the human body.

About twice as many people die in total as die just from the pathways we understand, says Shindell. Weve been underestimating all along.

Alongside these updated estimates of air pollution impacts, Shindells team developed a new way of assessing the nationwide health impacts of severe heat, in order to quantify one of the best-understood effects of climate change. Combining them into one model, Shindell testified, we find impacts roughly double those that would have been obtained using older evidence.

While that may sound like a big jump, it is likely a lower bound. On both air pollution and climate change, the study omitted many effects that are clearly present but cannot yet be reliably quantified. The true numbers are almost certainly higher.

The implications of this new air quality research are far-reaching. Though the benefits of the Clean Air Act were already thought to outweigh the costs, they may be twice as high as previously estimated. The costs of Trumps rollbacks of Obamas fuel economy standards and Clean Power Plan are up to twice as large as previously estimated.

It is no coincidence that Trumps Environmental Protection Agency is trying to exclude consideration of co-benefits (often the largest class of benefits) in its air quality rulemakings. Its no coincidence that it is trying to exclude consideration of studies with anonymous participants, a category that encompasses all the latest research Shindell and others draw on. The fossil fuel lobby, which now includes the entire executive branch, has long understood that the science isnt going its way. These rule changes are its last-ditch bid to blind the government to new research.

Climate change has often been framed as an intractable problem for international coordination, a matter of shared sacrifice, with every country incentivized to be a free rider, reaping the benefits without taking on any of the costs.

But the latest air pollution research, coupled with the plunging cost of clean energy, should render that dynamic moot.

It is true that climate change can only be averted with the entire worlds cooperation; if the US reduces its emissions to net zero but the other countries of the world (especially China and India) continue on their current trajectory, it will make almost no difference in temperature. The health benefits of avoided severe heat will not manifest.

However and this is the crucial fact the air quality benefits will manifest, no matter what the rest of the world does. Shindells team ran a version of their scenario in which the US came into compliance with a 2C pathway but the rest of the world continued with current policies. We found that US action alone would bring us more than two-thirds of the health benefits of worldwide action over the next 15 years, Shindell testified, with roughly half the total over the entire 50-year period analyzed.

The air quality benefits arrive much sooner than the climate benefits. They are, at least for the next several decades, much larger. They can be secured without the cooperation of other countries. And, by generating an average of $700 billion a year in avoided health and labor costs, they will more than pay for the energy transition on their own. Climate change or no climate change, its worth ditching fossil fuels.

And if this is true in the US which, after all, has comparatively clean air it is true tenfold for countries like China and India, where air quality remains abysmal. A Lancet Commission study in 2017 found that in 2015, air pollution killed 1.81 million people in India and 1.58 million in China.

Shindells research reveals that those estimates may be woefully low. (He hopes to do similar modeling on China at some point.) The true toll may be almost double that, which is why both countries have experienced mass demonstrations against pollution in recent years that have left their governments scrambling.

Air pollution remains the leading environmental health risk factor contributing to premature death worldwide, as demonstrated repeatedly by the Global Burden of Disease studies, says Saari. Health care costs and lost worker productivity are direct economic impacts of air pollution so large they can exceed the costs of climate policy.

Shindell ended with a call to Congress, testifying that it would be unconscionable to realize these benefits could be obtained and not attempt to obtain them.

The extraordinary level of suffering humanity is currently experiencing from air pollution is not necessary for modernity; it could be reduced, at a cost well below the net social benefits, with clean energy technologies on hand.

If they are not necessary, then the millions of lives ended or degraded by fossil fuels every year are a choice. And when suffering on this scale, that is this brutally inequitable, becomes a choice, it enters the same ethical terrain as war, slavery, and genocide. The effects are more distributed over time and geography, as are the decision-making and the moral culpability, but the cumulative impact on human well-being on our longevity, health, learning, and happiness is comparable, and every bit as much worth fighting.

US policymakers have a chance to kick-start an energy transition that could save 1.4 million American lives over the next 20 years, especially among the most vulnerable, even as it creates jobs and saves consumers money. As Shindell says, it would be unconscionable not to act on it.

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Air pollution is much worse than we thought. Climate change is far from the only problem with fossil fuels. - Vox.com

The resiliency of white-tailed deer – – Adirondack Almanack

Editors note: This is part two of a two-part series.

Deer appear in paleolithic cave paintings at Altamira, on the north coast of Spain, going back 36,000 years.

The white tailed deer has been in North America for about 4 million years, making the white tail one of the real veterans of nearly all varying habitats in North America, ranging from Nova Scotia west to southern Alberta, sweeping south into Central America, with gaps west of the Rockies.

To put that in perspective, modern moose have only been in North America about 15,000 years, having migrated through Berengia about the same time the ancestors of native Americans began to trickle across.

In North America, moose have much more serious problems with winter ticks in affected habitats than deer have. For example, deer go through winter with an average of about 300 winter ticks, while moose may accumulate from 10,000 to 90,000 winter ticks, a condition which is probably a serious factor in why moose are in trouble all along the US-Canadian border from Maine to Minnesota. Winter ticks are beginning to show up in New York as well. Are white tails simply more efficient groomers, or could there be a connection related to longevity in habitat, and the ability of animals to adapt to parasites and challenges not found in previous habitats?

Deer on the food chain

Deer have played a major role in human nutrition and survival for a very long time. European immigrants to America, learned from native Americans about utilizing all parts of the white tail. Deer numbers rose and fell in the 19th century with market hunting by both native Americans and the growing numbers of settlers and immigrants, joining individual hunting, along with deforestation and destruction of deer habitat. State regulation of hunting slowed down the hunting free-for-all, and helped increase deer numbers, but two other factors in the first decades of the 20th century led to an explosion of deer.

Everything in nature is connected. The increasing suburbanization and the expansion of farming in America had the effect of moving more people into deer habitat, while introducing deer to our orchards, crops and gardens, thereby increasing their ability to making a living and reproduce. The more deer saw, heard and smelled human activity, without being shot at, the more it helped to inure them to the dangers of our presence.

In an environment without humans, gray wolves tend to be the number one controller of both deer and western coyotes, the latter in competition for safer prey, smaller than moose, elk and bison, but the accelerating persecution of gray wolves, which included poisoning campaigns and bounties led to an explosion of both deer and coyotes. Predators tend to strengthen the health of prey populations by detecting and eliminating disease and weakness. An unfortunate example of why we shouldnt eliminate predators is the reappearance of chronic wasting disease, an infectious disease in deer which is slowly spreading in areas where wolves had historically kept it in check.

As wolf habitat in the lower 48 dwindled to Minnesota, the only state which kept the Federal wolfers out, western coyote numbers exploded out west, leading to a manifest destiny in reverse, with coyotes increasingly moving east under and over the Great Lakes, exploiting available wolf habitat in the lower 48, and causing further hybridization of Algonquin wolves in Ontario and Quebec, already averaging 20% western coyote going back tens of thousands of years, long before there were any humans in North America.

Yes, you read that correctly. Wolves have the most dangerous job in nature for two reasons. An alpha female may deliver 4 to 7 pups every Spring. While it is much safer for wolves to go after deer, snowshoe hare and beaver, pressure to produce food compels wolves to go after much larger, more dangerous prey, such as moose, elk and bison. Moose, for example, are so dangerous in defending themselves, that wolves test 20 moose for each one they decide to take a chance and attack. As though that factor in intself didnt make a wolfs life dangerous enough, in wolf economics, the pack has to defend a territory large enough to contain enough prey for the pack to make a living, and if a neighboring packs territory is not producing, theyll be invading another packs territory, which will result in wolves killing each other over access to prey. Add these factors to our inclination to shoot and trap wolves, and wolves are lucky to reach their fifth birthday in the wild.

Gray wolves tend to kill coyotes, just as coyotes kill fox, routinely and opportunistically eliminating the smaller predator, as a means of creating a larger base of smaller, safer prey, but starting in Minnesota and heading east over Lake Superior, young male wolves, who disperse from, in other words, leave Mom and Dads territory, to seek an unguarded territory, or a territory they may be able to take over, may discover that female wolves dont generally disperse as far as males, so they may end up defending a territory no other wolf wants, and they may end up mating with a female coyote.

Deer hunters tend to bemoan the impact of eastern coydogs, more accurately termed coywolves, because of their hybridization with Algonquin wolves, on the deer population in the Northeast. But the coyote impact on deer numbers is much greater on fawns than it is on adults, partly thanks to our assistance with traffic accidents supplying deer as roadkill. A study by SUNY College of Environmental Science & Forestry a few years back concluded that, excluding fawns, 92% of deer eaten by coyotes in New York were killed by cars. About 60% of fawns reach maturity, while 80% of fawn mortality is caused by predators, including bears, wolves, coyotes, cougars, bobcats, lynx, fishers, eagles, and even foxes. Other fawn mortality factors range from car accidents to getting caught in fencing or under farm equipment, or natural causes like starvation and drowning.

More recently, hunting generally, and deer hunting in particular, which peaked among baby boomers in 1982, while rising in some states, and falling in others, is in a fairly steady decline nationwide. Weve lost 10% of all hunters in the last ten years, with less than 4% of Americans involved in hunting today, at exactly a time when, having largely eliminated wolves, natures tool for deer control, we need more human hunters to control deer numbers. For those concerned about health and red meat, venison is much leaner than beef, and probably half the calories.

Controlling deer without natural predators is no easy problem. Highest deer densities are often found in thickly settled suburban areas, where it is unsafe, and often illegal, to fire rifles within 500 feet of a dwelling, or shoot arrows, and the deer take a heavy toll on gardens and landscaping generally. Some towns and villages are experimenting with immunocontraception, to cut down the number of does breeding. Such methods may require multiple doses, and may only be good for a couple of years. Other towns employ specially vetted deer hunters to control local deer populations. Habitat carrying capacities, which increase as deer learn how to eat more human planted and invasive vegetation, determine how many deer a particular area can support, which means as you eliminate deer, other deer come in from surrounding areas.

This is a lesson we seem to refuse to understand. As we eliminate animals from habitat, for example beavers, they are replaced by other beavers who are attracted to the habitat for the same reason the removed beavers were. Its good beaver habitat. The same thing happens with deer, but because deer eat a much wider range of vegetation, and learn to eat our gardens, as well as invasive plants, they expand the areas they can make a living in. We always treat the symptom, rather than the cause, and end up throwing natures balance further out of whack.

In New York State, we have just under a million deer, with 60 to 70 thousand in the Adirondacks, and about 70,000 vehicle deer collisions statewide annually. Hunters took about 225,000 deer in New York State in 2018. As elegant and visually appealing as white tails are, their lives tend to be violent and short, with the average age of death for deer being about 3 years old. As a sign of the times, the mosquito, which for 80 years was the most likely animal to be involved in human mortality in the lower 48 states, just as it is in most moderately temperate countries, was knocked out of first place by the white tailed deer, because of the number of people killed in accidents involving deer.

Photos by Joe Kostoss, Eye in the Park, courtesy of the Adirondack Wildlife Refuge

Steve and Wendy Hall run the Adirondack Wildlife Refuge and Rehab Center in Wilmington. They've been rehabbing and releasing wild animals for over 45 years, specialize in predators, keep wolves as the cornerstone of their educational program, and have lived in the Adirondacks for the past 20 years. The Adirondack Wildlife Refuge became a non-profit about 10 years ago.

Visit http://www.AdirondackWildlife.org to learn more.

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The resiliency of white-tailed deer - - Adirondack Almanack

Dangers of ‘over bathing’ shared | Local Columnists | union-bulletin.com – Walla Walla Union-Bulletin

Part 1

From the Washington Statesman, June 7, 1862, Walla Walla, Washington Territory:

Over Bathing If a fish is deprived of its scales, it will be chilled to death; and reasoning analogically, and knowing, too, that the human skin scales are destroyed by the alkali of the soap, a man may wash himself too much may actually wash away the scales of his body, leaving the pores so unprotected against heat and cold and obstructions, that death will inevitably ensue; indeed, physiological research proves that if a third of the skin is removed from the body by scalding or otherwise, a fatal termination is unavoidable.

Observant persons know how soon the skin becomes pale, shriveled and tender, even on the harder hands, if kept a great deal in cold water. These are suggestive considerations for those who believe that continued water sloshings are indispensable to health and longevity Halls Journal of Health.

From the Washington Statesman, June 14, 1862, Walla Walla, Washington Territory:

Stabbing A man named Purdy was killed by a Spaniard in this county, on Wednesday last. They got into a dispute about a blanket, during the Spaniard drew Purdys knife from his belt and stabbed him to the heart. The Spaniard escaped.

From the Washington Statesman, June 21, 1862, Walla Walla, Washington Territory:

Early Vegetables No country that we have even been in is better adapted to the growth of vegetables than the Walla Walla valley. The snow had scarcely left the foothills in the spring when lettuce, radishes, onions and rutabagas were abundant in market.

New potatoes have been in market more than a week. This beats the lower country by at least two weeks. The Oregonians are in the habit of shipping their early vegetables from California. Henceforth we would recommend them to ship their supplies in this line from this valley.

Susan Pickett was professor of music at Whitman College from 19812018. She is the author of Marion and Emilie Frances Bauer: from the Wild West to American Musical Modernism a biography about two women born in Walla Walla whose careers in the New York City music scene spanned 18961955.

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Dangers of 'over bathing' shared | Local Columnists | union-bulletin.com - Walla Walla Union-Bulletin

Five organizations in southern Ariz. continuing to pursue bold environmental projects amid the pandemic – Arizona Daily Wildcat

Recently, environmental organizations have had to slow down much of their efforts to promote the safety of staff and an awareness of other pressing societal issues. Some believe that this is even resulting in opportunities for the government to sneak in and break apart environmental regulations, without the defense systems of environmental organizations.

The New York Times recently reported the Trump administration is in the process of rolling back on 34 environmental provisions, such as the National Environmental Policy Act and multiple Obama-era rules.

With COVID-19 and also the protests, people arent necessarily as focused on environmental issues that are happening right now, explained Harold Thomas, the associate director of the Watershed Management Group in Tucson. So, it's an easy time for government to roll back a lot of legislation.

Still, environmental initiatives held by a diverse range of organizations in southern Arizona are proving resilience during these difficult times. Five companies, Patagonia Area Resource Alliance, Sky Island Alliance, the Sonoran Institute, Zero-Mass Water and Local First AZ are showing that environmentalists can feel some optimism despite the whirlwinds hitting American society and the environment.

In Patagonia, the environmental watchdog organization Patagonia Area Resource Alliance has a history of keeping an eye on industrial mining in the area. For years, PARA has taken steps to hold industrial mining companies to the highest environmental standards, and this has not halted in times of the pandemic.

During the pandemic, PARA staff are continuing to monitor mining activities in a variety of ways, according to Anna Sofia, the communications and outreach coordinator. Since 2012, PARA has been tracking animals in the Patagonia Mountains with cameras to see what effects industrial mining is having on the wildlife and ecosystems. Sofia and another staff member have been continuously going out into the mountains to check these cameras.

Carolyn Shafer, PARAs mission coordinator, explained the importance of wildlife protection and monitoring in the area. She said that poor industrial mining practices could be very harmful to the wildlife and that it is a human responsibility to ensure protection.

An important thing that we need to do as humans is to assure the longevity of all species, said Shafer. The Patagonia Mountains are part of a region that has been identified by scientists as one of the top areas in the world, most in need of protection and study for species survival.

Similar to PARAs own wildlife tracking project in the Patagonia Mountains, the organization is also partnering with the Sky Island Alliance and the Mexican organization Naturalia Sonora to track wildlife along the border of Mexico. This project is meant to study the biodiversity in the region of border-wall expansion.

The organization has also been monitoring effects on the regions waterways. For example, they recently found what seems to be a leaking mine site left from historical industrial mining. Sofia describes that they have found acid mine-drainage that is flowing across a road in a canyon in the area. PARA is trying to monitor what impacts this may have on the water and reporting on it to the U.S. Forest Service.

We are actively out in nature keeping an eye on things, which has been really good, and we have still been able to do that throughout the pandemic, Sofia said.

In light of pandemic safety precautions, Sofia said that PARA is also hoping to create a multi-platform online educational program to engage the public on the risks and realities of industrialized mining. They are looking to fund much of this program with a recent grant received from Western Mining Action Network.

PARAs primary focus acting as a watchdog against poor industrial mining practices may be more important now than ever. Shafer explained that from the mid-1800s to around 1960, a total of 250,000 tons of ore was extracted from the Patagonia Mountains. Just one of the companies looking to mine now looks to remove about the same amount of ore from the mountains every 10 days.

Shafer and Sofia identified some of the major dangers that PARA looks to hold mining companies accountable for. One risk of poor mining practices is the fracturing and scarring of mountains, which would allow water from the Sonoita Creek Watershed to be diverted into those areas. Then, as the water picks up residue from mining and extracted metals, water sources important for humans and wildlife can become highly contaminated.

Additionally, Sofia noted that another worry is noise and light pollution from exploratory and underground drilling. These unnatural sounds and sights can negatively impact species in the area. For example, it can put burdens on threatened species of birds such as Mexican spotted owls and affect migration patterns, scattering populations and creating an inability to reproduce.

With everything going on in the world from environmental pressures like poor industrialized mining practices to the pandemic, Shafer stresses that PARA and the Patagonia community are staying resilient.

I have lived in this community for more than 20 years, and given the chaos of the times, there is no place nor any other group of people that I want to be with as we move through these multiple crises, Shafer said. This community has every skill set needed to co-create a thriving and resilient community and we are determined to do so.

The primary actor in the aforementioned Border Wildlife Study initiative that PARA is participating in was launched by Sky Island Alliance. Sky Island Alliance is a nonprofit in Tucson focused on protecting precious water resources, wildlife and creating awareness around the Sky Island natural region.

According to Emily Burns, the program director for Sky Island Alliance, the Border Wildlife Study was created in early March to document the wildlife community in the foothills of the Patagonia Mountains, the Huachuca Mountains and the San Rafael Valley. To do so, the organization and its project partners PARA and Naturalia Sonora have placed heat-activated and motion-activated cameras in the areas. Burns explained that these cameras are carefully arranged in a way that they can track both migrating species like black bears and mountain lions, and also the local diversity of animals.

The Sky Island Alliance formed this project in response to the Trump administrations border wall and its potential impacts on biodiversity. Burns explained that the federal government is furthering Trumps border wall project, and new waivers have been issued, allowing the construction to proceed without any environmental review.

We felt it was imperative to step in and collect information about what animals are actually here in the path of the coming border wall so that we can share that information with the public and go forward with eyes-wide-open about potential impacts to species that we care about, said Burns.

Though no border wall has been constructed yet in the region, Burns notes that past border wall studies have shown negative impacts on various species. She said that even flying species have been shown to be negatively affected, such as the once-endangered ferruginous pygmy owl.

Some of the negative effects described by Burns that could be the result of continued border wall construction include the division of natural habitats, an inability for migratory species to move and habitat fragmentation.

Burns said that in the short term, Sky Island Alliance hopes that this data can inspire people to stand up against border wall construction. In the long term, they hope that it will be baseline data that can help the public, voters and decision-makers be aware of the wildlife in the region.

Another Tucson-based organization that has been quite active in environmental initiatives and projects in the recent past is the Sonoran Institute. According to the institutes Senior Director of Programs, John Shepard, it is a community-based organization focused on connecting communities to the natural resources that nourish and sustain them.

Recently, the Sonoran Institute has been active in three major projects. These projects include the restoration of the Laguna Grande, upcoming Growing Water Smart workshops and the Living River Reports.

Since 2006, the institute has been partnering with U.S. and Mexican environmental organizations to restore Laguna Grande, a site on the Colorado River in Mexico. According to Shepard, it is the largest restoration site in the Colorado River delta.

The Sonoran Institute was inspired to restore the flow of water through the site, the natural habitat for riparian species and the groundwater for nearby impoverished areas. These are all factors that have been damaged by the Colorado River degradation.

Over many decades as Colorado River water has been dammed and diverted, the connection between the river and the sea was lost, and over 90% of the original delta was lost as well, Shepard said.

The second initiative, Growing Water Smart, is a training program for cities, towns and counties focusing on water efficiency as the Colorado River and Lake Mead lose the capacity to provide for people. Shepard said that the Sonoran Institute has trained around 30 communities so far. Much of this training is targeted toward community water leaders and public utilities.

It tries to get the people who are responsible for water supply, which tend to be your utilities, to talk and plan in coordination with people who are making decisions that will affect water demand in the future, Shepard said.

The third major project that is being pursued by the Sonoran Institute is the continued production of Living River Reports. These are annual reports documenting the condition of the Santa Cruz River.

For some time now, facilities have been restoring the flow of water in much of the Santa Cruz River by adding treated wastewater to it. The Sonoran Institutes reports aim to not only examine the health of the river as treated wastewater is deposited but also to make the case for improvements of treated wastewater quality.

Shepard said that over time, as these reports have been produced and treated wastewater quality has been upgraded, they have seen promising signs of improvement in river health. For example, they have recorded the return of the Gila topminnow, an endangered fish, to the Santa Cruz River.

Despite a series of changes that have had to be made, the Sonoran Institute and its initiatives have shown resilience during times of the COVID-19 pandemic. Thus, Shepard urges people in the environmental field to maintain a sense of optimism during this time.

Zero Mass Water, a Scottsdale based company, has been advancing the usage of hydropanels to provide safe, clean drinking water for industrial, commercial, residential and community applications. They mention how access to safe water is a human right for every community throughout the world.

Hydropanels are machines that collect water vapor from surrounding air, and then condense the vapor by increasing the humidity once it reaches the hydropanel. Panels are then arranged in such a way that it allows vapor droplets to collect and provide water. This water is then purified, ozonated and mineralized. This essentially makes the production of water an infinite and renewable source.

Zero Mass Waters initiatives look to provide the world with clean drinking water through a renewable energy source thus the Zero Mass title.

These hydropanels built by Zero Mass Water help provide water to areas across Arizona, even when various environmental challenges plague the community.

CEO of Zero Mass Water, Cody Friesen, stated that access to safe drinking water is a fundamental human right that is often too expensive, too wasteful, too extractive, and too scarce. Their hydropanels have helped to slow this problem by providing clean water to areas of Arizona that needed them the most.

With major burgeoning environmental challenges hurting Arizona such as excessive heat and water shortages, implementing a plan to obtain drinking water is important. According to the Fourth National Climate Assessment, water resources in the Southwest have already declined because of the growing population, deteriorating infrastructure and groundwater depletion, as well as human-induced climate change. Zero Mass Water is working to combat these challenges in an eco-friendly and cost-effective way.

Zero Mass Water looks to help communities not only in Arizona but across the world. With the climate changing the environmental frontier, it is uncertain to say what will happen to the main water sources that feed into major cities and rural areas.

This will be a risk for many due to the lack of availability of freshwater. Already, the United Nations indicated that 2 billion people live in countries experiencing high water stress. In response to these growing concerns, Zero Mass Water has implemented hydropanels in more than 40 other countries.

The pandemic has not slowed the companys bold efforts. Recent funding and expansion efforts with help from several organizations like BlackRock, Duke Energy and Breakthrough Energy, have allowed Zero Mass Water to further its hydropanel endeavors. According to Business Wire, they recently raised $50 million.

Phoenix-based organization focused on uplifting and empowering local businesses Local First AZ has partnered with the Tucson 2030 District, to launch a significant initiative for Tucson businesses. On May 20, Local First AZ helped to launch the Southern Arizona Green Businesses Alliance.

In recent years, Local First AZ has taken big steps to try and foster sustainable transformation in the southern Arizona economy. In 2018, the organization helped to launch Scale Up, a program for businesses to enrich sustainable actions through green workshops, networking and projects. In 2019, the organization launched the Arizona Green Business Program, a certification process aimed toward reducing environmental footprints.

Now, the introduction of the green alliance is a further step for Local First AZ. This alliance allows businesses to engage in three parts. The first part is the Green Business Leaders Program. This entry-level program provides a checklist for sustainable practices that will end with a follow-up consultation, recognition for sustainable leadership and more benefits such as marketing.

The next part is Scale Up, adopted from the original program started in 2018. This is an intermediate level program with more interactive learning opportunities.

The last part is the involvement in the Tucson 2030 District. Tucsons district is part of a collaborative effort among national districts to reduce water and energy consumption and emissions from transportation by 50% as soon as 2030.

According to Claire Kaufman, the sustainability program manager for Local First AZ, the program has been adjusted in many ways to adapt organizations to current circumstances.

COVID hit and we did a lot of adjustment on the programs to focus them even more on resiliency, so how businesses can be prepared in cases of disaster, Kaufman said.

Kaufman also described that adjustments have been made to the programs to integrate a more holistic education, including lessons on equity, social justice and environmental justice.

Its about making an economy that is environmentally resilient, economically resilient and socially resilient, Kaufman said.

A wide range of environmentally-concerned organizations are continuing to take strides toward improving the health of ecosystems, important natural resources and communities during the times of the pandemic.

The Patagonia Area Resource Alliance, the Sky Island Alliance, the Sonoran Institute, Zero Mass Water and Local First AZ are only five of the many organizations fighting against the odds to ensure environmental resilience despite everything that is happening.

For example, Watershed Management Group launched an initiative called Steward in Place, with the goal of connecting people to projects they can do from home that can help with an array of Tucsons environmental concerns.

According to Shepard, this resilience is at the core of environmentalism.

To be an environmentalist means youre an optimist."

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Five organizations in southern Ariz. continuing to pursue bold environmental projects amid the pandemic - Arizona Daily Wildcat

Jacquire King on Combining New Technology and Human Performance to Find The Organic Grid – Twice

Nashville, TN, June 30, 2020 Whether lending his aural sensibility to breakthrough releases like Kings of Leons Only By The Night and Modest Mouses Good News For People Who Love Bad News or capturing intimate moments in the studio with eclectic singer-songwriters like Tom Waits and Norah Jones, producer/engineer Jacquire King has made his mark in music by knowing how to use the right combination of a classic analog recording sensibility with the latest in digital technology. By employing variations of this combination to suit the artists he works with, King has been able to create recordings with unique and contemporary sonic identities, something that he sees as vital to their success and longevity.

The DNA of modern recording

Kings combinative approach to the analog and the digital were born out of his own sensibilities as a listener. Raised on rootsy genres like classic rock, rhythm and blues, and soul music gave him an appreciation for passionate, human performances. At the same time however, King was drawn to the production creativity of golden age hip-hop and early electronic records for their sonic boundary pushing as well as their ability to reclaim these human elements in different contexts. This gave him a taste for seeking out ways to combine an old school sensibility with the latest sonic flavors that he could get his hands on to keep things fresh and interesting. My philosophy as a producer and engineer is to find the most powerful combinations in the studio between sound and technique in order to move us towards a creative outcome, King said. This ensures that the artists will have a successful experience and that the end listener will be hearing something with a unique sonic stamp.

Another key part of ensuring a unique sonic stamp on his productions comes from preserving the relationship between performers on the initial performances, something King says also informs the work to follow. The relationships inherent in a performance and the way that people play together has its own unique grid and personality, he said. When you make the relationships a part of the DNA of the recordings it creates a unique identifier and everything you add on after the fact is informed by that identity.

Building off the organic grid from there, King will often add programmed percussion and other elements to flesh out the sonics of the song. Doing so allows him to add depth and detail to the arrangements, something that the performers themselves will often key off of when adding overdubs later on. Having those elements can help give them something to react to when performing, he said. It elevates the moment for the performers to have all that texture and youll sometimes get stronger performances out of it.

Accuracy and precision

King primarily works out of his private studio just south of Nashville. He uses a combined analog and digital signal flow, often tracking to 2 tape while mixing in Pro Tools with a Quad 8 desk. A meticulous listener, King started using Amphion Two18 speakers for his monitoring needs in order to ensure that he was getting the most accurate response possible. I was hosting a Mix with the Masters and one of the attendees strongly suggested I check out the Amphion line, he explained. Soon after, I had the opportunity and I was immediately blown away by how precise they felt. It was totally different from any other monitor that I had heard before.

King had previously used many different types of monitors but had struggled to find one that was giving him the accuracy and truth that he needed for his mixes. I dont like the modern take on the studio monitor because it makes everything sound good, he said. When that happens, you arent working as hard as you should be to manage your frequency spectrum and you end up having a lot of translation issues.

Since he began using Amphion four years ago, King says that hes been able to trust his ears much more and that his workflow has benefited from the clarity and honesty. They are incredibly accurate speakers and theyve been a real lifesaver for me, he said. Previously I was mixing a song a day. Now I know I can trust the frequency response and crossover points so much that Im mixing two or three songs a day and getting way fewer notes back from clients.

I trust then more than any monitor Ive ever had, he continued. It helps me to mix with confidence, and at the end of the day they just disappear and help me move at the speed of my creativity.

All photos credited to Mad Love Photography.

For more information about Jacquire King, please visit: http://www.jacquireking.com/

For more information about Amphion, please visit http://amphion.fi/

About Amphion

Amphion Loudspeakers Ltd. was established in 1998. We design and build loudspeakers that are characterized by honest and accurate sound reproduction. Precise driver integration ensures world-class imaging and phase coherency. Controlled dispersion technology helps achieve more stable results in a variety of room acoustics. All products are handmade in Finland (and the Amphion amplifiers are assembled in Finland) to ensure enduring listening quality.

This section of TWICE, The PR Wire, contains original press releases that reflect the views of the industry organizations issuing them. Releases are not reviewed or edited by TWICE editorial staff. Suppliers, The PR Wire is A Virtual Press Conference.

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Jacquire King on Combining New Technology and Human Performance to Find The Organic Grid - Twice

askST@NLB podcast looks at new ways of working – The Straits Times

With most workplaces shut to stem the spread of Covid-19 during the circuit breaker period, the importance of flexible work arrangements and the use of technology to facilitate remote working came under the spotlight like never before.

Now, as Singapore has entered phase two of reopening its economy, working from home continues to remain the default for most employees.

In the third episode of the askST@NLB podcast series, The Straits Times' manpower correspondent Joanna Seow, along with Singapore Human Resources Institute president Low Peck Kem and Singapore National Employers Federation executive director Sim Gim Guan, considered these new ways of working, as well as the sustainability of the current workforce.

"It took us a crisis to get us going in the direction (of greater digitalisation)," said Ms Seow, adding that this could bring about "transformation in essential service sectors like healthcare, cleaning and public transport". Jobs in these sectors will soon become less labour intensive, owing to telemedicine, robots and autonomous vehicles.

Mr Sim said companies should transform the way they do business. "They will need to upskill and reskill their workers, so that they can take on new jobs or new ways of doing their job," he added.

Aside from acquiring skills in information and communication technology, employees should equip themselves with relevant "analytical, conceptual and evaluative skills", along with interpersonal skills that could help improve their employability, said Mr Sim.

By leveraging technology and redesigning work processes, Singapore will be able to focus on productivity and reduce its reliance on both foreign and local manpower. This is pertinent since the citizen working-age population is expected to shrink from around this year.

To address this, Singapore should "tap older workers, as well as those who are economically inactive", explained Mr Sim. This is where flexible work arrangements will prove crucial.

Many older workers tend to favour part-time work. Those who are economically inactive mainly comprise female workers who have exited the workforce for family and caregiving reasons. Hence, having flexi-work arrangements and schemes like the Professional Conversion Programme could ease them back into the workforce.

Ms Low introduced the idea of "productive longevity" - that living longer entails having people "work longer to ensure (their) retirement adequacy".

"When more services can be delivered digitally or virtually, biases like age, looks, nationality and geographical location get diminished, so people in their 60s or 70s who want to remain active and productive can continue to do so," she said.

The fourth episode of the askST@NLB podcast series, slated for July 3, will feature Straits Times senior food correspondent Wong Ah Yoke and hotelier-restaurateur Loh Lik Peng.

It is titled: The new normal in restaurant dining. The episode will examine how the Covid-19 pandemic has transformed the food and beverage landscape in Singapore.

Readers can send in their questions for the speakers by 6pm on June 28 at str.sg/JPXG.

In the meantime, in order to ensure that flexible work arrangements remain sustainable, especially working from home, a relationship of trust has to be established between the supervisor and the employee. Ms Low stressed that supervisors should seek to understand the challenges of older employees "and provide them with the assurance that (they) will walk the journey with them to have them accustomed to the new way of work".

The 25-minute podcast, which is part of a collaboration between ST and the National Library Board, was released yesterday and is available for free on Spotify, Apple Podcasts, Google Podcasts, the ST Facebook page, radio station Money FM 89.3 and at str.sg/JWfR.

The talks were previously held at the Central Public Library in Victoria Street but they have now become a podcast series recorded remotely in the light of safe distancing measures to guard against Covid-19.

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askST@NLB podcast looks at new ways of working - The Straits Times