Study Links Diets High In Plant Protein To Lower Risk Of Death From All Causes Incl. Heart Disease – Green Queen Media

Researchers have found that diets high in protein, particularly plant protein, is associated with a lower risk of death from all causes. The study authors say that these findings should support recommendations to increase intake of plant proteins in the general population to improve public health.

Published in the peer-reviewed British Medical Journal on July 22, the new study finds that high intake of protein from plants such as legumes, whole grains and nuts is linked to lower risk of developing a number of diseases, including diabetes, heart disease and stroke. Meanwhile, regularly consuming red meat and other animal proteins is associated with several health problems and higher mortality rate from all causes.

Researchers from the Tehran University of Medical Sciences measured the potential dose-response relationship between consumption of total, animal and plant protein and the risk of death from all causes, cardiovascular diseases and cancer. They analysed the results of 32 studies with data on risk predictions for mortality rates in adults aged 19 and older.

These findings have important public health implications as intake of plant protein can be increased relatively easily by replacing animal protein and could have a large effect on longevity.

Mathematical models were then applied to the data to compare the effects of high and low intake of the categories of protein on mortality. In a follow-up period of over 30 years, over 113,000 deaths were recorded among the more than 715,000 participants involved.

Intake of plant proteins were associated with 8% lower risk of mortality from all causes, and a 12% lower risk of death from heart disease. The results also indicated that an additional 3% of energy derived from plant proteins daily can lower the risk of death from all causes by 5%.

The scientists say that some of the main reasons behind the trend is because plant proteins can positively affect blood pressure, cholesterol and blood sugar levels, which can in turn lower the risk of developing life-threatening diseases such as stroke.

These findings have important public health implications as intake of plant protein can be increased relatively easily by replacing animal protein and could have a large effect on longevity, said the authors of the study, adding that dietary guidelines should promote greater consumption of plant proteins.

Another study, recently published in JAMA Internal Medicine, supports the findings of this new research. Researchers from the National Cancer Institute in the U.S. found an inverse association between higher consumption of plant-based foods and heart disease mortality rates. The most prominent inverse associations were recorded in the replacement of eggs and red meat with plant proteins.

In addition to supporting human health, plant-based proteins are also more environmentally-friendly. Last year, an Oxford University study found that healthy plant-based foods were almost always associated with a smaller carbon footprint.

Lead image courtesy of iStock.

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Study Links Diets High In Plant Protein To Lower Risk Of Death From All Causes Incl. Heart Disease - Green Queen Media

Janai: The story of ‘the sacred thread’ of some Hindu men – Online Khabar (English)

Almost all Hindus across Nepal celebrate the Janai Purnima festival on the full moon day of Shrawan every year, yet many of them do not know the essence of janai, the sacred thread that gave the festival its name.

So, here we have a detail of what a janai is and why it is important in the Hindu culture.

What is a janai?

Janai, often translated as a sacred thread, is a thread that has a high religious and cultural significance among the Hindu boys and men.

According to religious texts and people who have studied it, men from Bhramin, Kshetriya and Vaishya varna (hierarchical group) receive the honour of wearing a janai during a ritual called Bratabandha (Upanayana).

Rishi Ram Pokharel, a noted Sanskrit literature scholar of the country, says this thread is normally worn diagonally, from the left shoulder to right waist, crossing the chest. In Sanskirt, a janai is called Yagyopabita. Professor Pokharel explains, Yagya refers to any kind of worship, offering, devotion, or oblation. And, Upabita means something that has to be worn while performing yagyas. Such a thread that is made holy by chanting Vedic mantras. It is believed that these mantras established several Hindu gods and goddesses in the threads.

As per Pokharel, in the Satya Yug and Treta Yug, the janai used to be of gold and during the Dwapar Yug, it used to be of silver. Coming to the final Kali Yug, it is now made up of cotton. The thread for a Brahmin consists of six thinner strands whereas, for Kshetriyas, it is three. However, some add three additional strands as a substitute to the uttariya, an upper garment, that is considered mandatory for Hindu men while performing any yagyas.

Why is it worn?

It is believed that after adorning a janai, all the gods and goddesses enter and stay in their body, mind, and soul and make their life holy and meaningful.

As the janai is given to them during the Bratabandha, it constantly reminds the wearer that they are bounded by some vows and rules, making sure that they always follow their conduct and lessons taught by their gurus.

It is also believed that this thread grants knowledge, power, prosperity, and wisdom to the bearer. Hence, whoever adorns a janai, he is always expected to be dutiful, loyal, respectful, and truthful and be in discipline.

Not only this, but it is also said the janai grants the motivation to the wearer for performing good deeds and to be in pure character. Wearing a janai is believed to grant longevity and conspicuousness. Likewise, it is also believed that adoring the janai will protect the holder against negative thoughts and energy throughout his life.

Pokharel explains whereas a janai has three, six or nine strands (as described above), a strand has three smallest units, lets say fibres. Therefore, a basic unit of the janai has nine fibres. In every fibre, there lie all Hindu deities. Omkar that symbolises all the god and goddesses and the divine power in the first, Agni (the Fire God) in the second, Naag (the Serpent God) also considered the preserver of water resources in the third, Soma (the Moon) considered as of flora in the fourth, Pitri (forefathers) who are the guides and protectors in the fifth, Prajapati refering to the creator of the world in the sixth, Vayu or Maruta (the Air God) in the seventh, Surya (the Sun) in the eighth, and Vishwadev in the ninth fibre, Pokharel says, Therefore, there is a religious belief that these gods and goddesses living in the purified janai bestow the wearer the power and strength that lies within the gods.

Also, each of the three fibres is threefold and made one strand that counts the total of three strands, symbolising the holy Trimurti or three supreme gods: Brahma (the creator), Vishnu (the preserver) and Maheshwor (the destroyer). Some even consider these three strands are symbolic of body, speech, and mind, and believe the one who adorns this holy thread gains complete control over their body, speech, and mind.

It is not only the Janai Purnima when the wearers change their janai. In the Hindu scriptures, it is mentioned that the janai should be changed in the interval of four months, before doing any yagya, or after the completion of an impure period caused by birth or death in the close family.

In the scared Smriti (Puranas), Brahma is credited for the creation of this thread; that is why it got its another name, called Brahmasutra, according to Pokharel.

Exclusive to high-caste men?

Though the practice of wearing a janai is limited to Brahmins, Kshetriyas, and Vaishyas today, an expert on religion and culture, Basudev Krishna Shastri, briefs, Everyone, including all the men and women, has the right to this. Only after adorning the janai, one is considered eligible to perform all 16 rites of human life (sanskars).

He claims all people including men and women of all castes had the tradition of wearing a janai in the past. To justify, Shastri explains, Till date, while performing any yagyas or pujas be it Durga Puja or Swasthani Puja or Laxmi Puja, we (Hindu) offer yagyopabita (janai) to the goddesses as well. Symbolically offering a janai to the female deities during a yagya connotes that they adorn the janai.

Narrating one of the sections of a Hindi book, Vedic Vangmay mein Nari (meaning Women in Vedic Literature) by Dr Sushma Shukla, Shastri briefs, In the Sutra Sahitya (Sutra Literature), Griha Sutra (text that includes information regarding Vedic domestic rituals) and in other scriptures as well, it is mentioned that a wife should wear a janai while performing any yagyas. Also, it reads those women who adorn a yagyopabita are reverent and beautiful. For him, potey that modern women wear is also a symbol of the janai.

Later, this practice faded away coming to todays world as people found it very tough to be in a strict discipline that one has to follow after wearing a janai, Shastri claims.

Gradually, people nowadays even Brahmin and Kshetriya men stopped adorning the janai as one is bounded by vow and rules after wearing it and people find it very difficult and impractical to do so.

Published on August 3rd, Monday, 2020 9:06 AM

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7 Tips To A Younger And Healthier Body In Middle Age – Longevity LIVE

Very few of us cherish the thought of growing older. Non-specific aches, pains, wrinkles, sagging skin, and additional pounds serve to slow us down and remind us that we are not immune from the effects of aging. Can we age gracefully?

A large part of how we age depends on our genetic makeup and individual gene expression that exists within our DNA. The good news is, we can slow and reduce the effects of aging with some well-planned, thoughtful action that helps keep us looking and feeling young and fresh. Is 50 the new 30? Read on to see how you can take matters into your own hands and perhaps even turn back the clock for improved youth and beauty, inside and out.

Weve all seen themthose leather heads that spend all of their time in the sun to get that healthy glow. While they may look impressively bronzed, nothing does more damage to the skin of your body than sun overexposure (1).

Sure, you can spend some time outside soaking up those rays its a good way to boost your production of vitamin D. Dont overdo it; if you must spend a day outdoors, apply a good sunblock to keep your skin young and fresh.

You are what you eat. Your body utilizes building blocks of nutrition from the food you eat, helping to facilitate all processes of cell renewal and regeneration. What are you filling your high-performance machine with?

Studies show that a diet rich in whole grains, fresh quality produce, and lean protein goes the distance and gives your body exactly what it needs to build strong, lean muscles, and healthy bones (2).

Recent studies now point to caloric excess as being a primary contributor to premature aging. Those who restrict their caloric intake while staying active can increase their lifespans by as much as 7.5 years! Learning to consciously eat will be one of the most significant things you can do to positively impact your health.

Few people drink enough watermost of us are walking around in a state of chronic dehydration. Some classic symptoms of dehydrationthat you may not even be aware of include:

Keeping your body hydrated will cause all of your bodys systems to function more efficientlyrespiration, circulation, digestion, and elimination work well, and you will feel cleaner and more energized (3). Aim for at least half your body ounces in weight daily, and youll be right on track.

You dont have to become a bodybuilder in middle age, but there is no better way to keep joints, ligaments, and bones more limber than by staying active. 30-60 minutes of moderate exercise and activity daily has the ability to boost your mental prowess, keep your weight under control, and keep you more mobile. The more you move, the better youll feel. Make some time for walking, circuit training, swimming, gardening, or cycling (4).

Even housework can be considered an activity if you commit to keeping up a moderate pace while getting household chores done. Look for opportunities in your day to boost your oxygen levels and move that body, and youll feel younger and more limber with each session.

These days, it is easy to get bogged down by the stresses and cares of life. Studies show that mismanaged stress has the ability to prematurely age both the mind and body. We need to look for ways to manage and release stress while dealing with the pressures of life.

Immersing yourself in nature, taking quiet time to read a good book that feeds the soul, or even yoga and meditation are excellent ways to release both physical and mental stress while placing you in more of a present moment awareness, where you can learn to appreciate the gifts that life has given you. Transform yourself by releasing yourself and renewing your mind.

Sleep has a tremendous impact on how we look and feel as we age. From the position that we sleep in, to the number of hours we are able to achieve in deep, restorative sleep, we can reduce fine line and wrinkle formation, balance hormones, and even protect against the development of diseases such as heart disease and diabetes. Follow these expert tips for getting improved sleep:

Youll be off to dreamland in no time!

As we age, fluctuating hormones and other naturally occurring chemicals in our body start to decline. HGH, or human growth hormone, is a substance that flows freely when we are younger, helping to strengthen bone, repair muscle tissue, and boost both collagen and metabolic processes. Growth hormone is a key anti-aging elementneeded to preserve our youth and beauty, and there are some ways to naturally boost our own production of it. Some of these factors include:

Smart supplementation of critical vitamins, minerals, and other natural treatments can increase our natural production of growth hormones, helping us to look and feel younger than our chronological age. If you do choose to use supplements as part of a total wellness plan, talk to your doctor about which ones are right for you, as well as disclose any prescription drugs you may be taking in order to rule out the possibility of interactions.

Sun damaged skin What is it? https://www.health.harvard.edu/staying-healthy/sun-damaged-skin-a-to-z

Caloric intake and Aging, Richard Weindruch, Rajindar S. Sohal,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851235/

Getting enough protein, https://www.betterhealth.vic.gov.au/health/HealthyLiving/Getting-enough-protein

Hydration Why its so important, https://familydoctor.org/hydration-why-its-so-important/

Aging well, Melinda Smith, M.A., Jeanne Segal, Ph.D., and Monika White, Ph.D.,

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7 Tips To A Younger And Healthier Body In Middle Age - Longevity LIVE

The Brutal Pleasure of Watching Charlize Theron Turn to Action – Vulture

Yes, she does her own stunts. But what makes her truly great in Mad Max: Fury Road, Atomic Blonde, and The Old Guard is her focus on the human capacity for wear and tear. Photo: J Prime/Focus Features/Kobal/Shutterstock

The first time we see Charlize Theron in Hancock, shes emerging from a suburban house in a tasteful sundress, dish towel in hand, mouth pursed in a concerned moue. Shes playing, from all appearances, a variation on The Wife that thankless figure who still toils at the sidelines of stories, periodically fretting about the choices made by the protagonist shes married to. Therons character, Mary, does indeed spend the first half of the film staring skeptically at the drunken superhero of the title, played by Will Smith, when he comes over for dinner, eventually softening enough to plead with him not to let her husband (Jason Bateman) down. But then Hancock corners Mary in the kitchen one evening and she irritatedly hurls him through a wall to bounce off the pavement of the cul-de-sac, taking the fridge along with him. Mary, it turns out, has just been playing at being a soccer mom for this lifetime. Shes an immortal being herself, and when she crashes down on Hancocks doorstep later, now dressed in black and sporting a smoky eye, the battle that ensues summons its own storm system.

Hancock, a star-driven, deconstructed-superhero oddity we really dont talk about enough, came out in 2008, the same year Iron Man ushered in an era in which franchises, rather than celebrities, became the selling point for blockbusters. It wasnt Therons first foray into action. Three years earlier, shed followed up her Oscar win for Monster by starring in on Flux, a loose adaptation of a spiky MTV animated sci-fi series that bombed in theaters. The misbegotten, studio-mangled mess put director Karyn Kusamas career on ice for years afterward, and while Therons own prospects werent as badly dinged, she still fretted that she wouldnt get a second chance at a lead action role. That part in Hancock inadvertently plays like a reaction to what happened to her 2005 film as though sneaking in under the guise of a forgettably normcore type were easier than seizing the spotlight outright.

It took Theron two decades to reach her current status as a full-blown action heroine, and she has arrived there at a time when asking audiences to invest in the pleasures of a particularly gifted performer instead of a property feels downright old-fashioned. Getting there involved significant accruing of power as a producer of her own projects as well as a performer, accompanying broader shifts in the industry, and, in general, just being very good at it. It definitely helps that shes beautiful, thin, and white, attributes the movie industry has always preferred; being able to bemoan the quality of the roles being offered to you requires that you get offered those roles in the first place. But as a star, Theron has also been canny about how she feels women get pigeonholed onscreen, repeatedly citing blunt binaries in interviews. There is a fantasy version of women in film, and they are not complex they are great mothers or fantastic whores, she said to The Scotsman in 2012.

Charlize Theron as Furiosa in Mad Max: Fury Road. Photo: Jasin Boland/Village Roadshow/Kobal/Shutterstock

When it comes to the action, theres still a strong instinct to place women in supporting roles. I got offered a lot of stuff in action movies that was either the girl behind the computer or the wife, Theron told Variety in 2017 in a piece pegged to the release of Atomic Blonde, in which she plays a tough-as-nails spy who is neither of those things and, pointedly, not an uncertain ingenue, either. Thats regular old bias, sure, but it also speaks to the limits of the industrys imagination when it comes to what women-led action looks like. When Angelina Jolie (who was once offered a Bond-girl part and famously replied that shed rather play James Bond) starred in her own espionage thriller, Salt, it was a project that had been written for a man and initially slated for Tom Cruise. While actresses like Pam Grier, Linda Hamilton, and Sigourney Weaver did pioneering work going back decades, you can still see the genre wrestling with itself and its ingrained tendency to treat femininity and action (both narratively and physically) as being at odds. One thing that has made Therons action fare so interesting is that it feels as if shes constantly trying to calibrate a model of strength that doesnt play as either re-skinned machismo or slogan-y corporate feminism.

In doing so, she has redefined what it looks like to be the veteran of the group, to have that position not hinge on grizzled physicality but on an aura of having endured unimaginable things. That Theron, a former dancer, does a lot of her own stunts is part of this. It pays off in set pieces that look more exciting and visually coherent for it, but the injuries she has accrued in doing them landing on her neck during the filming of on Flux, cracking her teeth and bruising her ribs in Atomic Blonde get held up as proof of her bona fides. While someone like Cruise, who has been similarly hurt on set, has built his current image on bouncing back and seeming bent on outrunning his own mortality, even if he has to travel to outer space to do it, a human capacity for wear and tear seems central to how Theron thinks of these roles, both in terms of the characters and her own experience of playing them. She actually considers the effects of time even when shes playing near-deities who are untouched by it, allowing these characters to develop a kind of emotional patina.

Its part of why they seem so easy in their skin their gender not downplayed in an effort to be taken more seriously but their sexuality not angled as though it exists solely for the sake of outside consumption, either. When Lorraine Broughton, Therons icy-cold character in Atomic Blonde, falls into bed with a French agent played by Sofia Boutella, its a spectacle, sure, but its not offered up as any more of one than the staircase fight sequence that follows, brutal and unforgiving and shot to look like a single long take. Theres something in the greedy decadence of the sex that definitely recalls Bond, the character who defined the spy genre, though Boutellas character is allowed more dimensionality than the standard Bond girl; shes a participant in mutually desired tryst, not a notch on Lorraines bedpost, and when she meets an ugly end later, we feel it. We feel it when Lorraine takes a blow to the face or gets thrown against the wall, too, which is something Theron insisted on when her character takes a beating, it shows on her bruised face and the blood-rimmed pupil of her eye. It makes sense that evidence of the combat, with its terrible solidity and wont-cut-away immediacy, would show on Lorraines body and that those signs of vulnerability make it seem even more impressive.

Whether its a by-product of the timing of this turn in her filmography or an element of it, the fact that Theron became an action star mid-career is key to why shes so resonant in these roles. She turned 40 three months after Mad Max: Fury Road premiered at Cannes in 2015, and while she looks largely the same now as she did when she got her start back in 2 Days in the Valley, she could bring a world-weariness to the part of Furiosa that felt extremely grown-up. With her haunted eyes and missing limb, Furiosa carries a whole history of loss and pain that doesnt need to be explained to be felt onscreen. (Though it will, if Miller gets to make the prequel hes planning one in which hell cast a younger actress, though he considered having Theron de-aged, la The Irishman.) Mad Max: Fury Road is another grittily physical movie, made primarily with practical effects and shot in grueling conditions, and Theron matched that sensibility by imbuing her character with a desperate determination. Furiosa is as much the hero as Tom Hardys Max Rockatansky, and one of the understated pleasures of the otherwise maximalist affair comes from both characters quick and unspoken recognition of the others formidability.

Theron as Andy in The Old Guard. Photo: Courtesy of Netflix

That sense of having lived through some shit is, if The Old Guard is any indication, now Therons signature. As Andy, ne Andromache of Scythia, the longest-running member of the films collective of nearly unkillable soldiers, she wears the years in counterintuitive and considered ways. She does her best to bring an outrageous characterization down to the ground with Andy, playing her not as jaded but as someone to whom longevity has given an aura of intense surety. She moves with a muscular self-assurance in the role, whether in a fight or in a conversation had while prowling along a narrow street. When Andy yanks a dagger out of her chest, its with the tamped-down exasperation that someone might display when theyve just been put back on hold while on the phone with their bank. When she comes back to gasping life after being shot repeatedly, its with the resigned readiness of someone who has done so countless times before. And when Andy and Nile (KiKi Layne) brawl in the tight quarters of a cargo plane in flight, what dawns on Therons face as she shows off the martial-arts training she has been accruing is an unexpected look of delight. Its a sign that her character can still take pleasure in a fight and that, after so many millennia, the world still holds some surprises for her.

Theron herself has already lived multiple lives in the industry. She started off playing the sex kitten in films like That Thing You Do! and Reindeer Games, then painstakingly navigated her way into the kind of chameleonic, deglamorized parts so often regarded as markers of artistic gravity, like her roles in Monster and North Country. She hasnt left that behind just last year, she put on prosthetics and lowered her voice to appear as Megyn Kelly in Bombshell but as she has gained more sway over the projects she opts to appear in, she has gravitated toward a particular kind of action the most. Its one that feels related in battered spirit to the spate of movies over the past decade-plus starring Liam Neeson, Keanu Reeves, and Denzel Washington as seasoned characters dragged back into the game. But in other ways, it doesnt not just because Theron is younger, but her characters arent getting pulled out of retirement. They never left, and theyre still in their prime. To play the character at the center of the story, to be active instead of watching in the wings thats power. But more powerful still is to be the character who has been at the center for a while, and who brings the weight of that past with her going forward.

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The Brutal Pleasure of Watching Charlize Theron Turn to Action - Vulture

In Remission for 10 Years: Long-term Data on CAR-T Therapy – Medscape

When a patient with cancer hears there isn't much left that doctors can do, it always stays fresh in the mind.

Doug Olson was first diagnosed with chronic lymphocytic leukemia (CLL) over 20 years ago, in 1996. For several years, his doctors used the watch-and-wait approach. But then his cancer progressed and needed treatment. By 2010, it had mutated so much that it no longer responded to standard therapy.

He was rapidly running out of options. Back then, the only treatment left was a bone marrow transplant. Without one, his doctors said, he would have 1 or 2 years left to live.

"I was really trying to avoid a bone marrow transplant. You're playing your last card if that doesn't work. It's a pretty rough procedure," Olson told Medscape Medical News.

Looking back, Olson counts himself as lucky for being in the right place, at the right time, with the right doctor. His oncologist was David Porter, MD, the principal investigator on a trial at the University of Pennsylvania that was investigating a brand new approach to treating cancer: chimeric antigen receptor (CAR) T-cell therapy.

CAR T-cell therapy uses a patient's own T cells engineered to express a receptor that targets proteins on cancer cells. CAR T cells are considered "living drugs" because they expand inside the body and stick around for years maybe for a lifetime to fight the cancer if it tries to come back.

"I was certainly intrigued by the approach. It had worked in mice, and it was the sort of thing that looked like it would work," Olson recalled.

Science is not a foreign language to Olson. He holds a PhD in medicinal chemistry, spent most of his career in the in vitro diagnostics industry, and currently acts as chief executive officer of Buhlmann Diagnostics Corp.

So he read the clinical protocol for the first in-human trial of CAR T cells and agreed to become patient number two.

Olson's T cells were harvested, engineered to attack the CD19 antigen found on malignant and normal B lymphocytes, and then were expanded into millions in the lab. After undergoing preconditioning with chemotherapy to minimize rejection and boost the CAR T cells' expansion inside the body, he received several infusions of the new therapy over the course of 3 days.

Nothing really happened for 2 weeks. Then he developed severe flu-like symptoms so bad that he was hospitalized.

Ironically, getting sick was a sign that the CAR T cells were working. Olson was experiencing one of the main short-term effects of CAR T-cell therapy: cytokine release syndrome. Symptoms include extremely high fevers and dangerous drops in blood pressure that can potentially cause end-organ damage.

In the early trials of these products, some patients experienced such a severe reaction that they needed intensive care, and some died. With increasing clinical experience, doctors have learned to control the reaction with the use of steroids and interleukein-6 inhibitors such as tocilizumab (Actemra).

Fortunately for Olson, the reaction passed, and he was eventually discharged.

Then the "aha moment" happened. Four weeks after receiving the CAR T cells, Olson found out that he was cancer free.

"It still gives me shivers," he said. "Dr Porter said, 'Your bone marrow's completely free. We just can't find a cancer cell anywhere.' "

The remission has lasted, and it is now 10 years later.

Long-term data have been accumulating for these novel therapies since Olson's treatment in 2010. This is particularly important for CAR T-cell therapy, because of its longevity. Because these are living cells and are expected to persist in the body for years, there is great interest in longer-term data, especially the risks for toxicity.

The FDA requires clinical follow-up for at least 15 years for patients treated with CAR T-cell therapy or any other genetically modified cells.

So far, most of the experience with CAR T cells comes from anti-CD19-directed therapy, which has shown "remarkable" remission rates in the 50% to 85% range, said Nirali Shah, MD, head of the hematologic malignancies section of the Pediatric Oncology Branch at the National Cancer Institute (NCI).

The most recent results presented at this year's annual meeting of the American Society of Clinical Oncology support earlier efficacy data, she noted. In the longest follow-up to date, researchers reported remissions lasting over 9 years in patients with relapsed/refractory B-cell lymphoma or CLL treated with Kite's axicaptagene cilleucel (Yescarta), one of two anti-CD19-directed CAR T-cell therapies approved by the FDA in 2017 (the other is Novartis' tisagenlecleucel [Kymriah]).

This study included 43 patients and showed an overall remission rate of 76%. Complete remission was achieved in 54% of patients, and 22% had partial remission.

The other focus is long-term safety. Although some of the long-term adverse effects are known and are manageable, others fall into the theoretical realm. In early May 2020, the NCI held a multidisciplinary virtual conference on CAR T-cell therapy "to encourage collaborative research about the subacute and potentially long-term toxicity profile of these treatments."

"We know just a little at this point about late- and long-term effects of CAR-T therapy, because we are relatively early in the era of CAR T cells," said Merav Bar, MD, from the Fred Hutchinson Cancer Research Center in Seattle, Washington.

What is known is that B-cell aplasia represents the most common long-term adverse effect of CAR T-cell therapy. B-cell aplasia results when anti-CD19 CAR-T therapy wipes out healthy B cells as well as the malignant ones responsible for leukemia/lymphoma.

As major players in the immune system, B cells are a key defense against viruses. So B-cell aplasia represents a very specific type of immunosuppression. It is generally less severe than immunosuppression that occurs after organ transplant, which hits the immune system pretty much across the board and carries a much higher risk for infection.

The main concern is what happens when someone with B-cell aplasia encounters a new pathogen, such as SARS-CoV-2.

After infection, B cells generate memory cells, which are not killed off by anti-CD19 therapy and that stick around for life. So a patient such as Olson would still make antibodies that fight infections they experienced before receiving CAR-T therapy, such as childhood chickenpox. But now they are unable to make new memory cells, so these patients receive monthly immunoglobulin infusions to protect against pathogens they have not previously encountered.

Olson takes this in stride and says he isn't overly worried about COVID-19. He follows the recommended precautions for a man his age. He wears a mask, washes his hands frequently, and tries to maintain social distancing. But he doesn't stay locked up in his New Hampshire home.

"I took the attitude when I was diagnosed with cancer that I'm going to live my life," he said. "Quality of life to me is more important than quantity."

Another problem is the possibility of neuropsychiatric toxicity. Past studies have reported a wide range of such toxicities associated with CAR T-cell therapy, including seizures and hallucinations. Most have occurred early in the course of treatment and appear to be short-lived and reversible. However, there remain questions about long-term neuropsychiatric problems.

In a long-term study of 40 patients with relapsed/refractory CLL, non-Hodgkin lymphoma, and ALL, nearly half of patients (47.5%, 19/40) self-reported at least one clinically meaningful negative neuropsychiatric outcome (anxiety, depression, or cognitive difficulty) 1 to 5 years after anti-CD19 CAR T-cell therapy. In addition, 37.5% (15/40) self-reported cognitive difficulties.

"Patients with more severe neurotoxicity showed a trend for more cognitive difficulties afterwards," said Bar, senior author of the study.

However, teasing out the role that CAR T-cell therapy plays in these problems poses a challenge. All of these patients had been heavily pretreated with previous cancer therapy, which has also been associated with neuropsychiatric problems.

"So far, we don't know what caused it," Bar said. "Nevertheless, people need to pay attention to neuropsychiatric symptoms in CAR T-cell therapy. It is important to continue to monitor these patients for these issues."

Another potential problem is graft-vs-host disease (GVHD). This is not uncommon after hematopoietic stem cell transplants. It develops when the donor T cells view antigens on healthy recipient cells as foreign and attack them.

For patients who are treated with CAR T cells, GVHD is mostly a concern among individuals who have previously had a transplant and who are already at increased risk for it.

In a study of late effects among 86 adults treated with anti-CD19 CAR T cells for relapsed/refractory non-Hodgkin lymphoma, Bar and colleagues found that GVHD occurred only among patients who had received a previous donor stem cell transplant. Of these, 20% (3/15) developed GVHD about 28 months after CAR-T therapy.

"The data for CAR T cells causing GVHD really hasn't shown that it's a huge problem, although we have seen it and are continuing to monitor for it," the NCI's Shah commented to Medscape Medical News.

A range of other long-term adverse effects have been reported with CAR-T therapy, including prolonged cytopenias (reduced mature blood cells), myelodysplasia (bone marrow failure), and second malignancies.

In the study with the longest follow-up to date, 16% (7/43) of patients developed second malignancies, which is comparable to data from Bar's study in Seattle (15%, 13/86). The researchers in this study consider this rate to be no higher than expected: these patients had already received extensive chemotherapy, which increases the risk for other cancers, they point out.

However, this brings up theoretical concerns about the long-term effects of gene modification. CAR T cells are engineered using retroviruses (mainly lentiviruses), which randomly insert the CAR genes into the host genome. Doing so may cause mutations that could promote cancer. These lentiviruses also carry the theoretical risk of becoming capable of viral replication once inside the body.

To address these concerns, viruses used to engineer CAR T cells go through comprehensive safety testing. After therapy, patients are checked every few months during the first year and annually after that.

So far, there have been no reports of cancers associated with CAR T-cell therapy.

"Any type of cancer is a very theoretical risk," Bar told Medscape Medical News. "Most likely the malignancies in our study were related to prior treatment that the patients received. None of them had any evidence of replication-competent lentivirus, or any other evidence that the malignancies were related to the CAR T cells."

Another theoretical concern is the possibility of new-onset autoimmune disease, although, once again, no cases have been reported so far.

"We think of it as a theoretic possibility. Whenever you jack up the immune system, autoimmune disease is a potential risk," said Carl June, MD, director of the Center for Cellular Immunotherapies at the University of Pennsylvania.

June was the coprincipal investigator of the trial in which Olson participated. He is also the inventor on patents for CAR T cells licensed by the University of Pennsylvania to Novartis and Tmunity and is a scientific founder with equity in Tmunity.

Still, autoimmunity could occur, and scientists are looking out for it.

"We are continuing to be vigilant in our monitoring for autoimmune disease," Shah added. "We've been doing CAR T-cell therapy since 2012, and I think we have yet to see true autoimmunity beyond GVHD."

In the 10 years since Olson received CAR T-cell therapy, an entire industry has sprung up. Over 100 companies worldwide are now developing CAR T-cell therapies targeting various antigens. These therapies are directed at about 60 different tumor types, including solid tumors. Nearly 200 clinical trials are underway, though most are still in early stages: as of September 2019, only 5% had reached phase 3.

Clinical data show promising results for CAR T-cell therapy directed against CD22 (overexpressed on ALL cells), and BCMA (found on almost all multiple myeloma cells). Yet questions remain as to whether CAR T cells will be as effective if they target antigens other than CD19 or cells other than B lymphocytes. One of the biggest research questions is whether they will be effective against solid tumors.

One research avenue being watched with great interest is the development of universal CAR T cells. So far, such products are at very early stages of development (phase 1 trials), but they are attractive because of the potential advantages they offer over bespoke CAR T cells. Automating the process holds the promise of immediate availability, standardizing production, expanding access, and lowering costs. And because the T cells for this universal product come from healthy donors, they may function better than T cells that have been battered and bruised by past cancer treatments, or even the cancer itself.

However, precisely because they are developed from healthy donor T cells, universal CAR T cells may pose increased risk for GVHD. Scientists are trying to get around this problem by engineering universal CAR T cells that lack the T-cell receptor involved in GVHD.

There are also other concerns. Nature has a penchant for mutation. Engineering CAR T cells without T-cell receptors means the body may no longer detect or reject a universal CAR T cell if it goes rogue. Also, gene insertion in universal CAR-T therapy is targeted rather than random (as in bespoke CAR T cells), which could create off-target effects. Both issues create a theoretical risk of such products inducing an untreatable CAR T-cell therapyassociated cancer.

"The theoretic risk with universal cells is that their safety profile may not be as good for long term," June commented.

From that first trial in which June and Porter used CAR T cells, two of three patients they treated are still alive 10 years later.

Olson is one of these two, and he still undergoes monitoring every 3 months to check for relapse. So far, none of his tests have shown signs of his cancer returning.

After going into remission, Doug spent the next 6 to 9 months regaining his health and strength.

"I figured if I had this amazing treatment that saved my life, I had an obligation to stay alive," he said. "I'd better not die of something like a heart attack!"

He took up long distance running and has completed six half marathons. He became involved in the Leukemia and Lymphoma Society, participating in fund-raising and helping newly diagnosed patients. Over the years, he has also given talks for researchers, people with cancer, and healthcare providers.

Doug is now 73. Today, he marvels at how rapidly the CAR-T field has progressed.

"Twenty years ago, if you had cancer, your prospects weren't nearly as good as these days. In 2010, people still didn't believe in CAR T-cell therapy," he said. "My goal always in telling my story is a message of hope."

For more from Medscape Oncology, join us on Twitter and Facebook.

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In Remission for 10 Years: Long-term Data on CAR-T Therapy - Medscape

G20 countries in Asia Pacific are not prepared for the needs of ageing populations, according to new research from the Economist Intelligence Unit -…

HONG KONG, CHINA - Media OutReach - 22 July 2020 - Morepeople are living into old age than ever before. In 2018 The World HealthOrganization predicted that by 2020 there would be more people aged over 60years than there are children under 5 years. This prediction is on track to becorrect,and numbers in the older cohort continue to rise. This hascreated challenges in providing health and social services for burgeoning olderpopulations and governments across the globe have been slow to react.Priorities are now shifting from solely addressing the health of older people,to how societies can maximise this opportunity and provide effective, inclusiveenvironments in which to age.

This report from The Economist Intelligence Unit describesfindings from the "Scaling Healthy ageing, Inclusiveenvironments and Financial security Today" (SHIFT) Index", a benchmarking analysis around ageingsocieties. The SHIFT Index benchmarksagainst a set of national-level leading practices in creating an enablingenvironment supportive of longevity and healthy ageing for societies in the 19countries comprising the Group of Twenty (G20). The SHIFT Index captures the multifactorial variables that impactageing across three domains: adaptive health and social care systems;accessible economic opportunity; and inclusive social structures andinstitutions.

The research found that no G20 country isfully prepared to support healthy, financially secure, socially-connected olderpeople. The US, Australia, Canada and South Korea ranked highest in our indexwith scores in the 70s out of 100 (see table below). Broadly, those countrieswith a higher proportion of people aged over 50 -- including the three highest ranking countries plus South Korea,Germany, France and Japan -- are implementing moreleading practices to enable inclusive environments. Wealthy countries may findit easier to respond, but wealth is not a prerequisite for providing supportiveenvironments. The best scoring health systems tend to be high-income countries,but upper-middle income Brazil, and lower-middle income Indonesia are alsomaking strides to improve health systems.

As a whole, the G20 countries perform bestin providing adaptive healthcare systems and worst in providing inclusivesocial structures and institutions, indicating that countries still have workto do to shift the focus towards building more welcoming societies for olderadults as they age. Countries also have room to improve in providing moreaccessible economic opportunities to older workers.

Despite clear progress made, governmentshave more work to do to make sure their health systems are adaptive to theneeds of older adults as they age, while also fostering inclusion and ensuringindividual economic security. A keybarrier to addressing this is lack of robust age-disaggregated data collectionby governments in areas such as dedicated health professionals, the extent ofisolation and loneliness as well as mental health.

The SHIFTIndex reveals several priority areas that may form the basis of policyresponses to develop more accessible and inclusive societies for older people:

Jesse Quigley Jones, managing editor at TheEconomist Intelligence Unit and editor of the report, said, "The challengesthat ageing populations present for economies and health systems have long-beenunderstood, yet provision of inclusive, supportive environments for olderpeople has not been a high-profile policy priority. Although wealth has emergedas a theme in the Index as a contributing factor towards healthy ageingindicators, it is not necessarily a prerequisite for providing supportiveenvironments. Lower-income nations can take low-cost measures that improveageing societies, such as enacting inclusive work environment policies andfostering inclusive and enabling social environments.

With older people particularly vulnerableto the health and societal impact of the covid-19 pandemic, it is moreimportant than ever for older people to lead healthy, independent lives for aslong as possible and avoid the need for institutional care. While our data werecollected pre-pandemic, the priorities identified in the report are now throwninto sharper light and may serve as a wakeup call for governments across theglobe for providing adaptable, accessible and inclusive environments in whichpopulations can age."

Forthe whitepaper, infographic and index workbook, please visitageingshift.economist.com

Shifting demographics: a global study oninclusive ageing is a report by The EconomistIntelligence Unit, supported by Amgen. It considers policy efforts to addressactive and inclusive ageing in 19 countries based on a first-of-its-kind indexthat benchmarks each country's performance across accessible and affordablehealthcare, social connectivity among older adults, and finance securitypractices and policies.

The "Scaling Healthy ageing, Inclusiveenvironments and Financial security Today" (SHIFT) Index and the relatedresearch programme whose findings form the basis for this report were informedby extensive research and guided by an international panel of experts fromacross academia, government, non-governmental organizations (NGOs) andinternational financial institutions.

The following 19 countries (comprisingthe G20 and excluding the EU) are included in this analysis: Argentina,Australia, Brazil, Canada, China, France, Germany, India, Indonesia, Italy,Japan, Mexico, Russia, Saudi Arabia, South Africa, South Korea, Turkey, the UKand the US. These were selected to broadly represent the world: coveringroughly 65% of the population and 75% of global GDP.

The EconomistIntelligence Unit is the world leader in global business intelligence. It isthe business-to-business arm of The Economist Group, which publishes TheEconomist newspaper. The Economist Intelligence Unit helps executives makebetter decisions by providing timely, reliable and impartial analysis onworldwide market trends and business strategies.

More informationcan be found at http://www.eiu.com or http://www.twitter.com/theeiu

Amgen is committedto unlocking the potential of biology for patients suffering from serious illnesses,by discovering, developing, manufacturing and delivering innovative humantherapeutics. This approach begins by using tools like advanced human geneticsto unravel the complexities of disease and understand the fundamentals of humanbiology.

Amgen focuses onareas of high unmet medical need, and leverages its expertise to strive forsolutions that improve health outcomes and dramatically improve people's lives.A biotechnology pioneer since 1980, Amgen has grown to be one of the world'sleading independent biotechnology companies, has reached millions of patientsaround the world, and is developing a pipeline of medicines with breakawaypotential.

For moreinformation, visit http://www.amgen.com or http://www.twitter.com/amgen.

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G20 countries in Asia Pacific are not prepared for the needs of ageing populations, according to new research from the Economist Intelligence Unit -...

Cellular Reprogramming Tools Market Is Forecasted To Register A CAGR Growth Of XX% Between And 2020-2030 Bulletin Line – Bulletin Line

Global Cellular Reprogramming Tools market size will reach xx million US$ by 2025, from xx million US$ in 2018, at a CAGR of xx% during the forecast period. In this study, 2018 has been considered as the base year and 2019-2025 as the forecast period to estimate the market size for Cellular Reprogramming Tools .

This industry study presents the global Cellular Reprogramming Tools market size, historical breakdown data (2014-2019) and forecast (2019-2025). The Private Plane production, revenue and market share by manufacturers, key regions and type; The consumption of Cellular Reprogramming Tools market in volume terms are also provided for major countries (or regions), and for each application and product at the global level.

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The following manufacturers are covered in this Cellular Reprogramming Tools market report:

Key Players

Some examples of key participants operating at the global level include Celgene Corporation, BIOTIME, INC., Human Longevity Inc., Advanced Cell Technology Inc, Mesoblast, STEMCELL Technologies Inc., Osiris Therapeutics Inc., Cynata, Astellas Pharma Inc., FUJIFILM Holdings Corporation, EVOTEC, Japan Tissue Engineering Co., Ltd and some others.

The research report on cellular reprogramming tools market presents a comprehensive assessment of the market and contains thoughtful insights, facts, historical data, and statistically supported and industry-validated market data. It also contains projections using a suitable set of assumptions and methodologies. The research report on cellular reprogramming tools market provides analysis and information according to market segments such as geographies, application, and industry.

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The report on cellular reprogramming tools market is a compilation of first-hand information, qualitative and quantitative assessment by industry analysts, inputs from industry experts and industry participants across the value chain. The report provides in-depth analysis of parent market trends, macro-economic indicators and governing factors along with market attractiveness as per segments. The report also maps the qualitative impact of various market factors on market segments and geographies.

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This report includes the estimation of market size for value (million USD) and volume (K Units). Both top-down and bottom-up approaches have been used to estimate and validate the market size of Cellular Reprogramming Tools market, to estimate the size of various other dependent submarkets in the overall market. Key players in the market have been identified through secondary research, and their market shares have been determined through primary and secondary research. All percentage shares, splits, and breakdowns have been determined using secondary sources and verified primary sources.

For the data information by region, company, type and application, 2018 is considered as the base year. Whenever data information was unavailable for the base year, the prior year has been considered.

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Cellular Reprogramming Tools Market Is Forecasted To Register A CAGR Growth Of XX% Between And 2020-2030 Bulletin Line - Bulletin Line

When it comes to longevity, here’s why any exercise is good exercise – AZ Big Media

We all know that exercise benefits us physically, but ripped abs and a healthy heart arent the only advantages to hitting the gym. The sense of camaraderie, structure and accomplishment we get from physical activity all speak to its myriad social benefits.

But with everyone at more than arms-length these days, the social aspect of exercise is what many of us have been missing most its also whatConnor Sheehanis most interested in.

An assistant professor at ASUsT. Denny Sanford School of Social and Family Dynamics, Sheehan was curious to know which, if any, of the more socially oriented exercises, such as team sports, contribute to longevity.

In a paper co-authored with family and human development graduate student Longfeng Li and recently published in the journal Medicine and Science in Sports and Exercise, the researchers found that any exercise is beneficial, but stretching, volleyball and fitness exercises (i.e., walking, aerobics, cycling, etc.) in particular were associated with lower rates of mortality.

Its one of the most replicated scientific facts that exercise is good for humans and helps us live longer, Sheehan said. And a lot of research has been focused on the physiological benefits. But Im a sociologist, so I think that exercise also benefits us sociologically by giving us other things that humans need, like social contact. And of course, America is a really diverse society where people do a bunch of different exercises. So we wanted to see how those exercises stacked up against each other and which exercises led to longer life spans.

In their study, which was funded by a grant from ASUsGlobal Sport Institute, Sheehan and Li used data collected by the National Health Interview Survey of 26,727 American adults ages 18 to 84 to examine the effect of 15 different exercises on mortality rates. The survey participants were asked once in 1998 what type of exercise they engaged in, then followed for all-cause mortality through the end of 2015.

During 17 years of follow-up, 4,955 deaths occurred. After adjusting for such factors as demographics, socioeconomic status and health behaviors, researchers found that walking, aerobics, stretching, weight lifting and stair climbing were related to lower risks of mortality. When adjusting for engagement in all exercise types, stretching and volleyball were found to be uniquely associated with lower risks of mortality.

Their findings suggest that some types of exercise have unique benefits for longevity, but most are indistinguishable in relation to longevity.

What that means, Sheehan said, is that if youre doing any exercise, thats better than if youre doing nothing. So I think whats best is to just keep doing what you can consistently do, what you consistently enjoy doing. I wouldnt go out of your way to adjust your lifestyle to the results of this study, because it might be harder for you to stretch than to play volleyball, for instance.

One exercise they found to have a negative effect on longevity was baseball, which they presume is due to the culture of chewing tobacco associated with the sport. And surprisingly, in spite of its association with the neurodegenerative disease chronic traumatic encephalopathy (CTE), they did not find that football was associated with increased mortality.

In addition, Sheehan and Li found that the benefits of exercise did not vary across different types of social groups, meaning any type of exercise is good for everyone.

You can promote any type of exercise and everyone gets equal benefit, Sheehan said. So exercise and engagement in sports should be foundational in promoting population health.

However, he was hesitant to state whether the studys findings support an argument for a return to in-person, community and professional sports.

You have to balance the physical risk of getting a disease that can permanently alter the health of young people with the social benefits they would be getting from team sports, he said. Its tricky.

One exercise Sheehan and Li were unable to measure that was less popular in 1998 but has quickly become a virtual favorite during quarantine is yoga.

Yoga is so good for times like these because you dont need much space, you dont need much equipment and its good for mental health, he said.

And while it might be hard to play volleyball or basketball on Zoom, Sheehan said that whatever helps you do any exercise so that youre getting physiological and social benefits is best.

If what was driving you to go to yoga was that you were doing it with your friend, and you can now do YouTube yoga over Zoom, thats going to help bring back the social benefits with the physiological benefits, he said.

Sheehan, who has conductedresearch on sleepin the past, is interested in expanding on these most recent findings to see how different types of exercise affect sleep quality.

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When it comes to longevity, here's why any exercise is good exercise - AZ Big Media

Beyond the Mask | Free – Emporia Gazette

Ill start by saying this: masks are important right now. For the immediate future we need to get people on board about taking our actions seriously in a different manner. Our way of living has changed and working with each other is for the betterment of humanity. That is to say, if we all love life then we need to work together.

Ill continue by saying this: humans were not meant to live in masks for the rest of our existence. We must live IN the world, not hide from it behind band-aids. Masks do not cure, prevent, or keep us safe from any future (or present) diseases that the world throws at us. They are a temporary measure that have fast become a sticky subject within our culture.

This is the ideal time in history to look at our personal health more thoughtfully. Americans have gorged themselves on cheap, fried, nitrate-ridden, gluttonous diets for decades now. Many of us think mowing the yard is a good days exercise or that drinking a glass of water for every soda is a healthy ratio. Our way of life, as it might be tolerable, does not allow us to thrive. It barely allows us to survive.

The environment we live in is much more toxic than it was even 50 years ago. The quality of what we ingest, be it air, food, drink, visually or even socially is degrading by the year. Our bodies are continually working harder to keep us from growing old. Diseases such as diabetes, cancer or even a heart condition may be attributed to how we live our lives.

We must continue to evolve how we exist on our planet and the thing that each of us can do going forward is to take our health into our own hands.

Things such as hormone balance, foods that boost our immunity, correct exercise for longevity, and meaningful mental health practices are all things that are much more productive in preventing sickness. In addition, they add years or even decades to the quality of life for humans. Ive studied these benefits over the past 12 years and was sold on the win-win of longevity and health when I started to see the benefits in my own life.

There is not a magic bullet, but there is a lot of pertinent information out there. With the level of unknown at this point in 2020 it is only prudent to do what we can personally to help ourselves.

Consider going to drjboss.com to start your information gathering and to begin to think differently about our current situation in 2020. There are also great places here in Emporia such as Natures Paradise Health Food Store that have great personal advice on rebooting the body towards longevity. Biohacking is the next trend and newest weapon for the human race to combat our anxieties in the world.

Fighting, ridicule and fear are not going to help us get back on track, but certainly health measures are a step in the right direction.

Wouldnt it be great to not wear masks? When coronavirus has subsided, who is to say that tequila virus wont be next? Or trench foot? The world is full of vaccines that are less than 50 percent effective. Personal health is under your control and gives you a better place in the world for a brighter life and a safer future.

To mask or not to mask? That is one of the main questions in society right now. But the answer is not in the mask; the solution is within us.

Cory Bosiljevac

Marketing Executive

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Beyond the Mask | Free - Emporia Gazette

Life, Creative & On The Edge – The Free Weekly

The coming weeks and months will be very challenging for humanity. The present, continuing and upcoming transits, phenomenal in their power, force, strength and multiplicity (with more to come), have long- range, enduring effects on humanity and all of our endeavors. This is the year of multiple retrogrades. Retrogrades turn us inward in order to assess the quality of our lives and things we need to change. During July and August, eight lights in the sky are retrograde. For now, Mercury retrograde ends Sunday(at 6 Cancer). And Mars (retrograding in September) is in Aries (fire, red, war, inflammations, reactions). Thus, we can understand the state of our world.

Mars in Aries is partially why we are seeing such out of control behaviors. Mars, on the personality-building level, is desire, action, anger, assertion, aggression and war it is how the personality stumbles towards learning Right Human Relations and peace (Libra). Mars and Aries work together. They initiate things with fiery will. Mars in Aries (spiritually) calls humanity to learn about itself, to cultivate, through observation, its true self identity.

Mars, the color red, inflames emotion and events; interactions are reactionary, intense and fiery. Its life on the edge. We experience flare ups, anger, frustration, impatience, criticism, judgments. Temperatures rise and people are in reactive and destructive states. We find many people reactive, under illusions, and unaware of consequences.

How do we neutralize these things? Each day, prepare for the unexpected. Creating the good, resisting that which is not good.Understanding the difference. Discerning the two.

When creating the Good, the unexpected appears to help us. Disciples understand these words. Creation is freedom. From Buckminster Fuller. We dont change things by fighting the existing reality. Build a new model that makes the old model obsolete.

ARIES: An unusual time begins for you with new views of yourself in relationship to others and a new way of working in the world (with others). Careful with communication, create a time for regular exercise, review supplements and vitamins. Sometimes fire signs cant maintain a regular constant regimen. However, its vital to your present future tasks, upcoming demands and essential to health and longevity.

TAURUS: In many ways youre becoming more like Pisces. This is not disheartening. Its rather special having Pisces compassionate characteristics. Yes, its difficult to perceive earth realities, difficult to walk a straight line and keep balance. Sometimes you stumble along, knowing only the present moment is real. Even with all these physical obstructions, seeing differently as you do, you still save the world. Your protector is the elephant god Ganesh. Pray to him to remove all hindrances and obstacles.

GEMINI: The message each week seems the same the community and groups you will participate in, the duality you present, the love and synthesis gifts for Gemini from Sirius. Soon you must begin to discern which groups are part of the New Group of World Servers, the people of Goodwill. It is important to discriminate between the real and the false light. What groups are you magnetized toward? What calls to you each day? What voices are you listening to?

CANCER: So many things are ending, culminating. Long held hopes and wishes are falling away. What new opportunities do you now seek? As you study new information, especially about herbs, flowers, roots, foods and gardening, you will understand more how to safeguard and sustain yourself and family. Know the devas in the gardens have a deep love for you. They offer a high vibrational yet subtle healing.

LEO: In the next year, as your horizons expand, you will enter new groups and endeavors. And find new friends that love you. You continue to wonder about lands far away. The unusual and culturally different places and people are of interest to you. Youre ready soon for a new reality. See the next year as a philosophical adventure containing new rhythms. You still have relationship wounds hidden away. Water and forgiveness help.

VIRGO: Summon and act upon values that make you feel empowered. In the next months your values may change. Be aware of this. You like to be practical and down to earth. Use your money to empower yourself and to empower and assist others. The past is over. New messages need to be sent. Be aware of impatience and impulsiveness with spending. Use resources with deep respect and with gratitude. And to serve.

LIBRA: Good yet unusual events unexpectedly occur in the next months. As realities shift and change in the world, create deeper roots where you live and with those you care for and love. Use resources wisely. Grow a vegetable garden. Get a green house. Prepare for a different future. Ask ones partner and/or friends about goals, dreams, wishes, hopes, fears. Come from the heart, always. You are fierce and independent sometimes. Slow down and rest a bit.

SCORPIO: In all things, especially food, diet, health, exercise there must be a constancy and regularity. A daily rhythm. This will be a challenge. The chaos in our world can create tension and fear, unevenness and chaos. Anything in excess over time creates a health situation. Observe your health with care. Ask if your daily work serves you. Over time, your spiritual courage will change either the work you do or your perceptions about work. When you speak (write) people listen.

SAGITTARIUS: You will have days of transformation and days of harmony, days of sadness and days of ease and beauty. This tension creates attention to creating a new life, new essential artistic things (artistic) as you express yourself differently. Each day, plan on enhancing and improving everything around you. You are the steward of your life. In between, you need a new sense of play, of fun and pleasure, and new towns and cities to explore.

CAPRICORN: At times we all want to flee our world and run away from home. Running is good (for exercise, to run a race), but always you come home again. Mars is keeping you home, close to the land and perhaps in a garden. You are remembering your early life, the events and situations and people of long ago. Youre attempting to understand the psychological structures of your upbringing. It gives you a new sense of self identity. Mother played a big part in this. Write.

AQUARIUS: Are you learning new information, in a new environment. Is it offering you a new philosophy, a new sense of understanding the world? Is your neighborhood one that inspires you, offers a greater view of life? It is good to be in contact with brothers and sisters, relatives, family. Everyones changing. You are, too. Share your life with them, ask about their lives. Careful with money and resources. Write in your journal every day about your everyday life. Youre learning life is magical.

PISCES: Youre in deep waters, on the edge of new archetypes, waiting for new realities, developing new values, learning about resources and money, Right Stewardship and Right Timing. You want to begin something. You seek a refuge and safe haven for self and other. In Permaculture, which observes living systems and how they relate, the most diversity exists at the edges. It is here that change happens naturally. Remain always at the edge. Life, creative and on the edge, happens there.

~Risa writer, teacher, counselor, mentor, astrologer, esotericist

Founder & Director

The Esoteric & Astrological Studies & Research Institute

-a contemporary Wisdom School for the Ageless Wisdom teachings.

The foundations of the Teachings are the study & application of Astrology

& the Seven Rays.

~Email: risagoodwill@gmail.com

~Web journal: http://www.nightlightnews.org/

~Facebook: Risa DAngeles & Risas Esoteric Astrology (2 FB pages)

All FB messages are posted on NLN (website) under Daily Messages

-Astrological, esoteric, day to day news art, literature, psychology, history, geography, religious, economic & cultural journalism.

Originally posted here:
Life, Creative & On The Edge - The Free Weekly

Northampton approves new budget – The Roanoke-Chowan News-Herald – Roanoke Chowan News Herald

JACKSON We just want to do all we can for the citizens in our county.

Thats one of the things Northampton Board of Commissioners Chair Charles Tyner said at their special meeting here June 29 after the Board unanimously adopted the budget for the new fiscal year.

Thanking both the Finance Department and County Manager Charles Jackson for their hard work on developing the FY21 budget, Tyner said he was glad to see several different things included such as funds for nonprofit support and economic development.

This budget will decrease our tax by half a cent. Some of you say its not much, but its more than it was in the past, he also noted.

As presented by Jackson in his budget proposal earlier in June, the FY21 budget includes a half cent reduction in ad valorem taxes, bringing the tax rate to $0.91 per $100 of property value. This follows a half cent reduction from the previous year as well.

The county will operate on a total budget of $34,138,435 which is an increase of over $1.4 million from FY20. A total of $27.9 million of that money will be in the General Fund budget.

As in previous years, the majority of the countys revenue is expected to come from ad valorem taxes, totaling $17,804,408. Thats down $1.07 million from the previous year. Other major sources of revenue include Sales Tax ($3.2 million), Sales & Services ($2.1 million), and Health Revenue ($940,505). Compared to FY20, both Sales Tax and Sales & Services are both expected to bring in more money than before, while Health Revenues are expected to drop.

For expenditures, the departments receiving the largest allocations include Public Safety, General Government, Education, Human Services (Health), Human Services (Other), and Economic/Physical Development.

With an increase of $510,000 from the previous year, Public Safety will receive the most funding at $10,927,455. The largest portions of these funds will go towards ambulance service ($3.9 million), sheriff ($3.2 million), jail ($1.8 million), and emergency communications ($1.8 million).

Public Safety allocations also include items such as contributions to local rescue squads and funding for the regional airports and CPTA. Jackson reported in his budget proposal presentation in early June that these things fall under the category of citizen quality of life which is one of four key funding priorities for this fiscal year.

General Government received a slight increase in funding this year, bring their total allocation to $4,555,883. The areas which will gain the biggest portion of these funds include buildings and grounds ($1.04 million), finance ($673,449), and tax ($568,015). Each of these allocations are slightly lower than they received in FY20.

Funding for Education was almost exactly the same amount as the previous year, totaling $4,037,000. The bulk of that allocation ($3.5 million) will go to Current Expense for Northampton County Schools, the same amount as FY20 despite the districts request of $4 million for current expense. The school district will also receive $350,000 for Capital Outlay.

Halifax Community College and Roanoke-Chowan Community College, which both serve students in Northampton County, had no change in funding amounts from the previous year. HCC was allocated $97,000 and RCCC received $30,000.

Approximately $492,000 was cut from the Human Services (Health) funding for FY21, bringing the total allocation to $3,422,178. Home health ($1 million), health ($943,308), environmental health ($247,707), family planning ($219,590), and school nursing funding ($150,000) are the areas which will receive the most funding.

Human Services (Other) was allocated $1,681,756 for this fiscal year, a drop from the $2.2 million in FY20. The bulk of that allocation went to the countys Department of Social Services (DSS).

One major change in the Human Services (Other) category from the previous year is the absence of funding for the Office of Aging. According to Jacksons proposal, the county is planning to restructure the Office on Aging, and all of its services were transferred to DSS for FY21. It also noted that the county will receive $305,000 in Home and Community Care Block Grant funds to provide services such as nutrition, transportation, adult day care, and more.

Economic/Physical Development received an increase in funding this fiscal year, bringing its total to $1,053,392.

One new thing included in the budget this year is money allocated for main street improvements in each of the countys municipalities. Theyll receive $1,000 each to invest in ways to fix up what is often the busiest part of their towns.

A difference in the budget from the previous year, however, is that theres no cost of living raise for county employees due to budget constraints stemming from the COVID crisis. Merit and longevity pay will still be funded, and Jackson did recommend funding for a compensation studythe first in almost 20 yearsto determine competitive pay policies for employees going forward.

No citizens chose to submit comments on the budget at the public hearing which was held on June 15.

At the June 29 meeting, there was no discussion on the budget amongst the Board after Tyners praise for the hard work which went into getting everything together. Commissioner Joyce Buffaloe provided the motion to approve, Commissioner Kelvin Edwards seconded, and the vote passed unanimously.

The new budget went into effect on July 1.

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Northampton approves new budget - The Roanoke-Chowan News-Herald - Roanoke Chowan News Herald

Every Dog Year Isnt Equal To 7 Human Years, Researchers Now Say – CBS Baltimore

(CNN) How do you compare a dogs age to that of a person? A popular method says you should multiply the dogs age by 7 to compute how old Fido is in human years.

But new research published Thursday in the Cell Systems journal debunks that method. And thats because the scientists behind a new study say dogs and humans dont age at the same rate.

Researchers at the University of California San Diego School of Medicine have developed a new formula that takes into account that variance.

Tracking molecular changes in the DNA of Labrador retrievers, and in particular the changing patterns of methyl groups in their genome, according to a release, the study shows how dogs age at a much faster rate than humans early in their lives, then slow down after reaching maturity.

This makes sense when you think about it after all, a nine-month-old dog can have puppies, so we already knew that the 1:7 ratio wasnt an accurate measure of age, lead author Trey Ideker is quoted as saying.

Based on the study, a one-year-old dog compares to a 30-year-old human, a four-year-old dog to a 52-year-old human. The rate of aging decreases after dogs turn 7.

The new formula is the first that is transferable across species, and scientists plan to test their findings on other dog breeds to study the impact of longevity on their findings, according to a release.

Researchers also believe that observing changes in the methylation patterns before and after the use of anti-aging products could help veterinarians make more informed decisions in terms of diagnostics and treatment.

A graphic in the study makes the age comparisons intuitive and provides some helpful context for dog owners, including the scientists themselves.

I have a six-year-old dog she still runs with me, but Im now realizing that shes not as young as I thought she was, Ideker is quoted as saying.

The-CNN-Wire & 2020 Cable News Network, Inc., a WarnerMedia Company. All rights reserved.

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How the dimensions of human inequality affect who and what we are – The Conversation CA

What does it mean to be human today? It is an excellent starting point for thinking about human inequality.

To be human, in an elementary sense, means three things.

First, you are a sexed living organism, capable of feeling pain and pleasure and of reproduction, with a delimited lifespan of development and decay, subject to vicissitudes of health and illness.

Secondly, you are a person, with a self and a reflexive capacity, flourishing or suffering in social environments.

Thirdly, you are a creative, goal-oriented actor, collective as well as individual, endowed with resources of varying size and kind.

The possibilities of flourishing as a human are shaped by processes of (in)equality. Differences are either given by God or by Nature or chosen as lifestyles.

Unlike difference, inequality is a historical social construction.

The three-dimensionality of humanity gives us three kinds of human inequality. These are vital, existential and resource.

Vital inequality refers to socially determined distributions of health and ill health and of your lifespan. It can be measured in life expectancy and in health expectancy or your years without serious illness. Where demographic life tables are missing, infant and child mortality are more accessible indicators.

Existential inequality sums up the unequal social treatment of persons. On one end of the spectrum resides denial of recognition, autonomy, existential security, dignity and respect. These can be achieved through acts of neglect, bullying, degradation and humiliation. The ultimate result is a denial of their humanness. At the opposite end are selective attention, freedom, emotional security, encouragement, respect and admiration.

Existential inequality is structured and processed by categories and lenses of othering such as sex, race, ethnicity, caste or religion. It is arguably the most hurtful and wounding of inequalities. It has given rise to a range of egalitarian movements feminist, anti-racist, nationalist, anti-caste, anti-bigotry. It has been an important driver of workers movements, in which the demand for recognition of workers human dignity has been central.

So far, however, existential inequality has received little systematic analysis and study.

It is hardly quantifiable and is difficult to compare. Legal practices and public norms, recurrent demographic and health surveys, opinion surveys, anthropological studies, autobiographies and media reporting provide qualitative evidence.

Resource inequality expresses the unequal allocation of resources to act among human actors. It is most frequently gauged through distributions of income and wealth and of so-called human capital. Less studied in this context, although highly relevant, are distributions of power and rights.

The three dimensions of inequality are interconnected and interact or intersect, but each has its own dynamic and trajectory, globally and nationally.

Othering means seeing and treating a set of people as being of a different kind than you and your type of people, as strange, peculiar and (usually) inferior.Viewing race as a category of existential othering means highlighting its character as a socio-cultural construction that is subject to change. This occurs alongside many other constructs such as gender, ethnicity, caste and religion.

In early 20th century Europe, race was often synonymous with ethnicity. For example, the British race or references to geo-ethnic groups, such as the Alpine or Mediterranean race. In continental Europe today, race is hardly used at all.

This does not mean that discriminatory and hateful othering has disappeared. It means it is now operating with other labels like Arabs, Muslims, immigrants, Africans

The existential perspective leads us to human self-formation and its connection with capability formation. The very meaning of racism and of patriarchy is to deny self-esteem and self-confidence indeed any self at all especially to black (or any other racial target) and girl children. It installs shame, self-contempt and fear instead.

Read more: Why does racism prevail? Leading scholars apply their minds

Such punitive processes are, of course, not always successful. But they often inflict lasting wounds. Prejudice and stigma act as stressors on the victims and have both somatic (bodily) and psychological effects. They also, by themselves, cause under-performance by the targets. Psychology experiments have shown that when marginalised groups are told they are inferior, they perform badly on given tasks. Conversely, when told they are expected to be superior, their performance improves.

Children of poor, oppressed and/or discriminated populations are loaded with two sets of heavy burdens. These cause many or most of them to under perform. One is the burden of social determinants, of ill-health and stunted development, which goes along with not enough emotional security and positive social stimulation. In other words, vital inequality, which bears upon capability formation. The other operates through the negative impacts on self-development of esteem, confidence and ambition by existential processes of stigmatisation, humiliation and fear.

Both these childhood experiences tend to have lifelong effects, beginning life-curves of cumulated disadvantages. Furthermore, they provide reinforcing and reproducing confirmatory evidence of inferiority of the race, gender or caste.

And when some individuals of the put-down race, gender or caste manage to break through their discrimination and oppression, this is often used as further evidence of the inferiority of the category in question. The losers are regarded as deficient persons, of low-life existence. To hardcore racists, this is inherent and inherited. But after the liberation of Auschwitz, existential inequality is more effective when leaving its genetic background unnamed.

Unequal personal selves are produced by existential inequality. And they are fortified by early cognitive and social capability formation. This can explain much of the enduring longevity of racism, patriarchy, caste and religious disadvantage, even after their formative institutions are abolished.

Such institutions of inferiority-cum-superiority have no internal dialectic of change. Change comes exogenously, from the outside, from contingent cracks of the pillars sustaining the institutions.

Sub-institutional change, of everyday existential inequality, will require broader social and cultural transformations. It will require equalising processes of self and capability formation. The current hardening of nationalism in power the existing nation-states nationalism and fundamentalist religious revival tend rather in the opposite direction.

This article is part of a series of six. Other authors include Nina Jablonski, Barney Pityana, George Chaplin, Kira Erwin, Kathryn Pillay and Njabulo Ndebele.

The three edited volumes of essays published by African Sun Media in 2018 (The Effects of Race, edited by Nina G. Jablonski and Gerhard Mar), 2019 (Race in Education, edited by Gerhard Mar), and 2020 (Persistence of Race, edited by Nina G. Jablonski) contain the complete representation of the projects scholarship.

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How the dimensions of human inequality affect who and what we are - The Conversation CA

How To Self-Massage To Relieve Muscle Tension And Stress – Longevity LIVE

Self-massage is a wonderful tool to use if you need to release a bunch of muscle tension. Were living in a very stressed and tense world right now and its important to learn how to self-soothe. If you cant get to a massage therapist at the moment due to financial problems or Coronavirus. Then, learning to knead those tight knots out on your own, or with your partner will help you big time. We could all use a helping hand right now and we thought we could help you relax those tense muscles with these tips.

It might seem like human toughness is a luxury at the moment. With social distancing rules strictly in place, were not allowed to do much touching at all. This can take its toll on us all, in more ways than you might think. Self-massage is a really powerful tool to help get you through even the most stressful of times. Of course, self-massage is not as nice as having a professional do it for you, but you might enjoy the connection and time you spend taking care of yourself. These are tough times and we need to nurture ourselves and practice self-care more than ever before.

Interestingly, the human touch is not just something we enjoy sometimes. Its a biological necessity and we need it to survive. Touch is the very first sense we develop as babies. If an infant is starved of touch it will fail to meet growth standards. Therefore, we are trying to tell you just HOW powerful a tool it is.

According to massage experts, touch builds cooperative relationships and improves immunity. So any form of touch can help increase pleasure hormones and reduce stress hormones. However, self-massage is an especially effective tool particularly during times when you have to be alone or cautious about touching one another. But knowing exactly how to self-massage will be most effective. Moreover, it can relieve muscle tension created by physical and emotional stress, which will improve the health of our bodies and minds.

Finding ways to progressively relieve muscle tension is a life-changer you cant miss out on. We cannot emphasize enough how important it is for your health to manage your stress and anxiety. If youve been experiencing intense backaches, neck pain, or shoulder tightness, youre most probably suffering from anxiety or stress. You see, when youre really anxious or stressed in your life, it can manifest physically as a direct symptom. The body automatically responds to this with muscle tension. However, self-massage can be done in a variety of different ways, youve just got to learn what works best for you.

Experts also recommend progressive muscle relaxation as a method that helps relieve intense muscle pain. They explain that progressive muscle relaxation is where you tense a group of muscles as you breathe in, and you relax them as you breathe out. You work on your muscle groups in a certain order. The trick is to relax your body fully because it will then no longer feel anxious. But you need to practice this regularly for a few weeks to get better at this skill. With some time, you should be able to self-massage and relieve some stress and tension on your own.

In the beginning, you might find it easier to follow some self-massage tutorial videos on YouTube or an audio recording. You need to learn all the major muscle groups. When searching, have a look for progressive muscle relaxation audio recordings. Self-massage is also a good way to help you remedy poor sleeping patterns at night.

There are usually many reasons why we have giant knots in our backs or necks. However, for many people it is often a combination between too much stress and poor posture. Very few of us have perfect posture. Whether you sit or stand during the day. In fact, those of you who work on your feet often stand swaybacked.

This is why self-massage and knowledge are really going to make a big difference. Then those of us who work at desks push our heads forward and hunch our shoulders. We then sit so long that our hips become tight. And over time, our muscles get stuck in the memory of those positions.

However, as we mentioned its not only your posture creating these knots. Your muscles remember emotions almost too well. It is a natural reaction for our muscles to contract when we stress to protect us from harm. But then when the threat disappears, our muscles let go. Chronic stress is when the muscles can never relax. And without self-massage, prolonged chronic stress leads beyond discomfort to physical and mental disorders.

Experts explain that a muscle knot is a trigger point. Moreover, its a contraction within a muscle that refuses to release. Sometimes the pain is localized to one area or it can radiate to other parts of the body. For example, a trigger point in a neck muscle you dont feel may be responsible for the pain in your jaw you do feel. The good news is that, through self-massage, we can release trigger points before our bodies start compensating elsewhere.

Often we think we cant get a massage in when nobody is willing to do it for us. Or many, your partner isnt near or maybe you dont have one right now. Thats okay because self-massage will take care of it for you. You can press on or roll your trigger points with your fingers, knuckles, or a tennis or massage ball. Its a little bit of work for yourself, but trust us when we say, its totally worth the effort.

Just try not to spend more than five seconds on one spot, because this cuts off blood flow and prevents healing.

Lets define one muscle at a time.

Most of us experience some kind of neck pain on our journeys. Self-massage is a fantastic way to help relieve this tension whenever you need it.

Do you experience chronic headaches? Experts recommend examining your sternocleidomastoids, the ropy neck muscles that extend from just behind the ear to the collarbone. Apparently, looking down at a keyboard or screen creates trigger points on the muscle which then refers pain into the forehead, ears, or cheeks.

To self-massage, gently pinch the muscle between your thumb and forefinger and roll it like a piece of taffy. Work your way up the entire rope.

This part of you can get completely locked up, tense and painful. After a while, it results in a that travels from the neck into your shoulders. These are called your levator scapulae, or shoulder-shrugger muscles.

If you need to self-massage these, then wrap an arm around yourself to touch the top inside corner of your opposite shoulder blade. Press on the knots and roll back and forth with your fingers. Or place a ball between your shoulder and a wall to dig deep into these trigger points.

A lot of emotions are held within our chest region, as this is where the heart chakra lies. Therefore, its very important to love and not neglect this part of our bodies.

In fact, when your body is seated with rounded shoulders for long periods of time, the pectoralis major muscles collapse and grow tight. This can potentially cause shortness of breath or pain in the front of the shoulder and down the inside of the arm.

To self-massage these muscles, run your fingers or knuckles just below your collarbone from the center outward. Try to move away from the space where you feel a pulse. Or, while standing, pin a ball between your chest and the wall with your arm outstretched to roll out this area.

Now we know this part of our bodies can get really sore. You need to self-massage this area gently.

If youre standing at a counter or at a desk without your core engaged, you may feel pain in your lower back or buttocks. The source could be a trigger point in your quadratus lumborum, two muscles that sit on either side of your spine between your pelvis and your lowest rib.

Try to self-massage by lying on the floor with your knees bent. Secure the ball on your lower back and gently roll over tender spots.

We hold a significant amount of muscle tension and soreness in our buttocks.

Often the pain in your lower back is emanating from trigger points in your buttocks. To get into the meaty gluteus maximus muscles, sit on a ball and roll in all directions.

Try to self-massage by leaning back to roll just below the hip bone. For more pressure, prop the foot to the side you are rolling out on the opposite knee (figure four position).

If you allow your body to stress and hold too much tension in the calves, then you will cause the muscles in your feet to knot up. Its important you take time to self-massage by pressing your fingersinto the arch of your foot.

You can also self-massage by rolling on a golf ball youve chilled in the freezer. If left untreated, these knots can lead to a type of tendinitis in the foot called plantar fasciitis.

We store a lot of emotional stress in our feet too, which is why going barefoot on some grass or in your garden really helps us ground and relax. Give it a try.

And if youre fortunate enough to have a partner then communicate with them. Learn to give each other massages, because its not always ideal to self-massage. Besides, its good to help relax one another. Giving a massage isnt just a nice thing to do; it can also decrease anxiety for the giver.

If you are going to give each other a massage then make sure you get feedback from your partner or housemate. You dont want to be too aggressive or too gentle. Start by asking, Do you want more pressure or less? Massage experts recommend using broad strokes with the palm of your hand and moving in one direction. But ideally, you want to move toward the heart. Its also a plus to add a drop of lotion or oil to your hands to improve glide.

Gritty strength is probably the one most important character traits we need to develop right now. 2020 has by far been one of the most trying and challenging years of them all. Find out how to focus on developing grit.

Knead those knots away. Washington Post. https://www.washingtonpost.com/graphics/2020/lifestyle/wellness/how-to-give-a-massage/

Stress Management: Doing Progressive Muscle Relaxation. Michigan Medicine. https://www.uofmhealth.org/health-library/uz2225

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How To Self-Massage To Relieve Muscle Tension And Stress - Longevity LIVE

Understanding the Population Problem | Earth 911 – Earth911.com

When the global population reached 5 billion in 1987, that number seemed almost inconceivable. But today, there are almost 8 billion people on the planet and by 2056, we could reach 10 billion humans. Without technical innovation and changes in human behavior, Earths ecosystems may not be able to support that population.

Many people think that overpopulation is a problem that belongs to developing nations, where the population is increasing most rapidly. But the question of population is not so simple. The sustainability of society is intricately linked with issues of consumption, sustainable development, and human rights.

Even those of us in countries with low or negative population growth can make a difference.

Anyone who has taken an introductory biology or economics course can recognize the steeply rising curve in the global population graph. It represents an unsustainable growth pattern.

The question is, at what point will we reach the planets carrying capacity? At what population will we outstrip the resources available to support us? And can we expand the carrying capacity of the planet with technology and changes to our lifestyles? That, in large part, depends on how efficiently we use our resources.

The annual ability of Earths natural systems to replace used resources is decreasing as a result of desertification, climate change, and other human land use impacts. At the same time, we are using those resources faster than ever.

At U.S. consumption rates, based on a per capita footprint of 9.8 global hectares per person (gha), the current global population would overshoot each years worth of natures bounty by March 15. That means that the planet could not sustain its current population or even a third of it if everyone on Earth consumed resources like we do in the U.S.

Chinese consumers use resources at less than half the rate of Americans (3.6 gha) and much of their resource extraction is used to make products for American consumption. But with a population of 1.4 billion, their total consumption is much greater overall.

The same over-consuming pattern is evident in greenhouse gas emissions on a national basis a few countries account for the overwhelming majority of annual CO2 emissions. These emissions contribute to climate change, which further degrades the Earths ability to support life.

The number of people and their per capita consumption and greenhouse gas emissions matter equally in achieving a sustainable population.

The impacts of land use, resource consumption, greenhouse gas emissions, and population are connected in complex ways that can form self-reinforcing feedback loops. In 1989, the United Nations established July 11 as World Population Day in an effort to focus attention on the urgency and importance of population issues.

International migration can have significant impacts on the populations of individual nations. The two factors that determine the global population are fertility rates and longevity. The management of each of these factors is rife with thorny ethical issues. Historically, high mortality kept population growth in check. Moving forward, we must turn our attention to fertility rates to slow population growth.

The United Nations Population Fund (UNFPA) was established in 1969 to promote U.N. and national population programs. These programs are based on the human right of individuals and couples to freely determine the size of their families. The gender and human rights dimensions of population issues are recognized in the three key areas of the UNFPA mandate: reproductive health, gender equality, and population and development.

Reproductive rates are much smaller in the most developed nations, but the reproductive choices made in these countries have an outsized impact. One person born in America has the same environmental impact as two in China, and nearly seven in India. Choosing to have a small family is one of the most impactful things an American can do to protect the environment.

However, it is far from the only thing. Americans and residents of other developed nations must learn to consume fewer resources and reduce their carbon footprint. They can welcome and support refugees and immigrants, whose arrival can rebalance host countries potential support ratio (PSR). The PSR is the ratio of the working-age population to the elderly population. In developed nations, the PSR has declined to record lows from about eight in 1950 to slightly more than three today, leaving many economists as deeply concerned about population decline as environmentalists are about overpopulation.

Developed nations can support the U.N.s nine standards to uphold the human right to family planning including nondiscrimination, privacy, and access to information and contraception in both domestic policy and in foreign aid programs.

Finally, the ongoing pandemic has highlighted the importance of gender equality in achieving all of the United Nations goals. Protecting the health and rights of women everywhere leads to better outcomes. Thats as true for land use, resource consumption, and greenhouse gas emissions as it is for population control.

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Understanding the Population Problem | Earth 911 - Earth911.com

How AI is uncovering the ‘dark matter of nutrition’ – World Economic Forum

The COVID-19 pandemic didnt just transform how we work and communicate. It also accelerated the need for more proactive health measures for chronic health problems tied to diet. Such problems have emerged as a top risk factor for coronavirus and people with poor metabolic health accounted for half of COVID-19 hospitalizations in some regions around the world. The resulting high numbers led the authors of a report in The Lancet to issue a call for more resources to tackle metabolic health to avoid needless deaths.

Thankfully, new tools have been developed to offer comprehensive understanding of nutrition. This expertise and technology wont just help us tackle metabolic health it could help us finally fully realize the power of plants to improve health and wellness outcomes.

The first global pandemic in more than 100 years, COVID-19 has spread throughout the world at an unprecedented speed. At the time of writing, 4.5 million cases have been confirmed and more than 300,000 people have died due to the virus.

As countries seek to recover, some of the more long-term economic, business, environmental, societal and technological challenges and opportunities are just beginning to become visible.

To help all stakeholders communities, governments, businesses and individuals understand the emerging risks and follow-on effects generated by the impact of the coronavirus pandemic, the World Economic Forum, in collaboration with Marsh and McLennan and Zurich Insurance Group, has launched its COVID-19 Risks Outlook: A Preliminary Mapping and its Implications - a companion for decision-makers, building on the Forums annual Global Risks Report.

The report reveals that the economic impact of COVID-19 is dominating companies risks perceptions.

Companies are invited to join the Forums work to help manage the identified emerging risks of COVID-19 across industries to shape a better future. Read the full COVID-19 Risks Outlook: A Preliminary Mapping and its Implications report here, and our impact story with further information.

We know that plants are critical for health, but do not fully understand why. Humans have not mapped the breadth of what plants offer, nor have we pinpointed the specific biological mechanisms of action triggered in our bodies when we eat them. This knowledge gap exists at the molecular level, with a need to understand how phytonutrients tiny plant molecules with anti-inflammatory, cardioprotective and neuroprotective properties work in our bodies. In fact, the scientific community refers to the vast world of phytonutrients as the dark matter of nutrition because less than 1% of these molecules have been catalogued to date. The opportunity to learn more about phytonutrients and further tangibly connect their impact to health is massive.

Technologies, such as Artificial Intelligence, are helping researchers learn more about the biological connections between plants and humans. For instance, Brightseed has created a powerful artificial intelligence called Forager, which coupled with advanced metabolomics instrumentation, systematically identifies unknown plant compounds and predicts their likely roles in human health. Thus far, the technology has predicted beneficial phytonutrients for many important health conditions.

Recently, in collaboration with leading biomedical researchers, Brightseed discovered a powerful phytonutrient with the potential to improve metabolic health. This phytonutrient helps restore proper function of a central metabolic regulator, including maintaining healthy lipid and sugar levels in the bloodstream and key organs such as the liver, whose function is impaired by a poor diet. Brightseed will start clinical studies on this phytonutrient before the end of this year.

The impact of this discovery could be wide reaching and have profound implications for more than two billion people worldwide at elevated risk of chronic metabolic diseases. Elevated levels of fat in the liver (which are directly caused by chronic overeating) afflict between 25% and 30% of the global population. These individuals with fatty liver disease are 57% more likely to die prematurely and much more like to develop other debilitating metabolic diseases, including diabetes. The discovery of this phytonutrient is a glimpse into the positive change deeper nutritional understanding could bring.

Just as 1918 pandemic led to creation of the modern medicine industry, we now are at a similar tipping point with nutrition, on the precipice of developing a much more complete understanding of how plants are connected to human health.

The first step is improving our foundational knowledge. In the U.S., there is a broad-based effort among leading academic, non-profit and industry stakeholders to create a National Institute of Nutrition (NIN) to accelerate nutrition science and uncover the role of human nutrition in improving public health and reducing disease. The NIN, similar to institutes that exist in other countries, can support and incentivize higher-quality, more rigorous nutrition research at the molecular level. This research will provide a stronger foundation for nutrition recommendations and guidelines, which is essential to developing consensus in both the scientific and consumer communities.

The second step is a mindset shift. Modern food and agricultural systems have largely focused on - and solved - the problem of food insufficiency. However, preventable diet-driven chronic diseases have emerged instead. We need to pivot from merely increasing the supply of food to leveraging technologies that can help improve the nutritional quality of what we consume.

"We need to pivot from merely increasing the supply of food to leveraging technologies that can help improve the nutritional quality of what we consume."

Healthier food options can be the center of a new proactive health industry and provide the food industry the opportunity to make important contributions to health and longevity, while benefiting economically from the capture of existing healthcare investment that currently is directed to treating chronic disease. Our current treatment-focused healthcare system is increasingly unaffordable and poorly suited to addressing the needs of individuals at heightened risk of developing chronic diseases that are largely preventable through lifestyle modifications, especially those related to diet.

No changes will be possible without forging new collaborations between public and private entities. Through cooperation we can develop more nutritious options and greatly influence policy change. Partnerships are also how well create a more nourished world and maximize our impact.

For the first time, we have the tools to explore the plant kingdom at the molecular level and answer questions such as How does what we eat really affect us? or How can food become medicine?

Technology is exponentially improving our understanding of how plants are connected to health. Together, we can goal shift the healthcare model from one squarely focused on treatment of disease to one that promotes health and natural resilience.

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How AI is uncovering the 'dark matter of nutrition' - World Economic Forum

White sneakers that won’t get ruined on their first use – CNN

Without fail, my wardrobe gets one major criticism from friends, family, loved ones and nosy house guests: Why do you need so many pairs of white sneakers?

Ive counted 15 pairs of white sneakers in my closet. And if you think thats a lot, heres a tidbit: I owned even more a few months ago, prior to moving out of the country and being forced to wisely pick and choose footwear.

The simple answer to the question is: You dont need that many white sneakers, but theyre a difficult product to vet before buying. Options may seem well and good online or even in the store, but after a month of wearing them, they get dirty beyond recognition or you realize that theyre too uncomfortable to wear on a daily basis. As someone whose main sartorial statement is white sneakers, I tend to go through a lot of pairs, only to settle for a few that actually stand the test of time.

Allbirds Wool Runners PHOTO: Allbirds

See, for the uninitiated in the sneaker world, every white sneaker may seem the same. But the truth is, there are huge discrepancies across brands, styles, materials and construction that make some pairs more attractive than others. Breathability, longevity, comfort and overall style have to be considered before you buy just any plain old white sneaker.

Its why all three factors were in the selection of the six pairs below. Each have been worn for at least a year, with many being worn well beyond that time frame. Additionally, all of the footwear on our list has gone through some sort of cleaning cycle, whether through a machine wash or through hand cleaning, depending on the materials. (Pro tip: Baking soda and water usually do the trick, but if you want to be buttoned up, Jason Markk makes a handy shoe cleaning kit thats worth checking out).

The result? All six of these footwear options surpassed expectations when it came to durability (both in terms of construction and overall color), ease of cleaning and aesthetic.

Adidas Stan Smith Shoes ($80 for women; adidas.com and $80 for men; adidas.com)

There are reasons why Stan Smiths have been in the fashion zeitgeist the past few decades: Theyre equal parts fashion-forward, comfortable and long-lasting. Its no surprise they ended up being our absolute favorites.

Where the Stan Smiths truly impress is their level of durability. After 18-plus months of wearing, Im continuously amazed by their ability to hold up. While the toes and the soles have scuff marks here and there, to the naked eye, it only looks like a few months worth of wear and tear instead of a few years worth. More noteworthy is the fact that unlike other leather sneakers that Ive owned, theres no noticeable cracking on the surface.

Adidas Stan Smiths Shoes PHOTO: Adidas

No sneaker is without its flaws, however. As someone with particularly high arches and therefore subject to an excruciating break-in period on most shoes I found that these dont have as much support as some of the other options on this list. Youll want to break the shoes in before you start clocking serious miles with them.

However, the biggest issue Ive noticed over the past months is that this design lacks ventilation holes, especially compared with the other options on our list. As a result, my feet can feel overheated, especially during the warmer seasons. While these two issues are ones Im willing to accept for the benefit of the shoes longevity, if youre looking for a more summer-friendly shoe, Id suggest you scope out the breathable options below.

Cole Haan Generation Zerogrand Stitchlite ($120; colehaan.com, zappos.com, nordstrom.com)

Cole Haan Generation Zerogrand Stitchlite

After selling nearly 3 million pairs of its Zerogrand sneakers, its safe to say that Cole Haan has design down when it comes to footwear.

The Generation Stitchlite comes with the brands signature sole support and comfort, something that proves to be a real godsend when you break in your shoes. The Stitchlite, in particular, ups the ante by providing a springy arched outsole, as with as comfortable insoles that help mimic the motions of the human foot.

This hasnt gone unnoticed during my time wearing them. Among the biggest benefits of these shoes is how quickly they have conformed to my feets natural curvature and shape. While Id by no means place them in the performance category, its worth noting that their shock absorption wont take a toll on your feet during long walks or a hectic day of errands.

Cole Haan Generation Zerogrand Stitchlite PHOTO: Cole Haan

In many ways, I treat them as slip-on sneakers (thanks to their innovative lacing system and stretchy material, which makes them easy to pop on and run out of the door). They also happen to be among the brands lightest sneakers to date, with a perforated, stitched design that makes them completely breathable. Plus, I find the perforated detailing an on-trend addition to my athleisure outfits, and it gives more texture to an otherwise boring sweatshirt and leggings combo.

Rothys The Sneaker ($125; rothys.com)

For those who want a real slip-on sneaker (as opposed to the aforementioned Cole Haan pair that acts like one), its hard to beat the comfort, look and feel of Rothys The Sneaker. Its the comfiest slip-on shoe Ive ever owned, period. Scratch that, its the comfiest shoe Ive ever owned.

This is due in large part to its soft-to-the touch, moisture-wicking fabric. Unlike its canvas counterparts, Rothys The Sneaker isnt made with tough materials that lead to blisters and scratches. Theres no need for band aids or insoles when you break in these shoes. Heck, theres no need for socks, either. I find theyre completely comfortable straight from the box. Plus, it gets bonus points for the fact that its insoles are crafted from recycled water bottles.

These also happen to be among the rare group of white sneakers I own that can stand up to a wash cycle, so long as you pop out the insoles and wash them both on a cold cycle (and air dry after). The color stays relatively vibrant.

Even more impressive is the fact that after a year and a half of constant use, both the soles and the insoles are perfectly intact. If I retire these shoes before the two-year mark, Id be shocked. Thats saying something.

Allbirds Wool Runners ($95; allbirds.com)

Many of us are making conscious strides to be eco-friendlier. We take reusable bags to the grocery store, carpool as often as we can and invest in brands that are doing social and environmental good in the world. Allbirds is no exception.

The company utilizes materials from a variety of ethically sound and environmentally friendly sources, including Merino wool from sheep farmers who are held to high standards of land practices and animal welfare.

Among its most popular sustainably sourced designs are its Wool Runners. These machine-washable sneakers are crafted from renewable materials, as well as moisture- and odor-wicking fabrics that make it possible to wear them without the constant need for socks (although I still suggest opting for no-show socks with these shoes).

Allbirds Wool Runners PHOTO: Allbirds

Theres no denying the comfort and cool factor that come with these shoes. And since all white sneakers get dirty (its an unfortunate fact of life), its amazing to have the ability to throw them in a wash cycle instead of scrubbing them with a toothbrush.

However, while I love the look and feel of my Allbirds, Id say proceed with caution: Ive noticed the wool loses its luster after multiple wash cycles. So, to prevent that, Id advise against wearing these where you could get them particularly dirty and need to throw them in the wash over and over again (festivals, trail walks, you name it).

Superga Cotu Sneaker ($48.75, originally $65; zappos.com or $64.92; amazon.com or $65; anthropologie.com)

The overall quality of the materials of the Superga Cotu Sneakers is immediately noticeable. This design features a cotton unlined canvas upper, a rubber sole for added traction and a very-on trend platform thats about an inch high. The canvas, in particular, strikes the ideal balance between durable and comfortable, and the sole is by far the grippiest of the designs on this list. And thanks to the elevated platform, most of the scuffs and marks are concentrated at the sole of the shoe, rather than becoming noticeable blemishes on its most visible areas, like the toe.

Superga Cotu Sneaker PHOTO: Anthropologie

The biggest selling points include its roomy design thats ideal for those with wider feet (aka, me) as well as a refined, simple aesthetic that Ive found elevates my classic jeans-and-tee errands outfits.

And while these are relatively easy to spot clean and then throw into the wash, shoppers should keep in mind that canvas tends to show its age. While still durable, these sneakers may not stand the test of time in the same ways that the Stan Smith do.

Greats Royale Knit ($119; greats.com)

Im a big proponent of knit sneakers. This is all thanks to their flexibility and pliability that makes them a more comfortable alternative (especially for those with wider feet) to leather options.

During warmer months, I swap my Stan Smiths with the Greats Royale Knit, which are much more breathable. You wont feel overheated or uncomfortable running or walking miles in them. Plus, styling them with practically any outfit is a breeze.

They can take a beating and come out of the wash looking brand new. Its everything youd want in a pair of shoes youre wearing seven days a week.

Like Rothys, the Greats Royale Knits are also made responsibly, and are crafted from 100% vegan, recycled plastic (one pair helps eliminate seven plastic bottles from the ocean). And like many of the knit options here, theyre incredibly comfortable to wear, although youll definitely need to wear socks with them. While they could benefit from extra support, I find its enough to help me get through an entire day on my feet.

The biggest benefit is the fact that these shoes are machine washable and that the fabric doesnt hold onto stains as much as others on our list. If you get caught in a shower or accidentally step into a muddy puddle, as I have done on multiple occasions, theres not much to worry about.

Best of all, $15 from every sale is being donated to the NAACP.

Note: The prices above reflect the retailers listed price at the time of publication.

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White sneakers that won't get ruined on their first use - CNN

Ingredient Spotlight: Reishi Mushroom, a Superfood that Helps Everything from Your Heart and Blood Pressure to Immunity – One Green Planet

Reishi mushroom is all over the health world. Most likely, youve seen it stamped across a tin of mysterious superfood powder in the health aisle or listed as an ingredient in your new tincture or elixir. So, whats up with reishi mushroom and why is it so friggin popular?

Well, obviously, reishi mushroom is well a mushroom, but it happens to be one thats got quite a long lineage. In fact, reishi mushroom has been noted in ancient and alternative medicines thousands of years old. This fungi has some powerful health benefits and also happens to be high in those body-loving antioxidants.

Lets take a deep dive into this wonderful ingredient!

tassilo111/Pixabay

Alright, reishi mushroom is a mushroom, but where does it come from and how are you supposed to consume it?

Reishi mushrooms referred to asGanoderma lucidum are most commonly used in Eastern medicines and have been used in traditional medicine practices for more than 2,000 years. As popular as these mushrooms have become in the western world, theyre actually quite rare, growing at the base of deciduous trees, preferring various hot and humid locations in Asia.

As is similar to most plant-based foods, reishi mushrooms contain dietary fiber and various minerals, vitamins, and amino acids, yet what makes these little fungi so special is there high content of polysaccharides, peptides, and triterpenoids, which may be linked to their positive health effects. The most common way of consuming reishi mushroom is in powder form, a dried mushroom that is ground into a powder as well as in supplements, but you can also find reishi mushroom in teas, herbal tonics, elixirs, and tinctures. Of course, if you can get your hand on safely foraged, cleansed, and packagedreishi mushroom, then you can actually consume the mushroom itself.

Theres a reason our forebearers relied on reishi mushroom for many of their alternative medicines. Theres also a good reason why its had a resurgence in the western world. This mushroom is used in superfood mixes and health-boosting tinctures and elixirs due to its powerful health benefits. From giving your immune system and energy supply a boost to increasing heart health and leveling blood sugar levels, reishi mushroom pretty much does it all.

While human studies are limited, there are a few to note that illuminate the positive health powers of this mushroom!

When it comes to boosting your immune system, there are a few studies that have shown how reishi mushroom effects white blood cells, which are critical parts of your immune system.

A study performed in the School of Basic Medical Sciences at Peking University Health Science Center entitledCellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum the scientific name for reishi mushroom found that the immuno-modulating effects of G. lucidum polysaccharides were extensive, including promoting the function of antigen-presenting cells, mononuclear phygocyte system, humoral immunity, and cellular immunity.

On top of that, another study performed at Clemson University here in the U.S. entitled The effects of two different ganoderma species (Lingzhi) on gene expression in human monocytic THP-1 cells found that some forms of reishi may alter inflammation pathways in white blood cells.

With that said, its important to note that both of these studies were performed on those that were already ill. While more research is necessary to substantiate the claim that reishi mushroom boosts the immune system of healthy people, its obvious that the natural agents in the mushroom have a positive effect on those immune system-crucial white blood cells.

The anti-cancer properties of reishi mushroom was slightly touched upon in the studies performed on the immune system, yet theres definitely more to the story.In fact, there are several non-human, test-tube studiesthat have shown that [reishi mushroom consumption] can lead to the death of cancer cells.

The most aggressive evidence for reishis cancer-fighting properties was done in a study at the Hiroshima University Hospital in the Department of Endoscopy entitledA water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas.The study looked at reishis role in preventing or fighting colorectal cancer and found that one year of treatment with reishi decreased the number and size of tumors in the large intestine.

Studies have also found that reishi mushroom may have overall positive benefits for cancer patients including increasing the activity of the bodys white blood cells, which help fight cancer, and improving quality of life in cancer patients.

While reishi mushroom isnt necessarily proven toboost energyit has been well documented to have fatigue-fighting effects.There are two studies in particular that show the fatigue-fighting effects of this mushroom.

The first study performed at the New Zealand Institute of Natural Medicine Research entitled A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia, examined [reishi mushrooms] effects in 132 people with neurasthenia, a poorly defined condition associated with aches, pains, dizziness, headaches and irritability and found that fatigue was reduced and well-being was improved after [eight] weeks of taking the supplements.

The second study performed at theThird Affiliated Hospital of Harbin Medical University entitledSpore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial found that fatigue was reduced and quality of life was improved after [four] weeks of taking reishi powder in a group of 48 breast cancer survivors.

Cardiovascular health is one of those burgeoning issues that were finding is linked to a variety of other health concerns. Therefore, its more important than ever to make sure youre keeping your heart as healthy as possible!

A small 26-person, a 12-week study performed by the Department of Medicine and Therapeutics at the Chinese University of Hong Kong entitled Study of potential cardioprotective effects of Ganoderma lucidum found that reishi mushroom may increase good HDL cholesterol and decrease triglycerides a type of fat (lipid) found in your blood that are used as energy both of which are indicators of overall heart disease risk.

Blood sugar is linked to a variety of health issues and is also a large indicator of diabetes risk. Much like heart health, its incredibly important to keep blood sugar levels balanced, level, and healthy.

A few studies have shown that reishi mushroom may contain molecules that decrease blood sugar. The human-based studies are preliminary, yet one study published in theInternational Journal of Medicinal Mushroomsdid find some effects of blood sugar regulation in humans.

While a few studies are promising, far more research is necessary to really unravel the mysterious connection between reishi mushroom and blood sugar control.

sweetlouise/Pixabay

While reishi mushroom is known for its health benefits, its also a mushroom meaning its got a toxic component to it, and its known for some unwanted side effects including a few non-urgent such as an upset stomach, skin rashes, and nausea and some very urgent such as liver damage and liver toxicity, chronic diarrhea, blood stool, and nose bleeds.

The issue arises that most of the human-based evidence for reishi mushroom centers around traditional medicine records that are thousands of years old. This makes dosage a bit of a difficult hurdle.

For instance, the Susan G. Komen Foundation notes that reishi mushroom extract is possibly safe for up to [one] year when a person takes it orally. On the other hand, taking powdered reishi mushroom for longer than [one] month may be toxic to the liver. When it comes to dosage, it all depends on the specific product and, of course, your individual bodily needs. Yet, with the risk of liver toxicity, its incredibly important to make sure youre taking this mushroom correctly.

The best way to moderate your reishi mushroom intake is to team up with a health professional of your choosing, whether thats an herbalist, naturopath, dietitian or nutritionist, or your medical doctor. Not only will these professionals be able to moderate how the substance is affecting your body, but they can also be a guide to help you with any challenges your face with reishi mushroom.

Alright, youve spoken with your medical professional and gotten the go-ahead to give reishi mushroom a try, so no what? When looking for a product, first decide how you want to consume the mushroom. Are you a protein shake junkie? Is a simple supplement the easiest? Do you want to give a tincture or elixir a whirl? Once you figure out the method, make sure to look for products that have been certified with care such as certified USDA organic, non-GMO project verified, and, of course, vegan!

Four Sigmatic Reishi Mushroom Elixir/Amazon.com

Four Sigmatic happens to be one of the leading health food supplements when it comes to getting those mysterious and powerful mushrooms into your body safely! This Four Sigmatic Reishi Mushroom Elixir provides a 1,500-milligram dose of organic reishi mushroom to support sleep and promote stress relief. This unique blend incorporates the adaptogen tulsi for stress relief and rose hips and mint for a bit of delightful flavor. This product is vegan, keto, and Whole30-friendly, certified USDA organic, sources its ingredients from natural farms or wild harvesting and is free of carriers, fillers, artificial flavors. One 20-count box costs $21.80.

Micro Ingredients Sustainably US Grown Organic Reishi Mushroom Powder/Amazon.com

If you absolutely love those east-to-make and on-the-go shakes packed with nutrients and energy, then powder reishi is definitely the way to go! This Micro Ingredients Sustainably US Grown Organic Reishi Mushroom Powder offers a 100:1 extract to support a strong cardiovascular system, boost energy endurance, and aid in stress relief. This product is sustainably grown here in the U.S., is certified USDA organic, non-GMO, and contains no additives, preservatives, fillers, or artificial colors. Along with being vegan, this product is also gluten-free! An 8-ounce package costs $23.95.

New Chapter Reishi Mushroom Supplement/Amazon.com

Supplements are probably the easiest way to go when youre trying to get all the nutrients necessary for a healthy body! You can pop them in your purse, hide them in a medicine cabinet, and travel easy. This New Chapter Reishi Mushroom Supplement is not only organic but also 100 percent certified vegan, non-GMO project verified, certified kosher, and gluten-free. This reishi blend aims to support healthy aging by maintaining vitality, longevity, and wellness. A 60-count bottle costs $17.09.

Herb Pharm Reishi Mushroom Liquid Extract Immune System Builder/Amazon.com

Tinctures are a great way to receive a potent dose of those hard to get ingredients that you cant quite cook with. With that said, its always a good idea to be on the lookout for unsafe tinctures, as theyre not highly regulated by the government. This Herb Pharm Reishi Mushroom Liquid Extract Immune System Builder is created by highly-trusted, Oregon-based Herb Pharm, known for their high-quality products. This product is vegan-friendly, certified USDA organic, gluten-free, and non-GMO. The liquid tincture allows for rapid absorption into the body and focuses specifically on building the strength of your immune system. A 1-ounce bottle costs $14.05.

Traditional Medicinals Organic Reishi Mushroom with Rooibos & Orange Peel Herbal Tea/Amazon.com

One of the most popular ways to consume reishi mushroom is via a beverage. Tea is a comforting ritual that you can integrate into your daily routine as a moment of reflection, peace, or simple relaxation. This Traditional Medicinals Organic Reishi Mushroom with Rooibos & Orange Peel Herbal Tea supports the immune system through a blend of sun-kissed citrus earthy notes. This product is non-GMO verified, certified organic, kosher, and caffeine-free. Go bulk with this one! A 6-box pack (16 tea bags apiece) costs only $25.81.

We also highly recommend downloading ourFood Monster App, which is available foriPhone, and can also be found onInstagramandFacebook. The app has more than 15,000 plant-based, allergy-friendly recipes, and subscribers gain access to new recipes every day. Check it out! For more Vegan Food, Health, Recipe, Animal, and Life content published daily, dont forget to subscribe to theOne Green Planet Newsletter! Being publicly-funded gives us a greater chance to continue providing you with high-quality content. Pleasesupport us!

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Ingredient Spotlight: Reishi Mushroom, a Superfood that Helps Everything from Your Heart and Blood Pressure to Immunity - One Green Planet

NeoGenomics Reports Revenue of $87 Million in the Second Quarter amid COVID-19 Pandemic – Stockhouse

Second-Quarter 2020 Results and Highlights:

FORT MYERS, FL / ACCESSWIRE / July 28, 2020 / NeoGenomics, Inc. (NASDAQ:NEO) (the "Company"), a leading provider of cancer-focused genetics testing services, today announced its second-quarter results for the period ended June 30, 2020.

"As expected, second quarter financial results were challenging due to the global COVID-19 crisis, which reduced both revenue and earnings," said Douglas M. VanOort, Chairman and CEO of NeoGenomics.

"Even in the midst of this pandemic, we made several strategic moves and invested in our business. We fortified our balance sheet with a successful offering of both common stock and convertible securities, we strategically invested in Inivata for access to liquid biopsy and minimal residual disease testing capabilities, we launched a suite of liquid biopsy tests, we moved forward with investments to further globalize our Pharma Services business, and we built and operationalized a high-capacity COVID-19 testing laboratory. We believe these investments will deliver both near-term and long-term growth, and that we exited the second quarter in a stronger competitive position for the future."

Second-Quarter Results

Consolidated revenue for the second quarter of 2020 was $87 million, a decrease of 14% over the same period in 2019. Clinical Services revenue decreased year-over-year by 17% to $74 million driven by a clinical test volume(1) decrease of 18%. Average revenue per clinical test ("revenue per test") remained stable at $351. Pharma Services revenue grew by 3% to $13 million compared to the second quarter of 2019, primarily due to the January 10, 2020 acquisition of the Oncology Division assets of Human Longevity, Inc. ("HLI - Oncology"). While disruptions in volume stemming from the COVID-19 pandemic reduced growth in both Divisions, there was steady improvement throughout the quarter.

Gross profit was $28.0 million, a decline of 42.8%, compared to the second quarter of 2019. This reduction was the result of the combined effect of lower test volume due to the impact of the COVID-19 pandemic and our decision to retain employees.

Operating expenses increased by $2 million, or 5%, compared to the second quarter of 2019, reflecting investments in informatics, growth initiatives and costs associated with the integration of HLI - Oncology.

Net loss for the quarter was $7 million compared to net income of $2 million for the second quarter of 2019.

Adjusted EBITDA(2) was negative $7 million for the quarter compared to positive $15 million in the second quarter of 2019. Adjusted Net (Loss) Income(2) was a loss of $4 million compared to income of $7 million in the second quarter of 2019.

Cash and cash equivalents, including restricted cash, was $331 million and days sales outstanding ("DSO") was 92 days at the end of the second quarter of 2020 due to the impact of COVID-19 and the distribution of revenue.

(1) Clinical tests exclude requisitions, tests, revenue and costs for Pharma Services and COVID-19 Polymerase Chain Reaction ("PCR") tests.

(2) The Company has provided adjusted financial information that has not been prepared in accordance with GAAP, including Adjusted EBITDA, Adjusted Net (Loss) Income, and Adjusted Diluted EPS. Each of these measures is defined in the section of this report entitled "Use of Non-GAAP Financial Measures." See also the tables reconciling such measures to their closest GAAP equivalent.

Conference Call

The Company has scheduled a webcast and conference call to discuss their first quarter results on Tuesday, July 28, 2020 at 8:30 AM EDT. Interested investors should dial (844) 602-0380 (domestic) and (862) 298-0970 (international) at least five minutes prior to the call. A replay of the conference call will be available until 8:30 AM EDT on August 11, 2020, and can be accessed by dialing (877) 481-4010 (domestic) and (919) 882-2331 (international). The playback conference ID Number is 35578. The webcast may be accessed under the Investor Relations section of our website at http://www.neogenomics.com. An archive of the webcast will be available until 08:30 AM EDT on October 28, 2020.

About NeoGenomics, Inc.

NeoGenomics, Inc. specializes in cancer genetics testing and information services. The Company provides one of the most comprehensive oncology-focused testing menus in the world for physicians to help them diagnose and treat cancer. The Company's Pharma Services Division serves pharmaceutical clients in clinical trials and drug development.

Headquartered in Fort Myers, FL, NeoGenomics operates CAP accredited and CLIA certified laboratories in Fort Myers and Tampa, Florida; Aliso Viejo, Carlsbad, Fresno and San Diego, California; Houston, Texas; Atlanta, Georgia; Nashville, Tennessee; and CAP accredited laboratories in Rolle, Switzerland, and Singapore. NeoGenomics serves the needs of pathologists, oncologists, academic centers, hospital systems, pharmaceutical firms, integrated service delivery networks, and managed care organizations throughout the United States, and pharmaceutical firms in Europe and Asia. For additional information about NeoGenomics, visit http://www.neogenomics.com/

Forward Looking Statements

Certain information contained in this press release constitutes forward-looking statements for purposes of the safe harbor provisions of The Private Securities Litigation Reform Act of 1995. These forward looking statements involve a number of risks and uncertainties that could cause actual future results to differ materially from those anticipated in the forward-looking statements as the result of the Company's ability to continue gaining new customers, respond to the effects of the COVID-19 outbreak, offer new types of tests, integrate its acquisitions and otherwise implement its business plan, as well as additional factors discussed under the heading "Risk Factors" and elsewhere in the Company's Annual Report on Form 10-K filed with the SEC on February 28, 2020. As a result, this press release should be read in conjunction with the Company's periodic filings with the SEC. In addition, it is the Company's practice to make information about the Company available by posting copies of its Company Overview Presentation from time to time on the Investor Relations section of its website at http://ir.neogenomics.com/.

Forward-looking statements represent the Company's estimates only as of the date such statements are made (unless another date is indicated) and should not be relied upon as representing the Company's estimates as of any subsequent date. While the Company may elect to update forward-looking statements at some point in the future, it specifically disclaims any obligation to do so, even if its estimates change.

For further information, please contact:

NeoGenomics, Inc.

William Bonello Director, Investor Relations (239) 690-4238 (w) (239) 284-4314 (m) bill.bonello@neogenomics.com

NeoGenomics, Inc. CONDENSED CONSOLIDATED BALANCE SHEETS (In thousands)

ASSETS

Cash and cash equivalents

Accounts receivable, net

Inventories

Other current assets

Total current assets

Property and equipment (net of accumulated depreciation of $80,143 and $68,809 respectively)

Operating lease right-of-use assets

Intangible assets, net

Goodwill

Restricted cash, non-current

Prepaid lease asset

Investment in non-consolidated affiliate

Other assets

TOTAL ASSETS

LIABILITIES AND STOCKHOLDERS' EQUITY

Accounts payable and other current liabilities

Short-term portion of financing obligations

Short-term portion of operating leases

Total current liabilities

Long-term portion of financing obligations

Long-term portion of operating leases

Convertible senior notes, net

Deferred income tax liability, net

Other long-term liabilities

Total long-term liabilities

TOTAL LIABILITIES

TOTAL STOCKHOLDERS' EQUITY

TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY

NeoGenomics, Inc. CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited) (In thousands, except per share amounts)

NET REVENUE:

Clinical Services

Pharma Services

Total revenue

COST OF REVENUE

GROSS PROFIT

Operating expenses:

General and administrative

Research and development

Sales and marketing

Total operating expenses

(LOSS) INCOME FROM OPERATIONS

Interest expense, net

Other (income) expense, net

Loss on extinguishment of debt

Loss on termination of cash flow hedge

(Loss) income before taxes

Income tax (benefit) expense

NET (LOSS) INCOME

NET (LOSS) INCOME PER SHARE

Basic

Diluted

WEIGHTED AVERAGE COMMON SHARES OUTSTANDING

Basic

Diluted

NeoGenomics, Inc. CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) (In thousands)

CASH FLOWS FROM OPERATING ACTIVITIES

Net loss

Adjustments to reconcile net income to net cash provided by operating activities:

Depreciation

Loss on disposal of assets

Loss on debt extinguishment

Loss on termination of cash flow hedge

Amortization of intangibles

Amortization of debt issue costs

Amortization of convertible debt discount

Non-cash stock-based compensation

Non-cash operating lease expense

Changes in assets and liabilities, net

Net cash (used in) provided by operating activities

CASH FLOWS FROM INVESTING ACTIVITIES

Purchases of property and equipment

Business acquisition

Acquisition working capital adjustment

Investment in non-consolidated affiliate

Excerpt from:
NeoGenomics Reports Revenue of $87 Million in the Second Quarter amid COVID-19 Pandemic - Stockhouse

Patience to Pay Off in Japan for a Loyal Aide – Bloomberg

Yoshihide Suga is patient. The longest-serving chief cabinet secretary in Japanese history, hes been a loyal aide in Prime Minister Shinzo Abes government, managing his public messaging and smoothing over internal quarrels.

Eight years on, hes widely expectedto take over from Abe, who is stepping down for health reasons, with the ruling party picking a new leader on Monday.

Abes time in office provided a period of stability after years of leadership turnover, including his own previous, and brief, premiership in 2006-2007.

The son of farmers, Suga worked his way up through the party machinery, honing his negotiating tactics. Hes played an instrumental role in Abenomics, the premiers marquee economic policy.

As such, Suga is unlikely to substantially change direction. Hes being touted as a continuity candidate who will hew to Abes policies.

On some issues he may push less hard. Abe comes from a family of politicians, including his paternal grandfather and father. His maternal grandfather was prime minister. His hopes of rewriting Japans pacifist constitution were deeply personal. For Suga less so.

But he would still have to manage relationships with the U.S., China, Russia and South Korea. On foreign policy hes largely untested. There are tensions with Beijing and Seoul, especially over Japans wartime past. Suga would need to engage with whoever wins the U.S. election, including on trade.

And its unclear if, at 71, hes seen as a bridging premier, or someone with longevity. With the economy struggling under the pandemic, and structural problems with an aging society and dwindling labor force, Japan can ill-afford a return to leadership uncertainty.

Abegestures atSuga during a news conference in Tokyo on May 4.

Photographer: Eugene Hoshiko/AP

Click herefor Bloombergs most compelling political images from the past week. Tell us how were doing or what were missing atbalancepower@bloomberg.net.

China pitch, 2.0 | President Donald Trump is reviving his 2016 campaign playbook on attacking China, but running as the incumbent means defending a record of limited success in rewriting the economic relationship with Beijing. As Jenny Leonard reports, much of what the Trump team has laid out sounds like campaign promises made four years ago.

Campaign 2020

There are 53 days until the election. Heres the latest on the race for control of the White House and Congress.

Trump and his Democratic rival, Joe Biden, will signal today that their paths to the White House run through Pennsylvania, as both commemorate the anniversary of the Sept. 11 attacks near the town of Shanksville, where one of the hijacked planes crashed in 2001.

Other developments:

Sign up to receive daily election updates as a direct mobile notification on Twitter. Simply click on this link and like the tweet.

Talks fray | The British government rebuffed a European Union request to scrap a plan to re-write their divorce accord after the bloc gave a three-week ultimatum to do so and threatened legal action. The dispute risks jeopardizing efforts to secure a trade deal by Dec. 31 if theres no agreement by then it will trigger tariffs and snarl commerce with extra paperwork at the border.

High stakes | India and China pledged to de-escalate tensions along their disputed Himalayan border after their foreign ministers met yesterdayfor the first time since May, when the stand-off began. The nations have been increasing troop strength along the 3,488-kilometer Line of Actual Control for months and this week the first shots were fired since 1975 an indication multiple rounds of talks have done little to lower the temperature.

Election strategy | With opposition leader Alexey Navalny hit by a near-fatal poisoning, President Vladimir Putin faces a key test of support in Russian regional elections starting today. The three-day ballot, a prelude to 2021 parliamentary elections, is also a showcase for a smart voting campaign promoted by Navalny before he fell ill. It encourages voters in individual areas to back the politician most likely to defeat the ruling United Russia partys candidate.

Corruption probe | Lawmakers in Peru will vote today on whether to start impeachment proceedings against President Martin Vizcarra after the release of tapes of him discussing a minor graft case. Prosecutors are investigating allegations that a singer used contacts in the presidential palace to obtain contracts worth about $50,000, despite lacking experience.

Less than a week after Serbia agreed to move its embassy in Israel to Jerusalem by July as part of a deal with Kosovo brokered by Trump, the Balkan nations president has cast doubts on the plan.

French President Emmanuel Macron is meeting his government today to plan how to curb a surge in coronavirus infections almost 10,000 new cases yesterday without harming a fragile economic rebound.

Pop quiz, readers (no cheating!). Which Disney live-action remake is under pressure for filming in a sensitive region? Send your answer to balancepower@bloomberg.net.

And finally ... The newest Covid-19 vaccine candidate to start human testing is the first where volunteers wont get a painful injection. Instead, theyll receive a spray through the nose. The Chinese-made vaccine joins about 35 other candidates currently in human testing, as the global race to be first with an effective weapon against the deadly pathogen intensifies. Some scientists hope a vaccine that gets sprayed through the nose may have a better chance of stopping the spread of the virus through respiratory tracts.

A woman receives an H1N1 flu nasal spray vaccination in December 2009 in San Francisco.

Photographer: Justin Sullivan/Getty Images North America

With assistance by Karl Maier, Kathleen Hunter, Anthony Halpin, and Isabel Reynolds

Original post:
Patience to Pay Off in Japan for a Loyal Aide - Bloomberg