Why the Gulf monarchies have survived – The Conversation CA

When the Arab Spring protests erupted in 2010, many political pundits predicted the uprisings would ripple through the entire region and ultimately reach the oil-rich Gulf states, sweeping away monarchies.

But ultimately, the Gulf monarchies of Kuwait, Oman, Qatar, Saudi Arabia, the United Arab Emirates and to a lesser extent, Bahrain were the least affected by the Arab Spring. These six Gulf monarchies were more successful in weathering the political storm than their republican neighbours, which in some cases were plunged into civil wars with a heavy humanitarian and economic toll.

I spent a good deal of my life in the region and during the uncertain times of the Arab Spring, so curious colleagues ask me how the Gulf monarchies continue to hold on. In response, I draw not on my memories but on my political training. And I believe there are lessons to learn from the durability of these regimes that could enhance global efforts to understand the region and build sustainable peace in the Middle East.

I generally scoff at the argument that Gulf monarchies have only managed to navigate the tricky waters of the regions geopolitics and avoided a mass exodus of their citizens because of their oil wealth. This popular wisdom holds that petrodollars allow the Gulf monarchies to coax people into submission, and thats why they endure.

Missing from this assessment is acknowledgement that the Gulf monarchies arent the only countries in the broader region with ample hydrocarbon riches. Yet petrodollars in the broader region that often benefited citizens of those countries didnt prevent public anger or major challenges to authority.

Brief comparisons between the Gulf monarchies and other oil-producing countries in the region reveal other common ground besides oil, such as culture and religion. Yet their respective trajectories since the 1950s Gulf monarchies modernized quickly, while other oil-exporting countries (for example Iraq, Libya, Algeria and Iran) have undergone political crises, coups and even regime change. Thats only added to the sense that Gulf monarchies and other oil-producing countries in the region are heading in different directions.

So oil alone doesnt explain the longevity of the Gulf monarchies. Other factors help explain their success.

First and foremost is whether people in the Gulf region see monarchy as a legitimate form of government. In Western political thought, elections represent one of the key benchmarks for judging the legitimacy of government. This is the foundation of participatory democracy.

By this token, only leaders from presidential republics pass muster in terms of Western legitimacy. After all, these countries hold regular presidential elections.

But are those elections themselves legitimate?

In 2011, at the height of the Arab Spring, Elliott Abrams, deputy national security adviser to former U.S. President George W. Bush, wrote that Arab monarchies are more legitimate than the false republics. This assessment raises two critical issues.

The first is the reliability of elections in the Gulf. Presidential elections in Middle Eastern republics have often been fraudulent. It would make a mockery of democracy to consider these elections proof of legitimacy.

The second concerns the compatibility between society and its political institutions. This is one of the pillars of stability in any society. Hereditary monarchies like the ones in the Gulf arent a novelty for the native cultures of the region. These monarchies therefore derive legitimacy from the fit between their royal institutions and the cultural norms of their people. This is a traditional form of political legitimacy.

With their emphasis on tradition, hierarchy, loyalties and social alliances, monarchies are accepted by many of the cultures of the Arabian Peninsula. The Gulf monarchies were borne out of their own socio-cultural heritages, and this gives them more legitimacy.

This legitimacy however sets certain limits on executive authority and places demands on the monarchs, who are expected to be arbiters between competing interests benevolent stabilizers, so to speak. In fact, problems have arisen when monarchs fail to project this image or perform this role.

An example is Bahrains mass protests in 2011, when many citizens felt their king showed little commitment to the principles of compromise and moderation that had largely characterized his predecessors reign.

The arbiter status gives the monarchs respect and authority, which enables them to rule at distance.

This has helped them maintain power with less reliance on force than their non-monarchy neighbours, which base their claims for legitimacy on political ideology like nationalism and independence. More often than not, these ideologies dont resonate with people. This poses a major challenge to their ability to maintain power, so the republics rely more on force and security to maintain power.

This best expresses itself in Syria, where the Al-Assad regime has ruled for decades through a network of overlapping security agencies to enforce questionable legitimacy.

Thats why the regional republics were hit harder by the Arab Spring. Popular uprisings there were fuelled by greater discontent.

This has spared the Gulf monarchies from frequent legitimacy crises and allowed them to divert resources to other aspects of governance, like building state capacity. This refers to the ability of governments to employ administrative and technical processes, rather than force, to address societal challenges and create stability.

State capacity is bound with a countrys investment in education and human capital, which in turn create a capacity for informed decision-making. This is evident in the volume of publications by Gulf universities. Despite the relative youth of universities in Gulf monarchy states most of them were founded in the mid-1970s they outperform their counterparts in Arab republics in terms of quantity of publications.

The future success of the Gulf monarchies probably hinges on further investment in education.

Doing so will enhance the quantity and quality of intellectual activity and produce citizens who can share power, steer economies in response to societal and technological challenges and guarantee long-term stability.

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Why the Gulf monarchies have survived - The Conversation CA

Heightened Worry About Risk And Growing Interest In Retirement Income, According To New Study By American Century Investments – PRNewswire

The eighth annual study, comprised of responses from 1,508 full-time workers between the ages of 25 65 grouped by the categories of Baby Boomers, Generation X and Millenials, examined their wishes and worries about retirement savings. The survey compared and contrasted insights of both plan sponsors and participants, according to American Century Investments Vice President, Value Add Diane Gallagher.

"The results of this year's study show high expectations around the role of employers and both the priority and value placed on employer-sponsored retirement benefits," Gallagher said. "These findings can help retirement plan decision-makers consider participants' points of view in building effective solutions."

Key study findings include:

Risk

Participants are concerned about multiple types of risks including market risk, longevity risk, inflation and interest rate risk, growth risk, and human error.

Half of Boomers surveyed are most concerned about market risk. However, concern over market risk and growth risk has risen significantly from last year. "Perhaps the timing of the survey had some influence here as we were researching in March, at the advent of the COVID-19 pandemic and in the midst of high volatility," Gallagher said.

Four in 10 express concern about running out of money in retirement, a significant decline from last year and similar to 2018. Participants with $500,000 or more in assets are more likely than those with less than $100,000 in assets to be concerned about the inability to afford health expenses, loss of structure, missing co-workers and being bored.

The share most concerned about longevity risk is down significantly from last year (28% vs. 42% in 2019). Market risk overtook longevity risk as participants' greater concern in this year's survey. "Again, this may be related to the first signs of the pandemic, but we cannot say with certainty," Gallagher said.

Men are more likely to select growth risk as the risk that concerns them most, while women are more apt to chose longevity risk.

Retirement Income

Some eight out of 10 respondents said they would be more likely to leave money in their plan if their employer offered an investment option specifically to help retirees draw income during retirement. Participants report rollover IRA as the most common distribution option today. "Clearly, there is a strong preference for leaving assets in the plan at retirement and taking withdrawals from the plan to fund retirement," Gallagher said. "Investment solutions offering a retirement income stream provide plan participants with peace of mind after leaving an employer. This interest certainly has implications for plan sponsors and providers to offer solutions to make that a reality for participants."

ESG

One in eight participants say they work for a company that offers ESG investments, a significant increase from last year's findings. Also, men are more likely to be extremely or very interested in having an ESG option as part of their retirement savings plan. Further, participants with an income of at least $100,000 are more likely to be extremely interested in ESG investments. "The role of plan fiduciaries is very clear: To act in the best interests of plan participants when selecting and evaluating investments. As ESG is increasingly applied in investments, it will be important for plans to understand ESG and implications for plan investments."

Expectations

Nearly all participants continue to say retirement savings is an important goal; one-third call it the biggest or only goal, with men and those with assets of $100k or more tending to say saving for retirement is their biggest goal.

Furthermore, worries about financial matters abound with half of all participants worrying a "great deal" about saving enough for retirement, according to the research. Gen Xers, generally, have more worries. Men are more likely than women to say that worrying about saving enough for retirement, health/living a healthy enough lifestyle, saving enough for their children's college education, investing properly for their goals and supporting an adult child keeps them up most nights.

Paying off debts, such as monthly and long-term credit card debt and student loans, are a higher priority for participants in 2020 than in 2019, and paying off longer-term credit card debt and student loans are more of a priority for those with less than $100k in assets.

"We found that half of those surveyed are worried or concerned about saving enough for retirement, including one in eight saying it keeps them up at night," Gallagher said. "About half are also concerned about having enough savings for the next unexpected expense, especially Millennials and Gen X."

Most Millennials select housing as a major priority, while many Gen Xers and Boomers choose retirement savings as a major priority. Boomers are more likely than Millennials and Gen Xers to rank retirement savings number one. Gen Xers have a high priority on housing and saving for their children's education.

Participants believe they could have saved more money earlier in their careers. Most report not saving enough in the first five years they worked. Nine in 10 participants think that if they could talk to their early career selves, it would be important to advise themselves to save more, but only seven out of 10 believe their earlier selves would listen. Boomers do not feel it as likely as others that their younger selves would have listened. "There are two things at play here" Gallagher said. "First, participants acknowledge the 'power of compounding' and know had they started earlier, their accounts would have had more time to grow. Second, the past seven years of our research have shown this sense of remorse about saving and their personal spending habits. Participants recognize that, had they started saving earlier, they would have just continued on that path and not fallen out of the habit."

Overall, three in 10 expect their standard of living in retirement to be better than it is now.

Advice

This year's study found that three in four participants would find it attractive if their employer were to offer them holistic financial advice, a significant increase from last year. Additionally, participants making at least $100,000 per year were more likely to find this offer attractive. Similar shares of participants currently use personal research, financial advisors, and family for advice on investing,with Boomers most likely to use a professional advisor. "Given the premium participants place on the role of employers, it's not surprising that particpants would look to employers to offer a source of financial advice. Participants seem a little overwhelmed at all the advice options available to them, so getting that advice through an employer-provided source is valuable."

Participants are also split on their feelings towards paying for professional advice. Four in 10 believe paying for an advisor is worth the cost. Another four in 10 would rather pay less for software or an online program. The rest, two in 10, will never pay for professional advice.

Additionally, women are more inclined to prefer an online advice service over an advisor, based on cost, and men are more likely to believe paying for an advisor is worth the cost.

Despite these splits, three in four participants still believe a professional advisor will play a role in helping them prepare for retirement going forward. Two-thirds believe the same about software, a significant increase from last year.

Uber 401(k) Plans

Participants with an income of at least $100k are more inclined to strongly believe their retirement savings plan at work is one of the most important benefits their employer offers.

Some seven in 10 respondents support an automatic increase of a 6 percent employer match (Am I interpreting this correctly?), and two out of three believe their employer should automatically enroll employees into their plan at a set percent and increase it automatically each year.

Also important for employers to know is that 60% feel more positively about a company that offers automatic enrollment, automatic increase and target-date investments, according to Gallagher. "Nearly eight in 10 participants would like their employer to offer at least some encouragement to save more. When asked what role they would like employers to play, eight in ten want at least 'a slight nudge.' This has been consistent over the years of the study," she said.However, older generations are more likely than Millennials to say, "leave me alone."

Further, four in 10 participants think employers should structure retirement plans to be completely automatic for employees. Men and those with an income of at least $100,000 are more likely to prefer the automatic option.

Finally, amajority prefer a match on their retirement contribution over a salary increase. Millennials and Gen Xers are more likely to prefer salary increases than Boomers. Men prefer the 6% increase in salary more so than women. "This has been consistent over the years of our survey: Participants value a company match over a salary increase if given a choice. That may have implications for employers as they look at compensation and employee benefits."

American Century's Defined Contribution Investment Only (DCIO) assets under management totaled $42.4 billion, and target-date assets under management totaled more than $23 billion as of June 30, 2020.

Survey Methodology

The plan participant survey was conducted between March 10 and 31, 2020. Survey included 1,508 full-time workers between 25 and 65 saving through their employer's retirement plan. The data were weighted to reflect the makeup of key demographics (gender, income, and education) among all American private sector participants between 25 and 65.

Data collection and analysis were completed by Mathew Greenwald and Associates of Washington, D.C.

American Century Investments is a leading global asset manager focused on delivering investment results and building long-term client relationships while supporting research that can improve human health and save lives. Founded in 1958, American Century Investments' 1,400 employees serve financial professionals, institutions, corporations and individual investors from offices in New York; London; Frankfurt; Hong Kong; Sydney; Mountain View, Calif.; and Kansas City, Mo. Jonathan S. Thomas is president and chief executive officer, and Victor Zhang serves as chief investment officer. Delivering investment results to clients enables American Century Investments to distribute over 40 percent of its dividends to the Stowers Institute for Medical Research, a 500-person, non-profit basic biomedical research organization. The Institute owns more than 40 percent of American Century Investments and has received dividend payments of $1.6 billion since 2000. For more information about American Century Investments, visit http://www.americancentury.com.

A strategy or emphasis on environmental, social and governance factors ("ESG") may limit the investment opportunities available to a portfolio. Therefore, the portfolio may underperform or perform differently than other portfolios that do not have an ESG investment focus. A portfolio's ESG investment focus may also result in the portfolio investing in securities or industry sectors that perform differently or maintain a different risk profile than the market generally or compared to underlying holdings that are not screened for ESG standards.

2020 American Century Proprietary Holdings, Inc. All rights reserved.

American Century Investment Services, Inc., Distributor

Contact:Laura Kouri(816) 516-7729

SOURCE American Century Investments

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Heightened Worry About Risk And Growing Interest In Retirement Income, According To New Study By American Century Investments - PRNewswire

Longevity And Anti-Senescence Therapy Market Projected size Witness a Double-Digit CAGR during COVID-19 2023 – Chelanpress

Theglobal longevity and anti-senescence therapies marketshould grow from $329.8 million in 2018 to $644.4 million by 2023 with a compound annual growth rate (CAGR) of 14.3% during 2018-2023.

Report Scope:

The scope of this report is broad and covers various therapies currently under trials in the global longevity and anti-senescence therapy market. The market estimation has been performed with consideration for revenue generation in the forecast years 2018-2023 after the expected availability of products in the market by 2023. The global longevity and anti-senescence therapy market has been segmented by the following therapies: Senolytic drug therapy, Gene therapy, Immunotherapy and Other therapies which includes stem cell-based therapies, etc.

Revenue forecasts from 2028 to 2023 are given for each therapy and application, with estimated values derived from the expected revenue generation in the first year of launch.

Request for Report Sample:https://www.trendsmarketresearch.com/report/sample/11698

The report also includes a discussion of the major players performing research or the potential players across each regional longevity and anti-senescence therapy market. Further, it explains the major drivers and regional dynamics of the global longevity and anti-senescence therapy market and current trends within the industry.

The report concludes with a special focus on the vendor landscape and includes detailed profiles of the major vendors and potential entrants in the global longevity and anti-senescence therapy market.

Report Includes:

71 data tables and 40 additional tables An overview of the global longevity and anti-senescence therapy market Analyses of global market trends, with data from 2017 and 2018, and projections of compound annual growth rates (CAGRs) through 2023

Country specific data and analysis for the United States, Canada, Japan, China, India, U.K., France, Germany, Spain, Australia, Middle East and Africa Detailed description of various anti-senescence therapies, such as senolytic drug therapy, gene therapy, immunotherapy and other stem cell therapies, and their influence in slowing down aging or reverse aging proce

Coverage of various therapeutic drugs, devices and technologies and information on compounds used for the development of anti-ageing therapeutics A look at the clinical trials and expected launch of anti-senescence products Detailed profiles of the market leading companies and potential entrants in the global longevity and anti-senescence therapy market, including AgeX Therapeutics, CohBar Inc., PowerVision Inc., T.A. Sciences and Unity Biotechnology

Summary

Global longevity and anti-senescence therapy market deals in the adoption of different therapies and treatment options used to extend human longevity and lifespan. Human longevity is typically used to describe the length of an individuals lifetime and is sometimes used as a synonym for life expectancy in the demography. Anti-senescence is the process by which cells stop dividing irreversibly and enter a stage of permanent growth arrest, eliminating cell death. Anti-senescence therapy is used in the treatment of senescence induced through unrepaired DNA damage or other cellular stresses.

Global longevity and anti-senescence market will witness rapid growth over the forecast period (2018-2023) owing to an increasing emphasis on Stem Cell Research and an increasing demand for cell-based assays in research and development.

An increasing geriatric population across the globe and a rising awareness of antiaging products among generation Y and later generations are the major factors expected to promote the growth of global longevity and anti-senescence market. Factors such as a surging level of disposable income and increasing advancements in anti-senescence technologies are also providing traction to the global longevity and anti-senescence market growth over the forecast period (2018-2023).

According to the National Institutes of Health (NIH), the total geriatric population across the globe in 2016 was over REDACTED. By 2022, the global geriatric population (65 years and above) is anticipated to reach over REDACTED. An increasing geriatric population across the globe will generate huge growth prospectus to the market.

Senolytics, placenta stem cells and blood transfusions are some of the hot technologies picking up pace in the longevity and anti-anti-senescence market. Companies and start-ups across the globe such as Unity Biotechnology, Human Longevity Inc., Calico Life Sciences, Acorda Therapeutics, etc. are working extensively in this field for the extension of human longevity by focusing on study of genomics, microbiome, bioinformatics and stem cell therapies, etc. These factors are poised to drive market growth over the forecast period.

Global longevity and anti-senescence market is projected to rise at a CAGR of REDACTED during the forecast period of 2018 through 2023. In 2023, total revenues are expected to reach REDACTED, registering REDACTED in growth from REDACTED in 2018.

The report provides analysis based on each market segment including therapies and application. The therapies segment is further sub-segmented into Senolytic drug therapy, Gene therapy, Immunotherapy and Others. Senolytic drug therapy held the largest market revenue share of REDACTED in 2017. By 2023, total revenue from senolytic drug therapy is expected to reach REDACTED. Gene therapy segment is estimated to rise at the highest CAGR of REDACTED till 2023. The fastest growth of the gene therapy segment is due to the Large investments in genomics. For Instance; The National Human Genome Research Institute (U.S.) had a budget grant of REDACTED for REDACTED research projects in 2015, thus increasing funding to REDACTED for approximately REDACTED projects in 2016.

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Longevity And Anti-Senescence Therapy Market Projected size Witness a Double-Digit CAGR during COVID-19 2023 - Chelanpress

Evolution of technology, mindsets and more in the time of crisis – Forbes India

After months of lockdown and living with restrictions necessitated by the Covid-19 pandemic, most businesses have been severely impacted. On the other hand, a silver lining has been a shift in businesses processes and practices, providing an opportunity to reinvent how companies are run. To create agile, transparent and resilient organisations requires reimagining of management principles and business models.

To share their insight on this development, Forbes India brought together a diverse panel of business barons to share their learnings and offer perspectives for longevity in enterprises. Moderated by Manu Balachandran, special correspondent, Forbes India, the participants included Atul Jalan, CEO, Manthan; Rono Dutta, CEO, IndiGo; RM Vishakha, MD & CEO, IndiaFirst; Dr. Nandakumar Jairam, chairman & CEO, Columbia Asia Hospitals; Karan Bajwa, CEO, Google Cloud India, and Sanjay Gupta, CEO, Google India.

Vishakha recounted that her organisation was able to seamlessly move everything to work from home, thanks to a robust business continuity plan and access to technology. From investments to the call centres, everything functioned smoothly despite being in remote locations.

A challenge for bringing in new business, she admits, is to be able to replace the human connect. For a business like ours, which entails selling a promise for a 15 to 20-year period, acquiring new clients is dependent on building relationships and instilling trust. We still have to figure out how to inspire trust in potential clients without the human touch, while we are just a face on a video or a call on the phone. This is especially pertinent in an environment where cheating is so rampant.

Offering his perspective, Gupta explained how the pandemic has made him unlearn assumptions that constant travel is a business necessity, and that finding partners, such as international experts, entailed a lot of cooperation and waiting. During the lockdown, not only did he experience that work went on just as well when he couldnt travel, and connecting with international experts and colleagues became much faster and more effective online. I am more humbled at the end of this experience and I realise that many things are possible by simply changing ones mindset, he concluded.

Seconding Gupta, Bajwa observed that there have been some fundamental shifts in business processes. First, the way technology was used has changed. There is a clear opportunity to shift technology from being an enabler of a business to the fore of a business. Second, a shift in the consumption model of technology towards being considered as regular opex rather than large lump sum capex will remove cost barriers for constant usage of relevant technology. All these shifting trends present businesses with a real opportunity to completely reinvent themselves, rather than merely reorient, he said.

Jairams observations highlighted that there such parallels could be drawn for the health care industry as well. The administrative segment is very much like what the others already described - going to office, copious travel on work, etc. These activities revealed themselves as a waste of time and money when technology enabled virtual meetings delivered greater efficient than before, he said, explaining that his organisation has become more comfortable with tele-consultations and remote delivery of medicine. It is efficient, saves time waiting at hospitals and is definitely going to enable a patient and doctor to interact in a different way.

Dutta of IndiGo voiced the possibility that many businesses and leaders might go back to embracing conventional ways once they can do so. After 9/11, people stopped traveling and video conferencing was all the rage. But they had to revert to physical meetings that demanded travel, because sometimes the human touch and relationship building that was crucial to building businesses was missing, he said. Even within an organisation, networking and knowing people across different divisions is a great asset. We are social animals, so as long as human beings do business and take decisions, relationships are key; it could simply mean getting together and having a drink in the evening. Thats what makes things work. He also agreed that the pandemic has altered the way he approached his work: I used to be a big believer in long-term planning and that has been turned on its head. Right now, we don't know which segments will open and what mandates will follow. So, we have to just plan for the short term and take a lot of course corrections as we go, he said.

Jalan of Manthan believed that the pandemic has just speedened up the adoption of trends and technolgoies that had already made their way into business consciousness. Video conferencing, work from home, telemedicine, none of these are new trends. But this pandemic has put all those trends on steroids. There were talks about universal basic income, data monetisation, data privacy, how to regulate the role of social media, etc. I think this crisis has brought all these and other issues to the fore.

He pointed out that the best of human ingenuity comes forth during times of challenge and crisis and constraint, and technology would facilitate this resourcefulness. At a personal level, he added, it has been a reminder that change is the only constant and that we have to quickly adapt to change to flow with the times.

The discussion proceeded with the participants sharing their experiences on how mindsets of customers, as well as management and employees of the company had changed. Bajwa explained how the changing mindsets during the crisis presented Google with the opportunity to approach its clients with the intent of serving and not selling. We engaged with customers and enabled them to achieve the first level of being able to work from home, getting connected, using collaboration platforms, etc, he said, adding that technology companies will now need to start providing technology to customers in a manner that is not elitist, but democratised.

Gupta summed up the observations made by his colleague, by stating that the greatest transformation among consumers and business owners and boards was the openness to change and do it fast. He pointed out two distinct themes that had emerged in business thinking - concerns around conserve cash and ideating toward transformation of the business. The silver lining to the crisis is that it has forced people and companies to introspect on what is really important to them, he said. As a result, in the post Covid-19 world, human needs will become sharper and technology will help deliver experiences safely.

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Evolution of technology, mindsets and more in the time of crisis - Forbes India

How close are we to a coronavirus vaccine? All you need to know – THE WEEK

On Saturday, India's Serum Institute of India (SII), which has partnered with British pharma giant AstraZeneca for manufacturing the Oxford vaccine candidate for COVID-19, sought permission from the Drugs Controller General of India (DCGI) for conducting Phase II and III human clinical trials of the potential vaccine, highly-placed sources said on Saturday.

As reported by news agency PTI, the Pune-based drug firm submitted its application to the DCGI on Friday seeking permission for conducting the trials of the vaccine candidate 'Covishield'. According to the application, it would conduct an observer-blind, randomised controlled study to determine the safety and immunogenicity of 'Covishield' in healthy Indian adults. The firm said that an around 1,600 participants of more than 18 years would be enrolled in the study.

After reports in the medical journalThe Lancetclaimed the initial trial results showed that the vaccine was safe and prompted protective immune response, the firm plans to start phase II and III human trials in India in August.

At the same time, the Phase I human clinical trial of India's first indigenously-developed vaccine against novel coronavirus, COVAXIN, began at the AIIMS with the first dose of the injection given to a man, who is in his 30s. Already, over 3,500 volunteers have registered themselves for the trial, of whom the screening of at least 22 people is underway, said Dr Sanjay Rai, Professor at the Centre for Community Medicine at AIIMS and the principal investigator of the study.

The global race for vaccines is well and truly on. Last week, Michael Ryan, the head of emergencies at the World Health Organisation, had hailed "good news" from two COVID-19 vaccine candidates in early human trials, but warned that there was a long way to go. "We now need to move into larger-scale real-world trials. But it is good to see more data and more products moving into this very important phase of vaccine discovery," Ryan told reporters at a news conference. Ryan's comments came after scientists at Oxford University,in a paper published in the medical journalThe Lancet, said their experimental vaccine had been shown to trigger a protective immune response in hundreds of people who got the shot. Also, in the journal, Chinese researchers from CanSino Biologics published a study on their experimental vaccine, which uses a similar technique as the Oxford team, that also reported an immune response.

Vaccine testing is a four-stage processpre-clinical testing on animals; phase I clinical testing on a small group of people to determine its safety and to learn more about the immune response it provokes; phase II trials, or expanded safety trials, where dosage and frequency will be tested across wider cross-sections of the population; phase III large-scale tests where the vaccine is administered to thousands of people to confirm its efficacy. Phase I and phase II are the early trials, which will then be followed by a rigorous, intensive Phase III clinical testing, where the longevity of the vaccine response (whether the vaccine will last for long periods of time) will be analysed.

At the same time, a vaccine candidate under development by Pfizer Inc and Germany's BioNTech showed promise in a small, early study.

What do all these studies mean?

Let us take them one by one.

InThe Lancet, Oxford University scientists said their vaccine candidate, prepared in partnership with the pharma giant AstraZeneca, appeared safe in the early trial phases, inducing a strong immune response within the body.Doses of the vaccine were given to 1,077 healthy adults aged between 18 and 55 in five UK hospitals in April and May as part of the phase I clinical trial and results. The results show they induced strong antibody and T-cell responses for up to 56 days after they were given. T-cells are immune responses by the body against the foreign virus, and are crucial for maintaining protection against the virus for longer periods of time.

"In addition, the strongest immune responses were produced in 10 participants who received two doses of the vaccine, indicating that this might be a good strategy for vaccination," said Andrew Pollard, chief investigator of the Oxford vaccine trial.

At the same time, a vaccine candidate under development by China's CanSino Biologics Inc and the country's military research unit, showed similar safe immune response in most of the 508 healthy volunteers.

Both the vaccine candidates (CanSino and Oxford-AstraZeneca) are adenoviral vector vaccines; that means they are prepared from a weakened, non-replicating version of a common cold virus that carries the coronavirus spike proteins into the human body, helping the immune system identify and build antibodies against the virus.

Both the studies reported adverse events such as fatigue, headache, and local tenderness, but found those to be tolerable and mostly ameliorated by paracetamol.

At the same time,Pfizer and BioNTech also released an early phase non-peer reviewed study which claimed thatvirus-neutralising antibodies were induced in 60 adults who were given two doses, a result in-line with a previous early-stage US trial.These preliminary data are encouraging in that the vaccine is able to produce neutralising antibody responses in humans, and that it does so at relatively low dose levels,Ugur Sahin, MD and CEO of BioNTech, said in a statement. The Pfizer-BioNTech candidate is an RNA vaccine. Here, no attenuated viruses are injected. Rather, a genetic code is introduced, which induces the human cells to create the foreign protein, alerting the immune system, and help the body recognise the entry of the virus in all its forms. The RNA vaccines are easier to make, but they are a new and unproven technology.

These studies come on the back of early phase results released byAmerican biotech giant Moderna, which said their RNA vaccine prompted neutralising antibody activities in healthy adults, though it led to minor side effects in many patients.

Russia, meanwhile, has made progress with a vaccine developed by the Gamaleya Institute in Moscowfinanced and backed by the Russian defence ministry. State-run news agency TASS had reported that the vaccine had completed human trials though it has only cleared Phase-I trials so far and is currently undergoing Phase-II trials. Russias deputy defence minister has said that this vaccine is ready, noting that of the two groups of volunteers who were administered the vaccine, all had built up immunity

Russian Health Minister Mikhail Murashko on Saturday said that the vaccine developed by the Gamaleya Institute, as well as a vaccine developed by the Vektor State Research Center of Virology and Biotechnology which was recently approved for clinical trials, were neck and neck.

Russia plans to begin mass production of the Gamaleya vaccine in August, with medical workers to start receiving the vaccine that very month. The vaccine will be widely used in parallel with Phase III trials, Murashko said.

Lastly, an RNA vaccine being developed by the Imperial College, London, showed promise when tested on mice, hwihc developed highly-=specific COVID-19 antibodies that were able to neutralise the virus. This vaccine has since been approved for human trials across England with trials on more than 200 people.

What are the challenges next?

Longevity of the vaccine effects will undoubtedly be the biggest challenge, which will be addressed in the phase III trials. The vaccine developed by Oxford University has shown some positive signs of protection in the preliminary results of the early trial. It is being claimed that it will be more effective than others because it will develop antibodies and "natural killer cells" [T-cells] against SARS-COV2. But the biggest challenge would be the longevity of the [neutralising] antibodies,Sunit K. Singh, professor and head, molecular biology, Institute of Medical Sciences, Banaras Hindu Universitytold THE WEEK.

In SARS-CoV-2, antibodies are known to fade between three-six months, as reported by various studies, he said. So what would be the fate of protection induced by a vaccine once the antibody response vanishes or is reduced? A virus of this kind will certainly need an attack from both sidesthe antibodies and T-cells, he added.

How are Indian pharma companies placed?

At least seven Indian pharma companies are working to develop a vaccine against coronavirus as they join global efforts to find a preventive to check the spread of the deadly virus that has already infected more than 14 million globally. Bharat Biotech, Serum Institute, Zydus Cadila, Panacea Biotec, Indian Immunologicals, Mynvax and Biological E are among the domestic pharma firms working on the coronavirus vaccines in India.

Bharat Biotech has received approval to conduct phase I and II clinical trial for its vaccine candidate COVAXIN, that has been developed and manufactured in the company's facility in Hyderabad. Last week, it started the human clinical trials.

Pharma majorZydus Cadila has said that it is looking to complete clinical trials of its COVID-19 vaccine candidate ZyCoV-D in seven months. The company had last week started clinical trials of its COVID-19 vaccine candidate with the first human dosing. Depending on the study outcomes, and if the data is encouraging, and the vaccine is found to be effective during the trials, it could take a total of seven months for the trials to be completed and for the vaccine to be launched, Zydus Cadila Chairman Pankaj R. Patel said in a statement.

Panacea Biotec in June said that it was setting up a joint venture firm in Ireland with US-based Refana Inc to develop a vaccine for COVID-19. The company, in partnership with Refana, aims to manufacture over 500 million doses of COVID-19 candidate vaccine, with over 40 million doses expected to be available for delivery early next year, Panacea Biotec had said.

Indian Immunologicals, a subsidiary of National Dairy Development Board (NDDB), has inked an agreement with Australia's Griffith University to develop a vaccine for coronavirus.

Others like Mynvax and Biological E are also working to develop vaccines for COVID-19.

-Inputs from Namita Kohli

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How close are we to a coronavirus vaccine? All you need to know - THE WEEK

Ask Hackaday: Why Did GitHub Ship All Our Software Off To The Arctic? – Hackaday

If youve logged onto GitHub recently and youre an active user, you might have noticed a new badge on your profile: Arctic Code Vault Contributor. Sounds pretty awesome right? But whose code got archived in this vault, how is it being stored, and whats the point?

On February 2nd, GitHub took a snapshot of every public repository that met one of the following criteria:

Then they traveled to Svalbard, found a decommissioned coal mine, and archived the code in deep storage underground but not before they made a very cinematic video about it.

For the combination of longevity, price and density, GitHub chose film storage, provided by piql.

Theres nothing too remarkable about the storage medium: the tarball of each repository is encoded on standard silver halide film as a 2d barcode, which is distributed across frames of 8.8 million pixels each (roughly 4K). Whilst officially rated for 500, the film should last at least 1000 years.

You might imagine that all of GitHubs public repositories would take up a lot of space when stored on film, but the data turns out to only be 21TB when compressed this means the whole archive fits comfortably in a shipping container.

Each reel starts with slides containing an un-encoded human readable text guide in multiple languages, explaining to future humanity how the archive works. If you have five minutes, reading the guide and how GitHub explains the archive to whoever discovers it is good fun. Its interesting to see the range of future knowledge the guide caters to it starts by explaining in very basic terms what computers and software are, despite the fact that de-compression software would be required to use any of the archive. To bridge this gap, they are also providing a Tech Tree, a comprehensive guide to modern software, compilation, encoding, compression etc. Interestingly, whilst the introductory guide is open source, the Tech Tree does not appear to be.

But the question bigger than how GitHub did it is why did they do it?

The mission of the GitHub Archive Program is to preserve open source software for future generations.

GitHub talks about two reasons for preserving software like this: historical curiosity and disaster. Lets talk about historical curiosity first.

There is an argument that preserving software is essential to preserving our cultural heritage. This is an easily bought argument, as even if youre in the camp that believes theres nothing artistic about a bunch of ones and zeros, it cant be denied that software is a platform and medium for an incredibly diverse amount of modern culture.

GitHub also cites past examples of important technical information being lost to history, such as the search for the blueprints of the Saturn V, or the discovery of the Roman mortar which built the Pantheon. But data storage, backup, and networks have evolved significantly since Saturn Vs blueprints were produced. Today people frequently quip, once its on the internet, its there forever. What do you reckon? Do you think the argument that software (or rather, the subset of software which lives in public GitHub repos) could be easily lost in 2020+ is valid?

Whatever your opinion, simply preserving open source software on long timescales is already being done by many other organisations. And it doesnt require an arctic bunker. For that we have to consider GitHubs second motive: a large scale disaster.

We cant predict what apocalyptic disasters the future may bring thats sort of the point. But if humanity gets into a fix, would a code vault be useful?

Firstly, lets get something straight: in order for us to need to use a code archive buried deep in Svalbard, something needs to have gone really, really, wrong. Wrong enough that things like softwareheritage.org, Wayback Machine, and countless other conventional backups arent working. So this would be a disaster that has wiped out the majority of our digital infrastructure, including worldwide redundancy backups and networks, requiring us to rebuild things from the ground up.

This begs the question: if we were to rebuild our digital world, would we make a carbon copy of what already exists, or would we rebuild from scratch? There are two sides to this coin: could we rebuild our existing systems, and would we want to rebuild our existing systems.

Tackling the former first: modern software is built upon many, many layers of abstraction. In a post-apocalyptic world, would we even be able to use much of the software with our infrastructure/lower-level services wiped out? To take a random, perhaps tenuous example, say we had to rebuild our networks, DNS, ISPs, etc. from scratch. Inevitably behavior would be different, nodes and information missing, and so software built on layers above this might be unstable or insecure. To take more concrete examples, this problem is greatest where open-source software relies on closed-source infrastructure AWS, 3rd party APIs, and even low-level chip designs that might not have survived the disaster. Could we reimplement existing software stably on top of re-hashed solutions?

The latter point would we want to rebuild our software as it is now is more subjective. I have no doubt every Hackaday reader has one or two things they might change about, well, almost everything but cant due to existing infrastructure and legacy systems. Would the opportunity to rebuild modern systems be able to win out over the time cost of doing so?

Finally, you may have noticed that software is evolving rather quickly. Being a web developer today who is familiar with all the major technologies in use looks pretty different from the same role 5 years ago. So does archiving a static snapshot of code make sense given how quickly it would be out of date? Some would argue that throwing around numbers like 500 to 1000 years is pretty meaningless for reuse if the software landscape has completely changed within 50. If an apocalypse were to occur today, would we want to rebuild our world using code from the 80s?

Even if we werent to directly reuse the archived code to rebuild our world, there are still plenty of reasons it might be handy when doing so, such as referring to the logic implemented within it, or the architecture, data structures and so on. But these are just my thoughts, and I want to hear yours.

The thought that there is a vault in the Arctic directly containing code you wrote is undeniably fun to think about. Whats more, your code will now almost certainly outlive you! But do you, dear Hackaday reader, think this project is a fun exercise in sci-fi, or does it hold real value to humanity?

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Ask Hackaday: Why Did GitHub Ship All Our Software Off To The Arctic? - Hackaday

Sunday Reflection with Fr Robin Gibbons – 26 July 2020 | ICN – Independent Catholic News

The Dream of Solomon, by Luca Giordano

Seventeenth Sunday in Ordinary Time

How often do you think of yourself in terms of a sister or brother of Jesus, or see our relationship with one another in terms of the family of God to which we belong through the gift of our baptism and confirmation? I am sure you do from time to time, but does it matter, is it important?

The second reading from the letter to the Romans hints at this in the phrase about Christ being the firstborn of many brothers and sisters, who have a purpose and mission in life, one which will lead them to be glorified, but in the process means bearing witness to Christ and his teaching.

All this can seem very far removed from ordinary, daily life with all its demands, but we are foolish if we think it does not mean anything for us. Today more than ever, the community that follows Christ is being called to a determined witness in an arena where our faith is being challenged on so many fronts, the old sign posts of truth, ethics, respect have shifted, Christianity itself is in danger of polarisation if we are not careful of what we say and do. Opposition to faith is strong in many areas of the world; the privileged influence of our faith in societal life is no longer as secure as once it was.

It is significant that in our first reading from the book of Kings, Solomon's response to God's appearance in his dream promising to fulfil anything he asks, is not for power, wealth, influence or even longevity, it is for something far more important: 'Give your servant, therefore, a listening heart to judge your people and to distinguish between good and evil. For who is able to give judgment for this vast people of yours?' (I Kgs 3:9) This is exactly what we need to be praying for each and every day, a listening heart. Like Solomon we can respond to God by asking for the same gift because it is tied up with the ministry of proclaiming the Kingdom and the saving gift of Christ, we have aright as children of the One god, sisters and brothers of Jesus to ask in his name these much needed gifts of discernment and guidance. Around us evil and good are mixed together, sometimes evil masquerades as good and it takes great foresight to see through the disguises it adopts. It has always been axiomatic that sin comes in attractive packages but with no spiritual health warnings. It is our task to help guide people into choosing the constructive options for good, not destruction and hurt.

Look at the TV, read online or in journals and newspapers the 'sordid', disreputable and dishonourable activities done by people of power who are able to convince others that what they do is apparently for our good. It takes a strong person to swim against the tide of opinion and I am afraid we in the Church are as much to blame as anybody, there are some very odd ideas floating about, many of them need good strong theological critique to help bring our minds back to the presence of Christ, to hear the word of God and to commit ourselves to active ministry and mission for our poor battered Earth, a world that encompasses not only human life but all creatures and life on earth. We are being challenged to stand up and bear witness to the truth and joy of Christ's promise to us. That also is the hidden message of the parables of the Kingdom Jesus teaches, how good and bad alike are growing together, but it is at the end that the bad are separated out. An interesting thought about the need for our discernment and a listening heart! But, what do we say the Kingdom of heaven is like in our age, how would you describe it, how best can we discern it for ourselves and others?

Lectio

'The Kingdom of God'.

Francis Thompson (1859 - 1907)

O world invisible, we view thee,O world intangible, we touch thee,O world unknowable, we know thee,Inapprehensible, we clutch thee!

Does the fish soar to find the ocean,The eagle plunge to find the air-That we ask of the stars in motionIf they have rumour of thee there?

Not where the wheeling systems darken,And our benumbed conceiving soars!-The drift of pinions, would we hearken,Beats at our own clay-shuttered doors.

The angels keep their ancient places-Turn but a stone and start a wing!'Tis ye, 'tis your estrangd faces,That miss the many-splendored thing.

But (when so sad thou canst not sadder)Cry-and upon thy so sore lossShall shine the traffic of Jacob's ladderPitched betwixt Heaven and Charing Cross.

Yea, in the night, my Soul, my daughter,Cry-clinging to Heaven by the hems;And lo, Christ walking on the water,Not of Genesareth, but Thames!

Fr Robin is an Eastern Rite Catholic Chaplain for Melkites in the UK. He is also an Ecumenical Canon of Christ Church Cathedral, Oxford. You can follow him on Twitter: @RobinGibbons2

Tags: Sunday Reflection with Fr Robin Gibbons, 26 July 2020

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Sunday Reflection with Fr Robin Gibbons - 26 July 2020 | ICN - Independent Catholic News

Opinion | Is Adam Wainwright a Hall of Famer? – KSDK.com

Will Wainwright wear a red jacket AND be invited to Cooperstown, or just one? I examined the veteran Cardinal after another vintage performance.

ST. LOUIS Adam Wainwright is going to own a red suit one day.

That is already cemented in stone, an announcement simply waiting for the pitcher to hang up his cleats. Perhaps Wainwright could be the first member to keep pitching even though he sits in a Hall of Fame. He'll get there as a Cardinal when it's all said and done.

But what about Cooperstown? Cardinal Nation asked this recently with Jim Edmonds and Scott Rolen, a pair of great Cardinals who came up short due to overall career statistics or unfortunate injury. Edmonds had a couple very good bursts of MLB action. He put together a six years stretch that is MVP-like. Rolen suffered a shoulder injury with the Cardinals that affected him the rest of his career. Is it the same case with Wainwright?

For Wainwright, the injury bug will most likely keep him out of MLB Hall of Fame contention. He'll get on a ballot with his two rings, and near 180 career wins with a moderate amount of dominance-but I wouldn't expect an introduction at Cooperstown.

And it's okay. The list of great pitchers who aren't in the Hall runs for miles. A particularly interesting case is Dwight "Doc" Gooden. He spent the majority of his career with the New York Mets, gathering 194 wins and a Cy Young award along with many other trophy accumulations. But his 16-year career is not in the Hall of Fame. A very good pitcher who simply didn't dominate for long enough.

Wainwright was robbed of nearly two seasons by the Tommy John surgery in 2011 and Achilles tendon rupture in 2015. If he gets 15-20 wins in those seasons, he easily over 200 wins at the moment. That win mark would seem to the opening of the conversation for a Hall of Fame stop. 300 wins is a sure thing, but 200 gets the ball rolling for pitchers.

This isn't a shot at Wainwright's career. Talk about a storied trip that should spurn stories and legends for decades to come. Coming to St. Louis in a big trade with the Atlanta Braves as a starter, but hitting it big with the team initially as a closer.

When Jason Isringhausen's hip worsened and his save percentage dropped in 2006, it was Wainwright flying in to the rescue, and throwing the final pitch of the playoffs that year. If anyone forgets to mention Wainwright freezing Carlos Beltran during the NLCS that fall, please rewrite their list for them in a hurry.

2007 found him as a full time starter, and it took two years for Wainwright to become an ace. He won 19 or more games in four different seasons. In three different seasons, Wainwright gave the Cardinals more than 227 innings. He was a boss for five seasons, with the worst one coming right after his arm surgery in 2011.

In four seasons, Wainwright was a top three finalist for the Cy Young award, and he gathered top 20 MVP votes in three seasons. He also owns a 2.81 ERA in 27 career playoff games, 14 of which he started. When the team needed a lift, Wainwright was there.

The Achilles incident really cost Wainwright. The Tommy John surgery was unfortunate and stopped a good run, but he had come all the back from that before the injury in Milwaukee that cracked his career in half. Since that injury, Wainwright has never finished with an ERA below 4.00.

But the good thing is, these days offer a place for pitcher who can keep the number right around 4.00. Right when you thought it was getting real close to the end in 2018, Wainwright made another comeback, the second of his career. After signing a one year contract packed with incentives, Wainwright offered the team 31 starts, 172 innings, and a 4.19 ERA last season. He was also one of the best arms in the playoffs, including 11 strikeouts and just one walk against the eventual World Series champion, Washington Nationals.

Wainwright keeps finding new ways to produce results. He kicked off 2020's weird yet fun season with a win on Saturday afternoon, shutting down the Pittsburgh Pirates for six innings. The only run he allowed, along with five strikeouts and just three hits, came off a generous call from the home plate umpire. Just like he mastered last year, Wainwright is using his location skills and brain to out-think hitters.

Think about it. He's always been a bulldog on the mound, raising the tenacity and no quit limits to the highest levels possible, pushing himself into his 15th year as a Major League pitcher. Wainwright doesn't have the overpowering fastball these days, and his curveball can be deadly but also suddenly become hit and miss in its existence. He's found new ways to get outs in order to extend his career.

So, why talk about the Hall of Fame all of a sudden? There's a variety of ways to answer that question. The first is that, like it or not, Wainwright is near the end. It will be a sad day in this town when he no longer climbs a pitching mound and plays catch with Yadier Molina. Wainwright turns 39 in August, so he can only go on for so long.

Another way would be to say I saw a tweet and it made me think for a few minutes. The lovely and esteemed baseball writer Chelsea Ladd put something out that got people talking. Here it is:

Now, let me acquit Ms. Ladd by saying she added in a follow-up tweet that she never meant to say he belonged in Cooperstown. Like me, Ladd thinks he is a sure-fire Cardinals Hall of Famer. He will get a red jacket after he retires.

And that shouldn't be a cheap alternative to the Hall. Think about it. Gooden was inducted into the Mets Hall of Fame in 2010. Like Wainwright, he had a few seasons where he was lights out, but after 6-7 seasons in New York, Gooden lost his magic and simply tried to get outs for the rest of his career.

For my money, the Hall of Fame is the top of the mountain for athletes. It's a recognition unlike any other. But if you asked Wainwright if he'd hand over his two World Series rings for a spot in Cooperstown, I'd like to think the answer would be quick and painless. Wainwright found his own brand of legend in St. Louis, a longevity most pitchers don't get to experience.

Let's face it. It's becoming a certainty that Wainwright is going to finish his career in St. Louis. I doubt if he wanted to pitch next year to some degree and it wasn't a sure thing for it to continue in St. Louis, he would step down and call it. That's the class in Wainwright, which along with his charity work in town, speaks to the first-class human that the pitcher is and has been for a decade and a half.

Wainwright is a Hall of Fame person, and a very good pitcher. He'll retire with honors and accolades, becoming a fine coach and St. Louis area legend.

Look at that. 2020 has given us many poor and distasteful things, but it's giving me a glimpse into the future for some wild reason. I am taking advantage of the very temporary superpower to talk about a guy who will start and finish his career in one town, pitching for one team.

For Adam Wainwright and the Cardinals, the future is still looking bright. Sounds Hall of Fame enough to me.

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Opinion | Is Adam Wainwright a Hall of Famer? - KSDK.com

The US, Australia and Canada lead, but no G20 country is fully prepared for the needs of ageing populations, according to new research from the…

HONG KONG, CHINA - Media OutReach - 22 July 2020 - Morepeople are living into old age than ever before. In 2018 The World HealthOrganization predicted that by 2020 there would be more people aged over 60years than there are children under 5 years. This prediction is on track to becorrect,and numbers in the older cohort continue to rise. This hascreated challenges in providing health and social services for burgeoning olderpopulations and governments across the globe have been slow to react.Priorities are now shifting from solely addressing the health of older people,to how societies can maximise this opportunity and provide effective, inclusiveenvironments in which to age.

This report from The Economist Intelligence Unit describesfindings from the "Scaling Healthy ageing, Inclusiveenvironments and Financial security Today" (SHIFT) Index", a benchmarking analysis around ageingsocieties, supported by Amgen. The SHIFTIndex benchmarks against a set of national-level leading practices increating an enabling environment supportive of longevity and healthy ageing forsocieties in the 19 countries comprising the Group of Twenty (G20). The SHIFT Index captures the multifactorialvariables that impact ageing across three domains: adaptive health and socialcare systems; accessible economic opportunity; and inclusive social structuresand institutions.

The research found that no G20 country isfully prepared to support healthy, financially secure, socially-connected olderpeople. The US, Australia, Canada and South Korea ranked highest in our indexwith scores in the 70s out of 100 (see table below). Broadly, those countrieswith a higher proportion of people aged over 50--including the three highest ranking countries plus South Korea,Germany, France and Japan--are implementing moreleading practices to enable inclusive environments. Wealthy countries may findit easier to respond, but wealth is not a prerequisite for providing supportiveenvironments. The best scoring health systems tend to be high-income countries,but upper-middle income Brazil, and lower-middle income Indonesia are alsomaking strides to improve health systems.

As a whole, the G20 countries perform bestin providing adaptive healthcare systems and worst in providing inclusivesocial structures and institutions, indicating that countries still have workto do to shift the focus towards building more welcoming societies for olderadults as they age. Countries also have room to improve in providing moreaccessible economic opportunities to older workers.

Despite clear progress made, governmentshave more work to do to make sure their health systems are adaptive to theneeds of older adults as they age, while also fostering inclusion and ensuringindividual economic security. A keybarrier to addressing this is lack of robust age-disaggregated data collectionby governments in areas such as dedicated health professionals, the extent ofisolation and loneliness as well as mental health.

The SHIFTIndex reveals several priority areas that may form the basis of policyresponses to develop more accessible and inclusive societies for older people:

Jesse Quigley Jones, managing editor at TheEconomist Intelligence Unit and editor of the report, said, "The challengesthat ageing populations present for economies and health systems have long-beenunderstood, yet provision of inclusive, supportive environments for olderpeople has not been a high-profile policy priority. Although wealth has emergedas a theme in the Index as a contributing factor towards healthy ageingindicators, it is not necessarily a prerequisite for providing supportiveenvironments. Lower-income nations can take low-cost measures that improveageing societies, such as enacting inclusive work environment policies andfostering inclusive and enabling social environments.

With older people particularly vulnerableto the health and societal impact of the covid-19 pandemic, it is moreimportant than ever for older people to lead healthy, independent lives for aslong as possible and avoid the need for institutional care. While our data werecollected pre-pandemic, the priorities identified in the report are now throwninto sharper light and may serve as a wakeup call for governments across theglobe for providing adaptable, accessible and inclusive environments in whichpopulations can age."

Forthe whitepaper, infographic and index workbook, please visitageingshift.economist.com

Shifting demographics: a global study oninclusive ageing is a report by The EconomistIntelligence Unit, supported by Amgen. It considers policy efforts to addressactive and inclusive ageing in 19 countries based on a first-of-its-kind indexthat benchmarks each country's performance across accessible and affordablehealthcare, social connectivity among older adults, and finance security practicesand policies.

The "Scaling Healthy ageing, Inclusiveenvironments and Financial security Today" (SHIFT) Index and the relatedresearch programme whose findings form the basis for this report were informedby extensive research and guided by an international panel of experts fromacross academia, government, non-governmental organizations (NGOs) andinternational financial institutions.

The following 19 countries (comprisingthe G20 and excluding the EU) are included in this analysis: Argentina, Australia,Brazil, Canada, China, France, Germany, India, Indonesia, Italy, Japan, Mexico,Russia, Saudi Arabia, South Africa, South Korea, Turkey, the UK and the US.These were selected to broadly represent the world: covering roughly 65% of thepopulation and 75% of global GDP.

The EconomistIntelligence Unit is the world leader in global business intelligence. It isthe business-to-business arm of The Economist Group, which publishes TheEconomist newspaper. The Economist Intelligence Unit helps executives makebetter decisions by providing timely, reliable and impartial analysis onworldwide market trends and business strategies.

More informationcan be found at http://www.eiu.com or http://www.twitter.com/theeiu

Amgen is committedto unlocking the potential of biology for patients suffering from seriousillnesses, by discovering, developing, manufacturing and delivering innovativehuman therapeutics. This approach begins by using tools like advanced humangenetics to unravel the complexities of disease and understand the fundamentalsof human biology.

Amgen focuses onareas of high unmet medical need, and leverages its expertise to strive forsolutions that improve health outcomes and dramatically improve people's lives.A biotechnology pioneer since 1980, Amgen has grown to be one of the world'sleading independent biotechnology companies, has reached millions of patientsaround the world, and is developing a pipeline of medicines with breakawaypotential.

For moreinformation, visit http://www.amgen.com or http://www.twitter.com/amgen.

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The US, Australia and Canada lead, but no G20 country is fully prepared for the needs of ageing populations, according to new research from the...

The Greatest Disruptor Of The 21st Century Makes Health Our Most Precious Asset – Forbes

Bill Gates famously warned in 2015 that the next big threat to humanity was a pandemic that we are not ready for.But did he predict that the Covid-19 virus would take top spot as the greatest disruptor this century- ahead of technology and the aging population?

Living with the pandemic has become the new normal, and made the world realize that health is our greatest asset and cornerstone of prosperity.

But who could have imagined, even six months ago, that governments around the world would inject over $9 trillion to save the global economy?These bailouts are ushering in a new era of state intervention in our lives and the public is on side.

Respondents to the Edelman Trust Barometer conducted in April want government out front in all areas of the pandemic response: to provide economic relief (86%), to get the country back to normal (79%), to contain Covid-19 (73%), and to inform the public (72%). The barometer also shows the pandemic has cast a spotlight on systemic inequity- with 67% believing that those with less education, less money and fewer resources are bearing a disproportionate burden of the suffering.

There is no doubt that the fracture lines of society have been horribly exposed, with those in the poorest health and living in deprived communities hardest hit. For some countries, the immediate threat has receded at least for now- whereas for others, like in the U.S.A. and South America, worse is yet to come.Most experts agree that we will be living with the pandemic for some time, even if a vaccine becomes available later this year.

While governments and healthcare systems wrestle with the immediate crisis, businesses have had to act quickly too.

Almost overnight, major companies shifted most of their employees home to work remotely, and patients turned to chatbots, apps and video calls rather than travel to the clinic to see their doctors. The pandemic has shown how quickly we can make radical changes to our lifestyles, abandoning habits and practices long seen as essential- and leaving empty trains and desolate city centers in the process. These shifts may not be temporary either- indeed may become permanent reminders of dramatic behavioral and cultural shifts underway.

Rather perversely, many positives are unfolding that are powerful and compelling.For one thing, leaders have a once-in-a-lifetime opportunity to reshape how societies can provide healthier, better, greener, and more equitable outcomes for all, an opportunity that the World Economic Forum has hailed as the Great Reset.The cornerstone of this Reset is a new stakeholder capitalism; indeed, in May 2020, aFortune surveyfound that roughly half of chief executive officers believe the crisis will accelerate their move towards this more inclusive version of capitalism.

And it will be the innovative, ethical companies responding nimbly and creatively in addressing the urgent societal challenges facing us who will benefit most- as proponents argue that social returns will bring commercial returns too.Companies like Sainsburys prioritizing deliveries to the most vulnerable and Co-Op usingits community wellbeing index to triage support during the crisis; LMVH, the company behind Dior and Louis Vuitton, that converted their plants to make hand sanitizer for hospitals at no cost; and BrewDog, the UK brewer, that launched its own sanitizer for the NHS, with Anheuser-Busch,Pernod-Ricard, Bacardi, Tito and smaller distilleries doing the same in the U.S.A.In Asia, financial market operatorHKEX organized an emergency relief donation of HK$10 million to local communities and NGOs.

Beyond the immediate crisis, there is still a lot for business to do. Despite the many great examples of purpose-driven businesses doing great things, half of the people recently surveyed by Edelman believe business is doing poorly, mediocre or completely failing at putting people before profits. Fortunately, the changes we have already seen in response to Covid-19 prove that a reset of our economic and social foundations is possible, and is our best chance to instigate stakeholder capitalism.

The time is now to make this a permanent fixture of the new normal.

In February, the U.K.s All-Party Parliamentary Group (APPG) for Longevity published The Health of The Nation: A Strategy for Healthier Longer Livesto deliver 5 extra years of healthy life expectancywhile minimizing heath inequalities -a government ambition enshrined in the current government manifesto.Published just before the impact of the pandemic took old, its recommendations are no less important, and indeed have become more pressing and resonant.

The continued work of the APPG in seeking ways to improve the health of the nation and reduce health inequalities is so important to us all now more than ever," says Yvonne Sonsino, Global Co-Leader, Next Gen at Mercer.

One of the recommendations, a Business Coalition for a Healthier Nation, is now in the process of being set up, with leaders from insurance, banking and other sectors, and with the support of central government.The Coalition recognizes that shaping the recovery and charting a new course for growth ahead will require greater collaboration between businesses, academia, government institutions and citizens themselves.

It places preventative health firmly at the center to build up health and economic resilience. Indeed, arguably the even bigger crisis looming is the chronic disease epidemic- delays in cancer diagnosis andbacklogs of cases have all increased with people fearful of seeing doctors and going to hospitals, only adding to the significant burden that existed before the pandemic.The recent OpenSafely study showed that people with obesity, diabetes, coronary heart disease and hypertension were much more likely to die from Covid-19, all mostly preventable diseases linked to social inequalities too.

A recent McKinsey report estimates that the cost of ill health was about 15% of global real GDP in 2017, and that the Covid-19 pandemic and its repercussions will reduce global GDP by 3 to 8 % in 2020, concluding: Long-term prevention and health promotion, which encompasses more than 70% of the benefits we identified, cannot simply be left to healthcare providers or healthcare systems. It is quite literally everybodys business.

In response, the Business Coalition is proposing, amongst other things, to develop a risk management framework for health and corresponding index to measure business contributions to health.It recognizes the link between human health and planetary heath too. As Colin Matthews, Chairman of EDF Energy, said: Therell be no healthy economy without a healthy population and a healthy planet.

Indeed, health is where the climate change agenda was 10 years ago.Businesses involved in the Coalition argue we should be guiding investment and innovation decisions by Environmental, Social and Governance (ESG) mandates like we do for climate change, applying them to healthy life expectancy and societal health; institutional investors should be thinking about the stranded asset risk of things that cause health risks, and businesses should report on health risks like they are doing increasingly on climate issues. Crucially, Coalition leaders say we need to prioritize capital for large-scale, long-term, sustainable investment in preventative health.

Andy Briggs, CEO of Phoenix Group, Co-Chair of the U.K. Longevity Council, and founding member of the Coalition, says: We need to show how to make sustainability absolutely core in all businesses.

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The Greatest Disruptor Of The 21st Century Makes Health Our Most Precious Asset - Forbes

Global Anti-Senescence Therapy Market 2020 Business Strategies, Product Sales and Growth Rate, Assessment to 2025 – Cole of Duty

COVID-19 Updates We will be covering the overall impact of COVID -19 on the market value, market share & growth of the market and how the major players in the particular market are adapting these changes.

MarketResearchBazaar has added latest research report on Global Anti-Senescence Therapy Market, this report helps to analyze top manufacturers, regions, revenue, price, and also covers Industry sales channel, distributors, traders, dealers, Research Findings and Conclusion, appendix and data source.

The global Anti-Senescence Therapy market was valued at $XX million in 2019, and MAResearch analysts predict the global market size will reach $XX million by the end of 2026, growing at a CAGR of XX% between 2019 and 2026.

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In this report, the study analysis was given on a worldwide scale, for instance, present and traditional Anti-Senescence Therapygrowth analysis, competitive analysis, and also the growth prospects of the central regions. The report gives an exhaustive investigation of this market at country &, regional levels, and provides an analysis of the industry trends in each of the sub-segments, from sales, revenue and consumption. A quantitative and qualitative analysis of the main players in related regions is introduced, from the perspective of sales, revenue and price.

According to Research, the global Anti-Senescence Therapy market was valued at USD xxx million in 2019, and it is expected to reach a value of USD xxx million by 2026, at a CAGR of xx% over the forecast period 2021-2026. Correspondingly, the forecast analysis of Anti-Senescence Therapy industry comprises of Asia, North America, South America, Middle East and Africa, Europe, with the sales and revenue data in each of the sub-segments.

At the upcoming section, this report discusses industrial policy, economic environment, in addition to the fabrication processes and cost structures of the industry. And this report encompasses the fundamental dynamics of the market which include drivers, opportunities, and challenges faced by the industry. Additionally, this report showed a keen market study of the main consumers, raw material manufacturers and distributors, etc.

Geographically, this report is segmented into several key Regions, with production, consumption, revenue (M USD), market share and growth rate of Anti-Senescence Therapy in these regions, from 2014 to 2026 (forecast), covering

Asia-Pacific (China, Japan, Korea, India and Southeast Asia)

North America (United States, Canada and Mexico)

Europe (Germany, France, UK, Russia and Italy)

South America (Brazil, Argentina, Columbia)

Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

Global Anti-Senescence Therapy market competition by top manufacturers, with production, price, revenue (value) and market share for each manufacturer, the top players including

Unity Biotechnology

Siwa Therapeutics

Calico LLC

AgeX Therapeutics

Numeric Biotech

Human Longevity

Cleara Biotech

OisinBiotechnologies

Recursion Pharmaceuticals

Sierra Sciences

Proteostasis Therapeutics

Senolytic Therapeutics

Allergan

On the basis of product, this report displays the production, revenue, price, market share and growth rate of each type, primarily split into

Gene Therapy

Immunotherapy

Others

On the basis on the end users/applications, this report focuses on the status and outlook for major applications/end users, consumption (sales), market share and growth rate of Anti-Senescence Therapy for each application, including

Cardiovascular Diseases

Neural Degenerative Diseases

Ophthalmology Disorders

Others

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Major Point of TOC:

Chapter One: Anti-Senescence Therapy Market Overview

Chapter Two: Anti-Senescence Therapy Market Segment Analysis by Player

Chapter Three: Anti-Senescence Therapy Market Segment Analysis by Type

Chapter Four: Anti-Senescence Therapy Market Segment Analysis by Application

Chapter Five: Anti-Senescence Therapy Market Segment Analysis by Sales Channel

Chapter Six: Anti-Senescence Therapy Market Segment Analysis by Region

Chapter Seven: Profile of Leading Anti-Senescence Therapy Players

Chapter Eight: Upstream and Downstream Analysis of Anti-Senescence Therapy

Chapter Nine: Development Trend of Anti-Senescence Therapy (2020-2029)

Chapter Ten: Appendix

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Global Anti-Senescence Therapy Market 2020 Business Strategies, Product Sales and Growth Rate, Assessment to 2025 - Cole of Duty

Genomics Market Provides in-depth analysis of the Genomics Industry, with current trends and future estimations to elucidate the investment pockets By…

The report is a comprehensive research study of the Global Genomics Market inclusive of the latest trends, growth factors, developments, opportunities, and competitive landscape. The research study includes an in-depth analysis of the market using advanced research methodologies such as SWOT analysis and Porters Five Forces analysis. The report is formulated from data gathered from primary and secondary research examined and validated by industry experts. The report provides an overview of market leaders, segmented by type, application, region, and technological advancements.

Furthermore, the report provides a comprehensive analysis of the impact of the COVID-19 crisis on the market. It offers a detailed insight into the impact of COVID-19 on the industry at a regional level and industry level. The report also covers the developments and regulatory policies related to COVID-19. It further analyzes the current and future impact of COVID-19 on the global market and provides insights into the situation post-COVID-19.

Get a sample copy of the Genomics market report @ https://www.reportsanddata.com/sample-enquiry-form/2975

The report provides assistance to the clients by providing insightful data about limitations and opportunities to enable a decision-making process. The report provides an in-depth insight into the growth factors, recent technological developments, and comprehensive profiling of the key market players. The report titled Global Genomics Market Report Forecast to 2027 provides essential information about the techniques of the key players in the industry, their technological advancements, and assists readers in making profitable business decisions.

The key players studied in the report are 23andMe, Oxford Nanopore Technologies, Precise.ly, 54Gene, Guardant Health, Allogene Therapeutics, Oxford Nanopore Technologies, Pacific Biosciences, CardioDx, Helix, Human Longevity, Foundation Medicine, Freenome, and Veritas Genetics.

The report further segments the market based on product type and end-use applications. It provides insightful data and strategic recommendations in order to gain a better understanding of the global scenario.

Product types in the market:

key applicationsin the market:

Request a discount on the report @ https://www.reportsanddata.com/discount-enquiry-form/2975

Market Drivers and Constraints:

The global Genomics market research report provides a brief overview inclusive of the competitive landscape and key developments, policies, manufacturing costs, and processes. The report also provides an analysis of import/export, production and consumption ratio, supply and demand, cost, price, estimated revenue, and gross margins.

The report further discusses in detail the driving factors influencing the growth of the market currently and in the coming years. It also sheds light on restraints that are expected to hamper the growth of the industry.

Following significant market factors are discussed in the report:

To know more about the report @ https://www.reportsanddata.com/report-detail/genomics-market

The report studies the main players of the market along with their strategies, business expansion plans, and competitive prospects. The report also studies micro and macro-economic factors, government policies, consumer dynamics, and manufacturing aspects. The report provides a detailed COVID-19 impact analysis.

David is an Experience Business writer who regularly contributes to the blog, He specializes in manufacturing news

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Genomics Market Provides in-depth analysis of the Genomics Industry, with current trends and future estimations to elucidate the investment pockets By...

Why John Lewis Kept Telling the Story of Civil Rights, Even Though It Hurt – TIME

John Lewis served in Congress since 1987, representing Georgia in the House of Representatives. But his constituents were far from all the longtime legislator, who died on Friday at age 80, represented.

Lewis was a witness to, participant in and survivor of some of the most pivotal moments of the American civil rights movement: he gave a speech at the 1963 March on Washington; he marched across the Edmund Pettus Bridge in Selma, Ala., in 1965; he took part in more recent acts of resistance. In a movement in which so many great lights were extinguished early, his longevity left him to serve as a de facto spokesman for what he saw.

But its not by chance that Lewis name is tied so closely to the nations still-visceral memories of those moments. Throughout his life, the Congressman spoke often about his purposeful quest to tell and retell the story of what he had been through, so that nobody could forget. He turned his experiences into bestselling books and share-worthy speeches and even a catchphrase and he did so with intention.

In 2017, Lewis spoke to TIME for the magazines 10 Questions feature. In this previously unpublished excerpt from the conversation, Lewis explained why he kept telling his story, even though it wasnt easy for him:

Youve talked about the importance of telling the story [of the civil rights movement] over and over again, and how it affects the people who hear it. But how does telling that story again and again affect you?

Yes, when I tell the story, and I tell it over and over again, even for hundreds and thousands of students, to little children and adults who come to the office or when Im out on the road speaking, it affects me and sometimes it brings me to tears. But I think its important to tell it. Maybe it will help educate or inspire other people so they too can do something, they too can make a contribution.

I went up to Rochester, N.Y., back in October, with a colleague of mine, Louise Slaughter, who represents Rochester. [Slaughter died in March of 2018.] And I went to a church that Frederick Douglass had attended, an African American Methodist church, and I went to a house called the Motherhouse. Two of the nuns that took care of us at the hospital in Selma when we were beaten on March 7, 1965, they retired there. These two nuns are feeble, up in age, but they recognized me and they called me John and I called them sisters. There were many other nuns sitting around and they started crying and I cried with them and hugged them, and they showed me this stained glass that was taken from the chapel of the hospital in Selma, which is now closed, and theyd brought it to Rochester. And we stood there and did a song and a hymn.

Its uplifting and its powerful to me to tell the story and to respond to people asking questions. It makes us all stronger and more determined.

Civil Rights leaders, including future Congressman John Lewis (third left) and Gloria Richardson (third right), chair of the Cambridge Non-Violent Action Committee, link hands as they march in protest of a scheduled speech by the pro-segregationist Alabama governor, George Wallace in Cambridge, Md., in May 1964.

Francis MillerThe LIFE Picture Collection via Getty Images

Ive heard that one of the catalysts that inspired you to run for office was the run of terrible things that happened at the end of the 1960s, the assassinations of Robert Kennedy and Martin Luther King Jr. Whats the key to responding to terrible things by taking action rather than just collapsing?

You have to pull up on the best in the human spirit. You just say Im not going to be down. You have what I call an executive session with yourself. You could say, Listen self, listen John Lewis, youre just not going to get lost in a sea of despair. Youre not going to be down. Youre going to get up.

The assassinations of Dr. Martin Luther King Jr. and Robert Kennedy was the saddest time in my life. I admired both Martin Luther King Jr. and Robert Kennedy. I admired those two men. Martin Luther King Jr. had taught me how to stand up, to speak up and speak out, and how to get involved. When I first met him, he called me the Boy from Troy, and up until the time of his death, he still referred to me as the Boy from Troy, because I grew up outside of Troy, Alabama. And I met Robert Kennedy for the first time in 1963, when I was 23 years old, before the March on Washington. And he was so inspiring, so uplifting. In my Washington office, I have a picture with him when he was Attorney General, from a campaign poster from 1968. These two young leaders, I thought, represented the very best of America. And when Dr. King was assassinated, I was with Bobby Kennedy when we heard. And as a matter of fact, it was Bobby Kennedy that announced at this campaign rally at Indianapolis, Indiana, to the crowd. As I was working on this campaign, trying to get people to come out to the rally, he said, we have some bad news tonight, Martin Luther King Jr. was assassinated in Memphis, Tennessee. I heard that hed been shot but we didnt know his condition.

And I really felt when the two of them died that something died in America. Something died in all of us. And sometimes we never recover from situations like these. I became convinced in myself that I had to do something, I had to pick up where Dr. King left off and Bobby Kennedy left off.

One of the civil rights-era experiences that Lewis often recounted, as he told what he had been through, was the experience of hearing Martin Luther King Jr. speak on the radio when Lewis was a teenager. Lewis felt, he would say, that King was speaking directly to him, telling him to get involved and that the spirit of history was moving through him, too. The spirit of history told him that the moment was right to stand up, and that the time had come to take his place in the story of the world.

Now, as America remembers a civil rights leader who protected and advanced that legacy in the decades after Kings assassination, it seems safe to say that the spirit was right.

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Write to Lily Rothman at lily.rothman@time.com.

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Why John Lewis Kept Telling the Story of Civil Rights, Even Though It Hurt - TIME

Coronavirus May Have Come From Bats; Could They Also Hold Clues to Treatments? – HealthDay News

THURSDAY, July 16, 2020 (HealthDay News) -- Bats have been blamed as a possible source of the new coronavirus pandemic ravaging the globe. But they might also point to possible ways out of it.

Scientists say the winged mammals' immune systems may offer clues on how to fight the new coronavirus and other dangerous viruses in humans.

"Humans have two possible strategies if we want to prevent inflammation, live longer and avoid the deadly effects of diseases like COVID-19," explained study lead author Vera Gorbunova, a professor of biology at the University of Rochester in New York. "One would be to not be exposed to any viruses, but that's not practical. The second would be to regulate our immune system more like a bat."

Many deadly viruses that affect people are believed to have originated in bats, including rabies, Ebola and SARS-CoV-2, the strain that causes COVID-19. But bats have evolved a secret weapon: They're better able to tolerate viruses than humans and other mammals.

"We've been interested in longevity and disease resistance in bats for a while, but we didn't have the time to sit and think about it," Gorbunova said in a university news release.

"Being in quarantine gave us time to discuss this, and we realized there may be a very strong connection between bats' resistance to infectious diseases and their longevity. We also realized that bats can provide clues to human therapies used to fight diseases," she explained.

Typically, a species' lifespan is associated with its body size. The smaller a species, the shorter its lifespan. But many bat species have lifespans of 30 to 40 years, which is impressive for their size, the authors noted in a review article published recently in Cell Metabolism.

Bats' longevity and tolerance to viruses may be due to their ability to control inflammation, which is involved in both aging and disease. Viruses, including COVID-19, can trigger inflammation.

With COVID-19, this inflammatory response goes "haywire," Gorbunova said. In fact, in many cases it is the inflammatory response that kills the patient, more so than the virus itself.

"The human immune system works like that: Once we get infected, our body sounds an alarm and we develop a fever and inflammation. The goal is to kill the virus and fight infection, but it can also be a detrimental response as our bodies overreact to the threat," Gorbunova said.

In contrast, bats' immune systems control viruses without mounting a strong inflammatory response.

There are several possible reasons why bats evolved to fight viruses and live long lives. Flight may be one of them, the researchers noted.

Bats are the only mammals that can fly, which required them to adapt to rapid increases in body temperature, sudden surges in metabolism and molecular damage. These adaptations may also assist in disease resistance, the study authors suggested.

Another factor is that many species of bats live in large, dense colonies, and hang close together on cave ceilings or in trees. Those conditions are ideal for transmitting viruses and other pathogens.

According to Andrei Seluanov, a biology professor at the University of Rochester, "Bats are constantly exposed to viruses. They are always flying out and bringing back something new to the cave or nest, and they transfer the virus because they live in such close proximity to each other."

This means that bats' immune systems are continuously adapting to deal with new viruses. Studying bats' immune systems could lead to new ways to fight aging and diseases in humans, the researchers said.

More information

The U.S. Centers for Disease Control and Prevention has more on COVID-19.

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Coronavirus May Have Come From Bats; Could They Also Hold Clues to Treatments? - HealthDay News

Covid-19 vaccine will reach usable stage after 2020: Expert – Northeast Now

Amid speculations over Covid-19 vaccines, a top official from the Indian Medical Association (IMA) has reportedly claimed that a vaccine would reach usable stage only after 2020.

A usable vaccine to cure COVID-19 and bringing the same to good use would go beyond 2020, a news agency quoted an Dr V K Monga, IMA Board of Hospitals Chairman as saying.

He said that developing a vaccine for viral infections is a longer process as firstly, these infections have shorter immunity and secondly, viruses mutate faster, so this makes developers clueless as to which mutation is there in which part of the country.

Dr Monga further said for developing a vaccine there are multiple stages and steps.

Developing a vaccine is not a political decision, it involves a lot of steps and procedures, he said.

First, we isolate the virus then you develop an antidote to that, followed by animal testing and then on human volunteers. Secondly, you see the efficacy, toxicity and then its longevity as to how long it sustains, Monga said.

He said since, the viral infections have shorter immunity; a vaccine with a longer effect is to be seen, secondly, we have to see that it has no side effect and thirdly, viruses mutate faster and hence, it has to be seen that the vaccine is effective on most of the mutants as we dont know which mutated virus is present in which part of the country.

Speaking about the rise in the recovery rate, Dr Monga said that in this particular disease, approximately 80 per cent of the people are recovering on their own.

These patients will automatically recover. Home isolation is a good thing, he said.

Monga said people using masks and adhering to social distancing norms is also increasing recovery.

However, he clarified that plasma therapy, which is being seen as the only solution to COVID-19 in place of the absence of the vaccine, cant minimise the need of a vaccine.

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Covid-19 vaccine will reach usable stage after 2020: Expert - Northeast Now

How genetic studies will become the holy grail to find cancer biomarkers in future – Express Healthcare

Dr Villoo Morawala-Patell, Founder, Avesthagenand her team has been researching on genetic basis of disease risk associated with longevity and the endogamy prevalent within various communities. Theirpurpose is to deliver population-specific qualified biomarker targets to achieve the holy grail of genomics predictive, preventive, and personalised medicines. In an interview withRaelene Kambli, Dr Patell reveals more on their research and its application in the development and validation of cancer biomarker. She also delved into explaining theneed for a cross-disciplinary integration of scientific and clinical expertise for research especially in the field of cancer

What according to you is the most promising area of your current research?

The most promising area of our current work in terms of innovation is the significant and prolific outcomes from the Avestagenome Project for cancers, neurodegenerative conditions, and rare diseases. Our recent work on the genomics of the Zoroastrian-Parsis converges, ancient history, human migration, endogamous population genetics, social behaviour and customs that express in genetic signatures of wellness and health.

Specifically, we present a population genetics study wherein we assembled the first,de novoZoroastrian-Parsi Mitochondrial Reference Genome from one individual and the first Zoroastrian-Parsi Mitochondrial Consensus Genome derived from the assembly of 100 complete mitochondrial genomes of the dwindling, endogamous, non-smoking Zoroastrian-Parsi community of India. Phylogenetic analysis of the 100 Parsi mitochondrial genome sequences, showed a largely Persian origin for the Parsi community of India.Disease association mapping showed that the majority of the mitochondrial variants to be linked longevity and its associated conditions revealing the genetic basis for many of the heritable diseases in the community like cancer, neurodegenerative diseases like Parkinsons, Alzheimers and many rare genetic conditions.Our study is a first in tackling the genetic basis of disease risk associated with longevity and the endogamy prevalent within the community. The outcome of this study has an impact on all populations

So, your paper suggests that Zoroastrian-Parsi genes may help scientists characterise biomarkers predictive of diseases caused by tobacco use, such as lung, head and neck, and oesophagus cancers. Can you elaborate on the same?

We found 420 mitochondrial variants in our analysis of the 100 Zoroastrian-Parsi mitochondrial genomes. The detailed analysis brought to light the absence in the Zoroastrian-Parsi samples variants in mitochondrial genes like ND5, ND6 and tRNA that are shown to be associated with lung cancer and non-small cell lung cancer in other non-Parsi populations. Many of these reported genes have been associated with smoking-induced lung cancer and other smoking-induced cancers. Our study thus serves as a biological validation ofa well-known cultural phenomenon, reflecting the practice of abstinence from smoking in Zoroastrian-Parsis whose origins date back a millennium.

How helpful is this information for your research and what does it imply?

Our study is unique and provides a road map for understanding the genetic factors that underlie ageing and longevity associated diseases. A vast majority of the 420 mitochondrial variants are associated with longevity and conditions like Parkinsons disease, Alzheimers disease as well as breast, colon, prostate, ovarian cancer, infertility disorders like asthenozoospermia and rare neuronal diseases associated with mitochondrial dysfunction. Indeed, epidemiological studies of the community do show a preponderance of these diseases and a strong bias for the inheritance of these genetic disease variants owing to the practice of endogamy within the community. Our current study will complement our research goals as we accelerate our whole-genome analysis of the Parsi community to identify from the control population, alongside other comparative population subjects. The purpose is to deliver population-specific qualified biomarker targets to achieve the holy grail of genomics predictive, preventive, and personalised medicines.

What are the key findings of this study?

Our insights from the assembly of the archetypical Zoroastrian-Parsi mitochondrial genome extend from human migration to the genetic basis of disease prevalence. Our phylogenetic analysis showsalargely Persian origin for the Parsi community and revealed the presence of seven major haplogroups and 25 sub-haplogroups in our study group.We believethe strict endogamy practised by the Zoroastrian-Parsi community, has meant that their maternally inherited mitochondrial genome has remained largely unchanged from that of their ancestors in Old Persia. We also see the prevalence of genetic variants, specifically 217 unique variants linked to longevity and 41 longevity associated conditions like cancers, neurodegenerative disease, and rare diseases. We did not find any mitochondrial variants previously reported for lung cancer in our study and found an extremely low frequency of mutational signatures linked to tobacco carcinogens, reflective of the strong disapproval of smoking in the Zoroastrian religion. Another exciting outcome of our study is the discovery of 12 unique mitochondrial gene variants distributed across 27 subjects that have not been reported in public databases that index mitochondrial variants discovered thus far in other studies. We are currently in the process of investigating their function in the context of diseases.

So, you mean the gene expression picked from this study can be implemented to tailor adjuvant therapy among common cancers?

Mutations in mitochondrial DNA (mtDNA) can cause a range of incurable and life-limiting metabolic diseases in humans. Our current study has identified crucial disease associated with genetic variants in the mitochondrial genomes of the Zoroastrian-Parsi community. Our study is a necessary first step to tailor therapeutic strategies that involve targeting validated mitochondrial biomarkers involved in diseases. Given the advent of technologies that enable precise genome editing like CRISPR, we believe our study will benchmark crucial mitochondrial disease-associated variants, classify its prevalence and risk outcomes to complement and tailor therapies that can correct genetic mutations, thus improving patient outcomes in the case of complex genetic diseases like cancers.

How much of your study will pave the path to an era of personalised medicine?

It may be fortuitous that our current study is published on the heels of another study published describing important milestone in editing mitochondrial genomes. Mok, BY et al (Nature, July 2020) has demonstrated the ability to enable precise editing of mtDNA. Our study and its future outcomes will provide a database of mitochondrial variants associated with various conditions to further enhance the possibility of precisely editing the inheritable mutations in mitochondrial genomes, moving the needle towards personalised medicines.

Are there any indicators that may raise caution?

Indeed, any disease associations in a dwindling population is a cause for concern. We show an increased association of variants with conditions like Parkinsons disease, prostate, colon and ovarian cancers, rare diseases resulting in an inherited visual disability like LHON, hearing disability, muscular dystrophy like diseases and infertility. Understanding the molecular mechanisms of these variants resulting in clinical manifestations is extremely important in framing healthcare policies that include precise diagnostic platforms for early disease diagnosis and therapy, steps necessary to arrest the declining numbers in communities like the Zoroastrian-Parsis and other close-knit communities across the world.

What are your predictions for the next five years in cancer biomarker development and validation?

In the next five years, understanding of most cancers would be linked to population genetics and would be individualised into specific groups for treatment. Specific targeted drugs linked to a subset of biomarkers found in each individual patient leading to precision individualised therapies would be the order of the day.

Do you think that there is a need for a cross-disciplinary integration of scientific and clinical expertise for research especially in the field of cancer?

Cross-disciplinary research, especially in cancer, is increasingly relevant and important to reducing that gap in what is identified as best practice and what happens in clinical care. Narrowing this knowledgepractice gap continues to be a slow, complex, and poorly understood process, particularly for research that encompasses the notion of transdisciplinarity, as in the case of complex diseases like cancers. The assimilation of diverse perspectives, research approaches, and types of knowledge is important in helping research teams tackle real-world patient care issues, create more practice-based evidence, and translate the results to clinical and community care settings.

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How genetic studies will become the holy grail to find cancer biomarkers in future - Express Healthcare

14 Ways IoT is Impacting the Food & Agriculture Industry – Appinventiv

The Internet of Things refers to smart devices that are capable of transferring information on a network. Although Kevin Ashton, the acclaimed co-founder, and director of the MIT Auto ID Centre, is credited with inventing the term, it wasnt until 2008 2009 that the concept became widely known.

As internet-enabled devices multiplied in production and installations, there were 12.5 billion internet-connected devices in 2010, so did the general awareness associated with IoT. Fast forward to 2020, there are about 31 billion IoT devices amongst us and a considerably few questions around what is IoT.

As the IoT technology proliferates the marketplace, so does its form and utilities being realized by people in general. And why not? Combined with robotics and AI, the IoT technology hammers out human-dependencies from supply chains and reduces the cost to businesses. Nowhere is this more applicable than perhaps the food industry.

Beginning from the very farm that your food grows in, to the warehouses that store it and the retailers that distribute it, the food service industry has stepped in a new age of remote monitoring, sensing, and action that will have profound, and mostly positive, implications for its supply chain players. Let us find out how.

From disease control measures to cattle and field monitoring systems, IoT is transforming the industry of agriculture by putting the power back where it belongs. Into the farmerss hands. Major sectors where this tech has found a solid footing are indoor farming, livestock management, and aquaculture among others. But how is IoT overcoming challenges and breaking new ground in farming?

Robots have come a long way since the third industrial revolution, abetted by the development of the internet. Although far from changing the face of the F&B industry, agricultural robots aka agribots could offer a circumventing solution to the problem of labor shortages. Unmanned Aerial Vehicles (UAVs) can be deployed to detect and exterminate weeds from the field. They could save farmers time, human resources, and spray volumes by acting precisely as per the demand. This saving translates into a healthy soil that has a lesser amount of pesticides/weedicides to absorb and more positive bacteria to preserve.

Machine learning, GPS, and the internet of things are making manned machine navigation a thing of the past. Farmers can remotely control their tractors, rotavators, and a host of agricultural machinery with a smartphone. As the code memorizes rough patches, it learns to alter gears and smoothen navigation to both protect the crops and the equipment.

Crop harvesting often turns out to be the plight of farmers often due to untimely harvests. Factors influencing such events could be the weather, untrained personnel, or other poor farm management. Harvesting robots could be trained with the wealth of information that we now possess to pick the right fruit at the right time. With the Internet of Things technology, farmers could grow high-value crops at scale than hedge their bets with varieties supported by minimum support prices.

Another way by which the food industry is scaling its appetite for the Internet of Things is by installing on-field sensors. By design, sensors are engineered to detect discrepancies in weather conditions, crop nutrition, soil pH, and more. Such a smartly coded crop monitoring system offers advance intel to farmers and warns them to prepare for exigencies.

Drones are yet another example of IoT in the food industry. The self-guiding technology makes use of GPS, image processing, infrared cameras, and ground control systems. New generation farmers are leveraging Drones-as-a-Service (DaaS) to predict crop yields, diagnose pest infestation, precision fertigation, and field supervision. Aerobotics is one of the few food tech startups that have made their mark in the field, literally. It combines drone scouting and multi-sensor analysis to predict crop health for longevity.

The food manufacturing industry is high on the deployment of the Industrial Internet of Things (IIoT). The two most suited application areas of IoT that have emerged so far are manufacturing and packaging. Both the SMBs and enterprise vendors have realized the value-added, multifold benefits of IoT in the F&B industry and the following sections illustrate further on it.

The use of IoT in warehouse management is known to be a recurrent top IoT trend. Inventory tracking consumes a lot of overheads and unaccounted muscle-power in the food service industry. Massive swathes of data need constant reconciliation and therefore must be accurate. Sensors act as immaculate tracking devices for warehouse inventory, the data pertaining to which is updated in the software real-time. Consequently, the stock loading times are optimized, managers maintain a magnified vigil on supply chains, due to which the storage space is fully taken advantage of.

Automated guided vehicles (AGVs) and collaborative robots can go so far in fetching deeply buried stocks in densely packed shelf lines. So if human intervention cant be uprooted it can surely be made smart and that is what vision picking glasses do. Think Google glass with a lot more information packed in it. Vision picking marries the internet of things with the food industry helping humans identify the right storage zones.

Internet-enabled microchips can be embedded in state-of-the-art food packaging that will expose the originality of the product, once scanned. QR codes are spin-offs of the same concept that evaporate doubts over the authenticity of the product. Especially in times like COVID, customers ordering food online are terrified than ever about the origins of its supply chain. As a result of which an IoT app development company like us is working seriously to offer this feature to our clients.

You never know what customers demand, at least that is what our experience as a food delivery app developer tells us. Integrating QR codes isnt enough. They come in telling us that their stock keeping units are packages with such advanced sensors that indicate not just the veracity of quality but whether the sealing has been broken or not, the source of its ingredients, yadda yadda yadda. For the uninitiated, that is yet another way the internet of things technology is transforming the industry of food.

Modern-day customers love exploring the possibilities associated with food. While sharing the supply chain credentials established trust, offering insights on how to unleash and savor lesser-known recipes takes engagement to impressive levels. As a food app development company, we recommend IoT triggers that inform viewers of add-on combinations to enjoy edible items with. Its a strategic way to augment food packaging with dynamic, ever-changing information that cannot be printed in the first place.

One of the IoT challenges a food delivery app development company like us comes across on our daily roaster is how to make products fly off the shelf without any marketing gimmicks. Turns out we can use IoT (duh!) to run flash-sales for items with low shelf life or those closing in on expiry. Buy one get two offers makes most of us drool.

While open food markets and retailers are the two major platforms for distributing farm produce to consumers, restaurants, road-side eateries, and hotels act as other outlets. Due to this reason, restaurant mobile app developers have been reshifting focus on how to drive IoT in operations. Lets see how businesses can go about their business the smart way with IoT.

For locations that regulate strict recycling legislations, reverse vending machines are a common sight. They incentivize people to deposit disposable/recyclable materials such as cans and plastic bottles by paying them a certain sum. Integrating IoT-enabled programs notifies the retail staff to empty the machine before a queue begins to form. Lesser queues translate into happy customers the lifetime effect of which can be felt in return-customers and their purchase orders.

Refrigeration or storage is a huge concern for the food manufacturing industry. At most locations, operations still depend on the same old, fractured system of human aided supervision. This discounts the fact that the human eye is prone to judgemental errors not to mention the public holidays when the storage units could be under-staffed. IoT-enabled remote monitoring systems can play a cameo in filling such ubiquitous gaps. They can prompt supervisors to action if the temperatures are fluctuating beyond the requisite limits and save precious food. Restaurant app development services like us, can create handheld smart controllers with which the user could moderate temperatures without physical presence.

Temperatures inside large supermarkets, malls, and retail chains are usually regulated by HVAC systems. But they are not intelligent and lack the ability to alter air-conditioning/central heating. An all-encompassing IoT suite could stabilize room temperature in accordance with the outside world. This would help in preserving perishable consumables that cannot bear the brunt of frequent temperature change. In addition, this energy optimization would even save millions of dollars in utility bills contributing further to cost efficiency.

Key Takeaway

The Internet of Things will continue to expand its applications territory into the foreseeable future to varied industries the foremost of which shall remain F&B. Given the well-established line of achievements Appinventiv has won in the years since inception, IoT solutions are definitely up our alley. Lets put it this way, if we dont excite you with our elevator pitch when we meet, the drinks on us. Well be waiting for your call.

Prateek Saxena

Co-founder of Appinventiv

In search for strategic sessions?.

Originally posted here:
14 Ways IoT is Impacting the Food & Agriculture Industry - Appinventiv

The Veronicas On Their First Album In Six Years, ‘Human; – Marie Claire

What Was The Inspiration Behind New Single Biting My Tongue?

Jess: We've been finishing up this album, Human,and the first part of that piece is a big hitter. It's diving into the very human aspects of emotions on this album, and the different human experiences we've been going through. And this one draws on that really peak point of wanting to confess your love for someone that's really visceral. You've tried everything to bury that feeling or keep it in, but now you're at that point where you need to let somebody know. When we're creating a song, we really build an entire world around it, so we see visuals and hear production. And Lisa started this song with DNA and then brought this song to me, and it really embodied the spirit.It's that really fatalistic spirit that become like a bit of a part of how Lisa and I write.

Jess: I don't think that we ever think about our albums comparatively to each other. Rather like a cohesive period of time that embodies whatever we were going through at the time. And although we've been writing this album over a few years, the majority of it was created in a cohesive time period.It feels like a completion of something. It feels like we had all these mini-bursts through this creation. And that whatever shift needed to happen was completed by the end of this writing phase. And each record has felt like that. But our second record and this record, most predominantly for that feeling.

Jess: I don't think it's changed, as far as the dynamic of how Lisa and I love to work. Because it comes down to being as vulnerable as possible. It always has. When we first started songwriting, we were signed as songwriters before we were signed as artists, and it was us sitting on the floor with our guitars. Just writing really personal, intimate thoughts and feelings. Then it's always stayed that. It's just that we've also cultivated new relationships with different songwriters as well. And we have our really great chemistry with people that we're working with for this album.Toby Gad's one of them, and obviously DNA, who we did In My Blood with and Biting My Tongue with. Now as well, You Ruin Me. So when you cultivate that special relationship - because Lisa and I are so comfortable working with each other - when you bring other people in, you have to really trust them as well, because we work so intimately.We're just really blessed that we've had some great relationships with people, and that we continue to be able to create in that safe space.

Lisa:It hasn't hindered anything, but it definitely encourages us to go back to our roots, which is singing and playing guitar.I think, when it all sort of happened, the majority of our live shows did get cancelled.So for us, it became more introspective, and like Jess was saying, the creation process. So rather than focusing on the part where you're on stage, really just giving a lot of energy out. It actually started to go more introspective again and go back to that space of creation, rather than presentation.

And in every aspect of life, we went through that experience of introspection and starting to grow again from the ground up. We spent more time self-reflecting and growing individually, and really thinking about where life is taking us. Getting back on the acoustic guitars and just writing to write with no real urgency or agenda - rather just to feel that moment. And if this has taught us anything, it's that you're just taking day by day and living very much in the moment; because we don't know what the future holds. And there were schedules, and timeframes and expectation all sort of got thrown out the door and we just kind of had to take it day by day; and to really figure out what...There's coping mechanisms for that.

Lisa:It was a new experience. To a certain extent, we were saying, we tend to hermit by nature when we're in creation mode.And then the other half of the year where you become a Veronica, and on your onstage, and you're giving and all that. But the other side of us is, as Jessy said before, Lisa and Jessica are in creation mode.

So I think the year - obviously, for everyone - it was a bit unexpected, but we believe adaptability is the key to longevity. And you have to adapt in these times. It's the mindset. It's the perspective you take and what you do with that time. You can somehow create some sort of positive out of it. It's a way to adapt and survive. So we're very thankful for our health, and the time to spend with family, and each other, and to create again.

Jess: It's is about slowing down a little bit and reflecting, and being able to appreciate a lot. Being grateful for the journey that we've been on, the places that we've been to in the scene. And then try to find new ways to continue to grow. And that's so important for everybody, even while with standing still, what ways can we continue to grow: as people, as a community, as humanity? We're seeing those paradigm shifts greatly in the world right now.

Jess:Yeah. I think as far as the music community, there is a lot of anxiety at the moment. And I think it's just about supporting one another. Our scenes have always had that spirit anyway.So that hasn't really changed, except that I think that it's just more prevalent than ever. And I'm hoping that, it's a test on people's emotional and mental health right now. And I think it's just really important as a community of creatives that we can all be there for one another, first and foremost.

Jess: First and foremost, our Mummy has been our greatest inspiration. From the very beginning, she introduced us to a love of music and of everything that has been of value and importance to us. She was quite the activist, and nurturing person, within the LGBT community; within animal rights. Anything that we have grown to value deeply personally for ourselves, and through The Veronica's work as well, has really been inspired by her head-strength, and her values and morals. So our mums our absolute hero and our greatest inspiration.

Read more from the original source:
The Veronicas On Their First Album In Six Years, 'Human; - Marie Claire

Is having a new puppy like having a newborn in the house? More than I ever appreciated. – Toronto Star

My youngest son, Alister, and I stood by the crate, talking in hushed voices.

Our new puppy, home with us for the first time that afternoon, had gone into the crate an hour ahead of the schedule wed been provided by the breeder.

Is she down for the night, you think? I asked my 13-year-old, like he would somehow know.

I dont know. Maybe?

It was 10 in the evening. The breeder had said she could last from 11 p.m. to 5:30 a.m. in the crate. If she went down now, would she be up at 4:30 a.m.? I wondered aloud with all the uncertainty of a first-time mom to a human baby.

Well, if she is down for the night, well have to close the crate door then, I said, edging toward a decision.

Shell wake up if we close the door, said Alister.

But we cant not close the door ...

In the end we stealthily closed the door and backed out of the room, tiptoeing our way around the creakier parts of the hardwood floor, up the stairs and out of earshot where we could further speculate on Poppys sleep schedule.

It was the start of what has been close to four weeks now of canine caregiving lessons that have opened my two teen boys eyes to some of the responsibilities of parenting better than any episode of Degrassi or a Tamagotchi toy could have done.

With interest in pet ownership skyrocketing during the pandemic while many families have more time at home to bond with and train their new animal and little else to lift their spirits households across the country are in the throes of puppy parenting.

The Toronto Humane Society had a 100 per cent adoption rate of all the animals in its shelter during April and May, compared to 93.5 per cent the same time last year. Reputable dog breeders have wait lists that stretch well into 2021 and beyond.

Everyone tells prospective puppy parents that itll be just like having a newborn in the household again. Subtracting the breastfeeding, colic and diaper changes, theyre more right than I fully appreciated.

The vigilance required for house training and keeping puppies away from choking hazards and other things that shouldnt go in their mouths is a little like being on alert with a newly mobile crawling baby or toddler. The zombie-like fatigue from night waking is definitely reminiscent of early parenting, as is the way our new responsibilities shape dialogue in our home these days.

Now were reporting to each other when our dog last had a pee or poo, how long she napped and when she last ate.

While I work, my boys negotiate off-duty time with each other to do other things, like take a shower or play a little Mario Cart.

We talk about the witching hour when Poppy gets a little hyper and hard to handle in the evening, like a cranky period with a baby. We arrange her daily play dates with the little kids next door and chart her progress on things like responding to the sit command.

And just like isolated new parents stuck at home more than ever, we notice that life is a little easier to handle when were showing off our cute new addition to people we meet on the sidewalk or friends who come by for a socially distanced backyard visit.

Although it happens that welcoming a dog to our home was in the works before COVID-19 hit, the pandemic can present an opportune time to adopt a pet, said Hannah Sotropa, public relations specialist for the Toronto Humane Society.

We really advocate that when youre looking at an adoption, you need to look at especially during this time the longevity of that decision, said Sotropa. COVID-19 will come to an end and when that time does come, looking at whether an animal still suits your lifestyle will be great in setting you, but also the animal, up for success.

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Making it work with a COVID-19 puppy comes down to being proactive as opposed to reactive, she said. That means beginning to prepare your puppy now for life in the after times and whatever sort of return to a previous routine it will bring.

If normally youre out of the house for an eight-hour shift, that means slowly working your pet up to that level of independence.

Using a crate or sanctuary room, possibly gating off an area, get your pet adjusted to being on their own in that space while the family is in other parts of the home, said Sotropa. Work your way up to departures slowly and incrementally.

The other important thing is to spread the responsibilities for your new pet among the members of your household.

Animals often get hyper attached to one person who does most of the walking, the feeding, the loving, said Sotropa.

This person we want to make less significant so that if they do have to go back to work, the animal knows, well, the other members in the house are going to provide me with what I need.

Deena Cooper, who trains and boards dogs through her business DeenaSpeaksDog.com, is already getting calls from people who are in over their heads with the responsibilities of a new puppy. Most of these pets came home during the social distancing period when puppy training classes were mostly suspended or few and far between.

Im getting lots of people wanting me to board and train their dogs; their dogs could be as young as eight weeks old, said Cooper. In some cases these new owners have fond memories of growing up with a dog but are now struggling with a puppy waking them up at night and demanding a lot of attention during the day while theyre also trying to care for their human children.

In other cases the puppies are a bit older and theyve established a lot of crazy behaviours like jumping up, nipping and barking that havent been properly addressed early.

Sotropa asks that anyone still contemplating a pandemic pet adoption think the decision through carefully.

Make no mistake that having an animal is the most rewarding, the most incredible experience; its a bond like youll have with no other, she said. However, they are a commitment and they are a commitment through thick and thin. We dont want to see animals end up back in the shelter.

This article has been changed from a previous version to correct the name of Deena Coopers business.

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Is having a new puppy like having a newborn in the house? More than I ever appreciated. - Toronto Star

A Movie of the Evolving Universe Is Potentially Scary – Scientific American

After the COVID-19 rules about social distancing went into effect, I developed a morning routine of jogging through the woods near my home. During the first months, I focused on the green branches that stretch upward towards the sky, but recently I started to notice the debris of tree trunks lying on the ground. There are many such remnants, eaten by termites, rotting and ultimately dispersing into the underlying soil. A glimpse at the forest reveals a sequence of evolutionary phases in the history of trees that lived or died at different times.

The phenomenon happens in other contexts. For example, I recently completed a nine-year term as chair of the Astronomy Department at Harvard. And only now have I begun to notice the former chairs scattered around me, just like those tree trunks in the woods.

Entering a new stage of life can be humbling. We acquire a false sense of permanence from reviewing the frozen past, as if it were a statue that will never erode. But this view is shortsighted, since each moment can also be seen a new beginning, shaped by forces beyond our control and swirling on a grander scale.

Old-fashioned astronomy was also permeated by a false sense of permanence. Astronomers collected still images of the universe, creating the impression that nothing really changes under the sunor above it, either. But just like the revelation from my stroll through the woods, these snapshots showed stars and galaxies of different ages, at various evolutionary phases along their history. Computer simulations helped us patch together the full story by solving the equations of motion for matter, starting from the initial conditions imprinted on the cosmic microwave background at early cosmic times. By generating snapshots of an artificial cosmos similar to those captured by telescopes, these simulations unraveled our cosmic roots. The scientific insight that emerged is that the likely origins for our existence were quantum fluctuations in the early universe. Perhaps we should add Quantum Mechanics Day to our annual celebrations of Mothers Day and Fathers Day.

There are some missing pages in the photo album made up of our observations, however: the period known as the cosmic dawn, for example, when the first stars and galaxies turned on. These missing pages will be filled in the coming decade by the next generation of telescopes, such as the James Webb Space Telescope (JWST), the ground-based "extremely large" telescopes and the Hydrogen Epoch of Reionization Array (HERA).

To reveal a more literal gap in the sky, the Event Horizon Telescope recently captured a still image of the silhouette of the black hole in the giant galaxy M87. The next goal is to obtain a sequence of images or a video, showing the time variability of the accretion flow around the black hole.

The tradition of still images makes sense when dealing with systems like galaxies, which evolve on a timescale of billions of years. But the universe also exhibits transient fireworks that flare up and dim during a human lifetime. Observing them is the motivation behind the Legacy Survey of Space and Time (LSST) on the Vera C. Rubin Observatory, which will have its first light soon. LSST will be a filming project, documenting nearly a thousand deep multicolor images per patch of the southern sky over a decade and recording the most extensive video of the universe ever taken with its plethora of transients in full glory.

Some of the LSST flares are expected to be the counterparts of gravitational wave sources detected by LIGO/Virgo or LISA. Their discovery will usher in multi-messenger astronomy based on both gravitational and electromagnetic waves emitted by the same sources, providing new insights about the central engines that power these transients. The related standard sirens could serve as new rulers for measuring precise distances in cosmology.

Within the Milky Way, transient events close to Earth could lead to catastrophe. A supernova explosion, for example, could cause a mass extinction on an unprecedented scale. If a meteor similar to the one that hit the unpopulated regions near Chelyabinsk in 2013 or Tunguska in 1908 hit New York City, it could cause a far larger death toll and economic damage than COVID-19. Or consider the impact of a blob of hot gas from the Sun, a so-called coronal mass ejection of the type that missed the Earth in 2012. Such an event could shut off communication systems, disable satellites and damage power grids. Altogether, astronomical alerts about such celestial threats could be crucial for securing the longevity of our species.

Of greatest relevance for our long-term survival is identifying large objects on a collision course with the Earth, similar to the Chicxulub asteroid that killed the dinosaurs 66 million years ago. In 2005, Congress passed a bill requiring NASA to find and track at least 90 percent of all near-Earth objects larger than 140 meters (enough to cause regional devastation) by 2020. Only a third of these objects have been identified in the sky so far. In a recent paper with my undergraduate student Amir Siraj, we explained some puzzling properties of the Chicxulub asteroid as a tidal breakup of a long-period comet that passed close to the sun. If future sky surveys alert us to another fragment whose apparent size grows rapidly against the sky, wed better have a contingency plan to deflect its trajectoryor else immediately call our realtor.

Keeping up with the challenge of precision cosmology for the next few decades can demonstrate that the Hubble constant, which describes the expansion rate of the universe, is not really a constant, in accordance with the expected Sandage-Loeb test. In the long run, the only thing that stays constant is change. The accelerated expansion of the universe under the influence of so-called dark energy will be the ultimate manifestation of extragalactic social distancing in the post-COVID-19 era, preventing any future contact between us and civilizations outside our galaxy.

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A Movie of the Evolving Universe Is Potentially Scary - Scientific American