Training the next generation of cancer nanomedicine scientists

PUBLIC RELEASE DATE:

18-Aug-2014

Contact: Casey Bayer c.bayer@neu.edu 617-373-2592 Northeastern University

Northeastern University has received a five-year, $1.15 million grant from the National Institutes of Health's National Cancer Institute to train the next generation of cancer nanomedicine scientists and clinicians through a unique experiential learning program.

The centerpiece of the new program, which is called "CaNCURE: Cancer Nanomedicine Co-ops for Undergraduate Research Experiences," is a unique partnership between Northeastern and the Initiative to Eliminate Cancer Disparities at the Dana-Farber/Harvard Cancer Center. The DF/HCC is the world's largest comprehensive cancer center, bringing together the research efforts of its seven member institutions, comprising Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital, Dana-Farber Cancer Institute, Harvard Medical School, and the Harvard School of Public Health. For more than a decade, the IECDamong the nation's first integrated, inter-institutional programs focused on eliminating cancer disparitieshas offered programming to address the complexities of cancer disparities, including training students, enhancing research, and facilitating access to underserved populations.

"Nanotechnology is leading to breakthroughs in diagnosis and therapy of many diseases, particularly cancer, leading to the new discipline of cancer nanomedicine," said principal investigator Srinivas Sridhar, Northeastern's Arts and Science Distinguished Professor of Physics, Bioengineering, and Chemical Engineering, and the director of the university's IGERT Nanomedicine Science and Technology program. "Advances in the field are beginning to have revolutionary impact on healthcare."

Over the next five years, a total of 75 undergraduate students will receive training to study and conduct cancer nanomedicine research in the laboratories of 35 leading scientists at Northeastern and DF/HCC. These six-month co-op experiences, facilitated through Northeastern's co-op office, will provide students in majors ranging from biomedical physics to chemical engineering with hands-on research experience and one-on-one mentoring from the leading researchers in cancer nanomedicine at these partner institutions.

"These mentors represent some of the world's best scientists in cancer nanomedicine research," Sridhar explained, noting that the undergraduate researchers will also have the opportunity to collaborate with their postdocs and graduate students. "We are tapping into an unprecedented resource of talent and expertise for teaching and the students' learning environment is going to be absolutely outstanding."

Sridhar, who expects to enroll the program's initial cohort of students this fall, has placed an emphasis on attracting young scientists from underrepresented minority groups. "Our goals are well aligned with that of NCI, which wants to ensure that segments of the population that are underrepresented in the scientific and healthcare professions have access to opportunities in research and professional development," he said.

All enrollees will participate in specialized workshops, conferences, and bi-monthly seminars featuring cancer nanomedicine experts. At the conclusion of the yearlong program, each student will give a presentation of his or her work.

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Training the next generation of cancer nanomedicine scientists

DGAP-News: MagForce AG: Successful final closing of a growth financing round for MagForce USA, Inc. under the lead of …

DGAP-News: MagForce AG / Key word(s): Private Equity MagForce AG: Successful final closing of a growth financing round for MagForce USA, Inc. under the lead of Mithril Capital Management

08.08.2014 / 14:00

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MagForce AG: Successful final closing of a growth financing round for MagForce USA, Inc. under the lead of Mithril Capital Management

Berlin, Germany, August 8th, 2014 - MagForce AG (Frankfurt, Entry Standard, XETRA: MF6, ISIN: DE000A0HGQF5), a leading medical device company in the field of nanomedicine focused on oncology, today announced that its subsidiary MagForce USA, Inc. has successfully closed its growth financing round. Mithril Capital Management, a growth-stage technology fund founded by Ajay Royan and Peter Thiel, led a group of strategic investors including the management in financing MagForce USA's growth round with proceeds of USD 15 million, with an option to increase the size of the round to USD 30 million. MagForce AG owns 77% of MagForce USA as of this closing. The strategic investors presently hold 23% of MagForce USA and may increase their ownership in future by exercising the warrants held by them. After all warrants are exercised, MagForce AG will continue to retain a majority ownership position in MagForce USA.

MagForce USA, Inc., has been granted a license by MagForce AG for the development and commercialization of NanoTherm(TM) Therapy for the treatment of brain and prostate cancers and will be responsible for developing the North American market (US, Mexico and Canada) for MagForce's technology and products. Under the prostate cancer license, MagForce USA will also receive royalties for the sale of NanoTherm(TM) particles for the treatment of prostate cancer outside North America.

Ben J. Lipps, Chairman and CEO of MagForce AG and also of MagForce USA, Inc., commented: "I am very optimistic about the US market, which has the largest potential especially for prostate cancer treatment. MagForce USA aims at developing its technology to offer a new focal treatment for Intermediate Stage Prostate Cancer with precise ablation of the cancer lesion while sparing normal tissue. In Mithril, we have found the right collaborator to support our expansion plans. Ajay Royan and Peter Thiel have proven themselves numerous times to be valuable partners in helping companies unlock long-term growth."

Ajay Royan, co-founder and managing general partner of Mithril, said: "Conventional treatments for prostate cancer have significant side effects and other limitations, while patients with glioblastoma currently have few good options at all. That's why MagForce's innovative approach to solid tumors is very promising and potientially important."

About MagForce AG and MagForce USA, Inc. MagForce AG, listed in the entry standard of the Frankfurt Stock Exchange (MF6, ISIN: DE000A0HGQF5), together with its subsidiary MagForce USA, Inc. is a leading medical device company in the field of nanomedicine focused on oncology. The Group's proprietary NanoTherm(TM) therapy enables the targeted treatment of solid tumors through the intratumoral generation of heat via activation of superparamagnetic nanoparticles. NanoTherm(TM), NanoPlan(R), and NanoActivator(R) are components of the therapy and have received EU-wide regulatory approval as medical devices for the treatment of brain tumors. MagForce, NanoTherm, NanoPlan, and NanoActivator are trademarks of MagForce AG in selected countries. For more information, please visit: http://www.magforce.com. Please learn more: video (You Tube)

About Mithril Capital Management Mithril is a global investment firm that provides capital to leading growth companies by partnering with teams who use technology to build transformative and durable businesses, often in industries long overdue for change. Each of these businesses is unique, but all face common challenges to unlocking long-term growth. Mithril helps navigate these critical inflection points by investing in size and with conviction. For more information, please visit: http://www.mithril.com

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DGAP-News: MagForce AG: Successful final closing of a growth financing round for MagForce USA, Inc. under the lead of ...

Researchers to track effects of revolutionary new medicines

PUBLIC RELEASE DATE:

4-Aug-2014

Contact: Jamie Brown jamie.brown@liverpool.ac.uk 44-151-794-2248 University of Liverpool

The University of Liverpool has been awarded 2 million to become a leading centre in the UK for tracking the fate in the body of materials used in breakthrough medicines.

Researchers will be using radioactive labelling to find out where key materials used in nanomedicines go once the medicines have entered the body.

Nanomedicines are a relatively new class of therapy which can deliver small quantities of a drug in a targeted way to the affected part of the body. Unlike traditional therapies, nanomedicines are formulated to use lower quantities, with the potential for cost savings, fewer side-effects and more rapid treatment of disease.

Part of nanomedicine formulations involve the use of polymers or other materials which help the drug reach its target, but until now there has been little research into where the carrier materials accumulate, despite them often making up over half of the mass of the medicine.

The Liverpool Radiomaterials Chemistry Laboratory at the University will 'tag' parts of the medicines by making some of them harmlessly radioactive and then monitor how they move around the body once drugs are administered. The process of making the polymers radioactive won't alter their chemical composition, so the nanomedicines can be studied pre-clinically without changing how they work.

Chemist, Professor Steve Rannard, said: "Nanomedicines have been used widely in cancer treatment where side-effects are often weighed against the short time span of treatment and the urgency of the condition.

"However they are now being increasingly studied for chronic conditions where treatment can go on for decades. This raises questions about where materials go and how they leave the body during long-term exposure."

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Researchers to track effects of revolutionary new medicines

In the Quest to Treat Intracerebral Hemorrhage, Nanomaterials Show Promise

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Newswise Intracerebral hemorrhage is a type of stroke that affects two million people worldwide each year. Despite its seriousness, no effective treatment has yet been developed. But if a recent study in the journal Nanomedicine is right, good news for doctors and patients might one day arrive in a very small package: namely, a peptide nanofiber scaffold. In the last few decades, molecular engineering of various self-assembling peptide nanofiber scaffolds (SAPNS) has emerged as an active area of research. The peptide can form stable structures that self-assemble into a gel-like substance.

Now a University of Hong Kong team led by Professor Raymond Tak Fai Cheung, PhD and his student Lynn Yan-Hua Sang, PhD, who performed the majority of the experimental work, suggests a new therapeutic strategy for intracerebral hemorrhage: injecting SAPNS directly into a hemorrhagic lesion. Using rats, the team found that SAPNS attenuated brain injury, reduced brain cavity volume and enhanced recovery of brain function. This is the first time a nanomaterial has been used to replace the hematoma in the deep brain in a rat model of intracerebral hemorrhage. The hemostatic effects of SAPNS and other self-assembling peptides were discovered by co-author Rutledge G. Ellis-Behnke, PhD, who advised Drs. Cheung and Sang.

One man with a keen interest in this result is Terrence W. Norchi, President and CEO of Arch Therapeutics, a Wellesley, MA-based medical device company that is exploring a potential alternative approach to traditional stasis and barrier applications, including stopping bleeding during surgery, after trauma and other applications. Arch Therapeutics is also the worldwide exclusive licensee of intellectual property owned by the Massachusetts Institute of Technology (MIT) and the University of Hong Kong (UHK), in which the composition of SAPNS is a cited agent for stopping bleeding. Dr. Ellis-Behnke, who performed his groundbreaking hemostasis research at MIT and UHK, is a co-founder of Arch Therapeutics.

Archs AC5 Surgical Hemostatic Device, currently in preclinical development, is also a peptide nanofiber scaffoldone that is being designed to achieve hemostasis in laparoscopic and open surgical procedures. It represents a new approach to the rapid cessation of bleeding and control of fluid leakage during surgery and trauma care. The time to hemostasis with this approach is measured typically in 15 to 30 seconds rather than several minutes as with existing solutions. It is also being designed to conform to irregular wound geometry, to allow for normal healing and to help maintain a clear field of vision in the wound area during the surgical procedure.

Because it is transparent and neither sticky nor glue-like, evidence supports that AC5 can be used in the laparoscopic or minimally invasive surgical setting. It consists of a synthetic peptide comprising naturally occurring amino acids that are not sourced from animals. When squirted or sprayed onto a wound, the clear, transparent liquid promptly intercalates into the nooks and crannies of the connective tissue where it self-assembles itself into a lattice-like gela physical structure that provides a barrier to leaking substances. It is being designed to quickly stop bleeding with rapid onset of hemostasis, and might also allow surgeons to safely operate through the resulting protective barrier. During the healing process, data supports that the underlying peptide is broken down into its constituent amino acids, then absorbed and either used in the amino acid pool of the body to build protein and muscle, or excreted in the urine.

Advances such as these point toward a future in which self-assembling peptides are a key tool for addressing some of the challenges faced by surgeons today.

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In the Quest to Treat Intracerebral Hemorrhage, Nanomaterials Show Promise

Shelton firms products in the pipeline could end diseases

A company specializing in the emerging field of nanomedicine has opened in Shelton, offering the possibility that major healthcare advances could be developed in the city.

U.S. Rep. Jim Himes cuts the ribbon at the new NanoViricides facility in Shelton while joined by company officials, including President and Chairman Anil R. Diwan, Interim Chief Financial Officer Meeta Vyas and Chief Executive Officer Eugene Seymour.

The products being produced here could very well end diseases such as influenza and dengue fever, U.S. Rep. Jim Himes said at this weeks opening of the NanoViricides Inc. facility on Controls Drive.

This is truly a game changer for humankind, Himes said.

He predicted the companys president and chairman, Anil R. Diwan, could even win the Nobel Prize in medicine if products now in development at NanoViricides succeed.

Diwan said the firm has six medicines in the pipeline that would treat the flu, dengue, HIV, herpes (cold sores) and eye viruses.

With money raised from investors, NanoViricides has bought the 18,000-square-foot building at 1 Controls Drive, near Long Hill Cross Road. The company is now moving its facilities and employees there from West Haven.

The Shelton site will include manufacturing areas, labs, research-and-development space and offices. The building offers a lot of room for expansion.

It will be the only nanomedicine clinical product manufacturing facility in Connecticut.

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Shelton firms products in the pipeline could end diseases

Nanobiotix revenue for the 2nd quarter of 2014

RegulatoryNews:

NANOBIOTIX (Paris:NANO) (Euronext: NANO ISIN: FR0011341205), a clinical-stage nanomedicine company pioneering novel approaches for the local treatment of cancer, today announces its revenue for the second quarter of 2014.

Income statement

Of which :

License Services

45,847 2,749

91,190 2,749

45,847 2,722

Activity

The revenue recorded by NANOBIOTIX during the second quarter of 2014 relates to the upfront payment (pro-rata share) from the Taiwan-based PharmaEngine within the framework of the licensing contract. This licensing contract was signed in August 2012 for the development and commercialization of Nanobiotixs lead product, NBTXR3 in the Asia-Pacific region. It is distributed using the straight-line method across the period between the date the contract was signed and the scheduled marketing launch in the region. This upfront payment totaled 810,640, generating a product of 45,847 for the period and totalling 91,190 for the first semester in 2014. The invoicing of services totalled 2,749 for the second quarter of 2014. In total, revenue for the second quarter amounts 48,596. Revenue for the first half of 2014 is 93,939 which is fully in line with Company expectations.

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Nanobiotix revenue for the 2nd quarter of 2014

Global Nanomedicine Market Projected to be Worth USD 177.60 billion by 2019

Albany, New York (PRWEB) July 04, 2014

The new title on Nanomedicine Market (Neurology, Cardiovascular, Anti-inflammatory, Anti-infective, and Oncology Applications) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019," predicts that the total nanomedicine market globally will be worth USD 177.60 billion by 2019, growing considerably from its 2012 value of USD 78.54 billion. This market is expected to achieve a compounded annual growth rate of 12.3% between 2013 and 2019.

Browse Nanomedicine Market Research Report with full TOC: http://www.transparencymarketresearch.com/nanomedicine-market.html.

The report talks about the major growth areas of within the nanomedicine market over the period of forecast. The introduction of new technologies and applications in this sector will propel growth to a significant degree at the global level. Further, the initiatives taken by various governments as well as privately-funded institutions towards promoting the commercialization of new nanomedicine products will boost this market. The report also dwells on the role played by the rising geriatric population base, the prevalence of medical needs that are in need of treatment, as well as the rising incidence of chronic diseases globally.

Make and inquiry: http://www.transparencymarketresearch.com/sample/sample.php?flag=S&rep_id=1753.

According to the report, the leading application segment within the nanomedicine market was that of oncology, holding a 38% share of the overall market in 2012, as a vast number of commercially available products prevail in this sector. The development of nanomedicine-based treatments and products that are able to directly target tumors in the brain and other bodily sites is poised to be a significant factor affecting growth in this market.

Though the largest market segment within the nanomedicine market is that of oncology, the fastest growing segment is the cardiovascular market. According to the Transparency Market Research report, growth in this segment has been fuelled by the presence of a sizeable patient population, and a simultaneous growth in the demand for device and drugs that are based on nanomedicine. These factors are collectively anticipated to further fuel the growth of the cardiovascular segment within the nanomedicine market.

Request for customization for this report: http://www.transparencymarketresearch.com/sample/sample.php?flag=S&rep_id=1753.

The report also carries out an in-depth analysis of the regional market share based on the applications, revenue, and products. According to the report, the nanomedicine market was largely dominated by North America in 2012. It is expected that this regional market will continue to hold its leading position in the way over the forecast period until 2019. Though the larger market share will be held by North America, it is anticipated that the fastest growing market, by region, will be Asia-Pacific. The report states that the CAGR recorded by the Asia-Pacific market will be 14.6% between 2013 and 2019.

Furthermore, the analysis of the regional markets also concludes that the Europe region is predicted to show a growth rate thats relatively higher than that of North America. Factors that are likely to cause this increased growth rate include: an improvement in the regulatory framework as well as the presence of a wide-ranging product portfolio in the pipeline, set to be introduced by leading market players.

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Global Nanomedicine Market Projected to be Worth USD 177.60 billion by 2019

Scientists engineer nanoparticles to prevent bone cancer, strengthen bones

PUBLIC RELEASE DATE:

30-Jun-2014

Contact: Marjorie Montemayor-Quellenberg mmontemayor-quellenberg@partners.org 617-534-6383 Brigham and Women's Hospital

Boston, MA A research collaboration between Brigham and Women's Hospital (BWH) and Dana-Farber Cancer Institute (DFCI) has utilized nanomedicine technologies to develop a drug-delivery system that can precisely target and attack cancer cells in the bone, as well as increase bone strength and volume to prevent bone cancer progression.

The study is published the week of June 30, 2014 in Proceedings of the National Academy of Sciences.

"Bone is a favorable microenvironment for the growth of cancer cells that migrate from tumors in distant organs of the body, such as breast, prostate and blood, during disease progression," said Archana Swami, PhD, BWH Laboratory of Nanomedicine and Biomaterials, co-lead study author. "We engineered and tested a bone-targeted nanoparticle system to selectively target the bone microenvironment and release a therapeutic drug in a spatiotemporally controlled manner, leading to bone microenvironment remodeling and prevention of disease progression."

"There are limited treatment options for bone cancers," added Michaela Reagan, PhD, DFCI Center for Hematologic Oncology, co-lead study author. "Our engineered targeted therapies manipulate the tumor cells in the bone and the surrounding microenvironment to effectively prevent cancer from spreading in bone with minimal off-target effects."

The scientists developed stealth nanoparticles made of a combination of clinically validated biodegradable polymers and alendronate, a clinically validated therapeutic agent, which belongs to the bisphosphonate class of drugs. Bisphosphonates bind to calcium. The largest store of calcium in the human body is in bones, so bisphosphonates accumulate in high concentration in bones.

By decorating the surface of the nanoparticles with alendronate, the nanoparticles could home to bone tissue to deliver drugs that are encapsulated within the nanoparticles and kill tumor cells, as well as stimulate healthy bone tissue growth. Furthermore, bisphosphonates are commonly utilized during the treatment course of cancers with bone metastasis, and thus alendronate plays a dual role in the context of these targeted nanoparticles.

The scientists tested their drug-toting nanoparticles in mice with multiple myeloma, a type of bone cancer. The mice were first pre-treated with nanoparticles loaded with the anti-cancer drug, bortezomib, before being injected with myeloma cells. The treatment resulted in slower myeloma growth and prolonged survival. Moreover, the researchers also observed that bortezomib, as a pre-treatment regimen, changed the make-up of bone, enhancing its strength and volume.

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Scientists engineer nanoparticles to prevent bone cancer, strengthen bones

Global Nanomedicine Market: Industry Analysis, Size, Share,Growth, Trends, and Forecast 2013 – 2019

Albany, New York (PRWEB) June 30, 2014

This report includes market estimations for nanomedicine market for the forecast period 2013 2019. The nanomedicine market size is represented in terms of USD billion, and the market estimates and forecasts are calculated considering 2012 as the base year. Moreover, the trends and recent developments of the nanomedicine market have been kept into account while forecasting the market growth and revenue for the period 2013 2019.

Browse the full Nanomedicine Market Report: http://www.transparencymarketresearch.com/nanomedicine-market.html

The overall nanomedicine market is segmented on the basis of applications and geography, and the market estimations for each of these segments, in terms of USD billion, is provided in this report.

The nanomedicine market, on the basis of applications, is segmented into neurological, cardiovascular, oncology, anti-inflammatory, anti-infective and other markets. The nanomedicine market is also estimated and analyzed on the basis of geographic regions such as North America, Europe, Asia-Pacific and the rest of the world. The global trends such as drivers, restraints, and opportunities of the global nanomedicine market is detailed in the market overview chapter of this report, with a view on impact of these factors on market growth along the course of the forecast period.

For further inquiries, ask here: http://www.transparencymarketresearch.com/sample/sample.php?flag=S&rep_id=1753

The chapter on competitive landscape consists of heat map analysis of the key players operating in the global nanomedicine market. Some of the key players of this market include GE Healthcare, Mallinckrodt plc, Nanosphere Inc., Pfizer Inc., Merck & Co Inc., Celgene Corporation, CombiMatrix Corporation, Abbott Laboratories and others. The role of these market players in the global nanomedicine market is analyzed by profiling them on the basis of attributes such as company overview, financial overview, product portfolio, business strategies, and recent developments.

The global nanomedicine market is categorized into the following segments:

Nanomedicine Market by Application

Nanomedicine Market by Geography

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Global Nanomedicine Market: Industry Analysis, Size, Share,Growth, Trends, and Forecast 2013 - 2019

Challenging the Old Order to Set New Frontiers in Nanoscience & Nanotechnology

Los Angeles, CA (PRWEB) June 19, 2014

Several prominent speakers from across the globe that are part of Nanotek-2014 include Claudio Nicolini, Nanoworld Institute, Italy; Haruo Sugi, Teikyo University School of Medicine, Japan; Jim Klostergaard, MD Anderson Cancer Center, The University of Texas, USA; Israel Felner, The Hebrew University, Israel; Jean-Paul (Moshe) Lellouche, Bar-Ilan University, Israel; John F. Donegan, Trinity College Dublin, Ireland; Ashok K. Vaseashta, International Clean Water Institute, USA,; Kimihisa Yamamoto, Tokyo Institute of Technology, Japan; Serhii Shafraniuk, Northwestern University, USA; Mark Kester, NanoSTAR Institute of the University of Virginia, USA; Bjarne Bogen, University of Oslo and Oslo University Hospital, Norway; and Moinuddin Sarker, Natural State Research, Inc., USA.

Eminent Nobel Laureate Prof. Harold Kroto of the Florida State University, USA delivers keynote address on 'Carbon in Nano and Outer Space. On this occasion he described Nanotek-2014 as "Recent and exciting developments in our understanding of nanostructured materials promise paradigm shifting advances in device applications.Meetings such as Nanotek 2014 facilitate the cross-disciplinary research which will be needed to overcome the major technical hurdles if this promise is to be realized."

OMICS Group Journal of Nanomedicine & Nanotechnology, Journal of Nanomedicine & Biotherapeutic Discovery and Journal of Nanomaterials & Molecular Nanotechnology supports the OMICS Group Internationals Nanotek-2014 by publishing all the accepted and presented abstracts as proceeings.

This international conference will focus on many interesting scientific sessions such as Nanomaterials, Nanostructures, Nanomedicine, Nanodevices and Nanosensors, Materials science and Engineering, Nanoelectronics, Nanotechnology in Energy Systems, Environment, Health and Safety Issues of Nanotechnology, Recent Trends in Nanotechnology, Applications of Nanotechnology, Biomedical Engineering and Applications.

Two pre-conference National Symposiums has been scheduled during Nanotek-2014. Prof. Claudio Nicolini from The Fondazione Elba-Nicolini, Italy is organizing a pre-conference workshop on Structural Nanoproteomics, Dr. Dominique Ausserr, University of Le Mans, France, is organizing a pre-conference workshop on Coupled optical and electrochemical monitoring of working eletrodes in electochemistry research and Prof. Ashok K. Vaseashta from International Clean Water Institution, USA organizes a workshop on NT4W-Nanotechnology for Water Generation, Contamination Detection and Purification.

Asia pacific based Asian News Channel that provides 24/7 News & Feature service for Asia Pacific and Africa Region acts as a collaborator for this scientific event, while American Elements, a global manufacturer of several Nano-material including nanoparticles, nanopowder, nanotubes, nanowire, quantum dots, submicron, -325 mesh, etc., and The PlasmaChem mainly concerns nano-materials, detonation, vacuum, plasma and ultra-thin film technologies and their biomedical and technical applications. Sponsors the advertisements.

OMICS Group International is an open access publisher that publishes 400, Peer Reviewed Journals in the fields of Clinical, Medical, Engineering and technological, Pharmaceutical and Management fields. OMICS group hosts more than 300 International conferences and events across the globe. With the help of more than 150 scientific associations. Besides this OMICS Group also encourages the business collaboration and interaction through its B2B and Scientific Meetings.On behalf of Nanotek-2014, OMICS Group is glad to invite contributions from the enthusiastic participants to organize International Workshops that are both empirical and conceptual in exploring new dimensions in this field. It is open to all types of research methodologies both from academia and industry.

For conference registration / sponsorship application and additional details about Nanotek-2014, visit http://nanotechnology2014.conferenceseries.net/

Or contact

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Challenging the Old Order to Set New Frontiers in Nanoscience & Nanotechnology

No More Eye Drops for Glaucoma

Scientists from Nanyang Technological University in Singapore and the Singapore Eye Research Institute have jointly developed a new nanomedicine, liposomal latanoprost, that will allow glaucoma patients to do away with daily eye drops. The nanomedicine is delivered to the front of the eye via a painless injection and will stay and release the anti-glaucoma drugs slowly over the next six months.

Glaucoma is a leading cause of blindness, especially for the elderly. The condition is caused by high intra-ocular pressure in the eye, which then leads to damage to the optic nerve. Conventionally the first line of treatment for glaucoma patients is the daily application of eye drops that can lower the high pressure in their eyes. This treatment is usually required for the rest of the patients' lives because glaucoma is a chronic disease. The sustained-release drug therapy can provide months of control for glaucoma patients with a single application, compared to just hours with eye drops.

The new therapy has successfully gone through a pilot study with six patients conducted at the Singapore National Eye Centre. The treatment was shown to be both safe and effective.

Co-lead scientist Associate Professor Tina Wong, who is the head of the Ocular Therapeutics and Drug Delivery Research Group at the Singapore Eye Research Institute, said the new nanomedicine will benefit the elderly who often forget to use the daily eye drops, a lapse that leads to the worsening of their condition.

A release from the university quotes Dr. Wongs as saying, "It is estimated that at least ten per cent of blindness from glaucoma is directly caused by poor patient adherence to their prescribed medications. Many patients find it difficult to adhere to their doctor's prescribed regime for many reasons, such as forgetfulness, finding it too troublesome, or they lack understanding of the disease. The results in this clinical study will open up a new treatment modality for glaucoma other than taking daily eye drops, and will greatly enhance patient compliance and improve treatment outcomes."

Professor Subbu Venkatraman, Prof Wong's research partner, notes that the successful study of liposomal latanoprost can be hailed one of Singapore's early successes in the emerging area of nano medicine.

" This is the first nanocarrier-drug combination that shows therapeutic effects for three to four months with a single dose. The tough challenges we faced were to make this nanocapsule stable and biocompatible, while at the same time controlling the release of the drug at the desired rate over months," added Prof Venkatraman, the founding director of the NTU-Northwestern Institute for Nanomedicine, she said,

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No More Eye Drops for Glaucoma

Cancer Nanomedicine – The Cancer Nanomedicine Blog

The field of nanomedicine is inherently multidisciplinary requiring the involvement of those with knowledge of engineering, physics, chemistry, biology as well as medicine. The commercialization of nanomedicine adds further complexity and requires additional participation from those with experience in manufacturing, intellectual property, regulatory issues, strategic partnering, and raising investment. Suffice it to say, getting a nanomedicine to the clinic is a tremendous challenge. Given that nanomedicine is still a fairly nascent area, most nanomedicines are currently being developed in academia.

The Wyss Institute at Harvard University

The Wyss Institute at Harvard University is a collaborative effort between researchers, clinicians, corporations, and startups. The Institute is partnership between the following entities:

Programmable, or smart, nanomaterials can be formed from numerous types of materials including metals, polymers, and ceramics. At the Wyss Institute, nucleic acids (RNA, DNA) are the building blocks of their programmable nanomaterials. Nucleic acid-based nanostructures such as DNA origami are being developed to enable multiplexed diagnostic assays and medical imaging techniques and to form nanoparticle drug carriers targeting diseased sites within the body.

Heres a video from the Wyss Institutes website discussing DNA-based programmable nanomaterials.

To facilitate the launch of new ideas that may transcend into potential medical solutions, the Wyss Institute offers small grants to faculty at Harvard and collaborating academic institutions and medical centers. These grants enable exploratory research that would otherwise be too early-stage for government or industry funding. These early-stage grants are a much-needed source of financing as early-stage funding is extremely challenging to obtain, especially for life sciences efforts.

At the other end of the spectrum of commercialization, complementary to seed grants, the Wyss Institute actively seeks industrial partnerships. These partnerships can help with not only providing additional funding to promising projects, but also in giving insight to researchers regarding market opportunities. The industrial partners are also potential licensees of technologies developed at the Wyss institute, helping to bring the ideas to fruition and eventual commercialization.

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Cancer Nanomedicine - The Cancer Nanomedicine Blog

New glaucoma treatment replaces the hassle of applying eyedrops daily

SINGAPORE - Under the treatment, a drug contained in millions of tiny capsules is injected into the eyeball. These nanomedicine capsules slowly release their contents over six months, replacing the need for daily eyedrops.

Get the full story from The Straits Times.

Here is the statement from the Nanyang Technological University:

Scientists from Nanyang Technological University (NTU) and the Singapore Eye Research Institute (SERI) have jointly developed a new nanomedicine that will allow glaucoma patients to do away with daily eye drops.

Glaucoma is a disease which could lead to blindness. This new sustained-release drug therapy can provide months of relief to glaucoma patients with a single application, compared to just hours with today's conventional eye drops.

The new therapy has successfully gone through a pilot study with six patients conducted at the Singapore National Eye Centre and has yielded exceptional results, having shown to be both safe and effective in the treatment of glaucoma.

A leading cause of blindness in the world especially for the elderly, glaucoma is caused by high intra-ocular pressure in the eye which then leads to damage to the optic nerve. Conventionally, the first line of treatment for glaucoma patients is the daily application of eye drops which can lower the high pressure in their eyes. This treatment is usually required for the rest of the patients' lives as glaucoma is a chronic disease.

Co-lead scientist Associate Professor Tina Wong, who is the head of the Ocular Therapeutics and Drug Delivery Research Group at the Singapore Eye Research Institute, said the new nanomedicine will benefit the elderly, as they often forget to use the daily eye drops, leading to the worsening of their conditions.

"It is estimated that at least ten per cent of blindness from glaucoma is directly caused by poor patient adherence to their prescribed medications," says Dr Wong, an Adjunct Associate Professor with NTU's School of Materials Science and Engineering.

"Many patients find it difficult to adhere to their doctor's prescribed regime for many reasons, such as forgetfulness, finding it too troublesome, or they lack understanding of the disease. The results in this clinical study will open up a new treatment modality for glaucoma other than taking daily eye drops, and will greatly enhance patient compliance and improve treatment outcomes," she said. Professor Tina Wong is also a senior consultant ophthalmologist with the Glaucoma Service at Singapore National Eye Centre.

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New glaucoma treatment replaces the hassle of applying eyedrops daily