Diagnostic BioSystems Launches the First Automated IHC Multiplex Platform for Anatomic Pathology

PLEASANTON, Calif.--(BUSINESS WIRE)--

Diagnostic Biosystems (DBS), a specialty Immunohistochemistry company, announces its debut as an automated IHC company, introducing the Mosaic 360 System with a product offering of novel Multiplex Immunohistochemistry kits and a complementary line of optimized IHC reagents.

Built on a history of developing distinctive chromogens to differentiate morphology on a single slide, Diagnostic BioSystems introduces a portfolio of five Mosaic Multiplex Lung Cancer Kits for use in tissue analysis of suspected Lung Cancer patients. Pathologists are challenged with scarce tissue availability in patients with cancer. DBS is addressing the tissue challenge with the Mosaic Multiplex kits enabling testing of multiple analytes on one slide with a complete kit optimized for the DBS Mosaic 360 System automated platform for lab to lab standardized results.

The Mosaic System also includes a new line of plug and play reagents optimized on the Mosaic 360 platform to provide convenience for the Histology Technologist in the Pathology laboratory.

Diagnostic Biosystems is focused on developing clinically relevant tools for pathologists. We believe it is important to provide the most information with the limited tissue available in cancer patients today. Our standardized Mosaic Multiplex lung cancer kits are focused on solving this problem, said Dr. Bipin Gupta, PhD, President & CEO of Diagnostic BioSystems.

During the USCAP, Diagnostic BioSystems will sponsor a Pathologist Roundtable event on Tuesday, March 20, 2012 in Vancouver BC to discuss advances in the use of Multiplex Kits in the analysis of suspected cancers. Two industry experts, Dr. Omar Hameed from Vanderbilt and Dr. Arundhati Rao from Scott & White Healthcare System, will join Marc Key Ph.D., DBS Scientific Advisor, in leading these discussions.

A new US distribution organization will support the launch of the Mosaic 360 System.

For additional information on product availability, contact customer care at 888-896-3350 or visit http://www.dbiosys.com.

About Diagnostic Biosystems: Diagnostic Biosystems, based in Pleasanton, California develops high quality Immunohistochemistry reagents for global distribution. Diagnostic BioSystems operates under FDA 21CFR Quality System Regulations, is a CDPH licensed Medical Device Manufacturing facility and is certified under ISO 9001:2008 Quality Management System International standards, manufacturing CE marked products for use in the European market.

Originally posted here:
Diagnostic BioSystems Launches the First Automated IHC Multiplex Platform for Anatomic Pathology

Psyche Systems Corporation and Aperio® Announce Availability of Their Fully Integrated Anatomic Pathology System

MILFORD, Mass., and VISTA, Calif., March 19, 2012 /PRNewswire/ --Psyche Systems Corporation and Aperio announced today that they have joined forces to offer the most advanced anatomic pathology information system available. With this seamless, integrated solution, pathologists can immediately access, manage, and evaluate their whole digital slide images, eSlides, within their WindoPath LIS via intuitive step-by-step workflows.

The integration of Aperio ePathology eSlide Manager and Psyche Systems WindoPath Anatomic Pathology Software enables single sign-on and automatic, bi-directional data transfer in support of the Pathologist's workflow--improving the efficiency and quality of laboratory pathology services.

The companies are launching the integrated solution at the USCAP Conference, March 17 23, 2012. Attendees of the conference are invited to visit both companies on the exhibit floor to learn more about how laboratories can optimize their operations with this new level of streamlined integration. Psyche Systems is in booth #808; Aperio is in booth #910.

About Psyche Systems Corporation Since 1976, Psyche Systems has delivered products that help laboratories of all sizes run more efficiently and cost-effectively. Psyche's WindoPath AP system, Clinical LIS, e.Outreach, EMR Internet Interface, MicroPath, and SBB blood bank software deliver a completely integrated solution for all areas and types of laboratories. Psyche's products are fully integrated or stand-alone and support full automation, integration with instruments, clinical and back-office systems, Outreach and Meaningful Use initiatives. For more information, visit http://www.psychesystems.com.

About AperioFor over a decade, Aperio has advanced the technology that enables glass slides to be digitized and securely shared with others. Aperio products are transforming the practice of pathology in hospitals, reference labs and pharmaceutical and research institutions around the world. From the moment glass slides are digitized to eSlides, Aperio ePathology Solutions equip pathologists with the power to evaluate, engage and excel like never before. The NETWORK enables remote, simultaneous, real-time viewing and easy distribution for consults and collaboration. PRECISION tools empower pathologists with advanced analytic capabilities. An interoperable, scalable and secure web-based software platform facilitates integration with existing systems. With Aperio ePathology Solutions, organizations can optimize their pathology operations for transparency, consistency and efficiency to support patient care, personalized medicine and research. Aperio's products are FDA cleared for specific clinical applications, and are intended for research and education use for other applications. For clearance updates, specific product indications and more information please visit http://www.aperio.com.

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Psyche Systems Corporation and Aperio® Announce Availability of Their Fully Integrated Anatomic Pathology System

Brochures from LLTech – Visit booth #430 at USCAP

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Here are some .pdf brochures from LLTech regarding their Light-CT Scanner Fast Tissue Imaging System, a paper on full-field optical coherence tomography for skin imaging accepted in Dermatology, a paper from the Journal of Pathology Informatics about modified full-field coherence tomography for rapid histology of tissues and finally a paper under review for publication about full-field optical coherence tomography for human breast tissue and breast cancer.

LLTech will be at USCAP 2012 occupying booth 430.

Download LLTECH brochure March 2012

Download FFOCT skin imaging - accepted in Dermatology

Download JPatholInform_2011 Cornell

Download Large field FF-OCT on breast

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ViewsIQ at USCAP Booth #814

 

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ViewsIQ at USCAP Booth #814

Come see your slides in a whole new way 

 

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ViewsIQ has invented PanoptiqTM, an interactive digital slide imaging tool built exactly for YOU, the pathologist. Designed and trialed by top pathologists at Canada's premier healthcare institutions, PanoptiqTM empowers you to create panoramic images of your slides "on the fly" right under your own microscope. This allows you to see and communicate diagnostic information of the slide in a whole new way.

What is it?

The PanoptiqTM system begins with your microscope, manually driven by you. By adding a camera and computer with our PanoptiqTM software to your microscope, you have created a whole new way to view and share your slides. The PanoptiqTM system allows you to create panoramic images of the slide in real-time at extremely high resolution with any objective, even a 100x oil objective.

Where can you see that? ViewsIQ welcomes you to USCAP at booth #814 in Vancouver.

What will you experience?

Interactively capture panoramic images of pathology slides using 4x to 100x objectives. 

Product Information

Observe and build a panoramic image on the fly 

Build a larger field of view of the tissue sample under microscopic observation by merely navigating the slide with a manual stage. Normally, the tissue sample is observed through a small field of view under the microscope. In contrast, PanoptiqTM captures the fields of view as you observe the tissue sample and automatically stitches them "on the fly" into one panoramic image. At any time, you can navigate and save the panoramic image on the computer through our user-friendly interface. With desktop sharing software, You can even share the live view of the panoramic image for live consultations, tumor boards, and education.

Refocus the Image

Detect an out-of-focus portion in the panoramic image? Just return to that portion of the slide and readjust the focus with your microscope – the software automatically detects a better focus and replaces the out-of-focus portion with the refocused view. The PanoptiqTM system preserves the best focus achieved on the panoramic image, even if the slide is observed again at a sub-optimal focus.

Simple Setup

The PanoptiqTM system includes a high performance computer, high resolution CCD Camera, and the PanoptiqTM software. System setup is simple. The system can be installed and ready to go within 15 minutes. Extended warranty and support packages are available. Please come to our booth for more information. Representatives from our distributors, Innovative Imaging Concepts and Quorum Technologies, will also be there to help meet your needs.

 

Company information:

ViewsIQ #115-887 Great Northern Way

Vancouver, BC V5T 4T5

Phone (toll-free): 1-855-VIQ-SCAN (1-855-847-7226) Fax: 416-907-1670

Email: info@viewsiq.ca

Website: http://www.viewsiq.ca

USA Distributor:

Innovative Imaging Concepts

340 Main Street Oxford, MA 01540

Phone: 508-581-0251 Fax: 508-987-7310

E-mail: info@innovative-imaging.net

Website: http://www.innovative-imaging.net

Canada Distributor:

Quorum Technologies

4673 Wellington Road #35 RR# 6

Guelph, Ontario N1H 6J3

Tel: 519-824-0854 Fax: 519-824-5845

E-mail: info@quorumtechnologies.com

Website: http://www.quorumtechnologies.com

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Digital pathology job opening at Roche

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Who we are

At Roche, 80,000 people across 150 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity, and on seeing each other’s differences as an advantage. To innovate healthcare, Roche has ambitious plans to keep learning and growing – and is seeking people who have the same goals for themselves.

POSITION SUMMARY: 

The imaging scientist will utilize expertise in image processing, machine learning, and pattern recognition and contribute as a member of a highly collaborative team of senior engineers and scientists on initiatives pertaining to the development of imaging technology for Digital Pathology.

ESSENTIAL FUNCTIONS:
- Design and develop innovative algorithms for quantitative analysis of histopathology images
- Design, develop and test high-performance analysis engine that can interface with multiple applications. 
- Utilize skills in C/C++, C# and .Net to work on the infrastructure and applications for analysis of digital pathology images. 
- Develop libraries, applications and algorithms for analysis of small and large histopathology images. 
- Building a scalable system capable of handling huge amounts of data with a large user base. 
- Provide technical and/or professional coordination and leadership in the execution of day-to-day program activities, as appropriate to Company objectives
- Collaborate with other technical staff in R&D related to areas such as infrastructure applications, storage and archival systems, and analysis engines. 
- Collaborate with other members of the project team to meet defined scientific and technical needs, expectations and goals. 
- Proactively recommend, and execute tasks and strategies in support of BioImagene’s various product requirements. Partner throughout the research, development and product lifecycle with Core Engineering and TSG Programs, and other related Company business units. 
- Other duties as may be assigned by management in the pursuit of the operational goals of Company 

Who you are

 You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies, and where a job title is not considered the final definition of who you are, but the starting point.

MINIMUM QUALIFICATIONS:

Formal Training/Education:
Ph.D. degree in Computer Science, Engineering or related field, entry level, or Master's degree with 3+ years relevant experience.
 
Experience:

-Product development experience with a focus on data analysis. A PhD may be considered in lieu of product development experience. Proven track record for innovations in problems solving and analysis
- Candidate should have both a solid practical background with experience in C/C++, and software design and architecture.
- Experience in the design and development of image analysis algorithms for medical images. 
- Experience working throughout the full SDLC (software development lifecycle) from concept to product deliverables through system deployment
 
Knowledge, Skills, and Abilities:
-Strong understanding and experience in developing pattern recognition algorithms in large datasets. 
-The candidate should enjoy solving complex problems using a mixture of creative ideas that you bring to the table.
-Hands on software development and implementation of image processing algorithms are required. 
-Understanding and following of Software Engineering practices is required. 
-Understanding of image processing as it relates to the development of biomedical image analysis is highly desired. 
- Excellent knowledge of image processing and understanding, Machine Vision, and Pattern Recognition
- Practical knowledge of Machine Learning based methods and techniques
- Excellent background in C/C++, data structures, performance tuning
- Excellent skills in design of high performance software systems
- Strong Object Oriented Programming design, development and practice
- Strong understanding of MVC and other design patterns 
- Understanding of digital Pathology is desirable but not required
-The position requires the candidate to have good mathematical and analytical skills and through knowledge of basic and advanced image processing techniques.
-Excellent written and verbal communication skills required.

Roche is an Equal Opportunity Employer

Link to Roche online application page

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Definiens at USCAP 2012

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Are you thinking about how to unlock the full potential of digital slides most effectively? Correlate unbiased and quantitative readouts provided by automated image analysis with patient outcome or therapy response. Retrieve comprehensive morphological fingerprints and molecular expression profiles on a cell-by-cell basis from digital slides.

Definiens solutions for Quantitative Digital Pathology support your goals in R&D, pre-clinical safety, clinical studies, translational medicine and the development of tissue diagnostics. Visit us at booth #807 to learn more on the novel functionality available with Definiens Tissue Studio 3.5 and the recently introduced Definiens Image Miner.

The following talks by some of our customers will provide an excellent overview of benefits from using Definiens solutions for image and data analysis:

[2139] Novel Quantitative Image-Analysis Based Scoring Technique for In-Situ Assessment of mRNA in Archival Tumor Tissues: Strong Correlation between Manual and Automated Schemes Authors: Jeffery C Hanson, Timothy R Holzer, Angie D Fulford, Robert J Konrad, Aejaz Nasir   Date/Time: Monday, March 19, 2012 - 1:00 PM   Session Info: Poster Session II # 308, Monday Afternoon   Location: CC Exhibit Hall B3 & C

[1389] Automated Image Analysis and Scoring of Tartrate Resistance Acid Phosphatase Preparations  Authors: Bryan Dangott, Mohamed Salama   Date/Time: Wednesday, March 21, 2012 - 9:30 AM   Session Info: Poster Session V # 212, Wednesday Morning   Location: CC Exhibit Hall B3 & C

[1634] Validation of Automated Image Analysis for Hematopathology   Authors: Bryan Dangott, Nisha Ramesh, Tolga Tasdizen, Mohamed Salama   Date/Time: Tuesday, March 20, 2012 - 1:00 PM   Session Info: Poster Session IV # 221, Tuesday Afternoon   Location: CC Exhibit Hall B3 & C

[1487] Notch/HES1 and PARP1 Protein Co-Expression among B-Lymphoblastic Leukemia/Lymphoma Patients (pts) Predicts Good Prognosis    Authors: Adnan Mansoor, Payam Pournazari, Michelle Dean, Sarah-Joy Haggstrom, Brant Pohorelic, Farid Kosari, Meer-Taher Shabani-Rad, Jay Patel, Iwona Auer, Xiu Yan Jiang, Doug Demetrick, Nizar Bahlis, Douglas Stewart, Alexander C Kilmowicz   Date/Time: Monday, March 19, 2012 - 2:00 PM   Session Info: Platform Session: Section C, Monday Afternoon   Location: CC 211-214

We hope to meet you in Vancouver!

The Definiens Team

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Voicebrook and Nuance Partner to Provide Speech-Powered Reporting Solutions for Anatomic Pathology Laboratories

Interesting agreement announced today between Voicebrook and Nuance Communications combining two industry leaders with their respective technologies related to anatomic pathology reporting further strengthens VoiceOver and Dragon products.   

Voicebrook and Nuance Partner to Provide Speech-Powered Reporting Solutions for Anatomic Pathology Laboratories

 Nuance’s Dragon® Medical 360 Technology to Power Voicebrook’s Industry-Leading VoiceOver® Software

LAKE SUCCESS, NY, March 14, 2012 – Voicebrook today announced an agreement with Nuance Communications, Inc. (NASDAQ: NUAN), in which the two leaders in clinical documentation solutions will work together to deliver comprehensive, speech-enabled reporting solutions for anatomic pathology laboratories. Voicebrook will adapt its industry-leading VoiceOver® software to maximize and incorporate the benefits of Nuance’s Dragon® Medical 360 | Network Edition products.

Powered by Nuance’s advanced speech recognition technology, VoiceOver® is a key component in optimizing anatomic pathology Laboratory Information System (LIS) and Digital Pathology workflows.  Used by more than 200 of the most prestigious private and hospital laboratories across the United States and Canada, VoiceOver® is proven to deliver enormous savings, efficiencies, and quality improvements to anatomic pathology laboratories.   

“We have partnered with Nuance for over 10 years to bring high-quality speech recognition-based reporting solutions to healthcare organizations.  Our latest agreement expands on this relationship and allows us to provide the most comprehensive speech recognition and reporting solutions for the pathology market,” said Joseph Desiderio, President, Voicebrook.  By pairing VoiceOver®, our industry-leading Pathology reporting solution, with Nuance’s award-winning Dragon® Medical 360 line of products, we can offer pathology departments the most advanced solution possible.  We are excited to expand our relationship with Nuance and provide our customers with the healthcare industry’s premier speech platform.  The combination of Nuance’s expertise in creating world-class medical speech recognition applications and our deep knowledge and history in creating pathology reporting solutions makes us uniquely qualified to address the needs of this diverse and challenging market.”

VoiceOver® includes “Integration Personalities” that voice-optimize all major LIS and Digital Pathology systems, allowing pathology professionals to choose between 100 percent user created, and digital dictation or delegated speech recognition solutions.  VoiceOver® can also be used to incorporate voice and additional automation to improve other processes including gross photography, slide labeling, even coding and billing. 

“By combining Nuance’s Dragon Medical speech recognition and Voicebrook’s experience in developing and implementing pathology reporting solutions, the companies will deliver high-value solutions, empowering pathologists to rapidly create comprehensive, accurate pathology reports at a significant savings and with near-instant turnaround time, versus laboratory-wide traditional transcription or digital dictation-based solutions,” said Carina Edwards, vice president, healthcare solutions, Nuance Healthcare.   

For more information, please visit http://www.voicebrook.com. 

About Voicebrook

Voicebrook is the leading provider of integrated speech recognition and digital dictation solutions for Pathology. Voicebrook’s VoiceOver® software integrates directly with most AP/LIS systems, and has been widely deployed in Pathology throughout the US and Canada.  Voicebrook has developed specific best practices for implementation and on-going support, ensuring the most successful deployments of integrated speech recognition technology for Pathology.

Nuance Healthcare

Nuance Healthcare, a division of Nuance Communications, is the market leader in providing clinical understanding solutions that accurately capture and transform the patient story into meaningful, actionable information.  Thousands of hospitals, providers and payers worldwide trust Nuance voice-enabled clinical documentation and analytics solutions to facilitate smarter, more efficient decisions across the healthcare enterprise.  These solutions are proven to increase clinician satisfaction and HIT adoption, supporting organizations to achieve Meaningful Use of EHR systems and transform to the accountable care model.  Recognized as “Best-in-KLAS” 2004-2011 for Voice Recognition we invite you to learn more, http://www.nuance.com/for-healthcare/index.htm

Connect with Nuance Healthcare on:

For the Health of IT blog: http://nuancehealthcareblog.com/

Twitter: http://bit.ly/NuanceHCTwitter

Facebook: http://on.fb.me/NuanceHCfacebook

YouTube: http://bit.ly/NuanceHCYouTube

LinkedIn: http://linkd.in/NuanceHCLinkedIn

 

Source: Voicebrook

 

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An open source robo surgeon

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RAVENS have a bad reputation. Medieval monks, who liked to give names to everything (even things that did not need them), came up with “an unkindness” as the collective noun for these corvids. Blake Hannaford and his colleagues at the University of Washington, in Seattle, however, hope to change the impression engendered by the word. They are about to release a flock of medical robots with wing-like arms, called Ravens, in the hope of stimulating innovation in the nascent field of robotic surgery.

Robot-assisted surgery today is dominated by the da Vinci Surgical System, a device that scales down a surgeon’s hand movements to let him make tiny incisions. That leads to less tissue damage, and thus a quicker recovery for patients. Almost 2,000 da Vincis have been made, and they are used in about 200,000 operations a year around the world, most commonly hysterectomies and prostate removals.

But the da Vinci is far from perfect. It is immobile and weighs more than half a tonne, which limits its deployability, and it costs $1.8m, which puts it beyond the reach of all but the richest institutions. It also uses proprietary software. Even if researchers keen to experiment with new robotic technologies and treatments could afford one, they cannot tinker with da Vinci’s operating system.

None of that is true of the Raven. Originally developed for the American army by Dr Hannaford and Jacob Rosen of the University of California, Santa Cruz, as a prototype for robotic surgery on the battlefield, it is compact, light and cheap (relatively speaking) at around $250,000. More importantly for academics, it is also the first surgical robot to use open-source software. Its Linux-based operating system lets anyone modify and improve the original code, creating a way for researchers to experiment and collaborate.

Universities across America took delivery of the first brood of Ravens in February. At Harvard, Rob Howe and his team hope to use a Raven to operate on a beating heart, by automatically compensating for its motion. At the moment, heart surgery requires that the organ be stopped and then restarted. At the University of California, Los Angeles, meanwhile, Warren Grundfest is working on ways to give the robot a sense of touch that is communicated to the operator. Pieter Abbeel and Ken Goldberg at the University of California, Berkeley, will try teaching the robot to operate autonomously by mimicking surgeons. And Dr Rosen himself will work on ways to get human and robotic surgeons to work together.

Crucially, although individual laboratories will retain the rights to their own particular innovations, the results of these studies, and the improvements they suggest, will be stored in an online repository available to all. What happens after that is less certain. The research-oriented Raven has not yet been approved by American regulators, so all these investigations are, for the moment, restricted to operations on animals or human cadavers. And there is another, legal, problem. Intuitive Surgical, the company behind the da Vinci, holds patents that could make launching a commercial competitor tricky—at least in the immediate future.

Once those patents expire, however, the University of Washington could spin off the Raven into a start-up company. In the meantime, four more universities, including two outside America, have expressed an interest in buying one of the new robots. And even those without $250,000 to spare can participate in its development. The University of Washington is releasing a graphical simulation of the Raven that can be used to test its control system virtually. Dr Hannaford hopes that robotics researchers and amateurs will then help to find and fix bugs in the open-source code.

Link to story in The Economist

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Get Your Hands on a MikroScan – Check out Booth #638 at USCAP 2012

What’s your pain or pleasure?

The highly versatile MikroScan D2 whole slide scanner is touted as one of the most flexible instruments in the digital pathology communications market, and MikroScan wants a chance to prove it to you.

Help Shape the Future of Pathology Communications

MikroScan is requesting feedback directly from pathologists and researchers who know what they want in a slide scanner. What would you like to see at the MikroScan in-booth demo?

The company is requesting feedback from you directly. You can let them know in advance by clicking here.

Then you will have your chance to put them to the test live and in-person next week at USCAP.

Hands-on Demos at MikroScan Booth #638 at USCAP 2012

Bring your ideas and pain points and MikroScan will make it all better. MikroScan will be exhibiting in booth #638 at USCAP 2012 in Vancouver, BC, Canada. The growing slide scanner manufacturer will provide hands-on product demonstrations of its small-footprint desktop whole slide imaging platform for digital pathology along with their viewing components.

New Developments Announced at the Show

The company will also be highlighting several new developments including:

  • New cloud based service for slide image viewing, sharing and analysis
  • Live remote consults of extremely high quality images from anywhere over the Internet
  • New easy integrations with virtually all LIS platforms
  • Improved “ATM-simple” intuitive user interface

Don’t miss this opportunity for a hands-on demo of the most versatile and affordable whole slide scanner.

Plus, check back and make sure to read the blog before USCAP kicks off for exclusive news concerning MikroScan.

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New Version of Simagis Live Web Viewer

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New redesigned web viewer for Simagis Live clouds servers is now available. Among many design and usability improvements it features the following:

 

- Customizable branding

- Advanced annotations

- Dual image scale (pixels and physical units if available)

- Multi-touch support for viewing on Apple iOS devices such as iPad.

 

Live example: http://apps.simagis.com/live/public/7884b2cf-4dcf-4f52-94f0-62ee0f9185e0

 

This re-design effort is aimed to better serve the needs of imaging equipment manufacturers who include Simagis Live functionality under their own brand name in order to add cloud storage, web sharing and whole slide image analysis capabilities.

 

About Smart Imaging Technologies:

 

We provide cloud software, web applications and whole slide image analysis for Digital Pathology and Virtual Microscopy. To learn more visit http://web-pathology.net

 

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Visiopharm and Integrated Systems Engineering Announce Collaboration on a Platform for Data Management and Efficient Workflow in TMA based Research

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From TMA to Z: Visiopharm and Integrated Systems Engineering Announce Collaboration on a Platform for Data Management and Efficient Workflow in TMA based Research

The TMA software from Visiopharm, ArrayimagerTM, is now fully compatible with the Galileo TMA system from Integrated Systems Engineering

Visiopharm, a leader in Quantitative Digital Pathology, and Integrated Systems Engineering (ISENET) the manufacturer of the innovative Galileo TMA system, announce today a non-exclusive collaboration to promote a joint solution for data management, efficient workflows, and image analysis for Tissue Microarray based research.

Tissue Microarray (TMA) technology is a technical procedure that combines tens to hundreds of paraffin- embedded tissue specimens into a single paraffin block. The use of relatively small tissue cores, positioned onto a unique slide, allows simultaneous histological analysis of hundreds of samples. TMAs provide time and money saving benefits including:

? High throughput expression screenings
? Reduction of the number of slides to be mounted and analyzed
? Reduction of the amount of reagents and antibodies used
? Analysis of various biological specimens under uniform reaction conditions

? Saving of precious biological samples and possibility to re-use donor blocks

From start to finish the high quality construction, data management, and analysis of TMAs is essential. ISENET’s

Galileo TMA CK Family, was developed with an open architecture and designed for medical research and diagnostic applications. The open architecture of the Galileo TMA creates a perfect environment for client customizations including the use of different size blocks, and the use of the TMA as a picker which enables 96/384 well plates or Eppendorff vial holders to be used. The Galileo TMA system records core position and Donor ID within an electronic report (excel or xml file export suite); ensuring maximum traceability from Donor block, to TMA core, to TMA slide core. The Galileo TMA is CE marked for IVD applications and is covered with an National Cancer Institute (NCI) license for patent #US 6,699,710 B1 titled “Tumor Tissue Microarray for Rapid Molecular Profiling.”

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Digital pathology is a crucial part of an efficient TMA workflow. TMA glass slides can be scanned on any digital pathology scanning system to create whole slide images that are compatible with Visiopharm’s full suite of Cloud and Deployed analysis solutions. Visiopharm’s ArrayimagerTM automatically reads the electronic report from Galileo TMA system with the Block Design that is linking Donor ID and core position.

Slides are seamlessly imported into the Visiopharm database from all major slide databases, including essential metadata. ArrayimagerTM performs de-arraying and storing of all extracted cores in the fully searchable database, with clear identification of slide ID, and donor ID for each core. Researchers can search in any dimension, for donor ID, biomarker, results, etc, maintaining full traceability.

Michael Grunkin PhD, CEO of Visiopharm, stated “TMAs have grown in importance as a research tool since they were introduced by NIH, and have been widely applied in basic research on gene expression, biomarker discovery, references for tumor staging, and drug target validation. Recently we have even seen adoption of this approach for diagnostic purposes, and we believe that this is a growing trend. When it comes to commercial arrayers, there have only been a few very good choices. The Galileo instrument meets all the requirements we encounter in the market, when it comes to price, ease-of-use, precision, and quality. We are excited to be able to offer a fully integrated solution in collaboration with ISENET.”

TMA compatible APPs

Visiopharm’s patent pending APPCenter provides users with easy access to a growing library of over 30 ready-to- run APPs. All APPs are designed for whole slide and field-of-view images, and can be used for analysis of cores individually and for batch-processing of de-arrayed TMA cores.

There is no need to become an expert in image analysis; APPs are created for a wide range of biomarkers and validated in collaboration between experts in the field and Visiopharm’s application scientists and programmers. Custom APPs can be developed upon request, at a fixed known cost. Customers can try any APP free of charge, before investing, to make sure that 1) the APP is working according to specifications, 2) the APP provides useful results, and 3) the APP can be understood and operated. APPs are purchased for a low fixed cost, are yours to keep, and will work with both Visiopharm’s DeployedAnalysis and CloudAnalysis solutions.

Pasquale De Blasio, CEO of Integrated System Engineering, stated “TMAs require full traceability from Donor block to diagnosis. Visiopharm’s leading technology provides the essential data management and image analysis tools that the TMA community requires, and offers their solutions to users in an easy-to-use, flexible, and affordable way. Together, the collaboration between ISENET and Visiopharm will provide the research and diagnostic communities with a TMA solution focused on quality, data integrity and results.”

Visiopharm and ISENET will be exhibiting at the USCAP Annual Conference in Vancouver Canada on March 19-21, 2012. Come by and visit one of their booths, Visiopharm booth #730 and ISENET booth #521 to learn more about the advancement of Tissue Microarrays.

About Visiopharm

Over the past 10 years, Visiopharm image analysis and stereology software has become the preferred Quantitative Digital Pathology solution for leading biopharmaceutical companies, clinical researchers, and academic researchers all over the world. Visiopharm has more than 300 deployed systems worldwide and a large network of distribution and support partners, and is featured in over 400 scientific publications.

About Integrated Systems Engineering (ISENET)

ISENET was established in Italy in 1996. ISENET’s Galileo Tissue Microarrayer Family, with its open architecture, represents the most advanced TMA instrument on the market today for leading pathology researchers and biotech companies.

ISENET is a leader in Europe with more than 20 systems installed in key research institutes throughout Italy, Spain, Belgium, Brazil, Turkey, Czech Republic, and others. ISENET provides outstanding customer service, and promotes strong client relationships by providing customers with education, hardware customizations, and the design of specific applications. ISENET, in collaboration with BioSkills, also offers Tissue Microarray training courses to the scientific community. The next “Interactive Tissue Microarray Practical Course” is scheduled in Milan Italy on May 25th and 27th, 2012.

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DigiPath Adds Affordable Digital Hematology Solution

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DigiPath, Inc®, a provider of affordable, innovative and reliable digital pathology solutions, and Medica Corporation, a leading medical device designer and manufacturer with FDA and ISO compliant manufacturing facilities, have entered into a distribution agreement allowing DigiPath to assist their digital pathology customers in adopting EasyCell assistant, an affordable and FDA cleared digital hematology solution.

EasyCell assistant uses image-processing and pattern-recognition technology to automatically locate white cells on a blood smear, pre-classify the cells and then present them to a technician for review on an LCD display. EasyCell locates and pre-classifies normal white blood cells, smudge cells, NRBC’s and variant lymphocytes. Images of these cells are then displayed, grouped by cell type, for confirmatory review. 

“Our customers have been asking to augment their digital pathology deployments with automated hematology solutions,” said Eric Stoppenhagen, President of DigiPath,Inc.  “EasyCell assistant complements our existing affordable, innovative, and reliable solution portfolio.”

“DigiPath’s success in promoting digital pathology adoption will be extended by complementing their product offering with an affordable hematology solution.  I am delighted to have DigiPath as a distribution partner for EasyCell assistant,” stated Robert H. Hagopian, President of Medica Corporation.

About DigiPath, Inc.

DigiPath, Inc. provides the next generation of affordable, innovative, and reliable digital pathology solutions.  DigiPath’s advisors bring over 60 years combined expertise in pioneering digital pathology, implementing over 500 installations at community pathology practices, hospitals, academic medical centers, reference laboratories, biopharma organizations, and life science research institutions worldwide.

About Medica Corporation

For over 25 years, Medica has used its proprietary knowledge of sensor technology to manufacture a line of easy-to-use, easy-to-maintain, low-cost blood testing analyzers. Medica is actively engaged in the development of new technology to design future analyzers with the same ease-of-use. The Company’s rapid growth is a result of strategic focus on the worldwide need to lower healthcare costs.

SAFE HARBOR STATEMENT

This Press Release may contain certain forward-looking statements within the meaning of the Securities Litigation Reform Act of 1995. DigiPath has tried, whenever possible, to identify these forward-looking statements using words such as "anticipates," "believes," "estimates," "expects," "plans," "intends," "potential" and similar expressions. These statements reflect DigiPath's current beliefs and are based upon information currently available to it. Accordingly, such forward-looking statements involve known and unknown risks, uncertainties and other factors which could cause DigiPath's actual results, performance or achievements to differ materially from those expressed in or implied by such statements. DigiPath undertakes no obligation to update or provide advice in the event of any change, addition or alteration to the information catered in this Press Release including such forward-looking statements.

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Pathology day brings science to life at the Forum in Norwich

Norfolk and Norwich University Hospital senior biomedical scientist Ann Merryweather shows Eleanor Brolly(8) the method of blood transfusion during the Forum exhibition. Photo by Simon Finlay

By CHRIS HILL Saturday, March 17, 2012 4:47 PM

The life-saving science of pathology was explored during an education event at Norwichs Millennium Library.

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Although pathology is often associated with forensics and crime investigations, visitors to The Forum today were shown its role in diagnosing and treating a range of illnesses.

Children studied mocked-up samples in Petri dishes under microscopes, while cellular scientists explained how biopsies and body tissues could be studied to identify diseases and prescribe antibiotics.

Dr Caroline Barker, a consultant microbiologist at the Norfolk and Norwich University Hospital, said: Everybody thinks pathology is about what they see on TV in Silent Witness or CSI, but we are trying to show that it is integrally involved in diagnosing and treating diseases. It is not just about cutting up bodies and solving murders.

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Pathology day brings science to life at the Forum in Norwich

Visiopharm’s New APPCenter Rapidly Expands Their APP Library and Introduces a Customer Contributor Program

Visiopharm
Visiopharm’s rapidly expands the APPCenter and showcases over 30 APPs for cancer research, diabetes, neuroscience, respiratory, and much more. APPs are created and validated in collaboration between experts in the field and Visiopharm application scientists and programmers. Experts benefit from the collaboration through Visiopharm’s new customer Contributor Program. The Contributor Program offers customers of the APPCenter the ability to earn discounts. A 30% or 50% discount is offered, depending on the type of Contributor a customer become.

Visiopharm’s rapidly expands their Application Protocol Package (APP) library to over 30 APPs, available now in their patent pending APPCenter. The APPCenter provide customers with easy access to an extensive library of ready-to-run APPs for cancer research, diabetes, neuroscience, respiratory, and much more. Each APP includes detailed descriptions, references to scientific literature, illustrated examples, webinars, and more. There is no need to become an expert in image analysis; APPs are created and validated in collaboration between experts in the field and Visiopharm’s application scientists and programmers. Some of the new APPs featured in the APPCenter include:

Ki67+MART1, Double-IHC for Melanoma of Skin:1 This APP automatically detects and quantifies Ki67 positive cells within tumor regions. No manual outlining of the tumor is needed, since the tumor region is automatically identified based on the Ki67/MART1-IHC double staining. The protocol provides the number of positive nuclei within the tumor region as well as the ratio compared to the total number of nuclei within the tumor region.

CD56, IHC, uNK cells within Endometrium for Recurrent Miscarriage:1 Immunohistochemical analysis of endometrial tissue sections has demonstrated increased density of CD56+ CD16- uNK cells in the mid-luteal phase endometrium in women suffering from idiopathic recurrent miscarriage and recurrent implantation failure compared to fertile controls.2 This APP is designed to work on approx. 3 ?m sections of endometrial tissue immunostained with anti-CD56 monoclonal antibody and counterstained with Mayer’s haematoxylin. The APP measures the ratio of uNK cells among the stromal cells near the epithelial edge. Cells in the glands and in the epithelial edge itself do not contribute to the calculations. HER2, SISH for Breast Cancer: 1 The APP is based on the Visiopharm HER2 SISH algorithm, which by automated image analysis determines the HER2 amplification in brightfield digital images of breast cancer tissue sections stained by the INFORMTM HER2 Dual ISH assay from Ventana/Roche. This assay includes the HER2 Silver ISH (SISH) probe resulting in discrete or clustered small black signals, and the centromer 17 Fast Red ISH probe resulting in discrete red signals. The overall ratio of black to red signals constitutes the HER2 gene amplification.

Customers try an APP free of charge, before investing, to make sure that 1) the APP is working according to specifications, 2) the APP provides useful results, and 3) the APP can be understood and operated.

Become a Visiopharm Expert and Earn Discounts

Visiopharm’s new Contributor Program offers customers of the APPCenter the ability to earn discounts. A 30% or 50% discount is offered, depending on the type of Contributor a customer become. Our Contributor levels include:

  • Reference Contributor: When an already available public APP is purchased from the APPCenter, a discount of 30% is given when the customer agrees to become a reference for the APP. Specifically, the customer’s name and institution can be listed as a user of the APP.

  • Co-author Contributor: When a Custom APP is developed, a discount of 50 % is given if the APP can be made public in the APPCenter after the custom development is complete. Co-author Contributors would support the APP being made public by providing example images, and the information necessary to create the description of the APP.

    Michael Grunkin PhD, CEO of Visiopharm, stated “Quantitative digital pathology often is a new discipline to life-science researchers; many do not have any previous experience and exposure to this discipline. Our Contributor Program provides a platform where researchers can share their expert knowledge within their respective research fields and earn significant discounts. Contributors will help demonstrate and support how to answer important research questions, in a transparent way, using quantitative digital pathology. The program creates a simple, risk-free way in which other researchers can follow in their footsteps. Our Contributor program was designed to become a valuable resource to the research community, and to encourage and reward the sharing of knowledge, experiences, and visions.”

    APPs are purchased for a low fixed cost, are yours to keep, and will work with both Visiopharm’s Deployed Analysis and their new Cloud Analysis solutions. Custom APPs can be developed upon request, at a fixed known cost, and are also risk free with a complimentary trial. For more information on how to join the Contributor Program please visit Visiopharm’s new website at http://www.visiopharm.com or contact Visiopharm’s Professional Services department at proservices@visiopharm.com.

    About Visiopharm

    Over the past 10 years, Visiopharm image analysis and stereology software has become the preferred Quantitative Digital Pathology solution for leading biopharmaceutical companies, clinical researchers, and academic researchers all over the world. Visiopharm has more than 300 deployed systems worldwide and a large network of distribution and support partners, and is featured in over 400 scientific publications.

    1 For research use only
    2 Endometrial cell counts in recurrent miscarriage: a comparison of counting methods, Josephine A Drury, Helena Nik, Robbert H F van Oppenraaij, Ai-Wei Tang, Mark A Turner & Siobhan Quenby, Histopathology 2011, 59, 1156-1162, 4/2 - 2011

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An Entirely Automatic Method to Score Crypt Loss and Infiltration from Pathology Slides in a Mouse DSS Model of Colitis

This is a presentation by Cleopatra Kozlowski of Genentech at the Definiens Symposium in 2011 about using image analysis to score a mouse model of colitis. Much work has been done in the field of cancer biology and tumorigenesis but I think image analysis will prove increasingly important in non-neoplastic conditions such as inflammatory bowel disease (IBD) and neurodegenerative conditions. 

This video illustrates use of image analysis in IBD:

 

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Biopsy Sample Barcoding System Enhances Patient Safety at Beaumont

ROYAL OAK Beaumont Health Systems Anatomic Pathology laboratory has installed a touch screen workflow system to barcode, track and re-confirm the identity of every biopsy sample through every step in the laboratory process.

The VentanaVantage workflow system, by Ventana Medical Systems Inc. in Tucson, Ariz., helps to improve patient safety in the Anatomic Pathology lab so the right biopsy results are provided to the right patient as quickly as possible.

Beaumont is the first health system in Michigan with multiple hospitals connected together in a network on the Vantage platform. Beaumonts three hospitals collectively process 102,898 biopsy samples a year.

This new system allows us to have an integrated, unbroken chain of custody for biopsy samples, says Mark Kolins, Beaumont Health System chair, pathology and laboratory medicine. It eliminates data re-entry and reduces labeling errors because patient information is entered into a computer only once and electronically transferred with barcodescanners throughout the process. It also allows us to locate any specimen or slide on any workstation or instrument, to eliminate misplaced patient samples. As part of the implementation, Beaumont Anatomic Pathology staff worked with Ventana to review and simplify workflow processes for faster turnaround times and greater efficiency.

The system also provides a lab performance dashboard to help lab leaders identify opportunities for improvement in quality, safety and efficiency.

Previously, samples were manually labeled multiple times throughout the laboratory process, with a higher chance of an error.

In the Anatomic Pathology laboratory, patient biopsy samples removed through surgery are transformed into a section of tissue on a glass slide. Through a series of steps, the tissue is transferred to different media. A physician specializing in anatomic pathology examines the tissue using a microscope to determine at a cellular level if cancer or another disease is present.

In addition to the Anatomic Pathology lab, Beaumont uses barcodingas a patient safety measure for blood specimens in its clinical laboratories. Barcodelabels are produced at the point of collection for the 5 million inpatient blood tests processed annually in Beaumonts clinical labs. Beaumonts outpatient blood draw sites also use barcoding.

Beaumont is in the process of implementing a barcoding system for inpatient medication administration.

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Biopsy Sample Barcoding System Enhances Patient Safety at Beaumont

Amedisys Scores 19% Above National Average on Treatment Goals Met at Home

BATON ROUGE, La.--(BUSINESS WIRE)--

Amedisys, Inc. (NASDAQ: AMED - News) today announced it has proven clinical excellence with its Speech-Language Pathology (SLP) program, according to the American Speech-Language and Hearing Association (ASHA) National Outcomes Measurement System (NOMS) report for 2011.

Developed to illustrate the value of speech-language pathology services provided to people with swallowing disorders, cognitive and memory impairments, and communication disorders, NOMS is a data collection system, recognized by the Centers for Medicare and Medicaid Services (CMS). The key to NOMS is the use of ASHAs Functional Communication Measures (FCMs). FCMs are a series of disorder-specific seven-point rating scales, designed to describe the change in an individuals functional communication, swallowing, or cognitive/memory abilities over the course of treatment.

According to the 2011 NOMS data, Amedisys Speech-Language Pathology outcomes for treatment goals met in the home exceeded the national home care industry average by 19%. The national average for 2011 was 51.78% of treatment goals met in the home, while Amedisys met 70.87% of treatment goals.

We are extremely proud of our Speech-Language Pathology team here at Amedisys for achieving this level of high-quality care for our patients, said Jim Robinson, executive vice president of home health and hospice care for Amedisys. Our team of 600 speech-language pathologists, based in more than 300 Amedisys care centers across the country, work with thousands of patients each year to improve their communication skills and help with memory deficits. This specialized care often reduces the need for feeding tubes and helps patients recover the ability to swallow.

Swallowing disorders (also known as dysphagia) are diagnosed in approximately 10 million Americans each year. Nearly all dementia patients develop dysphagia, and swallowing disorders also are associated with stroke, respiratory conditions, brain and spinal cord injury, as well as progressive neurological conditions like multiple sclerosis, ALS and Parkinsons. People who suffer from swallowing disorders often experience weight loss, poor nutrition, dehydration, social isolation, choking and pneumonia.

In the last 10 years, the number of elderly Medicare beneficiaries who were admitted to the hospital for aspiration pneumonia increased by 93.8%, said David Hutchings, CCC-SLP.D., managing director of Rehab Services at Amedisys. Through our Speech Language Pathology program, our multidisciplinary care team takes a comprehensive approach in addressing dysphagia to help decrease the risk of aspiration pneumonia and hospitalizations for this condition.

To help those with swallowing disorders avoid health complications like pneumonia, Dr. Hutchings urges seniors and their loved ones to watch for, and talk to a health care professional about, the following symptoms:

By proactively treating swallowing disorders and using specialized feeding techniques that maintain nutritional needs, enhance safe food intake and maintain dignity for those on our home health and hospice service, we can help to reduce unnecessary hospitalizations, and improve peoples overall quality of life, Dr. Hutchings said.

For more information about NOMS, please visit: http://www.asha.org/members/research/noms/.

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Amedisys Scores 19% Above National Average on Treatment Goals Met at Home

This Week in Clinical Pathology

Bristol researchers report their clinicopathological and molecular assessment of 12 penile melanoma cases in the Journal of Clinical Pathology. The researchers examined the paraffin-embedded, formalin-fixed tumor tissue for KIT and BRAF mutations, which are common in other melanomas, but found no such mutations. As for the clinicopathological features, the researchers say that two-year and five-year survival was, respectively, 61 percent and 20 percent, which is a similar prognosis as other melanomas. "Penile melanomas are extremely rare and have a similar prognosis to melanomas elsewhere, but they often present late, leading to a poor outcome. The mutations seen in melanomas from other sites appear to be rarely present in these tumors," the Bristol team concludes.

Also in the Journal of Clinical Pathology, German researchers look at p53, p21, and cyclin D1 expression in 110 penile cancer cases. From this, the researchers found that p53 expression in the primary tumor is associated with a poor outcome, while p21 expression had a minor impact on survival and cyclin D1 had no association. "The possible prognostic implications of p21 seem to be complex and warrant further investigation," the team says.

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This Week in Clinical Pathology