Chili peppers, one of the world's most beloved spices, is showing much promise in terms of reducing fat percentage when introduced to one's daily diet.

In a recent report from Science Daily, a new study suggests that chili peppers may just be the missing key to increased weight loss.  The new study shows that  a compound in chilies called capsaicin, which also makes a chili hot to the taste, is responsible for initiating specific changes in protein.

According to lead researcher Jong Won Yun, this could very well be the good news the world has been waiting for.  If chili peppers can be used on a particular scale for lowering body weight, then chilies can be utilized to combat obesity.

Chili vs. obesity

Obesity is one of the world’s leading causes of chronic, degenerative diseases like adult-onset diabetes, hypertension and other cardiovascular maladies.  Being overweight has also been linked to cancer in the prostate and even the development of asthma.

Yun’s study made laboratory rats confirm their initial hypothesis that capsaicin can help burn off the calories.  Two groups of test animals were both given diets in high in fat. The control group was given a capsaicin supplementation, while the other group of rat were not given the chili compound.

After the study, the control group had lost an average of 8 percent of body weight compared to the group that did not receive capsaicin.  It was also discovered that capsaicin can produce changes in up twenty types of protein found in fat.

While the study did not provide a conclusive explanation that capsaicin actually reduces body weight, it can be viewed as a pioneering study that explores the anti-obesity effects of the chili compound on the molecular level. The study was published in the Journal of Preteome Research.

Fight visceral fat!

There are two main types of fat that people have to deal with: regular fat, which is found above the muscle tissues and visceral fat, which lies underneath the muscles of the abdominal region.  So what is the big difference?  Visceral fat actually surrounds many vital organs, including the liver and intestines.  According to recent studies, visceral fat may also contribute to the development of adult-onset diabetes and other diseases.

In a study published in the medical journal Obesity, lead researcher  Dr. Gary Hunter states that just eighty minutes of exercise every week can help fight off the formation of deadly visceral fat.  Initially, the 97 respondents (composed of European-American & African-American individuals) were given a calorie-restricted diet plus a regular exercise regimen.

After the study, the respondents were asked to continue exercising at least eighty minutes a week.  A year later, the researchers measured the amount of visceral fat the respondents had and found out that the ones who continued exercising regardless of the exercise model did not regain harmful visceral fat. The study concluded that this type of exercise was effective in reducing visceral in both the European-American respondents and African-American respondents.

Vinegar vs. fat

Vinegar, a natural byproduct of bacterial action, fruit/vegetable and water, is now being studied for its potential benefit as a fat fighter.  According to Japanese researcher Tomoo Kondo, vinegar showed great promise as a fat fighter when an animal test showed that acetic acid can reduce up to ten percent body fat in test animals.

How does it work?  Well, the established belief was that acetic acid activates a particular gene in the body responsible for breaking down fat.  When the gene is activated, the body starts producing proteins that help break down the stubborn stores of fat.  When this happens, accumulation of fat is greatly reduced.

Low carbs diet for lower blood pressure

For many years now, proponents of weight loss diets and regular practitioners of medicine have associated too much carbohydrates in one’s diet with higher risk of developing high blood pressure and uncontrollable weight gain.  According to Dr. William Yancy, the lead author of the study, a low-carbohydrate diet might be a better choice than investing in weight loss medication like orlistat.

The study indicated that while weight loss medication like orlistat can reduce weight, it did not produce identical beneficial effects on the respondents’ blood pressure.  This was not the same for the low-carbohydrate group.  Nearly fifty percent of the respondents in the low carbohydrate group were able to reduce their blood pressure.  Some of them had such an improvement that they were able to discontinue medication.  Only twenty-one percent in the weight loss medication group experienced a reduction of their blood pressure.

Sources:
aolhealth.com
sciencedaily.com
sciencedaily.com
sciencedaily.com
sciencedaily.com

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Smoking cessation plus exercise can improve the male sexual function and also improve the urinary health of both males and females.

In a recently concluded study presented in the annual conference of the American Urological Association, researchers pointed to a vital link between smoking, exercise and urinary health.

The study involved two thousand individuals (males and females). The respondents were interviewed about their smoking habits and were also given questions regarding their urinary health.  It was found that individuals who smoked were three times more likely to urinate frequently.

Also, these individuals are also 2.7 times more prone to experience sudden urges to go to the bathroom to urinate.

In a related study performed by US researchers from South Carolina, it was found that men who exercised more had experienced improved sexual function.  The two studies, if taken together, point to an age-old medical adage: folks have to stop the smoking habit and begin a healthier habit – exercise!

More reasons to love exercise

Here are even more reasons to love exercise:

1. Exercise reduces the risk of mortality from chornic, degenerative health conditions.

2. Exercise reduces the chance of developing of type 2 or insulin-dependent diabetes.

3. Exercise can help control the blood pressure, even the blood pressure of people already have cardiovascular problems.

4. Exercise can help reduce the probability of developing one of the top killers worldwide: colon cancer.

5. Exercise helps improve your mood and also helps people ease out of anxiety and depression.

6. Exercise improves balance, coordination and also strengthens the bones and muscles, therey reducing the risk of fractures from falls.

7. Exercise is also an excellent means of losing weight.

8. Exercise make the body and mind more fit. If you are physically and mentally fit, you would be able to perform better at work or in school.

9. Exercise reduces the risk of stroke.

Exercise may also reduce the risk of breast cancer and loss of bone mass (osteoporosis) – two common problems of women over the age of 45.

Sources:
aolhealth.com
nutristrategy.com
www2.gsu.edu
medicinenet.com

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Higher doses of cranberry can help treat UTI or urinary tract infections by helping remove the bacteria from the surface of the urinary tract tissue.

According to a study performed by researchers from Rutgers University,  72 mg of cranberry (Vaccinum macrocarpon) can help ward off and even treat urinary tract infections or UTIs.

The study directly supports an early health claim from France that states that at least 36 grams of fresh cranberries is effective against UTI because it prevented some of the Escherichia coli (E. Coli) bacteria from sticking to the urinary tract (in males and females).

According to lead researcher Amy Howell, there is still much more to explore in terms of determining the most effective dose to fight off urinary tract infections.  The study was performed in different countries, including Japan, Hungary and even in Spain. Howell reports that they are also trying to determine the link between the adhesion of the bacteria responsible for UTI and the origins of the respondents.

What the study does show presently is that as the cranberry dose increases, the more effective it becomes in fighting off the adhesion of the bacteria.  The study noted 50% less adhesion at eighteen milligrams and 100% less adhesion at seventy-two grams of cranberries.

Cranberry health benefits

In addition to its ability to fight off infections of the urinary tract, cranberry can also boost your health in other ways:

1. Drinking fresh cranberry juice or drinking cranberry supplements can help reduce the occurrence of cystitis in women.  Drink lots of water, too, because water has the ability of flushing out bacteria naturally.

2. Cranberries are packed with vital nutrients, including protein, carbohydrates, fiber, fruit sugars, calcium, iron, magnesium, phosphorous, potassium, zinc, ascorbic acid, riboflavin, niacin, pantothenic acid, vitamin B6, vitamin B12, folate, vitamin A, E, K and lutein. It’s nature’s power-packed fruit with all the nutrients you would need to stay healthy.

3. According to a study performed in Cornell University, cranberries have the ability to arrest the growth and maturation of breast cancer cells.

4. Cranberries can help reduce LDL or bad cholesterol.

5. Due to the fruit’s anti-bacterial activity, cranberry may also help prevent tooth decay.

6. Cranberry also strengthens the respiratory system.

7. The fruit may also help ward off stomach ulcers caused by Helicobacter pylorii.

Sources:
nutraingredients.com
nutrition.about.com
nutrition.about.com
breastcancer.about.com
nutrasanus.com

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Maria Konovalenko on the study of the often large life span differences between similar species - or rather the lack of such research work in comparison to other fields of life science: "Here's this quite simple idea: to take two species similar in size and basic biology, but having a substantial difference in longevity, and figure out what's the reason for this difference. What are the distinctions in the mechanisms of aging and stress resistance? It's desirable to carry out this work in various species. However, not a lot of people are excited about this simple idea. Even the genome of the famous naked mole rat has not been sequenced yet, although many people believe it's got 'negligible' senescence. For now all that we have is negligible funding of evolutionary-comparative biology of aging. Moreover, previously obtained results are put into cold storage. ... And here comes the main question in biogerontology. Why is the research into the fundamental mechanisms of aging so scarcely funded?" Aging and longevity research in general receives very little funding and attention in comparison to its importance to the future of human health. This state of affairs is slowly changing, but not fast enough for my liking.

View the Article Under Discussion: http://maria-konovalenko.typepad.com/blog/2010/06/the-main-question-in-biogerontology.html

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Via Newswise: "Why all the attention on TOR? TOR (target of rapamycin) is a key nutrient-sensing catalytic enzyme that evolution has conserved among every plant and animal species that has cells containing a nucleus. TOR mediates the connection between nutrients in the environment to the growth and metabolism of the organism. Studies in flies, worms, yeast and mice support the notion that the TOR signaling network also plays a pivotal role in regulating the aging process. When TOR signaling is reduced, either through genetic manipulation or via the use of drugs, the organism presumes there are reduced nutrients in its environment and goes into a 'survival' mode similar to that seen in dietary restriction, which has been shown to extend lifespan and slow the onset of certain age-related diseases. ... it remains to be seen which downstream effectors of TOR are key drivers of longevity and which ones elicit only minor effects. In addition to simply extending lifespan, research on the protective effects of TOR is likely to identify which age-related diseases can be slowed by inhibition of the TOR pathway."

View the Article Under Discussion: http://www.newswise.com/articles/tor-a-key-mediator-of-the-effects-of-dietary-restriction-and-its-impact-on-aging

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

From Depressed Metabolism, a look at the folk who are trying to ensure that cryonics patients can preserve their resources as well as the fine structure of their brains: "On the weekend of April 23-25 I attended a meeting of the cryonics Asset Preservation Group held [near] Gloucester, Massachusetts. I will try to give a few brief summaries without going into detail about every presentation. ... A central problem for cryonicists wanting revival trusts is that Cryopreserved Persons (CPs) are legally dead and are not ascertainable beneficiaries under trust law. My solution to this problem has been to have cryonics organizations (rather than the legal system) recognize the reanimated CP as the beneficiary. But finding the right cryonics organization to do this is not always easy. ... the best presentation at this meeting of the Asset Preservation Group was the one on 'Personal Revival Trusts' by Igor Levenberg. I have been working with the thorny problems associated with cryonics reanimation trusts for years and I have never seen such careful and persuasive legal analyses."

View the Article Under Discussion: http://www.depressedmetabolism.com/2010/06/02/fourth-asset-preservation-group-meeting/

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

From Singularity Hub: "In order to work in the human body, an artificial cornea has to meet some rather stringent requirements. First, it has to bond to the human eye around its edge, but stay unclouded by cells in its center. To that end, [researchers] took a widely used opthalmological polymer (found often in intraocular lenses) and adapted it with other special polymers around the edges. Combined with the application of a growth factor protein, the modified edge promoted cell growth around the periphery of the implant and secured it in place using the body's own cells. The center of the artificial cornea, however, does not promote cell growth and remains clear so that it can be seen through. The artificial cornea also has to move freely with the eyelid and balance moisture on its faces. The polymer [researchers] chose is hydrophobic, allowing tears to lubricate the surface and provide the correct moisture on both of its sides. ... The artificial cornea has passed clinical trials and is ready to see expanded use in patients this year."

View the Article Under Discussion: http://singularityhub.com/2010/06/02/germanys-artificial-cornea-getting-ready-to-restore-sight-to-thousands/

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Researchers are turning up new longevity genes at a fair rate these days, and this latest discovery is illustrative of the methods used - start with what you know, and compare and contrast: "A major challenge in translating the positive effects of dietary restriction (DR) for the improvement of human health is the development of therapeutic mimics. One approach to finding DR mimics is based upon identification of the proximal effectors of DR life span extension. Whole genome profiling of DR in Drosophila shows a large number of changes in gene expression, making it difficult to establish which changes are involved in life span determination as opposed to other unrelated physiological changes. We used comparative whole genome expression profiling to discover genes whose change in expression is shared between DR and two molecular genetic life span extending interventions related to DR, increased dSir2 and decreased Dmp53 activity. We find twenty-one genes shared among the three related life span extending interventions. One of these genes, takeout, thought to be involved in circadian rhythms, feeding behavior and juvenile hormone binding is also increased in four other life span extending conditions: Rpd3, Indy, chico and methuselah. We demonstrate takeout is involved in longevity determination by specifically increasing adult takeout expression and extending life span. These studies demonstrate the power of comparative whole genome transcriptional profiling for identifying specific downstream elements of the DR life span extending pathway."

View the Article Under Discussion: http://www.ncbi.nlm.nih.gov/pubmed/20519778

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Researchers are turning up new longevity genes at a fair rate these days, and this latest discovery is illustrative of the methods used - start with what you know, and compare and contrast: "A major challenge in translating the positive effects of dietary restriction (DR) for the improvement of human health is the development of therapeutic mimics. One approach to finding DR mimics is based upon identification of the proximal effectors of DR life span extension. Whole genome profiling of DR in Drosophila shows a large number of changes in gene expression, making it difficult to establish which changes are involved in life span determination as opposed to other unrelated physiological changes. We used comparative whole genome expression profiling to discover genes whose change in expression is shared between DR and two molecular genetic life span extending interventions related to DR, increased dSir2 and decreased Dmp53 activity. We find twenty-one genes shared among the three related life span extending interventions. One of these genes, takeout, thought to be involved in circadian rhythms, feeding behavior and juvenile hormone binding is also increased in four other life span extending conditions: Rpd3, Indy, chico and methuselah. We demonstrate takeout is involved in longevity determination by specifically increasing adult takeout expression and extending life span. These studies demonstrate the power of comparative whole genome transcriptional profiling for identifying specific downstream elements of the DR life span extending pathway."

View the Article Under Discussion: http://www.ncbi.nlm.nih.gov/pubmed/20519778

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Accelerated aging conditions may result from individual aspects of "normal" aging run wild and out of control. This means we can potentially learn more about those mechanisms. For example: "a gene shown to play a role in the aging process appears to play a role in the regulation of the differentiation of embryonic stem cells. ... researchers identified a protein interaction that controls the silencing of Oct4, a key transcription factor that is critical to ensuring that embryonic stem cells remain pluripotent. The protein, WRNp, is the product of a gene associated with Werner syndrome, an autosomal recessive disorder hallmarked by premature aging. ... We showed that the depletion of WRNp blocked the recruitment of Dnmt3b to the Oct4 promoter, and resulted in reduced methylation. The reduced DNA methylation was associated with continued Oct4 expression, which resulted in attenuated differentiation. ... These results reveal a novel function of WRNp, and demonstrate that WRNp controls a key step in pluripotent stem cell differentiation. Our data support the emerging hypothesis that attenuated stem cell differentiation is involved in aging. This lack of differentiated cells may contribute to failure to maintain organ or tissue function in the later stages of life."

View the Article Under Discussion: http://sify.com/news/aging-related-gene-plays-role-in-stem-cell-differentiation-news-international-kgfnOiabcdj.html

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

While we're on the subject of the importance of the brain to engineered longevity, here is news of an infrastructural advance from EurekAlert!: "The Allen Institute for Brain Science announced today that it has launched the Allen Human Brain Atlas, a publicly available online atlas charting genes at work throughout the human brain. The data provided in this initial data release represent the most extensive and detailed body of information about gene activity in the human brain to date, documenting which genes are expressed, or 'turned on' where. In the coming years, the Atlas will be expanded with more data and more sophisticated search, analysis and visualization tools to create a comprehensive resource useful to an increasingly wide range of scientists and research programs worldwide. The Allen Human Brain Atlas, available at http://www.brain-map.org, is a unique multi-modal atlas of the human brain that integrates anatomic and genomic information to create a searchable, three-dimensional map of gene activity in the brain. Data modalities in this resource include magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) and histology - providing information about gross neuroanatomy, pathways of neural connections, and microscopic anatomy, respectively - as well as gene expression data derived from multiple approaches."

View the Article Under Discussion: http://www.eurekalert.org/pub_releases/2010-05/aifb-aif052410.php

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Here is a presentation given by researcher Anders Sandberg for Google's Tech Talk series: "The idea of creating a faithful, one-to-one computer copy of a human brain has been a popular philosophical thought experiment and science fiction plot for decades. While computational neuroscience and systems biology are currently very far away from this goal, the trends towards large-scale simulation, industrialized neuroinformatics, new forms of microscopy and powerful computing clusters point in this direction and are enabling new forms of simulations of unprecendented scope. In this talk I will discuss current estimates of how close we are to achieving emulated brains, technological requirements, research challenges and some of the possible consequences." A little while back the Future of Humanity Institute published a roadmap to whole brain emulation. This topic is of interest to supporters of engineered longevity as a part of the very long term goal of incrementally replacing the vulnerable biology of the brain with something more robust and damage-resistant. Such as, for example, clusters of diamondoid nanomachines designed to emulate the functions of neurons.

View the Article Under Discussion: http://www.aleph.se/andart/archives/2010/06/whole_brain_emulation_the_logical_endpoint_of_neuroinformatics.html

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

The New Scientist on calorie restriction: "Dreams of eternal youth feature in many cultures throughout history, but it was only in the 20th century that research into longevity really began. Much about ageing is still mysterious - we don't even know the underlying reasons why we journey into old age. There are many lines of enquiry into how to live longer, though, with one of the most intriguing being calorie restriction: in effect, going on a lifelong diet. Calorie restriction dramatically extends not only the lifespan of laboratory animals, but also their 'healthspan' - how long they live free of disease. On the assumption that it has the same effect in people, some individuals have already adopted a restricted diet. The latest evidence suggests that while calorie restriction is indeed beneficial for humans, when it comes to lifespan extension, it may not be the whole story. The good news is that we might be able to delay ageing without cutting our food intake. ... There's a definite possibility that if you balance the diet correctly, a longer lifespan can be achieved without full food restriction. ... It is unclear why eating less should make animals live longer. While a restricted diet triggers numerous changes at the molecular and genetic levels, only some of these are common across all the species tested. However, there does seem to be a general principle that a dearth of nutrients causes organisms to divert resources away from growth and reproduction and towards basic survival functions. From an evolutionary perspective, these adaptations could help an organism survive famine."

View the Article Under Discussion: http://www.newscientist.com/article/mg20627621.100-eat-less-live-longer.html?full=true

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

From Depressed Metabolism: "Some contemporary atheists and secular humanists do not stop at debunking the idea of God but seem to think that making a persuasive case against religion requires them to refute all of its associated ideas as well; including the desire for immortality. Paula Kirby is not the first secular person praising our limited lifespan and glorifying death: 'For atheists it is the very transience of life that helps to give it its meaning: for it prompts us to live it to the full' ... Kirby does not just repeat the hollow non-empirical cliche that life can only have meaning in the face of death but she also pretends to speak on behalf of all atheists. As can be expected, she cannot imagine an extremely long lifespan to be anything else than unspeakable boredom. When she writes that 'Susan Ertz got it spot on with her witty remark that millions yearn for immortality who don't know what to do with themselves on a rainy Sunday afternoon' one cannot help thinking that she is conveying more information about herself and Susan Ertz than about humans in general. ... It is remarkable to what extent the notion of death as not only biological but ontological necessity has permeated Western philosophy - remarkable because the overcoming and mastery of mere natural necessity has otherwise been regarded as the distinction of human existence and endeavor."

View the Article Under Discussion: http://www.depressedmetabolism.com/2010/05/25/humanist-death-apologetics/

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Vitamin D has been linked to many health conditions before. A recent study links insufficient levels of the vitamin with the disabling condition depression

In a recent study performed by researchers from the National Institute of Aging in the United States, insufficient levels of vitamin D may be the reason why many individuals over the age of 65 are experiencing symptoms of depression.

Senior individuals often have low levels of the important vitamin because they tend to stay indoors more often, as opposed to younger, more sprightly individuals with more active lifestyles. The study was published in a medical journal on endocrinology this year.

According to Luigi Ferrucci, the lead researcher, the emerging link between vitamin D deficiency and the occurrence of depression must be further investigated.  The study involved a follow-up testing of nearly one thousand male and female respondents within a six-year period.

The researchers used a specialized scale that measured the symptoms of depression called CES-D.  The researchers discovered that those with lower levels of vitamin D in their blood tended to have poorer score in the CES-D test.  Those with higher vitamin D percentages in their blood scored better in the same test.

Alarming, global trend

Depression is fast becoming one of the leading causes of disability around the world, not just in the United States.  It is estimated that today, there are 120 million people afflicted with the condition.  Ferrucci’s study is not the first to point at the possible link between the vitamin and depression.

In an earlier study carried out two years ago, Dutch researchers reported that insufficient levels of the vitamin in the body resulted in a higher percentage of the parathyroid hormone.

This hormone, which is used by the body to regulate calcium loss, has been directly linked to a higher incidence of depression in some one thousand two hundred respondents in yet another independent study.  This is the reason why a causal pathway must be mapped out to determine just how this vitamin affects the human brain.

In a fourth related study, researchers McCann and Arnes noted that vitamin D is important for the proper functioning and health of the human brain.  The widespread presence of vitamin D receptors throughout the human brain is evidence of the vital role of the nutrient in brain health.

According to yet another scientific review, vitamin D has been associated with affecting proteins in the human brain that are responsible for governing the learning process and remembering.  If an imbalance occurs in these areas, you can just imagine a chain reaction occurring throughout the brain.

Benefits of vitamin D

There are several ways that you can get vitamin D: natural exposure to sunlight, food (like dairy products, e.g. yogurt, milk, etc.) and through vitamin supplementation.  The body only needs about 10 – 15 minutes of exposure to natural sunlight to produce vitamin D on its own.

If this is not possible, people with low levels of vitamin D should explore vitamin supplementation; this applies most especially to senior individuals who may not be eating well or are unable to engage in a more active lifestyle.  Instead of using sunscreen when going out to get your healthy dose of sunshine, you can protect your skin naturally by taking natural antioxidants like fresh wheatgrass juice and citrus fruits.

The usual recommended dose for adults is between 400 to 800 IU (international units) of vitamin D everyday. Pregnant women should be given a higher dose (800 IU) to ensure optimum bone health and proper development of the fetus.

And there are more reasons to love vitamin D! Here are some of the most important benefits:

1. It is needed for proper absorption and utilization of calcium and phosphorous.  It is needed for the proper maintenance and repair of the bones and skin.

2. It strengthens and helps maintain the immune function of the body. Conditions like flu and the common cold can be warded off more efficiently if the immune system is strengthened by vitamin D.

3. It is an important nutrient that prevents the occurrence of MS (multiple sclerosis).  According to researchers from the Oregon Health & Science University, MS is less frequent in tropical countries because there is more available sunshine in these places than in temperate regions.

4. Vitamin D has also been linked to the maintenance of normal body weight (according to research from the Medical College of Georgia).

5. Vitamin D is important for brain health in the later years (60 – 79 years of age).

6. In a recent study from the Harvard Medical School, vitamin D can also reduce asthma attacks in asthmatic individuals.

7. We are exposed continually to low levels of radiation.  The good news is vitamin D can also help protect us from such exposures.

According to US cancer researchers, people with adequate levels of vitamin D have a lower risk for many types of cancer than people with low or inadequate levels of the vitamin.

Sources:
nutraingredients.com
healthvitaminsguide.com
medicalnewstoday.com

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