Afraid of touching objects amid COVID-19? This Virginia Tech professor has a solution – Richmond.com

Since earlier this year, William Ducker has not liked going to the supermarket and navigating a shopping cart around the aisles.

Everybody is very worried about touching communal objects, and Im one of those guys, said Ducker, a professor at Virginia Tech.

But unlike everybody, Duckers field of expertise made him realize he could alleviate that worry.

Im a surface chemist. ... I look at surface coatings, he said. I thought I could fix this problem.

So Ducker and a team of graduate students at Tech created a liquid coating that destroys SARS-CoV-2, the virus that causes COVID-19, when the coating solidifies on everyday items such as doorknobs and pens.

The thin layer of copper-based coating retains its virus-disabling property for at least six weeks, meaning such surfaces would no longer need frequent cleanings. Ducker says he thinks the coating could be effective for years but is only confident about a few weeks because the coating has only existed for that long.

Last week, Ducker and colleagues became one of the first teams if not the first to publish an academic paper showing that such a coating is effective against the new coronavirus. A Surface Coating that Rapidly Inactivates SARS-CoV-2 appeared July 13 in ACS Applied Materials & Interfaces, a journal published by the American Chemical Society.

The surface coating is made from particles of cuprous oxide, which can be made out of recycled copper pipes and wires, bound with polyurethane, a varnish commonly used to finish wood.

Although previous research has established cuprous oxide as effective against viruses, SARS-CoV-2 is a novelty. While conducting a Google Scholar search on the longevity of the virus on surfaces, Ducker came across the research of Leo Poon, a professor at the University of Hong Kong and a leading expert on emerging viruses.

Ducker emailed Poon: Would he be interested in testing the new coronavirus on his coating? Poon replied about 20 minutes later, and they began a collaboration.

Honestly, I was unbelievably excited when Poon said he agreed to test it, Ducker recalled. And then after we found out it worked, oh my God, I was just so excited. I think this is just such a great thing.

After about an hour on glass or stainless steel painted with the coating, the effectiveness of virus samples was reduced by about 99.9% on average, the paper says.

Poons team put bits of SARS-CoV-2 in little drops that mimic as a respiratory droplet which is how COVID-19 spreads and plopped them on the coated surfaces. After varying periods of time, they lifted off the droplets and measured their virality by attempting to infect a monkey kidney cell, a standard mimic of a human cell.

After being exposed to the coating, droplets could no longer infect the monkey cell, Ducker said.

Swapan Ghosh, a polymer scientist in India who has developed a silver-based anti-viral coating, said the novelty of the paper lay in the experiments ability to test it on SARS-CoV-2.

Its good work, because in this pandemic its very diligent work, so I appreciate it Ghosh said.

Ghosh questioned whether the surface coating would work in the dark, since light activates the antiviral properties in cuprous oxide. He also wondered whether the toxicity of the copper elements should be measured.

Ducker agreed testing the coating in the dark would be interesting but doesnt foresee that happening because the experiments are done in high-level biological safety labs that make such a test tricky. .

The actual product, I think what Im after, is people being and feeling safe, Ducker said, which is why he wants to call the material SafetyCoat. That was always my objective.

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Celebrating neurodiversity in the workplace: The Dell example | TheHill – The Hill

There is a tremendous amount of untapped talent among those in the autism spectrum community who stand ready and able to contribute to the workforce. Thanks to an increasing number of companies who value a culture of diversity and inclusion and go the distance in implementing the proper accommodations, there is less untapped talent and more bright, motivated autistic folks at work than there would be otherwise. Dell Technologies is one such company.

It comes as no surprise that Dell has chosen to pursue a culture of neurodiversity. CEO Michael Dell has been quoted as saying diversity and inclusion helps drive innovation and growth, and is critical to the long-term success of our company. I'm proud of the legacy we are building as an employer of choice for all. New ideas from a diversity of perspectives result in a greater capacity for problem solving. New ways of thinking are incorporated into the technology offerings, fostering greater accessibility. And the autistic employees benefit as well. As such, Dell's Autism Hiring Program is a win-win-win proposition: for the company, for its people and for its customers.

When asked to speak about their employment experience at Dell, a few of the autistic members of Dells workforce have had wonderful things to say, as have their nonautistic colleagues. These folks admit to being eager to learn and to try new things. They value having an impact on those around them and being able to teach others. Dell affords them these opportunities, and taking advantage of them instills in them a sense of fulfillment, empowerment, belonging and connectivity with their colleagues. The business impact of these outcomes is the enhancement of team spirit, cohesion and focus.

There are abilities which are prevalent among many on the autism spectrum, including me, which lend themselves well to careers in technology. Attention to detail, commitment to quality and consistency and capacities for analytical and "outside the box" thinking are common. I would not be half the information technology consultant I am today if it werent for these skills and work habits. With respect to commitment and consistency, there is a correlation between these and longevity at a company. Dell reports a significantly lower turnover rate among its autistic employees. I am in my 25th year of employment at my company, largely because I see value and take pride in loyalty, and because I prefer the predictability and structure associated with going to the same workplace, working with familiar people and attending to the same kinds of tasks day after day. The evolution of the technology with which my colleagues and I work has kept the job interesting and stimulating over the long term.

When Dell launched their Autism Hiring Program in 2018, they recognized the need to re-think the hiring process and how to best attract talent. They chose to partner with an organization connected to the Autism Resource Center (ARC) of Philadelphia, known as Neurodiversity in the Workplace (NITW) in order to achieve these goals. The Neurodiversity in the Workplace Initiative connects autistic folks to jobs that fit their skill sets. NITW partners with Human Resources departments in helping to identify the right candidate(s) for the companys open position(s). They support managers and other nonautistic co-workers as to how to best interact and work with new autistic hires.

Candidates are thoroughly prepared for long-term careers. They are trained to advocate for themselves which promotes independence. They learn how to manage differences between how they and their coworkers process sensory input. Emotional regulation and expression, understanding the unwritten rules of the workplace, teamwork with managers and colleagues, and navigating e-communications are also addressed. NITW helps implement an onboarding process after the hire is made, providing onsite training as necessary to ensure success. Finally, the organizations work in supporting a neurodiverse workforce is promoted to the community.

Dell's Autism Hiring Program was first put to the test at one of their Massachusetts-based locations and was later implemented at the companys headquarters in Texas as a result of its initial success. The program allows candidates to demonstrate their skills outside the traditional job interview which is often problematic for folks on the spectrum. Interview proficiency requires both strong verbal and nonverbal communication skills. The latter is a particularly common challenge for autistic people, and I am no exception.

Throughout my youthful years and into adulthood, I didnt even understand what nonverbal communication entails, much less be competent at it. I could only comprehend spoken words and only the most obvious gestures, like how somebodys face looks when she is angry or overly excited. Relatively subtle and nuanced forms of nonverbal communication almost always eluded me, and so I would be unable to respond accordingly. As such, I did not fare well when it came to dating and romance. I cant even recall having kissed a woman with my eyes closed during my bachelor days, not once. If I did, it was purely by coincidence, and without any awareness of what I was actually doing. Considering that a date and an interview have much in common, certainly with respect to body language, it becomes evident that a traditional job interview will often fall short of doing an autistic candidate justice, leading to unfavorable and misleading yet all too important first impressions. Kudos to Dell Technologies for recognizing this reality and for offering a more equitable path to employment.

Candidates entering the Autism Hiring Program are initially screened for their interest in the open employment opportunities and for the pertinent skills, experience and qualifications. If they qualify, they are invited to a two-week skills assessment/mentorship session. Those who succeed move on to a 12-week Summer internship from which several have been hired as full-time Dell employees. Cyber-Security, Artificial Intelligence and Software Engineering are among the technology areas that are taught during the internship. Ample opportunity exists within this kind of framework for candidates to showcase their talents, prove what they are capable of, build self-esteem and grow along the way. No high stakes all or nothing job interview which, if it happened, could very well deny the organization of a worthy asset.

Now is as good a time as any for more companies to follow Dell Technologies example and that of other companies who implement accommodations for neurodiversity in the workplace. Folks on the autism spectrum and others who are neurologically different (including people diagnosed with ADHD) are all too often overlooked because they are typically not thought about by those who make recruiting and hiring decisions. And yet, neurodivergent people who are able and ready to get to work represent phenomenal levels of untapped talent and potential eagerly waiting to be put to use. Consequently, the unemployment rate is regrettably and disproportionately too high among neurodiverse individuals. Now is the time to re-imagine who can be successful members of the workforce and how to best bring them in.

SamFarmerwears many hats, among these father, husband, musician, computer consultant, and autism spectrum community contributor. Diagnosed later in life with Aspergers Syndrome, he writes blogs and articles, records coaching videos, and presents at conferences, sharing stories, ideas, and insights as to how one can achieve greater happiness and success in life despite facing challenges and adversity that often interfere in these pursuits. To learn more, visitsamfarmerauthor.com.

A Long Walk Down a Winding Road: Small Steps, Challenges, & Triumphs Through an Autistic Lensis available on Amazon and can be purchased at all major booksellers.

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Dog years – The County

PetBulletin

(Image: Metro Creative)

(Image: Metro Creative)

Gail Wieder, Special to The County July 22, 2020

We all would like our dogs or cats to live forever, but we know that is not possible. When we lose our beloved pet, it is truly devastating for the family members.

We all would like our dogs or cats to live forever, but we know that is not possible. When we lose our beloved pet, it is truly devastating for the family members.

I have lost some wonderful dogs over the years; the oldest one was Lucy, a sweet terrier mix that lived to be 19 years old. The youngest was a shepherd mix named Snoopy, and he was 10 years old. They were special pets that certainly captured our hearts.

Have you ever wondered how a dogs age compares with human age? I have always thought that taking the dogs age and multiplying it by seven would give you the age of your dog in human years. I was reading an article the other day on CNN Breaking US & World News that said there is new research published in the Cell Systems journal that debunks that method. And that is because the scientists behind a new study say dogs and humans dont age at the same rate.

Researchers at the University of California San Diego School of Medicine have developed a new formula that takes into account that variance. Tracking molecular changes in the DNA of Labrador retrievers and, in particular, the changing patterns of methyl groups in their genome, according to a press release, the study shows how dogs age at a much faster rate than humans early in their lives, then slow down after reaching maturity.

This makes sense when you think about it. After all, a 9-month-old dog can have puppies, so we already knew that the 1-7 ratios werent an accurate measure of age. Based on the study, a one-year old dog compares to a 30- year old human, and a 4-year-old dog to a 52-year old human. The rate of aging decreases after dogs turn 7.

The new formula is the first that is transferable across species. Scientists plan to test their findings on other dog breeds to study the impact of longevity on their findings.

Although breed, size, life circumstances, and plain old luck all play a role in pet longevity, there is still plenty that a pet owner can do to prolong the life of his or her best pal. Keeping your pet at a healthy weight, exercise, spaying and neutering, regular wellness exams and making sure your pet is up to date on all vaccines are just a few things to keep in mind.

Please check out the Central Aroostook Humane Societys Facebook page for pets that are available for adoption. Please call ahead for an appointment at 764-3441.

Please be responsible spay and neuter your pets.

Dogs lives are too short, their only fault, really! Agnes Sligh Turnbull

Gail Weider is a member of the board of the Central Aroostook Humane Society.

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Audit: NCDOT overspent on raises by nearly $40M – matthewsminthillweekly.com

By Nyamekye Daniel

(The Center Square) The N.C. Department of Transportation spent $39 million more than it should have on pay raises in 2018, a newly released state audit found.

State Auditor Beth Wood said NCDOT did not follow state law that directs the agency to issue certain salary adjustments to employees as long as they forfeited lump sum payments based on seniority and do not exceed payroll expenses by 2%, or $11.7 million.

Wood said NCDOT issued $58.5 million in salary adjustments to more than 7,000 employees for the fiscal year that started July 1, 2018. As a result, Wood said NCDOT gave its employees an unfair advantage.

NCDOT Secretary Eric Boyette said the auditor misinterpreted the law, which launched a pilot program that helps retain state employees.

Boyette said employees were not required to relinquish their career status or longevity pay to get the pay raises. Longevity pay is annual 1.5% to 4.5% bonuses given to employers with at least 10 years of service.

Boyette said the law allowed employees to be exempt from State Human Resources Commission rules that dictate compensation for hours worked, paid time off, sick leave, promotions, transfers and incentive pay.

The pay increases that are meant to make the salaries competitive with the private sector would be superfluous if they were contingent on employees giving up the longevity pay or their status as a permanent employee, Boyette said.

Boyette contends the pilot program, which ended June 30, allowed NCDOT to use 2% of its funding and reserves to issue the pay raises, according to the agencys interpretation of the law. He said NCDOT confirmed with lawmakers before and after the legislation was approved. Raises that consist of 2% of the agencys payroll would not have allowed the salaries to be competitive with the private sector, Boyette said.

The law states: For the 2018 2019 fiscal year and the 2019 2020 fiscal year, the sum equal to 2 percent of the total Highway Fund and Highway Trust Fund appropriation for the applicable fiscal year for the payroll expenses of the Department may be used.

The state auditors office confirmed the intent of law with the Joint Legislative Transportation Oversight Committee and the General Assemblys Fiscal Research Division. It also was published in the Joint House and Senate Committee on Appropriations Conference Report in 2018.

It states NCDOT has the flexibility for a period of two years in setting salaries for DOT employees who voluntarily relinquish longevity and career status. It also enables DOT to use up to 2% or $11.7 million per payroll for the purpose of salary adjustments, reallocation of positions, retention and recruitment programs.

Wood said the legislative oversight committee should review the process and the agency needs to correct the mistake.

The audit, which was released July 8, is the second critical state audit of NCDOT this year.

Wood reported in May the agency spent $742 million over its $5.9 billion spending limit for fiscal year 2019 and maxed out its cash balances. The General Assembly passed a bill last month that increases financial oversight of NCDOT.

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Q&A: Rising Star Jxdn On His Friendship With Travis Barker And Overcoming Depression – Forbes

Rising star Jxdn (Jaden Hossler) and Travis Barker, who signed Jxdn to his DTA Records label.

Talk about a whirlwind year. Rising star Jxdn (whose real name is Jaden Hossler) is well on his way to biopic status at only 19. Don't believe me? Then how is this for the opening of a movie?

A kid living in Texas until the age of 14, moves to Tennessee, battles depression and overcomes two suicide attempts, moves to L.A., falls in love with music at a Juice WRLD concert and less than a year after that show is the first singing to Travis Barker's DTA label. and is personally taken under the rock icon's wing.

That is a hell of a start to a movie. For act two, Jxdn has released now three successful singles "Comatose," "Angels & Demons" and the latest, "So What," which features Barker and Machine Gun Kelly in the just released video.

But every great biopic needs a story of redemption of some kind. And Jaden Hossler is living that right now every day as I found when I spoke to him. I have known Barker for many years and have had numerous conversations about appreciating life after the plane crash that nearly killed him. So talking to the wise beyond his years Hossler about his gratitude and humility about his rapid rise to upcoming stardom it is no surprise that he and Barker have become kindred spirits.

I spoke with Hossler about his depression, his Juice WRLD fandom and how signing with Barker's DTA Records was the best decision he ever made in his life.

Steve Baltin: How is it going your first year in L.A.?When you have Travis Barker showing you around L.A. that is a good way to get introduced to the city.

Jaden Hossler: Yeah, it's been amazing. The whole thing with Travis happened probably last February. And since then it's been a lot easier for sure cause I got a big bro showing me around. It's been awesome.

Baltin: I heard from him how you came together. I'd like to hear it from your perspective as well.

Hossler: Basically I came out with my first single, "Comatose," February 26. The day after that I get a call from Travis, who was the first person to call us. It was a Wednesday morning. And he tells us, "My son just showed us this song," along with my producer, who produced it, who was an old friend of his. So it was two parts of his life coming together at once is how he describes it. And so he checked it out. He was the first catalyst of the movement. People heard about that, so all the record labels started hitting us up. So we flew to New York, did that whole process, came back out to L.A., met with everyone here, Interscope, Capitol, a bunch of different people. I thought we kind of had our mind made up, then I met with Travis in person. It was like, "Oh man, this is the guy I need to be with." We went to his vegan restaurant at Crossroads and that's when it settled for me this is the dude. He's so real, so humble and the fact he can be that way after doing everything he's done and working with all the people he's worked with, the fact he chose me to be his first signee, it's still a blessing to this day. But at the moment it was the biggest blessing I've ever had in my life. So we went with Travis and thank god I did because it was the best decision I think I've ever made. It's been awesome.

Baltin: Do you feel like you are learning more because he has been through so much in his own career he can share with you?

Hossler: He's more than just an artist at this point for me. He's like one of my best friends at this point. He's an engineer, a producer, a band member, a dad, a son, he's everything combined into one person. And like you mentioned the humility of everything, that is one thing I really try to harp on at this point because growing up as kids we're all entitled to our own pride at a certain point in our lives. And I definitely was living in that for a good portion of my life. Then I hit the lowest point when I hit a really deep depression. And I had near-death experiences myself, so the fact I get to connect with him with that on a real level speaks a lot more than numbers. I don't know everything at all and I will never say I do. Maybe before when I was in high school I might say I did. That's just me in my ignorance. Now that I've come out and live on my own in the real world, actually left the south for the first time, I realize that I do not know everything. And to have someone that basically kind of does is really nice because he lets me live my own life, give my own opinions and tells me whether they're gonna work or not. Even in the studio I'm like, "I really want to change this melody like this." And he goes, "No, dude, I'm telling you, you need to keep it like this, it goes better with everything." And then we end up going with what he says because I trust him beyond anything and he's right. So I love having that so much.

Baltin: Do you feel like having gone through depression and near-death experiences you have a different appreciation for where you are today?

Hossler: Absolutely, this is one thing I try to preach to other people because I've learned it myself. pain is a very important thing for people. A lot of people try to run from it. I did for most of my life, but you can't escape pain. What you can do is choose how you let it affect you. You can either let it destroy you or you can let it change you and help you become a better person. To my experience there was a lot of hate in my heart growing up. I went through a lot of things that drove me to hate myself and everyone around me. I didn't have appreciation for human life or anything like that. And then my senior year a situation happened with a very close person in my life that drove me to the darkest depression I've ever had in my life. I was really involved in school and in sports and my senior year I just dropped it all. I didn't go to school for like four months. I didn't even really leave my room. I lost like 20, 25 pounds, tried to commit suicide like twice. I really just didn't have any grasp at life. But after that last attempt and it just didn't work it really brought me out of this selfishness that I really just kind of surrounded myself with. Everything I was doing at that point was for myself and after that, one, I vowed to myself I would never lie. Before I lived off of lies and manipulation. I stopped lying, which people are scared about not lying because it could hurt you in the moment. But I promise it's so much better in the end if you'll just be honest to yourself and other people. Then two, I just started loving people.

Baltin: When did it change for you?

Hossler: It all came to fruition when I was at a Juice WRLD last July and in the middle of moshing to the song "Empty," which is tattooed on my arm, he is like my idol, the line, "I'm empty, I feel so goddamn empty," it opened my eyes in the middle of a mosh pit, just thousands of people were screaming this line. These kids, Juice WRLD and myself were all feeling this. They genuinely feel it. I realized I have to do something with music because I know how powerful it is. That moment is when I decided I want to start making music. I went in the studio, started making music and a couple of months later I released my first single, "Comatose." That's really how everything started snowballing. I chose rock music because it's authentic.

Baltin: Take me through some of the upcoming music.

Hossler: There is hope and that's what I want to give in my music. After "So What," I have a song called "Pray," which I'm really excited about because when you hear it you'll understand what I mean about how real it is. It just talks about the point in my life where I really just wanted to die. I wrote the first half of it a while back and then I just finished it like a week or so ago. And there's a complete shift. One I go up a couple of octaves and, two, I use the same word pattern and cadence, but I switch the words. So for instance I'll even give you an insider [preview]. One of the lines is, "I pray to god, let me die in my sleep." That's the first half of it. Then the second half is, "I pray to god I don't die in my sleep." And it's because I had that realization in my life there is so much more to live for. Drugs aren't the answer, alcohol is the answer, whatever you try to fill that void with is not the answer. The answer is genuinely finding a joy that it longevity and sustaining for yourself. For me that's loving other people, caring for other people, seeing the good in people when there is so much bad for everyone. And that's what I'm trying to implement in my music. That's what I'm doing.

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’70s Springsteen vs. ’80s Springsteen: Which Is the Better Boss? – Ultimate Classic Rock

Bruce Springsteens first LP, Greetings From Asbury Park, N.J., was released on Jan. 5, 1973. Its arrival set into motion the career of one of musics biggest icons.

Throughout the ensuing decades, Springsteen would elevate to stardom on the back of his distinctive brand of American rock. His poetic lyrical style, coupled with an uncanny ability to create memorable hooks, led to the creation of many timeless tunes.

Like all artists who enjoy career longevity, Springsteens sound has evolved over the years. At various times, the Boss indulged in forays into folk, blues and even pop sounds.

Springsteens initial breakout came with 1975s Born to Run, an album that announced his arrival among rocks elite. Still, the best-selling of his LPs came nine years later, with the smashing success Born in the U.S.A.

We asked UCR writers to look at Springsteens two most definitive eras - the 70s and 80s - to determine which version of the Boss was best.

Was Springsteen better in the '70s or '80s, and why?

Michael Gallucci: This is close, but I'm going to say the '80s. The four albums he released that decade are more diverse than the four '70s records. All are great, but he reached his peak in the '80s, when he recorded a whirlwind double LP with the band, a harrowing solo acoustic album, a stadium-filling commercial juggernaut and a stripped-down personal work based on the deterioration of his marriage.

Nick DeRiso: The 80s, and its not really close despite the fact that the decade doesnt contain his single greatest album. The difference was how consistently great, and consistently different Springsteen was from project to project. The River carried over every element of his 70s genius, Nebraska took his muse to brutally honest new places, Born in the U.S.A. provided a time-specific stadium-sized outgrowth for the lost souls from Born to Runand Tunnel of Love stripped it all away to reveal the most personal of revelations.

Dave Lifton: The '80s get a slight advantage because he had a greater command of his craft. I love the wide-eyed romanticism of the first three albums, but Greetings From Asbury Park, N.J.is inconsistent. By the time The River hit, he knew what he wanted to say and how to say it. And the older I get, the more weight Nebraska and Tunnel of Love gather.

Corey Irwin: Give me 80s Springsteen. Like many artists,he spent his early years finding his voice and fine-tuning his songwriting. Yes, there were plenty of moments during the 70s in which Springsteen showed a glimpse of the icon hed become. Born to Run is still a fantastic LP and I think people often forget how good Darkness of the Edge of Town is. Still, his first two albums were uneven, and I dont think he truly figured out how to harness his prowess until the end of the decade. Conversely, the 80s featured much of his greatest work, from both a commercial and artistic perspective. The variety of material was also more impressive - from boisterous rock anthems to haunting acoustic tracks. Springsteen was great in the 70s, but its the 80s that made him the Boss.

Was Springsteens transition to politically-inspired material wise?

Gallucci: It wasn't too big of a stretch for him to move his repressed characters into more political territory. After a while, it becomes clear that everyday problems - whether job-related or more personal ones - can't be separated from politics. It's there in the anguish faced by both criminals and enforcers in Nebraska, and it's there in the scarred war vets and weary blue-collar workers of Born in the U.S.A.Besides, it's always been there: "Lost in the Flood" from his debut is about abeaten-down war vet.

DeRiso: Who says Springsteen wasnt always political? Those early characters' lost dreams didnt get lost all on their own.

Lifton: I think calling it a transition is a bit overblown. You can find social commentary on Greetings ("Lost in the Flood," "It's Hard to Be a Saint in the City"), and there are really only two songs on Born in the U.S.A. that are directly about issues, with a few others that touch on them. In between are records filled with stories about people struggling with the cards that they've been dealt, and that goes across Democratic and Republican administrations. With the exception of when he unintentionally got pulled in to the 1984 presidential campaign, the only really political thing he did was the Human Rights Now! tour.

Irwin: Many fans cringe when their rock idols venture into politics. I get it, people turn to music to escape societys problems, not be reminded of them. Still, I dont think the old stick to music mantra works with Springsteen. His developing social consciousness in the late 70s coincided with broader depth to his lyrics, allowing him to create some of the best work of his career. He needed that subject matter to unlock his potential.

Born to Run (1975) vs.Born in the U.S.A. (1984). Which is the stronger album and why?

Gallucci: Born to Run. Every great artist has a signature album, and no other sums up Springsteen as much as his third. It's not only his breakthrough moment, it's also one of the greatest albums of all time, thematically pulled together by some of his best songs and narratives. Born in the U.S.A. is great too, but it tends to move from one place to another. Born to Run, ironically, plants its feet and owns every moment.

DeRiso: Born to Run, if only because it hangs together as one creative statement almost like a book of interconnected short stories in a way that Born in the U.S.A. never tries to. The production style found on Run also feels rooted in rocks greatest, most timeless sounds the 70s, sure, but also very much the 60s while U.S.A., in some ways, locked itself away in the 80s. (P.S.: That said, Ill commit a Springsteen apostasy here by revealing that Darkness and Tunnel of Love are my favorites from these respective eras.)

Lifton: Born to Run is more musically adventurous than Born in the U.S.A. It starts off with a song that doesn't have a proper chorus and ends with a 10-minute epic where the main character gets killed by a woman with whom he just had sex. And there's a reason the house lights come on every night for the title track.

Irwin: Sticking to my 80s fandom, Ill go with Born in the U.S.A. Just look at the depth of material. The title track is one of the most recognizable tunes in rock history, yet it may not even be the best song on the album! Seven songs from the LP were released as singles, all of which reached the Top 10. Chart success isnt the be-all-end-all of quality, but when songs as wildly different as Dancing in the Dark, Glory Days and Im on Fire can all connect with a mainstream audience, you know youre doing something right.

Pick a song from each decade ('70s and '80s) that best represents Springsteen during those respective eras. Explain your choices.

Gallucci: Both decades are best represented by their greatest albums and their respective title tracks. "Born to Run" made Springsteen a star and has served him well over the years, showing up constantly in set lists and as the title of his memoir. It's one of those rare songs that sums up an entire career. "Born in the U.S.A." is definitive '80s Springsteen: anthem-sized, radio ready and a bit weighed down by glossy production. It's emblematic of the period, right down to the LP's famous cover art.

DeRiso: Thunder Road, darker and more serious than the justifiably celebrated Born to Run, reflects the worries of the nation through the eyes of a guy who already feels like life has passed him by. Born in the U.S.A. shows how all of that worry turns into cold, hard truths.

Lifton: Springsteen has often talked about how his music is about people trying to reconcile the American Dream with its reality, and "Badlands" is the best example of that across his catalog. It's just so rousing and uplifting now matter how many times you hear it. And "The River" boils is all down to one phrase: "Is a dream a lie if it don't come true."

Irwin: For the 70s, Im going with Badlands. The song, featured on 1978s Darkness on the Edge of Town, jumps through the speaker with its soaring, anthemic sound. This ambitious style was emblematic of Springsteen in his first decade, helping cement the rocker as a budding star. For the 80s, Ill choose Atlantic City. Far more subdued, but still brimming with energy, the track showcases the Boss evolution as a songwriter, with its minimal acoustic arrangement letting Springsteens storytelling lyrics shine through.

Springsteen famously dismissed the E Street Band in 1989. He wouldnt fully reunite with them for another decade. How do you think that change affected his material in the 90s?

Gallucci: It's easy to claim Springsteen needed the E Street Band to make him great. After all, the two albums he made in 1992 without them are among the worst of his career, and their 2002 reunion LP, The Rising, is a rousing return to form. But 1995's The Ghost of Tom Joad, a solo acoustic record much like 1982's Nebraska, is a striking reminder of what he's capable of with just his voice and a guitar. I'm not sure he would have made this evolution if the E Street Band were still around at the time.

DeRiso: Those were records, and separate adventures, Springsteen needed to have. It certainly informed his failures (1992s Human Touch), but also and this is so often overlooked his successes (parts of 1992s Lucky Town, all of 1995s The Ghost of Tom Joad,) during a period of exploration that only tightened their bond for the perhaps-inevitable E Street Band reunion. I always felt they rallied around each other (and a wounded American city) in ways they might not have on 2002s The Rising without that period of absence.

Lifton: I don't think it did. While the E Street Band would have given better performances on Human Touch and Lucky Town, it wouldn't have been enough to elevate the substandard songs. And, as with Nebraska, the stories he tells on The Ghost of Tom Joad and "Streets of Philadelphia" wouldn't work with big rock arrangements, with the exception of "Youngstown."

Irwin: The 90s were a weird time for Springsteen. His three albums from that time period dont compare to his efforts in either of the previous decades. Now, I wouldnt chalk all of that up to the E Street Bands absence. After all, he still used some of those musicians at varying points during the 90s. I think that era was just a time for Springsteen to look around and try some new things before refocusing. And it wasnt all bad. Streets of Philadelphia won an Oscar. Thats cool, right?

Link:
'70s Springsteen vs. '80s Springsteen: Which Is the Better Boss? - Ultimate Classic Rock

Global Covid-19 impact on Cellular Reprogramming Tools Market by Top Manufacturers, Demand and Growth Overview 2020 to 2025 – 3rd Watch News

Global Cellular Reprogramming Tools Market Research Report estimates the size of the market for 2020 and projects its growth by 2025. It provides a detailed qualitative and quantitative analysis of the Global Cellular Reprogramming Tools market. And collect useful data for this extensive, commercial study of the Global Cellular Reprogramming Tools market. The global Global Cellular Reprogramming Tools report is a basic hold of information, essentially for the business executives.

Development policies and plans are discussed as well as manufacturing processes and industry chain structure is analyzed. This report also states import/export, supply and consumption figures as well as manufacturing cost, global revenue and presents gross margin by regions like North America, Europe, Japan, China and other countries (India, Southeast Asia, Central & South America, Middle East & Africa etc.)

The Cellular Reprogramming Tools market report provides a detailed analysis of global market size, regional and country-level market size, segmentation market growth, market share, competitive Landscape, sales analysis, impact of domestic and global market players, value chain optimization, trade regulations, recent developments, opportunities analysis, strategic market growth analysis, product launches, area marketplace expanding, and technological innovations.

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Cellular Reprogramming Tools Market competition by top manufacturers/Key player Profiled:Celgene, BIOTIME, Human Longevity, Advanced Cell Technology, Mesoblast, STEMCELL Technologies, Osiris Therapeutics, Cynata, Astellas Pharma, FUJIFILM Holdings, EVOTEC, Japan Tissue Engineering

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Market segment by Type, the product can be split into

General Type

Market segment by Application, split into

Drug DevelopmentRegenerative MedicineToxicity Test

The report offers in-depth assessment of the growth and other aspects of the Cellular Reprogramming Tools market in important countries (regions), including:

North America(United States, Canada and Mexico)

Europe (Germany, France, UK, Russia and Italy)

Asia-Pacific (China, Japan, Korea, India, Southeast Asia and Australia)

South America (Brazil, Argentina, Colombia)

Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

In the context of China-US trade war and COVID-19 epidemic, it will have a big influence on this market. Cellular Reprogramming Tools Report by Material, Application, and Geography Global Forecast to 2023 is a professional and comprehensive research report on the worlds major regional market conditions, focusing on the main regions (North America, Europe and Asia-Pacific) and the main countries (United States, Germany, United Kingdom, Japan, South Korea and China).

In this report, the global Cellular Reprogramming Tools market is valued at USD XX million in 2020 and is projected to reach USD XX million by the end of 2024, growing at a CAGR of XX% during the period 2020 to 2024.

The report firstly introduced the Cellular Reprogramming Tools basics: definitions, classifications, applications and market overview; product specifications; manufacturing processes; cost structures, raw materials and so on. Then it analyzed the worlds main region market conditions, including the product price, profit, capacity, production, supply, demand and market growth rate and forecast etc. In the end, the report introduced new project SWOT analysis, investment feasibility analysis, and investment return analysis.

Market segmentation

Cellular Reprogramming Tools market is split by Type and by Application. For the period 2015-2025, the growth among segments provide accurate calculations and forecasts for sales by Type and by Application in terms of volume and value. This analysis can help you expand your business by targeting qualified niche markets.

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The report also covers competitive developments, such as long-term contracts, new product launches and developments, and research & development activities being carried out various leading players such as company profiles, product picture and specification, capacity, production, price, cost, revenue and contact information in this market. It also provides information regarding various business and corporate strategies adopted by key players to strengthen their position in this market. In a word, the report provides major statistics on the state of the industry and is a valuable source of guidance and direction for companies and individuals interested in the market.

Major Points Covered in Table of Contents:

1 Cellular Reprogramming Tools Market Overview

2 Company Profiles

3 Market Competition, by Players

4 Market Size by Regions

5 North America Cellular Reprogramming Tools Revenue by Countries

6 Europe Cellular Reprogramming Tools Revenue by Countries

7 Asia-Pacific Cellular Reprogramming Tools Revenue by Countries

8 South America Cellular Reprogramming Tools Revenue by Countries

9 Middle East & Africa Revenue Cellular Reprogramming Tools by Countries

10 Market Size Segment by Type

11 Global Cellular Reprogramming Tools market Segment by Application

12 Global Cellular Reprogramming Tools Market Size Forecast (2021-2025)

13 Research Findings and Conclusion

14 Appendix

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Main Aspects covered in the Report->>Overview of the Cellular Reprogramming Tools market including production, consumption, status & forecast and market growth->>2016-2020 historical data and 2021-2026 market forecast->>Geographical analysis including major countries->>Overview the product type market including development->>Overview the end-user market including development->>Impact of Coronavirus on the Industry

Key questions answered in the report-

Which are the high growth market segments in terms of type and countries?

What are the market forecasts and estimates for the period 2020-2025?

What are the major drivers, restraints, opportunities, and challenges in the Cellular Reprogramming Tools Market equipment market?

What are the different strategies adopted by the major players in the Cellular Reprogramming Tools Market equipment market?

What are the geographical trends and high growth countries?

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Rewriting history: New evidence challenges Euro-centric narrative of early colonization – Washington University in St. Louis Newsroom

In American history, we learn that the arrival of Spanish explorers led by Hernando de Soto in the 1500s was a watershed moment resulting in the collapse of Indigenous tribes and traditions across the southeastern United States.

While these expeditions unquestionably resulted in the deaths of countless Indigenous people and the relocation of remaining tribes, new research from Washington University in St. Louis provides evidence that Indigenous people in Oconee Valley present-day central Georgia continued to live and actively resist European influence for nearly 150 years.

The findings, published July 15 in American Antiquity, speak to the resistance and resilience of Indigenous people in the face of European insurgence, said Jacob Lulewicz, a lecturer in archaeology in Arts & Sciences and lead author.

The case study presented in our paper reframes the historical contexts of early colonial encounters in the Oconee Valley by way of highlighting the longevity and endurance of Indigenous Mississippian traditions and rewriting narratives of interactions between Spanish colonizers and Native Americans, Lulewicz said.

It also draws into question the motives behind early explanations and interpretations that Euro-Americans proposed about Indigenous earthen mounds platforms built out of soil, clay and stone that were used for important ceremonies and rituals.

Myths were purposively racist

By the mid-1700s, less than 100 years after the abandonment of the Dyar mound [now submerged under Lake Oconee], explanations for the non-Indigenous origins of earthen mounds were being espoused. As less than 100 years would have passed between the Indigenous use of mounds and these explanations, it could be argued that the motives for these myths were purposively racist, denying what would have been a recent collective memory of Indigenous use in favor of explanations that stole, and disenfranchised, these histories from contemporary Indigenous peoples, Lulewicz said.

The Dyar mound was excavated by University of Georgia archaeologists in the 1970s to make way for a dam. Lulewicz and co-authors Victor D. Thompson, professor of archaeology and director of the Laboratory of Archaeology at the University of Georgia; James Wettstaed, archaeologist at Chattahoochee-Oconee National Forests; and Mark Williams, director emeritus of the Laboratory of Archaeology at the University of Georgia received funding from the USDA Forest Service to re-date the platform mound, which contained classic markers of Indigenous rituals and ceremonies.

Using advanced radiocarbon dating techniques and complex statistical models, modern-day archaeologists are able to effectively construct high-resolution, high-precision chronologies. In many cases, they can determine, within a 10- to 20-year range, dates of things that happened as far back as 1,000 years ago.

Radiocarbon dating is really important, not just for getting a date to see when things happened, but for understanding the tempo of how things changed throughout time and really understanding the complex histories of people over hundreds of years, Lulewicz said. In archaeology, its really easy to group things in long periods of time, but it would be false to say that nothing changed over those 500 years.

Their research yielded 20 new dates from up and down the mound, which provided a refined perspective on the effects that early Indigenous-colonizer encounters did, and did not, have on the Indigenous people and their traditions.

Missing from the mound was any sign of European artifacts, which is one of the reasons why archaeologists originally believed sites in the region were abruptly abandoned just after their first encounters with Spanish colonizers. Not only did the ancestors of Muscogee (Creek) people continue their traditions atop the Dyar mound for nearly 150 years after these encounters, but they also actively rejected European things, Lulewicz said.

According to Lulewicz, the Dyar mound does not represent an isolated hold-over after contact with European colonizers. There are several examples of platform mounds that were used beyond the 16th century, including the Fatherland site associated with the Natchez in Louisiana, Cofitachequi in South Carolina and a range of towns throughout the Lower Mississippi Valley.

However, the mound at Dyar represents one of the only confirmed examples, via absolute dating, of continued Mississippian traditions related to mound-use and construction to date.

Today, members of the Muscogee (Creek) Nation, descendants of the Mississippians who built platform mounds like the one at Dyar, live in Oklahoma. We have a great, collaborative relationship with archaeologists of the Muscogee (Creek) Nation Historic and Cultural Preservation Department, so we sent them the paper to review. It was really well received. They saw, reflected in that paper, a lot of the traditions they still practice in Oklahoma and were generous enough to contribute commentary that bolstered the results presented in the paper, he said.

This is where the archaeology that we write becomes so important in the present. Without this type of work, we are contributing to the disenfranchisement of Indigenous peoples from their history.

This is where the archaeology that we write becomes so important in the present, Lulewicz added. There are no Indigenous tribes in Georgia today as they were all forcibly removed in the 19th century, so to make that explicit link to people whose ancestors once lived all across Georgia for thousands of years is really important. Without this type of work, we are contributing to the disenfranchisement of Indigenous peoples from their history.

Of course, they already knew many of the things we discovered, but it was still meaningful to be able to reaffirm their ancestral link to the land.

In the end, Lulewicz said this is the most important part of the paper. We are writing about real human lives Indigenous lives that we have historically treated very poorly and who continue to be treated poorly today in some cases. With the use of advanced radiocarbon dating and the development of really high resolution chronologies, we are able to more effectively reinject lives into narratives of the past.

Excavations in progress at the Dyar site in Greene County, Georgia, prior to the construction of the Wallace Dam and Lake Oconee in 1978. (Source: Laboratory of Archaeology, University of Georgia)

Archaeologists standing on the platform mound at Dyar before it was excavated prior to the construction of the Wallace Dam and Lake Oconee in 1977. (Source: Laboratory of Archaeology, University of Georgia)

An aerial view of the platform mound at Dyar before it was excavated in 1979. Excavated trenches in the village area of the site can be seen in the lower portions of the photograph. (Source: Laboratory of Archaeology, University of Georgia)

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Rewriting history: New evidence challenges Euro-centric narrative of early colonization - Washington University in St. Louis Newsroom

One virus, diverse impacts: the pandemic and women in central and eastern Europe – Social Europe

Against the backdrop of its specific histories, the impact of the pandemic on women particularly in the Balkans also demands specific attention.

Controlling the Covid-19 pandemic and the immediate healing are the priority. But the pandemic has unearthed fissures and structural deficiencies in our societies and governing systems. It is a wake-up call and an unexpectedpossibly catalyticopportunity to forge a sustainable new European future. The progressive and social-democratic family is advocating transformative policies for a just transition, for a more equitable social Europe, for ambitious and bold recovery plans.

Women have borne a sizeable burden of the pressures of the pandemic and the lockdown. They comprise most medical staff, caregivers, domestic workers, teachers, service and social workers. Lockdown measures have resulted in multiple problems for women and familiesfrom domestic violence and increased childcare challenges, including home education, to financial hardships, especially for part-time and seasonal workers.

Through recognising these differentiated needs and applying a gender-sensitive lens to the recovery strategies and the associated deployment of European Union resources, we can ensure gender-equality concerns are mainstreamed in future policies. Within that, the Central and Eastern European Network for Gender Issues, in co-operation with PES Women, has analysed the specific situation of women during the crisis in the Balkan region and explored solutions to the social and economic challenges they face in the wake of the pandemic.

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This region has gone through five economic shocksif we exclude the Balkan conflict itselffrom the transition period to the 2008 economic and financial crisis. Each has affected the very fabric of societies, with neoliberal measures and diminished investments in social and human capital creating more poverty, especially among the most vulnerable.

Serbia is expecting a deep recession in the autumn, deeper than the one in 2008. This would mean fewer resources, especially for social spending, as governments focus on economic stimuli. In most Balkan countries about a third of the population live under the poverty threshold. Even in a more developed EU member such as Croatia every fourth child, according to UNICEF, cannot afford a hot meal at school. Social transfers and one-off financial injections (in Serbia 100 to pensioners, for instance) are palliative measures.

During the coronavirus crisis family and societal relationships have also been changingfrom the negative rise in psychological and physical violence to the positive intergenerational (even inter-ethnic in Bosnia-Herzegovina) solidarity and support. Multi-generational families in the Balkans are more the norm than an exception, providing care for the elderly and children and mutual family support, including financial. So far these demands have fallen primarily on womens shoulders, howeverboth those who are working outside the home (as a double or triple burden) and elderly female pensioners.

The crisis will be felt more in the social sectors, such as care and education, where women dominate. We are witnessing changing labour patterns, such as home-based work with both parents working from home, women as emerging breadwinners (since most are employed in the service sector), part-time and precarious contracts and a rise in unemployment. These will also affect social patterns of care work (for children and the elderly, with men taking more responsibility), as well as social mobility. They will demand that we revisit our social-welfare systems to adapt to the new circumstances or, at least, address their pitfalls.

We should be ready for a new social stratification as a result of the new economic and social circumstances. The lower-middle and especially the working class will be sliding into poverty. There will also be enhanced polarisation between those working in industrial sectors and those employed in the public sector, especially in terms of contracts, remuneration and job security.

A new stratification is emerging too through the lockdown and online schooling. While governments have made an effort to provide web-based curricula and classes, there is increased evidence of the burden it has created for parents who, apart from being playmates, care-givers, domestics and online workers, had to be educatorsto monitor, if not assist, the childs education and school performance. But limited attention and support was given to children of disadvantaged parents, marginalised children, those living in rural areas without computer and internet facilities and those whose parents are unable to provide guidance and ensure educational support. The gaps created in this situation are still there, including as we look to the autumn.

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An additional problem which has arisen in providing social care has been the declining certainty of remittances from the many who left the region to seek a better future, initially because of the wars associated with the collapse of Yugoslavia and later to seek employment, better wages and working conditions in a more democratic, less corrupt environment. The shortage of medical staff, from nurses to doctors, due to their migration to wealthier countries in western Europe, is meanwhile overstretching health and social-care systems in the region.

Coming back to the wider European canvas, we need to retoolto address the consequences of neoliberal policies for our social-welfare systems, to synchronise the new labour patterns and social structures and to address inequalities, including gender inequalities, and rising poverty. A renewed Europe after the pandemic cannot have gender equality as an afterthought: this must be an integral part of political decision-making and of economic and social policies.

The EU has to support sustainable development and human capacities in its neighbourhood, because we are one continent which needs stability and progress. Maybe this is the opportunity for a Europe-wide restart, akin to that after the second world war yet before the cold war began.

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Expected Massive Growth for Precision Medicine Software Market Explored in this Latest Report | Syapse, Allscripts, Qiagen, Roper Technologies -…

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Will coronavirus lead to automation ruling over human interaction? – Open Access Government

Technology has become a necessity rather than just a nice-to-have during the COVID-19 pandemic. Tasks such as shopping for groceries, booking a taxi, or ordering a takeaway have all been made easier thanks to technological advances. Despite its influence on consumer behaviours, one of the perceived downfalls of automation is the limit it has on the reliance for humans to carry out certain tasks and jobs. A debate that has, and will, rage on for quite some time.

But, as the world has been gripped by the COVID-19 pandemic, will automation continue to be a necessity as we enter the new normal and social distancing. Here we look at the role automation could play in the fight against COVID-19 and beyond.

Following the World Health Organisation reclassifying coronavirus as a global pandemic in March, cities and communities effectively turned into ghost towns. Tourist hotspots, restaurants, entertainment venues, and workplaces shut, with people instructed to stay at home.

In the UK, the job retention scheme was introduced to help ease the fears of businesses who were left to wonder how they would pay their staff and stay afloat. Originally set to last until July, the scheme has now been extended to October an indication that economic impacts of the virus will be felt for some time.

As of yet, its unknown as to whether businesses who rely on humans to come to work and carry out manual tasks will survive a post-coronavirus recession. Will it force company bigwigs to invest in automation to boost their chances of longevity and success?

In April, a study carried out by auditing firm, EY, found that nearly half of bosses in 45 countries are speeding up their plans to introduce automation, with companies such as Amazon and Ocado already using robots in customer fulfilment centres. A challenge that car manufacturers face is a reduction in available staff on their shop floors, which comes with health and safety concerns, and the need for new ecosystems to achieve efficient production. This may see a continued turn towards automation to aid the build of new vehicles.

Its almost inevitable that automation across industries will increase, both during and after COVID-19. To what extent is unknown, but it could play a key role in the way we dine at restaurants, check-in to hotels, and everything else in-between.

You may pose the question: How has coronavirus helped the environment?. In the short-term its had a positive impact, with carbon emissions dramatically falling, creating cleaner air in the process. You may have seen flamingos thriving off quieter roads and the cleaner air in Mumbai, and mountain goats making themselves at home in the streets of Llandudno. But, when this is all over, will our attitudes change, or will we just go back to travelling back-and-forward, pumping out carbon emissions and increasing our carbon footprint again?

If businesses must look at automation, will consumers look towards it when they choose their next vehicle, for example? Choosing an electric vehicle over petrol or diesel means you wont need to visit the petrol station to fill up eliminating human interaction. Plus, youll reduce your carbon emissions to zero when driving. If you have worries over social distancing, knowing that you can e-charge your car at home with the right equipment it may sway you towards a greener lifestyle.

Year-to-date data for 2020 from the Society of Motor Manufacturers & Traders reveals a 131% increase in the registration of fully electric cars compared to the year previously. This shows a potential shift towards a more environmentally friendly future, one that introduces an element of automation at the same time. Manufacturers have already acknowledged this, with BMW, for example, being committed to having no less than 12 fully-electric models in their line-up over the next three-to-four years, with the German brand potentially offering an electric version of their 1 Seriesas early as 2021.

Its likely that automation will become more prominent as we move into the future, but striking the correct balance between automation and human interaction could be key in the short-term to enable economies to bounce back and communities to thrive like they did before the pandemic hit.

Sources

https://www.bbc.co.uk/news/business-52634759

https://news.sky.com/story/flamingos-enjoy-quieter-roads-and-cleaner-air-in-mumbai-11982032

https://www.theguardian.com/world/2020/mar/30/bosses-speed-up-automation-as-virus-keeps-workers-home

https://www.lookers.co.uk/bmw/new-cars/1-series

https://www.theguardian.com/world/2020/mar/30/bosses-speed-up-automation-as-virus-keeps-workers-home

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Vitamin C : Beauty Benefits of This Anti-Aging Powerhouse Ingredient – Longevity LIVE

There are a few ingredients that are always thrown around when it comes to skincare, and vitamin C is definitely one of them. As of late, the only time weve been hearing of vitamin C is in regards to our immune system. However, this ingredient is just as necessary for our skin as it is for our overall health.

The antioxidant helps to address a number of skin concerns and this is why it continues to be a dermatologists best skincare ingredient, and why its constantly found in every lotion, face cream, and serum known to man.

Vitamin C is an essential nutrient used by the body for the growth and repair of tissues. Unfortunately, the body cannot produce it on its own so the best way to get it is through supplements or your diet.

Now while you can eat your way to a healthy vitamin C intake, you cant do the same for your skin. This is because, when it comes to your skin, the topical application of vitamin C works out better than oral intake. In fact, a studypublished in Dermatologic Therapy found that the topical application of vitamin C resulted in 27 times higher levels of vitamin C in the skin than even the highest possible oral intake.

Free radicals are unstable molecules that damage cells, and in doing so, they encourage premature aging, and they may even trigger skin cancer. Being an antioxidant, vitamin C works to protect the skin by working to neutralize free radicals, thus preventingpremature aging and leaving the skin with ayounger and fresherappearance.

Loss of moisture can not only lead to dull and dry skin, but it can also accentuate the appearance of wrinkles and fine lines.

Vitamin C helps the skin retain moisture by supporting the skin barrier. Additionally, magnesium ascorbyl phosphate is a vitamin C derivative used in skincare, and it has been shownto help hydrate the skin (1).

Vitamin C doesnt only have benefits for your skin.

Firstly, it helps to protect your locks from free radical damage (which can cause breakage and hair loss). Secondly, it helps to stimulate the production of collagen. This is an important protein that helps to keep your hair healthy. Lastly, vitamin C helps the body absorb iron, which is a necessary mineral for healthy hair growth.

As we age, the levels of collagen begin to decline and this greatly contributes to the formation of fine lines and wrinkles, as well as a loss of volume. Thankfully, vitamin C helps to stimulate the production of collagen, and in doing so, it helps to reduce the appearance of fine lines and wrinkles.

In fact, a studypublished intheClinical, Cosmetic and Investigational DermatologyJournal found that vitamin C helped to increasecollagen production among study participants in all age groups.

Whats more, its antioxidant properties help to neutralize the free radicals that speed up the breakdown of collagen.

Prolonged sun exposure and poor sun protection wont only accelerate the aging process, but it can also cause skin concerns like flakiness, redness, and sunspots.

One animal studyfound that vitamin C helped to reverse sun damage. If youre interested in human trials, a 1999 study found that a 3-month vitamin C treatment helped participants withmild to moderately photo-damaged skin. In fact, they experienced a significant improvement in skin tone and roughness. As of this writing, there are not any recent human trials looking at vitamin C and sun damage.

Hyperpigmentation happens when the body produces too much melanin in certain areas of the skin. This leaves you with unwanted brown spots and discoloration. That said, if you have concerns about uneven skin tone, vitamin C has been found to address the overproduction of melanin.

According to astudypublished intheJournal of Drugs and Dermatology,participants noticed a73%improvement in skin pigmentation after using vitamin C.

When it comes to buying an effective vitamin C beauty product, there are a few things that you need to remember.

Vitamin C comes in various forms, yet L-ascorbic acid has been found to be the most stable and effective form. That said, when shopping for products, make sure that they list L-ascorbic acid as an ingredient.

For instance, the Skinceuticals CE Ferulic serumcontains 15% L-ascorbic acid and its been found to improve the appearance of wrinkles and appearance.

The concentration of vitamin C also plays a role with research showing that a concentration higher than 8 but lower than 20 is quite effective (2). Take the Exuviance AF Vitamin C20 Serum Capsuleswhich contain 20% L-ascorbic acid and have been found to effectively address skin concerns such as sun damage and dullness.

Vitamin C breaks down when its exposed to light or air. Its important that any product you purchase comes in a dark glass bottle.

The LOral Revitalift Derm Intensive Vitamin C Serumcomes in the form of a metal tube, which helps to keep the product stable, ensuring that it delivers great benefits to your skin.

Store your product in a cool, dark place and away from extreme heat. Additionally, if you notice that the product has become yellow or brown, this means that its been oxidized and is likely going to be less effective.

Vitamin C is more effective if its paired with complementary ingredients, particularly vitamin E and ferulic acid.Ferulic acid has been found to stabilize the powerhouse ingredientwhereas vitamin E helps to boost antioxidant protection.

Paulas Choice Resist C15 Super Boosternot only contains vitamins C and E, as well as ferulic acid, but it also contains peptides, which helps to boost your skin health.

If you have sensitive skin, its best to start with a lower concentration. Reach out to your dermatologist to find a product that is best suited for your skin type.

That said, its also advisable to not use vitamin C and retinol at the same time. This can cause irritation. Rather, use vitamin C products in the morning and retinoids at night.

As lockdown regulations lift, more and more of us are making our way outside. So, for those still battling with skin concerns, these post-lockdown buys will not only prep your skin for the outside, but theyll also help to address skin issues brought on by being stuck indoors all day.

Al-Niaimi, F., & Chiang, N. (2017). The Journal of clinical and aesthetic dermatology,10(7), 1417.

Burke, K. E. (2007). Interaction of vitamins C and E as better cosmeceuticals.Dermatologic therapy,20(5), 314-321.

Crisan, D., Roman, I., Crisan, M., Scharffetter-Kochanek, K., & Badea, R. (2015). Clinical, cosmetic and investigational dermatology,8, 463470. https://doi.org/10.2147/CCID.S84903

Pullar, J. M., Carr, A. C., & Vissers, M. (2017). Nutrients,9(8), 866. https://doi.org/10.3390/nu9080866

Telang P. S. (2013). Indian dermatology online journal,4(2), 143146. https://doi.org/10.4103/2229-5178.110593

Traikovich, S. S. (1999). Use of topical ascorbic acid and its effects on photodamaged skin topography.Archives of otolaryngologyhead & neck surgery,125(10), 1091-1098.

Zussman, J., Ahdout, J., & Kim, J. (2010). Vitamins and photoaging: do scientific data support their use?.Journal of the American Academy of Dermatology,63(3), 507525. https://doi.org/10.1016/j.jaad.2009.07.037

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Vitamin C : Beauty Benefits of This Anti-Aging Powerhouse Ingredient - Longevity LIVE

Bats Have Allegedly Carried Deadly Coronavirus But Not Succumbed to it Because of THIS reason – India.com

Bats which are the carrier of deadly viruses that affect humans like Ebola, rabies, and possibly the SARS-CoV-2 strain of virus that causes coronavirus. However, these viruses have not killed bats but humans. Also Read - Lockdown Extension: As India's COVID Tally Surges to Nearly 8.5 Lakh, Many Cities Come Under Shutdown | Check State-wise Picture Here

Bats are remarkably able to tolerate viruses, and, additionally, live much longer than similar-sized land mammals. What are the secrets to their longevity and virus resistance? Also Read - Maharashtra Lockdown News: Latur City to be Under Fortnight-long 'Strict' Shutdown From Midnight of July 15 | Guidelines Soon

According to researchers at the University of Rochester in the US, bats longevity and capacity to tolerate viruses may stem from their ability to control inflammation, which is a hallmark of disease and aging. Also Read - Kashmir Lockdown News: Another Phase of Shutdown in Srinagar From Monday, Authorities Seal Lal Chowk And Other 67 Areas | Know Here

In a study published in the journal Cell Metabolism, biology professors Vera Gorbunova and Andrei Seluanov described the mechanisms underlying bats unique abilities and how these mechanisms may hold clues to developing new treatments for diseases in humans.

There may be a very strong connection between bats resistance to infectious diseases and their longevity. We also realised that bats can provide clues to human therapies used to fight diseases, said Gorbunova.

The scientists, along with colleague Brian Kennedy, director of the Centre for Healthy Aging at the National University of Singapore, got to talking about bats.

Unlike humans, bats have developed specific mechanisms that reduce viral replication and also dampen the immune response to a virus.

The result is a beneficial balance: their immune systems control viruses but at the same time, do not mount a strong inflammatory response.

Another factor may be their environment.

Many species of bats live in large, dense colonies, and hang close together on cave ceilings or in trees. Those conditions are ideal for transmitting viruses and other pathogens.

Bats are constantly exposed to viruses. They are always flying out and bringing back something new to the cave or nest, and they transfer the virus because they live in such close proximity to each other, said Seluanov.

Because bats are constantly exposed to viruses, their immune systems are in a perpetual arms race with pathogens.

Usually the strongest driver of new traits in evolution is an arms race with pathogens. Dealing with all of these viruses may be shaping bats immunity and longevity.

However, the study does not suggest for humans to toss their masks and crowd together in restaurants and movie theatres.

Evolution takes place over thousands of years, rather than a few months.

While humans may be developing social habits that parallel those of bats, we have not yet evolved bats sophisticated mechanisms to combat viruses as they emerge and swiftly spread.

The consequences may be that our bodies experience more inflammation, said Gorbunova.

Studying bats immune systems will provide new targets for human therapies to fight diseases and aging, said researchers.

For example, bats have mutated or completely eliminated several genes involved in inflammation; scientists can develop drugs to inhibit these genes in humans.

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Bats Have Allegedly Carried Deadly Coronavirus But Not Succumbed to it Because of THIS reason - India.com

Bats Offer Clues to Treating COVID-19 Secrets to Longevity and Disease Tolerance – SciTechDaily

Batsthe only flying mammalsare highly mobile, constantly bringing new pathogens into their communities. According to University of Rochester biologists, thats one reason they have evolved to have immunity to so many viruses that plague humans, who have only recently (in evolutionary terms) come to be highly mobile and more likely to live in densely populated centers.

To combat COVID-19, we need to regulate our immune systems to resemble those of bats.

Bats are often considered patient zero for many deadly viruses affecting humans, including Ebola, rabies, and, most recently, the SARS-CoV-2 strain of virus that causes coronavirus.

Although humans experience adverse symptoms when afflicted with these pathogens, bats are remarkably able to tolerate viruses, and, additionally, live much longer than similar-sized land mammals.

What are the secrets to their longevity and virus resistance?

According to researchers at the University of Rochester, bats longevity and capacity to tolerate viruses may stem from their ability to control inflammation, which is a hallmark of disease and aging. In a review article published in the journal Cell Metabolism, the researchersincluding Rochester biology professors Vera GorbunovaandAndrei Seluanovoutline the mechanisms underlying bats unique abilities and how these mechanisms may hold clues to developing new treatments for diseases in humans.

The idea for the paper came about when Gorbunova and Seluanov, who are married, were in Singapore in March before COVID-19 travel bans began. When the virus started to spread and Singapore went into lockdown, they were quarantined at the home of their colleague Brian Kennedy, director of the Centre for Healthy Aging at the National University of Singapore and co-author of the paper.

The three scientists, all experts on longevity in mammals, got to talking about bats. SARS-CoV-2 is believed to have originated in bats before the virus was transmitted to humans. Although bats were carriers, they seemed to be unaffected by the virus. Another perplexing factor: generally, a species lifespan correlates with its body mass; the smaller a species, the shorter its lifespan, and vice versa. Many bat species, however, have lifespans of 30 to 40 years, which is impressive for their size.

Weve been interested in longevity and disease resistance in bats for a while, but we didnt have the time to sit and think about it, says Gorbunova, the Doris Johns Cherry Professor of Biology at Rochester. Being in quarantine gave us time to discuss this, and we realized there may be a very strong connection between bats resistance to infectious diseases and their longevity. We also realized that bats can provide clues to human therapies used to fight diseases.

While there have been studies on the immune responses of bats and studies of bats longevity, until their article, no one has combined these two phenomena, Seluanov says.

Gorbunova and Seluanov have studied longevity and disease resistance in other exceptionally long-lived animals, including naked mole rats. One common theme in their research is that inflammation is a hallmark of the aging process and age-related diseases, including cancer, Alzheimers, and cardiovascular disease. Viruses, including COVID-19, are one factor that can trigger inflammation.

With COVID-19, the inflammation goes haywire, and it may be the inflammatory response that is killing the patient, more so than the virus itself, Gorbunova says. The human immune system works like that: once we get infected, our body sounds an alarm and we develop a fever and inflammation. The goal is to kill the virus and fight infection, but it can also be a detrimental response as our bodies overreact to the threat.

Not so with bats. Unlike humans, bats have developed specific mechanisms that reduce viral replication and also dampen the immune response to a virus. The result is a beneficial balance: their immune systems control viruses but at the same time, do not mount a strong inflammatory response.

According to the researchers, there are several factors that may contribute to bats having evolved to fight viruses and live long lives. One factor may be driven by flight. Bats are the only mammals with the ability to fly, which requires that they adapt to rapid increases in body temperature, sudden surges in metabolism, and molecular damage. These adaptations may also assist in disease resistance.

Another factor may be their environment. Many species of bats live in large, dense colonies, and hang close together on cave ceilings or in trees. Those conditions are ideal for transmitting viruses and other pathogens.

Bats are constantly exposed to viruses, Seluanov says. They are always flying out and bringing back something new to the cave or nest, and they transfer the virus because they live in such close proximity to each other.

Because bats are constantly exposed to viruses, their immune systems are in a perpetual arms race with pathogens: a pathogen will enter the organism, the immune system will evolve a mechanism to combat the pathogen, the pathogen will evolve again, and so on.

Usually the strongest driver of new traits in evolution is an arms race with pathogens, Gorbunova says. Dealing with all of these viruses may be shaping bats immunity and longevity.

Thats not an invitation for humans to toss their masks and crowd together in restaurants and movie theaters. Evolution takes place over thousands of years, rather than a few months. It has only been in recent history that a majority of the human population has begun living in close proximity in cities. Or that technology has enabled rapid mobility and travel across continents and around the globe. While humans may be developing social habits that parallel those of bats, we have not yet evolved bats sophisticated mechanisms to combat viruses as they emerge and swiftly spread.

The consequences may be that our bodies experience more inflammation, Gorbunova says.

The researchers also recognize that agingseems to play an adverse role in humans reactions to COVID-19.

COVID-19 has such a different pathogenesis in older people, Gorbunova says. Age is one of the most critical factors between living and dying. We have to treat aging as a whole process instead of just treating individual symptoms.

The researchers anticipate that studying bats immune systems will provide new targets for human therapies to fight diseases and aging. For example, bats have mutated or completely eliminated several genes involved in inflammation; scientists can develop drugs to inhibit these genes in humans. Gorbunova and Seluanov hope to start a new research program at Rochester to work toward that goal.

Humans have two possible strategies if we want to prevent inflammation, live longer, and avoid the deadly effects of diseases like COVID-19, Gorbunova says. One would be to not be exposed to any viruses, but thats not practical. The second would be to regulate our immune system more like a bat.

Reference: The World Goes Bats: Living Longer and Tolerating Viruses by Vera Gorbunova, Andrei Seluanov and Brian K. Kennedy, 7 July 2020, Cell Metabolism.DOI: 10.1016/j.cmet.2020.06.013

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Bats Offer Clues to Treating COVID-19 Secrets to Longevity and Disease Tolerance - SciTechDaily

Dune: The giant sandworm, explained – Polygon

Those unfamiliar with Frank Herberts novel Dune might be wondering whats up with the giant sandworm in the first trailer for Denis Villeneuves Dune. Turns out this mysterious critter is secretly the movies main character or at least the alien beast who first set its great conflict in motion. Heres what you need to know about the planet Arrakis, and the giant monstrosities known as the Shai-Hulud.

Sandworms are native to the desert planet of Arrakis, and cant be found anywhere else in the fictional galaxy created by Herbert. First described in the novel Dune, published in 1965, the sandworm were Herberts take on the archetypical beast, like the dragon in Beowulf. Dropping them on to a desert planet was born from his interest in environmental science.

The interdependence in our own environment is quite sketchy, he said in a 1969 conversation with The Dune Encyclopedia author Willis E. McNelly, but we do know this: to create large bodies of sand, dust, whatnot, you need water, so Ive set up multitudes of creatures who substitute for this [...] And I postulated that in one vector of their life circle, water is poison to them. We see this sort of thing on planet Earth right now where a creature can live in one environment, in one vector, but that environment will kill it in another vector. The anopheles mosquito is a good example.

Another of the creatures closest analogue is the annelid, a phylum that also includes the common earthworm. Like the common earthworm, the sandworms in Dune have segmented bodies and are fairly robust. Break off one of the segments, Herbert said, and sand worms can go on living. The only way to kill one is by electrocuting each segment individually, or by hitting the whole thing with a nuclear weapon.

Of course, unlike the varieties of annelid that you might use to bait fishing hooks, sandworms are a lot bigger. The largest portrayed in the original novel is more than 9,000 feet long and several hundred feet in diameter. Youd need a fishing pole at least as long as a Ningi is wide just to cast one off. Incidentally, theyre attracted to vibrations, making driving or even walking on Arrakis sandy surface particularly dangerous. Thats why most folks prefer to travel by ornithopter.

The Fremen human natives of Arrakis dont have ornithopters, however. Theyve adapted to life with sandworms nonetheless. They tend to settle in rocky outcroppings where sandworms cant penetrate. They also employ a seismic device known as a thumper to distract the creatures when the need arises.

Oh. The fremen also ride on sandworms.

Once on the surface, they use a wedge-like device called a maker hook to force a gap between two segments. That lets sand in, irritating the worm and preventing it from diving back down below the surface. With enough hooks the fremen can actually drive a sand worm around like a bus. Its a great way to head into battle especially when you and your friends are armed with giant blades called crysknives, made from the sandworms nearly indestructible crystalline teeth.

Are you grossed out yet? Well, Ive got one more detail for you before you go.

As part of the sandworm life cycle, the creatures larvae produce a substance known as melange. Also called spice, it just happens to be the most important substance in the galaxy. The highly-addictive stuff both tastes and smells like cinnamon. Pound enough of it and it will give you prescience, longevity, and preternaturally blue eyes. Hang out in a tank of it for most of your natural life and you can move spaceships across the vastness of space using only your mind.

Not bad for worm poop. Not bad at all.

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Dune: The giant sandworm, explained - Polygon

Cellular Reprogramming Tools Market to Witness a Robust CAGR Growth Between 2020-2030 – Bulletin Line

The Cellular Reprogramming Tools market study Added by Market Study Report provides an in-depth analysis pertaining to potential drivers fueling this industry. The study also encompasses valuable insights about profitability prospects, market size, growth dynamics, and revenue estimation of the business vertical. The study further draws attention to the competitive backdrop of renowned market contenders including their product offerings and business strategies.

The report gives a far-reaching examination of the Cellular Reprogramming Tools industry advertise by sorts, applications, players and locales. This report additionally shows the 2014-2024 generation, Consumption, income, Gross edge, Cost, Gross, piece of the overall industry, CAGR, and Market impacting elements of the Cellular Reprogramming Tools industry.

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A rundown of the competitive spectrum:

Key Players

Some examples of key participants operating at the global level include Celgene Corporation, BIOTIME, INC., Human Longevity Inc., Advanced Cell Technology Inc, Mesoblast, STEMCELL Technologies Inc., Osiris Therapeutics Inc., Cynata, Astellas Pharma Inc., FUJIFILM Holdings Corporation, EVOTEC, Japan Tissue Engineering Co., Ltd and some others.

The research report on cellular reprogramming tools market presents a comprehensive assessment of the market and contains thoughtful insights, facts, historical data, and statistically supported and industry-validated market data. It also contains projections using a suitable set of assumptions and methodologies. The research report on cellular reprogramming tools market provides analysis and information according to market segments such as geographies, application, and industry.

The report covers exhaust analysis on Cellular Reprogramming tools market:

Report on Cellular Reprogramming tools market includes regional analysis:

The report on cellular reprogramming tools market is a compilation of first-hand information, qualitative and quantitative assessment by industry analysts, inputs from industry experts and industry participants across the value chain. The report provides in-depth analysis of parent market trends, macro-economic indicators and governing factors along with market attractiveness as per segments. The report also maps the qualitative impact of various market factors on market segments and geographies.

In-depth information about the sales volume and the market share accumulated by each of the company, in addition to the revenue margin of every player is elucidated.

A basic outline of the company, along with its chief rivals and its manufacturing base has also been provided.

The report encompasses, in minute detail, information regarding the products manufactured by every company of Cellular Reprogramming Tools market, product specifications, as well as their application scope.

The report is also inclusive the price patterns and the gross margins of the industry magnates.

The revenue and market share accumulated by every region has been enumerated in the report, in addition to the sales forecast and the volume.

The present status of the regional markets in this business sphere in addition to the prospects that every region holds in Cellular Reprogramming Tools market in the years to come has been provided.

The projected growth rate of every region in Cellular Reprogramming Tools market over the forecast timeline has also been discussed about.

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An outline of the Cellular Reprogramming Tools market segmentation:

The report elucidates the Cellular Reprogramming Tools market in terms of the product landscape, split into Medical Service and Medicine Marketing.

Details regarding the revenue amassed by every product in tandem with the volume share have been enlisted.

The market share accumulated by every product in Cellular Reprogramming Tools market has been specified as well.

The report is inclusive of the application landscape of this industry, segmented into Hospitals and Clinics.

The study encompasses the revenue that every application segment accounts for, as well as the volume and market share of the application.

We offer tailor-made solutions to fit your requirements, request[emailprotected] https://www.futuremarketinsights.co/customization-available/REP-GB-11499

The Cellular Reprogramming Tools market report enumerates quite some details about the factors impacting the industry, influence of technological developments on the vertical, risks, as well as the threats that substitutes present to the industry players. In addition, information about the changing preferences and needs of consumers in conjunction with the impact of the shifting dynamics of the economic and political scenario on the Cellular Reprogramming Tools market has also been acknowledged in the study.

Highlights of the Cellular Reprogramming Tools market report:

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Cellular Reprogramming Tools Market to Witness a Robust CAGR Growth Between 2020-2030 - Bulletin Line

Sustainable fashion in the aftermath of Covid-19 – Prism – DAWN.COM – DAWN.com

Covid-19 has dealt a massive blow to most industries fashion and textile being no exception. As countries continue to experiment with lockdowns and the demand for apparel and textiles shrinks, several major international retailers such as Primark and Forever 21 have taken the decision to postpone or cancel orders. In some cases, they have even refused to pay for clothing which had already been manufactured. For a country like Pakistan, which relies on a large chunk of its exports being from the apparel and textile sector, the effects of cancelled and delayed payments can be and have been devastating. Thousands of garment factory workers will be laid off, with most having to return to their hometowns empty-handed and without hope of immediate employment.

This is a grim reality, but in some ways one could see this coming. The fashion industry has been on a trajectory of human rights violations and environmental degradation for quite some time now; the Covid-19 crisis has only made it more obvious, and brought the gross inequalities that persist in the labour market to the forefront.

The global fashion industry is the second highest user of water worldwide, generating 20 per cent of global water waste and is responsible for 8.1 per cent of greenhouse gases produced annually. Thats a lot of damage, especially at a time when scientists and activists world over are doing their best to avert the impending climate crisis.

So now that we can no longer feign ignorance, whats the best way forward?

The answer may lie in sustainability.

According to Kate Heiny, Director for Sustainability at Zalando SE, nine out of 10 Generation Z consumers believe that companies have a responsibility to address environmental and social issues.

"We see a clear link between sustainability and continued commercial success. Our sustainability ambitions will help us stay ahead of customer demand after this crisis caused by the coronavirus. Both our current and future customer base are calling for more sustainable choices in fashion."

While there is no exact definition for the term 'sustainable fashion', it is widely believed to be an amalgamation of environmental, social and financial integrity.

Most businesses put profits at the forefront of their strategy at the cost of human and environmental rights, but sustainable business models consider the profits, people, and planet to be equally important. Special attention is paid towards the quality and longevity of the garments produced, as well as towards the people who are a part of producing it. In addition, a thorough check and balance is placed throughout all stages of the supply chain, including outsourced vendors.

"We work as a community, so I don't quote or dictate the prices," says Waqar J. Khan of Nasheman a local sustainable fashion brand.

"We explain the kind of work we require, and the artisans then quote us a timeline and a price. We plan the rest accordingly."

Before deciding to work with the artisans, Waqar spent a whole week in their village talking to them about how they work as well as their way of life. And as he was speaking to me, Waqar expressed the importance of identifying and understanding not only the strengths of a particular community of artisans, but also its limitations.

"We need to understand that artisans often reside in places with a lack of modern facilities, and have developed their own systems for working efficiently. Our job is to build a partnership based on trust and respect, which ends up being mutually beneficial."

Amneh Shaikh of Polly and Other Stories shares a touching anecdote to emphasise the importance of treating employees as the unique individuals that they are, rather than a means to an end.

"I met Seher* around seven years ago, while working for a project where she used to do handicraft work for her neighbours and occasionally for a factory near her home. When she joined our project, the elders in her community branded her as a 'bad' woman for working outside the house. She persisted nevertheless. Fast forward to now, her daughter is a teacher, she herself runs a business and brings work for 25 other women in her community. It is a transformative story.

Now that I meet her, she says my name is Seher and I am a leader. It makes me want to cry because I remember seven years ago when I met her she used to say 'baaji, I cant do this, and this, and not even that'. Now she doesnt only believe that she can do all the things she was once afraid she couldn't, she believes she can lead others to do them too. Thats how far long-term commitment takes you."

Pakistan is home to centuries old craft techniques and a rich cultural heritage; this combined with its significant artisan base can make it a hub for slow and sustainable fashion. However, we still see our local high-street brands failing to support or respect our craftsmen.

The success of international fast fashion brands such as Zara and H&M has turned the local fashion industry on its head in the past decade. Instead of cultivating our strengths, we have joined the race of over-consumption and disposability. Consequently, our artisans end up as collateral damage in the war between craftsmanship and consumerism.

The irony is that while we chase the success of international fast fashion brands, these same brands are now adopting a more sustainable direction.

H&M plans to transition to 100% sustainable cotton by 2020, according to its 2018 annual report. Similarly, Zara has pledged to create collections out of 100% sustainable cottons and linens and 100% recycled polyester, with zero landfill waste from its facilities.

Even luxury brands are becoming more conscious, with Gucci's creative director Alessandro Michele taking to his instagram to announce that they will be doing two shows per year rather than five. And Michele is not the only one.

In his open letter to fashion-industry trade journal WWD, Giorgio Armani urges us to "slow everything down, to realign everything, to draw a more authentic and true horizon. No more spectacularisation, no more waste."

He further says that, "The moment we are going through is turbulent, but it offers us the unique opportunity to fix what is wrong, to remove the superfluous, to find a more human dimension"

Only time will tell if changes in the international fashion fraternity are motivated by authenticity and the greater good or if its just prudent decision-making based on consumer trends and the predicted recession.

But something needs to change.

Ideally, every fashion brand would produce eco-friendly garments made by people who are treated with respect and paid fair wages. However, the prices of ethically produced garments often end up being too steep for the average consumer.

The 2019 Nosto Sustainability in Fashion Retail survey found that "over half (52%) of consumers in the UK and US want the fashion industry to become more sustainable, with calls for reduced packaging and fair pay for workers among their top demands. But only 29% of these consumers say they will pay more for sustainably-made versions of the same items."

In order for slow fashion to become part of the mainstream, the government as well as the local fashion industry will need to be part of this shift in strategy. Our brands need to do more than just make 'eco-friendly' bags once a year. If they want to be on the right side of history, they must develop sustainable policies that can be implemented across product development, supply chain, and human resource management.

We are all aware that the old normal doesnt exist anymore, and in its place we are left with crumbling older systems. This may be the perfect time to build a newer, better normal.

But will the local audience agree to it?

Waqar believes that internationally things have been changing since a while, and will continue to change.

"The local market will be slower," he says. "Local consumers dont have much for entertainment other than shopping. If people stop buying less it will be due to the oncoming recession, rather than a shift towards sustainability."

Amaneh thinks along similar lines. She says that instead of four to five collections per season, she will have less as due to the recession consumers will not have the capacity to buy so much.

"The market forces are going to force everybody to slow down," she adds.

Ultimately, every kind of progress takes time, and while Covid-19 has become a massive hindrance to our way of life, it has also forced us to rethink our priorities. It will take a thorough systematic change for the fledgling sustainable fashion industry in Pakistan to survive in the long run. Until then, it's up to us to decide if we are willing to pay the true cost of what we wear.

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Sustainable fashion in the aftermath of Covid-19 - Prism - DAWN.COM - DAWN.com

mTOR and the Science of Aging and Chronic Disease – The Doctor Weighs In

What if you could age slower and maintain your ability to be active and enjoy your family well into your 70s or 80s or beyond? What if you could delay the onset of chronic disease by almost a decade? Well, that is no longer a dream. Thanks to advances in the science of aging and chronic disease, we know that there are things that you can do now to impact your health and, perhaps, your longevity.

Lets start our discussion by diving into some of the basic science related to prolongation of a healthy lifespan. Dont worry, we are going to start with a video and its going to be fun.

First, check out this very entertaining short TED talk by Cynthia Kenyon who is a top scientist at the University of California at San Francisco Medical School. Then come back to this post for an expanded discussion.

The importance of Dr. Kenyons work and that of contemporary aging researchers is that they showed, for the first time, that aging and age-related chronic diseases arent things that just happen to us. [1] They are, in fact, related to an evolutionarily-conserved complex, highly regulated, and interconnected series of biochemical pathways.

Central to these pathways is a molecule called mTOR which stands for mechanistic Target of Rapamycin. It is so-named because rapamycin, a naturally occurring substance, inhibits the many of the activities of mTOR triggering a variety of metabolic and clinical outcomes. The most well-known of which is the extension of healthy lifespan.[2, 3]

mTOR exists as a complex of proteins called mTOR complex or mTORC. There are actually two different forms mTORC known as mTORC1 and mTORC2. Activation of the complexes occurs via different pathways. Once activated the mTOR complexes, in turn, activate or inhibit pathways critical to cell function. [2, 3]

mTORC1 and 2 are activated or inactivated depending on the availability of nutrients in the cells environment (e.g., glucose, amino acids and various growth factors). In fact, you can think of mTORC as integrating and responding to the energy status of the cells environment.

When times are good and energy, oxygen, nutrients, and growth factors is plentiful, mTORC1 is activated and stimulates metabolic pathways that lead to growth. When times are tough, those pathways are suppressed and the pathways related to survival are activated.

Here are some of the cellular functions mTORC1 regulates [2,4]:

The last two functions are inhibited when energy, nutrients, and growth factors are plentiful.

mTORC2 is activated by insulin and growth factors. [2,4] It regulates the following:

Rapamycin inhibits most but not all of the activities of mTORC1. However, it does not inhibit mTORC2 in the short run. There is some evidence that chronic administration of rapamycin, however, can inhibit mTORC2.[4] Further, there are important feedback pathways between mTORC1 and mTORC2.

Living organisms on our planet are subject to varying availability of nutrients and other sources of energy. In order to survive, they must be able to sample the energy availability in their surroundings and adjust accordingly.

mTOR-linked pathways provide that mechanism. Receptors found in cell membranes have both an external-facing component and an internal-facing component. The external component binds to nutrients, such as glucose, amino acids, oxygen, and various growth factors. As described above, this leads to the activation or inactivation of different intermediate proteins that ultimately activate or inhibit mTOR.

For example, during times of energetic stress, a protein known as AMPK is activated. This in turn inhibits mTORC1 and leads to activation or inhibition of other intermediate compounds. The result is a state of cellular activity that favors prolongation of lifespan.[5]

Although the pathways are incompletely understood, it is of note that dietary restriction a self-induced famine in a way is also associated with longevity.[5] We must remember, though, because of complex feedback loops, the ability to prolong lifespan via these mechanisms is not limitless.

On the other hand, during times of plenty, the availability of glucose increases. In addition to reducing the activation of AMPK, it also triggers the release of the hormone insulin and insulin-like growth factor). This leads to mTOR activation and creation of a state that favors growth and development including such things as elevated lipid levels that favor the development of chronic diseases.

Understanding the molecular biology of the mTOR pathways has some very practical applications. For example, as we have already pointed out, restricting calories is associated with reduced levels of some factors that inhibit mTORC1 and is associated with lifespan extension.[5] Intermittent fastingand exercise also reduce mTOR activity.

Also, restricting carbohydrates in people with Type 2 diabetes is known to lower blood glucose, insulin, and IGF-1 levels. The benefits of this type of diet does not require weight loss, although many do lose weight with carbohydrate restriction. [6] In fact, some experts have called for dietary carbohydrate restriction to be the first intervention prescribed in diabetes management. [6]

The prevailing American high-carbohydrate, high-fat fast-food diet, on the other hand, drives extra calorie intake and as well as higher levels of the factors that activate mTORC1. This, unfortunately, leads to metabolic conditions that accelerate the development of chronic diseases such as diabetes and heart artery problems.[6]

Metformin is the most commonly prescribed drug for Type 2 diabetes. It interferes with the same signaling pathways that we have been discussing. Specifically, it leads to the reduction of glucose, IGF-1, insulin levels. This, in turn, leads to inhibition of mTORC1. This results in a metabolic state that favors important health outcomes, such as:

Further, the drug has been proven to be safe with relatively few serious side effects. And, it is cheap, making it accessible even for people without health insurance.

Metformin is the also first drug approved by the FDA to enter a clinical trial to assess its effect on prolongation of a healthy lifespan. According to American Association for Aging Research, the Targeting Aging with Metformin (TAME) trials are a series of nationwide, six-year clinical trials at 14 leading research institutions across the country that will engage over 3,000 individuals between the ages of 65-79.

These trials will test whether those taking metformin experience delayed development or progression of age-related chronic diseasessuch as heart disease, cancer, and dementia.

As mentioned, the drug rapamycin inhibits mTORC1 activity and is associated with a prolonged lifespan. However, systemic rapamycin has unacceptable side effects, so its use is limited in humans.

It is used, however, for local applications. One example is the use of Sirolimus (the brand name of rapamycin) in early versions of drug-eluting stents (DES) used to treat coronary artery disease. [7]

More recently, scientists have modified rapamycin to create less toxic forms of the drug. They are known as rapalogs. These include everolimus, zotarolimus, and biolimus. Together with improved stent platform materials, the use of these DESs have been shown to lower thrombotic events related to the stents. [8]

There are a number of drugs that are used for cardiovascular disease that specifically impact the mTORC pathways by various mechanisms. For example, lisinopril (ACE inhibitor), losartan (angiotensin receptor blocker), atorvastatin (statin), and eplerenone (mineralocorticoid receptor blocker) all reduce oxidative particle formation. Indirectly, this lead to the inhibition of mTORC.

This, as we know, leads to metabolic changes that favor healthy aging. These effects on the mTOR-related signaling pathways may be the reason why these medications lower the risk of heart attack and stroke more than they reduce the target risk factors of blood pressure, lipid, and glucose levels.

On the other hand, tobacco smoke increases oxidative stress and favors the activation of mTORC pathways. This may eventually lead to Chronic Obstructive Lung Disease (COPD) and lung cancer.

Interfering with this core signaling is a form of precision medicine that impacts the molecular biology that causes cardiovascular disease, cancer, and accelerated aging. These medications are antioxidants that work.

Here is the most shocking insight. The same core signaling that causes accelerated aging, chronic disease, and ultimately death is essential to produce a perfectly developed newborn. At the moment of conception, there is a single cell that will ultimately become all the cells in the body with their vastly different functions.

The DNA for every cell in your body is the same. Epigenetic regulation determines which genes are turned on or off in a particular cell type. For example, normal EGFR function is necessary to establish pregnancy successfully at the very beginning of life. However, it contributes to chronic disease development later.

Angiotensin II is required to form a normal fetal kidney, but inappropriate activation later in life contributes to developing hypertension, chronic kidney disease, and congestive heart failure.

mTOR activation via nutrient sensing and growth factor signaling in the fetus directs a master symphony of switching genes on in just the right place, at just the right time, with just the right intensity for an exact amount of time to produce a perfect infant.

However, the same genes that are essential to coordinate normal development cause disease and death with chaotic activation later.

The human genome project did not give us the answers for accelerated aging and common chronic diseases. These problems are caused by normal genes that are inappropriately switched on later in life by things like aging, unhealthy diets, and tobacco smoke.

Specific highly effective generic medications with few side effects can block the signaling from those genes and lead to dramatically better clinical outcomes at a lower cost. Caloric restriction, intermittent fasting, exercise, and the specific medications mentioned all impact the same signaling.

New science, new systems, and new payment models can improve our health at a lower cost. All the necessary elements are available. It is time to bring the stakeholders together and get started.

2. Papadopoli D, Boulay K, Kazak L, et al. mTOR as a central regulator of lifespan and aging [version 1; peer-review: 3 approved] latest versions as of 07/27/20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611156/pdf/f1000research-8-18802.pdf

3. Weichhart T. mTOR as regulator of lifespan, aging and cellular senescence. Gerontology. (2018) 64(2):127-134.

4. Samidurai A, Kukreja R, Das A. Emerging role of mTOR signaling-related miRNAs in cardiovascular diseases. Oxidative Medicine and Cellular Longevity. Volume 2018, Article II6141902, 23 pages https//:doi.org/10.1155/2018/6141902.

5. Longo V, Antebi A, Bartke A, et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell (2015) 14, 497-510.

6. Feinman R, Pogozelski W, Astrup, A, et al. Dietary carbohydrate restriction as the f first approach in diabetes management: Critical review and evidence base. Nutrition(2015) 31:1-13.

7. Serruys P, Regar E, Carter A. Rapamycin eluting stent: the onset of a new era in interventional cardiology.Heart(2002) 87:305-305.

8. Im E, Hong, M-K. Drug-eluting stents to prevent stent thrombosis and restenosis (2016) 14(1):87-104

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mTOR and the Science of Aging and Chronic Disease - The Doctor Weighs In

The genetic basis of bats superpowers revealed – YubaNet

July 23, 2020 For the first time, the raw genetic material that codes for bats unique adaptations and superpowers such as the ability to fly, to use sound to move effortlessly in complete darkness, to survive and tolerate deadly diseases, to resist ageing and cancer has been fully revealed.

Bat1K (Bat1K.com), a global consortium of scientists dedicated to sequencing the genomes of every one of the 1421 living bat species, has generated and analyzed six highly accurate bat genomes that are ten times more complete than any bat genome published to date, in order to uncover bats unique traits.

Given these exquisite bat genomes, we can now better understand how bats tolerate viruses, slow down ageing, and have evolved flight and echolocation. These genomes are the tools needed to identify the genetic solutions evolved in bats that ultimately could be harnessed to alleviate human ageing and disease, Emma Teeling, University College Dublin, Co-Founding Director of Bat1K and Senior Author.

To generate these exquisite bat genomes, the team used the newest technologies of the DRESDEN-concept Genome Center, a shared technology resource in Dresden, to sequence the bats DNA, and generated new methods to assemble these pieces into the correct order and to identify the genes present.

Using the latest DNA sequencing technologies and new computing methods for such data, we have 96 to 99 percent of each bat genome in chromosome level reconstructions an unprecedented quality akin to for example the current human genome reference which is the result of over a decade of intensive finishing efforts. As such, these bat genomes provide a superb foundation for experimentation and evolutionary studies of bats fascinating abilities and physiological properties Eugene Myers, Director of Max Planck Institute of Molecular Cell Biology and Genetics, and the Center for Systems Biology, Dresden, Germany, Senior Author.

Relationship to other mammals

The team compared these bat genomes against 42 other mammals to address the unresolved question of where bats are located within the mammalian tree of life. Using novel phylogenetic methods and comprehensive molecular data sets, the team found the strongest support for bats being most closely related to a group called Ferreuungulata that consists of carnivores (which includes dogs, cats and seals, among other species), pangolins, whales and ungulates (hooved mammals).

To uncover genomic changes that contribute to the unique adaptations found in bats, the team systematically searched for gene differences between bats and other mammals, identifying regions of the genome that have evolved differently in bats and the loss and gain of genes that may drive bats unique traits.

Our genome scans revealed changes in hearing genes that may contribute to echolocation, which bats use to hunt and navigate in complete darkness. Furthermore, we found expansions of anti-viral genes, unique selection on immune genes, and loss of genes involved in inflammation in bats. These changes may contribute to bats exceptional immunity and points to their tolerance of coronaviruses. Michael Hiller, Max Planck Research Group Leader, Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Max Planck Institute for the Physics of Complex Systems, and the Center for Systems Biology, Dresden, Senior Author.

Tolerance against viruses

The team also found evidence that bats ability to tolerate viruses is reflected in their genomes. The exquisite genomes revealed fossilised viruses, evidence of surviving past viral infections, and showed that bat genomes contained a higher diversity than other species providing a genomic record of historical tolerance to viral infection.

Given the quality of the bat genomes the team uniquely identified and experimentally validated several non-coding regulatory regions that may govern bats key evolutionary innovations.

Having such complete genomes allowed us to identify regulatory regions that control gene expression that are unique to bats. Importantly we were able to validate unique bat microRNAs in the lab to show their consequences for gene regulation. In the future we can use these genomes to understand how regulatory regions and epigenomics contributed to the extraordinary adaptations we see in bats, says Sonja Vernes, Co-Founding Director Bat 1K, Max Planck Institute for Psycholinguistics, Nijmegen, Senior Author.

This is just a beginning. The remaining ~1400 living bat species exhibit an incredible diversity in ecology, longevity, sensory perception and immunology, and numerous questions still remain regarding the genomic basis of these spectacular features. Bat1K will answer these questions as more and more exquisite bat genomes are sequenced, further uncovering the genetic basis of bats rare and wonderful superpowers.

SEE ORIGINAL STUDY: https://www.nature.com/articles/s41586-020-2486-3

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The genetic basis of bats superpowers revealed - YubaNet