Frost & Sullivan recognises Intersec for aiming its ROI-driven data solutions at telecommunications providers

Based on its recent research on the big data solutions market, Frost & Sullivan presents Intersec with the 2014 African Customer Value Leadership Award.

At the core of Intersecs success is its ability to maximise hardware usage through highly efficient software design implementation. Soon after its inception, Intersec made an important decision to target telecommunications operators to help them develop innovative capabilities and service platforms. It particularly sought to enable mobile operators to capture and monetise the value inherent in their networks, through the efficient processing of big data.

Intersec has demonstrated the ability to efficiently address telecommunications providers needs, including deriving ways to monetise their customer data with internal and external usage, identifying their target audience for associated and derived services, and thrashing out the most effective ways of using them.

Using Intersecs solution, operators can build their own rules-based systems to automatically respond to particular user events and context. This means that the processed big data can provide actionable insights and fully personalised applications such as customer retention management (loyalty and churn); real-time, contextual engagement; and location mapping.

Intersecs service is founded on the companys desire to cut through the complexity of big data and provide simple, targeted vertical solutions that are easy to deploy, said Frost & Sullivan Senior Industry Analyst Gareth Mellon.

Messaging (of various forms) is still the key means of communication between operators and users, particularly in emerging markets such as Africa. In this environment, Intersecs system provides added value to operators by opening up multiple communication channels including SMS, MMS, unstructured supplementary service data (USSD,) cell broadcast centre (CBC,) interactive voice response (IVR) and email.

Another characteristic of Intersecs solution is its agnosticism, both in terms of system and device inputs. Indeed, it is even able to capture non-cellular network data, further enhancing its value to operators that might provide multiple means of access. Intersecs creation of a single framework also breaks down information silos, which is a recurring problem for companies seeking to implement big data solutions.

In terms of implementation, Intersec aims to provide incremental benefit and hence, avoid direct competition with larger, integrated providers, noted Mellon. Its initial value proposition is to improve internal efficiencies (notably, effective real-time customer value management and retention solutions) and demonstrate the systems worth before progressing to new revenue streams and business models.

Intersec provides solutions with capacity for add-on services, as software activation of these additions is relatively easy. Its solutions have already been adopted by numerous operators across Africa and its innovative approach to product development will add to its growing momentum in the African market.

Each year, Frost & Sullivan presents this award to a company that has demonstrated excellence in implementing strategies that proactively create value for its customers with a focus on improving the return on the investment that customers make in its services or products. The award recognises the company's inordinate focus on enhancing the value that its customers receive, beyond simply good customer service, leading to improved customer retention and ultimately customer base expansion.

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Frost & Sullivan recognises Intersec for aiming its ROI-driven data solutions at telecommunications providers

Why RSS up in arms against genetically modified (GM) crops?

Field trials of 15 genetically modified crop, widely known as GM crop may be delayed after Swadeshi Jagran Manch(SJM) and Bharatiya Kisan Sangh(BKS) raised serious objection about the feasibility of the whole process. The biotech regulator, Genetic Engineering Approval Committee (GEAC) on July 18 had given its nod for field trails of number of GM crops including rice, mustard and cotton. Both, SJM and BKS are the two wings of RSS, BJP's parental organisation. A delegation of the organisation on Tuesday met Union Environment and Forests Minister Prakash Javadekar regarding the issue and expressed their concern about the long term impact of GM crops on human health and soil. Meanwhile, the Environment Minister has assured them that no decision will be taken in hurry. "We will not rush into it. We will hold consultations with the stakeholders before taking any decision", Javadekar said.

Here is the whole issue in detail.

What is the GM crop? That crop in which original genetic make-up is artificially changed through genetic engineering method is called GM crops. The purpose of the modification is to introduce new traits which were not available in original genetic set up. These crops are also known as transgenic crops. The new introduced traits help in providing resistance against certain diseases and other environmental conditions thereby increases productivity of particular crops. At present, Bt Cotton is the only GM crop which has been allowed to be grown commercially in India.

What is the take of anti-GM crop people? They believe that these crops might pose risks to the environment and human health. Rejects the perception that farmers will be largely be benefitted with the move. This group of people maintains that, it will encourage the monopoly of agri-biotech companies through seed marketing. Our own farmers have to cough up more money every year to buy fresh seeds as these patented GM one have a limited life span of one year only.

What pro-GM crop people are saying? These people have this opinion that such crops would rejuvenate agricultural productivity which will ultimately lead to food security. This group ourightly rejects the report that such crops have any adverse effect on human health and environment

What Supreme Court had said? The Supreme Court in its decision (April, 2014) had sought an answer from the Central Government on the same. The Court had asked from Centre, why there should not be an interim suspension of field trials of these GM crops as experts are largely going against it. The Court said, "We have reports of responsible persons who occupy responsible positions. Don't you think there should be an interim order (against open field trials) till we hear this case?" Earlier in July 2013, the SC appointed committee had recommended an indefinite halt on field trials of such crops till the government fixes regulatory and safety aspects regarding the issue.

What was UPA's stand? Erstwhile Government had maintained perplexing stand on the controversial issue during its tenure. While former Environment Minister Jayanthi Natarajan was against the GM crops, her successor M Veerappa Moily favoured the same. According to the DNA report, during Moily's tenure (2013-14), around 60 proposals of field trials for these GM crops were cleared by GEAC.

Story first published: Wednesday, July 30, 2014, 12:46 [IST]

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Why RSS up in arms against genetically modified (GM) crops?

The promise and profits driving our pill-popping culture

PUBLIC RELEASE DATE:

30-Jul-2014

Contact: Kathryn Ruehle kruehle@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, July 30, 2014We have pills to ease pain, to cure infection, to help us lose weight, to treat chronic conditions, and to enhance our sexual and athletic prowess. Why do pills play such a central role in today's society and could we benefit from taking fewer pills? This provocative topic is explored in the article "'Take Your Pill': The Role and Fantasy of Pills in Modern Medicine," published in The Journal of Alternative and Complementary Medicine, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on The Journal of Alternative and Complementary Medicine website.

Coauthors Drew Leder, MD, PhD, Loyola University (Baltimore, MD) and Mitchell Krucoff, MD, Duke University Medical Center (Durham, NC), discuss why pills are such "ideal consumer items" and offer the promise to solve so many of life's problems. They describe some of the adverse effects of pill-taking and of the "exaggerated cultural fantasy" surrounding pills in modern medicine. While many pills offer important therapeutic effects, they should be used more selectively, suggest the authors, and viewed as a "gift."

"As a healing construct pills concentrate both biochemical and symbolic power," says Dr. Krucoff, an Executive Editor of the Journal, "however like most powerful things, their place in modern culture can be unbalanced when the healing context is subverted by priorities like financial gain."

###

About the Journal

The Journal of Alternative and Complementary Medicine is a monthly peer-reviewed journal publishing observational, clinical, and scientific reports and commentary intended to help healthcare professionals and scientists evaluate and integrate therapies into patient care protocols and research strategies. Complete tables of content and a sample issue may be viewed on The Journal of Alternative and Complementary Medicine website.

About the Publisher

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The promise and profits driving our pill-popping culture

Youth digest — July 30

Szelag on UNC dean's list

GREELEY, Colo. -- Kyla Szelag of Columbus has been named to the dean's list of distinction for the 2013-14 academic year at the University of Northern Colorado.

Dean's list qualifications require a 3.75-4.0 grade point average in any two terms of the year.

BELLEVUE -- Bellevue University acknowledges the accomplishments of students who have earned degrees from January through June 2014.

Graduates include the following students from local communities: Columbus - Rachelle Benson, master of business administration; Rose Kavulak, BS in behavioral science; Brittany Newill, bachelor of science in criminal justice administration, cum laude; Calan Reppert, bachelor of science in criminal justice administration; Deanna Soulliere, bachelor of science in business; Thomas Yrkoski, bachelor of science in business.

COLUMBUS - Seventy-seven students participated in the Central Honors Institute July 13-18 at Central Community College-Columbus.

Participants will be entering the seventh or eighth grade this fall and have demonstrated a high ability in language arts, math and/or science. They were selected on the basis of their academic accomplishments, leadership skills and maturity as well as a recommendation from a teacher or counselor.

In addition to attending classes, camp participants had a chance to socialize with peers in the evenings and experience life on a college campus. Terry Wulf of Columbus supervised the social activities.

Participants from local schools include the following: CHI Creativity Track - Clarkson Public School: Libby Crecco, daughter of Josie and Ron Crecco of Clarkson; Columbus Christian School: Madeline Fremarek, daughter of Jill and Jeff Fremarek of Columbus; Lakeview: Emily Stevenson, daughter of Denise and Ken Stevenson of Richland; Columbus Middle School: Faith Dill, daughter of Susan Pospisil and Scott Schuld of Columbus; Allie Gotschall, daughter of Tammi and Jeff Gotschall of Columbus; Emily Hall, daughter of Kristel and Greg Hall of Columbus; Samantha Huerta, daughter of Marlene Cordon and Junior Huerta of Schuyler; Alexis Jeffryes, daughter of Trina and Michael Jeffryes of Columbus; Abby Marshall, daughter of Amanda Mancini Marshall of Columbus; Lucas Miller, son of Nicole and Matthew Miller of Columbus; and Jalynn Olson, daughter of Angela and Corey Olson of Columbus; Aquinas: Lindsey Nickolite, daughter of Tami and Paul Nickolite of Bellwood, and Jill Witter, daughter of Jo and James Witter Jr. of David City; Twin River: Kelsey Swantek, daughter of Annette and Marc Swantek of Genoa; Schuyler: Connor Bywater, son of Christina and Brian Bywater of Schuyler, and Anna Rocheford, daughter of Bobbie Jo and Pat Rocheford of Schuyler.

CSI at CHI Track Lakeview: Kyle Mohrmann, son of Lela and Tim Mohrmann of Columbus, and Ethan Vinson, son of Becky and Quinn Vinson of Columbus; Columbus Middle School: Douglas Davidchik, son of Sarah and Daniel Davidchik of Columbus; Michaela Graham, daughter of Barb Graham of Columbus; Taylor Howerter, daughter of Deanna and Mark Howerter of Columbus; Paige Jeffryes, daughter of Trina and Mike Jeffryes of Columbus; Autumn Tindall, daughter of Jenny Tindall of Columbus; and Ashley Warner, daughter of Brandi and Curt Warner of Columbus; Scotus Central Catholic: Hannah Allen, daughter of Kimberly and Michael Allen of Columbus, and Elliott Thomazin, son of Kelli and John Thomazin of Columbus; Leigh: Alexis Schroeder, daughter of Sharon and Ronald Schroeder of Leigh; Shelby-Rising City: Angelina Rodriguez, daughter of Paula and BJ Barcel of Bellwood.

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Youth digest -- July 30

DNA Explains Political Preference, New Research Claims

New York, NY (PRWEB) July 30, 2014

Anyone who has ever wondered why the gulf between conservative and liberal views seems so unbridgeable might find some answers in the latest issue of Behavioral and Brain Sciences.

In a fascinating article, Differences in negativity bias underlie variations in political ideology, three political scientists argue that our political bias is frequently not a conscious choice nor the result of our upbringing, but a product of predispositions rooted in our psychology and even our biology.

Drawing on a growing body of research and on their own experiments, John Hibbing and Kevin Smith from the University of NebraskaLincoln, and John Alford from Rice University, Texas, make the claim that personality, psychology, physiology, and genetics each play an important role in whether individuals will turn out to have conservative or liberal leanings.

Using experiments in which people were shown nice or nasty images or asked to judge facial expressions, the authors found that participants of a conservative bent reacted faster and spent longer engaging with negative images than testees who defined themselves as liberals. The unsavory images included spiders, burning houses, and a maggot-infested wound, and each subjects reactions were gauged by monitoring devices such as eye trackers, which measure involuntary responses.

Hibbing writes:

The logic for our approach is straightforward. Life is about encounters: sights, sounds, smells, imaginings, objects, and people, and the systems employed to sense, process, formulate, and execute a response to stimuli are psychological and physiological. Even if a stimulus is identical, one individual will sense, process, and respond to it differently than another.

We reason that this variation is likely to correlate with the political positions endorsed by each individual. Across research methods, samples, and countries, conservatives have been found to be quicker to focus on the negative, to spend longer looking at the negative, and to be more distracted by the negative.

This negativity bias could explain why typical conservatives traits are preference for stability and order, which keep in check potentially threatening change, while liberals are more likely to embrace innovation and reform and the uncertainty and potential chaos they may bring.

Hibbing includes a warning against the temptation to base value judgements on the findings:

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DNA Explains Political Preference, New Research Claims

Beware of claims about cosmetic stem cells procedures, says review in Plastic and Reconstructive Surgery

PUBLIC RELEASE DATE:

29-Jul-2014

Contact: Connie Hughes Connie.Hughes@wolterskluwer.com 646-674-6348 Wolters Kluwer Health

July 29, 2014 Advertising claims for cosmetic procedures using stem cells are running far ahead of the scientific evidence for safety and effectiveness, according to a review in the August issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons (ASPS).

"Stem cells offer tremendous potential, but the marketplace is saturated with unsubstantiated and sometimes fraudulent claims that may place patients at risk," write Dr Michael T. Longaker of Stanford University Medical Center and colleagues.

'Worrying advertisements' for cosmetic stem cell procedures

Dr Longaker and coauthors raise concerns about the unregulated use of stem cells for unproven indicationsincluding cosmetic procedures. While stem cell therapy "remains in its infancy," they write, "there are a growing number of cosmetic practitioners that are advertising minimally invasive, stem cell-based rejuvenation procedures."

The article was prompted by "worrying advertisements" claiming benefits of stem cell procedures for facelifts, breast augmentationeven "stem cell vaginal rejuvenation." These ads claim benefits from procedures that have not undergone rigorous scientific evaluationincluding potential risks related to stem cell and tissue processing and the effects of aging on stem cells.

To gain insight into these claims, Dr Longaker and coauthors performed a Google search for cosmetic stem cell treatments, the most common of which was "stem cell facelifts." Most procedures used "stem cells" isolated from fat. However, the websites provided little information on the quality of the stem cells used.

Without advanced cell-sorting procedures, these products used in these procedures likely contain many other types of cells besides fat-derived stem cells. Many clinics also offered plasma-rich platelet protein treatments, which they inaccurately marketed as stem cell therapy.

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Beware of claims about cosmetic stem cells procedures, says review in Plastic and Reconstructive Surgery

Indoor and Outdoor Sun Tanning or Sun Burns Directly Linked to Deadly Melanoma Skin Cancer

BOCA RATON, Fla., July 30, 2014 /PRNewswire/ --Today the US Surgeon General issued the most stern warning to date for indoor and outdoor sun tanning or sun burns stating they can lead directly to deadly melanoma skin cancer. In his statement Surgeon, General Boris Lushniak, says that "skin cancer is a major public health problem for all skin types and that too much exposure to indoor and outdoor ultraviolet light is a major cause." At the Rendon Center for Dermatology and Aesthetic Medicine, in Boca Raton, Florida, Marta I. Rendon, MD, Board Certified Dermatologist, specializes in the prevention and treatment of skin cancer. "Many people experience their first sun burn in South Florida and then need to seek treatment," states Dr. Rendon who advises "prevention as the best remedy: keeping sun exposure to a minimum, wearing protective clothing including a hat and lots of sunscreen and to always avoid tanning beds." Nearly 6000 cases of melanoma skin cancer were directly attributed to tanning beds in 2013.

However as skin cancer cases in the US continue to increase Dr. Rendon and her staff are prepared to treat all types of skin cancer. She says that "if you are diagnosed with skin cancer we have the very latest treatments and state of the art equipment available today to treat your specific skin cancer." Dr. Rendon is also the only dermatologist in Boca Raton, Florida to implement the newest cutting-edge technology for non-melanoma skin cancer called the SRT-100 by Sensus, a painless, non-invasive device that successfully removes non-melanoma skin cancer.

With the latest Surgeon General warnings against exposure to ultra violet rays Dr. Rendon says "it is more important than ever to minimize sun exposure and have annual body scans to look for and detect any possible skin cancer early when it is most treatable."

About the Rendon Center for Dermatology and Aesthetic Medicine

The Rendon Center for Dermatology & Aesthetic Medicine inBoca Raton, Florida, was founded by Marta I. Rendon, MD, a world-renowned, board-certified dermatologist.The Rendon Center offers the full complement of dermatologic services from anti-aging treatments to skin cancer removal. Dr. Rendon and her team of highly respected dermatologists provide unparalleled aesthetic and dermatologic treatments, using cutting-edge technologies and advanced techniques to provide their patients with the best results possible. http://www.drrendon.com

Media Contact: Fern Cole: F.Cole@admcorp.com

The Rendon Center for Dermatology and Aesthetic Medicine 880 N.W. 13th St., Suite 3C Boca Raton, FL 33486-2342 Phone: (561) 750-0544 Fax: (561) 750-9873 http://www.drrendon.com

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Indoor and Outdoor Sun Tanning or Sun Burns Directly Linked to Deadly Melanoma Skin Cancer

Shelton firms products in the pipeline could end diseases

A company specializing in the emerging field of nanomedicine has opened in Shelton, offering the possibility that major healthcare advances could be developed in the city.

U.S. Rep. Jim Himes cuts the ribbon at the new NanoViricides facility in Shelton while joined by company officials, including President and Chairman Anil R. Diwan, Interim Chief Financial Officer Meeta Vyas and Chief Executive Officer Eugene Seymour.

The products being produced here could very well end diseases such as influenza and dengue fever, U.S. Rep. Jim Himes said at this weeks opening of the NanoViricides Inc. facility on Controls Drive.

This is truly a game changer for humankind, Himes said.

He predicted the companys president and chairman, Anil R. Diwan, could even win the Nobel Prize in medicine if products now in development at NanoViricides succeed.

Diwan said the firm has six medicines in the pipeline that would treat the flu, dengue, HIV, herpes (cold sores) and eye viruses.

With money raised from investors, NanoViricides has bought the 18,000-square-foot building at 1 Controls Drive, near Long Hill Cross Road. The company is now moving its facilities and employees there from West Haven.

The Shelton site will include manufacturing areas, labs, research-and-development space and offices. The building offers a lot of room for expansion.

It will be the only nanomedicine clinical product manufacturing facility in Connecticut.

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Shelton firms products in the pipeline could end diseases

Why Android Wear is worth watching

Let's talk about a version of Android that you wear. We're right at the beginning in the miniaturization of technology. You're gonna talk to your wrist. How tall is Barack Obama? It's finally possible to make a powerful computer small enough to wear comfortably all day long. Google's Android Wear is a compact version of an operating system that really has to do three things. Run well on new devices like smart watches, get manufacturers to buy into that market and get consumers to do the same thing. And Google pretty much delivered on almost every rumor we predicted and their full roll out of Android where with big time support coming out of the gates with the LGG watch and Samsung's [INAUDIBLE]. Just one more tap to pay. And the pizza's on its way. The pretty gorgeous stainless steel and leather banded watch. It's here. Your watch will also provide intelligent answers to spoken questions. He can even check his heart rate after a jog. Now, Android Wear on its own actually does very little. A Smartwatch running it, like a Samsung Gear Live or an LG G watch, has to first pair to a late model Android phone. No Windows phone, no iPhone support here. Once that pairing is done, your watch starts to get fed the content it needs for some very simple notifications and basic interactions. Like reminders of your next appointment, or simple guidance to get somewhere, like your next appointment. Messages and easy ways to reply, weather forecasts coming up, payment confirmations, travel status updates. Now these are just some basic early use cases and, of course, an Android Wear's functionality is limited only to what developers can come up with, which isn't much of a limitation at all. But note the mode is to have very simple swipe and voice interactions between menus and information screen. There's no keyboard on that watch. Now the first watches out with Android Wear are the predictably nerdy Samsung Gear Live and LGG watch. More interesting is the pending Motorola 360. This is a watch with a round face and a very jewelry like look. Andre Ware is able to map it's display and interface to the actual round display. Not just crudely crop it. That's important, because many, like myself, believe that a key part of SmartWatch success, on any platform, is gonna be the ability for watch designers to really spread out aesthetically and not be limited to square text style displays. Another big step forward with Android Wear is a degree of agnosticism. In the past, most smart watches, short past, I should point out, only worked with their own family of phones. Early Samsung smart watches only worked with Samsung Galaxy phones, and not even all of those. That's not a formula for success. Going forward Android Wear will allow the watch to work with any ANdroid phone running 4.3 of the Operating System, or newer, but still no Windows Phone, I-Phone, or Blackberry coordination. Its early days of course were the smart watches. Not to mention the Android wear subset of them. That's it. Here is my memo to the Android wear team as well as the manufacturer's building Onyx. First make it smarter. Right now we feel the early Android wear watches are kind of giving scatter shot display of information and content, it doesn't really seem to map to my moment in the day as well as it could. Let's filter better. Make it indispensable. This is still very much a luxury market. Nobody can't live without an Android Wear smart watch. Let's find the really important use cases so it goes beyond the novelty stage. We need to extend battery life. We all have enough devices right now that get plugged in every day. And look like jewelry. Once you get past that first million geeks and earlier adopters, nobody's gonna buy a smartwatch that looks like they strapped a smartphone on their wrist. It is, of course, too soon to predict the growth curve for Android wear let alone the broader smartwatch market, for a number of reasons. First of all, Apple hasn't even entered this space yet. Secondly, most consumers have no idea what we're talking about. Thirdly, the battle between fitness bands and smart watches has to be sorted out. And there's an awful lot of overlap there. But for now, at this moment, Android Wear seems to be the biggest bear in a small, growing, and rapidly changing wood.

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Why Android Wear is worth watching

How sweet it is: Bioenergy advanced by new tool

A powerful new tool that can help advance the genetic engineering of "fuel" crops for clean, green and renewable bioenergy, has been developed by researchers with the U.S. Department of Energy (DOE)'s Joint BioEnergy Institute (JBEI), a multi-institutional partnership led by Lawrence Berkeley National Laboratory (Berkeley Lab). The JBEI researchers have developed an assay that enables scientists to identify and characterize the function of nucleotide sugar transporters, critical components in the biosynthesis of plant cell walls.

"Our unique assay enabled us to analyze nucleotide sugar transporter activities in Arabidopsis and characterize a family of six nucleotide sugar transporters that has never before been described," says Henrik Scheller, the leader of JBEI's Feedstocks Division and a leading authority on cell wall biosynthesis. "Our method should enable rapid progress to be made in determining the functional role of nucleotide sugar transporters in plants and other organisms, which is very important for the metabolic engineering of cell walls."

Scheller is the corresponding author, along with Ariel Orellana at the Universidad Andrs Bello, Santiago, Chile, of a paper describing this research in the Proceedings of the National Academy of Sciences (PNAS). The paper is titled "The Golgi localized bifunctional UDP-rhamnose/UDP-galactose transporter family of Arabidopsis." The lead authors are Carsten Rautengarten and Berit Ebert, both of whom hold appointments with JBEI, and both of whom, like Scheller, also hold appointments with Berkeley Lab's Physical Biosciences Division. (See below for the full list of co-authors.)

The sugars in plant biomass represent an enormous potential source of environmentally benign energy if they can be converted into transportation fuels -- gasoline, diesel and jet fuel -- in a manner that is economically competitive with petroleum-based fuels. One of the keys to success in this effort will be to engineer fuel crops whose cells walls have been optimized for sugar content.

(From left) Berit Ebert, Carsten Rautengarten and Henrik Scheller at JBEI have developed an assay for characterizing the functions of nucleotide sugar transporters in plant cell walls. (Photo by Irina Silva, JBEI)

With the exception of cellulose and callose, the complex polysaccharide sugars in plant cell walls are synthesized in the Golgi apparatus by enzymes called glycosyltransferases. These polysaccharides are assembled from substrates of simple nucleotide sugars which are transported into the Golgi apparatus from the cytosol, the gel-like liquid that fills a plant cell's cytoplasm. Despite their importance, few plant nucleotide sugar transporters have been functionally characterized at the molecular level. A big part of the holdup has been a lack of substrates that are necessary to carry out such characterizations.

"Substrates of mammalian nucleotide sugar transporters are commercially available because of the medical interest but have not been available for plants, which made it difficult to study both nucleotide sugar transporters and glycosyltransferases," Scheller says.

For their assay, Scheller, Rautengarten, Ebert and their collaborators, created several artificial substrates for nucleotide sugar transporters, then reconstituted the transporters into liposomes for analysis with mass spectrometry. The researchers used this technique to characterize the functions of the six new nucleotide sugar transporters they identified in Arabidopsis, a relative of mustard that serves as a model plant for research in advanced biofuels.

"We found that these six new nucleotide sugar transporters are bispecific, which is a surprise since the two substrates are not very similar from a physical standpoint to the human eye," Scheller says. "We also found that limiting substrate availability has different effects on different polysaccharide products, which suggests that cell wall polysaccharide biosynthesis in the Golgi apparatus of plants is also regulated by substrate transport mechanisms."

In addition to these six nucleotide sugar transporters, the assay was used to characterize the functions of 20 other transporters, the details of which will soon be published.

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How sweet it is: Bioenergy advanced by new tool

SAGE(r) Labs Licenses CRISPR/Cas9 Technology from the Broad Institute

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Newswise ST. LOUIS, July 29, 2014 /PRNewswire/ -- SAGE Labs Inc., a leading provider of products, services and technologies in the field of genome engineering, announced today that they have licensed CRISPR/Cas9 technology from the Broad Institute. The license enables SAGE Labs to use the CRISPR/Cas9 system to engineer cell and animal models for their clients as well as distribute validated CRISPR reagents. This is the second license obtained by SAGE Labs around CRISPR/Cas9 technology; SAGE also obtained a license from Caribou Biosciences in September 2013.

The Broad Institute was recently issued the first patent for CRISPR/Cas9 technology based on the research of Feng Zhang, PhD, published in Science in January of 2013. CRISPR/Cas9 technology represents the latest advancement in nuclease-based gene editing tools, which have revolutionized genetic engineering by markedly reducing development times and enabling genetic engineering in potentially any species.

David Smoller, PhD., CEO of SAGE Labs, explained, "At SAGE Labs we use the latest technologies to provide our clients with the most advanced models of human disease, and in the shortest timelines possible. It's also essential that our clients receive the freedom-to-operate with their research models, and we're committed to obtaining the necessary licenses."

About SAGE Labs

SAGE Labs is a leading provider of advanced gene editing tools, research models, and support services. Harnessing the latest technologies for genome engineering including Zinc Finger Nucleases (ZFN) and CRISPR/Cas9, SAGE produces complex research models in less than half the time as conventional technologies. In addition, SAGE Labs is a premier source for custom-designed and stringently validated CRISPR/Cas9 reagents. For more information, visit http://www.sageresearchlabs.com.

About the Broad Institute of MIT and Harvard: The Eli and Edythe L. Broad Institute of MIT and Harvard was launched in 2004 to empower this generation of creative scientists to transform medicine. The Broad Institute seeks to describe all the molecular components of life and their connections; discover the molecular basis of major human diseases; develop effective new approaches to diagnostics and therapeutics; and disseminate discoveries, tools, methods, and data openly to the entire scientific community.

Founded by MIT, Harvard, and its affiliated hospitals, and the visionary Los Angeles philanthropists Eli and Edythe L. Broad, the Broad Institute includes faculty, professional staff and students from throughout the MIT and Harvard biomedical research communities and beyond, with collaborations spanning over a hundred private and public institutions in more than 40 countries worldwide. For further information about the Broad Institute, go to http://www.broadinstitute.org.

CONTACT:

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SAGE(r) Labs Licenses CRISPR/Cas9 Technology from the Broad Institute

PM for greater research in agriculture, RSS linked outfits oppose GM crop

New Delhi: Two Rashtriya Swayamsevak Sangh (RSS) linked outfits on Tuesday sought a ban on field trials of genetically-modified crops cleared by biotech regulator Genetic Engineering Approval Committee (GEAC) on a day when Prime Minister Narendra Modi pressed for greater use of research for boosting the agriculture sector.

However, the government said that it is yet to take a final call. Sources said that it has assured RSS affiliated outfits that it will deal with the issue of GM crops with caution, adding that no decision will be taken in haste.

Representatives of Swadeshi Jagran Manch and Bhartiya Kissan Sangh on Tuesday met the Environment Minister Prakash Javadekar on the issue of field trials of GM crops of certain varieties of rice, brinjal and cotton among others. The outfits claim that the minister assured them that the decision about field trials of GM crops has been "put on hold".

They apprised him about their concerns while claiming that the Minister assured them that the decision about field trials of GM crops has been "put on hold". "The minister assured the delegation that the decision about the field trials of GM crops has been put on hold by the government," All-India co-convener of the Manch Ashwani Mahajan said.

When contacted, Javadekar confirmed the meeting but asserted that the government has not taken any decision on the contentious issue. He said that GEAC has taken such a decision but government has not acted upon it yet.

"The government has not taken any decision on the contentious issue. The government will not take any decision in haste," he said. The Genetic Engineering Approval Committee (GEAC) had earlier this month cleared 15 proposals for confined field trials for rice, brinjal, chickpea, mustard and cotton.

The delegation reminded the minister that Parliamentary Standing Committee on Agriculture in its report on GM food crops - prospects and impacts, tabled in Parliament on August 9, 2013 has clearly recommended the 'stopping of all field trials under any garb'.

The Manch and Sangh members told the minister that it is "not advisable" to allow GM crops without proper scientific evaluation about their probable long term impact on human health and soil. They said, "The technology, which involves introducing a 'foreign' gene, is dangerous because once introduced, it is irreversible. Once you have a GM crop, you cannot reverse the process if you find that it is causing harm."

They contended that there is no scientific study to prove that GM technology does increase productivity as is claimed by the promoters of the technology. They also pointed out that environmental costs might outweigh any benefits that the introduction of such a technology brings. The delegation told the minister that there is major issue of food security of the nation attached to this issue.

The Manch urged the minister that government should not rely on the biased and manipulated reports of vested interests among the industry and institute enquiries about the likely impact of GM food crops on soil, human and other species' health to ensure that no harm is done to traditional gene pool and biodiversity of the nation, soil, food security and health of the people of India.

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PM for greater research in agriculture, RSS linked outfits oppose GM crop

One day we may live twice as long as we do today!

My late father, as was so common in his generation, had a heart attack in his 40s, a stroke in his 50s and succumbed to heart disease in his early 60s.

After a heart attack at age 55, I felt confident I was likely to follow the path of my father and grandfather (who died at age 59), and not live much beyond my mid-60s. Perhaps because of my lifestyle and the miracles of modern medicine, I am 71 and feel 40, fabulous and frisky!

Not surprisingly, we all want to live very long lives. There is even the promise by some expert gerontologists (scientists who study the aging process) of life expectancies of a century and a half. Longevity has become a passion. Industries have evolved that promise youth, reversal of the aging process and a prolongation in life expectancy. Much is cosmetic and only skin-deep, with anti-aging creams, diets to reduce wrinkling and promote youth, and an explosive increase in cosmetic surgery to avoid the inevitable growing older.

Interest in longevity has led to a new health care field called anti-aging medicine that promises youthfulness, longer lives and the tantalizing promise of immortality. Today sales pitches from purveyors of dubious natural and pharmaceutical products promise longer and better lives. Interest in this area has grown explosively with over 10,000 physicians belonging to the American Academy of Anti-Aging Medicine, a driving force in so-called longevity medicine. The evidence that any current therapy can reverse aging is doubtful or frankly nonexistent. Politicians have referred to anti-aging advocates as 21st-century snake oil salesmen, and some years ago Dr. Jay Olshansky of the University of Illinois circulated a position paper signed by 51 of the nations most eminent scientists warning of the hype of anti-aging remedies.

Anti-aging therapies include sex and growth hormones that have the potential of building muscle and strength, but they accelerate rather than prevent aging. Antioxidants, vitamins, minerals and immune-boosting medications have all been proposed as anti-aging therapies. More and more evidence is accumulating that these, including vitamin E, vitamin C, vitamin A, various minerals and many others increase cancer risk and shorten rather than increase life expectancy.

While reversing the aging process is currently impossible, never say never! We know that restricting food intake in animals prolongs life by about 30 percent, and as we learn more and more about how individual cells function, new strategies to reverse aging are possible. The tip of every chromosome is referred to as the telomere. As a cell ages, the telomere shortens, and this prevents the cell from dividing. Once the telomere is very short the cell dies. Research has shown that an enzyme known as telomerase can prevent telomere shortening and prolong the life expectancy of cells. Much research is currently underway to use this strategy to prolong life in animals and perhaps one day in man. To date, this had not been achieved.

Even more exciting is the ongoing research by world-renowned and highly respected gerontologists who have identified genes in worms, fruit flies, mice and even monkeys that prolong life. By the use of cutting edge research, these genes can be modified, prolonging life expectancy in these organisms by 50 percent or more. Finding a single gene or a number of linked genes that can either be altered or injected into humans to reverse the aging process may one day be a reality. Who knows what the future may hold? The incredible sophistication of modern-day research technologies makes anything possible.

Even if no more than a promise for the future, these research endeavors to prolong life are vital to truly understanding the factors involved in longevity. A longer life will only work if we minimize or eradicate chronic diseases that cause disability, such as frailty and Alzheimers disease. This will assure not only a longer but, more importantly, a better life. Simultaneously, we must prevent the leading causes of death, including heart disease, cancer, chronic lung and kidney disease.

If we all live beyond 100, and 90 percent of us reside in nursing homes, living longer will be accompanied by suffering, depression and unrealistic economic burdens. It is not how long we live but how well.

Dr. David Lipschitz is the author of the book Breaking the Rules of Aging.

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One day we may live twice as long as we do today!

Ethos Spa Skin and Laser Center Adds Fractional Lens Array for PicoSure Laser for Fine Line and Sun Spot Removal …

SUMMIT, NJ (PRWEB) July 28, 2014

Ethos Spa Skin and Laser Center now offers the first-of-a-kind anti-aging benefits of the PicoSure FOCUS lens array at its Summit and Englewood locations. This new, non-invasive treatment leverages the powerful photomechanical effect of the PicoSure laser to diminish and remove sun spots, fine lines, wrinkles, enlarged pores, redness and hyperpigmentation while improving the skins texture.

According to Ethos Spa Medical Director Hardik Soni, M.D., the FOCUS skin revitalization system is 20 times more powerful than other anti-aging lasers. By focusing more precisely on small areas of the skin, surrounding tissue is left untouched and gently protected, making it gentler and safer than other lasers to provide superior results with less discomfort, less downtime, and less risk.

The PicoSure laser system uses picosecond (trillionth of a second) technology with the powerful photomechanical effect pressure wave and the FOCUS lens array to concentrate the laser pulse on imperfections that age a persons appearance. FOCUS skin revitalization is also the latest answer to improving skin laxity, ruddiness and acne scars, and can be used to revitalize skin on any body area including the neck, shoulders, back, chest, arms and hands.

PicoSure costs $750 per treatment, and two to four treatments may be necessary to achieve ideal results. Post-treatment downtime is minimal. Treated areas may be sensitive for a couple of hours, and the next day there may be some redness.

For more information on the FOCUS skin rejuvenation treatments or any of the expert aesthetic services available at the Ethos Spa, Skin and Laser Center, visit the Ethos Spa website, call the Summit location at (908) 273-5400, or call the Englewood location at (201) 541-6600.

About Hardik Soni, M.D. and Ethos Spa, Skin and Laser Center:

Ethos Spa, Skin and Laser Center Medical Director Hardik Soni, M.D. strives to achieve the best possible results for his patients by drawing on his experience and proficiency with multiple laser platforms, earned from having performed more than 15,000 cosmetic treatments including botulinum injection (Botox and Dysport), dermal fillers (Juvederm, Restylane, Radiesse), laser hair removal, chemical peels and laser skin rejuvenation. He is a platinum level injector with Allergan, the makers of Botox and Juvederm; his primary focus is on minimally invasive and non-invasive cosmetic procedures including Aesthera Candela, Cutera, Fraxel, Sciton and Syneron. Soni believes in a more conservative approach to cosmetic procedures, and prioritizes patient education. Clients are able to decide on their own ideal treatment after discussing their options, and weighing the expected outcomes, costs and risks.

He finished his undergraduate studies at Johns Hopkins University in Baltimore, Maryland and is board certified in Emergency Medicine. Soni currently works as an emergency room physician at Overlook Medical Center in Summit, New Jersey, as well as serving as medical director of Ethos Spa, Skin and Laser Center. He was recently chosen to the Advisory Medical Panel of Bella Magazine in NYC.

Ethos Spa, Skin and Laser Center is committed to providing the safest, most effective aesthetic procedures, customized to each individual client, utilizing the latest advances in non-invasive cosmetic treatments and technologies. Within a peaceful, luxurious environment, patients can choose from a wide array of cosmetic services and products to enhance the skins appearance.

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Ethos Spa Skin and Laser Center Adds Fractional Lens Array for PicoSure Laser for Fine Line and Sun Spot Removal ...

Lung Institutes Medical Director Celebrates 55th Anniversary in Medical Practice

Tampa, FL (PRWEB) July 29, 2014

This month marks a milestone for the Lung Institutes Medical Director, Dr. Burton Feinerman, as he celebrates his 55th anniversary in the medical field. Practicing medicine for over half a century, Dr. Feinerman has distinguished himself as a world-renowned physician in the field of regenerative medicine with the development of innovative stem cell treatments for lung diseases like chronic obstructive pulmonary disease (COPD).

Dr. Feinermans medical career has been punctuated by many firsts. In the 1950s and 1960s, Dr. Feinerman was the owner of Opa-Locka General Hospital, the only private hospital accepting African Americans in Miami, Florida. He also set up the first Pediatric Emergency Rooms in South Florida at Parkway Hospital and Miami General Hospital.

The Lung Institutes medical director was also involved with the first successful allogeneic (genetically dissimilar) bone marrow transplant performed on a 10-month-old child with severe combined/immunodeficiency, known as bubble baby. This patient, who was given a very poor prognosis of life expectancy, is now 36-years-old and a high school teacher. In 1998, Dr. Feinerman set up the first medical service website site, Webmedicalservices.com, to directly answer patient questions, which later became a public company.

It was during his time in Hawaii as the first physician to offer cosmetic dermatology and anti-aging medicine that Dr. Feinerman initially became interested in stem cells. Over subsequent years, he developed stem cell patents for a variety of disorders including Amyotrophic Lateral Sclerosis (ALS), Parkinsons, Alzheimers, multiple sclerosis, autism, cerebral palsy, COPD, pulmonary fibrosis, diabetes types 1 and 2, end-stage kidney disease and brain damage in children and adults. He also developed patents for gene therapies to treat such conditions as Tay-Sachs, Sandhoff disease, Huntingtons disease and metachromatic leukodystrophy.

Dr. Feinermans stem cell quest continues at Regenerative Medicine Solutions and Lung Institute, with his current research aimed at conquering neurological and chronic lung diseases as well as diseases causing blindness such as age-related macular degeneration, retinitis pigmentosa, and stargardts disease.

I am humbled at the acknowledgement of my role as a catalyst for change in medicine, confessed Dr. Feinerman who was honored last year as Lifetime Achievement Award finalist for the Tampa Bay Business Journals Healthcare Heroes. When I reflect back on my medical career, I only see my patients.

About the Lung Institute At the Lung Institute, we are changing the lives of hundreds of people across the nation through the innovative technology of regenerative medicine. We are committed to providing patients a more effective way to address pulmonary conditions and improve quality of life. Our physicians, through their designated practices, have gained worldwide recognition for the successful application of revolutionary minimally invasive stem cell therapies. With over a century of combined medical experience, our doctors have established a patient experience designed with the highest concern for patient safety and quality of care. For more information, visit our website at LungInstitute.com, like us on Facebook, follow us on Twitter or call us today at (855) 469-5864.

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Lung Institutes Medical Director Celebrates 55th Anniversary in Medical Practice

Pope Francis visits Caserta, has private meeting with Evangelical community

Pope Francis made a short visit to the the city of Casterta on Saturday. During his stay he had a meeting with the diocesan priests and celebrated an open air Mass. On Monday he returned to the city for a private visit with the Evangelical community, and an old friend from his days as Archbishop of Buenos Aires,Pastor Giovanni Traettino.

During his meeting with the priests on Saturday, Pope Francis set aside aside his prepared text he spoke off the cuff, answering four questions they presented to him.The Holy Father said bishops must set an example of the unity that Jesus asked of His Father for the Church. This cannot be done speaking badly about each other. The unity of bishops is important to the unity of the Church, he said, adding that the devil revels in and profits from internal conflict. The bishops must be in agreement in unity, but not in uniformity. Each one has his charism, each one has his way of thinking and his point of view; this is at times the result of mistakes, but it is often the result of the Spirit a unity in diversity, in which no-one loses his own personality.

The Pope was asked for suggestions for pastoral outreach that relaunches the primacy of the Gospel without diminishing popular piety. He answered that true popular piety was born of that Sensus Fidei described in the Encyclical Lumen Gentium and which is guided by devotion to the Saints, to the Virgin, and also by folkloric expressions, in the positive sense of the word. He added, the agnosticism that has entered into the Church in groups of intimist piety are not good, but are instead a form of heresy. Popular piety is inculturated, it cannot be produced in a laboratory, aseptic it is always born of life.

Another question focused on the identity of the priest in the third millennium. How can we overcome the existential crisis born of the linguistic, semantic and cultural revolution in evangelical witness?. With creativity, replied the Pope. It is the commandment that God gave to Adam and Jesus to his disciples. And creativity is found in prayer. A bishop who does not pray, a priest who does not pray, has closed the door to creativity.

The fourth question related to the foundations of spirituality for a priest. Francis described the priest's dual capacity for contemplation: towards God and towards man. He is a man who looks, who fills his eyes and heart with contemplation: with the Gospel before God, and with human problems when among men. The priest must be contemplative in this way. But this must not be confused with monastic life, which is something else.

Pope Francis emphasised that diocesan life must be at the centre of the spirituality of the diocesan priest. Maintaining a relationship with the bishop and with the rest of the priests simple, but at the same time not easy. The greatest enemy of these relationships is gossip. The devil knows that this seed bears fruit, and he sows it well ... to impede that evangelical, spiritual and fruitful relationship between the bishop and the presbytery. He remarked that it was better to say things clearly and openly, rather than give satisfaction to the devil who in this way attacks the centre of the spirituality of the diocesan clergy. The Holy Father concluded with some comments on the bitterness of some priests and the image of an angry Church. One may anger at times; it is healthy to be angry at times. But the state of rage is not God's, and leads only to sadness and disunity.

More than two hundred thousand people attended the Mass celebrated by the Holy Father in the square in front of the Royal Palace of Caserta on Saturday evening.

The Pope spoke in his homily about the kingdom of Heaven, based on the parables of the hidden treasure and the pearl. In the first, the kingdom is similar the treasure hidden in a field, that the farmer finds and hides again, full of joy, then sells everything he has to buy the field. In the second, a merchant who seeks fine pearls encounters one of great value and sells everything he owns in order to buy it.

The farmer and the merchant, explains the Pope, have the same sentiment in common: the surprise and joy of the fulfilment of their desires and, through these two parables, with simple words that everyone can understand, Jesus explains what the kingdom of heaven is, how it is found and what one can do to obtain it.

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Pope Francis visits Caserta, has private meeting with Evangelical community

DBT guidelines questioned on toxicity studies for Bt brinjal

Even as the Genetic Engineering Appraisal Committee (GEAC) decided to constitute a sub-committee to review the toxicology data generated by two applicants for genetically modified brinjal, biologist Dr. Pushpa M. Bhargava has questioned the guidelines of the Department of Biotechnology (DBT) on transgenic crops.

Dr. Bhargava and others had asked for the raw data on toxicity studies on rats using transgenic brinjal, which were carried out by Dr. Sesikeran, former director of National Institute of Nutrition at Hyderabad.

He found statistically quite significant differences between rats fed on Bt Brinjal and those fed on a normal meal in respect of several important parameters, said Dr. Bhargava.

However, Dr. Sesikeran had said that as all the values (both of the control and of the experimental animals) fell within the normal range of variation, the differences were not significant, and that there was no need to repeat the experiment.

Our point was that if on repetition the same differences are found again, they are bound to be significant, Dr. Bhargava pointed out. Further, he used only 20 animals (10 female and 10 male) in both experimental and the control groups, which is the minimum number for such tests. Dr. Sesikeran must explain why only a minimum number was used, he said.

In a letter to Dr. Ranjini Warrier, member-secretary, GEAC, on July 23, Dr. Bhargava, who was responding to the two emails of July 20 from Dr. Sesikaran to all the members of GEAC, said, According to Dr. Sesikeran, DBT guidelines of 2008 say the following in regard to Interpretation of results of safety studies: The design and analysis of the study should be kept as simple as possible, avoiding unnecessarily complex, sophisticated statistical techniques. If the design is simple, the statistics are likely to give straightforward results. Non-statistical knowledge must be applied in study design and proper interpretation of the biological significance of the results. Just because two treatments are statistically significantly different does not mean that the difference is large enough to have any biological importance or any practical significance.

Dr. Bhargava said he would like to know which international body endorsed this as scientifically; it does not make any sense. In fact, every sentence in this statement is flawed. For example, what is meant by the statement, If the design is simple, the statistics are likely to give straight forward results. Then, what is Non-statistical knowledge that must be applied in study design and proper interpretation of the biological significance of the results.

Further, the last sentence is biased and misleading, he said.

Surely, if the same statistically significant difference between the control and the experimental group in regard to a particular parameter is observed in repeated experiments, it is bound to have biological importance irrespective of the values falling or not falling between the normal range of variation. This can be verified by referring to any independent biology-oriented statistician of stature in India or abroad, Dr. Bhargava pointed out.

He asked the GEAC to respond to some questions he has raised in the next meeting.

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DBT guidelines questioned on toxicity studies for Bt brinjal

Skinspirations Study Supports Medical Findings: Stem Cell Treatment Triggers Tissue Regeneration

Tampa Bay, FL (PRWEB) July 28, 2014

Nearly 53 million Americans today are suffering with arthritis, with the majority of them diagnosed with osteoarthritis. (1) Osteoarthritis is a degeneration of joint cartilage and its underlying bone, causing significant pain and stiffness. While osteoarthritis has no cure, stem cell therapy has been demonstrated to induce profound healing in many forms of arthritis, according to the Stem Cell Institute. (2) Dr. Cynthia Elliott of Skinspirations, a center for cosmetic enhancement devoted to non-surgical aesthetics and now also specializing in administering regenerative medicine by stem cell, has made use of these services in a recent case study, which resulted in improved health in one of their clients.

Stem cells are unique from other cells for the following reasons:

(a)They can renew themselves through cell division; and (b)Under certain conditions, they can become tissue or organ-specific cells.

Stem cells are revered for their ability to make replacement tissues, as it relates to regenerative therapy. (3) Medical scientists and researchers are discovering the seemingly endless possibilities of what stem cells can treat, including brain damage, bone repair, kidney disease, etc. (4) This treatment is starting to boom in the medical world as a viable procedure, but Skinspirations has already had these practices in place, establishing them as progressive practitioners in the field.

Skinspirations is specifically studying the Stromal Vascular Fraction (SVF)another term for stem cell treatmentand how it affects knees with severe arthritis. According to Dr. Elliott, Stromal Vascular Fraction can help to repair, replace and restore any damaged cells within the bodyDr. Elliott performed the stem cell procedure on her uncle after first treating other patients during her training, and he experienced the following results:

Case in Point:

Joe Elliott, a 63-year-old male, had severe arthritis in one knee. Doctors advised him to get a knee replacement, but Joe was hoping to avoid surgery for as long as possible. After talking to Dr. Elliott about the treatment, he drove to Skinspirations from Missouri to go forward with the stem cell procedure.

Dr. Elliott performed the treatment with the following steps:

(1)Numbed his abdomen with anesthesia; (2)Removed about 100 cc of fat; (3)Processed the fat to isolate the SVF; (4)Numbed the arthritic knee; and (5)Injected the pellet of SVF into the joint of his arthritic knee.

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Skinspirations Study Supports Medical Findings: Stem Cell Treatment Triggers Tissue Regeneration