Author Archives: Fredricko

Grey’s Anatomy Recap: Stephanie Steps Up and Meredith Moves On – Cosmopolitan.com

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All I could think about during last night's episode of Grey's Anatomy is how it will feel to watch the series if the Affordable Care Act is fully repealed. To be very clear: I know there are far worse consequences of the bill than its impact on TGIT programming. Thousands will sicken and die. I could easily be one of them. All I'm trying to do is illuminate the lens through which I was watching the episode. And to be even clearer: The repeal isn't set in stone yet. Keep calling, keep writing, get louder.

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To be fair, Grey's has always shied away from delving too deeply into the financial lives of its patients (they've been all too eager to dig into the financial health of the hospital though). We don't see patients frantically paging through bills once they've been discharged or calling their insurance companies to get procedures cleared. But it bears mentioning that the show's two most memorable episodes about financial hardship for patients both aired during the Bush administration: Joe the bartender's inability to pay for his expensive brain surgery and Ryan, the young boy who "trick or treated" for doctors and nurses to staff a pro bono surgery to give him ears. (Sidebar: That little boy grew into Dylan Minnette, who played Clay in 13 Reasons Why. What is time!?!?)

As the Affordable Care Act was rolled out, Grey's wove subtle references to it into its storytelling. At least one character talked about Obamacare specifically, and others mentioned finally being able to afford health care, or getting ongoing health issues checked out now that they were insured. So if Grey's wants to continue acknowledging America's health-care landscape next season, what would that even look like? Arizona performing a fetal surgery only to have to immediately stop because the baby's reached its lifetime limit already? Owen turning patients away from the emergency room? Doctors playing fast and loose with diagnoses so as to not document pre-existing conditions on patients' charts? SHOULD BE PRETTY FUN TO WATCH.

Anyway, it's not a great reflection on last night's episode that I had plenty of time in which to obsess over how the series might reflect our political climate a year from now, but here we are. I cannot get past my case of "She doesn't even go here!" when it comes to Eliza, and I'm frustrated that she continues to be used as a plot device rather than a person. She kisses Arizona! She meddles with residents! Who is she? GREAT QUESTION, NO ONE KNOWS.

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It's especially frustrating when she decides that Ben doesn't take enough risks as a surgeon. This is a dude who literally did a C-section on a kitchen table and who was ballsy enough to take point in a room full of squabbling surgeons, like, three episodes ago, so I'm not sure what more he's supposed to be doing. One-handed surgery? Blindfolded, perhaps? He's always been confident, so this feels more like the writers trying to back-door justify why he hasn't necessarily had much to do this season.

Eliza's meddling doesn't stop there. ("Meddling" is probably unfair, because she literally is just doing her job, but she's doing a very, very, very, very, very confusing/irritating version of it.) She places herself squarely in the middle of a case of Alex and Stephanie's as they try to care for a young boy with a brain tumor whose parents are declining medical help for religious reasons. Alex is back to being his "Karev, Defender of Tiny Humans" self in a pretty awesome way, but Eliza gets right into the thick of it, telling him that he of all people should be "following the letter of the law" right now. Dude, ONLY MEREDITH CAN TALK TO ALEX THAT WAY. Or possibly Bailey. Alex and Stephanie play fast and loose to treat the child without his parents' consent. They save his life, but Stephanie loses her surgical privileges after chucking an iPad at the father's head. It is incredibly satisfying to watch.

In the middle of all of that business, Eliza tells Arizona that she has "naked plans" for her later, which is maybe the least sexy way I've ever heard a person invite someone to hook up. I'm all for Arizona getting hers! Just don't call it that. Arizona has a patient and can't make their sex date, so she and Eliza flirt and sexy tease each other in an elevator. Sorry, Eliza, but you have to earn elevator sexcapades. They do wind up having sex at the end of the episode and it's fine, whatever, sure, but it's just another moment that cements Eliza's status as a plot device, not a person.

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Also, Maggie attempts a heart surgery that's basically impossible (and ultimately fails) to help her cope with her feelings about Meredith and Riggs? Or something?

This week, the early stage of Meredith's relationship with Riggs continues to be almost unbearably drawn out, but I was too worried about losing my health insurance and maybe dying to be too annoyed by it. Congratulations, everyone! We did it! Meredith starts putting pieces of her relationship with Derek aside to make room, literally and figuratively, for Riggs. She takes down the diagram of a spinal tumor that Derek once drew on her walls; she puts the Post-it note vows in a drawer.

It's an important moment in Meredith's healing process, and giving the tumor drawing to Amelia might mend the resentment she has toward Meredith for not calling her to Derek's deathbed to say good-bye. (Amelia hasn't brought it up in a while, but you know it's still been festering.) But goddamnit, it still hurts to see her tuck away reminders of her past with Derek. As time has gone on, I don't miss Derek as, essentially, Meredith's manic pixie dream boy. But the tumor picture and the Post-it vows show how fun it was to watch them when they were when truly a couple, working alongside one another. I miss that. Riggs and Meredith finally leave the hospital hand-in-hand at the end of the episode, so I'll say what I have been saying in at least six recaps this season: I guess they're finally going to really go for it now!

Also, Deluca tries to profess his love for Jo and I'd love to tell you more about that, but the second it started happening, I fell into a deep, deep sleep. WAKE ME UP WHEN SHE HAS A CONVERSATION WITH ALEX.

Follow Lauren on Twitter and Cosmo Celeb on Facebook.

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Grey's Anatomy Recap: Stephanie Steps Up and Meredith Moves On - Cosmopolitan.com

Gene Drive Research in Non-Human Organisms …

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Welcome to theNational Academies of Sciences, Engineering, and Medicine study that examined a range of questions about gene drive research.The study wasconducted by acommittee of expertsand released June 8, 2016.

Gene drives are systems of biased inheritance that enhance the ability of a genetic element to pass from an organism to its offspring through sexual reproduction. A wide variety of gene drives occur in nature. Researchers have been studying these natural mechanisms throughout the 20th century but, until the advent of CRISPR/Cas9[1] for gene editing, have not been able to develop a gene drive.

Since early 2015, laboratory scientists have published four proofs-of-concept showing that a CRISPR/Cas9-based gene drive could spread a targeted gene through nearly 100% of a population of yeast, fruit flies, or mosquitoes. Biologists have proposed using gene drives to address problems where solutions are limited or entirely lacking, such as the eradication of insect-borne infectious diseases and the conservation of threatened and endangered species. This study provided an independent, objective examination of what has been learned since the development of gene drivesbased on current evidence.

The resulting report, Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to gene drive research and the governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.

Follow on Twitter:#GeneDriveStudy

Send email to:ksawyer@nas.edu

[1] CRISPR (Clustered regularly-interspaced short palindromic repeats) are segments of bacterial DNA that, when paired with a specific guide protein, such as Cas9 (CRISPR-associated protein 9), can be used to make targeted cuts in an organisms genome

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Gene Drive Research in Non-Human Organisms ...

Red Wine Antioxidant Might Help Diabetics’ Arteries – Sioux City Journal

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THURSDAY, May 4, 2017 (HealthDay News) -- The antioxidant resveratrol -- found in red wine, peanuts and berries -- might improve the health of blood vessels in people with type 2 diabetes, a small study suggests.

The study found that resveratrol supplements lessened artery stiffness in some people with type 2 diabetes. Stiffening of the arteries, called arteriosclerosis, raises the risk of heart attack and stroke.

"In treatment with resveratrol among people with diabetes, there was a trend toward improvement in the stiffness. And in people with higher stiffness there was more of a benefit," said lead researcher Dr. Naomi Hamburg. She is chief of the vascular biology section at Boston University School of Medicine.

While the research suggests there might be ways to improve blood vessel abnormalities in people with type 2 diabetes, it's too soon to recommend resveratrol for that purpose, said Hamburg.

"We would need a longer study to look at whether this is going to reduce heart attacks and stroke," she added. "But I think this is evidence to support future research."

For now, Hamburg said, "the overall recommendation is to have a diet that's rich in fruits and vegetables."

As you age, your arteries stiffen, which can lead to an increased risk of heart disease. In people with type 2 diabetes and obesity, this process starts earlier and can have more severe consequences, she said.

The body's largest artery is the aorta, which carries blood from the heart toward the rest of the body. For the study, the researchers measured the aortic thickness of 57 patients with type 2 diabetes (age 56 and obese, on average). The investigators also conducted tests to measure blood-vessel health.

Some patients were given resveratrol supplements, while the others were given a placebo. Overall, the study found a trend toward less aortic stiffness in participants taking resveratrol supplements, but it wasn't statistically significant.

However, in a subset of 23 patients who had an exceptionally stiff aorta at the start of the study, 100-milligram (mg) daily doses of resveratrol for two weeks reduced stiffness nearly 5 percent. That regimen was followed by 300-mg doses over two weeks, which decreased stiffness by 9 percent, the researchers said.

Aortic stiffness increased among those taking a placebo for four weeks, the researchers found.

In animal studies, Hamburg said, resveratrol has been shown to activate a gene (SIRT1) that appears to delay aging and development of several diseases.

To see if the same thing would happen in humans, the same researchers took samples from the blood-vessel linings of seven patients and looked at SIRT1 activity. They found that gene activity increased slightly after resveratrol supplementation.

This doesn't prove that reservatrol activates the longevity gene, only that there was an association. Still, another scientist welcomed the new findings.

"We know that people who drink red wine and eat nuts live longer, but why?" said Dr. Byron Lee, a professor of medicine at the University of California, San Francisco. "It's exciting to see scientists now starting to unravel this mystery."

This study shows that a natural antioxidant in these foods can reverse age-related changes in the arteries, said Lee, who wasn't involved in the study.

"Impressively, the effect was seen after just a few weeks of treatment. Who knows what more prolonged antioxidant treatment could do to the arteries and other organs," he said.

Many people obtain resveratrol in their daily diet. However, Hamburg pointed out that the doses of resveratrol used in the study were much greater than exists in a glass of red wine, a major dietary source of the antioxidant.

The study was funded by the U.S. National Heart, Lung, and Blood Institute and the U.S. National Center for Complementary and Integrative Health.

The results were scheduled for presentation Thursday at a meeting of the American Heart Association, in Minneapolis. The research should be considered preliminary until published in a peer-reviewed medical journal.

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Red Wine Antioxidant Might Help Diabetics' Arteries - Sioux City Journal

Maine Compass: Flame retardants an example of better living through chemistry gone awry – Kennebec Journal & Morning Sentinel

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The Maine Legislature are considering L.D. 182, a bill with the goal of eliminating the chemical treatment of furniture to prevent fires. What? Are the folks behind this bill against safety? Actually, no just the opposite is true.

The history of this practice dates back to the 1960s, when chemical flame retardants were first invented for industrial use. Someone in California later had what seemed like a great idea. Since house fires were often triggered by cigarettes igniting furniture, couldnt we treat household upholstery to slow down the burn? The chemical manufacturers helped promote the idea to the state legislature, and a bill passed that established California standards for furniture treatment, which ended up being used nationally, since California is such a big market. California, by the way, rescinded the bill about five years ago because of toxicity concerns.

The worst flame retardants PDBEs were voluntarily discontinued by the chemical industry around a decade ago. Multiple animal studies documented an association between exposure to these molecules and imbalance in the delicate regulation of both the sex hormone and thyroid systems. Human exposure was tied to pregnancy complications, birth defects, and lower IQ scores. Their chemical properties put them in the category of endocrine disruptors able to interfere with the basic pathways in our cells that regulate body balance. Endocrine disruptors also are thought to be contributing to the obesity epidemic and the increase in type 2 diabetes.

The chemicals that have replaced PDBEs, unfortunately, have similar molecular structures and similar metabolites and are associated with the same toxicities.

Fire retardants work by either inhibiting the process of oxidation chemically (remember: burning is oxidation) or by having the materials form a char, creating a physical block to burning. This all makes sense, perhaps, if a cigarette really is the source of ignition. If the fire starts in the homes electrical system or stove, however, the addition of retardants delays the burning of the couch by 20 to 30 seconds, max. Tighter fabric weaves have the same effect.

It is remarkable how much of these chemicals are added to upholstery up to 5 percent by weight. They are not chemically bound to the furniture component, and can off-gas and be inhaled, or migrate to the surrounding indoor environment and become part of house dust. Old furniture ends up in landfills, leading to dispersion of these materials in the outdoor environment. All of us have measurable amounts in our bodies. American levels are much higher than European, because we put so much more into our furniture than they do overseas.

Worldwide, more than 4 billion pounds are produced yearly, leading to substantial environmental contamination. Because these substances are bio-accumulative, they make their way into soils, then up the food chain with subsequent storage in animal tissues. Levels in breast milk have increased 100 fold since the 1970s. Even North American polar bears have measurable blood levels with reproductive effects presenting another challenge to their survival on top of the disintegrating ice pack.

As a pediatrician, I am most concerned about their developmental impact on children, who are playing on the floor, more in contact with house dust, and mouthing their hands and toys. There is another group, however, who may be more at risk of toxicity than kids our volunteer and professional firefighters. When burned, fire retardants tend to form dioxins, a class of compounds that are known potent carcinogens. One of the replacement chemicals is TRIS, which was removed from infant sleepwear decades ago because of cancer concerns. While our firefighters wear protective equipment, repeated exposures on the job are inevitable.

Firefighters feel that the 20- to 30-second delay to the time that the couch or mattress catches fire does little to help them save lives or property. At the February legislative hearing on L.D. 182, the head of the state firefighters organization described his experience in losing friends to cancer, and argued passionately in favor of passage of the bill. The bill itself is titled An Act to Protect Firefighters though pediatricians would not object to adding kids to that title.

Both organizations that I represent the Maine Chapters of Physicians for Social Responsibility and the American Academy of Pediatrics would urge our legislators to support this bill. Flame retardants are like the lead we used to put in gasoline an example of better living through chemistry gone awry. They provide little or no benefit, contaminate our environment, and cause substantial harm.

Sydney R. Sewall, M.D./MPH, has been a pediatrician in Augusta for more than 30 years. He lives in Hallowell.

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Maine Compass: Flame retardants an example of better living through chemistry gone awry - Kennebec Journal & Morning Sentinel

Chemistry teacher charged with fleeing from police, other counts – Scranton Times-Tribune

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A chemistry teacher from the Carbondale Area School District faces charges after police said he drove an all-terrain vehicle erratically on Old Forge streets, threatened another motorist with a firearm and refused to speak to officers investigating the initial allegations.

Police charged Ross Gerald Merieski, 35, 1247 Mowery St., Old Forge, with misdemeanor counts of fleeing from a police officer, resisting arrest and disorderly conduct as well as a long list of driving offenses.

Old Forge Police responded about 8 p.m. Sunday to a Main Street car wash, after someone called 911 to report a man on an ATV had shown a handgun to another motorist there after a confrontation over his driving.

When the officer located a man driving an ATV who fit the witnesss description and pulled his squad car alongside the vehicle, Merieski responded to the officers request to talk by saying Im not getting fined and this is Old Forge, not Scranton before speeding off, according to the police report.

The officer followed Merieski in his squad car until the suspect retreated to the ATV trail off of Pittston Avenue, threatening to drive away if the officer came closer. The officer tried to approach on foot and question the man, but retreated when he saw the suspect was armed.

Im from Old Forge, the man repeatedly yelled, according to the police report.

The officer then went to interview two witnesses outside a bar, who identified the man as Merieski, a former teacher of theirs at Old Forge High School. While there, the suspect drove his ATV past and gestured with his arm, though the officer could not determine what the gesture was, he wrote in the report.

Once backup arrived, the three officers chased the man briefly, who accelerated to speeds exceeding 50 mph while ignoring several stop signs.

The trio of officers broke off and went to his home to wait for him. He eventually approached on foot and they arrested him.

At the Old Forge Police Headquarters, the officers detected a strong smell of alcohol on him, according to their report.

When they asked him to write a statement, he became aggressive, telling officers he was a chemistry teacher and had work in the morning.

Charge me already and send me home, he said, according to the police report.

He was released on $15,000 unsecured bail. A preliminary hearing is scheduled for Monday.

Asked if Merieski had been disciplined, the Carbondale Area School District said it had put a professional employee on administrative leave this week, but would not comment further because its a personnel matter, business manager David Cerra said.

Contact the writer:

pcameron@timesshamrock.com, 570-348-9100 x5365,

@pcameronTT on Twitter

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Chemistry teacher charged with fleeing from police, other counts - Scranton Times-Tribune

Puma Biotechnology (PBYI) Stock: Falling Hard On Robert Charnas Resignation – CNA Finance (press release)

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Puma Biotechnology Inc (NASDAQ: PBYI) is having an overwhelmingly rough start to the trading session this morning, and for good reason. Early this morning, it was announced that a key member of the management team will be leaving the company. As a result, fear struck investors, leading to declines in the stock. Of course, our partners at Trade Ideas were the first to alert us to the declines in the stock. Currently (9:12), PBYI is trading at $32.00 per share after a loss of $4.55 per share or 12.45% thus far today.

As mentioned above, Puma Biotechnology is having an overwhelmingly rough day in the market today after investors learned that a key executive has made the decision to leave the company. Early this morning, it came to light that on April 28th, Robert Charnas, senior vice president of regulatory affairs and project management, notified the company that he will be resigning for health reasons.

Of course, this is overwhelmingly bad news. After all, PBYI isn't the source of the health issues that forced the resignation, but they are sure going to deal with the pain associated with a key member of the team leaving.

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Moving forward, the CNA Finance team will be keeping a close eye on PBYI. In particular, we're interested in following the company to see who takes on the position that Charnas will leave. Nonetheless, we'll continue to follow the story closely and bring the news to you as it breaks.

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Puma Biotechnology (PBYI) Stock: Falling Hard On Robert Charnas Resignation - CNA Finance (press release)

Woodrey: Anatomy Of A Closer | D1Baseball.com – D1 Baseball College Baseball News & Scores

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Columns Thomas Woodrey - May 4, 2017

For as bad of a wrap as lefthanded pitchers get, closers definitely take the cake as the most unique players in the game. No two closers are the same, and no one style is better than the next. In my time at the University of Miami, I got to experience several unique personalities as they attacked the role. Theres both a mental and physical component to being a closer, and I am going to dissect just what it takes to excel in each area.

Its the bottom of the ninth and your team is up one run. The opposing team has been building momentum, and you need to close it out and secure the win. So who do you bring in: the crazy, hyped up closer who has been chirping at the other team from the dugout all game, or the locked in reliever that has been visualizing in the corner of the dugout all game? Trick question! It doesnt matter.

The majority of my career I had the extreme pleasure of watching Miamis current all-time saves leader, and 2016 Stopper of the Year, Bryan Garcia. Garcia was a fierce competitor maybe the best I have ever seen in my years of baseball. Many others on the team shared in this opinion, as was evident from him being voted team captain as both a sophomore and then again as a junior before foregoing his senior year to play pro ball for the Detroit Tigers. When game time rolled around, Garcia would mentally lock in.

The mental side of the game I think is what separates closers, Garcia explained. There are so many closers that have incredible stuff, but when a situation gets difficult the game seems to speed up on them. Before they know it the lead is gone.

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Tesla battery researcher unveils new chemistry to increase lifecycle at high voltage – Electrek

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Electrek
Tesla battery researcher unveils new chemistry to increase lifecycle at high voltage
Electrek
Those are already pretty good results, but Tesla aims to do better with Jeff Dahn, a renowned battery researcher and the leader of Tesla's research partnership through his battery-research group at Dalhousie University. The scientist and his team ...

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Tesla battery researcher unveils new chemistry to increase lifecycle at high voltage - Electrek

Northeast Financial Consultants Inc Sells 650 Shares of iShares NASDAQ Biotechnology Index (IBB) – The Cerbat Gem

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Northeast Financial Consultants Inc Sells 650 Shares of iShares NASDAQ Biotechnology Index (IBB)
The Cerbat Gem
iShares NASDAQ Biotechnology Index logo Northeast Financial Consultants Inc cut its stake in shares of iShares NASDAQ Biotechnology Index (NASDAQ:IBB) by 48.1% during the first quarter, according to its most recent disclosure with the Securities and ...
iShares NASDAQ Biotechnology Index (IBB) Shares Bought by Beaumont Financial Partners LLCTranscript Daily
iShares NASDAQ Biotechnology Index (IBB) Upgraded to Buy at Vetr Inc.Markets Daily
iShares NASDAQ Biotechnology Index (IBB) Stake Maintained by Barrett Asset Management LLCSports Perspectives
BBNS -Community Financial News -Chaffey Breeze
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Northeast Financial Consultants Inc Sells 650 Shares of iShares NASDAQ Biotechnology Index (IBB) - The Cerbat Gem

Anatomy of a Price Gouging Case – JD Supra (press release)

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Anatomy of a Price Gouging Case - JD Supra (press release)

‘Grey’s Anatomy’ Sneak Peek: Alex Battles Eliza Over a Kid’s Rights – Yahoo TV (blog)

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When it comes to the kids under his care, Dr. Alex Karev is as protective as a mama bear with her cubs. And as Greys Anatomy fans have seen before, hes willing to toe lines or even cross them to give them the best care.

But in this sneak peek from Thursdays new episode, Alex (Justin Chambers) runs into a new force of opposition Eliza Minnick (Marika Dominczyk). A boy named Liam comes into the hospital with a tumor, but his parents refuse surgery due to their religious beliefs.

The kid took a train all by himself to ask us for help, Alex pleads toEliza. Actual help, not prayers and olive oil on his head.

Eliza doesnt back down. No neurosurgeon will cut into a kids skull without parental consent, because its illegal, she replies.

And then, twisting the knife a bit, she notes that with his history assaulting DeLuca and almost going to prison for it perhaps he shouldnt be crossing any lines right now.

Greys Anatomy airs Thursdays at 8 p.m. on ABC.

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'Grey's Anatomy' Sneak Peek: Alex Battles Eliza Over a Kid's Rights - Yahoo TV (blog)

‘Grey’s Anatomy’ Finale Has ‘Big News’ for Meredith & Riggs, and … – Moviefone

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The "Grey's Anatomy" Season 13 finale should bring major updates on at least two relationship fronts, in addition to major events at the hospital itself.

"Grey's" hasn't given us much on Alex Karev (Justin Chambers) and Jo Wilson (Camilla Luddington) in a while, but that will soon change. The synopsis for the May 18 season finale mentions Alex making a "hard choice" in his relationship with Jo. In the same episode, we'll see Meredith Grey (Ellen Pompeo) share some "big news" with Nathan Riggs (Martin Henderson), bringing their relationship to "a turning point."

(!) She's not pregnant again, is she?

The finale is Episode 24 and, at this point, Episode 22 has yet to air. Here are the titles and synopses for the final three episodes of the season:

"Leave It Inside," Episode 22 (May 4) "April and Andrew consult with a fiery patient who has a giant, inoperable heart tumor. Meanwhile, Alex and Eliza are at odds over the treatment of a young patient, and Stephanie and Ben make decisions that could affect their careers."

"True Colors," Episode 23 (May 11) "The doctors of Grey Sloan encounter a difficult case involving a dangerous patient. Meanwhile, Owen receives life-changing news that pushes Amelia to step up to support him, and Alex attends a medical conference after making a shocking discovery."

"Ring of Fire," Episode 24 (May 18) "The doctors' lives are at risk after a dangerous patient escapes the hospital room. Alex must make a hard choice in his relationship with Jo while Meredith has some big news for Nathan that brings things to a turning point."

So Alex will make a "shocking discovery" in the episode before the finale's hard choice about Jo. Don't forget that Matthew Morrison was seen with Justin Chambers when they were filming Episode 23 -- both wearing suits -- and Morrison is still being eyed as Jo's abusive estranged husband. There's a good chance Morrison's character, Dr. Paul Stadler, plays into Alex's hard choice about Jo. And, yeah, he's probably at this same conference.

The Season 13 finale sounds pretty intense, beyond whatever happens on the relationship fronts. A dangerous patient on the loose is bad, and may be part of the "shocking" event Kelly McCreary (Maggie) talked about.

"Grey's Anatomy" airs Thursdays at 8 p.m. on ABC.

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'Grey's Anatomy' Finale Has 'Big News' for Meredith & Riggs, and ... - Moviefone

Gene sequencing at Yale finding personalized root of disease; new center opens in West Haven – New Haven Register

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WEST HAVEN >> Our genes define our individuality, including what diseases to which we may be susceptible.

In just a few days, gene-sequencing machines can map all of a persons genes, revealing the cause of a genetic illness and even suggesting the best possible treatment.

On Monday, the Yale School of Medicine, partnering with Yale New Haven Hospital, took the next step toward personalized medicine, cutting the ribbon on its Center for Genome Analysis on Yales West Campus.

Dr. Murat Gunel, professor of genetics and neuroscience in the medical school, gave a vivid example of how gene sequencing can save lives:

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About three months ago a baby was born in New Haven with a really, really significant skin disease that we had to transfer him to the intensive care unit. And he was dying, and we didnt know what was wrong with him, Gunel said. In six days we were able to sequence his genome, understand his disease and he is at home playing with his mother now.

The baby suffered from dystrophic epidermolysis bullosa, which makes the skin extremely fragile, and its caused by a mutation in just one gene: COL7A1. Gunel said Dr. Keith Choate first saw the baby on a Saturday and by Friday had the diagnosis. This is a daily occurrence, Gunel said.

Choate said the genetic analysis showed the infant had a mild case of the disease, which was limited to the hands and feet. He is receiving advanced wound care, Choate said.

The pair of NovaSeq 6000 gene-sequencing machines that are churning out this information with three more on the way will help researchers find treatments and cures for cancers, prenatal diseases and others at a faster and faster pace.

Of 20,000 genes in the human genome, 57 have been identified for which preventive measures can be taken or treatment can be prescribed if an abnormality or mutation is found. For example, mutations in the BRCA1 or BRCA2 genes increase a womans risk of developing breast or uterine cancer.

We are sequencing every cancer at Smilow now, understanding what is specific for that cancer and giving treatment specific to that individual, Gunel said. We want to take from these specific diseases not only for prenatal, not only for newborn, not only for cancer, but [to] understand the health of an individual. We want to make Connecticut the healthiest state in the nation by sequencing and understanding the differences between all of us.

Dr. Robert Alpern, dean of the Yale School of Medicine, said, The idea is that you can know the total sequence of a patient and then follow their history, their health, what happens to them and then correlate them together so that someday we will be able to predict everything about ones health just from their DNA sequence.

Yale has done so much for New Haven, so much for New Haven County and now so much for this country, said Senate Republican President Pro Tem Len Fasano of North Haven.

Referring to the ability to map a persons genome within days, Fasano said, You can take that and figure out how the environment affects different lives by looking at different gene structure, comparing to different parts of the country or whether its an urban area versus a suburban area. The research that can stem from this is pretty amazing when you think of it.

The growing field also is a boon to the states economy. Senate Democratic President Pro Tem Martin Looney of New Haven said, This commitment to the advancement of health and medicine will have far-reaching and positive impacts on our economy and overall well-being for years to come. We know were going to need data scientists, health information specialists, clinical analysts, genomic counselors, to name just a few of the specialties that are going to create huge opportunities for new employment in our state.

Marna Borgstrom, CEO of Yale New Haven Health, which includes the hospital, said, Theres great work being done here and our interest has been, who does this apply to and how can we make this available to patients? And with our partners at the medical school were committed to providing unparalleled value to people we serve, and part of value is giving people outcomes that are meaningful to them.

And so you start to think about areas like prenatal diagnoses, like certain newborn diseases, difficult cancers and the ability to take all of the drugs and the treatments and the information thats out there but actually create a specialized plan for each patient as each patients going to respond differently, she said.

Call Ed Stannard at 203-680-9382.

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Gene sequencing at Yale finding personalized root of disease; new center opens in West Haven - New Haven Register

Chemistry project that helps local fire department presented at national conference – New Bern Sun Journal

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By Deborah Kania, Craven Community College

Fifth-year Craven Early College (CEC) students Emily Chance and Sar Oo attended the 253rdnational meeting of the American Chemical Society held in April in San Francisco, Ca.

Chance and Ooand Craven Community College instructor Don Carpenetti presented, Evaluation and refinement of theprocedure used to prepare training samples for arson detection K-9s.

This chemistry honors program project started in 2015 by former Craven CC students SydneyGiammona and Nicole Miller.

The project has been a collaborative effort between the students, NewBern Fire Department Marshal Danny Miller, and Darby who is a female K-9 arson dog trained as anaccelerant detection canine.

According to Hill, the collaboration between the fire department and chemistry program hasachieved the fire departments goals of acquiring training fuel that is consistent, readily available andaffordable.

We appreciate the help for the training fuel, said Hill.

In fall 2016, Chance picked up where the previous students left off as part of her honors project inchemistry class.

Oo assisted Chance with the laboratory experiments and making of the training fuel.

The students spent extra time out of class to complete the project.

Chance and Oo said they enjoyed learning more about chemistry and its many educational andcareer opportunities at the conference.

They also had some time to tour San Francisco, includingdragging their chemistry instructor around a nine-story mall according to Oo.

Carpenetti also presented, Reciprocal peer tutoring in general chemistry: Benefits to informationretention and lowered student test anxiety, to his peers at the chemistry conference.

Chance and Oo are both graduating from CEC in May with honors and as members of the PhiTheta Kappa international honor society.

Chance will graduate with her high school diploma, and an associate degree in arts, generaleducation and science.

She will attend N.C. State in the fall to study chemistry and forensics.

Afterreceiving my bachelors degree, I would like to enlist in the military, said Chance.

Oo will graduate with her high school diploma, and an associate degree in arts and science.

Shewill attend Elizabeth City State in the fall to study pharmaceutical science.

After college, Oo said shewould like to be a researcher.

The week before the chemistry conference, Carpenetti was honored in Los Angeles as a 2017National Science Teachers Association (NTSA) award winner in the college level category.

Thechemistry project was one of the abstracts he submitted in his application for the annual award. Theseteachers and science education professionals have shown tremendous dedication and commitment totheir students and to science education, noted NSTA President Mary Gromko.

Carpenetti plans to continue to recruit future students to continue working on this project.

Carpenetti said there is more to learn. When you conduct one experiment, it usually creates three orfour more, he said.

Deborah Kania is the director of marketing, communications and development liaison at CravenCommunity College.

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Chemistry project that helps local fire department presented at national conference - New Bern Sun Journal

Chemistry controlled on tiniest scale can create hollow nanoparticles – Science News

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Blame oxidation for rusted bridges and browned avocados. But this fundamental process can be harnessed for good, too and now scientists have scored front-row seats that could show them how.

Researchers watched at near-atomic resolution as iron nanoparticles transformed into iron oxide not rust in this case, but related compounds. That closeup view could help scientists better control oxidation and design corrosion-resistant materials or new kinds of catalysts, the researchers report in the April 21 Science.

This is the first time the oxidation process has been observed in such detail, says Andreu Cabot, a physicist at the Catalonia Institute for Energy Research in Barcelona who wasnt part of the study.

When a metal oxidizes, its atoms mix and mingle with oxygen atoms to create a new material. That process is perhaps most famous for creating rust, which flakes and corrodes. But iron can oxidize in a variety of ways, some of which are useful.

For instance, chemist Yugang Sun and his colleagues at Temple University in Philadelphia are trying to create hollow iron oxide nanoparticles that could serve as catalysts to speed up chemical reactions or as vessels to deliver drugs or store energy in chemical form. But making these nanoshells from iron nanoparticles requires precise control over the oxidation process.

If oxygen atoms work their way into an iron nanoparticle faster than the iron atoms can diffuse out, that nanoparticle becomes a tight, solid ball, Sun says. If the iron diffuses out faster than the oxygen comes in, on the other hand, it becomes the hollow sphere that Suns lab wants.

Controlling that process is difficult because it has been unclear exactly how these shells form on an atomic level, Sun says. Scientists havent been able to watch it happen, because high-powered microscopy techniques can disrupt the reaction or show the action in only two dimensions.

Suns team tried a different approach to observe the reaction, by shooting X-rays at many identical iron nanoparticles suspended in a liquid. Each time the X-rays hit a different material moving from the liquid to the solid, for instance they scattered.

Story continues after graphic

Researchers measured the way X-rays bounced off oxidizing nanoparticles and then used computer models to reconstruct where atoms were moving over the course of the chemical reaction. As the nanoparticles oxidized, small holes developed and merged together to eventually form a hollow iron oxide shell

By tracking how the X-rays bounced off many small, uniform iron nanoparticles, the researchers were able to reconstruct where individual atoms were going as the particles oxidized into hollow shells over the course of several hours.

The researchers watched as the iron moved out of the center of the nanoparticle to react with the oxygen, initially forming many small holes inside the nanoparticle. Eventually, those empty spaces merged together to form one big void in the middle of the nanoparticle.

The impact of this paper is more than just the hollow [nanoparticles], says Yadong Yin, a chemist at the University of California, Riverside who wasnt involved in the research. The imaging technique itself will be a useful way to study how other types of nanoparticles form something scientists still dont understand well, he says. It can be used to gain insight into other types of oxidation, too.

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Chemistry controlled on tiniest scale can create hollow nanoparticles - Science News

SQI Diagnostics to Exhibit at the National Biotechnology Conference – Yahoo Finance

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TORONTO, May 1, 2017 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or the "Company") (TSX-V: SQD; OTCQX: SQIDF), a life sciences and diagnostics company that develops and commercializes proprietary technologies and products for advanced microarray diagnostics, will be exhibiting at the American Association of Pharmaceutical Scientists (AAPS) National Biotechnology Conference in San Diego, California.

"We are pleased to be a contributor to this very prestigious conference," said Andrew Morris, CEO of SQI Diagnostics. "This event brings together the world's leading experts and representatives from all sectors of pharma and biotechnology drug development and gives us the opportunity to share our novel multiplexing applications in drug development testing. Over the past year, we have made significant progress in our work with our pharma and biotech customers and believeour unique productswill prove to be beneficial to our customers who are large, global pharmaceutical companies.

The conference will run from May 1-3, 2017. Please stop by and visit us at booth 316.

About SQI Diagnostics

SQI Diagnostics is a life sciences and diagnostics company that develops and commercializes proprietary technologies and products for advanced microarray diagnostics. The Company's proprietary microarray tests and fully-automated systems are designed to simplify protein and antibody testing workflow, increase throughput, reduce costs and provide excellent data quality. For more information, please visit http://www.sqidiagnostics.com.

Contacts:

Sales and Marketing Contact: Russ Peloquin Vice President, Global Commercial Operations 913.484.9022 rpeloquin@sqidiagnostics.com

Investor Relations Contact: Andrew Morris Chief Executive Officer 416.674.9500 ext. 229 amorris@sqidiagnostics.com

Forward-looking Information

This news release contains certain forward-looking statements, including, without limitation, statements containing the words "will", "may", "expects", "intends", "anticipates" and other similar expressions which constitute "forward-looking information" within the meaning of applicable securities laws. Forward-looking statements reflect the Company's current expectation and assumptions, and are subject to a number of risks and uncertainties that could cause actual results to differ materially from those anticipated. The forward-looking statements in this news release include without limitation, statements with respect to the Private Placement and the use of proceeds of the Private Placement. These forward-looking statements involve risks and uncertainties including, but not limited to risks related to the failure to obtain necessary regulatory and stock exchange approvals, general economic and market segment conditions, and international risk and currency exchange risks, agreements and future agreements to sell our products, the success of our Diagnostic Tools and Services business and our intent to build near-term revenue streams from this business, the successful regulatory filing and receipt of regulatory approvals for our later stage quantitative diagnostic kits, the acceleration of our revenue ramp, general economic and market segment conditions, competitor activity, technology changes and regulatory approvals. Such statements reflect the current views of the Company with respect to future events and are subject to certain risks and uncertainties and other risks detailed from time-to-time in the Company's ongoing filings with the securities regulatory authorities, which filings can be found at http://www.sedar.com. Actual results, events, and performance may differ materially. Readers are cautioned not to place undue reliance on these forward-looking statements. The Company undertakes no obligation to publicly update or revise any forward-looking statements either as a result of new information, future events or otherwise, except as required by applicable laws.

This news release does not constitute an offer to sell or a solicitation of an offer to sell any of the securities in the United States. The securities have not been and will not be registered under the U.S. Securities Act or any state securities laws and may not be offered or sold within the United States or to U.S. persons unless registered under the U.S. Securities Act and applicable state securities laws or an exemption from such registration is available.

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Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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SQI Diagnostics to Exhibit at the National Biotechnology Conference - Yahoo Finance

Prana Biotechnology Limited (ADR) (NASDAQ:PRAN) Soars On Xenetic Biosciences Inc. (NASDAQ:XBIO) Distribution … – StockNewsUnion

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Prana Biotechnology Limited (ADR) (NASDAQ:PRAN) Soars On Xenetic Biosciences Inc. (NASDAQ:XBIO) Distribution ...
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Prana Biotechnology Limited (ADR) (NASDAQ:PRAN) Soars On Xenetic Biosciences Inc. (NASDAQ:XBIO) Distribution ... - StockNewsUnion

UNCW receives largest ever donation, gift will support pharmaceutical and chemistry programs – Port City Daily

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PortCityDaily.com is your source for free news and information in the Wilmington area.

WILMINGTON The University of North Carolina Wilmington received a multi-million dollar gift today.

Quality Chemical Laboratories pledged a $5 million gift, to be donated over the next five years. The donation is the largest corporate philanthropic gift in the Universitys history. Quality Chemical Laboratories founder, Dr. Yousry Sayed is a longtime UNCW faculty member in the chemistry department. His wife, Linda Sayed, is a graduate of the University.

UNCW Chancellor Jose Sartarelli said the announcement was some time in the making.

We have been working on this for about a year, Sartarelli said. I have become involved more recently. Aswani Volety, our Dean of the College of Arts and Sciences, was very involved. This was a confluence of good things and good timing.

The Sayeds donation to UNCW will support new programs aimed at advancing study in pharmaceutical and chemistry. According to the administration hopes the gift will help the University further develop recent advances in chemistry, biochemistry, biology and marine biology. Over the coming years, the gift will provide funding for establishing distinguished professorships and research, and may also help support scholarships, faculty research and travel grants.

Sartarelli said the programs will help the school meet the current needs of the state and the growing health care market.

The programs will be under the department of chemistry and biochemistry. Were starting with a Masters program, and we hope to develop a Ph.D. program as well. The goal, of course, is to help connect our students with the growing field of health sciences, with clinical research organizations and testing.

Quality Chemical Laboratories employs many UNCW graduates from the chemisty and biochemistry programs, according to Sartarelli. He hopes the Sayeds gift will help prepare future graduates for similar jobs across the state.

In a press release, Dr. Sayed said he and his wife were happy to be able to give back to their University.

It is an honor to be able to make this small contribution to this great university we love and appreciate, and to invest in the future of this important area of study and the students we serve, said Sayed. My wife and I have been a part of the Seahawk family and have grown together with UNCW for decades, and to know we are contributing to the universitys mission and outcomes in some small way is very rewarding for us.

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UNCW receives largest ever donation, gift will support pharmaceutical and chemistry programs - Port City Daily

Anatomy of a Stokes masterclass – ESPNcricinfo.com

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Rising Pune Supergiant v Gujarat Lions, IPL 2017, Pune May 1, 2017

Rising Pune Supergiant were 10 for 3 in their chase of 162, and then 42 for 4, but nothing, not even a prolonged bout of cramps, was going to stop Ben Stokes

Star turn

Ever since the last World T20 final, when he was hit for four sixes in the final over of the chase, Ben Stokes has been the subject of some ridicule, especially when sold for a record sum in the IPL auction. Two days before he goes back to his house of horrors, Eden Gardens, Ben Stokes produced one of the great Twenty20 innings. And he did so while hobbling with a cramp in his calf in the last three overs of the chase. Nothing can wipe off what happened in Kolkata last year, but Stokes has done enough in this IPL season to quell those doubts around him.

Coming into this match, Stokes had won two match awards but both for bowling. He had scored only 127 from seven innings before this, but in Pune, coming in to bat in the second over, at the fall of the third wicket. he scored 63% of his team's total. He had batted sooner in an innings only four times before that.

In his 126 a night before, a near-perfect T20 innings, David Warner batted with a 78% control percentage, which is phenomenal when you are attempting to hit a boundary every second ball. Stokes displayed 79% control. That control percentage was bound to be higher because he hit only one boundary every five balls as against Warner's one every three balls, but the fact Stokes couldn't afford to keep swinging made this innings special.

Stokes also struggled against legspinner Ankit Soni. He picked the wrong 'uns out of the back of the hand, but the sliders out of the front of the hand kept going past his outside edge. The 11 balls Soni bowled to Stokes, for seven runs, brought his control percentage down. So Stokes had to strike against others but in a calculated manner because four wickets fell within the first six overs, and because MS Dhoni faced 10 dots in his first 12 balls.

So Stokes struck against Ravindra Jadeja to break the shackles, and then kept finding the boundary every time the asking rate threatened to go out of hand.

The wow moment

Things can happen before you realise in T20 cricket. You are four down early, you are looking to arrest the slide, and two spinners can run through six overs in no time. When you look up at the board, you can be staring at an unachievable asking rate. The previous 19 balls had got Rising Pune just nine runs, with the asking rate shooting from 8.5 to 10. Then Stokes swung. Bang and bang, Ravindra Jadeja was hit over midwicket and long-on. The innings was back on track, and this was the last over Jadeja bowled because Gujarat Lions couldn't get rid of Stokes at all.

ESPNcricinfo Ltd

Stats that matter

What they said

"Stokesy is a quality player and he certainly earned his cash." Enough said, captain Steven Smith

"We lost quite a few early wickets... Me and MS [Dhoni] just tried to keep it ticking. We just tried to go big at the start of the over, and cool it off." Ben Stokes on how he approached the chase

Sidharth Monga is an assistant editor at ESPNcricinfo

ESPN Sports Media Ltd.

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Greys Anatomy star Jesse Williams is still focused on his family … – Rare.us

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Jesse Williams and Aryn Drake-Lee are keeping things civil at least for the kids.

According to TMZ, Williams and Drake-Lee are focused on learning to co-parent their kids and have been since before announcing their separation.

Williams has reportedly moved out of the family home but still maintains constant contact with his young son and daughter. He reportedly sees his children a few times a week, and Drake-Lee has been accommodating when it comes to his filming schedule at Greys Anatomy.

RELATED: Chip Gaines has responded to the $1 million lawsuit brought forward by his former friends

Sources close to Drake-Lee claim that Williams still has some of his belongings in the house they shared and has been coming and going as he pleases.

Williams is reportedly asking for joint custody of the 1-year-old and 3-year-old. Drake-Lee has not yet responded to the divorce filing.

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Greys Anatomy star Jesse Williams is still focused on his family ... - Rare.us