Medical Breakthrough: First Test To Show Parkinson's Disease

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POSTED: 4:31 pm MST February 14, 2012

UPDATED: 4:59 pm MST February 14, 2012

LOS ANGELES -- More than one million Americans are living with Parkinson's disease. Right now, doctors diagnose it by conducting a physical exam that?s often unreliable, but that?s about to change.William used to be a professional welterweight fighter. Today, he?s fighting a different yet powerful opponent, Parkinson?s disease."I got Parkinson?s, Parkinson?s ain?t got me," William "Tank" Hill, a former boxer said. Debora Bergstrom is also battling the condition that causes tremors, balance problems and speech issues. The mom of three was diagnosed four years ago by a neurologist."She told me to stand up, walk, she rotated my arms and hands, and she said, yes, you have Parkinson's," Debora Bergstrom said.Many people wait years before getting that diagnosis. Doctors physically examine patients for the telltale symptoms to formulate their conclusion, but their observations aren?t always accurate.Forty percent of Parkinson?s patients are undiagnosed and at least 10 percent who are diagnosed don?t really have it. Doctor Louise Thomson says a new imaging test called DATscan is giving doctors a glimpse inside the Parkinson?s brain. First, doctors inject patients with a tracer. Then they scan the brain for dopamine, a chemical that Parkinson?s patients lack.Thomson says the test can tell doctors if the patient has Parkinson?s or just a tremor disorder, which is treated differently"This is a game changer. It?s going to lead to earlier diagnosis and clearer diagnosis for patients with tremors," Doctor Louise Thomson, MBChB, from Cedars-Sinai Medical Center explained.An earlier diagnosis means patients can start treatments sooner, potentially slowing symptom development of this devastating disease. For William and Debora, every symptom-free day matters. Now , doctors are one step closer to figuring that out. The following are comments from our users. Opinions expressed are neither created nor endorsed by TheDenverChannel.com. By posting a comment you agree to accept our Terms of Use. Comments are moderated by the community. To report an offensive or otherwise inappropriate comment, click the "Flag" link that appears beneath that comment. Comments that are flagged by a set number of users will be automatically removed.

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Medical Breakthrough: First Test To Show Parkinson's Disease

LSVT® LOUD Treatment Benefits Parkinson's Disease Patient — Hendricks Regional Health – Video

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31-10-2011 14:20 Nearly 90 percent of patients with Parkinson's Disease (PD) have speech problems that start early in the disease process and progressively worsen. These speech problems can make it difficult for patients to be heard or understood by others, affecting their quality of life. Hendricks Regional Health offers LSVT®LOUD, an innovative treatment protocol that has been proven to improve voice and speech in individuals with PD. The program, offered by our speech therapy team, is recommended for virtually any patient with PD. Patient Ed Burns recently had great success improving his communication skills throughout the course of treatment. Burns works as a call-center representative, so his voice is his livelihood. Hear how this program has made a great difference in his life.

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LSVT® LOUD Treatment Benefits Parkinson's Disease Patient -- Hendricks Regional Health - Video

Parkinson's Disease: Study of Live Human Neurons Reveals the Disease's Genetic Origins, New Drug Targets

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News Release

UB's Feng says the use of iPSCs was "a game-changer for Parkinson's disease. It finally allowed us to obtain the material we needed to study this disease."

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Release Date: February 7, 2012

Summary:

-- UB researchers have discovered how mutations in parkin disrupt proper function of dopamine, the neurotransmitter that controls body movement.

-- They found that parkin mutations disrupt the precise actions of dopamine and produce more free radicals, which in turn destroy the dopamine neurons, leading to Parkinson's disease.

-- This is the first study to use live human neurons to investigate what role parkin plays in Parkinson's disease; this dramatic advance was made possible by the use of induced pluripotent stem cells.

-- Funding was provided by the Michael J. Fox Foundation for Parkinson's Research; the National Institutes of Health; SUNY REACH, a research network of SUNY academic medical centers; and NYSTEM, New York State's stem cell initiative.

BUFFALO, N.Y. -- Parkinson's disease researchers at the University at Buffalo have discovered how mutations in the parkin gene cause the disease, which afflicts at least 500,000 Americans and for which there is no cure.

The results are published in the current issue of Nature Communications.

The UB findings reveal potential new drug targets for the disease as well as a screening platform for discovering new treatments that might mimic the protective functions of parkin. UB has applied for patent protection on the screening platform.

"This is the first time that human dopamine neurons have ever been generated from Parkinson's disease patients with parkin mutations," says Jian Feng, PhD, professor of physiology and biophysics in the UB School of Medicine and Biomedical Sciences and the study's lead author.

As the first study of human neurons affected by parkin, the UB research overcomes a major roadblock in research on Parkinson's disease and on neurological diseases in general.

The problem has been that human neurons live in a complex network in the brain and thus are off-limits to invasive studies, Feng explains.

"Before this, we didn't even think about being able to study the disease in human neurons," he says. "The brain is so fully integrated. It's impossible to obtain live human neurons to study."

But studying human neurons is critical in Parkinson's disease, Feng explains, because animal models that lack the parkin gene do not develop the disease; thus, human neurons are thought to have "unique vulnerabilities."

"Our large brains may use more dopamine to support the neural computation needed for bipedal movement, compared to quadrupedal movement of almost all other animals," he says.

Since in 2007, when Japanese researchers announced they had converted human cells to induced pluripotent stem cells (iPSCs) that could then be converted to nearly any cells in the body, mimicking embryonic stem cells, Feng and his UB colleagues saw their enormous potential. They have been working on it ever since.

"This new technology was a game-changer for Parkinson's disease and for other neurological diseases," says Feng. "It finally allowed us to obtain the material we needed to study this disease."

The current paper is the fruition of the UB team's ability to "reverse engineer" human neurons from human skin cells taken from four subjects: two with a rare type of Parkinson's disease in which the parkin mutation is the cause of their disease and two healthy subjects who served as controls.

"Once parkin is mutated, it can no longer precisely control the action of dopamine, which supports the neural computation required for our movement," says Feng.

The UB team also found that parkin mutations prevent it from tightly controlling the production of monoamine oxidase (MAO), which catalyzes dopamine oxidation.

"Normally, parkin makes sure that MAO, which can be toxic, is expressed at a very low level so that dopamine oxidation is under control," Feng explains. "But we found that when parkin is mutated, that regulation is gone, so MAO is expressed at a much higher level. The nerve cells from our Parkinson's patients had much higher levels of MAO expression than those from our controls. We suggest in our study that it might be possible to design a new class of drugs that would dial down the expression level of MAO."

He notes that one of the drugs currently used to treat Parkinson's disease inhibits the enzymatic activity of MAO and has been shown in clinical trials to slow down the progression of the disease.

Parkinson's disease is caused by the death of dopamine neurons. In the vast majority of cases, the reason for this is unknown, Feng explains. But in 10 percent of Parkinson's cases, the disease is caused by mutations of genes, such as parkin: the subjects with Parkinson's in the UB study had this rare form of the disease.

"We found that a key reason for the death of dopamine neurons is oxidative stress due to the overproduction of MAO," explains Feng. "But before the death of the neurons, the precise action of dopamine in supporting neural computation is disrupted by parkin mutations. This paper provides the first clues about what the parkin gene is doing in healthy controls and what it fails to achieve in Parkinson's patients."

He noted in this study that these defects are reversed by delivering the normal parkin gene into the patients' neurons, thus offering hope that these neurons may be used as a screening platform for discovering new drug candidates that could mimic the protective functions of parkin and potentially even lead to a cure for Parkinson's.

While the parkin mutations are only responsible for a small percentage of Parkinson's cases, Feng notes that understanding how parkin works is relevant to all Parkinson's patients. His ongoing research on sporadic Parkinson's disease, in which the cause is unknown, also points to the same direction.

In addition to Feng, co-authors are Houbo Jiang, PhD, Yong Ren, PhD, Eunice Y. Yuen, all research assistant professors at UB; Ping Zhong, PhD, research scientist, Mahboobe Ghaedi, PhD, postdoctoral associate, Zhixing Hu, PhD, postdoctoral associate, and Zhen Yan, PhD, professor, all of the UB Department of Physiology and Biophysics. Other co-authors are Gissou Azabdaftari, MD, of the Roswell Park Cancer Institute, and Kazuhiro Nakaso, MD, of Tottori University in Japan.

The University at Buffalo is a premier research-intensive public university, the largest and most comprehensive campus in the State University of New York. UB's more than 28,000 students pursue their academic interests through more than 300 undergraduate, graduate and professional degree programs. Founded in 1846, the University at Buffalo is a member of the Association of American Universities.

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Parkinson's Disease: Study of Live Human Neurons Reveals the Disease's Genetic Origins, New Drug Targets

Multiple sclerosis (MS) – Better Health Channel

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Multiple sclerosis (MS) is the most common chronic disease of the central nervous system among young Australians. Victoria has more people with MS than any other state in Australia. MS is not contagious, but it is progressive and unpredictable.

MS occurs when the protective sheath (myelin) around the nerve fibres in the brain and spinal cord becomes damaged, causing random patches called plaques or lesions. These patches distort and interrupt the messages that are sent along these nerves. Sclerosis means scarring and the disease is labelled multiple because the damage usually occurs at a number of points.

There are many different health effects of this disease and no two people will share the same symptoms. The cause of MS is unknown and, as yet, there is no cure. However, treatments are available to ease symptoms and slow down the course of the disease.

The different types of MS are:

The progressive form of MS is characterised by a steady worsening of symptoms without any remissions. The symptoms can be any combination of the five major health problems of MS, including:

The trigger to the disease has not yet been discovered, but it is thought that genetic and environmental factors are involved. Research so far has found that, in nearly two thirds of cases, a relapse has been preceded by a viral illness.

Some of the medication treatments available include:

Some alternative therapies that may be helpful include:

This page has been produced in consultation with and approved by: MS Australia

Last updated: August 2014

Content on this website is provided for education and information purposes only. Information about a therapy, service, product or treatment does not imply endorsement and is not intended to replace advice from your doctor or other registered health professional. Content has been prepared for Victorian residents and wider Australian audiences, and was accurate at the time of publication. Readers should note that, over time, currency and completeness of the information may change. All users are urged to always seek advice from a registered health care professional for diagnosis and answers to their medical questions.

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Multiple sclerosis (MS) - Better Health Channel

Multiple Sclerosis and Mobility Scooters

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What is Multiple Sclerosis?

Multiple Sclerosis is an autoimmune disorder and neurological condition, most commonly diagnosed between the ages of 20-40, though it can occur at younger or older ages as well. Nearly twice as many women suffer from MS as men. Most researchers now believe that genetic and environmental factors may contribute to MS, but the exact triggers of MS remain unknown.

Physical symptoms resulting from nerve inflammation and damage include difficulties with walking and balance, muscle spasms, fatigue, stiffness, and even vision impairment.

Treatments include conventional drug regimens (often including steroids), changes in diet, exercise, and sleep patterns, physiotherapy, and alternative medicine. There is no cure.

While MS patients have better treatment plans than in years past as more is understood about the disease, for a portion of those with multiple sclerosis, disability is a very real concern. And for some of those suffering with debilitating symptoms of MS, one option can be a mobility scooter.

Lifestyle Adaptations

For those with multiple sclerosis who can no longer consistently or ably walk or otherwise ambulate, mobility scooters can be a way to limit the way the disease impacts their daily life. Given how MS can limit their ability to live independently, as well as take away control in their daily lives, mobility scooters can help give some of that power back.

This is especially true for those suffering with mobility issues, as a scooter can help them continue an otherwise normal routine, thus giving back some semblance of freedom, independence, and even dignity.

It may not need to be an all the time thing, either. For some MS patients, a mobility scooter may only occasionally be needed, such as on days when they are especially fatigued or especially unsteady on their feet. For other patients, it may be a near constant aid. At either end of the mobility spectrum, however, scooters can help patients live their lives.

Additional Features

Different features of various scooter designs can help, too.

For instance, some scooters may offer swivel seats, which may make it easier for patients to get in and out of the scooter. Adjustable seats and arm rests are other ways in which scooters can help support function, and scooters that offer delta handlebars may help alleviate pressure points or even allow operation with either hand, which can come in handy for patients who may have one side of their body more affected than the other.

Similarly, some scooters can be packed down with a single hand, allowing for much easier transport in a vehicle, for instance.

For those patients who need more support, three- and four-wheel scooters can provide additional stability.

Fortunately, as doctors and researchers come to understand MS and MS treatment better, fewer MS patients have the same kinds of mobility concerns, or needs for scooters. For those who can benefit from a scooter in their life, however, the advantages can be many, and odds are good they can find a scooter with whatever features or modifications they need to live a more independent life than they otherwise might be able.

Even for patients who might normally have good mobility, the cost of many scooters is such that they may be worth having as part of a treatment plan for those days when they are feeling unsteady, or could otherwise use a little more support and stability in their movements.

Mobility scooters don’t have to just be for those patients who are most limited, after all; they can be a strategy to extend function no matter how a MS patient is affected.

As a result, if you or a family member or friend suffers from MS, you should definitely consider the ways in which a mobility scooter might help improve quality of life, making more possible with less effort.

After all, while MS doesn’t yet have a cure, there’s no reason you or others can’t still live the life you want while still managing your symptoms and treatments!

Multiple Sclerosis – An infographic by MS

 

 

Multiple sclerosis – NHS Choices

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Introduction

Multiple sclerosis (MS) affectsnerves in the brain and spinal cord, causing a wide range of symptoms including problems with muscle movement, balance and vision.

Each nerve fibre in the brain and spinal cord is surrounded by a layer of protein called myelin, which protects the nerve and helps electrical signals from the braintravel to the rest of the body. In MS, the myelin becomes damaged.

This disrupts the transfer of these nerve signals, causing a wide range of potential symptoms, such as:

Read more about the symptoms of multiple sclerosis.

Around eight out of 10 people with MS are diagnosed with the relapsing remitting type of MS.

Someone with relapsing remitting MS will have flare-ups of symptoms, known as relapses. These can last from a few days to a few months.

These will be followed by periods where symptoms are mild or disappear altogether. This is known as remission and can last for days, weeks or sometimes months.

Usually after around 15 years, around half of people with relapsing remitting MS will go on to develop secondary progressive MS.

In secondary progressive MS, symptoms gradually worsen over time. Some people may still have relapses, but without full recovery from symptoms.

The least common form of MS is primary progressive MS.

In this type, symptoms gradually get worse over time and there are no periods of remission.

There is currently no cure for MS, but a number of treatments can help.

Relapsing remitting MS can be treated with disease-modifying drugs. These are designed to reduce the number of relapses someone has. They may also be able to slow the progression of MS.But they are not suitable for all people with MS.

Some of these drugs can also be used for treating secondary progressive MS, if someone is still experiencing relapses.

Currently, there is no treatment that can slow the progress of primary progressive MS.

Read more about the treatment of multiple sclerosis.

MS is known as an autoimmune condition. This is where something goes wrong with the immune system (the bodys defence against infection) and it mistakenly attacks healthy body tissue in this case, the myelin covering of nerves.

This can cause multiple sections of the brain and spinal column to become damaged and hardened (sclerosis), which can disrupt the nerve signals passing through these areas.

Exactly what causes the immune system to act in this way is unclear, but most experts thinka combination of genetic and environmental factors are involved.

Read more about the possible risk factors and causes of multiple sclerosis.

It is estimated there are currently around 100,000 people with MS in the UK.

MS is most commonly diagnosed in people aged 20-40, although it can happen at any age. Children can also get MS, although this is rare.

For reasons that are unclear, MS is three timesas common in women than men, and more common in white people than black and Asian people.

MS can be a challenging and frustrating condition to live with but new treatments over the past 20 years have considerably improved the quality of life of people with the condition.

MS is not fatal, but somecomplications that can arise from severe MS, such as pneumonia, can be.

As a result, the average life expectancy for people with MS is around five to 10 years lower than the population at large. This gap appears to be getting smaller, perhaps because of improved medical care.

There are a wide range of treatments and therapies, including physiotherapy, that can help relieve symptoms and make day-to-day living easier for people with MS.

It may be useful to readyour guide to care and support written for people with care and support needs, as well as their partners and relatives. It includes information and advice on:

There are three main MS charities in the UK:

These organisations offer useful advice, publications, news items about ongoing research, blogs and chatrooms.

It is highly recommended that you visit these websites if you, or someone you know, has just been diagnosed with MS.

There is also the shift.ms website which is an online community for younger people affected by MS.

If you have multiple sclerosis you should have a flu jab every year. Find out why and how

Page last reviewed: 03/04/2014

Next review due: 03/04/2016

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Multiple sclerosis - NHS Choices

Multiple Sclerosis: Overview & Facts – WebMD

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Overview & Causes

Multiple sclerosis is a mysterious, often frustrating disease. Learn what scientists know about MS -- what seems to trigger it, and its effect on the nervous system.

What makes the bodys immune system cause damage to healthy nerves? Learn more about MS and its effect on the brain and spinal cord.

Maybe youve felt exhausted or weak lately. Or your foot is starting to tingle. So you do a quick Internet search and come up with an alarming result: Your symptom is one of thesigns of multiple sclerosis(MS), a disease of thebrainand spinal cord. Before you start to worry, know that many signs of the condition are the same as symptoms of other health problems.

Genetics, the environment, even viruses may play a role in who gets MS.

Clinically isolated syndrome (CIS) happens when your immune system attacks your nervous system. Until a few years ago, doctors told people who had one flare that they had possible MS. While CIS can develop into multiple sclerosis, that doesn't always happen.

The most comprehensive genetic study to date ofmultiple sclerosishas pinpointed a cluster of genes on chromosome 6 as playing the major role in causing the disorder.

Multiple sclerosis(MS) andamyotrophic lateral sclerosis(ALS) are different diseases with some similar features and symptoms.

Continue reading below...

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Multiple Sclerosis: Overview & Facts - WebMD

Multiple Sclerosis (MS): Check Your Symptoms and Signs

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Symptom Checker: Symptoms & Signs Index

Medical Author: Melissa Conrad Stppler, MD

Multiple sclerosis symptoms vary widely, and a description of "typical" symptoms is difficult. All the symptoms involve changes in neurologic functioning, but there are striking differences among patients in the type, severity, and frequency of these symptoms. Different disease patterns such as relapsing-remitting (RR), primary-progressive (PP), secondary-progressive (SP), and progressive-relapsing (PR) classify the condition according to the development and progression of symptoms over time. Relapsing-remitting (RR) multiple sclerosis is the most common type, in which symptoms (exacerbations of the condition) are followed by periods of time with reduced or no symptoms. These relatively symptom-free periods, known as remissions, can last for days or for many years.

Some cases of multiple sclerosis are so mild that the condition is difficult to diagnose. In other cases, there is a gradual decline in functioning through the years. In very rare cases, symptoms can be so severe and rapidly progressing as to be fatal within a short time (known as malignant or fulminant MS). Symptoms can be related to one body part or may involve multiple areas of the body. They may be of short duration or may persist for a long time. Some symptoms of multiple sclerosis are mild and cause inconvenience; others may be severe and debilitating.

Visual disturbances can be the first sign of MS. The vision changes can include blurred vision, distortions, or loss of vision in one eye. The vision symptoms can be accompanied by eye pain. Other symptoms can include tingling, numbness, prickling pain, or muscle spasms in the arms and legs that may occur at one or multiple sites. Weakness in the arm and leg muscles may occur, and this can sometimes affect balance and posture, causing clumsiness or lack of coordination. Other symptoms include fatigue, dizziness, difficulties with speech, tremors, heat intolerance, and loss of sensation. Sexual dysfunction and loss of bladder or bowel control can develop in more serious cases.

Mental changes can also occur as symptoms of multiple sclerosis. Memory loss, decreased ability to concentrate, attention deficits, an inability to perform sequential tasks, and changes in judgment have all been reported. Depression, mania, paranoia, and uncontrollable urges to laugh or weep are other symptoms that have been described.

Summary of Common MS Symptoms by MedicineNet Staff A review of our Patient Comments indicated that many people with multiple sclerosis (MS) have similar symptoms. Many patients said that they were in their 40s when their symptoms began. Optic neuritis was often the first MS symptom that people experienced. Initial symptoms also included numbness in the arms, feet, hands, and face, coupled with fatigue, dizziness, and difficulty walking. Several people also reported losing their balance and falling down, while others mentioned feeling a prickly heat sensation in their legs. Read on to learn more about MS symptoms in our Patient Comments.

Medically Reviewed by a Doctor on 4/8/2015

REFERENCE:

Luzzio, Christopher. "Multiple Sclerosis." Medscape.com. Nov. 24, 2014. <http://emedicine.medscape.com/article/1146199-overview>.

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Multiple Sclerosis (MS): Check Your Symptoms and Signs

Multiple Sclerosis Pictures: MS Brain Lesions, Symptoms …

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What Is Multiple Sclerosis (MS)?

MS is a chronic disease that damages the nerves in the spinal cord and brain, as well as the optic nerves. Sclerosis means scarring, and people with MS develop multiple areas of scar tissue in response to the nerve damage. Depending on where the damage occurs, symptoms may include problems with muscle control, balance, vision, or speech.

Nerve damage can cause:

These symptoms may lead to frequent tripping or difficulty walking.

More than half of people with MS experience a vision problem called optic neuritis. This inflammation of the optic nerve may cause blurred vision, loss of color vision, eye pain, or blindness, usually in one eye. The problem is usually temporary and tends to improve within a few weeks. In many cases, vision problems are the first sign of MS.

Although less common than vision problems, some people with MS develop slurred speech. This happens when MS damages the nerves that carry speech signals from the brain. Some people also have trouble swallowing.

MS can take a toll on mental sharpness. Some people may find it takes longer to solve problems. Others may have mild memory loss or trouble concentrating. Most people with MS also experience some loss of bladder control, because signals between the brain and bladder are interrupted. Finally, fatigue is a common problem. You may feel tired even after a good night's sleep.

Confusion, slurred speech, and muscle weakness can be symptoms of MS, but they can also be signs of a stroke. Anyone who suddenly has trouble speaking or moving his or her limbs should be taken to the ER immediately. Treating a stroke within the first few hours provides the best odds of a successful recovery.

In people with MS, the body's own immune system attacks the tissue surrounding the nerve fibers in the brain, spinal cord, and optic nerves. This covering is made of a fatty substance called myelin. It insulates the nerves and helps them send electrical signals that control movement, speech, and other functions. When myelin is destroyed, scar tissue forms, and nerve messages are not transmitted properly.

The roots of MS remain mysterious, but doctors see some surprising trends. It's most common in regions far from the equator, including Scandinavia and other parts of Northern Europe. These areas get less sunlight, so some researchers believe that vitamin D (the "sunshine vitamin") may be involved. Research suggests a possible link between vitamin D deficiency and autoimmune disorders, but studies are ongoing. Genetics appear to play a role, as well.

MS is at least twice as common in women as it is in men. While it can strike people of any race, Caucasians appear to be most at risk. The chances of developing the condition are highest between ages 20 and 50.

Tests are often used, along with a medical history and neurological exam, to diagnose MS and rule out other causes of symptoms. More than 90% of people with MS have scar tissue that shows up on an MRI scan. A spinal tap can check for abnormalities in the fluid that bathes the brain and spinal cord. Tests to look at electrical activity of nerves can also help with diagnosis. Lab tests can help rule out other autoimmune conditions or infections such as HIV or Lyme disease.

MS is different in every person. Doctors usually see four forms:

Relapsing-remitting: Symptoms flare during acute attacks, then improve nearly completely or "remit." This is the most common form of MS.

Primary-progressive: MS slowly but steadily worsens.

Secondary-progressive: Begins as relapsing-remitting type, then becomes progressive.

Progressive-relapsing: The underlying disease steadily worsens. The patient has acute relapses, which may or may not remit. This is the least common form of MS.

Research suggests that the disease may be more active during the summer months. Heat and high humidity may also temporarily worsen symptoms. Very cold temperatures and sudden changes in temperature may aggravate symptoms, as well.

While there is no cure for MS, there are "disease-modifying drugs" that can reduce the frequency and severity of MS attacks. Use can result in less damage to the brain and spinal cord over time, slowing the progression of disability. When an attack does occur, high-dose corticosteroids can help cut it short. Many drugs are also available to manage troubling MS symptoms, such as muscle spasms, incontinence, and pain.

About half of people with MS develop some form of pain, either as a result of a short circuit in the nervous system or because of muscle spasms or strain. Doctors may prescribe antidepressants and anticonvulsant medications to ease nerve pain. Pain medicines and anti-spasm drugs may also be used. Muscle pain often responds well to massage and physical therapy. Be sure to discuss the options with your doctor if you find yourself in pain.

If MS affects balance, coordination, or muscle strength, you can learn to compensate. Physical therapy can help strengthen muscles, combat stiffness, and get around more easily. Occupational therapy can help retain coordination in your hands for dressing and writing. And if you're having trouble speaking or swallowing, a speech therapist can help.

Many nontraditional therapies for MS have not been well studied. Some people say acupuncture relieves symptoms such as muscle spasms and pain, but research to confirm its value isn't conclusive. Others have reported benefits from injections of bee venom, but a rigorous study, lasting 24 weeks, showed no improvements in disability, fatigue, or the number of MS attacks. It's important to inform your doctor about any supplements, special diets, or other therapies you want to try.

Doctors generally agree that its safe for women with MS to get pregnant. Research suggests no increased risk of complications during pregnancy. In fact, many women have fewer MS symptoms during pregnancy. High levels of hormones and proteins may suppress the immune system, reducing the odds of a new attack. It's best to talk with your doctors before pregnancy, as certain MS drugs should not be used while pregnant or nursing.In the early months after delivery, the odds for a relapse can rise.

The vast majority of people with MS are able to continue walking, though many benefit from some type of assistive device. Orthotic shoe inserts or leg braces can help increase stability. When one leg is stronger than the other, a cane can help. People with significant problems with their legs may need to use a walker. And a wheelchair or scooter may be best for those who are very unsteady or tire easily.

Making a few changes around the home can help you manage daily activities on your own. Install grab bars inside and outside the shower or tub. Use a non-slip mat. Add an elevated seat and safety rails to the toilet. Lower one of your kitchen counters so you can reach it from a sitting position. And get rid of any throw rugs, which are a tripping hazard.

Exercise can ease stiffness, fatigue, and other symptoms of MS. But overdoing it could make things worse. It's best to start slowly. Try exercising for 10 minutes at a time, then gradually working your way up to a longer session. Before you begin, check with your
doctor about what type of activity and level of intensity would be most appropriate. A few possibilities include water aerobics, swimming, tai chi, and yoga.

Most people with MS live a normal or near-normal lifespan. While the condition may make it more difficult to get around or complete certain tasks, it doesn't always lead to severe disability. Thanks to effective medications, rehab therapies, and assistive devices, many people with MS remain active, stay in their jobs, and continue to enjoy their families and favorite activities.

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Multiple Sclerosis Pictures: MS Brain Lesions, Symptoms ...

Multiple Sclerosis – National Library of Medicine – PubMed …

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Evidence reviews Treatment of seizures for patients with multiple sclerosis

Epileptic seizures occur in a relatively small number of patients with multiple sclerosis, but can have serious consequences. Because the cause of epileptic seizures in patients in MS may be different from that in other forms of epilepsy, it is uncertain whether patients with MS should be treated differently. We searched for studies on the treatment of epileptic seizures in patients with MS, but found none. Well designed studies that address this issue are needed.

Multiple sclerosis (MS) is a chronic disease of the nervous system which affects young and middleaged adults. Repeated damage to parts of the nerves leads to progressive weakness and disability. Hyperbaric oxygen therapy (HBOT) involves people breathing pure oxygen in a specially designed chamber (such as used for deep sea divers suffering pressure problems after resurfacing). HBOT is sometimes used for MS in case a lack of oxygen to the affected nerves may be making MS worse, but this theory is unproven. The review of nine trials found no consistent evidence that HOBT can improve disability or modify the progression of MS. There is little need for further research.

Multiple sclerosis (MS) is a chronic disease of the nervous system which affects young and middleaged adults. Spasticity, a common problem in people with MS, is a disorder of voluntary movement caused by damage to the central nervous system. The main sign is the resistance to passive movement of a limb but other associated features pain, spasms, loss of function affect people's quality of life more directly.

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How do disease-modifying drugs compare in multiple sclerosis?

Dimethyl fumarate (trade name: Tecfidera) has been approved in Germany since January 2014 for adults with relapsing remitting multiple sclerosis.

Epileptic seizures occur in a relatively small number of patients with multiple sclerosis, but can have serious consequences. Because the cause of epileptic seizures in patients in MS may be different from that in other forms of epilepsy, it is uncertain whether patients with MS should be treated differently. We searched for studies on the treatment of epileptic seizures in patients with MS, but found none. Well designed studies that address this issue are needed.

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Multiple Sclerosis - National Library of Medicine - PubMed ...

Multiple Sclerosis (MS) Overview – HealthCommunities.com

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Overview of Multiple Sclerosis

Multiple sclerosis (MS) is an inflammatory, chronic, degenerative disorder that affects nerves in the brain and spinal cord. Myelin, the fatty substance that surrounds and insulates nerves and facilitates the conduction of nerve impulses is the initial target of inflammatory destruction in multiple sclerosis.

MS is characterized by intermittent damage to myelin, called demyelination. Demyelination causes scarring and hardening (sclerosis) of nerve tissue in the spinal cord, brain and optic nerves. Demyelination slows conduction of nerve impulses, which results in weakness, numbness, pain and vision loss.

Because different nerves are affected at different times, MS symptoms often worsen (exacerbate), improve, and develop in different areas of the body. Early symptoms of the disorder may include vision changes (e.g., blurred vision, blind spots), numbness, dizziness and muscle weakness.

MS can progress steadily or cause acute attacks (exacerbations) followed by partial or complete reduction in symptoms (remission). Most patients with the disease have a normal lifespan.

MS is the most common neurological cause of debilitation in young people. According to the National Institute of Neurological Disorders and Stroke, about 250,000 - 350,000 people in the United States have been diagnosed with multiple sclerosis. Worldwide, the incidence of MS is approximately 0.1 percent. Northern Europe, the northern United States, southern Australia, and New Zealand have the highest prevalence, with more than 30 cases per 100,000 people.

MS is more common in women and in Caucasians. The average age of onset is between 20 and 40, but the disorder may develop at any age. Children of parents with MS have a higher rate of incidence (30 - 50 percent).

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Multiple sclerosis – MedlinePlus

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Multiple sclerosis (MS) is a nervous system disease that affects your brain and spinal cord. It damages the myelin sheath, the material that surrounds and protects your nerve cells. This damage slows down or blocks messages between your brain and your body, leading to the symptoms of MS. They can include

No one knows what causes MS. It may be an autoimmune disease, which happens when your immune system attacks healthy cells in your body by mistake. Multiple sclerosis affects women more than men. It often begins between the ages of 20 and 40. Usually, the disease is mild, but some people lose the ability to write, speak, or walk.

There is no single test for MS. Doctors use a medical history, physical exam, neurological exam, MRI, and other tests to diagnose it. There is no cure for MS, but medicines may slow it down and help control symptoms. Physical and occupational therapy may also help.

NIH: National Institute of Neurological Disorders and Stroke

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13 Early Signs of Multiple Sclerosis – Healthline

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A Close Look at MS Symptoms

Multiple sclerosis (MS) is a disease with unpredictable symptoms that can vary in intensity. While some people experience fatigue and numbness, severe cases of MS can cause paralysis, vision loss, and diminished brain function.

MS affects an estimated 2.3 million people worldwide. Women are affected more than twice as often as men, according to the National MS Society. Family history is also a major risk factor.

MS is a progressive autoimmune disorder. That means the system designed to keep your body healthy mistakenly attacks parts of your body that are vital to everyday function. The protective covering of nerve cells are damaged, which leads to diminished function in the brain and spinal column.

The cause of MS largely remains a mystery, even though the disease was discovered in 1868. Researchers know the nerve damage is caused by inflammation, but the cause of the inflammation is still unknown.

The most common early signs of MS are vision problems, clinically called optic neuritis. Inflammation affects the optic nerve and disrupts central vision. This can lead to blurred vision in one or both eyes, double vision, or loss of contrast or vivid colors.

You may not notice the vision problems immediately, as degeneration of clear vision can be slow. Pain when you look up or to one side also can accompany vision loss.

MS affects nerves in the brain and spinal column (the bodys message center). This means it can send conflicting signals around the body. Sometimes, no signals are sent. This results in the most common symptom: numbness.

Tingling sensations and numbness are the most common warning signs of MS. Common sites of numbness include the face, arms, legs, and fingers.

Chronic pain and involuntary muscle spasms are also common with MS. One study, according to the National MS Society, showed that half of people with MS had either clinically significant pain or chronic pain.

Muscle stiffness or spasms (spasticity) are also common. They involve feelings of stiff muscles or joints as well as uncontrollable, painful jerking movements of extremities. The legs are most often affected, but back pain is also common.

Unexplained fatigue and weakness affect about 80 percent of people in the early stages of MS.

Chronic fatigue occurs when nerves deteriorate in the spinal column. Usually, the fatigue appears suddenly and lasts for weeks before improving. The weakness is most noticeable in the legs at first.

Dizziness and problems with coordination and balance can decrease the mobility of someone with MS. Your doctor may refer to these as problems with your gait. People with MS often feel lightheaded, dizzy, or feel as if their surroundings are spinning (vertigo). This symptom often occurs when a person stands up.

A dysfunctional bladder is another symptom occurring in up to 80 percent of people with MS. This can include urinating frequently, strong urges to urinate, or inability to hold in urine.

Urinary-related symptoms are often manageable. Less often, people with MS experience constipation, diarrhea, or loss of bowel control.

Sexual arousal can also be a problem for people with MS because it begins in the central nervous system where MS attacks.

About half of people with MS will develop some kind of issue with their cognitive function. This can include:

Depression and other emotional health problems are also common.

Major depression is common among people with MS. The stresses of MS can also cause irritability, mood swings, and a condition called pseudobulbar affect: bouts of uncontrollable crying and laughing.

Coping with MS symptoms, along with relationship or family issues, can make depression and other emotional disorders even more challenging.

Not everyone with MS will have the same symptoms. Different symptoms can manifest themselves during attacks. Along with the symptoms mentioned on the previous slides, MS can also cause:

MS often astounds doctors because of how much it can vary in both its severity and the ways that it affects people. Attacks can last a few weeks and then disappear. However, relapses can get progressively worse, more unpredictable, and come with different symptoms.

However, early detection may help prevent MS from progressing quickly.

MS isnt necessarily hereditary. However, you have a higher chance of developing the disease if you have a close relative with MS, according to the National MS Society.

The general population only has a tenth of a percent chance of developing MS. But the National MS Society reports that number jumps to 2.5 to 5 percent if you have a sibling or parent with MS.

Heredity isnt the only factor in determining MS. An identical twin only has a 25 percent chance of developing MS if their twin has the disease. While genetics is certainly a risk factor, its not the only one.

A doctor most likely a neurologist will perform several tests to diagnose MS, including:

Doctors use these tests to look for damage to the central nervous system in two separate areas that occurred at least one month apart. These tests are also used to rule out other conditions.

MS is a challenging disorder, but researchers have discovered many treatments that can slow its progression.

The best defense against MS is seeing your doctor immediately after you experience the first warning signs. This is especially important if someone in your immediate family has the disorder, as its one of the key risk factors for MS.

Don't hesitate. It could make all the difference.

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Multiple Sclerosis Condition Center – Health.com

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Multiple Sclerosis Journey

By Kathleen DohenyHealthDay Reporter MONDAY, Aug. 31, 2015 (HealthDay News) Breast-feeding exclusively for at least two months may help new mothers with multiple sclerosis (MS) lower their risk of relapse, new research suggests. Exclusive breast-feeding, without supplementing, seems to be key, the researchers said. We found that women with MS who breast-fed exclusively had a significantly lower [...]

By Kathleen DohenyHealthDay Reporter WEDNESDAY, Aug. 12, 2015 (HealthDay News) Children with multiple sclerosis (MS) who exercise have less disease activity than those who dont, researchers report. The study is a first look, so we cant draw any definitive conclusion from it, said study author Dr. E. Ann Yeh, director of the pediatric MS and neuroinflammatory [...]

By Dennis ThompsonHealthDay Reporter TUESDAY, June 23, 2015 (HealthDay News) Medical marijuana can be useful in treating chronic pain, but may be less effective for other conditions, a new analysis reveals. A review of nearly 80 clinical trials involving medical marijuana or marijuana-derived drugs revealed moderately strong evidence to support their use in treating chronic pain, [...]

By Dennis ThompsonHealthDay Reporter WEDNESDAY, May 27, 2015 (HealthDay News) People with multiple sclerosis may have twice the risk of dying prematurely compared to people without MS, a new study suggests. And the study also found that for people younger than 59 with MS, the risk of an early death seemed to be tripled, compared to [...]

TUESDAY, May 12, 2015 (HealthDay News) When the seasons change, your immune system response may also change, British researchers report. These findings might explain why conditions such as rheumatoid arthritis and heart disease are worse in the winter than in the summer, the new study finds. The researchers from the University of Cambridge analyzed genes from [...]

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Multiple sclerosis – Wikipedia, the free encyclopedia

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Multiple sclerosis (MS), also known as disseminated sclerosis or encephalomyelitis disseminata, is an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged. This damage disrupts the ability of parts of the nervous system to communicate, resulting in a wide range of signs and symptoms,[1][2] including physical, mental,[2] and sometimes psychiatric problems.[3] MS takes several forms, with new symptoms either occurring in isolated attacks (relapsing forms) or building up over time (progressive forms).[4] Between attacks, symptoms may disappear completely; however, permanent neurological problems often occur, especially as the disease advances.[4]

While the cause is not clear, the underlying mechanism is thought to be either destruction by the immune system or failure of the myelin-producing cells.[5] Proposed causes for this include genetics and environmental factors such as infections.[2][6] MS is usually diagnosed based on the presenting signs and symptoms and the results of supporting medical tests.

There is no known cure for multiple sclerosis. Treatments attempt to improve function after an attack and prevent new attacks.[2] Medications used to treat MS while modestly effective can have adverse effects and be poorly tolerated. Many people pursue alternative treatments, despite a lack of evidence. The long-term outcome is difficult to predict, with good outcomes more often seen in women, those who develop the disease early in life, those with a relapsing course, and those who initially experienced few attacks.[7]Life expectancy is on average 5 to 10 years lower than that of an unaffected population.[1]

Multiple sclerosis is the most common autoimmune disorder affecting the central nervous system.[8] As of 2008, between 2 and 2.5 million people are affected globally with rates varying widely in different regions of the world and among different populations.[9] In 2013, 20,000 people died from MS, up from 12,000 in 1990.[10] The disease usually begins between the ages of 20 and 50 and is twice as common in women as in men.[11] The name multiple sclerosis refers to scars (scleraebetter known as plaques or lesions) in particular in the white matter of the brain and spinal cord.[12] MS was first described in 1868 by Jean-Martin Charcot.[12] A number of new treatments and diagnostic methods are under development.

A person with MS can have almost any neurological symptom or sign; with autonomic, visual, motor, and sensory problems being the most common.[1] The specific symptoms are determined by the locations of the lesions within the nervous system, and may include loss of sensitivity or changes in sensation such as tingling, pins and needles or numbness, muscle weakness, very pronounced reflexes, muscle spasms, or difficulty in moving; difficulties with coordination and balance (ataxia); problems with speech or swallowing, visual problems (nystagmus, optic neuritis or double vision), feeling tired, acute or chronic pain, and bladder and bowel difficulties, among others.[1] Difficulties thinking and emotional problems such as depression or unstable mood are also common.[1]Uhthoff's phenomenon, a worsening of symptoms due to exposure to higher than usual temperatures, and Lhermitte's sign, an electrical sensation that runs down the back when bending the neck, are particularly characteristic of MS.[1] The main measure of disability and severity is the expanded disability status scale (EDSS), with other measures such as the multiple sclerosis functional composite being increasingly used in research.[13][14][15]

The condition begins in 85% of cases as a clinically isolated syndrome over a number of days with 45% having motor or sensory problems, 20% having optic neuritis, and 10% having symptoms related to brainstem dysfunction, while the remaining 25% have more than one of the previous difficulties.[16] The course of symptoms occurs in two main patterns initially: either as episodes of sudden worsening that last a few days to months (called relapses, exacerbations, bouts, attacks, or flare-ups) followed by improvement (85% of cases) or as a gradual worsening over time without periods of recovery (10-15% of cases).[11] A combination of these two patterns may also occur[4] or people may start in a relapsing and remitting course that then becomes progressive later on.[11] Relapses are usually not predictable, occurring without warning.[1] Exacerbations rarely occur more frequently than twice per year.[1] Some relapses, however, are preceded by common triggers and they occur more frequently during spring and summer.[17] Similarly, viral infections such as the common cold, influenza, or gastroenteritis increase their risk.[1]Stress may also trigger an attack.[18] Women with MS who become pregnant experience fewer relapses; however, during the first months after delivery the risk increases.[1] Overall, pregnancy does not seem to influence long-term disability.[1] Many events have not been found to affect relapse rates including vaccination, breast feeding,[1] physical trauma,[19] and Uhthoff's phenomenon.[17]

The cause of MS is unknown; however, it is believed to occur as a result of some combination of genetic and environmental factors such as infectious agents.[1] Theories try to combine the data into likely explanations, but none has proved definitive. While there are a number of environmental risk factors and although some are partly modifiable, further research is needed to determine whether their elimination can prevent MS.[20]

MS is more common in people who live farther from the equator, although exceptions exist.[1][21] These exceptions include ethnic groups that are at low risk far from the equator such as the Samis, Amerindians, Canadian Hutterites, New Zealand Mori,[22] and Canada's Inuit,[11] as well as groups that have a relatively high risk close to the equator such as Sardinians,[11] inland Sicilians,[23]Palestinians and Parsis.[22] The cause of this geographical pattern is not clear.[11] While the north-south gradient of incidence is decreasing,[21] as of 2010 it is still present.[11]

MS is more common in regions with northern European populations[1] and the geographic variation may simply reflect the global distribution of these high-risk populations.[11] Decreased sunlight exposure resulting in decreased vitamin D production has also been put forward as an explanation.[24][25][26] A relationship between season of birth and MS lends support to this idea, with fewer people born in the northern hemisphere in November as compared to May being affected later in life.[27] Environmental factors may play a role during childhood, with several studies finding that people who move to a different region of the world before the age of 15 acquire the new region's risk to MS. If migration takes place after age 15, however, the person retains the risk of his home country.[1][20] There is some evidence that the effect of moving may still apply to people older than 15.[1]

MS is not considered a hereditary disease; however, a number of genetic variations have been shown to increase the risk.[28] The probability is higher in relatives of an affected person, with a greater risk among those more closely related.[2] In identical twins both are affected about 30% of the time, while around 5% for non-identical twins and 2.5% of siblings are affected with a lower percentage of half-siblings.[1][2][29] If both parents are affected the risk in their children is 10 times that of the general population.[11] MS is also more c
ommon in some ethnic groups than others.[30]

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Multiple sclerosis - Wikipedia, the free encyclopedia

Multiple Sclerosis – eMedicineHealth

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Multiple Sclerosis (cont.) When to Seek Medical Care

The symptoms of multiple sclerosis are very variable and differ from patient to patient. They can also be confused with symptoms of many other conditions. A physician should be notified if you or someone you know has any of the signs and symptoms associated with multiple sclerosis. Also check with a doctor if you or someone you know has any signs or symptoms that may not be associated but that are of concern. The person may not have multiple sclerosis, but because of the nonspecific nature of this disease, it is best to let a qualified professional make that determination.

Several of the symptoms of multiple sclerosis may be severe enough to send the patient to a hospital's emergency department.

Diagnosing multiple sclerosis is difficult. The vague and nonspecific nature of this disease mimics many other diseases. Doctors combine history, physical exam, laboratory work, and sophisticated medical imaging techniques to arrive at a diagnosis.

Medically Reviewed by a Doctor on 3/12/2015

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Multiple Sclerosis – Symptoms, Causes, Treatments

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Introduction

Multiple sclerosis is a progressive autoimmune disease and the most common neurological disease diagnosed in young adults. It is believed that multiple sclerosis occurs when the bodys own immune system attacks the central nervous system. Commonly called MS, the disease generally gets worse with time and can cause significant nerve damage.

The progression and severity of multiple sclerosis varies greatly among individuals. The severity of multiple sclerosis ranges from mild to severe and disabling, and it can result in muscle weakness, loss of balance, and difficulty walking.

In some cases, multiple sclerosis can lead to serious complications, such as choking and paralysis. Early diagnosis and medical care can help manage and control symptoms and minimize complications of multiple sclerosis.

2015 Healthgrades Operating Company, Inc. All rights reserved. May not be reproduced or reprinted without permission from Healthgrades Operating Company, Inc. Use of this information is governed by the Healthgrades User Agreement.

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What is Multiple Sclerosis? Life Expectancy, Symptoms …

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Researchers believe that MS causes the body's immune system to attack myelin, which is an insulating coating around nerve cells.

When myelin erodes, communication between nerve cells in the central nervous system is disrupted. When this happens, some parts of the body do not receive instructions from the central nervous system, which controls everything the body does.

The disease can cause varying symptoms that appear with a wide range of severity, from mild discomfort to complete disability.

Learn the typical progression of MS and what to expect

Multiple sclerosis may appear in several forms. The types of MS include:

Relapsing-remitting: This form of multiple sclerosis comes and goes over time. Symptoms can be severe for a time but then disappear. About 85 percent of multiple sclerosis patients develop onset of the disease in this manner (Murray, T., et al., 2013).

Secondary-progressive: After the initial attack, the disease may begin to progress in a more deliberate way. In this type of MS, symptoms do not subside. Before new therapies were created, about 50 percent of people with multiple sclerosis entered a progressive stage. However, the effectiveness of the new therapies has not been fully evaluated (Murray T., et al, 2013).

Primary-progressive: People who develop this form of the disease generally do so later in life. They decline slowly, without many ups and downs.

Progressive relapsing: In this form of multiple sclerosis, symptoms initially progress slowly but eventually worsen over time.

Multiple sclerosis is very unpredictable. Some people have an initial attack and don't progress. Sometimes, in older people, progression will stop altogether. According to the Multiple Sclerosis Association of America, it is unclear why the disease affects people in such a variety of ways.

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