The Yellen “Resilience” Doctrine Is Dangerous Keynesian Blather

Submitted by David Stockman of Contra Corner blog,

Just when you thought that nothing could be worse than bubble blindness of Greenspan and Bernanke - along comes the Yellen doctrine of resilience. Its dangerous Keynesianblather, and far worse than Greenspans feigned agnosticism which held that the Fed does not have the capacity to recognize financial bubbles in the making and should therefore mop them up after they burst.The Maestronever did say exactlywhat caused the massive and destructive dot-com and housing bubbles which occurred on his watch - except that Chinese factory girls stacked 12-to-a-dorm-room apparently saved way too much RMB.

By contrast, Yellens primitive Keynesian mind knows exactly what causes financial bubbles. Shehas now militantly asserted thatbubblesare entirely an irrational impulse in the privatemarket and that the price of money and debt has absolutely nothing to do with financial stability. Thats right, if the Fed could find a way topeg the money market rate at negative 10% to further its self-defineddual mandateof just enough inflation and always more jobs - even thenany speculative excesses would presumably be attributable tostill another outbreak of the markets allegedpropensity for error, irrationality and greed.

Lets see. If the central bank arranged to cause carry-traders to get paid 8% to borrow short-termmoney (i.e.on anegative 10% deposit rate)in order to fund the carry on junk bonds, Turkish construction loans and the Russell 2000, do ya think they might get a tad rambunctious?For crying out loud, when it comes to speculation, leverage, maturity transformation and re-hypothecation of financial assets the money market interest rates is not nothing as Yellen contends. Its everything!

Thats the heart of the matter and why Keynesian central banking is the most destructive and dangerous doctrine ever invented. In effect, it mandatescentral bankers toseize control of the single most important price in all of capitalismthe price of carry or gambling stakes in the financial markets - and then assertsthat this drastic pre-emption will have no impact on the behavior of speculators, traders and investors.

That predicate is so perverse that it puts one in mind of the boy who killed his parents and then threw himself on the mercy of the courts on the grounds that he was an orphan! Keynesian central bankers like Yellen are doing exactly the same thing. Pegging the money market rate at zero for seven years amounts tokilling all of the financialmarkets inherent stability mechanisms.

That is to say, carry trades are made essentiallyrisk free because the money market rate is officiallypegged at zero. Moreover,the Fed has furtherpromised to be utterly transparent in notifying gamblers as to when the spread between their funding cost and their asset yield will change, and with ample advance notice.

Furthermore, the downside risk on the asset side of the trade is also substantially removed. Owing to the long-standing Greenspan/Bernanke/Yellen put the cost of protection against sharp declines in the broad market (such as the S&P 500 index) has become dirt cheap. In effect, the Fed is massively subsidizing the cost of put options that allow speculators to insulate their risk asset positions.

Accordingly, momentum dealsandcarry trades are far more profitable than they would be on an honest free market because in the latter case market-priced insurance premiums would eat up far more of the winnings. Needless to say, out-sized and artificial profitability attracts massive excess capital and resources into the hedge fund and trading deskgambling arenasthe very motor forces of financial instability.

Likewise, an essential ingredient of honest two-way financial markets is speculation from the short-side. Self-evidently, ZIRP, bond market repression and the Feds stockmarket put have driventhe short interest out of the casino entirely.So now we have one-way markets that are inherently prone to powerful speculative excess.

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The Yellen "Resilience" Doctrine Is Dangerous Keynesian Blather

WorldReligionNews.com Featured Contributor Series Continues With Hinduism, Scientology, Islamic and Spirituality …

San Francisco, CA (PRWEB) July 03, 2014

WorldReligionNews.com continues its featured contributor series with 4 articles from a varied collection of authors representing either official religions or organizations.

This most recent addition of 'Featured Contributor' articles includes: Rajan Zed, representing the Universal Society of Hinduism, discussing a historical Hindu invocation in Maryland; Ro W, of the Quranist blog Muslim Reformation, asserting his opinions on blasphemy and apostasy laws; Keith Wommack, syndicated columnist and Christian Scientist explaining the connections between health, good listening, and spirituality; and finally, Tad Reeves, Scientology Parent website writer, with an interview about raising children as a Scientologist parent.

Read these 'Featured Contributor' articles and others here: http://www.worldreligionnews.com/featured-contributors/.

WorldReligionNews.com has established its Featured Contributor program to offer both writers officially affiliated with all faiths and belief systems, as well as independent writers, bloggers, journalists and authors of note, a public platform from which to publish religion focused articles that will reach not only WRN visitors but also appear via syndication partners on sites like CNN, FOX, New York Daily News and others.

If you are an officially affiliated spokesperson/writer for a particular religious organization or, a prominent writer, blogger journalist of note who would like to be considered for a Featured Contributor article placement on WRN, contact us here: http://www.worldreligionnews.com/guest-blogger-submission/.

About WorldReligionNews.com: WRN exists to cover the news generated by all major world religions, A to Z, from Agnosticism to Wicca and all in between, in ways that will inspire, enlighten, entertain & engage within a framework wired for a connected and distracted world.

http://www.WorldReligionNews.com

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WorldReligionNews.com Featured Contributor Series Continues With Hinduism, Scientology, Islamic and Spirituality ...

Genetic engineering paving way for futuristic healthcare

Mysore, July 3, 2014, DHNS:

Rajya Sabha member Prof Rajiv Gowda onThursday asserted that there were many advantages to mankind through the study of genes.

Addressing the gathering of researchers at the opening of Know Your Genome, a laboratory, at RaniBahadurAuditorium in the city, Gowda said, the findings of genetic engineering was laudable, especially in protecting ones health.

However, there were also dangers of misusing the same, eventually leading to legal complications.

Though the study of genetics was exorbitant, there were still ways to reach the same to the common man.

Visiting Professor of IISc, Bangalore,HARanganath stressed that genetics studies be included in the syllabus to equip the students with the basics of the subject.

Ranganath exhorted the University of Mysore to start a department and research centre in genetics studies, to produce a pool of young experts. The lab

A dedicated laboratory was been opened in Vijayanagar in the city on Thursday.

The lab, Know your genome helps one ascertain the diseases he/she can be afflicted with in advance, and the required treatment.

According to its founderAvinash Veerappa, said that tests will be conducted in two levels by collecting samples of blood and mucus.

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Genetic engineering paving way for futuristic healthcare

Tennessee Pharmacist Robert Harshbarger, lll Recently Spoke at Junes Health Symposium in Kingsport, TN

Kingsport,TN (PRWEB) July 04, 2014

Performance Medicine (Dr. Tom Rogers) and Custom Compounding Centers of America hosted The Truth about Testosterone in association with June being Mens Health Month. The mens health gathering was standing room only and was held at 109 Jack White Drive, Kingsport, TN on June 24, 2014. The public was welcome.

There were several notable speakers who covered various mens health topics; for example: exercise, nutrition, and hormones, which all play key roles in total health. Men dont have to feel like they have been sentenced to feeling like they barely exist due to lack of energy, low libido, and/or depression just to name a few symptoms. I tell my patients we are all guilty of doing nothing; this is the worst thing they can do for their future health and it places them in their own personal prison. We have medical knowledge, studies and information available to help men that we didnt have in past years. We offer a wide variety of nutritional supplements and compounded medications to treat different patient situations, stated Robert Harshbarger, Pharmacist.

According to the American Diabetes Association, as many as 13 million men in the United States may have low testosterone levels and more than 90 percent of them are not being treated. Among those men, some 70 percent report having trouble maintaining erections, a condition called erectile dysfunction, and 63 percent report having a low sex drive.

Testosterone is a steroid hormone that helps regulate sperm development, maintain muscle mass, and boost energy. Both men and women have it, but men produce about ten times more of it than women. Low testosterone is sometimes known as androgen deficiency syndrome; androgen is the term for the male sex hormone and testosterone is the main sex hormone for men.

State and federal healthcare costs have risen in monumental amounts as our overweight and aging population continues to grow and all the cost that goes along with it. This is a real problem that we need to deal with starting today. Its a Win/Win for men; they will look, feel and have better odds of a long life and healthier outcome. I feel passionate speaking to patients about precautionary measures they can take and I get charged up when I counsel patients about lifestyle," said Dr. Harshbarger.

About Custom Compounding Centers of America: Custom Compounding Centers of America is locally owned and operated and has proudly served the Tri-Cities, TN region for over 24 years. CCCA has the knowledge, experience and resources, which include a state of the art facility, that are elite in the industry. CCCA has been making patient specific specialty medications and servicing thousands of patients both locally and nationally over the years. Robert (Bob) Harshbarger, Pharmacist concluded, We strive to set new standards of excellence for our patients and physicians, thats our commitment. For more information visit http://www.cccarx.com

About Performance Medicine: Dr. Tom Rogers is a national speaker for male hormone replacement; he promotes healthy lifestyles to his patients through his passion for fitness and nutrition. He has a fellowship from the American Board of Anti-Aging and Regenerative Medicine, and has practiced medicine in the Tennessee region for over 28 years.

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Tennessee Pharmacist Robert Harshbarger, lll Recently Spoke at Junes Health Symposium in Kingsport, TN

UCLA Awarded $7 Million to Unravel Mystery Genetic Diseases

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Newswise The David Geffen School of Medicine at UCLA is one of six institutions nationwide chosen by the National Institutes of Health to join their effort in tackling the most difficult-to-solve medical cases and develop ways to diagnose rare genetic disorders. Part of a $120 million initiative called the Undiagnosed Diseases Network, the four-year $7.2 million UCLA grant will enable comprehensive bedside to bench clinical research to support physicians efforts to give long-sought answers to patients who have been living with mystery diseases.

Undiagnosed diseases take a huge toll on patients, their families and the health care system, said Dr. Katrina Dipple, a co-principal investigator of the grant with Drs. Stanley Nelson, Christina Palmer and Eric Vilain. This funding will accelerate and expand our clinical genomics program, enabling us to quickly give patients a firm diagnosis and clarify the best way to treat them.

Despite extensive clinical testing by skilled physicians, some diseases remain unrecognized because they are extremely rare, underreported or atypical forms of more common diseases. An interdisciplinary team of geneticists at each of the network sites will examine and study patients with prolonged undiagnosed diseases.

A vast number of children and adults suffer from severe, often fatal undiagnosed disorders, explained Vilain. This program will enable us to discover new genes causing ultra-rare medical conditions and to identify environmental factors that lead to disease or interact with genes to cause disease.

Patients will undergo an intensive week-long clinical assessment that includes a clinical evaluation, consultations with specialists and medical tests, including genome sequencing to identify genetic mutations. The team will also evaluate the impact of genetic counseling and genomic test results on patients and families to develop best practices for conveying this information.

The Undiagnosed Diseases Network capitalizes upon the strengths of UCLAs genetic medicine program, particularly its Clinical Genomics Center, which utilizes powerful sequencing technology to diagnose rare genetic disorders. Using a simple blood sample from a patient and both parents, the test simultaneously searches 37 million base pairs in 20,000 genes to pinpoint the single DNA change responsible for causing a patients disease. To date, a specific genetic explanation has been identified in a quarter of the cases evaluated with this test, as well as a number of novel disease-causing genes.

UCLA is the only facility in the western U.S. and one of only three nationwide that has a laboratory that can perform genomic sequence directly usable for patient care. The UCLA Medical Genetics Clinic cares for more than 750 new patients per year, and offers comprehensive pre- and post-test genetic counseling.

All patient studies will take place on the university campus at the Clinical Translational Research Center of the Clinical and Translational Science Institute. Network investigators will share genomic and clinical data gleaned from patients with their research colleagues nationwide to enhance understanding of rare and unknown diseases.

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UCLA Awarded $7 Million to Unravel Mystery Genetic Diseases

Scientists engineer nanoparticles to prevent bone cancer, strengthen bones

PUBLIC RELEASE DATE:

30-Jun-2014

Contact: Marjorie Montemayor-Quellenberg mmontemayor-quellenberg@partners.org 617-534-6383 Brigham and Women's Hospital

Boston, MA A research collaboration between Brigham and Women's Hospital (BWH) and Dana-Farber Cancer Institute (DFCI) has utilized nanomedicine technologies to develop a drug-delivery system that can precisely target and attack cancer cells in the bone, as well as increase bone strength and volume to prevent bone cancer progression.

The study is published the week of June 30, 2014 in Proceedings of the National Academy of Sciences.

"Bone is a favorable microenvironment for the growth of cancer cells that migrate from tumors in distant organs of the body, such as breast, prostate and blood, during disease progression," said Archana Swami, PhD, BWH Laboratory of Nanomedicine and Biomaterials, co-lead study author. "We engineered and tested a bone-targeted nanoparticle system to selectively target the bone microenvironment and release a therapeutic drug in a spatiotemporally controlled manner, leading to bone microenvironment remodeling and prevention of disease progression."

"There are limited treatment options for bone cancers," added Michaela Reagan, PhD, DFCI Center for Hematologic Oncology, co-lead study author. "Our engineered targeted therapies manipulate the tumor cells in the bone and the surrounding microenvironment to effectively prevent cancer from spreading in bone with minimal off-target effects."

The scientists developed stealth nanoparticles made of a combination of clinically validated biodegradable polymers and alendronate, a clinically validated therapeutic agent, which belongs to the bisphosphonate class of drugs. Bisphosphonates bind to calcium. The largest store of calcium in the human body is in bones, so bisphosphonates accumulate in high concentration in bones.

By decorating the surface of the nanoparticles with alendronate, the nanoparticles could home to bone tissue to deliver drugs that are encapsulated within the nanoparticles and kill tumor cells, as well as stimulate healthy bone tissue growth. Furthermore, bisphosphonates are commonly utilized during the treatment course of cancers with bone metastasis, and thus alendronate plays a dual role in the context of these targeted nanoparticles.

The scientists tested their drug-toting nanoparticles in mice with multiple myeloma, a type of bone cancer. The mice were first pre-treated with nanoparticles loaded with the anti-cancer drug, bortezomib, before being injected with myeloma cells. The treatment resulted in slower myeloma growth and prolonged survival. Moreover, the researchers also observed that bortezomib, as a pre-treatment regimen, changed the make-up of bone, enhancing its strength and volume.

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Scientists engineer nanoparticles to prevent bone cancer, strengthen bones

Opinion: The Soul of Man under Secularism

(Kumar Ketkar is a senior journalist, political commentator, globe trotter and author. He has covered all Indian elections since 1971 and significant international events. He is a frequent participant on TV debates.)

The title of this piece, paraphrased from Oscar Wilde's 'The Soul of Man Under Socialism' would contradict the very essence of the idea of 'Secularism'. The secularists are not supposed to believe in the existence of 'soul'. It is presumed that they have scientific temper and do not believe in any prevailing religion. They may have been born to some religion - Hindu, Muslim, Christian, Sikh etc, but they profess to be secularists. The secularists are either atheists or at least agnostics.

But the Indian version, or rather the Congress version of secularism is essentially respect (or appease) all religious communities. That is why it was translated by a section of Indian intellectuals as "Sarva-Dharma-Samabhava". It tried to emphasize co-existence and tolerance of all faiths, rather than scientific temper or agnosticism / atheism. Under this system, all religions are allowed to not only practice publicly but also propagate their religious beliefs. The pragmatic and politically convenient definition of "secular" is just being "anti-communal".

The otherwise sober Congress leader A K Anthony has stirred a hornet's nest by openly saying that Congress secularism has come to mean appeasement of the minorities. So the definition of secularism was not merely anti-communalism but being overtly pro-minorities. It hardly needs to be stressed that the term minorities is often used as synonymous for Muslims. Anthony himself is a Christian and therefore a member of the minority community. But despite being a Congressman, he too used the term appeasement to mean Muslims. It was the unkindest cut of all.

Actually, a similar critical comment was made by late Vithalrao Gadgil, the then spokesperson of the Congress, in 1998-1999, when the BJP-led NDA came to power, but it did not generate as much controversy. The debate has now reopened because Anthony is a head of the committee set up to investigate the causes of the disastrous defeat of the Congress. Also, the defeat in 1998-99 was not as catastrophic as now. It is natural therefore that the BJP and the conservative Hindu pundits have quickly taken up Anthony's statement and pounced on the rather vague idea of secularism as practiced by the Congress.

Oscar Wilde had observed, in the context of the idea of socialism that, "Admirable but misdirected intentions, they very seriously and very sentimentally set themselves to the task of remedying the evils, but their remedies do not cure the disease, they merely prolong it. Indeed their remedies are part of the disease". This observation aptly describes the fate of political secularism in the country today.

For the past 30 years or more, this form of secularism is under siege. Broadly, the organizations or parties believing in the idea of 'Hindutva' or 'Hindu Rashtra' were considered "communal" and hence all other parties, from the Congress to Communists, from Samajwadi Party to the BSP, were regarded as secular. Muslims are not a monolithic community, as most of the Sangh Parivar believes. In fact, the Shia Muslims are supposed to be with the BJP, even in Gujarat. The Bohra Muslims are openly backing Narendra Modi.

Psephologists say their research shows that the so-called Muslim Vote Bank is a media-created myth. The Uttar Pradesh election proves that even the Muslims voted the BJP in a significantly large number. However, there is a strong "secular" view that majoritarianism has prevailed and there was massive Hindu vote consolidation. It is also true that there is tremendous apprehension about this election and there is a lot of fear, frustration and a feeling of getting reduced to secondary citizenship.

For the first time the number of Muslim members of Parliament has been reduced to a single digit. The BJP does not have a single Muslim MP. The only Muslim minister, Najma Heptulla is a non-elected member of the party, and she has complicated the issue of "minority community" by saying that only the Parsis can be considered a minority. Even the Parsis were not impressed by Najma's statement.

Those people who have visited Gujarat feel the state and the so-called development model have not reached out to the Muslims in refugee camps. Modi often says "all are Indians " and he does not distinguish between Tamilians and Punjabis, Bengalis and Marathis. The experience of Gujarat is that it is psychologically divided. There is a huge "trust deficit" between the state government and the Muslim community. It is also easy to say that the people, mainly the Muslims, must "move on" and not keep the injury of 2002 bleeding. Gujarat has a very bloody history of communal riots and just because some intellectuals and pundits want to "move on" does not mean the Muslims will be persuaded to believe a new era of "genuine secularism" has arrived after nearly 60 years of "pseudo-secularism".

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Opinion: The Soul of Man under Secularism

Nancy Kress: How Science Fiction Helps Us Rehearse for the Future

Stephen Cass: Hello, Im Stephen Cass for IEEE Spectrums Techwise Conversations.

Nancy Kress is a celebrated author of science fiction and fantasy novels and short stories. First published in 1976, her work often focuses on the implications of genetic engineering and other biomedical technologies. Among other awards, she has won five Nebulas from the Science Fiction & Fantasy Writers of America.

As part of its 50th anniversary celebrations this August, Spectrum will be publishing Coming Soon Enough, an anthology of six original science fiction stories, including one by Kress titled Someone to Watch Over Me. But you dont have to wait to read it: The story is available now as part of Spectrums June special issue about the long-term future of technology.

Without giving anything away, Someone to Watch Over Me is a dark tale about the unintended consequences of advanced biomedical implant technology. To talk about the story and the broader themes that run throughout her work, Kress joins us now by phone from her home in Seattle. Nancy, welcome to the podcast.

Nancy Kress: Thank you. Im glad to be here.

Stephen Cass: So what was the inspiration for Someone to Watch Over Me?

Nancy Kress: I often write about children. The next generation of any society is, of course, what carries it forward. But in addition, we are faced right now with so many interesting possibilities, with genetic engineering and in other technologies as well, that the generation being born now is growing up far different than, say, the way I did. Texting, to me, would have seemed unimaginable. To them, its just normal ho-hum everyday kind of things. So when I was thinking about this story, I was thinking about cameraswhich, of course, are a far next generation of Google Glassthat actually fit in the eye and are not noticeable to anybody else or even possibly to the wearer, except in that they are recording. I naturally turn to the idea of a child wearing one, and I asked myself, What child? Under what circumstances? And from there the story grew. I frequently do start with a character.

Stephen Cass: So how closely do you then follow real-world technological developments? You mentioned Google Glass, which is an emerging technology

Nancy Kress: Im not trained as a scientist, which I deeply regret. When I was in high school, I didnt have chemistry because it conflicted with French 4, and now I cant do chemistry or speak French. It was a great tragedy. However, I try to keep up with the journals that are written for laymen, and when something captures my attention, Ill try to get the latest books on it. And I also collect microbiologists the way some people collect butterflies.

And I have a list of people that I can ask questions of when something captures my attention. So its kind of hit and miss whether some emergent technology comes to my attention. But if it does, and if it also succeeds in capturing that attention, then I try to find out about it in anyplace thats available to me.

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Nancy Kress: How Science Fiction Helps Us Rehearse for the Future

Editorial: Fanning GMO fears

Published: Wednesday, July 2, 2014 at 6:01 a.m. Last Modified: Tuesday, July 1, 2014 at 4:29 p.m.

Genetic engineering is such a polarizing topic that it is hard to have an even-handed debate of the issue.

Some opponents of genetically modified organisms, or GMOs, spread false claims about safety while ignoring the vast amount of research to the contrary.

That frustrates University of Florida researchers who have made advances in genetic engineering that might provide benefits in fighting crop diseases and reducing the need for pesticides if they could get beyond public misconceptions.

As The Sun reported this week, UF researchers have taken a gene found in bell peppers and transferred it to tomatoes. The process has made tomatoes that are resistant to a particularly troublesome crop disease and have a higher yield.

Contrary to scare stories about Frankenfoods, these methods represent a more technologically advanced way of doing the kind of crop breeding that has happen for millennia.

But Florida tomato growers worry they wouldn't be able to sell a GMO product, hampering the ability of researchers to attract investors.

"People are afraid, they don't understand why, they are just told they should be," Sam Hutton, a UF plant scientist involved in the research, told The Sun. "The anti-GMO crowd screams really loud, and there is a lot of fearmongering. It sounds bad to people who don't understand the science."

Other GMOs being developed at UF include a strawberry that can be grown without fungicides. A researcher involved in that effort told The Sun that the crop likely won't go beyond the lab without a change in public attitudes.

"You have solutions that can help the environment, help farmers and help people in the developing world, and you can't use it," said Ken Folta, professor and chairman of UF's Horticultural Sciences Department.

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Editorial: Fanning GMO fears

Christof von Kalle, M.D., Ph.D. receives Pioneer Award

PUBLIC RELEASE DATE:

1-Jul-2014

Contact: Kathryn Ruehle kruehle@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, July 1, 2014Christof von Kalle, MD, PhD (National Center for Cancer Research, Heidelberg, Germany) began his medical and research career with a focus on oncology and virology. He subsequently devoted much of his efforts to studying the use of viral vectors to deliver therapeutic genes into host cells and understanding the mechanisms of insertional mutagenesis. In recognition of his leadership and accomplishments, Dr. von Kalle has received a Pioneer Award from Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Human Gene Therapy is commemorating its 25th anniversary by bestowing this honor on the leading 12 Pioneers in the field of cell and gene therapy selected by a blue ribbon panel* and publishing a Pioneer Perspective by each of the award recipients. The Perspective by Dr. von Kalle is available on the Human Gene Therapy website.

In "Vector Integration and Tumorigenesis," Dr. von Kalle recalls his early experiences working with retroviral vectors and the growing body of knowledge that was developing about their ability to cause mutations at the sites where they integrated into the host cell genome. He discusses the teamwork, intensive research, and technology advances that led to a growing understanding of the link between vector insertion, mutation, and malignant transformation of cells. Tracing the progress of the field forward to the present and looking to the future, Dr. von Kalle comments on the revolutionary impact that next generation sequencing technologies, molecular tools and techniques, and omics studies are having on gene therapy.

"The level of sophistication that Dr. von Kalle has brought to the analysis of vector integration is truly remarkable," says James M. Wilson, MD, PhD, Editor-in-Chief of Human Gene Therapy, and Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia. "This has established a solid scientific foundation to a critically important performance feature of retro- and lenti-based vectors."

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*The blue ribbon panel of leaders in cell and gene therapy, led by Chair Mary Collins, PhD, MRC Centre for Medical Molecular Virology, University College London selected the Pioneer Award recipients. The Award Selection Committee selected scientists that had devoted much of their careers to cell and gene therapy research and had made a seminal contribution to the field--defined as a basic science or clinical advance that greatly influenced progress in translational research.

About the Journal

Human Gene Therapy, the Official Journal of the European Society of Gene and Cell Therapy, British Society for Gene and Cell Therapy, French Society of Cell and Gene Therapy, German Society of Gene Therapy, and five other gene therapy societies, is an authoritative peer-reviewed journal published monthly in print and online. Human Gene Therapy presents reports on the transfer and expression of genes in mammals, including humans. Related topics include improvements in vector development, delivery systems, and animal models, particularly in the areas of cancer, heart disease, viral disease, genetic disease, and neurological disease, as well as ethical, legal, and regulatory issues related to the gene transfer in humans. Its sister journals, Human Gene Therapy Methods, published bimonthly, focuses on the application of gene therapy to product testing and development, and Human Gene Therapy Clinical Development, published quarterly, features data relevant to the regulatory review and commercial development of cell and gene therapy products. Tables of content for all three publications and a free sample issue may be viewed on the Human Gene Therapy website.

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Christof von Kalle, M.D., Ph.D. receives Pioneer Award

Behavioral therapy in pediatric antidepressant treatment reduces likelihood of relapse

PUBLIC RELEASE DATE:

2-Jul-2014

Contact: Debbie Bolles debbie.bolles@utsouthwestern.edu 214-648-3404 UT Southwestern Medical Center

DALLAS July 2, 2014 Cognitive behavioral therapy in addition to medication improves the long-term success of treatment for children and adolescents suffering from depression, a new UTSouthwestern Medical Center study indicates.

Based on the results of a clinical trial conducted at UTSouthwestern and Children's Medical Center of Dallas, depression relapse rates were substantially lower in a group of youth who received both forms of treatment versus medication alone.

"Continuation-phase strategies designed to reduce the high rates of relapse in depressed youths have important public health implications, as recurrence of depression is more likely in youths with multiple episodes," said Dr. Betsy Kennard, Professor of Psychiatry at UTSouthwestern and senior author of the study published June 17 in The American Journal of Psychiatry.

Relapse rates in youth with major depressive disorders typically range from 40 percent to 70 percent, said Dr. Kennard, also Director of an outpatient program at Children's Medical Center called Suicide Prevention and Resilience at Children's (SPARC).

In this study, the relapse rate for the group of 75 youth who received behavioral therapy for six months following six weeks of initial treatment with the antidepressant fluoxetine, also known as Prozac, was 9 percent. Among the group of 69 youth who received only the drug during this period, 26.5 percent relapsed.

Youth who showed improvement after receiving fluoxetine for an initial six-week treatment period continued in the study, split between the medication-only and therapy plus medication groups. Study participants' ages ranged from 8-17.

"Unfortunately, medication alone is not always enough to prevent relapse," said Dr. Graham Emslie, Chief of the Division of Adolescent and Child Psychiatry, Professor of Psychiatry and Pediatrics at UTSouthwestern, and a contributing author of the study. "Identifying novel strategies to prevent future relapses for young people should be a priority. This approach is unique in that treatment was added at a time when the intensity of care is frequently decreasing."

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Behavioral therapy in pediatric antidepressant treatment reduces likelihood of relapse

Behavioral Therapy Added to Pediatric Antidepressant Treatment Reduces Likelihood of Relapse

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Newswise DALLAS July 2, 2014 Cognitive behavioral therapy in addition to medication improves the long-term success of treatment for children and adolescents suffering from depression, a new UTSouthwestern Medical Center study indicates.

Based on the results of a clinical trial conducted at UTSouthwestern and Childrens Medical Center of Dallas, depression relapse rates were substantially lower in a group of youth who received both forms of treatment versus medication alone.

Continuation-phase strategies designed to reduce the high rates of relapse in depressed youths have important public health implications, as recurrence of depression is more likely in youths with multiple episodes, said Dr. Betsy Kennard, Professor of Psychiatry at UTSouthwestern and senior author of the study published June 17 in The American Journal of Psychiatry.

Relapse rates in youth with major depressive disorders typically range from 40 percent to 70 percent, said Dr. Kennard, also Director of an outpatient program at Childrens Medical Center called Suicide Prevention and Resilience at Childrens (SPARC).

In this study, the relapse rate for the group of 75 youth who received behavioral therapy for six months following six weeks of initial treatment with the antidepressant fluoxetine, also known as Prozac, was 9 percent. Among the group of 69 youth who received only the drug during this period, 26.5 percent relapsed.

Youth who showed improvement after receiving fluoxetine for an initial six-week treatment period continued in the study, split between the medication-only and therapy plus medication groups. Study participants ages ranged from 8-17.

Unfortunately, medication alone is not always enough to prevent relapse, said Dr. Graham Emslie, Chief of the Division of Adolescent and Child Psychiatry, Professor of Psychiatry and Pediatrics at UTSouthwestern, and a contributing author of the study. Identifying novel strategies to prevent future relapses for young people should be a priority. This approach is unique in that treatment was added at a time when the intensity of care is frequently decreasing.

The type of therapy used in this trial called Relapse Prevention Cognitive Behavioral Therapy is an individual psychotherapy treatment with a family component that focuses on reducing residual symptoms, increasing wellness behaviors, and preventing relapse. For six months, the youth in this arm of the trial participated in eight to 11 therapy sessions that were tailored to each child.

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Behavioral Therapy Added to Pediatric Antidepressant Treatment Reduces Likelihood of Relapse

Why It’s Never Been More Important to Pick Your Mobile Platform Wisely

Is moving from one mobile OS to another a big deal? The platform you choose today could have ramifications in the future,

Will your choice of phablet determine the mobile ecosystem you get locked into for health and fitness tracking, automobile navigation and home entertainment?

I've been mulling this questions since I saw Google's flurry of news at its 2014 I/O conference this week. More on that in a second. First, let's start with Apple, which is expected to release two big-screened iPhone 6 phones this fall, one model at 4.7 inches and another at 5.5 inches.

Apple's current iPhone 5 models max out at 4 inches and can't compare to Samsung's army of phablets, including the Samsung Galaxy Note 3 (5.7-inch screen) and the Galaxy Mega (6.3 inches). But will supersized Apple phones lure phablet fans away from their Samsungs?

I doubt we'll see a mass exodus, becasue there are many happy Samsung phablet users out there. Still, a few trends are worth noting:

This could mean there will be a fair amount of Android-to-iOS switchers this fall. Moving from Android to iOS or vice versa may not seem like a huge deal -- until you consider the future of both platforms.

Recent announcements from Apple (at its WWDC developer conference) and Google (at I/O) clearly illustrate that their mobile ecosystems are poised to expand far beyond smartphones and tablets in the near future.

Both Apple and Google are busy integrating health and fitness apps, APIs and smartwatch/fitness trackers into their respective ecosystems. Both are vying to become your car's mobile OS. Android TV is coming to a set-top box near you later this year to compete against, among others, Apple TV, as well as the physical Apple television the company is said to be building. Don't even get me started on the "Internet of Things," as part of which refrigerators, toaster ovens, crockpots and other everyday appliances will no doubt soon be hooked into and controlled by apps within the Android and iOS ecosystems. The goal of both companies is to deeply interconnect the various devices on their platforms so that, for instance, you can control your TV set with your smartwatch.

As the months and years tick by, the Apple and Google platforms will undoubtedly invade many areas of our lives. Of course, it's quite possible to live with one foot planted in each ecosystem. I do. But the benefits of mobile OS agnosticism will likely reach diminishing returns over time, forcing most people into one camp or the other.

So if you find yourself mulling a jump from Android to iOS or the other way around, choose carefully. Whichever road you take, the further you go, the harder it will be to turn back.

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Why It's Never Been More Important to Pick Your Mobile Platform Wisely

St. John’s wort can cause dangerous interactions with many common medications

PUBLIC RELEASE DATE:

30-Jun-2014

Contact: Kathryn Ruehle kruehle@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, June 30, 2014St. John's wort is the most frequently used complementary and alternative medicine (CAM) treatment in the U.S. for depression and similar psychiatric disorders. The many commonly prescribed medications that St. John's wort can interact withsometimes with serious consequences such as serotonin syndrome or heart diseaseare reviewed in The Journal of Alternative and Complementary Medicine, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on The Journal of Alternative and Complementary Medicine website.

In the article "Use of St. John's Wort in Potentially Dangerous Combinations", Scott Davis, Steven Feldman, MD, PhD, and Sarah Taylor, MD, Wake Forest Baptist Medical Center, Winston-Salem, NC, present the results of a large-scale search of a national medical database across 17 years to assess how often St. John's wort is prescribed and taken with other medications that may result in adverse reactions, such as oral contraceptives, selective serotonin reuptake inhibitors (SSRIs), blood thinners, chemotherapy medicines, digoxin, statins, immunosuppressants, or HIV medicines, for example.

About the Journal The Journal of Alternative and Complementary Medicine is a monthly peer-reviewed journal publishing observational, clinical, and scientific reports and commentary intended to help healthcare professionals and scientists evaluate and integrate therapies into patient care protocols and research strategies. Complete tables of content and a sample issue may be viewed on The Journal of Alternative and Complementary Medicine website.

About the Publisher Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Alternative & Complementary Therapies, Medical Acupuncture, Brain and Gut, and Journal of Medicinal Food. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers.

Mary Ann Liebert, Inc. 140 Huguenot St., New Rochelle, NY 10801-5215 Phone: (914) 740-2100 (800) M-LIEBERT Fax: (914) 740-2101 http://www.liebertpub.com

Contact: Kathryn Ruehle, Mary Ann Liebert, Inc., (914) 740-2100, kruehle@liebertpub.com

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St. John's wort can cause dangerous interactions with many common medications

New method to grow zebrafish embryonic stem cells can regenerate whole fish

PUBLIC RELEASE DATE:

30-Jun-2014

Contact: Kathryn Ruehle kruehle@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, June 30, 2014Zebrafish, a model organism that plays an important role in biological research and the discovery and development of new drugs and cell-based therapies, can form embryonic stem cells (ESCs). For the first time, researchers report the ability to maintain zebrafish-derived ESCs for more than 2 years without the need to grow them on a feeder cell layer, in a study published in Zebrafish, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Zebrafish website.

Ho Sing Yee and coauthors from the Malaysian Ministry of Science, Technology and Innovation (Pulau Pinang), Universiti Sains Malaysia (Penang), and National University of Singapore describe the approach they used to be able to maintain zebrafish stem cells in culture and in an undifferentiated state for long periods of time. The ability to establish and grow the zebrafish ESCs without having a feeder layer of cells to support them simplifies their use and could expand their utility. In the article "Derivation and Long-Term Culture of an Embryonic Stem Cell-Like Line from Zebrafish Blastomeres Under Feeder-Free Condition", the authors show that the ESCs retain the morphology, properties, and ability to differentiate into a variety of cell types that is characteristic of ESCs, and were used to generate offspring after transmission through the germline.

"By addressing a major technical bottleneck in the field, this new culture system enables an array of exciting cellular and molecular genetic manipulations for the zebrafish," says Stephen Ekker, PhD, Editor-in-Chief of Zebrafish and Professor of Medicine at Mayo Clinic, Rochester, MN.

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About the Journal

Zebrafish is an authoritative peer-reviewed journal published bimonthly in print and online. It is the only peer-reviewed journal to focus on the zebrafish and other aquarium fish species as models for the study of vertebrate development, evolution, toxicology, and human disease. Tables of content and a sample issue may be viewed on the Zebrafish website.

About the Publisher

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New method to grow zebrafish embryonic stem cells can regenerate whole fish

Global Nanomedicine Market: Industry Analysis, Size, Share,Growth, Trends, and Forecast 2013 – 2019

Albany, New York (PRWEB) June 30, 2014

This report includes market estimations for nanomedicine market for the forecast period 2013 2019. The nanomedicine market size is represented in terms of USD billion, and the market estimates and forecasts are calculated considering 2012 as the base year. Moreover, the trends and recent developments of the nanomedicine market have been kept into account while forecasting the market growth and revenue for the period 2013 2019.

Browse the full Nanomedicine Market Report: http://www.transparencymarketresearch.com/nanomedicine-market.html

The overall nanomedicine market is segmented on the basis of applications and geography, and the market estimations for each of these segments, in terms of USD billion, is provided in this report.

The nanomedicine market, on the basis of applications, is segmented into neurological, cardiovascular, oncology, anti-inflammatory, anti-infective and other markets. The nanomedicine market is also estimated and analyzed on the basis of geographic regions such as North America, Europe, Asia-Pacific and the rest of the world. The global trends such as drivers, restraints, and opportunities of the global nanomedicine market is detailed in the market overview chapter of this report, with a view on impact of these factors on market growth along the course of the forecast period.

For further inquiries, ask here: http://www.transparencymarketresearch.com/sample/sample.php?flag=S&rep_id=1753

The chapter on competitive landscape consists of heat map analysis of the key players operating in the global nanomedicine market. Some of the key players of this market include GE Healthcare, Mallinckrodt plc, Nanosphere Inc., Pfizer Inc., Merck & Co Inc., Celgene Corporation, CombiMatrix Corporation, Abbott Laboratories and others. The role of these market players in the global nanomedicine market is analyzed by profiling them on the basis of attributes such as company overview, financial overview, product portfolio, business strategies, and recent developments.

The global nanomedicine market is categorized into the following segments:

Nanomedicine Market by Application

Nanomedicine Market by Geography

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Global Nanomedicine Market: Industry Analysis, Size, Share,Growth, Trends, and Forecast 2013 - 2019