Select Page ::

Life Longevity and the pursuit of harmony – WKBW-TV

Posted on November 21, 2020 by Prof Baldwin

Longevity expert Dr. Brian Kennedy explains the signs behind increasing your life span and happiness. Dr. Kennedy says the United States ranks 39th in life expectancy. Sleep is key to longevity and also human connection. He says he believes the pandemic is leading to poorer lifestyle choices that are increasing our aging at the same time. Stress is affecting our sleep and its keeping us from being with our friends and family. He says weve known in the elderly these two factors are predictors for mortality. Older people often live alone and they have these problems naturally but the pandemic is really exasperating those problems for the elderly and it is extending to everyone now so we need strategies to deal with that. Dr. Kennedy says the first thing he would say sounds obvious but try to stay positive. This pandemic will come to an end. One thing that is important is mindfulness; finding ways to be self-aware to figure out whats going on in your own brain. To realize when you are stressed is a big step toward dealing with it and that can be through meditation or yoga. There isnt one right answer. Dr. Kennedy says he does a lot of runs and that clears his head. He says one thing that may be worth reading is Be Your Own Harmonist by Lola Till. He says the reason he brings it up is that it is a personal journey for a healthy lifestyle. She is not a doctor. She wanted to find a way to adopt a healthier approach to her life.

Dr. Kennedy says we are losing exercise right now if you are not going to work or out with your friends. He says probably missing four or five thousand steps a day that you normally get so it is important to find safe ways to get that exercise whether it is running or biking or exercising at home. Then with diet he says in the United States the problem is people are overeating. He said life expectancy is not going up in part because of obesity. The research shows that fasting can be very beneficial. This is going periods of time without eating. One way people do it is by time restricted eating where you eat all of your food in an 8 or 12 hour window. There are a lot of different ways to do fasting but all of them show really good benefits. They are good for metabolism, they help you lose weight, they are good for inflammation and in the long term they help rejuvenate your skin cells and deal with cellular damage. One way to do that is with a fasting mimicking diet. ProLon has this diet that has five days of food and it gives you healthy nutrition and good things to eat but keeps those pathways that drive aging and inflammation down and it gives you the benefits of fasting without actually having to go through the fast. He says he thinks a really good way to kickstart a healthy diet if you want to go down that path.

For more information click here.

For information on the book Be Your Own Harmonist by Lola Till click here.

Read the original here:
Life Longevity and the pursuit of harmony - WKBW-TV

Vaccines against COVID-19 will have side effects that’s a good thing – Kiowa County Press

Posted on December 5, 2020 by Prof Baldwin

A little bit of post-injection soreness is completely normal. Jose Luis Pelaez Inc/DigitalVision via Getty Images

Matthew Woodruff, Emory University

Takeaways

Temporary side effects from vaccines are a normal sign of a developing immune response.

Vaccines work by training your immune system to recognize and remember a pathogen in a safe way.

Expected side effects from a COVID-19 vaccine include redness and swelling at the injection site and stiffness and soreness in the muscle.

A potent vaccine may even cause fever. It does not mean that the vaccine gave you COVID-19.

In 2021 hundreds of millions of people will be vaccinated against SARS-CoV-2. The success of that COVID-19 vaccination campaign will heavily depend on public trust that the vaccines are not only effective, but also safe. To build that trust, the medical and scientific communities have a responsibility to engage in difficult discussions with the public about the significant fraction of people who will experience temporary side effects from these vaccines.

I am an immunologist who studies the fundamentals of immune responses to vaccination, so part of that responsibility falls on me.

Simply put, receiving these vaccines will likely make a whole lot of people feel crappy for a few days. That's probably a good thing, and it's a far better prospect than long-term illness or death.

In 1989, immunologist Charles Janeway published an article summarizing the state of the field of immunology. Until that point, immunologists had accepted that immune responses were initiated when encountering something foreign - bacteria, viruses, and parasites - that was "non-self."

Janeway suspected that there was more to the story, and famously laid out what he referred to as "the immunologist's dirty little secret": Your immune system doesn't just respond just to foreign things. It responds to foreign things that it perceives to be dangerous.

Now, 30 years later, immunologists know that your immune system uses a complex set of sensors to understand not only whether or not something is foreign, but also what kind of threat, if any, a microbe might pose. It can tell the difference between viruses - like SARS-CoV-2 - and parasites, like tapeworms, and activate specialized arms of your immune system to deal with those specific threats accordingly. It can even monitor the level of tissue damage caused by an invader, and ramp up your immune response to match.

Sensing the type of threat posed by a microbe, and the level of intensity of that threat, allows your immune system to select the right set of responses, wield them precisely, and avoid the very real danger of immune overreaction.

Vaccines work by introducing a safe version of a pathogen to a patient's immune system. Your immune system remembers its past encounters and responds more efficiently if it sees the same pathogen again. However, it generates memory only if the vaccine packs enough danger signals to kick off a solid immune response.

As a result, your immune system's need to sense danger before responding is at once extremely important (imagine if it started attacking the thousands of species of friendly bacteria in your gut!) and highly problematic. The requirement for danger means that your immune system is programmed not to respond unless a clear threat is identified. It also means that if I'm developing a vaccine, I have to convince your immune system that the vaccine itself is a threat worth taking seriously.

This can be accomplished in a number of ways. One is to inject a weakened - what immunologists call attenuated - or even killed version of a pathogen. This approach has the benefit of looking almost identical to the "real" pathogen, triggering many of the same danger signals and often resulting in strong, long-term immunity, as is seen in polio vaccination. It can also be risky - if you haven't weakened the pathogen enough and roll out the vaccine too fast, there is a possibility of unintentionally infecting a large number of vaccine recipients. In addition to this unacceptable human cost, the resulting loss of trust in vaccines could lead to additional suffering as fewer people take other, safer vaccines.

A safer approach is to use individual components of the pathogen, harmless by themselves but capable of training your immune system to recognize the real thing. However, these pieces of the pathogen don't often contain the danger signals necessary to stimulate a strong memory response. As a result, they need to be supplemented with synthetic danger signals, which immunologists refer to as "adjuvants."

To make vaccines more effective, whole labs have been dedicated to the testing and development of new adjuvants. All are designed with the same basic purpose - to kick the immune system into action in a way that maximizes the effectiveness and longevity of the response. In doing so, we maximize the number of people that will benefit from the vaccine and the length of time those people are protected.

To do this, we take advantage of the same sensors that your immune system uses to sense damage in an active infection. That means that while they will stimulate an effective immune response, they will do so by producing temporary inflammatory effects. At a cellular level, the vaccine triggers inflammation at the injection site. Blood vessels in the area become a little more "leaky" to help recruit immune cells into the muscle tissue, causing the area to become red and swell. All of this kicks off a full-blown immune response in a lymph node somewhere nearby that will play out over the course of weeks.

In terms of symptoms, this can result in redness and swelling at the injection site, stiffness and soreness in the muscle, tenderness and swelling of the local lymph nodes and, if the vaccine is potent enough, even fever (and that associated generally crappy feeling).

This is the balance of vaccine design - maximizing protection and benefits while minimizing their uncomfortable, but necessary, side effects. That's not to say that serious side effects don't occur - they do - but they are exceedingly rare. Two of the most discussed serious side effects, anaphalaxis (a severe allergic reaction) and Guillain-Barre Syndrome (nerve damage due to inflammation), occur at a frequency of less than 1 in 500,000 doses.

Side effects are normal.

Early data suggest that the mRNA vaccines in development against SARS-CoV-2 are highly effective - upwards of 90%. That means they are capable of stimulating robust immune responses, complete with sufficient danger signaling, in greater than nine out of 10 patients. That's a high number under any circumstances, and suggests that these vaccines are potent.

So let's be clear here. You should expect to feel sore at the injection site the day after you get vaccinated. You should expect some redness and swelling, and you might even expect to feel generally run down for a day or two post-vaccination. All of these things are normal, anticipated and even intended.

While the data aren't finalized, more than 2% of the Moderna vaccine recipients experienced what they categorized as severe temporary side effects such as fatigue and headache. The percentage of people who experience any side effects will be higher. These are signs that the vaccine is doing what it was designed to do - train your immune system to respond against something it might otherwise ignore so that you'll be protected later. It does not mean that the vaccine gave you COVID-19.

[Deep knowledge, daily. Sign up for The Conversation's newsletter.]

It all comes down to this: Some time in the coming months, you will be given a simple choice to protect yourself, your loved ones and your community from a highly transmissible and deadly disease that results in long-term health consequences for a significant number of otherwise healthy people. It may cost you a few days of feeling sick.

Please choose wisely.

Matthew Woodruff, Instructor, Lowance Center for Human Immunology, Emory University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Link:
Vaccines against COVID-19 will have side effects that's a good thing - Kiowa County Press

20 Years of Observing Earth From the Space Station An Extraordinary View From Outer Space – SciTechDaily

Posted on November 21, 2020 by Prof Baldwin

The International Space Station has been continuously occupied for two decades, and the astronauts and cosmonauts aboard have taken more than 3.5 million photographs of our home planet from space. Credit: NASA

After 20 years of continuous human presence, the International Space Station (ISS) has provided 241 visitors with an extraordinary view of Earth from outer space one they have shared with the rest of the world.

Astronaut photography, formally called Crew Earth Observations (CEO), has resulted in more than 3.5 million photographs of the ever-changing blue planet. But camera-wielding astronauts are not the only ones looking down at Earth from their perch in the sky. An impressive suite of Earth Science instruments have also visited the station to capture vast amounts of data about our planet.

However, space aboard the station itself is limited, and the spots are highly coveted. Instruments go through a rigorous approval process and cycle through every couple of years, turning the station into a virtual swiss-army knife of interchangeable remote sensing tools. An especially comprehensive suite of Earth observing instruments are currently aboard the station, with two more approved and several more proposing to become future ISS instruments.

These instruments complement one another to provide a more complete picture of Earth systems, according to William Stefanov, branch chief for the Exploration Science Office at NASAs Johnson Space Center, and principal investigator for the Crew Earth Observations Facility on the International Space Station. Thats why its serendipitously great that all of these instruments are on the International Space Station and functioning simultaneously, Stefanov said.

The ECOsystem Spaceborne Thermal Radiometer Experiment on Space Station (ECOSTRESS) is located on the Japanese Experiment Module on the International Space Station. Credit: NASA

ECOSTRESS

The human crew came in especially handy for the Ecosystem Spaceborne Thermal Radiometer Experiment on Space Station (ECOSTRESS) instrument, which records the temperature of plants on Earths surface by measuring the heat they give off. The instrument required the addition of Wi-Fi modules to transmit its data to the station, which in turn required astronauts to conduct a spacewalk to install them.

Since then, ECOSTRESS has provided new insights into the relationship between plant temperatures and water usage. It can identify plant stress down to an individual farmers field, when intervention and water management may still be possible to save crops.

Principal investigator Simon Hook says scientists have only just begun to scratch the surface of how the instrument can be used based on its frequent and high-resolution temperature measurements. There is work underway to use the temperature data to observe wildfires, droughts, volcanoes, and heat waves, or even to identify heat patterns within urban cities.

GEDI

From fields to forests, another plant-focused instrument is the Global Ecosystem Dynamics Investigation(GEDI). Using lidara method of bouncing a laser off the planet and measuring how long it takes the signal to returnGEDI is creating a record of the three-dimensional structure worlds tropical and temperate forests so that Earths tree canopies can be mapped and tracked over time.

The vertical structure of forests, which is essentially the height of the trees and how their leaves and branches are arranged vertically, can help determine how much carbon storage is lost from deforestation or gained from growing forests. GEDI principal investigator Ralph Dubayah, professor of Geographical Sciences at the University of Maryland, College Park, says this is the biggest uncertainty we have about the global carbon cycle, and why there is so much attention put on understanding how deforestation and tree growth contribute to atmospheric carbon dioxide concentrations. GEDI is a collaborative effort between NASA and UMD.

Measurements from the Global Ecosystem Dynamics Investigation (GEDI) show that tree canopy peaks in the middle of the African continent what we know as the Congo Basin. Credit: University of Maryland

To supply its high-power laser, GEDI takes advantage of the massive solar panels on the station. Right now on the International Space Station we have an amazing confluence of instruments that together are able to observe ecosystem function, structure and plant composition, Dubayah said. And it was entirely made possible because we have this incredible science platform in the ISS.

LIS

Being high above the clouds also makes the station a good platform for observing the weather. NASAs Lightning Imaging Sensor (LIS) records the time, energy output and locations of lightning events around the world in the lower atmosphere. It can provide information on when storms are growing or decaying, thereby helping to improve weather forecasting models and aircraft/spacecraft safety precautions.

It complements the Geostationary Lightning Mapper (GLM) aboard the Geostationary Operational Environmental Satellite (GOES-16), which is a collaboration between NASA, the National Atmospheric and Oceanic Administration (NOAA) and industry partners, and the European Space Agencys (ESA) monitoring of thunderstorms and upper atmosphere lightning events through the Atmosphere Space Interaction Monitor (ASIM) instrument which is on the ISS.

The data from ASIM and LIS are both able to capture the impacts of dust storms, pollution, fires, and volcanic eruptions on cloud formation and electrification. This is just one example of how ESA, and other international agencies including the German Aerospace Center(DLR) andthe Japan Aerospace Exploration Agency (JAXA), are also helping advance a global understanding of our planet through ISS-instruments with Earth observations of their own.

OCO-3

Several instruments currently aboard the station are not the first of their kind. As the name might suggest, the Orbiting Carbon Observatory-3(OCO-3) is a third iteration instrument for long-term monitoring of atmospheric carbon dioxide distributions around the globe, complementing long-term ground-based observations. It provides insights into regional carbon sources and sinks and monitors changes in the carbon cycle linked to human activity.

Together with GEDI and ECOSTRESS, OCO-3 contributes to a more complete picture of terrestrial ecosystems. While its predecessor, the OCO-2 satellite, followed a polar orbit, OCO-3s path aboard the station offers a denser data set for areas with large carbon fluxes, including Earths most biologically diverse regions like the Amazon rainforest.

The orbit also allows measurements at different times of day, which especially benefits ECOSTRESS and OCO-3 as plants and their contribution to the carbon cycle fluctuate with time of day due to variations in sun, temperature and water availability.

SAGE III

Like OCO-3, the Stratospheric Aerosol and Gas Experiment (SAGE) III, is a third-generation instrument. The successive SAGE instruments have provided an ongoing record of Earths upper atmospheric water vapor, aerosol and ozone which make up the protective sunscreen layer for the planet.

The stratospheric aerosol and gas experiment (SAGE) IIIs line of sight from the international space station provides a view of the aerosols and gases present in Earths atmosphere by taking advantage of the sunlight traveling through a slice of the atmosphere. Credit: NASA

When sunlight passes through the upper atmosphere, its unique mixture of particulates and gases create the picturesque colors of spectacular sunsets and sunrises. To replicate a sunset or sunrise view from the space station, SAGE III looks at Earth from a side angle, capturing a similar view of the atmosphere on its edge as someone watching the sunset from the ground. But from its vantage point of space, SAGE III can view the entirety of these atmospheric layers according to project scientist Dave Flittner, and sees 15 sunrises and sunsets every day.

Science manager Marilee Roell says the longevity of these observations has been crucial to monitoring and maintaining the protective ozone layer in the upper atmosphere. SAGE II closely monitored the past ozone decline from common aerosols in hair sprays and fire retardants that degraded the layer, and its data informed the Montreal Protocol Treaty, which phased out the use of these damaging chemicals.

Its one of the biggest success stories of science informing policy, said Roell. And not only is this a premier science instrument, but its also on the International Space Stationa crewed platform. We are kind of getting the best of both science and getting to be a part of the human spaceflight program in a peripheral way.

TSIS-1

Additional atmospheric measurements of the sun come from the Total and Spectral Solar Irradiance Sensor(TSIS-1) which is actually made of two instruments: the Total Irradiance Monitor (TIM) and Spectral Irradiance Monitor (SIM).

TSIS-1 continues the work of NASAs Solar Radiation and Climate Experiment satellitebymeasuring the amount of sunlight that reaches Earth, and how it is distributed in wavelength.

These measurements of solar energy, along with model-based calculations of its absorption and reflection by Earths atmosphere and surface, provide insights into the suns influence on climate, the ozone layer, atmospheric circulation, and ecosystems. The data are critical inputs for modeling of Earths climate and atmospheric systems.

COMING SOON: EMIT & CLARREO-PF

There is still more to learn about Earth, and new instruments which can further contribute to our understanding like the Climate Absolute Radiance and Refractivity Observatory (CLARREO) Pathfinder and the Earth Surface Mineral Dust Source Investigation (EMIT) are already scheduled to reach the station within the next couple of years.

The CLARREO Pathfinder will measure sunlight reflected off Earth, and take direct measurements of the Sun, with unparalleled accuracy. The data can then help calibrate other sensors starting in 2021. EMIT is scheduled to launch the following year in 2022 to map dust-source regions on Earths surface and assess the impact of dust on the warming and cooling of the atmosphere.

Its been really satisfying to see the range of things we have had on the space station, said Stefanov. From imaging systems to lasers and radars, and more recently hyperspectral instruments Stefanov believes that the limit to what they can do in the future is really only limited by what scientists and engineers are able to design and the number of instrument ports available.

There will be opportunities for new sensors to go up to the station, he said. And I think it will continue to develop as a very useful remote sensing platform for Earth observations going forward.

See more here:
20 Years of Observing Earth From the Space Station An Extraordinary View From Outer Space - SciTechDaily

Now is the time for climate action – HubcitySPOKES.com

Posted on November 21, 2020 by Prof Baldwin

If we were to hold another ballot measure next week, adopting an official statement of gratitude for the END of the election, that motion might pass with broad bipartisan support.

Regardless of outcome, campaign seasons are long and tiring, and I look forward to the more-casual conversations with all those neighbors who vote differently from me. And besides, this election was hardly a clean sweep for either wing, with strong conservative control remaining in both the Supreme Court and in the U.S. Senate. Things couldnt get much more even than they will be in 2021, and that makes working together the best path forward.

President-elect Biden was not the choice of the most progressive Democrats, representing more of a centrist ideology as compared with Elizabeth Warren, Bernie Sanders or Jay Inslee. But his election means significant consideration of progressive goals, including climate action.

In a campaign stop this past September, Biden said, Hurricanes dont swerve to avoid red states or blue states. Wildfires dont skip towns that voted a certain way. The impacts of climate change dont pick and choose. Its not a partisan phenomenon, and our response should be the same. He took a chance by making a televised climate speech and running similar ads in swing states, believing that members of both parties are concerned with this crucial issue, and that gamble paid off in victory.

Fortunately, there are plenty of conservative leaders who feel the same way; in October, Sen. Lisa Murkowski (R-AK) participated in a climate policy working group. After noting that bipartisanship gives longevity to policies, she asked colleagues to work in a way that is going to get the support that you need from both Republicans and Democrats.

But its not just politicians who are looking for climate action. According to the Yale Program on Climate Change Communication, most Mississippians are worried about the human impact on our global climate and believe Congress should act on this issue. In fact, nearly three-quarters of Mississippians want stricter regulation of CO2 pollution, and over 80% want more investments in renewable energy. And judging by the record-breaking 2020 hurricane season and the millions of acres of burned lands out west, these views are certainly justified. If we are to have any chance of turning the tide on this slowly developing disaster, quick action will be needed to curb excess greenhouse gas emissions.

There are many climate policies being debated domestically and internationally, but one of the most effective would be to enact a carbon fee. If Congress were to levy a fee on fossil fuels, they could steer our country toward sustainable energy, reducing dependence on unstable foreign energy sources and slashing emissions simultaneously. The revenues generated from the carbon fees could then be rebated to American families to spend as they see fit, reducing the burden on our consumers. There even are options to waive the carbon fees for our vital agricultural producers and place a border adjustment on foreign imports in order to protect more sustainably produced American goods.

Known as the Energy Innovation and Carbon Dividend Act and the Growing Climate Solutions Act, these types of bills are supported by such diverse groups as Farm Bureau, National Farmers Union and the U.S. Chamber of Commerce. Aside from reducing climate impacts, these bills will lead to job growth, economic advantages for American agricultural production, cleaner air and a healthier work force that is less in need of government support, and a more resilient Gulf that can continue to feed us and protect us from storms.

Mississippians are ready for Sen. Wicker and other elected representatives to support this type of legislation and help move our country forward to meet this challenge while we still have the chance.

Chris Werle of Lamar County is Mississippi state coordinator for the Citizens Climate Lobby. Write him at chriswerle@cclvolunteer.org.

The known unknowns of T cell immunity to COVID-19 – Science

Posted on November 21, 2020 by Prof Baldwin

Abstract

Tremendous progress has been made in understanding the role of T cell immunity in acute and convalescent COVID-19 infection. Here we shed light on the known unknowns of pre-existing and acquired T cell responses in relation to acute and convalescent SARS-CoV-2 infection.

The broad clinical spectrum of COVID-19 indicates widespread intraindividual differences in the host immune defense against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The underlying cause of disease heterogeneity is probably multifactorial. However, a rapid early host response is likely critical to generate control of SARS-CoV-2 viremia before spread to the lower respiratory tract and onset of damaging hyperinflammation. In this regard, the literature is full of examples where functional T cell responses can provide early control of acute viral infections, including SARS-CoV and MERS-CoV (1, 2). Although multiple studies have indicated that T cells play a role in the early immune response to SARS-CoV-2 and can generate a functional memory pool, there are still multiple unanswered questions in the field (Box 1). Here, we summarize and speculate on a specific set of questions related to T cell immunity against respiratory viral infections, with a focus on COVID-19 severity, immunity, long-term consequences, and vaccination (Fig. 1).

What do acute SARS-CoV-2-specific T cell responses in the blood tell us about contemporaneous T cell responses in the lung?

Which host and viral factors regulate the strength and efficacy of the early antiviral T cell response?

Do CD4+ T cell responses to the virus predominate over CD8+ responses in the lung as well as the blood?

Do poor CD4+ TFH responses to the virus correlate with reduced longevity of antibody responses?

Is severe COVID 19 linked to an impaired development of SARS-CoV-2-specific memory T cells?

(A) Clinical and virological factors likely to be related to the development and function of antigen-specific T cell responses against SARS-CoV-2. The impact of factors including sex, age, chronic conditions affecting immune health, viral load dynamics, degree of lymphopenia, and risk of exposure to SARS-CoV-2, on the strength and efficacy of the early antiviral T cell response remains elusive. Furthermore, some individuals experience delayed viral clearance or other symptoms for an extended period (long COVID) despite viral clearance. (B) The broad clinical spectrum of acute COVID-19 includes asymptomatic, mild, severe, and fatal outcomes. Whether convalescent individuals will be protected against SARS-CoV-2 (re)infection and the longevity of this protection remain to be determined. (C) Immunological and virological factors influence generation of SARS-CoV-2-specific T cells and may influence the clinical manifestations and quality of the induced T cell response in acute and convalescent COVID-19 patients. Here, the ability of the host to generate efficient T cell responses following SARS-CoV-2 infection are likely to be dependent on the epitopes targeted, antigen abundance, involvement of resident memory T cells (TRM) at the site of infection, presence or absence of preexisting cross-reactive T cells, and host genetic factors such as HLA type and TCR repertoire. Furthermore, the level of inflammation and amount of proinflammatory cytokines are likely to be associated with T cell activation and exhaustion and subsequent T cell memory formation. (D) The potential link between vaccination outcome in relation to T cell immunity remains to be determined.

T cells are critical to generate early control and clearance of many viral infections of the respiratory system (3). Recent studies in transgenic mouse models provided evidence that T cells are also important for viral clearance and disease resolution after SARS-CoV-2 infection (4). As such, it is not surprising that T cell activation has emerged as a hallmark of acute COVID-19; probably as a consequence of an early SARS-CoV-2-specific cellular immune response (59). Although early T cell responses may play a critical role in dampening disease severity, there are also reports describing a dysregulated and unchecked T cell activation pattern in severe cases (1012). Increased T cell activation in severe cases likely reflects increased antigen levels in the respiratory system, but whether the early T cell response reaches a state of exhaustion in subjects with severe hyperinflammation remains to be determined. Furthermore, given that COVID-19 is a disease of the respiratory tract it will be important to define if early detection of T cell activation in blood correlates with tissue-specific events. For instance, will delayed detection of SARS-CoV-2-specific T cells in blood reflect the later onset of cellular immunity in the respiratory tract or are these two compartments independent of each other in relation to disease severity?

If elicitation of an early T cell response would be beneficial to dampen COVID-19 severity, what might be the underlying causes and correlates of an early versus late onset of SARS-CoV-2-specific T cell activity? Old age and male sex are both associated with increased risk of COVID-19 complications. Interestingly, females seem to mount a somewhat stronger T cell activation following SARS-CoV-2 infection (13) and disruption of T and B cell coordination has been implicated in elderly patients with severe COVID-19 (14). On the other end of the age spectrum, decreased frequencies of IFN-+CD4+ and CD25+CD4+ T cells have been described in hospitalized pediatric patients, who have shorter lengths of stay compared with their adult counterparts (15). In conjunction with age and sex, host and viral factors probably also play a role in the early immune defense and coordination of the early SARS-CoV-2-specific T cell response. For instance, SARS-CoV-2 has mechanisms to antagonize proinflammatory signals, particularly type I IFN (IFN-I) signaling (16, 17). IFN-I proteins are key inflammatory mediators to initiate antiviral defense, from which viral evasion might lead to a delayed clearance of SARS-CoV-2 (4). This is supported by the observation that inborn errors of immunity and autoantibodies that diminish IFN-I activity are more commonly detected in patients with severe COVID-19 (18, 19). Concordantly, the early expansion and differentiation of antiviral T cells are dependent on the direct action of IFN-I. Given that activated T cells from older individuals exhibit reduced responses to IFN-I, it is tempting to speculate that higher risk elderly persons experience delayed activation of SARS-CoV-2-specific T cells that may lead to reduced clearance of the virus and exacerbated COVID-19 severity. Collectively, more data are needed from mechanistic studies in animal models as well as large cohort studies on males and females in different age groups to identify beneficial and detrimental viral and host factors that have an impact on the early T cell response against SARS-CoV-2.

Generation of memory T cells can provide lifelong protection against pathogens (20). Previous studies have demonstrated that SARS-CoV- and MERS-CoV-specific T cells can be detected many years after infection (2123). Likewise, SARS-CoV-2-specific CD4+ and CD8+ T cells are distinguished in a vast majority of convalescent donors (7, 9, 21, 2427). Studies using peripheral blood have reported stronger SARS-CoV-2-specific CD4+ than CD8+ T cell responses in most subjects. However, it is well established that CD4+ T cells experience a higher propensity to recirculate between tissues and blood than CD8+ T cells. As such, whether SARS-CoV-2-specific CD4+ T cell responses also predominate in tissues, and particularly at barrier sites close to the epithelium, needs to be confirmed through studies on the upper and lower respiratory tract.

Similar to the CD4+ T cell polarized response to many other viral infections, SARS-CoV-2-specific CD4+ T cells mainly possess a Th1 or circulating T follicular helper (TFH) cell phenotype (79, 14, 28). Circulating TFH differentiation seems to be impaired in certain patients with severe COVID-19 (11, 29) and recent analysis of postmortem lymph nodes and spleen samples showed an absence of germinal centers along with a defect in Bcl6+ TFH differentiation in deceased COVID-19 patients (30). Whether these consequences are due to sampling from postmortem patients remains unknown, but further studies are needed to clarify whether TFH cell formation is impaired by SARS-CoV-2 and could have an impact on declining antibody responses in specific convalescent donors. Furthermore, more mechanistic studies are needed to understand if memory T cells can generate protective immunity to lethal challenge with SARS-CoV-2, as previously demonstrated in SARS-CoV and MERS-CoV models (1, 2), in the presence or absence of high titers of neutralizing antibodies. Likewise, longitudinal human studies will also inform us of whether functional memory T cell responses are present many years after SARS-CoV-2 infection and correlate with protection from reinfection.

Several studies have demonstrated the presence of CD4+ and to a lesser extent CD8+ T cells recognizing SARS-CoV-2 peptides in a significant proportion of unexposed individuals (7, 21, 24, 26, 31). Mapping of SARS-CoV-2 epitopes in unexposed blood donors revealed pre-existing T cell immunity, potentially induced by seasonal human coronaviruses (HCoVs) causing common colds (27, 32). This is supported by a relatively high amino acid similarity between recognized SARS-CoV-2 epitopes and seasonal HCoVs such as HCoV-OC43, -HKU1, -229E and -NL63. The presence of cross-reactive cellular immune responses in the population generates an obstacle to the use of T cell-based assays to track SARS-CoV-2 infection rates in blood donors. Given that antibodies do not result in the same degree of cross-reactivity as T cells and are consequently easier to use in clinical diagnostic settings, serology will likely be a better readout for tracing the infection rate in the society. Nevertheless, more thorough studies are needed to better understand the full spectrum of cross-reactive versus newly-induced SARS-CoV-2-specific CD4+ and CD8+ T cell responses.

A key question in the field is whether pre-existing T cell responses influence the severity of COVID-19. Pre-existing SARS-CoV-2-specific T cells are unlikely to provide sterilizing or herd immunity but may allow the host to bypass immune evasion mechanisms, for instance evasion from IFN-I, and generate early pressure on the virus. This concept is supported by studies in mice showing that airway memory CD4+ T cells recognizing a conserved SARS-CoV epitope provided protection from related CoVs (1). Similar scenarios in which pre-existing T cells may provide earlier viral clearance and thus less severe symptoms have been proposed elsewhere (33). Here, the level of conservation between antigens may have a substantial impact on whether pre-existing T cells are beneficial or detrimental for the host. On the other hand, the concept of original antigenic sin, in which earlier induced antibody or T cell responses influence the response against future viral infections, needs further evaluation (34). If pre-existing T cells are less effective in clearing viral infection upon activation but contribute to systemic and permanent increase in inflammatory signals, it might lead to increased hyperinflammation and COVID-19 severity. In a first analysis, comparing T cell responses against SARS-CoV-2 and HCoV sequences did not find any evidence of original antigenic sin (32). Again, the level of conservation of targeted epitopes is likely to impact the outcome, and further evaluation of this concept is needed. Collectively, further animal studies and human studies done before and after SARS-CoV-2 infection are needed to define the biological relevance of pre-existing T cell responses and their role as friends or foes in host defense against SARS-CoV-2.

Resident memory T cells (TRM) are a distinct memory T cell lineage. These cells reside within tissues, do not recirculate to peripheral blood, and have been defined as local sentinels mediating rapid protection from reinfection (35). In fact, a vast majority of T cells in nonlymphoid tissues, such as the respiratory tract, are considered to be TRM (36). In terms of respiratory infections, there is a growing body of literature demonstrating that TRM can provide protection against severe pulmonary disease (37, 38). Likewise, airway CD4+ T cells can generate cross-reactive immunity between human and bat coronaviruses (1), emphasizing that cross-reactive T cells in the respiratory tract can provide protection from lethal challenge with pathogenic coronaviruses. Whether cross-reactive TRM, induced by seasonal coronaviruses, can block transmission of SARS-CoV-2 from the upper respiratory tract to the lung and thereby attenuate severe COVID-19 remains unanswered. This scenario, where TRM block the spread of viral disease from upper to lower respiratory tract, has been demonstrated in influenza A infection (37) and might account for partial immunity of secondary infection with heterologous strains (39, 40). Furthermore, whether SARS-CoV-2-specific TRM are induced after COVID-19 and whether these cells will provide protection in the long term also remains unknown (41). Although certain studies in mice have suggested that TRM in the lung are short-lived (42), there is evidence that their counterparts in the upper respiratory tract persist with minimal decay (37) and for more than a year in human lung (43). Altogether, there is currently no evidence supporting the provision of sterilizing immunity by TRM, but data presented above suggest that TRM could facilitate rapid control of upper respiratory tract SARS-CoV-2 infection, replication, and spread. In this regard, further work in animal models may provide evidence for whether local immunity mediated by TRM can achieve this type of immunity.

A substantial number of COVID-19 patients experience heterogeneous symptoms that persist over a month and onward (4446). This heterogeneous phenomenon is being referred to as long COVID and affects around 10% of all COVID-19 patients (44, 45). Many symptoms can be attributed to persistent tissue damage in severe COVID-19. Nevertheless, the fact that many individuals with milder COVID-19 symptoms also experience chronic lingering symptoms, involving the cardiovascular, nervous, and respiratory systems, indicates that persistent immune activation and/or inflammation may play a role in long COVID. Multiple mechanisms are probably involved in this condition and whether T cells play any role in long COVID is unknown. The higher incidence of long COVID in females than males, similar to autoimmune diseases (47), raises the question of whether T cells orchestrate long COVID through similar mechanisms as in autoimmune or inflammatory conditions (48, 49). One hypothetical underlying mechanism behind autoimmune-related conditions after COVID-19 could be molecular mimicry, given that HCoV-specific T cells can cross-react to myelin in multiple sclerosis patients (50). Whether SARS-CoV-2-specific T cells have the ability to react against self-antigens remains to be determined. In line with a possible effect of HLA type on COVID-19 susceptibility/severity (51, 52), we believe that larger genetic studies are needed to clarify if HLA or other immune-related genes are associated with an increased risk of developing long COVID.

Based on the uncertainty of whether cross-reactive T cells or antibodies will provide protective or long-lasting immunity to COVID-19, it will become absolutely critical to administrate a safe and effective vaccine to the population to reach broad immunity and break the negative spiral of new infections. Ongoing vaccine efforts mainly target B cells to promote the induction of neutralizing antibodies (nAbs) against SARS-CoV-2 (53, 54). Although the induction of anti-spike nAbs is the key component for an effective SARS-CoV-2 vaccine, it is well-known that T cells, and in particular TFH cells, are critical to generate antibody-producing plasma cells and long-lived memory B cells. In COVID-19 patients, high nAb titers correlated with strong CD4+ T cell responses, and the lack of functional TFH cells reacting against SARS-CoV-2 was shown to be detrimental (11, 29, 30). Preliminary results from the two major mRNA vaccine trials in humans have demonstrated potent Th1 responses (55, 56). However, previous studies have reported strong TFH responses against certain mRNA vaccines (57), and future trials should therefore include other activation induced markers, such as CD40L and/or CD200, in addition to IFN- ELISPOT assays to understand if potent B-helper mechanisms are induced by the current vaccine regimens. Other outstanding questions are whether vaccine-induced TFH responses will be equally induced in all age groups and how long these responses will persist in blood and vaccination site-draining lymph nodes. A final issue to consider is whether high quantities of vaccine-induced CD8+ T cells at local sites need to be elicited by future vaccine candidates. If the initial group of vaccines in clinical trials that are primarily focused on generating an effective nAb response provide recipients with long-standing protection, it may not be necessary to invest in such efforts. However, if problems emerge in the vaccinated population with breakthrough infections, waning antibody levels after vaccination, and/or the emergence of new viral strains, it would be wise to reconsider vaccine approaches specifically designed to induce functional CD8+ TRM responses in the upper respiratory tract.

Collective efforts have greatly enhanced our scientific understanding of T cell responses against SARS-CoV-2 but many unknowns remain to be resolved. Although it is clear that T cells play a central role in generating early control and clearance of many viral infections, their role in SARS-CoV-2 infection is only starting to be revealed. Specific T cells may even have a detrimental impact on the clinical outcome and contribute to long COVID symptoms. Currently, there is a need for deeper analysis using both animal models and longitudinal follow-up studies of large patient cohorts to define the beneficial versus detrimental aspects of SARS-CoV-2-specific T cells in acute, convalescent and vaccine settings of COVID-19.

Acknowledgments: Funding. A.C.K. was supported by the Swedish Research Council, the Karolinska Institutet, and The Center for Innovative Medicine. M.B. was supported by the Swedish Research Council, the Karolinska Institutet, the Jeansson Stiftelse, the ke Wibergs Stiftelse, the Swedish Society of Medicine, the Swedish Cancer Society, the Magnus Bergvalls Stiftelse, the Lars Hiertas Stiftelse, the Swedish Physician against AIDS Foundation, the Jonas Sderquist Stiftelse, and the Clas Groschinskys Minnesfond. Author contributions: A.C.K., M.H. and M.B. contributed to writing and drafting the illustration. A.C.K. and M.B. edited the manuscript. Competing Interests. The authors declare that they have no competing interests.

Link:
The known unknowns of T cell immunity to COVID-19 - Science

Global Biohacking Market- Industry Analysis and Forecast (2020-2027) By Type, Product, Application, End User, and Region. – Bipartisan Millennial

Posted on November 2, 2020 by Prof Baldwin

Global Biohacking Marketwas valued US$ XX Bn in 2019 and is expected to reach US$ XX Bn by 2027, at a CAGR of XX % during a forecast period.

The report study has analyzed the revenue impact of the COVID-19 pandemic on the sales revenue of the market leader, market followers, and market disrupters in the report, and the same is reflected in our analysis.

Biohacking is manipulating the biology of the brain or the body itself to enhance performance. It is known as the first widespread technological step towards human augmentation and improvement.

REQUEST FOR FREE SAMPLE REPORT:https://www.maximizemarketresearch.com/request-sample/65232

Global Biohacking Market, Dynamics:

Currently, biohacking takes place outside the established structures of science and medical research. Exploring innovative trends of neuro-nutrition and biohacking in the wellness space is expected to drive the global Biohacking market. An increase in the use of radiofrequency identification (RFID) technology in medical devices, penetration of internet of things (IoT) in healthcare, fitness, and consumer electronics are some of the prominent drivers behind the growth of the global Biohacking market. The requirement for quality healthcare needs among the populace, rise in awareness of biohacking, the prevalence of chronic diseases, and demand for smart devices and drugs are expected to boost the market growth during the forecast period.

On the other hand, stringent regulations, lack of funds required for research, and expertise are expected to limit the global biohacking market during the forecast period.

Global Biohacking Market, Segment Analysis:

Biohacking claims that enhancing and optimizing human performance, which leads to longevity. Biohackers focus on longevity through everything they do to upgrade their life and lifestyle.

Smart drugs are expected to contribute a XX% share in the global biohacking market. Nootropics are cognitive enhancers, which are available in the natural or synthetic form of substances. It helps to enhance mental skills and divided into three general categories: Dietary supplements, synthetic compounds, and prescription drugs. Supplements for memory boosting are commonly taken by students during exam periods. Consumers are seeking to optimize cognitive function and follow a nutrient-dense diet to manage their stress and work on enhancing their sleep quality. The smart drugs are supplement that complements the healthcare concern related to the human being.Forensic Laboratories are expected to contribute a XX% share in the global biohacking market. The scientists and research individuals are conducted various laboratory experiments to explore new avenues in biotechnology, genetic engineering, and molecular biology. The Biohackers embark on various experiments on the body like monitoring of the heart rate or insertion of microchips to control the stress level. They have developed various products to explore the human body. Some of the remarkable products include smart drugs, microchips, magnetic fingertips, brain sensors, RFID implants, body sensors, and smart blood pressure monitor health trackers.

Currently, wearable analytic technological devices are widely available in the market. The current generation has a positive approach towards the biohacking and its devices. The tracking of the heart rate, steps, blood sugar level, and movement of the body can be analyzed through the biohacking analytics.

Global Biohacking Market, Regional Analysis:

North America region held the dominant position in 2019 and it is projected to continue its dominance in the biohacking market during the forecast period. Dominance is attributed to the presence of the strategic presence of key players in the developed countries like the US and Canada. The region has the potential to surpass a market valuation of US $ XX Mn by 2019 and is projected to maintain its top position in the global market. Besides, an introduction of the biotechnologies and existence of the synthetic biology key players are expected to boost the market growth.

The objective of the report is to present a comprehensive analysis of the Global Biohacking Market including all the stakeholders of the industry. The past and current status of the industry with forecasted market size and trends are presented in the report with the analysis of complicated data in simple language. The report covers all the aspects of the industry with a dedicated study of key players that includes market leaders, followers, and new entrants by region. PORTER, SVOR, PESTEL analysis with the potential impact of micro-economic factors by region on the market has been presented in the report. External as well as internal factors that are supposed to affect the business positively or negatively have been analyzed, which will give a clear futuristic view of the industry to the decision-makers.The report also helps in understanding Global Biohacking Market dynamics, structure by analyzing the market segments and projects the Global Biohacking Market size. Clear representation of competitive analysis of key players by Application, price, financial position, Product portfolio, growth strategies, and regional presence in the Global Biohacking Market make the report investors guide.

DO INQUIRY BEFORE PURCHASING REPORT HERE:https://www.maximizemarketresearch.com/inquiry-before-buying/65232

Scope of the Global Biohacking Market

Global Biohacking Market, By Type

Outside Biohacking Inside BiohackingGlobal Biohacking Market, By Product

Smart Drugs Sensors Strains OthersGlobal Biohacking Market, By Application

Synthetic Biology Genetic Engineering Forensic Science Diagnosis & Treatment Drug Testing OthersGlobal Biohacking Market, By End User

Pharmaceutical & Biotechnology Companies Forensic Laboratories OthersGlobal Biohacking Market, By Region

North America Europe Asia Pacific Middle East & Africa South AmericaKey players operating in Global Biohacking Market

Fitbit, Inc. Apple Synbiota The Odin HVMN, Inc. Thync Global Inc., U.S.A MoodMetric InteraXon Inc. Behavioral Tech

Browse Full Report with Facts and Figures of Biohacking Market Report at:https://www.maximizemarketresearch.com/market-report/global-biohacking-market/65232/

About Us:

Maximize Market Research provides B2B and B2C market research on 20,000 high growth emerging technologies & opportunities in Chemical, Healthcare, Pharmaceuticals, Electronics & Communications, Internet of Things, Food and Beverages, Aerospace and Defense and other manufacturing sectors.

Contact info:

Name: Vikas Godage

Organization: MAXIMIZE MARKET RESEARCH PVT. LTD.

Email: sales@maximizemarketresearch.com

Contact: +919607065656/ +919607195908

Website:www.maximizemarketresearch.com

View post:
Global Biohacking Market- Industry Analysis and Forecast (2020-2027) By Type, Product, Application, End User, and Region. - Bipartisan Millennial

Global AI Medicine Software Market Analysis of Key Players, Type, Application, Demand and Consumption By 2026 – Stock Market Vista

Posted on November 7, 2020 by Prof Baldwin

There are millions of them around the globe waiting for clutching on to some of the latest vital information circulating across the globe. The up-to-the-minute AI Medicine Software market report based on the growth and the development of theAI Medicine Software marketis systematically listed down. The AI Medicine Software market report comprises statistically verified facts such the unique essence including topological investigations, worldwide market share, government stringent norms, applications, current trends, futuristic plans, market bifurcations, and so on mentioned in a crystal clear pattern.

The statistical plus scientific AI Medicine Software market report has all the important market aspects penciled down in a layman language format so that the data based on the markets productivity or future strategy can be easily extrapolated from the reports. The AI Medicine Software market report has the dominant market players Tempus Labs, Inc., Flatiron Health, Inc., Gene42, Inc., Sunquest Information Systems Inc, 2bPrecise LLC, NantHealth, Inc, IBM Watson Group, Human Longevity, Inc., N-of-One, Inc., Translational Software, Inc, SOPHiA GENETICS SA, Syapse, Inc., LifeOmic Heal explained in detail.

Sample of global AI Medicine Software Market Report at::https://www.marketresearchstore.com/report/global-ai-medicine-software-market-report-2020-industry-761259#RequestSample

The essential futuristic segments such as {Machine Learning, Natural Language Processing, Others}; {Drug Discovery, Precision Medicine, Others} have also been detailed out in the AI Medicine Software market report for the clients convenience and more of vital data embracing capability. The forecast trends along with the current market status can better understand the AI Medicine Software market development on a global basis. The intricate industrial strategies and the supply-demand chain are also discussed in the contextual report.

Key points of the global AI Medicine Software market

Theoretical analysis of the global AI Medicine Software market stimulators, products, and other vital facets Recent, historical, and future trends in terms of revenue and market dynamics are reported Pin-point analysis of the competitive market dynamics and investment structure is predicted to grow Future market trends, latest innovations, and various business strategies are reported Market dynamics include growth influencers, opportunities, threats, challenges, and other crucial facets

The AI Medicine Software market report has the imperative data mentioned in a systematic way only after comprehensive inspection and vigilant referencing. The diagrammatic representations such as a pie chart of the AI Medicine Software market are also drawn out so as to attract the punters and make it easy for them to comprehend the entire AI Medicine Software market from in and out. The most eye-catching format of the AI Medicine Software market report is its market bifurcation based on the product type, application, geography, end-users, and more as per the particular market. The geographical segments Europe, North America, Latin America, Asia Pacific, and Middle East & Africa are further exhaustively mentioned.

Read Detailed Index of full Research Study at::https://www.marketresearchstore.com/report/global-ai-medicine-software-market-report-2020-industry-761259

Questions answered in the report include

1. What is the expected market size by the end of the forecast period?2. What are the major factors initiating the global AI Medicine Software market growth?3. What are the latest developments and trending market strategies that are influencing the growth of the AI Medicine Software market?4. What are the key outcomes of the AI Medicine Software market developments?5. Who are the key players in the market?6. What are the opportunities and challenges faced by the key players?

The AI Medicine Software market report endows the global market dominance, market segmentation, growth factors, and others reported such that the clients can have a total tour of the market without any much off efforts needed.

Key Reasons for Purchasing Global AI Medicine Software Market Report

New approaches and latest development trend that describe the structure of the market Advanced market breakdown structure Historical data and future market scope In-depth market analysis based on statistics, growth stimulators, and market developments Statistical data representation through figurative, numerical, and theoretical elaboration Report provides insight of the business and sales activities

Ask Any Kind of Query Before Purchasing the Report Here:https://www.marketresearchstore.com/report/global-ai-medicine-software-market-report-2020-industry-761259#InquiryForBuying

Originally posted here:
Global AI Medicine Software Market Analysis of Key Players, Type, Application, Demand and Consumption By 2026 - Stock Market Vista

Global AI Medicine Software Market Report 2020 by Key Players, Types, Applications, Countries, Market Size, Forecast to 2026 (Based on 2020 COVID-19…

Posted on October 28, 2020 by Prof Baldwin

The AI Medicine Software market is expected to grow from USD X.X million in 2020 to USD X.X million by 2026, at a CAGR of X.X% during the forecast period. The global AI Medicine Software market report is a comprehensive research that focuses on the overall consumption structure, development trends, sales models and sales of top countries in the global AI Medicine Software market. The report focuses on well-known providers in the global AI Medicine Software industry, market segments, competition, and the macro environment.

Under COVID-19 Outbreak, how the AI Medicine Software Industry will develop is also analyzed in detail in Chapter 1.7 of the report., In Chapter 2.4, we analyzed industry trends in the context of COVID-19., In Chapter 3.5, we analyzed the impact of COVID-19 on the product industry chain based on the upstream and downstream markets., In Chapters 6 to 10 of the report, we analyze the impact of COVID-19 on various regions and major countries., In chapter 13.5, the impact of COVID-19 on the future development of the industry is pointed out.

A holistic study of the market is made by considering a variety of factors, from demographics conditions and business cycles in a particular country to market-specific microeconomic impacts. The study found the shift in market paradigms in terms of regional competitive advantage and the competitive landscape of major players.

Download PDF Sample of AI Medicine Software Market report @ https://www.arcognizance.com/enquiry-sample/1334264

Key players in the global AI Medicine Software market covered in Chapter 4:, Tempus Labs, Inc., Flatiron Health, Inc., Gene42, Inc., Sunquest Information Systems Inc, 2bPrecise LLC, NantHealth, Inc, IBM Watson Group, Human Longevity, Inc., N-of-One, Inc., Translational Software, Inc, SOPHiA GENETICS SA, Syapse, Inc., LifeOmic Health, LLC, PierianDx, Inc, Fabric Genomics, Foundation Medicine, Inc., Koninklijke Philips N.V.

In Chapter 11 and 13.3, on the basis of types, the AI Medicine Software market from 2015 to 2026 is primarily split into:, Machine Learning, Natural Language Processing, Others

In Chapter 12 and 13.4, on the basis of applications, the AI Medicine Software market from 2015 to 2026 covers:, Drug Discovery, Precision Medicine, Others

Check Discount

Geographically, the detailed analysis of consumption, revenue, market share and growth rate, historic and forecast (2015-2026) of the following regions are covered in Chapter 5, 6, 7, 8, 9, 10, 13:, North America (Covered in Chapter 6 and 13), United States, Canada, Mexico, Europe (Covered in Chapter 7 and 13), Germany, UK, France, Italy, Spain, Russia, Others, Asia-Pacific (Covered in Chapter 8 and 13), China, Japan, South Korea, Australia, India, Southeast Asia, Others, Middle East and Africa (Covered in Chapter 9 and 13), Saudi Arabia, UAE, Egypt, Nigeria, South Africa, Others, South America (Covered in Chapter 10 and 13), Brazil, Argentina, Columbia, Chile, Others

Years considered for this report:, Historical Years: 2015-2019, Base Year: 2019, Estimated Year: 2020, Forecast Period: 2020-2026

Some Point of Table of Content:

Chapter One: Report Overview

Chapter Two: Global Market Growth Trends

Chapter Three: Value Chain of AI Medicine Software Market

Chapter Four: Players Profiles

Chapter Five: Global AI Medicine Software Market Analysis by Regions

[emailprotected] https://www.arcognizance.com/purchase/1334264

Chapter Six: North America AI Medicine Software Market Analysis by Countries

Chapter Seven: Europe AI Medicine Software Market Analysis by Countries

Chapter Eight: Asia-Pacific AI Medicine Software Market Analysis by Countries

Chapter Nine: Middle East and Africa AI Medicine Software Market Analysis by Countries

Chapter Ten: South America AI Medicine Software Market Analysis by Countries

Chapter Eleven: Global AI Medicine Software Market Segment by Types

Chapter Twelve: Global AI Medicine Software Market Segment by Applications12.1 Global AI Medicine Software Sales, Revenue and Market Share by Applications (2015-2020)12.1.1 Global AI Medicine Software Sales and Market Share by Applications (2015-2020)12.1.2 Global AI Medicine Software Revenue and Market Share by Applications (2015-2020)12.2 Drug Discovery Sales, Revenue and Growth Rate (2015-2020)12.3 Precision Medicine Sales, Revenue and Growth Rate (2015-2020)12.4 Others Sales, Revenue and Growth Rate (2015-2020)

Chapter Thirteen: AI Medicine Software Market Forecast by Regions (2020-2026) continue

List of tablesList of Tables and FiguresTable Global AI Medicine Software Market Size Growth Rate by Type (2020-2026)Figure Global AI Medicine Software Market Share by Type in 2019 & 2026Figure Machine Learning FeaturesFigure Natural Language Processing FeaturesFigure Others FeaturesTable Global AI Medicine Software Market Size Growth by Application (2020-2026)Figure Global AI Medicine Software Market Share by Application in 2019 & 2026Figure Drug Discovery DescriptionFigure Precision Medicine DescriptionFigure Others DescriptionFigure Global COVID-19 Status OverviewTable Influence of COVID-19 Outbreak on AI Medicine Software Industry DevelopmentTable SWOT AnalysisFigure Porters Five Forces AnalysisFigure Global AI Medicine Software Market Size and Growth Rate 2015-2026Table Industry NewsTable Industry PoliciesFigure Value Chain Status of AI Medicine SoftwareFigure Production Process of AI Medicine SoftwareFigure Manufacturing Cost Structure of AI Medicine SoftwareFigure Major Company Analysis (by Business Distribution Base, by Product Type)Table Downstream Major Customer Analysis (by Region)Table Tempus Labs, Inc. ProfileTable Tempus Labs, Inc. Production, Value, Price, Gross Margin 2015-2020Table Flatiron Health, Inc. ProfileTable Flatiron Health, Inc. Production, Value, Price, Gross Margin 2015-2020Table Gene42, Inc. ProfileTable Gene42, Inc. Production, Value, Price, Gross Margin 2015-2020Table Sunquest Information Systems Inc ProfileTable Sunquest Information Systems Inc Production, Value, Price, Gross Margin 2015-2020Table 2bPrecise LLC ProfileTable 2bPrecise LLC Production, Value, Price, Gross Margin 2015-2020Table NantHealth, Inc ProfileTable NantHealth, Inc Production, Value, Price, Gross Margin 2015-2020Table IBM Watson Group ProfileTable IBM Watson Group Production, Value, Price, Gross Margin 2015-2020Table Human Longevity, Inc. ProfileTable Human Longevity, Inc. Production, Value, Price, Gross Margin 2015-2020Table N-of-One, Inc. ProfileTable N-of-One, Inc. Production, Value, Price, Gross Margin 2015-2020Table Translational Software, Inc ProfileTable Translational Software, Inc Production, Value, Price, Gross Margin 2015-2020Table SOPHiA GENETICS SA ProfileTable SOPHiA GENETICS SA Production, Value, Price, Gross Margin 2015-2020Table Syapse, Inc. ProfileTable Syapse, Inc. Production, Value, Price, Gross Margin 2015-2020Table LifeOmic Health, LLC ProfileTable LifeOmic Health, LLC Production, Value, Price, Gross Margin 2015-2020Table PierianDx, Inc ProfileTable PierianDx, Inc Production, Value, Price, Gross Margin 2015-2020Table Fabric Genomics ProfileTable Fabric Genomics Production, Value, Price, Gross Margin 2015-2020Table Foundation Medicine, Inc. ProfileTable Foundation Medicine, Inc. Production, Value, Price, Gross Margin 2015-2020Table Koninklijke Philips N.V. ProfileTable Koninklijke Philips N.V. Production, Value, Price, Gross Margin 2015-2020Figure Global AI Medicine Software Sales and Growth Rate (2015-2020)Figure Global AI Medicine Software Revenue ($) and Growth (2015-2020)Table Global AI Medicine Software Sales by Regions (2015-2020)Table Global AI Medicine Software Sales Market Share by Regions (2015-2020)Table Global AI Medicine Software Revenue ($) by Regions (2015-2020)Table Global AI Medicine Software Revenue Market Share by Regions (2015-2020)Table Global AI Medicine Software Revenue Market Share by Regions in 2015Table Global AI Medicine Software Revenue Market Share by Regions in 2019Figure North America AI Medicine Software Sales and Growth Rate (2015-2020)Figure Europe AI Medicine Software Sales and Growth Rate (2015-2020)Figure Asia-Pacific AI Medicine Software Sales and Growth Rate (2015-2020)Figure Middle East and Africa AI Medicine Software Sales and Growth Rate (2015-2020)Figure South America AI Medicine Software Sales and Growth Rate (2015-2020)Figure North America AI Medicine Software Revenue ($) and Growth (2015-2020)Table North America AI Medicine Software Sales by Countries (2015-2020)Table North America AI Medicine Software Sales Market Share by Countries (2015-2020)Figure North America AI Medicine Software Sales Market Share by Countries in 2015Figure North America AI Medicine Software Sales Market Share by Countries in 2019Table North America AI Medicine Software Revenue ($) by Countries (2015-2020)Table North America AI Medicine Software Revenue Market Share by Countries (2015-2020)Figure North America AI Medicine Software Revenue Market Share by Countries in 2015Figure North America AI Medicine Software Revenue Market Share by Countries in 2019Figure United States AI Medicine Software Sales and Growth Rate (2015-2020)Figure Canada AI Medicine Software Sales and Growth Rate (2015-2020)Figure Mexico AI Medicine Software Sales and Growth (2015-2020)Figure Europe AI Medicine Software Revenue ($) Growth (2015-2020)Table Europe AI Medicine Software Sales by Countries (2015-2020)Table Europe AI Medicine Software Sales Market Share by Countries (2015-2020)Figure Europe AI Medicine Software Sales Market Share by Countries in 2015Figure Europe AI Medicine Software Sales Market Share by Countries in 2019Table Europe AI Medicine Software Revenue ($) by Countries (2015-2020)Table Europe AI Medicine Software Revenue Market Share by Countries (2015-2020)Figure Europe AI Medicine Software Revenue Market Share by Countries in 2015Figure Europe AI Medicine Software Revenue Market Share by Countries in 2019Figure Germany AI Medicine Software Sales and Growth Rate (2015-2020)Figure UK AI Medicine Software Sales and Growth Rate (2015-2020)Figure France AI Medicine Software Sales and Growth Rate (2015-2020)Figure Italy AI Medicine Software Sales and Growth Rate (2015-2020)Figure Spain AI Medicine Software Sales and Growth Rate (2015-2020)Figure Russia AI Medicine Software Sales and Growth Rate (2015-2020)Figure Asia-Pacific AI Medicine Software Revenue ($) and Growth (2015-2020)Table Asia-Pacific AI Medicine Software Sales by Countries (2015-2020)Table Asia-Pacific AI Medicine Software Sales Market Share by Countries (2015-2020)Figure Asia-Pacific AI Medicine Software Sales Market Share by Countries in 2015Figure Asia-Pacific AI Medicine Software Sales Market Share by Countries in 2019Table Asia-Pacific AI Medicine Software Revenue ($) by Countries (2015-2020)Table Asia-Pacific AI Medicine Software Revenue Market Share by Countries (2015-2020)Figure Asia-Pacific AI Medicine Software Revenue Market Share by Countries in 2015Figure Asia-Pacific AI Medicine Software Revenue Market Share by Countries in 2019Figure China AI Medicine Software Sales and Growth Rate (2015-2020)Figure Japan AI Medicine Software Sales and Growth Rate (2015-2020)Figure South Korea AI Medicine Software Sales and Growth Rate (2015-2020)Figure Australia AI Medicine Software Sales and Growth Rate (2015-2020)Figure India AI Medicine Software Sales and Growth Rate (2015-2020)Figure Southeast Asia AI Medicine Software Sales and Growth Rate (2015-2020)Figure Middle East and Africa AI Medicine Software Revenue ($) and Growth (2015-2020)continue

If you have any special requirements, please let us know and we will offer you the report as you want.

About Us:Analytical Research Cognizance (ARC)is a trusted hub for research reports that critically renders accurate and statistical data for your business growth. Our extensive database of examined market reports places us amongst the best industry report firms. Our professionally equipped team further strengthens ARCs potential.ARC works with the mission of creating a platform where marketers can have access to informative, latest and well researched reports. To achieve this aim our experts tactically scrutinize every report that comes under their eye.

Contact Us:Ranjeet DengaleDirector SalesAnalytical Research Cognizance+1 (646) 403-4695, +91 90967 44448Email: [emailprotected]

NOTE: Our report does take into account the impact of coronavirus pandemic and dedicates qualitative as well as quantitative sections of information within the report that emphasizes the impact of COVID-19.

As this pandemic is ongoing and leading to dynamic shifts in stocks and businesses worldwide, we take into account the current condition and forecast the market data taking into consideration the micro and macroeconomic factors that will be affected by the pandemic.

See original here:
Global AI Medicine Software Market Report 2020 by Key Players, Types, Applications, Countries, Market Size, Forecast to 2026 (Based on 2020 COVID-19...

Personalized Cell Therapeutic Market Overview,Top Manufactures and Strong Growth rate – PRnews Leader

Posted on November 2, 2020 by Prof Baldwin

The Personalized Cell Therapeutic Market report gives acquaintance about all the recent developments, product launches, joint ventures, mergers and acquisitions by several key players and brands while also giving a synopsis of market definition, classifications, and market trends. It lends a hand to companies to take decisive actions to deal with threats in a niche market. This market research report also provides thorough information about target markets or customers. Global Personalized Cell Therapeutic Market report is a sure-fire solution that businesses can adopt to thrive in this swiftly changing marketplace. For outstanding business growth, companies must take upmarket research report service which has become enough vital in todays market place.

Personalized cell therapeutic market is expected to gain market growth in the forecast period of 2020 to 2027. Data Bridge Market Research analyses the market is growing at a healthy CAGR in the above-mentioned research forecast period. Emerging markets and huge investments in research and development are the factors responsible for the growth of this market.

Request Free Sample PDF (including COVID19 Impact Analysis) of Personalized Cell Therapeutic Market[emailprotected] https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-personalized-cell-therapeutic-market&utm_source=&kA

The research study includes the latest updates about the COVID-19 impact on the Personalized Cell Therapeutic sector. The outbreak has broadly influenced the global economic landscape. The report contains a complete breakdown of the current situation in the ever-evolving business sector and estimates the aftereffects of the outbreak on the overall economy.

The Global Personalized Cell Therapeutic Market research report assembles data collected from different regulatory organizations to assess the growth of the segments. In addition, the study also appraises the global Personalized Cell Therapeutic market on the basis of topography. It reviews the macro- and microeconomic features influencing the growth of the Personalized Cell Therapeutic Market in each region. Various organizational tools are used to analyze the growth of the worldwide Personalized Cell Therapeutic market.

In-depth qualitative analyses includeSympathyand investigation of the following aspects:

Prominent Key Players Covered in the report:

Personalized Stem Cells, Cytori Therapeutics Inc., Bellicum Pharmaceuticals, Inc., Saneron CCEL Therapeutics, Inc., MolMed S.p.A., Vericel Corporation, Novartis AG, Gilead Sciences, Inc., Celgene Corporation, Bluebird Bio, Inc., Osiris Therapeutics Inc., Human Longevity Inc., and Aurora Biopharma Inc.

Regions Covered in the Global Personalized Cell Therapeutic Market:

North America

Europe

Asia-Pacific

South America

Middle East and Africa

Get Table Of Contents of This Premium Research For Free: https://www.databridgemarketresearch.com/toc/?dbmr=global-personalized-cell-therapeutic-market&utm_source=&KA

How Does This Market Insights Help?

Report Content Overview:

Reasons to Purchase this Report

Get Sample Copy (Including FULL TOC, Graphs and Tables) of this report @https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-personalized-cell-therapeutic-market&utm_source=&kA

TABLE OF CONTENTS

Part 01:Executive Summary

Part 02:Scope of the Report

Part 03:Research Methodology

Part 04:Market Landscape

Part 05:Pipeline Analysis

Pipeline Analysis

Part 06:Market Sizing

Market Definition

Market Sizing

Market Size And Forecast

Part 07:Five Forces Analysis

Bargaining Power Of Buyers

Bargaining Power Of Suppliers

Threat Of New Entrants

Threat Of Substitutes

Threat Of Rivalry

Market Condition

Part 08:Market Segmentation

Segmentation

Comparison

Market Opportunity

Part 09:Customer Landscape

Part 10:Regional Landscape

Part 11:Decision Framework

Part 12:Drivers and Challenges

Market Drivers

Market Challenges

Part 13:Market Trends

Part 14:Vendor Landscape

Part 15:Vendor Analysis

Vendors Covered

Vendor Classification

Market Positioning Of Vendors

Part 16:Appendix

Personalized Cell Therapeutic Marketwill prove as a valuable source of guidance for professional clients like Tier 1, Tier 2, Tier 3 level managers, CEOs, CMOs, as well as interested individual readers across the world. Vendor Landscape provide acts as key development and focus of above professional with common aim to lead the way of Personalized Cell Therapeutic Market Worldwide.

In conclusion, the Personalized Cell Therapeutic Market report is a reliable source for accessing the research data that is projected to exponentially accelerate your business. The report provides information such as economic scenarios, benefits, limits, trends, market growth rates, and figures. SWOT analysis is also incorporated in the report along with speculation attainability investigation and venture return investigation.

Get Enquiry About This Comprehensive [emailprotected]https://www.databridgemarketresearch.com/inquire-before-buying/?dbmr=global-personalized-cell-therapeutic-market&utm_source=&KA

Thank you for reading this article. You can also get chapter-wise sections or region-wise report coverage for North America, Europe, Asia Pacific, Latin America, and Middle East & Africa.

If you have any query or customizationPersonalized Cell TherapeuticMarket Report:

If you wish to find more details of the report or want customization, contact us at[emailprotected]. You can get a detailed of the entire research here. If you have any special requirements, please let us know and we will offer you the report as you want.

Contact:

US: +1 888 387 2818

UK: +44 208 089 1725

Hong Kong: +852 8192 7475

[emailprotected]

Read this article:
Personalized Cell Therapeutic Market Overview,Top Manufactures and Strong Growth rate - PRnews Leader

‘Aging in Your 20s and 30s’ panel to be held Oct. 16 – College of Health and Human Sciences – Source

Posted on October 6, 2020 by Prof Baldwin

The Columbine Health Systems Center for Healthy Aging is hosting a virtual panel discussion at noon on Friday, Oct. 16, to answer community questions about how young people can live longer, healthier lives.

One of the Centers new initiatives is to encourage people in their 20s and 30s to think about what they can do now to support longevity and health across their lifespan and into advanced age, says Nicole Ehrhart, director of the Center and professor in the Department of Clinical Sciences. Research shows that people in their second and third decades rarely explore these topics.

As such, the premise of the panel is to cut through the noise and abundance of health and wellness tips to provide clear recommendations for healthy aging in young adults.

CSU faculty members from the College of Health and Human Sciences will serve as panelists for the discussion, including:

All questions surrounding diet, nutrition, fitness, mental health and general well-being are welcome. Questions can be submitted by emailing healthyaging@colostate.edu. Some to be answered by the panelists include:

Thus, while the panel is geared toward younger people, it will provide general health advice that people of all ages can benefit from.

Attendees may register in advance for the webinar at col.st/pAe2s

The webinar will be recorded for later viewing on the Center for Healthy Agings YouTube playlist.

The rest is here:
'Aging in Your 20s and 30s' panel to be held Oct. 16 - College of Health and Human Sciences - Source

A Vaccine That Protects Against COVID-19 May Be Right Under Our Noses : Shots – Health News – NPR

Posted on October 8, 2020 by Prof Baldwin

The nasal spray version of the flu vaccine contains live but weakened form of the virus. Researchers think there's a good chance this could help boost the body's immunity and improve its ability to fight off pathogens such as the coronavirus. Tim Sloan/AFP via Getty Images hide caption

In case you were still procrastinating getting a flu shot this year, here's another reason to make it a priority.

There's a chance the vaccine could offer some protection against COVID-19 itself, says virologist Robert Gallo, who directs the Institute of Human Virology at the University of Maryland School of Medicine and is chairman of the Global Virus Network.

The key is getting the right flu vaccine, says Gallo, who was one of the main scientists credited with discovering HIV. "The vaccine has to have a live virus in it. The virus is attenuated so it doesn't cause disease, but otherwise the virus is alive."

A live virus may sound a bit terrifying, but it's a standard way to make safe and effective vaccines. In fact, you've probably already had a few "live, attenuated" vaccines in your lifetime, such as the measles vaccine or oral polio vaccine.

Now scientists are just beginning to learn that these vaccines may offer some unexpected advantages to the immune system.

When developing a vaccine, scientists have a few strategies to try. They can take a piece or component of the bacteria and use that to trigger an immune response in a person. They can kill the pathogen and use its corpse as the vaccine. Or they can take a live pathogen and weaken it in the lab.

The latter are called "live, attenuated vaccines," and over the past century, scientists have noticed something peculiar about these vaccines: They seem to offer some protection, not just from the targeted disease, but also against many different diseases, including respiratory infections.

"There's plenty of evidence for it," Gallo says. "The weakness is we don't really know the longevity [of the protection]. It will probably work only for months, but we can't say for sure."

Take for instance, the vaccine for tuberculosis. It's called bacille Calmette-Guerin, or BCG, and it contains a live, but weakened, strain of TB from cows.

When doctors in Sweden first started using BCG back in the 1920s, they noticed not only that the vaccine reduced a child's risk from dying of TB, but also that children who got it had a mortality rate from all causes that was almost three times lower than unvaccinated children. Since the 1970s, scientists in West Africa have documented a similar pattern with both the BCG vaccine and the live measles vaccine. In other words, the vaccines were doing something to boost the immune system's response to many kinds of pathogens.

Recently, doctors in the Netherlands directly tested the BCG vaccine against a placebo, to see if it could help volunteers fight off a weakened form of yellow fever. The conclusion? People who received the BCG vaccine mounted a stronger immune response against the virus and cleared out the virus more effectively than those who received the placebo, the study reported.

It's not just BCG that seems to have this effect. There's growing evidence that any live vaccines can offer some broad, nonspecific protection, including the oral polio vaccine, measles and the live flu vaccine.

Scientists have had a hard time believing the evidence because the idea goes against the way they thought vaccines work, says immunologist Zhou Xing at McMasters University in Ontario. "It's a new concept that has emerged in the field of immunology over the past five to 10 years or so."

In general, vaccines work by tricking the body to produce antibodies. These molecules are very specific. They typically target and neutralize only one type of infection.

Live vaccines also work through antibodies, but they likely do something else, as well. They supercharge our body's front-line defenders the cells that first recognize an invader and try to clear it out before the infection gets out of control, Zhou says. Specifically, scientists think live vaccines epigenetically reprogram immune cells in the bone marrow, called myeloid cells.

Unlike antibodies, myeloid cells are nonspecific they work on many types of invaders. And they work quickly when the virus first enters a person's body.

Now the big question is: Will live vaccines help a person clear out the coronavirus from their body before they get sick or before the infection becomes severe?

To figure that out, scientists around the world are currently running more than a dozen clinical trials with both BCG and the live polio vaccine to see whether they offer some protection against the virus that causes COVID-19.

No one believes the protection will be as strong or as long-lived as that provided by a specific COVID-19 vaccine, says Dr. Moshe Arditi, who leads one of the trials at Cedars Sinai in Los Angeles.

But, he says, the BCG vaccine has several advantages to a specific vaccine. It's cheap. A dose only costs a few dollars. And we already know it's safe. "More than 130 million kids every year every year receive the BCG vaccine so the safety profile has been very strong," Arditi says.

So the BCG vaccine could be approved and available by early next year, he says. "It could be a bridge until we have a safe, effective COVID-19 vaccine."

In the meantime, virologist Robert Gallo says, why not go get the live flu vaccine, if you can?

This year, the flu vaccine comes in two major forms: a shot or a nasal spray. The shot, which is approved for all people above age 6 months who don't have contraindications, contains an inactivated virus or components of the virus. The nasal spray (FluMist), which is approved for people ages 2 to 49, contains live, attenuated flu viruses.

"You watch," Gallo says. "People who get the live flu vaccine will also be protected against the COVID-19. That's the hypothesis."

However, even if you get a vaccine, you should still exercise all the same cautious you would otherwise: Wear a mask, keep your distance, wash your hands and avoid large indoor gatherings.

Read the original here:
A Vaccine That Protects Against COVID-19 May Be Right Under Our Noses : Shots - Health News - NPR

3 Steps to Building the Workplace Culture You Want – The Advocate

Posted on October 4, 2020 by Prof Baldwin

Photo: Luis Alvarez | Getty Images

3 Steps to Building the Workplace Culture You Want

Every business leader influences their employees, but that influence should proceed with intentionand a clear understanding of the desired end state of their workplaceculture and its relationship tocompany objectives. A leader moving without a clear, consistent focus can very quickly erode confidence and lead to toxic impacts that can be difficult to reverse and impact the companys financial bottom line. Leaders of small businesses, in particular, should realize the direct line betweenleader-employee functioning and company stability.

Becoming an effective influencer as a leader is not a simple task. If it was, there would be a smaller percentage of disgruntled ex-employees and broad-based reduction in workforce turnover. A commonly referenced fact in human resources is that a majority of employees leave their employers due to management and failures to lead. From personal experience, having supported many entrepreneurs of large and small organizations over the last 20 years, a sampling of common, consistent reasons for employees departing shared with me include:

Related:6 Entrepreneurs Share Secrets for Boosting Office Morale

Here are some approaches toward building a workplace devoid of these beliefs, with committed employees.

A common desire shared to me from business owners experiencing growth is that their next employee be a unicorn that elusive individual with the innate qualities that are hard to cultivate and can lead to evolution of the organization at large. My response when hearing this is, What plans do you have to develop your current workforce into that ideal? The answers are commonly inconclusive.

Most companies have not invested in training programs that provide effective means for evolvingtheir workforce towards its highest potential state. Such investments, when made effectively, have the benefit of not only improving workforce success in people individual roles, but lead to improved satisfaction, long-term workforce stabilityand improved confidence by leadership being in their corner.

A few critical, but often overlooked, training areas that I recommend companies incorporate include:

At some point, nearly every company will arrive at the decision to document its shared beliefs as value statements. When Iwork with a new organization to identityareas of improvement,senior leadership will inevitably share their corporate values as a precursor introduction to their culture and guiding principles. In a vast majority of cases, I receive feedback that indicates employees mostly experience those as somewhat akin to buzzwords affirmed infrequently (and generally for public benefit), and mostly absent from daily decisions.

This importance of a focus on daily application of values cannot be overstated. It is foundational to belief in leadership and shared sense of accountability to the organization. As an example, in my current team we have defined our values around the acronym HOOK:Humility, Over-delivering, Optimism and Kindness. We work to incorporate this into daily circumstances to ensure that application of the values to emerging scenarios does not follow a divergent path from what is intended. Driving long-term team alignment, most especially with new members,comes via documenting relevant scenarios for further shared awareness in discussion or training.

Without this contextual application, valuessometimes slip into obscurity or introduce conflict in their interpretation, which can relegate the acronym tooa mnemonic device reinforcing different outcomes and a source of frustration.

There are multiple personality-assessment types used for evaluation of prospective employees. Unfortunately, what is less understood and rarely applied is the ability for those assessments to be used in ongoing employee engagement and growth of interpersonal skills.

I have worked with many clients that have leveraged the DISC method of profiling to onboard employees, which isused at the onset of employment and rarely (if ever) referred to again. My strong recommendation to clients is that such profiles are made available to all team members as a basis for understanding optimal communication methods with the new member, and further using collective team profiles to bring improve collaboration.

As an example using the DISC model, if I was addressing teammate with high Dominance (the "D"in DISC) in a particular situation, I would modulate to being on a direct path towards resolution. If I was instead going to work with an individual with high Conscientiousness ("C") for with a similar scenario, I would instead be focusing on providing significant detail on the situation and path forward. For all distinct profile types, the key opportunity being that the assessment can guide subtle changes in interaction that allow leaders to reduce reluctance and drive clear improvements in communication and influence.

Related:11 Affordable Employee-Morale Boosters

While there are multiple facets to the relationship of an employee to their company, leaders in the organization have a singular potential to shape the health and longevity of the relationship. Key to that is balancing what employees bring on their own against with howleaders can reinforce trustthrough systems the raise the likelihood of success for all.

Related:3 Steps to Ensure Your Presentation Enraptures Your Audience3 Ways Leaders Can Better Discover What People Want6 Ways A Remote Manager Can Kill Your Workplace Culture

Go here to read the rest:
3 Steps to Building the Workplace Culture You Want - The Advocate

Women’s Health, Wealth And Longevity – A Retirement Triple-Threat – Employment and HR – UK – Mondaq News Alerts

Posted on October 4, 2020 by Prof Baldwin

28 September 2020

Gilson Gray

To print this article, all you need is to be registered or login on Mondaq.com.

Because women typically live longer than men and may have asmaller pension pot, they need to plan accordingly to make theirmoney last.

While longevity sounds like a blessing, we wouldn't want tobe unwell and struggling financially during our later-life years.But many women run the risk that this will be their future. Notbecause they've got the 'right genes' or live asuper-healthy lifestyle: it's simply because they were born awoman.

A 40-year-old woman has a one in four chance of living to age96, and a one in ten chance of living to 100.1 Betterhealthcare and positive lifestyle changes have helped to raise lifeexpectancies across the board, but women still are likely to livelonger than men. And with several studies finding that more menthan women have died from COVID-19, the life expectancy gap couldwiden further from here.

Women not only need their pensions to last longer, they alsogenerally have smaller pension pots to use during these extra yearsof life. We already know that women typically retire with one-fifthof the pension wealth of men.2 New analysis from theCentre for Economics and Business Research found that, when lifeexpectancy is taken into account, the gender pensions gap could beas much as 108,130 for single women, and 186,120 forwomen who are married or in a relationship.3

Because they tend to live longer, women are more likely to endup in single-person households later in life. This could addfurther to their financial pressures because it can be much moreexpensive to run a household of one, covering all bills alone.

Adding to this, the State Pension age is rising, which meansmany people who will rely on this government payment will have towork longer before they can claim it. Plus, there's noguarantee your health will support you working into your lateryears.

Some women may have taken their first job at 16. If you'replanning on working until your late 60s or early 70s, that's alot of years in the workforce - you might well be feeling burnt outor struggling with health issues. As early as your mid-40s or early50s, you could be suffering from symptoms of the menopause, such as'brain fog', which can make it tough for some women tocontinue working at the pace they once did.

You may want to drop to part-time hours or get a job with lessresponsibility to take some of the pressure off, even if it justfor a few years. But will you be able to afford it?

For women in same-sex relationships, they may think that theirjoint longevity will give them a long and happy retirementtogether. But in fact they could face a triple whammy ofchallenges: both partners might take a period of maternity leavethat could impact their earning power and pension contributions,both may need to work longer, and both may suffer from healthconditions over their long lives.

Luckily, there are things all women can do to increase yourchances of a financially secure life, however long you live. If youdo nothing else, have a think about what you want your future tolook like. Do an appraisal of all your long-term savings plans,rounding up any small savings pots you may have forgotten aboutover time. Sit down and have a chat with a financial adviser to seehow things are actually looking for your retirement years. Takinginto account the money you've already saved, and your capacityto save over the coming years, an adviser can model a likelyoutcome.

You may find that you can retire sooner than you think or canslow down your working pace as you near retirement if you come upwith a sensible plan now. Take charge today and speak to your St.James's Place Partner for help with your finances.

Footnotes

1. ONS life expectancy calculator, accessed 7 September2020

2. Securing the Financial Future of the Next Generation,Insuring Women's Futures and Chartered Insurance Institute,2018

3. Centre for Economics and Business Research, September2020

The content of this article is intended to provide a generalguide to the subject matter. Specialist advice should be soughtabout your specific circumstances.

POPULAR ARTICLES ON: Employment and HR from UK

Mayer Brown

The topic of employers looking to change employment contract terms is becoming increasingly important as we move towards the end of the Coronavirus Job Retention Scheme (CJRS) and beyond.

Mayer Brown

In our latest episode Nick looks at a case where the employee tried to rely on the GDPR and Human Rights to prevent disciplinary proceedings being taken against her.

See the rest here:
Women's Health, Wealth And Longevity - A Retirement Triple-Threat - Employment and HR - UK - Mondaq News Alerts

Ask Maine Audubon: Why do baby snapping turtles hatch in the fall? – pressherald.com

Posted on October 4, 2020 by Prof Baldwin

Why do snapping turtles often build their nests quite a long walk from the water, instead of right next to it? Also, why do the babies hatch now, instead of in spring like so many other baby animals?

Avi, 4, Portland

Great to hear from a young inquisitive naturalist! Snapping turtles are a great species to study throughout our warmer months because they are fairly common, and their slow movements and large size make them easy to find and observe over time. Ive been tracking one of the snapping turtles at Maine Audubons Gilsland Farm in Falmouth for years. It lays eggs every spring, which gives us a few exciting days every fall when the babies hatch.

We can almost set our clocks to when the female snapping turtle will wander up from the pond to find a spot to lay her eggs. Every year that weve found her, it has been during the first week of June. As Avi notes, she makes the 400- to 500-foot journey from the pond to find someplace that will be safe to lay the eggs. In most cases, I see turtles moving uphill to find dry sandy areas to dig a hole for their eggs. If they lay them too close to the pond or body of water that they live in, they may risk getting the eggs wet or too cold. Temperature is critical for development, and actually determines the sex of the hatchlings: warmer temperatures during embryo development will result in females, colder temperatures result in males.

Predation is also a big problem for snapping turtles, with studies showing that over 80 percent of nests are raided by predators. Many of the animals that would make a meal of a turtles eggs, including raccoons and mink, are likely to be found around the waters or riparian habitats that the turtle lives in. So perhaps moving away from the water could also help lower predation risks.

Just as we can predict the early June laying of eggs, we almost always see baby turtles hatching out during the second week of September. This has varied over the years, with Oct. 10 being our latest hatch date, despite the same June lay day. Unlike the other spring babies that we see with other animals, especially mammals, snapping turtles have a narrower window to reproduce. They can only start mating once theyve emerged from the mud in the spring (we often see turtles mating during our Spring Warbler Walks at Evergreen Cemetery in mid-May). So by the time females lay eggs, the eggs incubate, and then hatch, we find ourselves in September.

There are sometimes reports of eggs that have overwintered in northern regions, probably because they didnt have enough time to incubate, that then hatch out in the spring. Still others can hatch, overwinter underground, and emerge from their nests in spring. Good questions, Avi!

CAN SOLAR PANELS AND BIRDS COEXIST?

Since reading that Paris and Oxford have approved a 30 acre solar panel farm, I have been worrying. Is it true that birds flying over such projects can get fried?

Cynthia Burmeister, Paris, Maine

With climate change arguably the greatest threat to wildlife, human health, and even habitability on this planet, we need to transition to renewable energies as quickly as possible. Acting fast does not mean we should act improperly, and this is where we need to evaluate the different options for a sustainable future, as not all are equal.

The sun sends us energy in the form of solar radiation, and we have several technologies (and more coming) for harnessing this hopefully infinite source of energy. One of those is used in concentrated power facilities, and it has been known to be harmful to birds. These facilities essentially use mirrors to reflect light back to a single point, on a tower, and convert that heat into energy. These systems can heat water to produce steam, or even efficiently store heat in molten salts.

The problem with concentrated solar power facilities is that they use lots, often thousands, of specialized mirrors (heliostats) that essentially create a heat ray. This is practically the same technology that Archimedes used to burn attacking Roman ships during the Siege of Syracuse (213212 BC). Scale up that Greeks science project, and you can imagine how effective these modern facilities are. They can, unfortunately, fry birds that fly through the hot beams. However, to allay Cynthias concerns, concentrated solar power is not very common, and Maine is far from suitable for this technology.

The solar technology that we are seeing a big push for in Maine is generating electricity through photovoltaics. This is basically a plan to scale up the solar panels you see collecting sunlight directly on rooftops and ground-mounted platforms. Photovoltaics represent the cheapest solar electricity source, and Maine is a great place for them, especially for homeowners thanks to the restoration of net-metering by Gov. Janet Mills in 2019. From an environmental impact perspective, photovoltaics are great: they dont produce any pollution or green-house gases. Yes, manufacturing of anything will produce some waste and carbon emissions, but the longevity and efficiency of photovoltaic cells make them one of our best options. And from a birds perspective, there is virtually no harm from photovoltaics themselves.

There is potential for adverse impacts, however, as my colleague Eliza Donahue wrote about in August. Photovoltaic technology is great, and placing them on rooftops or brownfields are ideal, but we need to be cautious in large-scale adoption. Proposals for large solar farms on grasslands, woodlands, or other ecologically productive sites need to be thoughtfully sited and evaluated for long-term impacts to the species that rely on those areas including humans.

Do you have a nature question for Doug? Email questions to [emailprotected] and visit http://www.maineaudubon.org to learn more about virtual and backyard birding, online classes, and other programs about Maine wildlife and habitat.

Invalid username/password.

Please check your email to confirm and complete your registration.

Use the form below to reset your password. When you've submitted your account email, we will send an email with a reset code.

Here is the original post:
Ask Maine Audubon: Why do baby snapping turtles hatch in the fall? - pressherald.com

Top 5 Group Exercise Classes for Your Return to the Gym – Longevity LIVE

Posted on October 4, 2020 by Prof Baldwin

Its not hard to see why yoga has become so popular. In addition to helping with strength, balance, and body awareness, its meditative qualities can help center your life and reduce stress and anxiety. Taking a yoga class with a professional yoga instructor is an absolute must since some moves can be dangerous if not performed properly.

Taking yoga as a group class, additionally, will allow for the meditative qualities of yoga to be enhanced by group participation and will give you the motivation to participate more fully in the spiritual aspects of the practice. Being a group yoga classalso allows you to benefit from the shared, collective energy of the group, and youll be able to leverage that energy throughout your yogic flows. For those who struggle to stay consistent with their yoga effortsparticularly beginnersthese classes can be a great way to create accountability, learn from others, and make it more fun.

Taking a group dance class can be an incredibly fun social experience, especially if you go with your significant other. Dance has many of the same advantages of yoga, including strength, balance, and cardio training, but instead of meditation, it concentrates on interpersonal interaction.

The social aspects of group dance go back to ancient traditions. All over the world, dance would have incredible importance in the ritual life of the community. Many of these ancient rituals have been lost, but some of those social benefits can be tapped into. Be it through swing, salsa, and other group dance classes. In fact, the ability to build close connections with your fellow dancers is one of the biggest benefits.

Because dancing involves physical connection, it allows you to bridge the gap between human interaction and human touch. Group dance classes are also almost always more affordable than private lessons, and youll benefit from getting a firsthand look at how many different people have different styles and approacheseven for the same dance.

Follow this link:
Top 5 Group Exercise Classes for Your Return to the Gym - Longevity LIVE

Sergio Ramos’ titles, longevity for Spain and Madrid are the stuff of legend — and he isn’t slowing down – ESPN

Posted on October 16, 2020 by Prof Baldwin

Sergio Ramos is a freak. It's impossible to deny that fact.

Now, Sergio, if you're reading this, I mean it in the most complimentary way. Not a hint of denigration or disrespect.

But facts are facts.

We live in an age when players are gasping for respite, a breather for their tired limbs to regenerate. Not only that but the merest pause from the endless, vicious cycle of: train, prepare mentally, play, recuperate, train, prepare mentally, play, etc. so that creative players can regain sharpness of instinct and even little flames of inspiration and daring. They all fear their sparks of genius vision and invention will be extinguished.

The evidence that we are squeezing more out of our elite footballers than they should be giving is not only staring us in the face, it's adopting an aggressive "Why don't you care?" expression. In recent days there were reminders -- futile, I'm sure.

- UEFA Nations League on ESPN+: Stream LIVE games and replays (U.S. only)- UEFA Euro 2020 qualifying on ESPN+: Stream LIVE games and replays (U.S. only)

Kevin De Bruyne, a mere stripling at 29 compared to gnarled veteran Ramos (34), warned: "I've played flat out for two years, but nobody listens to the players. It worries me sometimes. Your body is screaming out for a rest but nobody listens to the players."

Then, after Spain's flat and creativity-starved 1-0 win over Switzerland, 23-year-old Pau Torres admitted that the players have felt the strain of a three-game week for their clubs followed by a midweek friendly in Portugal and then this test against the disciplined, athletic, hard-pressing Swiss. Then there was the 7,600-kilometre round trip to Kiev, for a match against Ukraine, to be faced and suffered.

It really is nonstop for these guys.

Mental and physical tiredness against the Swiss cost La Roja those split seconds where an invented action, a brilliant piece of sharp passing or an individual skill properly separates truly top-class players from those who are truly giving their top effort. "But there can't be any such thing as tiredness when you're playing for your country," Torres said.

Then you have Arsene Wenger arguing, while promoting his imminent autobiography, that "the next game changer is neuroscience." Why does he put forward this idea? According to Wenger, "Because we are at the end of the improvement of physical speed."

2 Related

Rate him or not, one of the modern era's most successful and epoch-changing managers believes that, athletically, elite football is already operating at absolute maximum -- pedal to the floor. With the needle steadily edging into the red zone, if this were a car, you'd slow down and find your nearest mechanic.

But not Ramos.

His stated aim, despite his 35th birthday coming in March, is to lead Spain at the European Championship next summer, do the same at the postponed Tokyo Olympics in autumn 2021 and then captain La Roja to the Qatar World Cup in 2022. All the while, no doubt, inspiring Real Madrid to another La Liga title and winning back-to-back Champions Leagues.

These remarkable objectives from a remarkable man need putting in context.

First, Ramos's voracious hunger and stamina. From his debut match for Spain (at 18 he became the country's youngest debutant for 55 years), of all the 17 players used that day, only Joaquin is still a professional footballer. Ditto his debut in a World Cup: the 4-0 thrashing of Ukraine in Germany 2006. Of all starters and substitutes who played that afternoon, only Cesc Fabregas has lasted this long as an active pro. Even if you take the starting XI from the first international final he won, the 1-0 defeat of Germany at Euro 2008, only he, Fabregas, David Silva and Andres Iniesta are still in the game.

And the subject of this man's trophy lifts is important.

Ramos has won the World Cup and two European Championships for Spain, rewriting history, but that didn't sate him as it did others. While teammates, greats at that, silently slipped away -- Iniesta, Iker Casillas, David Villa, Jordi Alba, Pedro -- Ramos powers on.

For his club, the trophy list is gargantuan. Four Champions Leagues, five La Liga titles and a cupboard full of other medals that lesser men don't even get a sniff of.

He still isn't satisfied.

Return our focus to international football and the history he's made outwith lifting trophies begins to explain Ramos' perpetual voracity Regardless of these difficult, unpredictable times, should international football continue as intended, by Euro 2020 Ramos will overtake Egypt's Ahmed Hassan, who is at the top of the all-time appearance list with 184 caps. Of all the players in the top 10, only one (Mexico's Claudio Suarez) earned his caps in a shorter time than Madrid's captain.

Upcoming games live on ESPN+ (U.S. only):FRIDAY, OCT. 16 Tianjin Teda v Shenzhen (3.25 a.m. ET) Hebei CF v Guangzhou Ever. (7.25 a.m. ET) Derby County v Watford (2.40 p.m. ET)SATURDAY, OCT. 17 Shandong L. v Beijing Guoan (3.25 a.m. ET) Dalian Pro v Shijiazhuang Yong. (3.25 a.m. ET) Napoli v Atalanta (8.50 a.m. ET) Mainz v Leverkusen (9.20 a.m. ET) Hoffenheim v Dortmund (9.20 a.m. ET) Freiburg v Werder Bremen (9.20 a.m. ET) Hertha v Stuttgart (9.20 a.m. ET) Augsburg v RB Leipzig (9.20 a.m. ET) Bournemouth v QPR (9.55 a.m. ET) Inter Milan v AC Milan (11.50 a.m. ET) Sampdoria v Lazio (11.50 a.m. ET) Bielefeld v Bayern Munich (12.20 p.m. ET) Gladbach v Wolfsburg (2.25 p.m. ET) Crotone v Juventus (2.35 p.m. ET) Inter Miami v Montreal (7.00 p.m. ET)

Ramos, over his career, hasn't done injuries. That's not to say he's utterly immune -- just fantastically robust. Nor does Ramos pick and choose when he plays for his country. If Spain want him, he's there. Tired? Sore? Family commitments? Rather be fresh for his club? Can't be bothered with the trip to the Faroe Islands, Moscow or Minsk? Those ideas, according to Ramos, are for wimps.

He's the all-time winningest footballer in international history, having overtaken his friend and colleague Casillas, and he's the top-scoring defender in the vast history of football nations pitting themselves against one another.

And he isn't slowing down.

In the past two years, aged from 32 to 34, Ramos has played 108 matches for club and country. In that time, both Spain and Madrid have developed a distinct Ramos dependency. It's not that Real Madrid simply cannot win without him, it's that they lose an essential aggression, competitiveness and self-belief without their leader.

Look at the debacle against Manchester City in the away leg of last season's Champions League round of 16. Without Ramos by his side, Raphael Varane made horrible mistakes, and once they were 2-1 down Madrid utterly lacked the chutzpah, the "We're not beaten until the stadium floodlights are switched off" attitude with which Ramos bristles.

1:01

Sid Lowe marvels at Adama Traore's impact in his first international action with Spain.

Compare that to how he almost single-handedly bullied all domestic rivals out of the way until Real Madrid won the title after La Liga's restart. Ten matches, nine wins, one draw, during which their 34-year-old central defender scored six times -- including the only goal in consecutive victories over Getafe and Athletic Club.

Nor should anyone overlook his record of big goals in Champions League finals. When Madrid were about to lose to Atletico Madrid in the 2014 Lisbon showpiece, Ramos didn't just score the most dramatic of added-time equalisers. No. He told me that he was thinking of his recently deceased grandfather as the minutes ticked away. Thinking to himself, "I can't, I won't let this match finish this way." And he didn't.

From that day to this, Madrid haven't found someone to replicate the Ramos effect. Cristiano Ronaldo was cut from the same cloth but when, if, Ramos ever departs this team, it'll be hell on earth to find anyone with the same mix of extraordinary talent, athleticism, technique, character and sheer, naked will to win.

It's the same for Spain. In his past 17 internationals, and please remember we are talking about a defender, he's scored nine times. He's their most potent striker. And while Luis Enrique has some productive scorers scattered throughout his squad, if Ramos doesn't hit the net, La Roja often struggle and look dry in front of goal.

Throughout his career he's taken 31 penalties and missed just three. Most importantly, though, he's scored 22 consecutively for Madrid and Spain since he last failed. He is metronomic from the spot.

Dan Thomas is joined by Craig Burley, Shaka Hislop and others to bring you the latest highlights and debate the biggest storylines. Stream on ESPN+ (U.S. only).

The key thing to understand about Ramos is that he's a buccaneer, someone from times gone by. He's an adventurer, a rascal, someone who lives life to the absolute limit; someone who sees horizons where others see walls and boundaries; someone who, when young, truly wanted to be a bull fighter; a man who's always wanted not just to win but to tilt against the odds, the bigger the better; and he's someone who simply loves the training, playing and competing involved in football.

Recently, he told UEFA: "I'm full of motivation. You have to reset every year and start from scratch; to live each triumph, every trophy win, as if it were a completely new thing. I think it's very positive to continue enjoying football like this, without looking back, without stopping to think what you have done or achieved. This is how it feels like there is a whole life ahead of you when your body is trying to tell you that you can't do it any longer.

"In principle, just so long as I'm as full of inspiration, pride and hunger, then I'll treat the World Cup in Qatar as another challenge. I want to play in it and increase my number of caps. If I can make it to 200 appearances for Spain then all the better."

They were born just two months and 990 km apart in 1986, but when you see Rafa Nadal hurting, fighting, recovering lost causes, equalling title winners who, perhaps, were thought to be slightly more conventionally talented than him, try seeing Ramos instead. Two peas in a pod: Spanish, proud, aggressive, athletically brilliant, perpetually inspired, self-motivated, deaf to both critics and those who say, "Not this time, he won't be able to ..."

Two fabulous freaks: men who are easy to admire, impossible to ignore and who give meaning to the whole idea of sport as a means to test the boundaries of what human beings can reasonably achieve.

Read the original here:
Sergio Ramos' titles, longevity for Spain and Madrid are the stuff of legend -- and he isn't slowing down - ESPN

COVID-19 Cross-Sector Impact Thematic Research, Q3 2020 – ResearchAndMarkets.com – Business Wire

Posted on October 4, 2020 by Prof Baldwin

DUBLIN--(BUSINESS WIRE)--The "COVID-19 Cross-Sector Impact - Thematic Research (July 2020)" report has been added to ResearchAndMarkets.com's offering.

This report analyzes the impact of COVID-19 across industry sectors. It provides side-by-side analysis of alternative datasets to present you with unique quantitative analysis of the effects of COVID-19 and how these differ across sectors. We also provide qualitative analysis of each sector and analyse COVID-19's impact on leading companies.

According to John Hopkins University data, by 28 July 2020, COVID-19 had infected more than 16.4 million people and claimed 650,000 lives. The pandemic forced governments to impose rigid lockdowns that essentially shut down the worldwide economy for many months. With the exception of India and China, all major economies are expected to shrink this year. Unemployment levels have increased at jaw-dropping rates.

The COVID-19 recession has not been caused by a demand shock, rather, it is a policy-driven supply shock designed to save people's lives. Consequently, the strategies-of governments and companies-that will be used in the economic recovery could be different from previous recessions.

Despite the substantial uncertainty regarding the economic downturn, this could well be the first recovery with a focus on sustainability. The human cost of COVID-19 extends beyond infection and into the broader economy. Companies that ignore social, environmental and governance issues could face significant customer backlash. Governments are already showing signs that sustainability-particularly green energy-will feature strongly in stimulus programs.

The way we live our lives has been changed permanently. However, the extent to which human life will change will be affected by two competing factors: the longevity of COVID-19's presence and the speed with which a vaccine is developed. Most enterprises successfully transitioned to work from home; few will revert back to pre-COVID-19 practices. Many staff will opt to work from home at least part of the week. There will be ramifications for the way we plan our future cities and future transportation networks, as well as for the commercial property sector.

Scope

Reasons to Buy

For more information about this report visit https://www.researchandmarkets.com/r/uul0zn

More here:
COVID-19 Cross-Sector Impact Thematic Research, Q3 2020 - ResearchAndMarkets.com - Business Wire

The New Face of Integrated Planning and Design – D Magazine

Posted on January 8, 2021 by Prof Baldwin

It is estimated the world will invest 94 trillion U.S. dollars in infrastructure globally in the next 20 years. With that level of investment, we should ask some important questions. What is the best approach we should use today to deliver these projects? How can we incorporate climate change, social equity, and sustainability into our project planning? What is the future of our engineering practice?

One thing 2020 has taught uswe cant solve problems as we did before. Todays infrastructure investment must include new thinking. Through innovation, every project, regardless of sector, needs the longevity to last several decades and incorporate forward-thinking innovations to solve future challenges today. We must start to apply green box thinking.

Rami Issa, AECOM

Cities, developers, architects, and engineers are increasingly looking for ways to move away from the concrete jungle and incorporate elements of nature into our everyday lives. This focus on more sustainable development is the same approach we should take when evaluating infrastructure.

Many of us are familiar with gray infrastructurethe more traditional, concrete, human-engineered solutions however, green infrastructure is a solution worth exploring and implementing alongside gray infrastructure. It refers to natural elements of our ecosystem, such as forests, reefs, and wetlands, which can serve many of the same gray infrastructure functions.

When you blend both green and gray infrastructure together, the result is a cohesive solution that helps address community resiliency future challenges. In many instances, incorporating green infrastructure into future infrastructure investments may boost eco-tourism and generate new revenues for local communities.

Green infrastructure can take many forms, from protected natural areas to green roofs in cities. The goal is to employ nature to provide natural benefits such as clean air or reliable flows of clean water. By blending conservation and restoration techniques with innovative engineering, green-gray infrastructure provides solutions enabling communities to mitigate natural disasters and adapt to a changing climate. However, the challenge is strategically combining the two.

To further advance the science and practice of green-gray infrastructure, the Green-Gray Infrastructure Community of Practice (GGI COP) was established. It will blend conservation and restoration of nature with human-made engineering approaches to fortify communities against climate effects.

AECOM co-founded the initiative with Conservation International, a global leader in environmental conservation and sustainable development. Conservation International plans to release a practical guide for GGI implementation, which will be a tool for engagement with local governments, clients, universities, and field staff to support project implementation.

Flooding resiliency is one area where green-gray infrastructure can help provide a solid solution. GGI COP estimates the number of people impacted by floods will double worldwide by 2030. While conventional engineering approaches of upsizing stormwater conveyance and storage systems may have near-future benefits, they do not incorporate future challenges such as climate change and social and economic shifts. These projects can be very costly to construct, and stop-gap solutions only kick the can down the road.

Flooding continues to be a challenge in North Texas, and tackling it head-on requires a new way of thinking. Collaboration and partnerships among many stakeholders in our North Texas community must deliver integrated infrastructure solutions that incorporate green and gray infrastructure together. These solutions should incorporate regional transportation, stormwater management, and environmental planning into regional infrastructure projects.

Now, how do we blend green and gray infrastructure solutions? We do it by adding purpose, beauty, value, equity, and resiliency through each project by transforming the way we perform integrated planning and design.

Integrated planning and design have the power to transform a community into the next level and incorporate restorative environments within urban density. A shift from reactive planning into a proactive planning approach will solve todays challenges and account for future challenges. This is the future of practice, no doubt.

Rami Issa is the DFW Water Business Line Leader at AECOM.

Read this article:
The New Face of Integrated Planning and Design - D Magazine

Cellular Reprogramming Tools Market: COVID19 Impact- Recent Industry Developments and Growth Strategies Adopted by Top Key Players:Human Longevity,…

Posted on September 9, 2020 by Prof Baldwin

The Insight Partners dedicated research and analysis team consist of experienced professionals with advanced statistical expertise and offer various customization options in the existing study.

Worldwide Cellular Reprogramming Tools Market Analysis to 2027 is a specialized and in-depth study of the Teeth Whitening industry with a focus on the global market trend. The report aims to provide an overview of global Cellular Reprogramming Tools Market with detailed market segmentation by product & services /application and geography. The global Cellular Reprogramming Tools Market is expected to witness high growth during the forecast period. The report provides key statistics on the market status of the Teeth Whitening players and offers key trends and opportunities in the market.

To get sample Copy of the report, along with the TOC, Statistics @ https://www.theinsightpartners.com/sample/TIPRE00013960/

Here we have listed the top Cellular Reprogramming Tools Market companies in the world

Highlights the following key factors:

1) Business description-A detailed description of the companys operations and business divisions.

2) Corporate strategy Analysts summarization of the companys business strategy.

3) SWOT Analysis-A detailed analysis of the companys strengths, weakness, opportunities, and threats.

4) Company history Progression of key events associated with the company.

5) Major products and services-A list of major products, services, and brands of the company.

6) Key competitors A list of key competitors to the company.

7) Important locations and subsidiaries A list and contact details of key locations and subsidiaries of the company.

8) Detailed financial ratios for the past five years The latest financial ratios derived from the annual financial statements published by the company with 7 years history.

What does this report deliver?

The report provides a detailed overview of the industry including both qualitative and quantitative information. It provides overview and forecast of the global Cellular Reprogramming Tools Market based on product and application. It also provides market size and forecast till 2027 for overall Cellular Reprogramming Tools Market with respect to five major regions, namely; North America, Europe, Asia-Pacific (APAC), Middle East and Africa (MEA) and South America (SAM), which is later sub-segmented by respective countries and segments. The report evaluates market dynamics effecting the market during the forecast period i.e., drivers, restraints, opportunities, and future trend and provides exhaustive PEST analysis for all five regions.

Table of Content:

Place a Purchase Order to Buy a Complete Copy of this Report @ https://www.theinsightpartners.com/buy/TIPRE00013960/

About Us:The Insight Partners is a one stop industry research provider of actionable intelligence. We help our clients in getting solutions to their research requirements through our syndicated and consulting research services. We are a specialist in Technology, Semiconductors, Healthcare, Manufacturing, Automotive and Defense.

Cellular Reprogramming Tools Market analysis

View post:
Cellular Reprogramming Tools Market: COVID19 Impact- Recent Industry Developments and Growth Strategies Adopted by Top Key Players:Human Longevity,...

Global Adrenomyeloneuropathy Treatment Market Size, Share, Trends, CAGR by Technology, Key Players, Regions, Cost, Revenue and Forecast 2020 to 2025 -…

Posted on November 7, 2020 by Prof Baldwin

New Market Research Report: on Adrenomyeloneuropathy Treatment Market size | Segment by Applications (Hospitals, Clinics, Ambulatory Surgical Centers and Others), by Type (Steroid Replacement Therapy and Stem Cell Transplant), Regional Outlook Opportunity, Market Demand, Latest Trends, Adrenomyeloneuropathy Treatment Industry Share & Revenue by Manufacturers, Leading Companies Profiles, Analysis, Growth Forecast 2025. Analyzes current market size and upcoming Few years' growths of this industry.

Adrenomyeloneuropathy Treatment Market Size report is the best source that gives CAGR values with variations during the forecast period of 2020-2025 for the market. The study encompasses market drivers and restraints by using SWOT analysis, along with their impact on the demand over the forecast period. This global market report endows with a profound overview of product specification, product type, production analysis, and technology by taking into consideration the major factors such as revenue, cost, and gross margin. The Adrenomyeloneuropathy Treatment advertising report has been prepared based on the market type, size of the organization, availability on-premises, and the end-users organization type.

Some of the prominent players operating in the global Adrenomyeloneuropathy Treatment market include Ascend Biopharmaceuticals, Immatics Biotechnologies, Human Longevity, Novadip Biosciences, BioRestorative Therapies, Eureka Therapeutics, Cytori Therapeutics, Allogene Therapeutics, Regeneus, NewLink Genetics and Talaris Therapeutics among others.

Request Sample Copy of this Report @ https://www.express-journal.com/request-sample/240610

Competitive Analysis: Adrenomyeloneuropathy Treatment Market

Global Adrenomyeloneuropathy Treatment market Size is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of Adrenomyeloneuropathy Treatment market Share for global, Europe, North America, Asia-Pacific, South America, and Middle East & Africa.

Global Adrenomyeloneuropathy Treatment Market Split by Product Type and Applications:

Based on Types:

Based on Application:

The latest research on the Adrenomyeloneuropathy Treatment Market Size fundamentally delivers insights that can empower stakeholders, business owners, and field marketing executives to make effective investment decisions driven by facts and extremely thorough research. The study aims to provide an evaluation and deliver essential information on the competitive landscape to meet the unique requirements of the companies and individuals operating in the Adrenomyeloneuropathy Treatment Market for the forecast period, 20202025. To help firms comprehend the Adrenomyeloneuropathy Treatment industry in multiple ways, the report exhaustively assesses the share, size, and growth rate of the business worldwide.

Report Highlights:

The report covers the shifting industry dynamics

Detailed information about the market segmentation

Covers past, present and projected industry size Recent industry trends

Key Competition landscape

Business strategies of key players and product offerings

Potential and niche segments/regions exhibiting promising growth

A neutral perspective towards market performance

Queries Resolved In This Report:

Which will be the specialties at which Adrenomyeloneuropathy Treatment Market players profiling with intensive designs, financials, and ongoing headways should set nearness?

Which will be the foreseen development rates for your own Adrenomyeloneuropathy Treatment economy out and out and each portion inside?

Which will be the Adrenomyeloneuropathy Treatment application and sorts and estimate joined intently by makers?

Which will be the dangers which will attack growth?

The length of the global Adrenomyeloneuropathy Treatment market opportunity?

How Adrenomyeloneuropathy Treatment Market share advance vacillations of their value from various assembling brands?

Chapters Define in TOC (Table of Content) of the Report:

Chapter 1: Market Survey, Drivers, Restraints and Good fortune, Segmentation overview

Chapter 2: Market competitiveness by Manufacturers

Chapter 3: Production by Regions

Chapter 4: Consumption by Regions

Chapter 5: Production, By Types, Revenue and Market share by Types

Chapter 6: Consumption, By Applications, Market share (%) and Growth Rate by Applications

Chapter 7: Overall profiling and analysis of Manufacturers

Chapter 8: Manufacturing cost analysis, Raw materials analysis, Region-wise manufacturing expenses

Chapter 9: Supply Chain, Sourcing Strategy and Downstream Buyers

Chapter 10: Marketing Strategy Analysis, Distributors/Traders

Chapter 11: Market Influence Factors Analysis

Chapter 12: Market Predict

Chapter 13: Adrenomyeloneuropathy Treatment Research Findings and Conclusion, Appendix, methodology and data source

Request Customization on This Report @ https://www.express-journal.com/request-for-customization/240610

Continue reading here:
Global Adrenomyeloneuropathy Treatment Market Size, Share, Trends, CAGR by Technology, Key Players, Regions, Cost, Revenue and Forecast 2020 to 2025 -...

Select Page ::