CHECK AND BALANCE. European double-board certified in Nutritional Medicine and Anti-Aging Medicine Dr. Ted Achacoso of BioBalance with microbiota expert Dr. Peter Konturek at the recent 4th World Congress on Targeting Microbiota in Paris, France.

Recent years have seen fecal transplant, or formally Fecal Microbiota Transplantation (FMT), becoming an emerging procedure in the medical field, which basically involves transferring a healthy individuals gut bacteria into a sick persons colon. This may sound surprising to some, but more and more studies reveal the role of gut microbesincluding those in human wastein treating various health conditions, from gastrointestinal problems (ulcers, irritable bowel syndrome, etc.) to non-gastrointestinal diseases such as diabetes, liver disease, allergies, obesity, and autoimmune diseases, among many others. Simply put, a healthy gut is revealed to play a role in both the cure and prevention of such diseases, making the demand for the FMT and other advanced gut health diagnostics and treatment surge across the world in the past two years.

The emerging science of gut health

Addressing gut health for disease prevention and optimization makes sense with the understanding that the gut makes up 70 percent of our immune system. Its thousands of diverse bacterial species are responsible for deciding which substances we consume or gets into our body will be absorbed or secretedprotecting us from infection and regulating our metabolism. A leaky gut would have fewer strains of good bacteria to do such a job, thus the current popularity of FMTs. Today, we can already look into a persons overall gut health and clearly see if there are bad bacteria in your gut or if you lack good bacteria in it that causes you to get sick, become obese, and more, says Dr. Ted Achacoso, a prodigy doctor who isEuropean double-board certified in Nutritional Medicine and Anti-Aging Medicineand heads BioBalance Wellness Institute in the Philippines.The state of your gut says so many things about your entire body.

How the gut influences mood, immunity, aging

Approximately, up to 100 trillion microorganisms per human body colonize the intestinal tract making an additional acquired organ that provides many vital functions to the host. A healthy gut microbiome can be defined by the presence of the various classes of microbes that enhance metabolism, resistance to infection and inflammation, prevention against cancer and autoimmunity, and that positively influence so called brain-gut axis, states a study in the Journal of Physiology and Pharmacology 2015 co-authored by Dr. Peter Konturek, considered the worlds most prominent microbiota expert. The study further discusses the correlation of gut health to peoples behaviors, moods, and aging, among others, only putting more emphasis on the importance of a healthy gut.

Bringing to Manila the worlds expert on gut health

Dr. Peter Konturek, the worlds expert on gut health and FMT, has been thriving as a Professor of Internal Medicine and Gastroenterology at the University Erlangen-Nuremberg in Germany and the Head of the Department of Internal Medicine at the Thuringia Clinic Saalfeld. BioBalance Wellness Institute, a major proponent of health optimization and gut health in the Philippines, is bringing Dr. Konturek to Manila this month for a medical lecture. The lecture intends to impart knowledge on scientific advances on the gut microbiotas influence on health and disease in the hope of expanding the knowledge and influence enthusiasm among medical practitioners and patients. BioBalance has been offering its clients intensive and advance gastro-intestinal and nutritional diagnostics since its inception, making the institute the perfect partner for Dr. Konturek in the Philippines.

Part of Dr. Kontureks lectures in Manila on March 14 will include scientific advances and perspectives on the gut microbiotas influence on peoples brain, mood, immunity, aging, and diseases; a special session on FMT, and practical gut health protocols. Having published over 250 original peer-reviewed publications and more than 15 book chapters, Dr. Kontureks researches are focused on the impact of H.pylori infection in the pathogenesis of peptic ulcer disease and gastric cancer, pathogenesis of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), and the role of microbiota in the gastrointestinal tract and interaction with the brain-gut-axis, among others.

Dr. Peter Kontureks medical lecture titled The Investigational New Drug in Your Gut: Advances in Gut Microbiota Science and Fecal Microbiota Transplant Therapy will be held on March 14, 2017 (Tuesday), from 6 to 9 p.m., at JY Halls A & B, Bayanihan Center, Unilab. For more information and seat reservation, please contact BioBalance Institute at (02) 650-4858 or (0917) 521-4860, or e-mailinfo@biobalanceinstitute.com. Limited seats are available.

ADVT

Continued here:
Gut Microbiota Therapy: the next big thing in Medical Treatments - Inquirer.net

Posted on March 2, 2017, 6 a.m. in Biotechnology Drug Delivery Technology

Researchers develop the first DNA computer capable of pinpointing several antibodies in the blood and carrying through resultant calculations.

A team of researchers has developed an intelligent DNA computer that can enable controlled drug delivery into the bloodstream. The team, from Eindhoven University of Technology in the Netherlands, believes this new method will lead to the development of smart drugs that more effectively treat autoimmune diseases like rheumatoid arthritis and Crohn's disease. The team, led by Professor of Biochemical Chemistry Maarten Merkx, published their findings in the Nature Communications journal.

DNA Computing

DNA computing is a largely experimental field of scientific study. Using a combination of DNA, biochemistry, and molecular biology hardware, researchers seek to use DNA sequencing for data storage and to perform complex calculations.

The goal of this new field is to create nano-computers using DNA instead of mechanical parts. The resulting machines would be able to store immense amounts of data and make complex calculations faster than inorganic equipment. Some scientists believe DNA computers may one day replace silicon-based hardware.

Possible Applications in Medical Treatment

DNA computing methods, due to their organic nature, allow medicines to work more effectively with the bodys natural defenses. Researchers compare the body to a security system with facial recognition. Previous research has focused on creating a machine that is recognized by the body, similar to the way a security system would recognize an authorized person.

Professor Merkxs method adds the ability to recognize the presence of antibodies. The identification and measurement of antibodies is a crucial step in diagnosing and treating disease. Antibody levels are also a factor when calculating the dosage of therapeutic drugs.

With DNA nano-computers able to detect and measure antibodies while performing complex analyses, researchers are hopeful machines can be programmed to carry out actions in response to certain measurements. Merkxs team successfully used DNA computing to control the activity of enzymes. The professor believes it is possible to apply this technique to therapeutic antibodies. This should result in better absorption of therapeutic substances. When used as a delivery system, these computers will be able to decide how much medicine to release into the bloodstream, based on the antibodies in the bloodstream.

Future Applications in the Treatment of Chronic Disease

Researchers are working on ways to use the technology in the fight against chronic diseases like rheumatoid arthritis and Crohns Disease. These conditions are often treated with the same drugs. The dosage is dependent on the condition it is meant to treat. Smart drugs would be able to deliver the most accurately therapeutic dose of medication. This would allow for more effective treatment. It would also reduce the overall cost of treatment and reduce side effects.

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DNA Computer Enables Controlled Drug Delivery - Anti Aging News

You've often heard the phrase," if you don't have your health, you don't have anything."

So many wonderful businesses have opened in the past few years allowing us to keep our health in check, our bodies toned, our minds clear, and our skin as good as it can be as we continue to age.

It's not easy getting older and we all get there no matter what we do to try to stave it off. Following are a few of the great businesses we recommend to keep you on the path to feeling great and looking good:

ForeverYoungMDSpa is owned by Dr. Gail Krivan, M.D. who has made it her passion to help all look as good as possible, no matter the age. Whether it's a simple injectable to smooth out wrinkles or a full resurfacing of the skin, Dr. Krivan has a whole bag of wonderful "tricks" that will keep you looking your very youthful best. 461-0535.

Dr. Frank Shallenberger is a well-known anti-aging guru who heads the Nevada Center of Alternative & Anti-Aging Medicine. He has helped many through the difficult menopausal stage and other ailments using orthomolecular medicine versus allopathic medicine cures. He is an M.D. who has written books on his revolutionary new approach to health, aging and disease prevention. 884-3990

Paradise Salon-Spa-Wellness can take care of just about every need from aquatic exercises in their beautiful therapy pool to taking care of every part of your body from head to foot. The staff subscribes to the old adage, "when you look marvelous, you feel marvelous!" 883-4434

Kaia FIT & Tumbleweeds Gymnastics is a women's only fitness center with the mission to create strong bodies and powerful minds and provide nutrition advise to last a lifetime. 841-4962

Pulse Fitness in Minden offers a bit of everything. Zumba, Yoga, RIPPED, Chisel'd, TRX, Karate, Spin and more as well as all the things you would expect from a fitness center. They offer a 3-day VIP pass so you can try them out. Conveniently located near the Carson Valley Swim Center 782-2705.

The Change Place is Carson City's newest wellness center offering personal training, yoga, massage and motivational therapists. It's a unique total wellness center where you can enjoy music and art. Drop-in encouraged. 283-0699.

Sierra Nevada Holistic Services is all about integrated wellness through massage, meditation, energy work, aroma therapy, and cold laser therapy to relieve pain. 720-2563

Keep your skin in great shape!

Felicity Skin Full Esthetician services 843-9316

May Kay Cosmetics Carol Swanson 267-0418

Mary's About Face & Body Full skin care including body wraps 841-5969

Massages make you feel great inside and out:

Massage Envy 267-9400

Sierra Nevada Holistic Services, LLC 720-2563

The Change Place 283-0699

Touch of Bliss 291-9577

Link:
Feeling good and looking great - Nevada Appeal

Mount Tam With Anti-Aging Drug Is Secretly Preparing For Trump's New FDA ValueWalk In spite of this, medicine is still based on the old disease model. Doctors wait for a disease to appear and then treat it. Regulators approve drugs to help treat full-blown diseases. This needs to change. But the move from a disease cure to a disease ...

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Mount Tam With Anti-Aging Drug Is Secretly Preparing For Trump's New FDA - ValueWalk

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The biostation is a comprehensive, individualized, scientific approach to total wellness and age management for men and women looking to rejuvenate their bodies, revitalize their minds and reclaim their confidence. From cosmetic enhancements that help you glow on the outside, to the latest advances in natural healthcare that transform your body from the inside, the biostation will customize a targeted treatment plan designed to get you the results you want.

Having opened its second location on Miami Beach at 777 Arthur Godfrey Road Suite 330, the newest biostation will follow in its Delray Beach flagship footsteps, maintaining the essence of the practice and offering a full range of total wellness and anti-aging services to all of South Florida. The medical center is elegant and spa-like, providing a unique experience to each and every patient. Dedicated Patient Advocates and in-depth personal consultations with their in house Medical Directors, Dr. Bloom and Dr. Shapiro, ensure an exceptional patient-centric experience.

Miami Beach Medical Director, Dr. Jason A. Shapiro, and the biostation Co-Founder, Dr. Martin G. Bloom, have combined their extensive expertise in Medical Aesthetics and Functional Medicine to provide cutting edge total wellness and aesthetic enhancement services designed to help patients beautify and age defy from the inside out.

Dr. Shapiro is a renowned physician Board Certified in Internal Medicine, whose extensive aesthetics training has allowed him to provide his patients with safe, effective, and above all, natural-looking non-surgical and surgical procedures using the most advanced equipment and techniques. Dr. Bloom, a cardiologist of 35 years, decided to embark on his journey in Functional Medicine 5 years ago with the goal of reaching patients earlier in the aging process and providing them with the personal attention and care they deserve. In 2015, Dr. Shapiro partnered with the biostation and Dr. Bloom to expand his highly successful aesthetics practice to include total wellness, anti-aging and medical weight loss services.

The biostation total wellness and anti-aging services:

Comprehensive blood panel, food & allergy testing Hormone Replacement Therapy Nutrient Therapy IV Therapy Medical Weight Loss Platelet Rich Plasma Sexual Health Hair Restoration Lips by Shapiro Botox Dermal Fillers Facial Aesthetics Liposuction & Laser Lipo Kybella Laser Tatoo Removal Surgical Aesthetics

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Miami Beach's Newest Wellness Institution biostation - Miami's Community Newspapers

Question: What is carboxytherapy?

Answer: Carboxytherapy is a treatment that uses carbon dioxide in controlled doses to treat a number of aesthetic conditions. It was first discovered in 1946 in France, when physicians noticed that patients with circulation problems improved in the carbon dioxide-rich thermal waters of Royat.

The indications for this therapy have extended since then from treating medical problems to its application in aesthetic medicine as an effective treatment for stretch marks, cellulite, localized fat deposits, scars, hair loss, improvement of skin laxity, wrinkles and dark circle under the eyes.

Carbon dioxide is a naturally occurring gas that the body produces as a byproduct of respiration and cellular metabolism. As such, it is safe to use; in fact, it is used extensively in medicine every day, such as in colonoscopies and laparoscopic surgery. Carbone dioxide has no toxicity even in elevated doses.

As a result of aging, we may have decreased blood flow and oxygen delivery to the tissues. When carbon dioxide is injected into the treated area, your body detects a lack of oxygen in that area and reacts by dilating your capillaries, thereby improving blood flow and oxygen delivery. This stimulates fat cell and scar tissue breakdown, while simultaneously increasing collagen production. The procedure uses a small needle to infuse the carbon dioxide gas under the skin. It usually requires a series of treatments for optimal results and there is no downtime. For more information visitwww.drdadurian.com or call 561-655-6325 for a complimentary consultation.

Daniela Dadurian, M.D., specializes in anti-aging medicine and is an expert in non-surgical body-contouring techniques. She received her medical degree from the University of Miami School of Medicine and has traveled the world researching the safest and latest technologies on the market.

______________________________________

MD Beauty Labs Medical Spa and Wellness Center

320 S. Quadrille Blvd. West Palm Beach

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Learn more about carboxytherapy - Palm Beach Post

CHICAGO, Feb. 21, 2017 /PRNewswire/ -- In physics the search goes on to find the one unified theory of how all forces in the universe originate from a single field, a single unifying force. Einstein sought after the "theory of everything" until his death but never found it. What if there is a grand unified theory of how all disease begins? Dr. Keith Nemec, the director of Total Health Institute, an alternative and integrative medical facility in Chicago and a graduate of University of South Florida's Morsani College of Medicine, believes that this unifying cause of all disease is inflammation at the cellular level.

Dr. Nemec has begun his preparatory Ph.D. research in Metabolic and Nutritional Medicine focusing on the underlying cause of health and disease. According to Dr. Nemec, "All disease starts with cellular inflammation. Whether you have cancer, heart disease, diabetes, digestive disorders, autoimmune disease or Alzheimer's, it all starts with inflammation at the cellular level which leads to either early cell death translating into specific organ or gland disease or into cancer stem cell stimulation which fuels cancer cell growth and metastasis."

Dr. Nemec explains that disease cannot be resolved by looking at the disease and trying to cure it, but by looking at the environment that allows all disease to form and changing that instead. According to Dr. Nemec, "If you put garbage on your driveway it will attract flies. If you want to get rid of the flies how many cans of insecticide will you need? The answer is infinite because no matter how many flies you kill more will come because you have an environment (the garbage) that enables them to grow. When you change the environment (get rid of the garbage) the flies will be gone and so will the disease, all disease."

Dr. Nemec states, "All cells need four basic elements to live and thrive. Oxygen in, water in, food in and waste products out. If these are done on a timely basis the cells will live very long. The human body was designed by God to live well over a hundred years in health but this can only be achieved when these four elements are efficiently maintained. If there is a breakdown of any of these four at the cellular level, this is when inflammation, the precursor to all disease, begins."

Dr. Nemec's vision is catching on as people are traveling from around the globe to Total Health Institute to change their cellular environment with the Institute's treatment and teaching programs.

Dr. Nemec is an author, and lecturer in the field of diet and nutritional medicine. Dr. Nemec is a board-certified diplomate of American Board of Anti-Aging Health Practitioners. This is a certification program of the American Academy of Anti-Aging Medicine. Dr. Keith Nemec also holds his fellowship in Integrative Cancer Therapy through American Academy of Anti-Aging Medicine.

Dr. Nemec can be contacted through the Total Health Institute's website totalhealthinstitute.com.

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/leading-integrative-medicine-institute-reveals-the-single-unifying-cause-of-all-disease-300410468.html

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Leading Integrative Medicine Institute Reveals the Single Unifying ... - Yahoo Finance

HALLANDALE, Fla., Feb. 24, 2017 /PRNewswire/ --KRISTAN WEINSTEIN-ANP-BC IS RECOGNIZED AS A GRADUATE OF THE INSTITUTE FOR FUNCTIONAL MEDICINE'S CERTIFICATION PROGRAM by A4M. Ms. Weinstein Joins the Elite Group of A4M Certified Practitioners.

As a Cancer survivor and a mother of three beautiful, healthy children, Kristan's passion for functional medicine and early detection of "Dis-ease" in the body lead her to this point. "Health is truly your wealth," says Weinstein. "I was diagnosed with lymphoma when I was in nursing school. I was fortunate enough to be under the care of medical professionals that were using stem cell transplantation, a more progressive approach to treating cancer at the time. They saved my life. From that point forward, I knew that I needed to stay current and involved in creating a path for my future that would eventually enable me to treat patients preventatively. Often times we are treating the symptoms, when in fact there is so much evidence based science that tells us now, how to treat the cause or the 'dis-ease' before the disease itself takes over. This is why our expansion of 'Timeless Age Medical Group' was born."

About Functional Medicine Of total healthcare costs in the United States, more than 75% is due to chronic conditions. The key to reversing the rapidly spreading epidemic of chronic disease is to address the underlying causes and solutions for chronic disease, which are primarily driven by the lifelong, daily interaction among an individual's genetics, environment, and lifestyle choices. Functional medicine not only incorporates the latest in genetic science and systems biology, but it also enables health care practitioners to practice proactive, predictive, personalized medicine while empowering patients to take an active role in their own health. Kristan Weinstein-ANP-BC, is uniquely trained in the functional medicine model to identify and treat the root causes of chronic disease. In order to achieve the designation of A4M- Certified Practitioner, Kristan has completed 7 onsite training seminars and passed stringent written and case study evaluations. Weinstein joins an elite group of practitioners who fully certified in functional medicine

About A4MThe American Academy of Anti-Aging Medicine (A4M) is a US federally registered 501(c) 3 non-profit organization comprised of over 26,000 members including: physicians, health care practitioners, scientists, governmental officials, and members of the general public, representing over 120 nations.

The A4M is dedicated to the advancement of technology to detect, prevent, and treat aging related disease and to promote research into methods to optimize the human aging process. The A4M is also dedicated to educating physicians, scientists, and members of the public on biomedical sciences, breaking technologies, and anti-aging issues.

The A4M is comprised of over 26,000 members from 120 nations worldwide.

Expansion Phase for Timeless Age MedicalLaser Therapy Health & Wellness Center, formerly Laser Therapy Spa, LLC and, Inc has been in business over five years with over six thousand patients to date. With the expansion and upcoming launch of "Timeless Age Medical Group" we plan on serving our patients with the latest 21st century evidence based patient care well into future. Patient health and patient outcome remain our primary concern.

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Laser Therapy Health & Wellness Center, Inc Hallandale, Florida ... - Yahoo Finance

Testosterone treatment did not improve older mens memory or mental function in the latest results from landmark government research that challenges the anti-aging claims of popular supplements.

While testosterone use for one year appeared to strengthen bones and reduce anemia, it also showed signs of worsening artery disease. Questions also remain about other potential risks. The researchers said more studies are needed to determine long-term effects the kind of research the U.S. Food and Drug Administration has already asked supplement makers to conduct.

I dont think anybody would interpret these results as saying, Wow, this is a fountain of youth, this is a magical anti-aging potion,' said study co-author Susan Ellenberg, a University of Pennsylvania researcher.

The results are from the final four studies in a seven-part project mostly funded by the National Institute on Aging, involving nearly 800 U.S. men aged 65 and older with low testosterone levels. The goal was to see if rubbing testosterone gel on the skin daily for a year could treat problems linked with low levels of the male hormone, which declines with age. Half the men in each group used the real thing and half used fake gel.

Results published a year ago from the same research linked testosterone with mostly modest improvement in sexual performance, walking strength and mood.

The key new findings:

The overall health benefits, however, remain to be determined, the researchers said.

The studies were published Tuesday in the Journal of the American Medical Association and JAMA Internal Medicine. AbbVie Pharmaceuticals provided its gel for the study and helped pay for the research but had no other role in the study.

The research was not designed to look at risks and does not apply to younger men or those with normal levels of testosterone, said study leader Dr. Peter Snyder, a University of Pennsylvania hormone specialist. Its also not known if other forms of testosterone supplements would have similar effects in older men with low levels.

Prescription testosterone products, including gel, are approved only for men with low levels of the hormones caused by various medical conditions. Benefits and risks are unknown in men whose levels are low due only to aging, the FDA says. The agency requires testosterone labels to include possible risks for heart attacks and strokes, based on some previous studies.

A separate study published Tuesday in JAMA Internal Medicine found that men using prescription testosterone gel, patches or injections had fewer heart attacks and strokes than non-users during about three years of follow-up. But this was only observational data in men aged 40 and up, not rigorous research testing the hormone against a placebo.

Clarifying testosterones effects on heart problems, fractures and age-related disability will require larger, longer studies, said Dr. Evan Hadley of the National Institute on Aging. He said decisions about whether to use testosterone should take into account mens individual risks for conditions the hormone could affect.

See more here:
Testosterone Anti-Aging Studies: Some Benefits, But None to Mental ... - KQED

Recent research proves that vitamin D guards against colds, the flu and other respiratory illnesses. A daily dose of vitamin D supplements is especially helpful in the quest to fend off sickness. However, even a weekly dose of vitamin D will help in the prevention of colds and the flu. Those who are deficient in vitamin D will especially benefit from a regular dose of this incredibly helpful vitamin. Vitamin D is currently prescribed by physicians for an array of ailments.

Details of the Global Collaborative Study

A team of researchers from around the world determined vitamin D supplements combat the onset of numerous respiratory diseases. Carlos Camargo from Massachusetts General Hospital's Department of Emergency Medicine served as the study's senior author. The research was funded through a grant provided by the United Kingdom's National Institute of Health Research. The worldwide collaborative study confirms that vitamin D supplements help ward off acute respiratory infections.

The study consisted of a meta-analysis of 25 randomized trials with over 11,000 participants. The study's details and results were recently published on the web in The BMJ. It is widely known that vitamin D is vital for muscle and bone health. However, it was unclear as to whether vitamin D played a critically important role in combating acute respiratory infections. Such infections result in millions of hospital visits and deaths across the world each year. Clearing up Conflicting Data

A handful of observational studies that monitored patients across time without implementing a specific treatment had linked low levels of vitamin D to a higher susceptibility of acute respiratory infections. Several clinical trials have also been conducted to study vitamin D supplements' protective ability. Some of these studies determined the vitamin really does provide a protective quality. However, some studies showed that it does not have any protective effect. Meta-analyses performed of these clinical trials aggregated information from numerous studies that have differing designs and/or participant qualifications produced conflicting results.

The global research team referenced above cleared up these conflicting results. Queen Mary University of London's Adrian Martineau led the team. He performed a data meta-analysis of individual participants from over a dozen nations. Participants hailed from the United Kingdom, the United States, Canada and beyond. Prior meta-analyses pit average data from subjects in each study. Alternatively, individualized data meta-analysis distinguishes data from each participant, generating what is considered as a higher-resolution analysis of information across all studies.

The Results

It was determined that weekly and daily vitamin D supplements provided the optimal benefit for those who suffered from a severe vitamin D deficiency. This deficiency is defined as a blood level with 10 mg/dl or less. Vitamin D supplementation reduced the odds of a respiratory infection by one-half for such individuals suffering from a vitamin D deficiency. The study also found that every single participant enjoyed at least a minor benefit from consuming vitamin D supplements on a regular basis. It is worth noting that consuming occasionally high doses of the vitamin did not generate extensive benefits.

The hope is that people will ramp up their consumption of vitamin D supplements to reduce the risk of colds, the flu, and other respiratory maladies. This course of preventative action would prove especially helpful for those who are vitamin D deficient. Such supplementation would reduce the number of emergency department visits, which currently number in the millions. As a result, the health system would be less burdened. Furthermore, the study's findings might inspire food manufacturers to fortify foods with vitamin D. Such a measure would prove especially beneficial to those who are deficient in vitamin D.

Read more here:
Confirmed: Vitamin D Protects Against Colds and Flu - Worldhealth.net - Anti Aging News

Forbes

This Company With Anti-Aging Drug Is Secretly Preparing For Trump's New FDA Forbes Rather, their goal is to protect us from the medical and financial effects of aging. They want to extend the healthy portion of our lives (our health spans) for as long as possible. This is known as morbidity compression. A few decades ago, this goal ...

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This Company With Anti-Aging Drug Is Secretly Preparing For Trump's New FDA - Forbes

Posted on Feb. 23, 2017, 6 a.m. in Stem Cell Research Immune System Stem Cell

Autologous hematopoietic stem cell transplantation halted progression of Multiple Sclerosis for 5 years in 46% of patients.

Recent research indicates that the transplant of autologous hematopoietic stem cells (AHSCT) is an excellent treatment for multiple sclerosis. It has been determined that the procedure stops disease progression for half a decade in nearly 50 percent of multiple sclerosis patients.

About the Study

The study was spearheaded by Dr. Paolo Muraro from the Imperial College London's Department of Medicine. Dr. Muraro and his colleagues revealed their findings through JAMA Neurology. These results were released on the heels of a separate study that found the success of a similar treatment in patients suffering from relapsing-remitting multiple sclerosis (RRMS). Dr. Muraro and his research team are quick to point out that additional trials are necessary to gauge the efficacy and safety of AHSCT. It is important to note that some patients perished within the first 100 days of treatment.

About AHSCT

AHSCT involves the harvesting of a patient's own stem cells. The patient is subjected to a powerful dose of chemotherapy to destroy any diseased cells. The next step is the return of harvested stem cells to the patient's blood. The goal is to restart the production of normal blood cells.

In layman's terms, AHSCT is best understood as a resetting of the body's immune system. Though it was already known that this style of treatment resets the immune system and poses certain risks, the length of its benefits was not fully understood. We now have a better picture of these benefits. AHSCT Results

The research team studied data from over two dozen treatment centers in 13 countries. They pinpointed 281 patients who suffered from multiple sclerosis and underwent AHSCT from 1995 to 2006. Exactly 78 percent of these patients had a progressive form of multiple sclerosis. The team made use of the Expanded Disability Status Scale (EDSS) to analyze patients' survival after five years of treatment as well as improvements in their multiple sclerosis symptoms. A whopping 46 percent of these patients enjoyed zero disease progression in the five years following treatment. Those with RRMS, characterized by flare-ups (inflammatory attacks) and periods of remission enjoyed the optimal outcomes.

An amazing 73 percent of these patients did not endure worsening of symptoms in the 5 years following AHSCT. Some patients also experienced minor improvements in their multiple sclerosis symptoms following AHSCT. Those with progressive multiple sclerosis enjoyed a rise in EDSS score by 0.14 in the year after treatment. Those with RRMS experienced an EDSS score increase of 0.76. Those of a younger age, minimal immunotherapies before AHSCT and a comparably lower EDSS score also displayed improved outcomes with AHSCT. Treatment Risk

The findings described above clearly show promise for the AHSCT use in individuals who suffer from multiple sclerosis. The research team would like to make it perfectly clear that some patients died in the 100 days following AHSCT. Exactly eight patients perished in this time period. It is assumed that the deaths were related to treatment. AHSCT makes use of aggressive chemotherapy that significantly weakens the immune system and spikes one's risk for infection. Since multiple sclerosis is not a disease that is immediately life-threatening, the risk of death posed by AHSCT must be weighed by all multiple sclerosis patients.

What's next Dr. Muraro is adamant that a follow-up study must be performed that includes a group of multiple sclerosis patients who have not received AHSCT. It is clear that additional studies are required to accurately gauge the efficacy and safety of AHSCT. Ideally, a massive randomized controlled trial of AHSCT will be performed in the coming months.

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Stem Cell Therapy Halts Multiple Sclerosis - Anti Aging News

CHICAGO (AP) Testosterone treatment did not improve older men's memory or mental function in the latest results from landmark government research that challenges the anti-aging claims of popular supplements.

While testosterone use for one year appeared to strengthen bones and reduce anemia, it also showed signs of worsening artery disease and questions remain about other potential risks. The researchers said more studies are needed to determine long-term effects the kind of research the U.S. Food and Drug Administration has already asked supplement makers to conduct.

"I don't think anybody would interpret these results as saying, 'Wow, this is a fountain of youth, this is a magical anti-aging potion,'" said study co-author Susan Ellenberg, a University of Pennsylvania researcher.

The results are from the final four studies in a seven-part project mostly funded by the National Institute on Aging, involving nearly 800 U.S. men aged 65 and older with low testosterone levels. The goal was to see if rubbing testosterone gel on the skin daily for a year could treat problems linked with low levels of the male hormone, which declines with age. Half the men in each group used the real thing and half used fake gel.

Results published a year ago from the same research linked testosterone with mostly modest improvement in sexual performance, walking strength and mood.

The key new findings:

Testosterone had no effect on memory or mental function, based on tests given before, halfway and at the end of treatment to nearly 500 men with age-related memory decline.

Among almost 140 men who underwent heart artery imaging tests to see if the hormone slowed progression of plaque, those who used testosterone had more plaque buildup and narrower arteries after a year than the fake gel group. Those changes could signal increased chances for heart attacks although none occurred in the study. Men in this sub-study were already more vulnerable for heart problems because of conditions including artery disease, obesity and high blood pressure.

Among about 200 men given bone imaging tests before and at the end of treatment, those on testosterone showed increases in bone density and strength, especially in the spine, while minimal changes were found in the group that used fake gel. The improvement was similar to bone changes seen with treatment for osteoporosis, although most men studied did not have that bone-thinning condition, which can lead to fractures.

Among 126 men with anemia, a fatigue-linked condition involving inadequate red blood cells, those on testosterone showed substantial improvement. By the study's end, anemia had vanished in almost 60 percent of men on testosterone compared with 22 percent of the fake gel group. The hormone group also reported having more energy. "The overall health benefits, however, remain to be determined," the researchers said.

The studies were published Tuesday in the Journal of the American Medical Association and JAMA Internal Medicine. AbbVie Pharmaceuticals provided its gel for the study and helped pay for the research but had no other role in the study.

The research was not designed to look at risks and does not apply to younger men or those with normal levels of testosterone, said study leader Dr. Peter Snyder, a University of Pennsylvania hormone specialist. It's also not known if other forms of testosterone supplements would have similar effects in older men with low levels.

Prescription testosterone products including gel are approved only for men with low levels of the hormones caused by various medical conditions. Benefits and risks are unknown in men whose levels are low due only to aging, the FDA says. The agency requires testosterone labels to include possible risks for heart attacks and strokes, based on some previous studies.

A separate study published Tuesday in JAMA Internal Medicine found that men using prescription testosterone gel, patches or injections had fewer heart attacks and strokes during about three years of follow-up than non-users. But this was only observational data in men aged 40 and up, not rigorous research testing the hormone against a placebo.

Clarifying testosterone's effects on heart problems, fractures and age-related disability will require larger, longer studies, said Dr. Evan Hadley of the National Institute on Aging. He said decisions about whether to use testosterone should take into account men's individual risks for conditions the hormone could affect.

View post:
Testosterone gel shows no benefit for older men's memories - Shelbyville Daily Union

Baltimore Business Journal

Baltimore's InSilico Medicine raises $10M Baltimore Business Journal InSilico Medicine has raised $10 million from six investors, according to a filing with the Securities and Exchange Commission. InSilico collects and analyzes genetic codes to make drug discoveries for aging and age-related diseases. The company uses ... and more »

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Baltimore's InSilico Medicine raises $10M - Baltimore Business Journal

Adult stem cells collected directly from human fat are more stable than other cells such as fibroblasts from the skin and have the potential for use in anti-aging treatments, according to researchers from the Perelman School of Medicine at the University of Pennsylvania. They made the discovery after developing a new model to study chronological aging of these cells.

Chronological aging shows the natural life cycle of the cells as opposed to cells that have been unnaturally replicated multiple times or otherwise manipulated in a lab. In order to preserve the cells in their natural state, Penn researchers developed a system to collect and store them without manipulating them, making them available for this study. They found stem cells collected directly from human fat called adipose-derived stem cells (ASCs) can make more proteins than originally thought. This gives them the ability to replicate and maintain their stability, a finding that held true in cells collected from patients of all ages.

Our study shows these cells are very robust, even when they are collected from older patients, said Ivona Percec, MD, director of Basic Science Research in the Center for Human Appearance and the studys lead author. It also shows these cells can be potentially used safely in the future, because they require minimal manipulation and maintenance.

Stem cells are currently used in a variety of anti-aging treatments and are commonly collected from a variety of tissues. But Percecs team specifically found ASCs to be more stable than other cells, a finding that can potentially open the door to new therapies for the prevention and treatment of aging-related diseases.

Unlike other adult human stem cells, the rate at which these ASCs multiply stays consistent with age, Percec said. That means these cells could be far more stable and helpful as we continue to study natural aging.

ASCs are not currently approved for direct use by the Food and Drug Administration, so more research is needed. Percec said the next step for her team is to study how chromatin is regulated in ASCs. Essentially, they want to know how tightly the DNA is wound around proteins inside these cells and how this affects aging. The more open the chromatin is, the more the traits affected by the genes inside will be expressed. Percec said she hopes to find out how ASCs can maintain an open profile with aging.

Reference:

Shan, X., Roberts, C., Kim, E. J., Brenner, A., Grant, G., & Percec, I. (2017). Transcriptional and Cell Cycle Alterations Mark Aging of Primary Human Adipose-Derived Stem Cells. Stem Cells. doi:10.1002/stem.2592

This article has been republished frommaterialsprovided by Penn Medicine. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Potential of Adipose-derived Stem Cells in Anti-Aging Treatments - Technology Networks (press release) (registration) (blog)

By Lindsey Tanner, The Associated Press

CHICAGO Testosterone treatment did not improve older men's memory or mental function in the latest results from landmark government research that challenges the anti-aging claims of popular supplements.

While testosterone use for one year appeared to strengthen bones and reduce anemia, it also showed signs of worsening artery disease and questions remain about other potential risks. The researchers said more studies are needed to determine long-term effects the kind of research the U.S. Food and Drug Administration has already asked supplement makers to conduct.

"I don't think anybody would interpret these results as saying, 'Wow, this is a fountain of youth, this is a magical anti-aging potion,'" said study co-author Susan Ellenberg, a University of Pennsylvania researcher.

The results are from the final four studies in a seven-part project mostly funded by the National Institute on Aging, involving nearly 800 U.S. men aged 65 and older with low testosterone levels. The goal was to see if rubbing testosterone gel on the skin daily for a year could treat problems linked with low levels of the male hormone, which declines with age. Half the men in each group used the real thing and half used fake gel.

Results published a year ago from the same research linked testosterone with mostly modest improvement in sexual performance, walking strength and mood.

The key new findings:

Testosterone had no effect on memory or mental function, based on tests given before, halfway and at the end of treatment to nearly 500 men with age-related memory decline.

Among almost 140 men who underwent heart artery imaging tests to see if the hormone slowed progression of plaque, those who used testosterone had more plaque buildup and narrower arteries after a year than the fake gel group. Those changes could signal increased chances for heart attacks although none occurred in the study. Men in this sub-study were already more vulnerable for heart problems because of conditions including artery disease, obesity and high blood pressure.

Among about 200 men given bone imaging tests before and at the end of treatment, those on testosterone showed increases in bone density and strength, especially in the spine, while minimal changes were found in the group that used fake gel. The improvement was similar to bone changes seen with treatment for osteoporosis, although most men studied did not have that bone-thinning condition, which can lead to fractures.

Among 126 men with anemia, a fatigue-linked condition involving inadequate red blood cells, those on testosterone showed substantial improvement. By the study's end, anemia had vanished in almost 60 percent of men on testosterone compared with 22 percent of the fake gel group. The hormone group also reported having more energy. "The overall health benefits, however, remain to be determined," the researchers said.

The studies were published Tuesday in the Journal of the American Medical Association and JAMA Internal Medicine. AbbVie Pharmaceuticals provided its gel for the study and helped pay for the research but had no other role in the study.

The research was not designed to look at risks and does not apply to younger men or those with normal levels of testosterone, said study leader Dr. Peter Snyder, a University of Pennsylvania hormone specialist. It's also not known if other forms of testosterone supplements would have similar effects in older men with low levels.

Prescription testosterone products including gel are approved only for men with low levels of the hormones caused by various medical conditions. Benefits and risks are unknown in men whose levels are low due only to aging, the FDA says. The agency requires testosterone labels to include possible risks for heart attacks and strokes, based on some previous studies.

A separate study published Tuesday in JAMA Internal Medicine found that men using prescription testosterone gel, patches or injections had fewer heart attacks and strokes during about three years of follow-up than non-users. But this was only observational data in men aged 40 and up, not rigorous research testing the hormone against a placebo.

Clarifying testosterone's effects on heart problems, fractures and age-related disability will require larger, longer studies, said Dr. Evan Hadley of the National Institute on Aging. He said decisions about whether to use testosterone should take into account men's individual risks for conditions the hormone could affect.

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Online:

National Institute on Aging: http://www.nia.nih.gov

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Testosterone gel shows no benefit for older men's memories - The Ledger

SAITAMA The health ministry on Monday ordered a Saitama clinic to stop injecting stem cells of human umbilical cord blood into patients as an anti-aging treatment.

Saitama Medical Clinic in Tokorozawa, Saitama Prefecture, was found to have been engaged in such therapy without getting permission from the ministry. The regenerative medicine safety law mandates that all hospitals and clinics submit plans for stem cell therapy and get permission from the ministry beforehand.

The ministry conducted an on-site inspection of the clinic on Friday, based on tips from an outsider, and confirmed the clinic offered the unauthorized therapy, boasting that umbilical cord cell shots would boost health and help with anti-aging.

Several men and women are believed to have undergone treatment there. The ministry has asked the clinic to report the number of cases, any health damage and the kind of stem cells used and how they were obtained.

For clinics to receive approval for medical procedures using cells of others, they need to submit a detailed plan and have it screened by a panel of experts under the health ministry. The clinic had not submitted such a plan.

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Saitama clinic ordered to halt unauthorized stem cell 'anti-aging' therapy using umbilical cord blood - The Japan Times

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Excellent weapon in war on aging - Palm Beach Post

Human fat could be the answer to more effective anti-aging treatments, researchers at the University of Pennsylvania say.

The researchers at Penn's Perelman School of Medicine said Friday they discovered adult stem cells from fat are more stable than other stem cells, such as those taken from skin, that are currently used in a variety of anti-aging treatments.

The cells from fat, called adipose-derived stem cells (ASCs), have the ability to make more protein that originally thought, therefore allowing them to replicate and maintain their stability.

Our study shows these cells are very robust, even when they are collected from older patients, said lead author Ivona Percec, MD.

The discovery "can potentially open the door" for new treatments and therapies to address aging-related diseases.

The researchers noted that ASCs are not currently approved for direct use by the Food and Drug Administration. They said more research is needed before potential implementation of their finding.

The finding was published in the February edition of the "Stem Cells" medical journal.

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How fat could lead to more effective anti-aging treatments - PhillyVoice.com