(MENAFN Editorial)

The International Association of HealthCare Professionals is pleased to welcome Dr. Faruk Said Abuzzahab Sr., MD, PhD, to their prestigious organization with his upcoming publication in The Leading Physicians of the World. He is a highly-trained psychiatrist, pharmacologist, and anti-aging physician with extensive expertise in all facets of his work. Dr. Faruk Said Abuzzahab Sr. has been practicing for over 57 years and is currently serving patients within Clinical Psychopharmacology Consultants in Minneapolis, Minnesota. He is also affiliated with the University of Minnesota Medical Center.

Dr. Faruk Said Abuzzahab Sr. obtained his Doctor of Medicine Degree from the American University of Beirut in Lebanon in 1959. After completing internship in Beirut, Dr. Abuzzahab Sr. moved to the United States and completed a residency at Johns Hopkins Hospital. He then went on to undertake his Pharmacology fellowship at the University of Minnesota. Additionally, Dr. Abuzzahab also holds a Doctor of Philosophy Degree.

Dr. Abuzzahab Sr. is an internationally renowned expert in the chemistry of the brain, and is a specialist in delaying the aging process in the brain. He maintains a professional membership with the American Academy of Anti-Aging Medicine, and since 2001 has organized annual anti-aging conferences. Dr. Abuzzahab Sr. attributes his success to the examples he gained from his parents and the inspiration they provided him with.

ew Faruk Said Abuzzahab Sr.'s Profile Here: https://www.findatopdoc.com/doctor/8138176-Faruk-Abuzzahab-psychiatrist-Minneapolis-Minnesota-55416

Learn more about Dr. Abuzzahab Sr. by reading his upcoming publication in The Leading Physicians of the World.

About FindaTopDoc.com

FindaTopDoc.com is a hub for all things medicine, featuring detailed descriptions of medical professionals across all areas of expertise, and information on thousands of healthcare topics. Each month, millions of patients use FindaTopDoc to find a doctor nearby and instantly book an appointment online or create a review. FindaTopDoc.com features each doctor's full professional biography highlighting their achievements, experience, patient reviews and areas of expertise. A leading provider of valuable health information that helps empower patient and doctor alike, FindaTopDoc enables readers to live a happier and healthier life. For more information about FindaTopDoc, visit: http://www.findatopdoc.com

SOURCE:International Association of HealthCare Professionals

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Esteemed Psychiatrist, Pharmacologist and Anti-Aging Physician in Minneapolis, Minnesota Faruk Said Abuzzahab Sr ... - MENAFN.COM

KHON2

University of Hawaii, Cardax say study shows anti-aging potential Pacific Business News (Honolulu) The University of Hawaii's John A. Burns School of Medicine and Honolulu-based life sciences company Cardax Inc. have announced the results of an animal study evaluating the effectiveness of the naturally-occurring chemical astaxanthin that holds ... Activation of 'longevity gene' could lead to promising anti-aging ...KHON2 Astaxanthin Activates the FOX03 'Longevity Gene'Anti Aging News Promising anti-aging gene therapy developed through innovative partnershipUH System Current News all 10 news articles »

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University of Hawaii, Cardax say study shows anti-aging potential - Pacific Business News (Honolulu)

The Latest Trends in Skin, Beauty, and Wellness Offered by Michigans Rejuvenation Experts

Published: March 28, 2017

- A D V E R T I S E M E N T -

Always at the forefront of innovation in beauty and wellness, FACE and Cutler Integrative Medicine have joined to form the ultimate state-of-the-art, award-winning rejuvenation destination. The founders, Dr. Doug Cutler and Holly Cutler, have brought their naturopathic medical and esthetic backgrounds together to merge their expertise in inside-out anti-aging.

Almost two decades ago, Holly Cutler, also known as Americas Skin Saint, rebuilt her own skin, which had been disfigured by cystic acne. Since then, she has created one of the most extensive rejuvenation clinics in the U.S., offering more than 30 laser and facial machines, liquid face-lifts, vaginal rejuvenation, and body makeovers. With her innovative Skin Management Model and her one-hour transformations, Cutler has helped thousands of people who were not satisfied elsewhere. She has been a featured expert on FOX, CBS, NBC, ABC, and The Doctors Show, and has appeared on magazine covers and in several publications. Cutler has now launched her own highly anticipated and innovative skincare product line to help people all over the country who may not be able to access the services at her clinic. She is also anticipating the publication of her new book, No Filters Needed, a guide to enjoying the best skin possible for years to come.

The wellness division, headed by Dr. Doug Cutler, a licensed naturopathic physician, finds the root cause of imbalances in the body to create overall well-being from the inside out. His state-of-the-art clinic incorporates natural elements, and air and water purification systems, and is home to one of the most advanced detoxification clinics in the country. Dr. Cutler is the only doctor in Michigan who has the most advanced training in environmental medicine and genetic polymorphisms. His specialties include integrative medicine; anti-aging medicine; botanical medicine; detoxification therapies; nutrition, mental, and neurological conditions; womens disorders; childrens health; and more.

Dr. Cutler recently launched his new ClubIV, one of the only FDA/USP-compliant IV/IM

(intravenous/intramuscular) nutrient therapy clinics in Michigan. The advanced nutrient formulas are customized to increase energy, improve sleep, optimize immune function, recover cellular homeostasis, promote healing and recovery, reduce stress and anxiety, support weight loss, and much more. There is no comparison to the superior potency of nutrients delivered via IV/IM therapy. The dose bypasses the gastrointestinal system and is delivered directly into the bloodstream, so results are fast allowing you to feel better, sooner.

Most people can benefit from IV/IM therapy. At your first visit, an evaluation is conducted to determine which combination of vitamins, minerals, and other nutrients will work best for you.

The range of therapies includes anti-aging, anti-inflammatory, antioxidant, detoxification, endocrine, hydration, metabolism, recovery, and wellness. The dedicated infusion room is relaxing and peaceful; during your IV session you may experience local warmth, an increase in energy, or a deepening sense of calm and well-being.

Dr. Cutler is a member of the American Association of Naturopathic Physicians, the Michigan Association of Naturopathic Physicians, the American College for Advancement in Medicine, and the Pediatric Association of Naturopathic Physicians, and he is the board director for the Naturopathic Academy of Environmental Medicine.

As rejuvenation experts, the team of Dr. Doug Cutler and Holly Cutler can enhance your health, improve your overall quality of life, and keep you looking youthful for years to come.

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FACE Forward - Hour Detroit Magazine

Victoria Advocate

Fountain of Youth to celebrate 10th anniversary Victoria Advocate Le, a physician who specializes in internal medicine, aesthetic medicine and anti-aging medicine, moved into the shopping center about 10 years ago. "It's quite a journey, and we want to celebrate the contributions our business has brought to the ...

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Fountain of Youth to celebrate 10th anniversary - Victoria Advocate

Fort Lauderdale, FL Life Extension has partnered with Insilico Medicine to introduce Ageless Cell, the first supplement in its GEROPROTECT line to promote healthy aging by inhibiting cellular senescence.

Cellular senescence is a natural part of the aging process where cells no longer function optimally, affecting organ function, cellular metabolism, and the inflammation response. The accumulation of these senescent cells contributes to the process of aging. The Ageless Cell supplements inhibit the effects of cellular senescence by acting as geroprotectors, or interventions aimed to increase longevity and impede the onset of age-related diseases by targeting and inhibiting senescence-inducing pathways and inhibiting the development of senescent cells.

The partnership with Insilico Medicine allowed researchers to use deep learning algorithms to comb through hundreds of studies and thousands of data points a process that could have taken decades to identify four key anti-aging nutrients: N-Acetyl-L-Cysteine (NAC), myricetin, gamma-tocotrienol, and EGCG. These compounds target pathways that are known to contribute to or protect against the development of senescent cells.

Specifically, NAC upregulates signaling pathways that protect cells against oxidative stress, which promotes cellular senescence. It also reduces pathways that promote inflammation. Myricetin regulates a family of stress-responsive signaling molecules known to regulate aging in many tissues. It also promotes cell differentiation and self-repair. Gamma tocotrienol modulates the mevalonate pathway that controls cholesterol production, cancer promotion, and bone formation. And EGCG regulates the Wnt pathway that determines the fate of developing cells and also prevents sugar-induced damage to tissues, helping to suppress their pro-aging effects.

Clinical aging studies are extremely difficult, if not impossible, to perform at this time. Our collaboration with Insilico Medicine has allowed us to develop geroprotective formulations by using artificial intelligence to study very large data sets, said Andrew G. Swick, Ph.D., senior vice president of product development and scientific affairs for Life Extension.

Scientists found these four nutrients have various complementary and reinforcing properties to influence key anti-aging pathways and combat aging factors by modulating specific biological pathways. By rejuvenating near-senescent cells and encouraging the bodys healthy process for dealing with senescent cells, Ageless Cell turns back the clock at the cellular level, said Michael A. Smith, M.D., senior health scientist for Life Extension.

Alex Zhavoronkov, Ph.D., CEO of Insilico Medicine said, Together, these four natural compounds represent the beginning of the future anti-aging cocktails identified using artificial intelligence under expert human supervision.

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Life Extension and Insilico Medicine Use Artificial Intelligence to Develop Ageless - WholeFoods Magazine

HONOLULU--(BUSINESS WIRE)--Cardax, Inc. (Cardax) (OTCQB:CDXI) and the University of Hawaii (UH) announced today that Cardaxs proprietary astaxanthin compound, CDX-085, demonstrated an almost 90% increase in FOXO3 gene expression in mice (p=0.024).

This research was conducted by UH scientists Dr. Bradley Willcox, M.D., Professor and Director of Research at the Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii (JABSOM) and Principal Investigator of the NIH-funded Kuakini Hawaii Lifespan and Healthspan Studies, and Dr. Richard Allsopp, Ph.D., Associate Professor, Institute of Biogenesis Research at JABSOM.

Previously in humans, Dr. Willcox and colleagues discovered genetic variants of FOXO3 in humans that protect against aging (Willcox et al. Proc US Natl Acad Sci 2008).

This observation has since been replicated in >20 independent studies. At the American Heart Association Meeting in 2015, it was announced that the protective FOXO3 allele is strongly associated with reduced coronary heart disease mortality (p=0.00001) (AHA Meeting 2015) and later published in the leading gerontology journal (Willcox et al. J Gerontol Biol Med Sci 2016).

These results augment earlier findings in the C. elegans roundworm, a well-accepted model of aging, said Dr. Allsopp, where astaxanthin extended lifespan by 16-30%.

All of us have the FOXO3 gene, which protects against aging in humans, said Dr. Willcox. But about one in three persons carry a version of the FOXO3 gene that is associated with longevity. By activating the FOXO3 gene common in all humans, we can make it act like the "longevity" version. Through this research, we have shown that astaxanthin activates the FOXO3 gene.

This exciting new evidence provides yet another reason for physicians and patients to consider an astaxanthin dietary supplement such as ZanthoSyn as the foundation of an anti-aging, longevity program, said David G. Watumull, Cardax CEO.

About CDX-085

CDX-085 is the patented active ingredient of Cardaxs second generation product and like its first generation dietary supplement, ZanthoSyn, delivers astaxanthin to the blood stream with excellent absorption and purity, but in a more concentrated form, allowing higher doses per capsule and improved dosing convenience. Astaxanthin is a safe anti-inflammatory for general health that supports anti-aging and longevity.*

About FOXO3

FOXO3 is a member of the forkhead family of transcription factors. The human homolog in C. elegans, daf-16, has profound effects on longevity (Kenyon et al. A C. elegans mutant that lives twice as long as wild type. Nature 1993). Scientists led by Dr. Bradley Willcox, MD, member of the Cardax scientific advisory board, discovered a genetic variant of FOXO3 in humans that protects against aging (Willcox et al. Proc US Natl Acad Sci 2008). This observation has since been replicated in >20 independent studies. The protective FOXO3 allele (G allele) is associated with longevity with one G allele (GT genotype) doubling the odds to live to 100 and two G alleles (GG genotype) tripling the odds to live to 100. The protective FOXO3 allele is strongly associated with reduced coronary heart disease mortality (p=0.00001) (Willcox et al. AHA Meeting 2015) and the protective FOXO3 allele is strongly associated with reduced serum inflammatory markers (CRP and TNF-).

About Cardax

Cardax devotes substantially all of its efforts to developing and commercializing safe anti-inflammatory dietary supplements and drugs. Cardax is initially focusing on astaxanthin, which is a powerful and safe naturally occurring anti-inflammatory without the side effects of currently marketed anti-inflammatories. The safety and efficacy of Cardax's products have not been directly evaluated in clinical trials or confirmed by the FDA.

Safe Harbor

This release may contain certain forward-looking statements regarding our prospective performance and strategies within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. We intend such forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995, and are including this statement for purposes of said safe harbor provisions. Forward-looking statements, which are based on certain assumptions and describe future plans, strategies, and expectations of our company, are generally identified by use of words anticipate, believe, estimate, expect, intend, plan, project, seek, strive, try, or future or conditional verbs such as could, may, should, will, would, or similar expressions. Our ability to predict results or the actual effects of our plans or strategies is inherently uncertain. Accordingly, actual results may differ materially from anticipated results. Some of the factors that could cause our actual results to differ from our expectations or beliefs include, without limitation, the risks discussed from time to time in our filings with the Securities and Exchange Commission. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this release. Except as required by applicable law or regulation, we undertake no obligation to update these forward-looking statements to reflect events or circumstances that occur after the date on which such statements were made.

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Cardax Astaxanthin Compound CDX-085 Stimulates Anti-Aging ... - Business Wire (press release)

Forget the Fountain of Youth; scientists are closer than ever to creating a safe and effective anti-aging drug, its been revealed.

Through a series of experiments on mice, researchers from Harvard Medical School and the University of New South Wales School of Medicine in Australia have discovered an essential clue as to how our cells repair damaged DNA. This is important because the bodys inability to mend DNA can result in age-related deterioration, claim the scientists.

They go on to say that when humans are young, they have great amounts of the DNA-repairing protein PARP1. As we age, however, another protein called DBC1 clings to it, rendering it impossible to finish its recon work. This makes it increasingly difficult for our systems to fix broken DNA.

In their study, the researchers fed old mice a molecule called NMN. The mice metabolized it into a signalling molecule called NAD, which squeezed in between the PARP1 and DBC1 proteins and pushed them apart. The DNA-repairing protein was then able to work effectively again, just like when the mice were younger.

This restored the DNA capacity of the old mouse back to a young mouse, and also to remove the DNA damage that accumulated in the tissue, said study author David Sinclair, Ph.D.

The scientists then exposed the mice to DNA-damaging radiation. The mice that were treated with the NMN molecule didnt show the usual effects of radiation, which include changes in white blood cell counts and hemoglobin levels.

While the scientists push that the NMN treatment has only been tested in mice and that the results may be different in people, they hope to begin human trials within six months.

This is the closest we are to a safe and effective anti-aging drug thats perhaps only three to five years away from being on the market if the trials go well, Sinclair said.

The drug could one day serve as a treatment for preventing DNA damage from aging, radiation and even chemotherapy.

h/t Mens Health

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Scientists Are One Step Closer To An Anti-Aging Drug - Civilized

Posted on March 28, 2017, 6 a.m. in Sleep Brain and Mental Performance

New research explains how synapses in the cortex expand with daytime stimulation and shrink with sleep, resetting the brain and preparing it for the next day.

The need for, and mechanisms that drive sleep have consistently puzzled scientists. However, novel work from researchers at the University of Wisconsin School of Medicine and Public Health have tested their synaptic homeostasis hypothesis (SHY) for why animals need sleep. SHY theory describes a need for sleep

This four-year study by Luisa de Vivo and her colleagues, published in Science, supported the SHY theory. The SHY theory describes changes in synapses during waking and sleeping hours. Synapses are the junctions between two neurons, the larger the synapse, the stronger these two neurons can communicate - this ease of communication is how animals learn skills and make memories. Yet in order for brains to be pliable and learn new things, the synapses must shrink so these neural pathways can be activated again. SHY theory suggests that sleep allows these synapses to shrink.

According to SHY theory, sleep provides the perfect environment for the shrinking of synapses, allowing the brain to learn new things following day. The lack of stimulation while sleeping results in reduced activity between neurons, and therefore the distance between the neurons grows smaller allowing them to be activated with a weaker stimulation. This phenomenon allows brains to make new neural connections the following day, thereby allowing new memories to form and more efficient learning.

Testing SHY theory

Lead author Luisa de Vivo, along with her fellow researchers, tested their theory by measuring the size of synapses both before and after sleep. They utilized three-dimensional scanning electron microscopy to visualize and reconstruct the mouse brain and measured nearly 7000 synapses. They specifically looked at neurons involved in motor functions and sensory perception. The team then repeated this process after the mice had slept (making sure to note how long the mice had slept), and measured the synapses again.

The researchers found that the synaptic size correlated with the amount of sleep the mice had. The longer the mice had slept, the smaller the synapses had become with a few hours sleep resulting in the reduction by ~18 percent. Interestingly, the researchers only observed this phenomenon in ~80 percent of synapses and that the largest of synapses appeared not to be susceptible to the shrinking. They hypothesize that these synapses might not follow the pattern because those synapses are associated with stable, long-term memories or skills. These results support SHYs central tenant that the function of sleep is to renormalize synapse size that increases throughout the day. The researchers theorize that the shrinking of the synapses might be related to the lack of neurotransmitters during sleep, especially noradrenaline.

Giulio Tononi, head of the research group and Chair of Sleep Medicine at the University of Wisconsin believes the relevance of this works extends beyond mice, "extrapolating from mice to humans, our findings mean that every night trillions of synapses in our cortex could get slimmer by nearly 20 percent,"

The lack of stimulation that brains receive during sleep allows specific synapses to shrink, resulting in a brain that is ready to learn and create new memories the following day. This research provides rational to the large body of work that suggests animals learn skills better following a long sleep. Important synapses and neural pathways seem immune to this process of renormalization indicating that systems have evolved to preserve important memories and skills.

Ultrastructural evidence for synaptic scaling across the wake/sleep cycle Luisa de Vivo1, Michele Bellesi1,2, William Marshall1, Eric A. Bushong3, Mark H. Ellisman3,4, Giulio Tononi1,*, Chiara Cirelli1,* Science 03 Feb 2017: Vol. 355, Issue 6324, pp. 507-510 DOI: 10.1126/science.aah5982

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Brain Resets During Sleep - Anti Aging News

Posted on March 27, 2017, 6 a.m. in Cardio-Vascular Diagnostics

More than half of family doctors in Canada are still using manual devices, a dated technology that often leads to misdiagnosis.

A study by researchers at the University of Montreal Hospital Research Centre (CRCHUM) reports that over half of the Canadian family doctors are still making use of manual devices to measure blood pressure, which is a dated technology. Using a manual device to measure blood pressure often leads to misdiagnosis. Approximately 20% of those receiving treatment for hypertension don't actually have it and do not need medication.

Automatic electronic devices, called oscillometric devices, are available and are recommended by the Guidelines of the Canadian Hypertension Education Program (CHEP) as preferable to manual measurement.

However, in the spring of 2016, the team that conducted the survey among the Canadian family doctors found that 52% of the 769 who responded stated that they made use of a manual tensiometer to measure patients' blood pressure, and only 43% used an automatic device.

The lead author of the study, Janusz Kaczorowski, is a medical sociologist, a CRCHUM researcher, and a professor in the Department of Family and Emergency Medicine.

Manual measurement is acceptable if it is done properly, but that is not always the case. Kaczorowski stated that clinicians should use automatic devices because they are more precise and take several measurements. Automated measurement has an advantage because it eliminates white-coat syndrome, which is an artificially high blood pressure reading that is a result of being in a doctor's office.

To take blood pressure properly, a 12- to 15-minute period is required with the patient being left alone in a room while the measurement is taken. That is difficult because the average visit to a family doctor lasts only 10 minutes.

Blood pressure is the pressure that the blood exerts on the walls of arteries. Measured in an artery in the arm, blood pressure has two measurements: systolic as the heart contracts and diastolic as the heart relaxes. Normal pressure has the systolic pressure at below 140 mmHg and the diastolic pressure at below 90 mmHg. Above those numbers, a person is said to have high blood pressure or hypertension.

In Canada, one of every five adults suffers from hypertension, which is the greatest global risk factor for disability and death. Healthcare costs due to hypertension were evaluated at over $13 billion in 2010. Kaczorowski says that if blood pressure was measured incorrectly, there are considerable financial implications as well as possible side effects, which could be avoided.

The CHEP Guidelines state that modification of health-related behaviors is an efficient way of treating and preventing high blood pressure and reducing the cardiovascular disease risk. It is possible to lower one's blood pressure with a healthy diet, reduced intake of sodium, regular physical activity, moderate consumption of alcohol, tobacco product avoidance, and stress management.

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Is it Really High Blood Pressure? - Anti Aging News

Were living longer these days, but that hasnt stopped newer branches of medicine from trying to enhance and further extend our lifespans.

Researchers in longevity medicine and biogerontology are studying drugs and compounds that can prevent and reverse aging on the cellular level.

Over the past few years, public interest in longevity issues has grown, but that interest is mostly in health-extending therapies, not simply life-extending therapies. Most people are interested in living longer, but only if they can also be healthier longer, Sonia Arrison, author of 100 Plus: How the Coming Age of Longevity Will Change Everything, From Careers and Relationships to Family and Faith, and founder of Singularity University in California, told Healthline.

While many people are focused on lifestyle changes, the addition of drugs rapamycin and metformin are two that Arrison mentioned gives humans more options to extend their lives as well as the quality of their lives.

Compared with preventative drugs such as statins to avoid having a heart attack, anti-aging drugs fight multiple diseases at once instead of focusing on one ailment, Arrison added.

A person who goes by the name Reason, a technologist and author on FightAging.org, which highlights health- and longevity-enhancing medical technologies, told Healthline that the drugs are targeting a wide range of age-related ailments and diseases.

All age-related diseases are age-related because they are caused by the processes of aging, which is to say an accumulation of damage in cells and tissues, Reason wrote in an email.

Read more: Botox may have long-lasting, anti-aging effects

The field of geroprotection involves understanding cell senescence, which is when cells stop dividing.

When senescent cells no longer divide, they stop functioning, so organ health deteriorates. Cell senescence also causes the release of proinflammatory cytokines, which damage tissues.

This arena involves the use of geroprotectors, which are compounds that can stop or reverse cellular aging, and senolytics, which are compounds that can pinpoint and destroy senescent cells.

This is why researchers are looking into geroprotectors and senolytics, which requires long spans of time to understand.

In essence, todays researchers may never see the outcomes of the research theyve started because it can take decades to study. Nevertheless, scientists continue to try to understand these compounds and how they can alter our cells.

Researchers are also looking into our cells telomeres, which are short segments of DNA in our chromosomes that protect cells from wear and tear that comes with aging. As cells divide, they can shorten and no longer protect the chromosome or cell.

Lengthening them is the focus of recent research. Last year, a BGRF study was able to lengthen human telomeres.

A recent report in the journal Cell detailed how peptides were able to boost the life span of mice. The study examined how cell therapy could reverse poor age-related kidney function, fur loss, and frailty in mice.

Scientists are looking into whether or not the approach can also prolong the life span of mice. Human safety studies are in the works.

Reason said there are two schools of thought when exploring extending life through genetic pathways.

One approach is to alter cellular metabolism and make cells age more slowly, but the work is difficult and expensive. The other is to fix old tissue because we understand how it compares with young tissue.

No one yet fully understands everything these [older] cells do to us, but the fastest way to find out is to get rid of them, and we know that doing that in mice extends life and reverts aspects of aging, Reason explained.

Either you slow down the damage, or you repair the damage. Aging is damage. It is in the how of achieving one of those goals that all the complexity starts up, Reason added.

Read more: Beer may keep your DNA young, study says

The Human Aging Genomic Resources (HAGR) website recently released DrugAge, a database of lifespan-extending drugs and compounds.

It includes 418 compounds that were recorded from studies on 27 different model organisms.

HAGR already operates the GenAge database of age and longevity-related genes in humans and model organisms. They also operate AnAge, which has aging and longevity records of more than 4,000 species, the GenDR database of genes associated with the life-extending effects of dietary restriction, and LongevityMap, which includes more than 2,000 human gene and genetic variations linked to longevity.

DrugAge incorporates earlier efforts by Biogerontology Research Foundation (BGRF) scientists, who produced Geroprotectors.org. Right now, its the largest database of its kind.

According to the research teams from BGRF and the University of Liverpool, pharmaceuticals have not targeted most age-related pathways. The research is only focused on a small number of pathways that are currently known.

The goal behind the database is to pave the way for discovery of new life span-extending and health span-extending compounds.

I am confident that it [DrugAge] will gain widespread use in the aging research community, and represents a significant milestone along the way to the coming paradigm shift in modern healthcare away from single disease treatment and toward geroprotective multi-disease prevention, Dmitry Kaminskiy, managing trustee of BGRF, said in a statement.

Franco Cortese, deputy director and trustee of BGRF, said in a statement the database will be extremely valuable for biogerontologists. The BGRF did not respond to Healthlines request for comment.

Already, researchers are using the data to identify trends and develop a better understanding of the comparative effects of geroprotectors on organisms.

Arrison is excited when she sees people teaming up globally to battle human disease and decline something that the DrugAge team is hoping to do with their database.

The more knowledge the health community can get, the better. The wonderful thing about the internet is that knowledge gets distributed faster, making the quest for cures that much quicker, Arrison added.

Read more: Study breaks down aging process, may lead to solutions

Read more from the original source:
New Drugs That Could Help Us Live Longer - Healthline

Cromwell Schubarth TechFlash Editor Silicon Valley Business Journal Silicon Valley Business Journal It's focused on extending human health span, initially focused on diseases of aging. The big idea is that its drugs have been given to animals and those animals are surviving 25 percent to 30 percent longer. Importantly, they're surviving with shiny ...

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Cromwell Schubarth TechFlash Editor Silicon Valley Business Journal - Silicon Valley Business Journal

Question: My hormone replacement is not working; is there anything new?

Answer: Hormones affect every aspect of our lives, including general health, mood and overall well-being. The last 10 years have seen a dramatic change in attitude as to how men and women should be treated for hormonal imbalances.

While the movement toward bio-identical hormones has been appropriate from a safety standpoint, the delivery of hormones has been a source of frustration for many patients and their doctors. Because oral therapies have greater risks, patients have been encouraged to try creams, gels, injections and patches.

The issues with these delivery methods are uncontrolled fluctuations in hormone levels, poor absorption into the body, and messy and inconvenient treatment regimens. The net result is that, for many people, their symptoms are not effectively relieved, and the health benefits are not fully realized.

The answer lies in a therapy that, while popular worldwide, is only now beginning to receive the attention it deserves in the U.S. Pellet hormonal therapy seems to be the ideal solution to finding a safe, convenient, reliable and natural delivery of hormonal therapy. Pellets contain pure hormone that is not metabolized into unwanted byproducts, and allows your body to use the right amount of hormone to create better moods, vitality, and health and well-being.

Please join us for a Night of Beauty fundraiser for Project Brilliance. Silent Auction, DJ, Food, Fun, Hair Make Up and More! RSVP to 561-655-6325.

Daniela Dadurian, M.D., specializes in anti-aging medicine and is an expert in non-surgical body-contouring techniques. She received her medical degree from the University of Miami School of Medicine and has traveled the world researching the safest and latest technologies on the market.

MD Beauty Labs Medical Spa and Wellness Center

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New hormone treatment gaining popularity - Palm Beach Post

March 23, 2017 Two fast-aging mice. The mouse on the left was treated with a FOXO4 peptide, which targets senescent cells and leads to hair regrowth in ten days. The mouse on the right was not treated with the peptide. Credit: Peter L.J. de Keizer

Regular infusions of a peptide that can selectively seek out and destroy broken-down cells that hamper proper tissue renewal, called senescent cells, showed evidence of improving healthspan in naturally-aged mice and mice genetically engineered to rapidly age. The proof-of-concept study, published March 23 in Cell, found that an anti-senescent cell therapy could reverse age-related loss of fur, poor kidney function, and frailty. It is currently being tested whether the approach also extends lifespan, and human safety studies are being planned.

The peptide took over four years of trial and error to develop and builds on nearly a decade of research investigating vulnerabilities in senescent cells as a therapeutic option to combat some aspects of aging (Trends in Molecular Medicine, 10.1016/j.molmed.2016.11.006). It works by blocking the ability of a protein implicated in senescence, FOXO4, to tell another protein, p53, not to cause the cell to self-destruct. By interfering with the FOXO4-p53 crosstalk, the peptide causes senescent cells to go through apoptosis, or cell suicide.

"Only in senescent cells does this peptide cause cell death," says senior author Peter de Keizer, a researcher of aging at Erasmus University Medical Center in the Netherlands. "We treated mice for over 10 months, giving them infusions of the peptide three times a week, and we didn't see any obvious side effects. FOXO4 is barely expressed in non-senescent cells, so that makes the peptide interesting as the FOXO4-p53 interaction is especially relevant to senescent cells, but not normal cells."

Results appeared at different times over the course of treatment. Fast-aging mice with patches of missing fur began to recover their coats after 10 days. After about three weeks, fitness benefits began to show, with older mice running double the distance of their counterparts who did not receive the peptide. A month after treatment, aged mice showed an increase in markers indicating healthy kidney function.

Senescent cell therapy is one of several strategies being tested in mice aimed at reversing aging or lengthening healthspan. In 2015, the Valter Longo laboratory at the University of Southern California reported that mice on a calorie-restricted diet that mimics fasting benefited from a longer life, a reduction in inflammatory disease, and improved memory (Cell Metabolism, 10.1016/j.cmet.2015.05.012). And last December, Juan Carlos Izpisua Belmonte at the Salk Institute of Biological Science and colleagues made headlines with their discovery that cellular reprogramming of epigenetic marks could extend lifespan and improve health in fast-aging mice (Cell, 10.1016/j.cell.2016.11.052).

"This wave of research on how we can fight aging is complementary, and not in competition," says de Keizer. "The common thread I see for the future of anti-aging research is that there are three fronts in which we can improve: The prevention of cellular damage and senescence, safe therapeutic removal of senescent cells, to stimulate stem cellsno matter the strategyto improve tissue regeneration once senescence is removed."

de Keizer aims to start a company based on these findings, but in the short term, he and his group want to show that their peptide is non-toxic in humans with no unforeseen side effects. They plan to offer a safety clinical trial in people with Glioblastoma multiforme, an aggressive brain tumor, which also shows high levels of the biomarkers needed for this FOXO4 peptide to be effective.

Explore further: Anti-aging therapies targeting senescent cells: Facts and fiction

More information: Cell, Baar et al.: "Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging" http://www.cell.com/cell/fulltext/S0092-8674(17)30246-5 DOI: 10.1016/j.cell.2017.02.031

Sebastian Brandhorst et al. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan, Cell Metabolism (2015). DOI: 10.1016/j.cmet.2015.05.012

Alejandro Ocampo et al. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming, Cell (2016). DOI: 10.1016/j.cell.2016.11.052

Journal reference: Cell Cell Metabolism

Provided by: Cell Press

It's an exciting time to be an elderly mouse. Researchers believe that by removing senescent cells (cells with a persistent damage response), which naturally accumulate with age, senior rodents can regrow hair, run faster, ...

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A Mayo Clinic study has shown evidence linking the biology of aging with idiopathic pulmonary fibrosis, a disease that impairs lung function and causes shortness of breath, fatigue, declining quality of life, and, ultimately, ...

Scientists at the Gladstone Institutes discovered a key mechanism that protects mice from developing a human disease of aging, and begins to explain the wide spectrum of disease severity often seen in humans. Both aspects ...

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UNSW researchers have made a discovery that could lead to a revolutionary drug that actually reverses ageing, improves DNA repair and could even help NASA get its astronauts to Mars.

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Lacking EMTs, an Aging Maine Turns to Immigrants New York Times Now, thanks to an unusual program that is training immigrants to become emergency medical technicians, she is preparing to make better use of her medical background and, she hopes, work her way up to becoming a physician assistant if not, someday, ... and more »

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Lacking EMTs, an Aging Maine Turns to Immigrants - New York Times

Posted on March 24, 2017, 6 a.m. in Cancer Exercise

New study reveals that lactate, a molecule produced during intense exercise, plays a key role in cancer cell formation.

Medical researchers are on a quest to develop a comprehensive understanding of the mechanism that causes the process in which cells become cancerous. This process is known as oncogenesis. A recent study keys in on the molecule generated amidst intense exercise known as lactate. The purpose of this research is to explain lactate's role in the creation of cancer cells. The latest study's findings were published in the popular journal Carcinogenesis. About Lactate

Lactate is the byproduct of glycolysis, a chemical process that breaks apart sugar into smaller molecular components with the ultimate aim of generating energy. Lactate builds up in the blood and tissues when one engages in intense physical activity. If enough lactate accumulates, it can cause diminished physical performance as well as muscle tightness.

A famous German scientist named Otto Warburg first noticed that cancer cells consume an abundance of glucose compared to regular cells. Known as the Warburg effect, this phenomenon is a reference to the fact that cancer cells proceed through more glycolysis and generate more lactate than regular cells. The Latest Research

New research on this subject matter has been spearheaded by the director of the Sports Performance Department and physiology laboratory at the University of Colorado-Boulder's Sports Medicine and Performance Center. The director, Inigo San Millan, was determined to figure out why the Warburg effect occurs. Cancer research has deviated from cell metabolism study to genetics since Warburg's heyday in the early 20th century. However, the latest research might shift the spotlight back to lactate's role in the context of cancer development. Lactate and Oncogenesis

San Millan's research team suggests that lactate is the sole metabolic compound necessary and involved in the nearly half-dozen stages that stem from carcinogenesis. Their study analyzed the role of lactate in the process through which new blood vessels develop within tumors. This medical term for this process is angiogenesis. The study also examined the role of lactate in immune escape. This term refers to the cancer cells' eluding of the human body's natural immune responses. It also delves into the role of lactate in cell migration, self-sufficient metabolism, and metastasis.

San Millan's paper details how lactate assists in the creation of an acidic microenvironment outside of the cancer cell during metastasis. This phenomenon triggers the spread of additional cancer cells. The study also explores the connection between genetic components and lactate. The research team hypothesized that three transcription factors (p53, cMYC and HIF-1) common in the majority of cancers catalyze the deregulation of lactate. Can Halting Lactate Stop Cancer?

The important role of lactate in cancer cell creation helps explain why people who exercise on a regular basis have a low risk of cancer development. Individuals who exercise enjoy a body that is trained to transfer lactate to an energy source for the body, preventing an excessive accumulation of the metabolic compound. The findings allow for speculation that an idle lifestyle combined with an excessive consumption of sugar might lead to an abundance of lactate that leads to cancer. These findings show that lactate is not only present when cancer develops but required for each step of its development. What's Next?

San Millan hopes to team up with the University of Colorado Hospital to analyze the effects of custom tailored physical fitness programs created for cancer patients. At the moment, San Millan is studying the nuances of breast cancer cell lines. His hope is that additional research will ameliorate the quest to develop drugs that prevent the accumulation of lactate. These drugs will likely help key in on monocarboxylate transporters that transmit lactate between the body's cells.

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Lactate May Drive Cancer Development | Worldhealth.net Anti ... - Anti Aging News

An anti-aging therapy could be one step closer; in a new study, researchers reveal how a peptide led to the destruction of cells that play a role in aging, reversing fur loss, kidney damage, and frailty in mice.

The research describes how the peptide stops levels of a protein called FOXO4 from increasing in senescent cells, which are cells that lose the ability to replicate and destroy themselves, but which remain metabolically active.

Senescent cells accumulate with age, and studies have shown that they can contribute to the aging process by causing damage to neighboring cells and impairing tissue function.

Previous research has shown that in senescent cells, levels of FOXO4 rise to prevent another protein called p53 from prompting the cells' self-destruction.

By blocking FOXO4 with the peptide, the research team has been able to restore programmed cell death, or apoptosis, in senescent cells.

"Only in senescent cells does this peptide cause cell death," says senior author Peter de Keizer, a researcher of aging at Erasmus University Medical Center in the Netherlands.

"FOXO4 is barely expressed in non-senescent cells, so that makes the peptide interesting, as the FOXO4-p53 interaction is especially relevant to those cells, but not normal cells."

On administering the peptide to fast-aging mice in regular doses, the researchers were able to reverse age-related conditions, such as fur loss and poor kidney health.

The findings were recently published in the journal Cell.

For their study, the researchers tested the peptide on older mice that had aged naturally and mice that had been genetically modified to age rapidly.

Both groups of mice developed characteristics and health problems commonly associated with aging, such as loss of fur, a decline in kidney health, and frailty.

Some of the rodents in each group were given infusions of the peptide three times a week for 10 months, while the remaining mice were monitored as controls.

Both the fast-aging and naturally aged mice saw improvements with peptide treatment, with no apparent side effects.

Within 10 days, the fast-aging mice began to experience fur regrowth. After 3 weeks, the naturally aged mice began to see improvements in fitness, compared with mice that did not receive the peptide.

Additionally, both the fast-aging and naturally aged mice started to demonstrate improvements in kidney function from 1 month after peptide treatment.

The team notes that the effects of peptide treatment were was so strong in fast-aging mice that doses needed to be reduced over the study period.

The researchers say that their findings support previous research showing that targeting senescent cells can help to reverse aging and increase lifespan, though much more research is warranted.

"The common thread I see for the future of anti-aging research is that there are three fronts in which we can improve: the prevention of cellular damage and senescence, safe therapeutic removal of senescent cells, to stimulate stem cells - no matter the strategy - to improve tissue regeneration once senescence is removed," says de Keizer.

He and his colleagues now plan to conduct a clinical trial to assess the safety of the peptide in humans.

Learn how exercise prevents cellular aging by increasing mitochondrial capacity.

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Anti-aging peptide recovers fur growth, kidney health in mice - Medical News Today

Dr Lindsay Wu is a researcher and is taking anti-ageing pills. Pix of Dr Wu in his research lab. Pic Stephen Cooper

AUSTRALIAN scientists have discovered a vitamin, nicotinamide mononucleotide (NMN), that helps cells repair DNA damage and its so good they are taking the pill themselves.

The cells of the old mice were indistinguishable from the young mice, after just one week of treatment, said Professor David Sinclair of UNSW School of Medical Sciences and Harvard Medical School Boston.

The study showed middle-aged mice given the vitamin lived 20 per cent longer and were able to run faster.

This is the closest we are to a safe and effective anti-ageing drug thats perhaps only three to five years away from being on the market if the trials go well, says joint researcher Dr Lindsay Wu from the University NSW.

Sydney businesswoman Kate Johnson, 34, runs a natural lip gloss company and said she is keen to try the anti-ageing product when it hits the market.

Im only in my early 30s myself but I would look at something like that in the future, she said.

I know certain facets of the market would think its not natural and say you should age gracefully and Im a huge believer in ageing gracefully, but at the same time you shouldnt apologise for doing something that makes you feel happy or healthy.

This sounds like a drug that will be revolutionary for women who are fickle about ageing and want to load up on drugs to fight it. And (it will be used by) other women who just want another product, just like cleansing their face in the morning.

Dr Wu, aged 33, is not old, but says he has been taking the vitamin pill for a year.

I am using it, Im not supposed to take it but I feel just fine, there are no side-effects, he said.

I take it out of intellectual curiosity.

In a paper published in Science today, the researchers identify a critical step in the molecular process that allows cells to repair damaged DNA.

Research by University NSW scientists Prof Sinclair and Dr Wu into the substance won NASAs iTech competition in December last year because of its potential use in the planned 2025 mission to Mars.

Accelerated ageing caused by cosmic radiation, mental impairment and increased risk of cancer are pitfalls of space travel.

On a trip to Mars five per cent of the astronauts cells will die affecting their mental and physical capacity.

Its hoped this vitamin might be able to reverse that damage says Dr Wu.

Back on earth the medicine promises to help every human defy the ageing process and stay healthy and it has potential to overcome the terrible side effects of cancer radiotherapy and chemotherapy.

Its also been found to treat Type 2 diabetes and restore vision following eye damage in animals.

A separate Japanese study showed mice given NMN gained less weight with ageing even when they consumed more food perhaps because their boosted metabolism used more energy.

However, he said the general population should not use it until it has been property tested in clinical trials.

And when clinical trials are complete it wont be on the market to treat ageing, instead it is likely to be used as a therapy to treat the side effects of cancer radiotherapy.

The big problem is that regulatory authorities dont recognise ageing as a disease even though you lose memory, you lose movement and it gives you cancer, he says.

To get approved by the US Food and Drug Administration and Australias Therapeutic Goods Administration NMN will have to be registered to treat a recognised disease like the side effects of radiation.

Things could be about to change though. A US trial is underway to test whether the diabetes drug metformin can extend human life and prevent cancer because of evidence it expands lifespan in animals.

The makers of Metformin will be the first to push the FDA to recognise ageing, change is in the air, says Dr Wu.

The discovery of the vitamin developed out of research into the famed life extending qualities of the molecule resveratrol found in red wine.

HOW IT WORKS

NMN works on the same biological pathway as resveratrol.

Every time we go out into the sun our DNA is damaged but our body repairs the damage, however as we age our bodys ability to do the repairs declines, Dr Wu explains.

A vitamin Nicotinamide adenine dinucleotide (NAD+) present in every cell boosts the bodys ability to repair cells but it declines by 60 per cent as we age or when we are exposed to radiation.

If you can boost NAD+ you can boost DNA repair, he says.

The research found that if you treated mice with a NAD+ precursor, or booster, called NMN it improved their cells ability to repair DNA damage caused by radiation exposure or old age.

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Revolutionary anti-ageing drug makes you look younger and live longer - Perth Now

BROOKHAVEN >> Slightly under two years ago, Dr. Jason Weigner, DC, opened Discover Optimal Healthcare at 3605 Edgemont Ave. to offer patients an alternative to the common separate health care system that, he said, is often extremely costly and ineffective.

Rather than expecting patients to manage their own care and go from facility to facility to visit a medical doctor, a chiropractor, a physical therapist and other health care professionals, all while treating the same injury or condition, Discover Optimal Healthcare offers all of the professionals under one roof for the patients welfare, convenience and to coordinate their entire care as a team. Weigner said that each health care professional is a vital part of the integrated health care team that works together to get a patient out of pain quickly and permanently, without resorting to surgery and other invasive methods.

Weigners state-of-the-art facility has more than 4,000 square feet of clinical office space and some of the most modern rehabilitation and diagnostic equipment. Services there include chiropractic care, regenerative and physical medicine, rehabilitation services, medical weight loss, anti-aging services, massage and acupuncture. Discover Optimal Healthcare treats a patient with individualized support in four progressive stages by relieving their pain, correcting the pains cause, strengthening the patients body and maintaining their wellness.

Discover Optimal Healthcare has a multi-specialized staff of 18, including Dr. Jason Weigner, DC; Dr. Mary Kashurba, MD; Barry Greenfield and Aubrey Brumanti, physicians assistants; Dr. Anthony Odell, DC; and Dr. Greg Parsons, DC.

According to Weigner, Discover Optimal Healthcare offers non-invasive yet aggressive treatment plans to restore and enhance physical functions and quality of life for all patients. The facility specializes in treating a wide variety of spinal and joint conditions including neck and back pain, headaches, knee and hip pain, sciatica and scoliosis, sports, auto and work injuries, neuropathy, whiplash, Fibromyalgia and Carpal Tunnel Syndrome. Discover Optimal Healthcare also offers a medical weight-loss program, hair restoration treatments and an anti-aging med spa with Botox and fillers.

Traditional medicine alone cannot compare with the combined knowledge, specialization and care offered by a team of doctors and medical professionals who collaborate and work together in physical and regenerative medicine, Weigner explained. We can get patients back to a pain-free life sooner and keep them healthier longer by fixing their underlying problems so they can start living fully again, rather than just treating their symptom.

As a pioneer in a new, cutting-edge treatment option, Weigner recently introduced stem cell therapy to his patients.

This new therapy option treats arthritis, nagging joint pain, neuropathy, back and neck pain, cartilage and muscle issues and a host of other conditions, repairing and regenerating joints all without the need for painful, invasive surgery, Weigner said excitedly. After even one stem cell treatment, many of our patients experience noticeable relief from the pain that had kept them from living their best life.

Weigner said stem cell therapy has about a 75 to 85 percent success rate if a patient is a candidate for this type of treatment.

The patients who have success with stem cell therapy love the fact that they regain their lives and get out of pain quickly without the risks of invasive surgery and the complications, anesthesia and intensive rehabilitation that come with going the traditional surgical route, Weigner explained.

Weigner said that stem cell regeneration therapy utilizes adult stem cells that are derived from fat and bone marrow harvested along with cryo-preserved umbilical cord stem cells as an additional option for some individuals. This is a non-controversial and non-harmful way to unleash the power of stem cells and gain additional growth factors, he said.

According to an explanation on Weigners website, Human body cells are constantly going through a regenerative and degenerative process. The regenerative cells are derived from stem cells. Stem cells possess the ability to duplicate into other cells. This means that if you have structural or degenerative damage in your knee, stem cells introduced to the area will join with the other knee cells to regenerate or rebuild the damaged area. These cells will streamline the healing process and help patients recover rapidly from serious injuries, without going under the knife. Stem cell therapy is a minimal pain (only the prick of a needle) and completely non-invasive alternative to regular surgery. Stem cell injections are placed in the area of need, using arthroscopic and ultrasound guided monitoring procedures to ensure that stem cells reach the area most in need of regeneration. Simple shots can begin to rebuild the area and return normal function, mobility and comfort levels to the patient.

Weigner said he believes that stem cell therapy is the future of medicine and can help cure everything from plantar fasciitis to deteriorating joints and can even stimulate hair growth. To answer questions and spread the word about stem cell therapy, Weigner offers free community education workshops. He advertises the events on the Discover Optimal Healthcare Facebook page, as well as in local newspapers.

Discover Optimal Healthcare, the winner of Best of Delco awards for three consecutive years, offers free consultations for any condition. Weigner said if his facility cannot help certain patients for various reasons, the team will immediately refer them somewhere else to get the help that they need. The staff at Discover Optimal Healthcare is warm and friendly, he said, and prides itself on treating everyone like family.

We have at over 40 different five-star reviews and testimonials on our website, Weigner said proudly. We treat everyone with respect and compassion, with the same care and motivation to helping them as if they were our family. Our patients tell me again and again what a great team we have here.

Weigner says that he cant help but be enthusiastic over how many patients he has helped with the newest brea-throughs in stem cell therapy.

At Discover Optimal Healthcare, we are pleased to bring hope to the hopeless by offering all of our patients an opportunity to take advantage of, what I think, is the most significant medical breakthrough in natural medicine in this decade, Weigner stated. Theres nothing better than helping patients with this new, alternative therapy to rediscover a life free of pain.

For more information on Discover Optimal Healthcare at 3605 Edgemont Ave., Brookhaven, stem cell therapy or to book a free consultation, call 610-876-6180 or visit http://www.dohealth.net

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Discover Optimal Healthcare in Brookhaven offers patients alternative to surgery - Delco News Network

PureTech will take on the development of two mTORC1 inhibitors from Novartis aimed at stopping the decline of the immune system associated with age.

Novartis is building up the portfolio of PureTech is a Boston-based healthcare company listed on the London stock market. Originally an investment firm, it now has put together a drug pipeline from its biotech portfolio. Its latest additionsare twodrugs to prevent and treat diseases related toimmunosenescence, an age-related process that reduces the immune systems functions.

PureTech will create a subsidiary, resTORbio, to carry out the development, starting with a Phase IIb trial for age-related immune system deterioration. The US company has allocated 14M ($15M) for the program, giving it a 58% stake that could rise to 67% in the future with an additional 9M ($10M) investment.

For its part, Novartis will get an undisclosed equity stake in the company plus milestonepayments and royalties as the drug advances through development and commercialization. The big Swiss pharma has already run two Phase IIa studies in elderly patients with the two mTORC1 inhibitors.

The immune system progressively loses its function with age, leading to age-related disorders

Novartis already has an mTOR inhibitor in the market, Everolimus, used as an immunosuppressant for organ transplantation and certain forms of cancer. Preclinical research seemed to indicate that this drug could also extend the lifespan and boost the efficacy of vaccines, which led the company to start human trials.

However, despite the promising potential of the candidates, Novartis has decided to trust someone else with developmentand waitto see whether theyre successful in the long term.

The field ofanti-aging,focused on delaying and preventing age-related conditions, is still young and so far it mostly attracts innovative biotech companies rather than traditional pharma. But as medicine advances and the human lifespan increases, Im sure it will start gaining more and more recognition.

Images from Africa Studio /Shutterstock;Dorrington MG and Bowdish DME (2013)Front. Immunol. 4:171.

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Novartis puts the Development of two Anti-Aging Drugs in American Hands - Labiotech.eu (blog)

Posted on March 23, 2017, 6 a.m. in Depression Alternative Medicine Exercise

Study finds that yoga classes accompanied by home practice lead to a significant reduction in symptoms of depression.

Depression is a mental health condition that affects the brain and often begins in early adulthood. According to the Anxiety and Depression Association, more than 15 million Americans were identified as suffering from depression in 2016. Although anyone at any age may suffer from depression, its more common in women.

Depression is recognized as a distinct condition and treatments range from drugs to psychotherapy, to lifestyle choices. Most antidepressant drugs work to change the chemical reactions occurring in the brain. While the drugs each work in a slightly different way, they are each intended to balance neurotransmitters. Many people are successfully treated with these drugs.

Unfortunately, however, not all drugs work. Some individuals experience side effects, while others simply dont want to take drugs, and some dont find any relief from their symptoms. Doctors and researchers have worked for years to find alternative ways to treat depression. Diet, exercise, counseling, and supplements are some of the alternatives being explored. Another alternative is yoga.

In a recent study reported in the Journal of Alternative and Complementary Medicine, individuals who participated in yoga classes at least twice a week and practiced additionally at home, experienced a decrease in their symptoms. Specifically, this study used lyengar yoga which is a practice that works to improve strength, mobility and balance. Particular attention is given to breath control known as pranayama. The poses or asanas used during practice all work to accomplish the lyengar goals.

Participants in the study were broken into two groups. One group participated in 90-minute yoga classes three times a week, while the other group practiced 90 minutes twice a week. Both groups were advised to additionally practice at home. Each group contained clients who were taking prescription antidepressants as well as those who did not. At the end of the study, both groups reported an overall decrease in symptoms. This held true for those who were on antidepressants as well as those who were not.

While drug therapy may be a viable option for some, a yoga alternative seems to offer substantial relief to individuals suffering from depression without to risk of side effects or harmful drug interactions. The good news for people suffering from depression is that yoga offers them an additional choice about treatment.

Chris C. Streeter, Patricia L. Gerbarg, Theodore H. Whitfield, Liz Owen, Jennifer Johnston, Marisa M. Silveri, Marysia Gensler, Carol L. Faulkner, Cathy Mann, Mary Wixted, Anne Marie Hernon, Maren B. Nyer, E. Richard P. Brown, John E. Jensen. Treatment of Major Depressive Disorder with Iyengar Yoga and Coherent Breathing: A Randomized Controlled Dosing Study. The Journal of Alternative and Complementary Medicine, 2017; DOI: 10.1089/acm.2016.0140

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Yoga for the Blues - Anti Aging News