Author Archives: Fredricko

Lifestyle study highlights key differences in relapsing and progressive onset multiple sclerosis

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ScienceDaily (Mar. 19, 2012) Patients with relapsing onset Multiple Sclerosis (MS) who consumed alcohol, wine, coffee and fish on a regular basis took four to seven years longer to reach the point where they needed a walking aid than people who never consumed them. However the study, published in the April issue of the European Journal of Neurology, did not observe the same patterns in patients with progressive onset MS.

The authors say that the findings suggest that different mechanisms might be involved in how disability progresses in relapsing and progressive onset MS.

Researchers asked patients registered with the Flemish MS Society to take part in a survey, which included questions on themselves, their MS and their current consumption of alcohol, wine, coffee, tea, fish and cigarettes.

The 1,372 patients who agreed to take part were also asked to indicate whether they had reached stage six on the zero to ten stage Expanded Disability Status Scale (EDSS) and, if so, when this had happened.

"MS is a chronic, often disabling disease that attacks the central nervous system" explains lead author Dr Marie D'hooghe from the National MS Center at Melsbroek, Belgium. "The clinical symptoms, progression of disability and severity of MS are unpredictable and vary from one person to another.

"Two major MS onset types can be distinguished. Progressive onset MS is characterised by a gradual worsening of neurological function from the beginning, whereas patients with relapsing onset MS patients experience clearly defined attacks of worsening neurologic function with partial or full remission.

"EDSS 6 is an important milestone in the development of MS as it is the point at which patients need support to walk a reasonable distance."

The patients who took part were aged between 17 and 89 years-of-age:

The researchers analysed how long it had taken people to reach EDSS 6 and compared those who reported moderate consumption of fish, alcoholic and non-alcoholic drinks and cigarettes with those who reported occasional or no consumption. This showed that:

The time differences quoted above did not take into account gender, age at onset and treatment, which are known to affect disability progression in MS. But even after adjusting for these factors, the hazard risk analysis for time to sustained EDSS 6 (where 1.0 was the reference number for zero consumption) showed that:

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Lifestyle study highlights key differences in relapsing and progressive onset multiple sclerosis

HOUSE CALL: Raising hope: The future of Multiple Sclerosis

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By Dr. Mark Tullman stltoday.com | Posted: Wednesday, March 21, 2012 5:45 am | (Loading) comments.

Multiple Sclerosis (MS) is an immune-mediated disease that affects the brain, nerves that connect the eyes to the brain, and spinal cord. Approximately 400,000 people in the U.S. have MS, which typically begins between the ages of 20 and 40 and is the leading cause of non-traumatic disability in young adults.

2011 was a remarkable year in MS. Here's a glimpse at some of the latest discoveries:

Twenty-nine new genes that influence the risk of developing MS were identified.

New criteria were established that allow for an earlier MS diagnosis.

Researchers found that higher vitamin D levels in people with MS are associated with fewer new brain MRI lesions. * Another study concluded vitamin D supplementation in combination with interferon (an MS medication) may be more effective than interferon alone. Studies are ongoing to conclusively determine if vitamin D supplementation is beneficial in MS.

Research suggests individuals with MS who smoke may be more likely to develop disability. People with MS who smoke should definitely try to stop.

In 2008, a vascular surgeon, Dr. Paolo Zamboni, coined the phrase chronic cerebrospinal venous insufficiency (CCSVI) to describe a state of impaired drainage of blood from the brain and spinal cord due to narrow veins in people with MS.

He has speculated CCSVI might contribute to the cause of MS and surgery to improve blood flow might be a treatment for MS. Numerous studies in the past year have yielded conflicting results regarding the frequency of CCSVI in MS.

Some revealed no evidence of CCSVI while others reported CCSVI in healthy individuals. Research is ongoing to determine if CCSVI is related to MS. If an association is confirmed, a study to determine if surgical treatment of blocked veins is safe and effective should begin later this year.

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HOUSE CALL: Raising hope: The future of Multiple Sclerosis

Arcadia sex offender with dementia is reported missing

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Arcadia police are searching for a convicted sex offender with dementia who went missing last week.

James Randall McCain, 58, was last seen at his home on Huntington Drive in Arcadia on March 12, police said. He was reported missing the next day.

After visiting the residence this weekend, police do not believe he has returned there since his disappearance.

McCain has been registered in Arcadia as a sex offender for a long time, said Sgt. Dan Crowther, and has never been a problem. Police said he usually gets around by foot and is not known to drive. He has a conviction for lewd and lascivious acts on a child under 14, KTLA-TV reported.

Police are asking anyone with more information about his whereabouts to contact the Arcadia Police Department at (626) 574-5156.

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--Anna Gorman

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Arcadia sex offender with dementia is reported missing

Health Matters: Differences between Alzheimer's and dementia

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FORT MYERS, FL -

Hank Graefen's mother-in-law suffered from dementia. When he and his wife became caretakers in her final years, they studied up on the condition.

"The more you can learn the better you're going to be and you better understand the disease."

Often used interchangeably, both dementia and Alzheimer's are forms of mental degradation. In many ways they seem the same but are actually two different medical terms.

"I tell people that its sort of like dementia is the team and Alzheimer's is one of the players," says Dr. Michael Raab, a geriatrician with Lee Memorial Health System.

Dementia covers a number of disorders; Alzheimer's is most common.

"Depending on who you believe, between 60% and 80% are caused by Alzheimer's disease," says Dr. Raab.

Alzheimer's has physical characteristics in the brain, which most other forms of dementia don't have.

"When you look at the brain, there are tangles and plaques. The Lewy Body dementias, the vascular dementias, the front dementias, none of them really have any plaques or tangles," says Dr. Raab.

What's more, Alzheimer's involves a gradual progression that can begin in middle age. General dementia is usually found in advanced years, Hank's mother-in-law was in her 90s.

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Health Matters: Differences between Alzheimer's and dementia

Health Matters: Differences between Alzheimer’s and dementia

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FORT MYERS, FL -

Hank Graefen's mother-in-law suffered from dementia. When he and his wife became caretakers in her final years, they studied up on the condition.

"The more you can learn the better you're going to be and you better understand the disease."

Often used interchangeably, both dementia and Alzheimer's are forms of mental degradation. In many ways they seem the same but are actually two different medical terms.

"I tell people that its sort of like dementia is the team and Alzheimer's is one of the players," says Dr. Michael Raab, a geriatrician with Lee Memorial Health System.

Dementia covers a number of disorders; Alzheimer's is most common.

"Depending on who you believe, between 60% and 80% are caused by Alzheimer's disease," says Dr. Raab.

Alzheimer's has physical characteristics in the brain, which most other forms of dementia don't have.

"When you look at the brain, there are tangles and plaques. The Lewy Body dementias, the vascular dementias, the front dementias, none of them really have any plaques or tangles," says Dr. Raab.

What's more, Alzheimer's involves a gradual progression that can begin in middle age. General dementia is usually found in advanced years, Hank's mother-in-law was in her 90s.

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Health Matters: Differences between Alzheimer's and dementia

Thomson Reuters Identifies United Kingdom as a Leader in Dementia Research

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Amid high-caliber research output and citation impact, analysis reveals region has unfilled potential to accelerate dementia cure

Philadelphia, PA, London, UK, March 20, 2012 - The Intellectual Property & Science business of Thomson Reuters today announced findings that the quality of dementia research in the United Kingdom (UK) is second in the world only to the United States, despite the low number of scientists working in this field, and that finding a cure can be accelerated by increasing the number of dementia researchers and investment, according to work done using the Thomson Reuters Web of Knowledge(TM). The findings are featured in an Alzheimer`s UK Research Report "Defeating Dementia."

The results from the analysis reveal the UK published more research on dementia than any other country except the United States and ranks second in the world after Sweden in citation impact, which is the number of times UK research is referenced in dementia studies around the globe. Despite its high performance and influence, dementia research capacity in the UK is low when compared to cancer, stroke and heart disease. For every dementia research scientist there are six who work on cancer.

"Research output and citation impact in scientific literature is an ideal way to measure the quality and capacity of dementia research," said Karen Gurney, manager of bibliometric reporting at Thomson Reuters and analyst of this report. "This project illuminated an interesting dementia-research landscape in the UK, where this region is clearly playing an influential role despite its size."

The research study was commissioned by the UK`s leading dementia research charity, Alzheimer`s Research UK, in an effort to raise awareness and increase investment for the underfunded field. The data measuring the quality and size of dementia research in the UK was compiled by Thomson Reuters. Issued by Alzheimer`s UK, the report, Defeating Dementia, also outlines 14 recommendations to the UK government based on feedback from scientists working in the field.

"The data provided by Thomson Reuters have been extremely valuable in allowing Alzheimer`s Research UK to uncover the facts about dementia research output and quality in the UK," said Simon Ridley, head of research at Alzheimer`s Research UK. "We wanted to dig deep into the issue of UK research capacity in this field. The work carried out by Thomson Reuters enabled us to do this and make a strong case for more investment in dementia research."

Rebecca Wood, chief executive, Alzheimer`s Research UK, concurs. "Alzheimer`s Research UK relies on robust data to support its expertise. The data provided by Thomson Reuters allowed us to present an in-depth picture of UK dementia research in a global context over the last fifty years. It has been very well-received by a range of stakeholders, including government and other research funders."

To view the Alzheimer`s Research UK report, Defeating Dementia, visit: http://www.alzheimersresearchuk.org.

Thomson Reuters Thomson Reuters is the world`s leading source of intelligent information for businesses and professionals. We combine industry expertise with innovative technology to deliver critical information to leading decision makers in the financial, legal, tax and accounting, healthcare and science, and media markets, powered by the world`s most trusted news organization.With headquarters in New York and major operations in London and Eagan, Minnesota, Thomson Reuters employs more than 55,000 people and operates in over 100 countries. Thomson Reuters shares are listed on the Toronto and New York Stock Exchanges. For more information, go to http://www.thomsonreuters.com.

Alzheimer`s Research UK Alzheimer`s Research UK is the UK`s leading dementia research charity. As research experts, we fund world-class, pioneering scientists at leading universities to find preventions, treatments and a cure for dementia. Our findings improve the lives of everyone affected by dementia now and in the future. We forge partnerships with Government and other key organizations to make dementia research a national priority.

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Thomson Reuters Identifies United Kingdom as a Leader in Dementia Research

Lakeside Center for Autism uses technology as treatment tool

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March 20, 2012

By Warren Kagarise

Dan Stachelski, CEO, director and a speech-language pathologist at Lakeside Center for Autism, stands at a mosaic of jigsaw puzzle pieces made by some of the youngsters in art class who attend the school. By Greg Farrar

The hustle and bustle at Lakeside Center for Autism is intentional.

Tucked in rooms outfitted in technology both tried-and-true and cutting-edge, children and therapists spend hours each day to overcome the obstacles put in place by autism. The commotion and laughter emanating from behind the closed doors come as signs of success.

Lakeside Center for Autism uses the popular Microsoft Kinect system and other tools to treat the complicated neural development disorder.

Its all about participation, company CEO, president and founder Dan Stachelski said. Technology can do that.

Stachelski, a Snoqualmie resident, founded and developed Lakeside Center for Autism after forming a sprawling in-home speech therapy practice across the Eastside. Now, Lakeside Center for Autism serves 100 families and conducts 1,700 appointments each month.

The company has earned local and national attention for using Kinect to treat autism.

Issaquah Chamber of Commerce leaders spotlighted Lakeside Center for Autism as a business innovator in the Innovation in Issaquah contest late last month.

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Lakeside Center for Autism uses technology as treatment tool

Families of kids with autism earn less

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Rachael Rettner MyHealthNewsDaily

Adriana Lara, a mother in Hutto, Texas, is not able to work because her 5-year old son Joshua has autism. Lara must stay home to give Joshua the care he needs, and to drive him to his therapy sessions five days a week.

"It's just impossible for me to be able to hold a job and do all these things with Josh," Lara, 31, said. The family depends on the salary of Lara's husband, a psychologist at a Veteran's Affairs hospital.

Joshua's therapies, including speech, music and occupational therapy, cost about $5,000 a month. Eighty-five percent of the cost is currently covered by a government grant, but the grant will run out this summer, and the family's insurance policy won't cover Joshua's therapies, Lara said.

"We dont know how we're going to afford it," Lara said. While public schools offer autism therapies, Joshua's school does not offer the type of intensive therapies he needs, Lara said. For instance, the therapies provided by Joshua's school are not one-on-one, Lara said.

A new study highlights the unique financial burden faced by families of children with autism, like Lara's. The burden is particularly significant for mothers, the study finds.

On average, mothers of autistic children earn $14,755 less per year than mothers of healthy children, and $7,189 less per year than mothers of children with other health conditions (such as asthma and ADHD) that limit their ability to engage in childhood activities, according to the study.

Despite the fact that they tend to have completed more years of education, mothers of autistic children are 6 percent less likely to be employed, and they work on average 7 hours less weekly than mothers of healthy children, the researchers say.

"We don't think that autism creates more of a strain on the family per se than other chronic conditions of childhood," said study researcher David Mandell, associate professor of psychiatry and pediatrics at the University of Pennsylvania School of Medicine. "I think the reason these mothers are leaving the workforce is because the service system for children with autism is so fragmented," Mandell said.

Health care and workplace policies need to recognize the full impact of autism, and alleviate costs for the families with greatest needs, the researchers concluded, writing in the March 19 issue of the journal Pediatrics.

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Families of kids with autism earn less

Parents of Kids with Autism Earn Less

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Adriana Lara, a mother in Hutto, Texas, is not able to work because her 5-year old son Joshua has autism. Lara must stay home to give Joshua the care he needs, and to drive him to his therapy sessions five days a week.

"It's just impossible for me to be able to hold a job and do all these things with Josh," Lara, 31, said. The family depends on the salary of Lara's husband, a psychologist at a Veteran's Affairs hospital.

Joshua's therapies, including speech, music and occupational therapy, cost about $5,000 a month. Eighty-five percent of the cost is currently covered by a government grant, but the grant will run out this summer, and the family's insurance policy won't cover Joshua's therapies, Lara said.

"We dont know how we're going to afford it," Lara said. While public schools offer autism therapies, Joshua's school does not offer the type of intensive therapies he needs, Lara said. For instance, the therapies provided by Joshua's school are not one-on-one, Lara said.

A new study highlights the unique financial burden faced by families of children with autism, like Lara's. The burden is particularly significant for mothers, the study finds.

On average, mothers of autistic children earn $14,755 less per year than mothers of healthy children, and $7,189 less per year than mothers of children with other health conditions (such as asthma and ADHD) that limit their ability to engage in childhood activities, according to the study.

Despite the fact that they tend to have completed more years of education, mothers of autistic children are 6 percent less likely to be employed, and they work on average 7 hours less weekly than mothers of healthy children, the researchers say.

"We don't think that autism creates more of a strain on the family per se than other chronic conditions of childhood," said study researcher David Mandell, associate professor of psychiatry and pediatrics at the University of Pennsylvania School of Medicine. "I think the reason these mothers are leaving the workforce is because the service system for children with autism is so fragmented," Mandell said.

Health care and workplace policies need to recognize the full impact of autism, and alleviate costs for the families with greatest needs, the researchers concluded, writing in the March 19 issue of the journal Pediatrics.

Higher bills, lower salaries

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Parents of Kids with Autism Earn Less

Mothers of kids with autism earn less

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By Kathleen Doheny HealthDay Reporter

MONDAY, March 19 (HealthDay News) -- Mothers of children with autism and autism spectrum disorders earn significantly less than what mothers of children who have no health limitations earn, a new study has found.

These moms even earn less than mothers of children with other health limitations.

Mothers of children with autism earned, on average, less than $21,000 a year, the researchers found. That was 56 percent less than mothers whose children had no health limitations and 35 percent less than mothers whose children had other health limitations.

In addition, moms who have children with autism are 6 percent less likely to be employed, and work an average of seven hours less per week than mothers of children with no health limitations, the study found.

While the researchers did not find differences in fathers' incomes, the overall income in families that have children with autism suffers, said lead researcher David Mandell, associate director of the Center for Autism Research at the Children's Hospital of Philadelphia and associate director of the Center for Mental Health Policy and Services Research at the University of Pennsylvania, in Philadelphia.

"Families of children with autism experience a 28 percent reduction in income compared to families with typically developing children," he said. The family incomes of parents whose children have autism is also less, 21 percent, than those whose children have other health limitations, Mandell found.

The study is published online March 19 and in the April print issue of Pediatrics.

For the study, Mandell and his colleagues looked at data from the 2002-2008 Medical Expenditure Panel Survey. This ongoing survey of U.S. households collects detailed information on medical conditions, health services use and expenditure, and other data.

The researchers looked at 261 children with autism spectrum disorders, nearly 3,000 with other health limitations and more than 64,000 with no health limitations.

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Mothers of kids with autism earn less

Mothers of Kids With Autism Earn Less, Study Shows

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MONDAY, March 19 (HealthDay News) -- Mothers of children with autism and autism spectrum disorders earn significantly less than what mothers of children who have no health limitations earn, a new study has found.

These moms even earn less than mothers of children with other health limitations.

Mothers of children with autism earned, on average, less than $21,000 a year, the researchers found. That was 56 percent less than mothers whose children had no health limitations and 35 percent less than mothers whose children had other health limitations.

In addition, moms who have children with autism are 6 percent less likely to be employed, and work an average of seven hours less per week than mothers of children with no health limitations, the study found.

While the researchers did not find differences in fathers' incomes, the overall income in families that have children with autism suffers, said lead researcher David Mandell, associate director of the Center for Autism Research at the Children's Hospital of Philadelphia and associate director of the Center for Mental Health Policy and Services Research at the University of Pennsylvania, in Philadelphia.

"Families of children with autism experience a 28 percent reduction in income compared to families with typically developing children," he said. The family incomes of parents whose children have autism is also less, 21 percent, than those whose children have other health limitations, Mandell found.

The study is published online March 19 and in the April print issue of Pediatrics.

For the study, Mandell and his colleagues looked at data from the 2002-2008 Medical Expenditure Panel Survey. This ongoing survey of U.S. households collects detailed information on medical conditions, health services use and expenditure, and other data.

The researchers looked at 261 children with autism spectrum disorders, nearly 3,000 with other health limitations and more than 64,000 with no health limitations.

About 67 percent of the children with autism had mothers who worked outside the home. About 92 percent of the kids with autism had working fathers.

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Mothers of Kids With Autism Earn Less, Study Shows

Cryo-Save Group N.V.: Revenue up 4% to EUR41.9 million

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Cryo-Save Group N.V. (Euronext: CRYO, Cryo-Save, or the Group), the leading international stem cell storage brand and the largest family stem cell bank in Europe, has published its financial results for the year ended 31 December 2011.

Financial highlights

Revenue up 4% to EUR41.9 million (2010: EUR40.4 million) Operating expenses before depreciation and amortisation increased with EUR1.6 million mainly due to further investments in Cryo-Lip() (EUR0.8 million) and acquisition impact (EUR0.7 million) EBITDA(*): EUR6.3 million (2010: EUR7.3 million) EBITA(**): EUR4.5 million (2010: EUR5.8 million) Operating profit: EUR2.9 million (2010: EUR4.5 million) Profit before taxation: EUR3.0 million (2010: EUR3.9 million) Net profit: EUR2.3 million (2010: EUR2.6 million) Basic earnings per share 25.0 euro cents (2010: 27.6 euro cents) Robust net cash from operating activities EUR6.2 million (2010: EUR 2.8 million) Solid cash position of EUR7.0 million as at 31 December 2011 (2010: EUR6.0 million) Dividend per share of EUR0.08, up 14% (2010: EUR0.07) () (*) EBITDA is defined as Earnings Before Interest, Taxation Depreciation and Amortisation (**) EBITA is defined as Earnings Before Interest, Taxation and Amortisation of identified intangible assets

Operational highlights

39,900 new samples stored in 2011, up 4% compared to previous year (2010: 38,300). Of these, 25,200 were new cord blood samples and 14,700 new cord tissue samples 204,000 samples have been stored in total at 31 December 2011 67% of new customers opt for combined service of cord blood and cord tissue storage Acquisition of Serbian distributor Life R.F. for EUR2.3 million in cash and 30,000 Cryo-Save shares Cryo-Save USA founded, to commercialize and develop the Cryo-Lip() service in North America Cryo-Save South Africa joint venture established and stem cell processing and storage laboratory opened in Cape Town together with John Daniel Holdings and Lazaron Biotechnologies A six-year-old girl from Portugal with Cerebral Palsy was treated at Duke University in the US with her own cord blood stem cells, which were stored and released by Cryo-Save

Outlook

* Cryo-Save has a strong strategic position and product portfolio to further enhance its business * Cryo-Save will continue to collaborate with new partners and make acquisitions in line with its strategy to grow in current markets as well as in new geographies * Promising developments continue in the use of stem cell technology in the treatment of diseases. Thus enhancing the added value of Cryo-Saves high- tech storage solutions of stem cells * Fast growing fields of cellular therapy and regenerative medicine offer further attractive market potential for Cryo-Save * The Group is confident it will continue to maintain its market leading position as the leading international stem cell storage brand and the largest family stem cell bank in Europe

Revenue increased with EUR1.4 million to EUR41.9 million, largely due to increased sales volumes in several countries, acquisitions and increased number of new cord tissue samples, partly offset by lower business volume in mainly Southern Europe. The impact of the economic crisis also resulted in a significantly lower number of births in almost all countries. An increasing demand for discounts on the service fee and instalment plans to facilitate the payment of the service fee has been another factor affecting revenue growth.

The gross profit margin decreased with 1% to 66.6%, among others due to an increased demand for higher reimbursements of the collection of the umbilical cord blood and cord tissue in the hospitals. The gross profit margin remained at the same level compared to the second half of 2010 (66.5%).

Operational expenses increased with EUR1.6 million due to incremental expenses related to Cryo-Lip() (EUR0.8 million), and the impact of the acquisitions of Tissue Bank Cryo Center Bulgaria AD ("TBCCB") and Life R.F. doo, Serbia ("Life") (EUR0.7 million).

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Cryo-Save Group N.V.: Revenue up 4% to EUR41.9 million

Huntington's Disease – Stem Cell Therapy Potential

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Editor's Choice Academic Journal Main Category: Huntingtons Disease Also Included In: Stem Cell Research Article Date: 19 Mar 2012 - 10:00 PDT

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4.5 (2 votes)

3 (1 votes)

However, according to a study published March 15 in the journal Cell Stem Cell, a special type of brain cell created from stem cells could help restore the muscle coordination deficits that are responsible for uncontrollable spasms, a characteristic of the disease. The researchers demonstrated that movement in mice with a Huntington's-like condition could be restored.

Su-Chun Zhang, a University of Wisconsin-Madison neuroscientist and the senior author of the study, said:

In the study Zhang, who is an expert in creating various types of brain cells from human embryonic or induce pluripotent stem cells, and his team focused on GABA neurons. The degradation of GABA cells causes the breakdown of a vital neural circuit and loss of motor function in individuals suffering from Huntington's disease.

According to Zhang, GABA neurons generate a vital neurotransmitter, a chemical that helps support the communication network in the brain that coordinates movement.

Zhang and his team at the UW-Madison Waisman Center, discovered how to generate large quantities of GABA neurons from human embryonic stem cells. The team's goal was to determine whether these cells would safely integrate into the brain of a mouse model of Huntington's disease.

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Huntington's Disease - Stem Cell Therapy Potential

Huntington’s Disease – Stem Cell Therapy Potential

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Editor's Choice Academic Journal Main Category: Huntingtons Disease Also Included In: Stem Cell Research Article Date: 19 Mar 2012 - 10:00 PDT

email to a friend printer friendly opinions

Current Article Ratings:

4.5 (2 votes)

3 (1 votes)

However, according to a study published March 15 in the journal Cell Stem Cell, a special type of brain cell created from stem cells could help restore the muscle coordination deficits that are responsible for uncontrollable spasms, a characteristic of the disease. The researchers demonstrated that movement in mice with a Huntington's-like condition could be restored.

Su-Chun Zhang, a University of Wisconsin-Madison neuroscientist and the senior author of the study, said:

In the study Zhang, who is an expert in creating various types of brain cells from human embryonic or induce pluripotent stem cells, and his team focused on GABA neurons. The degradation of GABA cells causes the breakdown of a vital neural circuit and loss of motor function in individuals suffering from Huntington's disease.

According to Zhang, GABA neurons generate a vital neurotransmitter, a chemical that helps support the communication network in the brain that coordinates movement.

Zhang and his team at the UW-Madison Waisman Center, discovered how to generate large quantities of GABA neurons from human embryonic stem cells. The team's goal was to determine whether these cells would safely integrate into the brain of a mouse model of Huntington's disease.

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Huntington's Disease - Stem Cell Therapy Potential

Cryo-Save Group N.V.: Revenue up 4% to €41.9 million

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Cryo-Save Group N.V. (Euronext: CRYO, `Cryo-Save`, or `the Group`), the leading international stem cell storage brand and the largest family stem cell bank in Europe, has published its financial results for the year ended 31 December 2011.

Financial highlights

Revenue up 4% to 41.9 million (2010: 40.4 million) Operating expenses before depreciation and amortisation increased with 1.6 million mainly due to further investments in Cryo-Lip (0.8 million) and acquisition impact (0.7 million) EBITDA*: 6.3 million (2010: 7.3 million) EBITA**: 4.5 million (2010: 5.8 million) Operating profit: 2.9 million (2010: 4.5 million) Profit before taxation: 3.0 million (2010: 3.9 million) Net profit: 2.3 million (2010: 2.6 million) Basic earnings per share 25.0 euro cents (2010: 27.6 euro cents) Robust net cash from operating activities 6.2 million (2010: 2.8 million) Solid cash position of 7.0 million as at 31 December 2011 (2010: 6.0 million) Dividend per share of 0.08, up 14% (2010: 0.07)

* EBITDA is defined as Earnings Before Interest, Taxation Depreciation and Amortisation ** EBITA is defined as Earnings Before Interest, Taxation and Amortisation of identified intangible assets

Operational highlights

39,900 new samples stored in 2011, up 4% compared to previous year (2010: 38,300). Of these, 25,200 were new cord blood samples and 14,700 new cord tissue samples 204,000 samples have been stored in total at 31 December 2011 67% of new customers opt for combined service of cord blood and cord tissue storage Acquisition of Serbian distributor Life R.F. for 2.3 million in cash and 30,000 Cryo-Save shares Cryo-Save USA founded, to commercialize and develop the Cryo-Lip service in North America Cryo-Save South Africa joint venture established and stem cell processing and storage laboratory opened in Cape Town together with John Daniel Holdings and Lazaron Biotechnologies A six-year-old girl from Portugal with Cerebral Palsy was treated at Duke University in the US with her own cord blood stem cells, which were stored and released by Cryo-Save

Outlook

Revenue increased with 1.4 million to 41.9 million, largely due to increased sales volumes in several countries, acquisitions and increased number of new cord tissue samples, partly offset by lower business volume in mainly Southern Europe. The impact of the economic crisis also resulted in a significantly lower number of births in almost all countries. An increasing demand for discounts on the service fee and instalment plans to facilitate the payment of the service fee has been another factor affecting revenue growth.

The gross profit margin decreased with 1% to 66.6%, among others due to an increased demand for higher reimbursements of the collection of the umbilical cord blood and cord tissue in the hospitals. The gross profit margin remained at the same level compared to the second half of 2010 (66.5%).

Operational expenses increased with 1.6 million due to incremental expenses related to Cryo-Lip (0.8 million), and the impact of the acquisitions of Tissue Bank Cryo Center Bulgaria AD ("TBCCB") and Life R.F. doo, Serbia ("Life") (0.7 million).

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Cryo-Save Group N.V.: Revenue up 4% to €41.9 million

California's stem cell agency ponders its future

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LOS ANGELES (AP) -- The creation of California's stem cell agency in 2004 was greeted by scientists and patients as a turning point in a field mired in debates about the destruction of embryos and hampered by federal research restrictions.

The taxpayer-funded institute wielded the extraordinary power to dole out $3 billion in bond proceeds to fund embryonic stem cell work with an eye toward treatments for a host of crippling diseases. Midway through its mission, with several high-tech labs constructed, but little to show on the medicine front beyond basic research, the California Institute for Regenerative Medicine faces an uncertain future.

Is it still relevant nearly eight years later? And will it still exist when the money dries up?

The answers could depend once again on voters and whether they're willing to extend the life of the agency.

Several camps that support stem cell research think taxpayers should not pay another cent given the state's budget woes.

"It would be so wrong to ask Californians to pony up more money," said Marcy Darnovsky of the Center for Genetics and Society, a pro-stem cell research group that opposed Proposition 71, the state ballot initiative that formed CIRM.

Last December, CIRM's former chairman, Robert Klein, who used his fortune and political connections to create Prop 71, floated the possibility of another referendum.

CIRM leaders have shelved the idea of going back to voters for now, but may consider it down the road. The institute recently submitted a transition plan to Gov. Jerry Brown and the Legislature that assumes it will no longer be taxpayer-supported after the bond money runs out. CIRM is exploring creating a nonprofit version of itself and tapping other players to carry on its work.

"The goal is to keep the momentum going," board Chairman Jonathan Thomas said in an interview.

So far, CIRM has spent some $1.3 billion on infrastructure and research. At the current pace, it will earmark the last grants in 2016 or 2017. Since most are multi-year awards, it is expected to stay in business until 2021.

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California's stem cell agency ponders its future

California’s stem cell agency ponders its future

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LOS ANGELES (AP) -- The creation of California's stem cell agency in 2004 was greeted by scientists and patients as a turning point in a field mired in debates about the destruction of embryos and hampered by federal research restrictions.

The taxpayer-funded institute wielded the extraordinary power to dole out $3 billion in bond proceeds to fund embryonic stem cell work with an eye toward treatments for a host of crippling diseases. Midway through its mission, with several high-tech labs constructed, but little to show on the medicine front beyond basic research, the California Institute for Regenerative Medicine faces an uncertain future.

Is it still relevant nearly eight years later? And will it still exist when the money dries up?

The answers could depend once again on voters and whether they're willing to extend the life of the agency.

Several camps that support stem cell research think taxpayers should not pay another cent given the state's budget woes.

"It would be so wrong to ask Californians to pony up more money," said Marcy Darnovsky of the Center for Genetics and Society, a pro-stem cell research group that opposed Proposition 71, the state ballot initiative that formed CIRM.

Last December, CIRM's former chairman, Robert Klein, who used his fortune and political connections to create Prop 71, floated the possibility of another referendum.

CIRM leaders have shelved the idea of going back to voters for now, but may consider it down the road. The institute recently submitted a transition plan to Gov. Jerry Brown and the Legislature that assumes it will no longer be taxpayer-supported after the bond money runs out. CIRM is exploring creating a nonprofit version of itself and tapping other players to carry on its work.

"The goal is to keep the momentum going," board Chairman Jonathan Thomas said in an interview.

So far, CIRM has spent some $1.3 billion on infrastructure and research. At the current pace, it will earmark the last grants in 2016 or 2017. Since most are multi-year awards, it is expected to stay in business until 2021.

Originally posted here:
California's stem cell agency ponders its future

An Introduction to the Stem Cell Niche: What is it, Really?

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Stem cell populations in the body live in stem cell niches, each different type of stem cell with its own niche. The niche supplies the necessary environment and many of the cues that direct stem cell activity, and this is why changes in the niche are possibly more important than changes in stem cells themselves when it comes to the decline of stem cell activity with aging. That decline causes a sort of corrosion of your tissues as stem cells increasingly fail to keep up with maintenance and repair - but the evidence to date suggests that those stem cells are generally still capable of doing their jobs, provided they are given their marching orders:

Surprisingly, this age-related decline in stem cell potency may be somewhat reversible. A team of Howard Hughes Medical Institute (HHMI) researchers has found that in old mice, a several-week exposure to the blood of young mice causes their bone marrow stem cells to act "young" again. ... The researchers have not yet isolated the blood-borne factors that can switch old stem cells back to a more youthful state, but their results are consistent with other recent studies that show stem-cell aging may be reversible.

Thus we have to look at the aging of stem cells in the context of the niche and the rest of the body, and we have to look at regenerative medicine for the old in a holistic way. While throwing stem cells at every problem seems to be fairly beneficial, based on the successes to date in first generation stem cell transplant therapies, it isn't enough in and of itself. Putting good stem cells into an age-damaged environment is not using them to their best effect.

But this all comes back to the question of just what a stem cell niche is anyway, and why the changes of aging change the way in which stem cells act within the body. Here is a good open access paper that provides an introduction to the niche and its importance, with some examples of various different stem cell and niche types throughout the body:

What does the concept of the stem cell niche really mean today?

Ideas about stem cells, and how they behave, have been undergoing a lot of change in recent years, thanks to developments in visualizing, monitoring, and manipulating cells and tissues. ... the detailed mechanisms underlying niche function are extremely varied. Niches may be composed of cells, or cells together with extracellular structures such as the extracellular matrix (ECM). They may be sources of secreted or cell surface factors [that] control stem cell renewal, maintenance, or survival. They may consist of just a single cell type, or a whole host of interacting cells. They may derive from cells outside the stem cell's lineage, or they may derive primarily from the stem cell's own descendents. In general, there seems to be much more consensus about the fact that stem cells invariably need niches than about the specific mechanisms by which niches do their jobs.

Why should a stem cell need a special environment? This is a pertinent question, given that none of the elementary processes that stem cells rely upon - growing, dividing, differentiating - are unique to stem cells. We can easily imagine three classes of answers:

One possibility is that there are demands placed on stem cells that necessitate special support for viability. For example, the need, imposed by cellular immortality, to minimize the accumulation of genetic damage, may drive stem cells to adopt a peculiar metabolic state that might force them to rely upon other cells nearby for sustenance. This 'nutritive' function of the niche remains a formal possibility, but in most systems few experimental data in support of it have so far emerged.

A second possibility is that niches are agents of feedback control. Recent studies tell us that stem cell pools are not slavishly maintained at a constant size by fixed, asymmetric divisions, but are usually capable of expanding or contracting and, even under homeostatic conditions, may face large stochastic fluctuations. The varied growth factors and cell surface molecules produced by niche cells may share the common goal of controlling stem cell pools. If this is the case, then the niche might best be thought of not simply as an environment conducive to stem cell functioning, but as an apparatus for communicating information about the state of a tissue back to the stem cells that maintain it. An important question to address would then be how niches obtain and relay such information.

A third possibility is that niches are instruments of coordination among tissue compartments. Some of the best evidence for this view comes from work on the hair follicle niche ... There, stem and progenitor cells responsible for maintenance of epidermis, pigmentation, hair, and connective and adipose tissue all interact in close proximity. A need to achieve tight coordination among these different cell populations may be the overriding reason for complex organization of this niche. The possibility that other niches may also be hubs of inter-lineage coordination is certainly an idea worth investigating.

The best case scenario for the future is that enacting the Strategies for Engineered Negligible Senescence to repair the known forms of cellular and molecular damage that occur with aging will cause stem cell niches to largely take care of themselves. In other words, under this scenario it turns out that the second possibility outlined in the quote above is the principal role for niches, and thus repairing the biological damage of aging in the body will cause the command and control mechanisms for stem cell populations to return to a youthful state.

Source:
http://www.longevitymeme.org/newsletter/latest_rss_feed.cfm

Considering Bypassing the Electron Transport Chain in Damaged Mitochondria

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Damaged mitochondria cause problems because their electron transport chains, the core mechanism by which they generate power for the cell, stop working the right way. That leads to a situation in which sub-par mitochondria in a cell are not recycled despite being damaged, and since they replicate like bacteria the bad mitochondria take over the cell. It goes downhill from there, and this whole process is one of the fundamental causes of aging. Ways of addressing this situation include repairing the mitochondria directly or working around their damage by creating replacements for the damaged parts of mitochondrial protein machinery elsewhere in the cell. Here is another line of research that looks at trying to minimize the consequences of that damaged machinery by providing substitute components, but with a different focus: "Mitochondrial dysfunction (primary or secondary) is detrimental to intermediary metabolism. Therapeutic strategies to treat/prevent mitochondrial dysfunction could be valuable for managing metabolic and age-related disorders. Here, we review strategies proposed to treat mitochondrial impairment. We then concentrate on redox-active agents, with mild-redox potential, who shuttle electrons among specific cytosolic or mitochondrial redox-centers. We propose that specific redox agents with mild redox potential improve mitochondrial function because they can readily donate or accept electrons in biological systems, thus they enhance metabolic activity and prevent reactive oxygen species (ROS) production. These agents are likely to lack toxic effects because they lack the risk of inhibiting electron transfer in redox centers. ... This view has been demonstrated by testing the effect of several redox active agents on cellular senescence. Methylene blue (MB) appears to readily cycle between the oxidized and reduced forms using specific mitochondrial and cytosolic redox centers. MB is most effective in delaying cell senescence and enhancing mitochondrial function in vivo and in vitro. Mild-redox agents can alter the biochemical activity of specific mitochondrial components, which then in response alters the expression of nuclear and mitochondrial genes. We present the concept of mitochondrial electron-carrier bypass as a potential result of mild-redox agents, a method to prevent ROS production, improve mitochondrial function, and delay cellular aging. Thus, mild-redox agents may prevent/delay mitochondria-driven disorders."

Link: http://www.ncbi.nlm.nih.gov/pubmed/22419586

Source:
http://www.longevitymeme.org/newsletter/latest_rss_feed.cfm

Exercising the Mind as a Basis for Therapy

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Just as physical exercise is beneficial, so too is exercising the mind. This open access paper examines structured mental exercise as a basis for therapy that might do at least some good for neurodegenerative disease patients: "Non-pharmacological intervention of memory difficulties in healthy older adults, as well as those with brain damage and neurodegenerative disorders, has gained much attention in recent years. The two main reasons that explain this growing interest in memory rehabilitation are the limited efficacy of current drug therapies and the plasticity of the human central nervous system and the discovery that during aging, the connections in the brain are not fixed but retain the capacity to change with learning. Moreover, several studies have reported enhanced cognitive performance in patients with neurological disease, following non-invasive brain stimulation [i.e., repetitive transcranial magnetic stimulation and transcranial direct current stimulation to specific cortical areas]. The present review provides an overview of memory rehabilitation in individuals with mild cognitive impairment and in patients with Alzheimer's disease with particular regard to cognitive rehabilitation interventions focused on memory and non-invasive brain stimulation. Reviewed data suggest that in patients with memory deficits, memory intervention therapy could lead to performance improvements in memory, nevertheless further studies need to be conducted in order to establish the real value of this approach."

Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297818/

Source:
http://www.longevitymeme.org/newsletter/latest_rss_feed.cfm