Researcher Alert: Opportunity for Fresh Appeal in $243 Million Disease Team Round


A tiny opening exists for scientists
who failed to win approval last month of their bids for $20 million
research awards from the California stem cell agency.

On July 26, the agency's governing
board okayed $151 million for eight scientists during a day filled
with emotional testimony from patients, as well as appeals by
researchers seeking reconsideration of rejection by grant reviewers
at the California Institute for Regenerative Medicine. The board also
asked reviewers to take a fresh look at five applications in its signature disease team round.
However, the board failed to act on
eight applications, meaning that they are still pending. Normally the
board will approve -- as a group -- one set of applications. Then, at
the same meeting, it will vote to reject another set of applications.
On July 26, however, the hard-pressed directors late in the
afternoon lost the supermajority quorum (65 percent) required to do
business and adjourned without acting on all the applications.
This situation rarely occurs on award
rounds. In our recollection, it has happened only once before
although there may have been other occasions.
That leaves an opening for more
researchers to ask the board to act favorably at its Sept. 5-6 meeting in San Francisco on applications rejected by reviewers. Money
is available. The July 26 round was budgeted for $243 million.
At the meeting last month, discussion
by directors provided several clues to appropriate avenues for
reconsideration. They were interested in appeals, formally called
extraordinary petitions, that brought genuinely new information to
the table. Serious errors in the reviews – something more than
differences of opinion – were of interest. Wide variance in the
spread of scientific scores on specific applications, including the
preliminary scores, also triggered directors' interest.
Researchers considering appeals would
be well-advised to listen to the audiocast of the meeting to hear the
discussion of appeals. The transcript of the meeting also should be
posted soon on the CIRM website, probably this week. The transcript
can be found via this page when it is posted. The audiocast
instructions can be found on the July 26 meeting agenda.
(The best available information on the
CIRM web site shows a Sept. 5-6 governing board meeting. However,
that schedule also shows other two day meetings earlier this year,
which actually have turned out to be only one day.)

Source:
http://californiastemcellreport.blogspot.com/feeds/posts/default?alt=rss

Bob Hoskins has Parkinson's disease, retiring from acting

(Reuters) - Veteran British actor Bob Hoskins, the star of Who Framed Roger Rabbit, said on Wednesday he had been diagnosed with Parkinson's disease and was retiring from acting.

"Bob Hoskins wishes to announce that he will be retiring from acting, following his diagnosis of Parkinson's disease last autumn. He wishes to thank all the great and brilliant people he has worked with over the years, and all of his fans who have supported him during a wonderful career," the actor's London representatives said in a statement.

"Bob is now looking forward to his retirement with his family, and would greatly appreciate that his privacy be respected at this time."

Hoskins, 69, started his career in the 1970s on British television shows such as Thick as Thieves and Rock Follies of '77 before moving into bigger film roles, such as 1980's The Long Good Friday and 1986's Mona Lisa, for which he earned a best actor Oscar nomination and won a Golden Globe award.

The Suffolk-born actor became a staple face in the British film industry, often playing Cockney-speaking characters in both comedy and drama genres with his trademark gravelly voice.

His big Hollywood break came in 1988 when he played Eddie Valiant in Who Framed Roger Rabbit, a role for which he received a Golden Globe nomination. He then went on to play roles in 1990's Mermaids and 1991's Hook.

Hoskins' most recent movie role was as one of the eight dwarves in this year's dark fairytale Snow White and the Huntsman, alongside Chris Hemsworth and Kristen Stewart.

Parkinson's disease is an incurable, degenerative neurological disorder whose sufferers include U.S. actor Michael J. Fox and former heavyweight boxing champion Muhammad Ali.

(Reporting By Piya Sinha-Roy in Los Angeles Editing by Jill Serjeant and Leslie Gevirtz)

Copyright (c) Reuters

Read more:
Bob Hoskins has Parkinson's disease, retiring from acting

Bob Hoskins has Parkinson’s disease, retiring from acting

(Reuters) - Veteran British actor Bob Hoskins, the star of Who Framed Roger Rabbit, said on Wednesday he had been diagnosed with Parkinson's disease and was retiring from acting.

"Bob Hoskins wishes to announce that he will be retiring from acting, following his diagnosis of Parkinson's disease last autumn. He wishes to thank all the great and brilliant people he has worked with over the years, and all of his fans who have supported him during a wonderful career," the actor's London representatives said in a statement.

"Bob is now looking forward to his retirement with his family, and would greatly appreciate that his privacy be respected at this time."

Hoskins, 69, started his career in the 1970s on British television shows such as Thick as Thieves and Rock Follies of '77 before moving into bigger film roles, such as 1980's The Long Good Friday and 1986's Mona Lisa, for which he earned a best actor Oscar nomination and won a Golden Globe award.

The Suffolk-born actor became a staple face in the British film industry, often playing Cockney-speaking characters in both comedy and drama genres with his trademark gravelly voice.

His big Hollywood break came in 1988 when he played Eddie Valiant in Who Framed Roger Rabbit, a role for which he received a Golden Globe nomination. He then went on to play roles in 1990's Mermaids and 1991's Hook.

Hoskins' most recent movie role was as one of the eight dwarves in this year's dark fairytale Snow White and the Huntsman, alongside Chris Hemsworth and Kristen Stewart.

Parkinson's disease is an incurable, degenerative neurological disorder whose sufferers include U.S. actor Michael J. Fox and former heavyweight boxing champion Muhammad Ali.

(Reporting By Piya Sinha-Roy in Los Angeles Editing by Jill Serjeant and Leslie Gevirtz)

Copyright (c) Reuters

Read more:
Bob Hoskins has Parkinson's disease, retiring from acting

Bob Hoskins reveals he is suffering from Parkinson's Disease as he announces retirement from acting career

His agent said Hoskins, 69, was given the diagnosis in the autumn and planned to spend time with his family Hoskins, from Suffolk in England, has played a range of roles since the 1970s, ranging from gangster films to comedy roles Parkinson's is a neurological condition which is thought to affect around 127,000 people in the UK and has no known cure

By David Wilkes

PUBLISHED: 11:06 EST, 8 August 2012 | UPDATED: 05:43 EST, 9 August 2012

Retiring: Bob Hoskins was given the diagnosis in the autumn. Announcing his retirement the star's agent said he planned to spent time with his family

Actor Bob Hoskins is retiring from showbusiness after being diagnosed with Parkinsons disease.

The announcement brings to an end a silver screen career which spanned four decades and included Hollywood hits such as Who Framed Roger Rabbit.

His most recent appearance was in Snow White and the Huntsman, released this year and starring Kristen Stewart.

Hoskins, 69, revealed his battle with the brain disorder yesterday, several months after his diagnosis.

A statement released by his agent said: 'Bob Hoskins wishes to announce that he will be retiring from acting, following his diagnosis of Parkinsons disease last autumn.

'He wishes to thank all the great and brilliant people he has worked with over the years, and all of his fans who have supported him during a wonderful career.

Read more from the original source:
Bob Hoskins reveals he is suffering from Parkinson's Disease as he announces retirement from acting career

Bob Hoskins reveals he is suffering from Parkinson’s Disease as he announces retirement from acting career

His agent said Hoskins, 69, was given the diagnosis in the autumn and planned to spend time with his family Hoskins, from Suffolk in England, has played a range of roles since the 1970s, ranging from gangster films to comedy roles Parkinson's is a neurological condition which is thought to affect around 127,000 people in the UK and has no known cure

By David Wilkes

PUBLISHED: 11:06 EST, 8 August 2012 | UPDATED: 05:43 EST, 9 August 2012

Retiring: Bob Hoskins was given the diagnosis in the autumn. Announcing his retirement the star's agent said he planned to spent time with his family

Actor Bob Hoskins is retiring from showbusiness after being diagnosed with Parkinsons disease.

The announcement brings to an end a silver screen career which spanned four decades and included Hollywood hits such as Who Framed Roger Rabbit.

His most recent appearance was in Snow White and the Huntsman, released this year and starring Kristen Stewart.

Hoskins, 69, revealed his battle with the brain disorder yesterday, several months after his diagnosis.

A statement released by his agent said: 'Bob Hoskins wishes to announce that he will be retiring from acting, following his diagnosis of Parkinsons disease last autumn.

'He wishes to thank all the great and brilliant people he has worked with over the years, and all of his fans who have supported him during a wonderful career.

Read more from the original source:
Bob Hoskins reveals he is suffering from Parkinson's Disease as he announces retirement from acting career

Symptoms of Parkinson's disease

By SPECIAL TO HERNANDO | Hernando Today Published: August 09, 2012 Updated: August 09, 2012 - 1:12 PM

Parkinson's disease symptoms and signs may vary from person to person. Early signs may be mild and may go unnoticed. Symptoms often begin on one side of your body and usually remain worse on that side, even after symptoms begin to affect both sides. Parkinson's signs and symptoms may include:

Tremor. Your tremor, or shaking, usually begins in your limb, often your hand or fingers. You may notice a back-and-forth rubbing of your thumb and forefinger, known as a pill-rolling tremor. One characteristic of Parkinson's disease is tremor of your hand when it is relaxed (at rest).

Slowed movement (bradykinesia). Over time, Parkinson's disease may reduce your ability to move and slow your movement. This may make simple tasks difficult and time-consuming. Your steps may become shorter when you walk, or you may find it difficult to get out of a chair. Also, your feet may stick to the floor as you try to walk, making it difficult to move.

Rigid muscles. Muscle stiffness may occur in any parts of your body. The stiff muscles can limit your range of motion and cause you pain.

Impaired posture and balance. Your posture may have become stooped, or you may have balance problems as a result of Parkinson's disease.

Loss of automatic movements. In Parkinson's disease, you may have a decreased ability to perform unconscious movements, including blinking, smiling or swinging your arms when you walk. You may no longer gesture when talking.

Speech changes. You often may have speech problems as a result of Parkinson's disease. You may speak softly, quickly, slur or hesitate before talking. Your speech may be more of a monotone, rather than with the usual inflections.

Writing changes. Writing may appear small and become difficult.

Medications typically markedly reduce many of these symptoms. These medications increase or substitute for a specific signaling chemical (neurotransmitter) in your brain: dopamine. People with Parkinson's disease have low brain dopamine concentrations.

See the article here:
Symptoms of Parkinson's disease

Symptoms of Parkinson’s disease

By SPECIAL TO HERNANDO | Hernando Today Published: August 09, 2012 Updated: August 09, 2012 - 1:12 PM

Parkinson's disease symptoms and signs may vary from person to person. Early signs may be mild and may go unnoticed. Symptoms often begin on one side of your body and usually remain worse on that side, even after symptoms begin to affect both sides. Parkinson's signs and symptoms may include:

Tremor. Your tremor, or shaking, usually begins in your limb, often your hand or fingers. You may notice a back-and-forth rubbing of your thumb and forefinger, known as a pill-rolling tremor. One characteristic of Parkinson's disease is tremor of your hand when it is relaxed (at rest).

Slowed movement (bradykinesia). Over time, Parkinson's disease may reduce your ability to move and slow your movement. This may make simple tasks difficult and time-consuming. Your steps may become shorter when you walk, or you may find it difficult to get out of a chair. Also, your feet may stick to the floor as you try to walk, making it difficult to move.

Rigid muscles. Muscle stiffness may occur in any parts of your body. The stiff muscles can limit your range of motion and cause you pain.

Impaired posture and balance. Your posture may have become stooped, or you may have balance problems as a result of Parkinson's disease.

Loss of automatic movements. In Parkinson's disease, you may have a decreased ability to perform unconscious movements, including blinking, smiling or swinging your arms when you walk. You may no longer gesture when talking.

Speech changes. You often may have speech problems as a result of Parkinson's disease. You may speak softly, quickly, slur or hesitate before talking. Your speech may be more of a monotone, rather than with the usual inflections.

Writing changes. Writing may appear small and become difficult.

Medications typically markedly reduce many of these symptoms. These medications increase or substitute for a specific signaling chemical (neurotransmitter) in your brain: dopamine. People with Parkinson's disease have low brain dopamine concentrations.

See the article here:
Symptoms of Parkinson's disease

Bob Hoskins suffering from Parkinson's Disease, announces retirement from acting

His agent said Hoskins, 69, was given the diagnosis in the autumn and planned to spend time with his family Hoskins, from Suffolk in England, has played a range of roles since the 1970s, ranging from gangster films to comedy roles Parkinson's is a neurological condition which is thought to affect around 127,000 people in the UK and has no known cure

By David Wilkes

PUBLISHED: 11:06 EST, 8 August 2012 | UPDATED: 05:43 EST, 9 August 2012

Retiring: Bob Hoskins was given the diagnosis in the autumn. Announcing his retirement the star's agent said he planned to spent time with his family

Actor Bob Hoskins is retiring from showbusiness after being diagnosed with Parkinsons disease.

The announcement brings to an end a silver screen career which spanned four decades and included Hollywood hits such as Who Framed Roger Rabbit.

His most recent appearance was in Snow White and the Huntsman, released this year and starring Kristen Stewart.

Hoskins, 69, revealed his battle with the brain disorder yesterday, several months after his diagnosis.

A statement released by his agent said: 'Bob Hoskins wishes to announce that he will be retiring from acting, following his diagnosis of Parkinsons disease last autumn.

'He wishes to thank all the great and brilliant people he has worked with over the years, and all of his fans who have supported him during a wonderful career.

View original post here:
Bob Hoskins suffering from Parkinson's Disease, announces retirement from acting

Bob Hoskins suffering from Parkinson’s Disease, announces retirement from acting

His agent said Hoskins, 69, was given the diagnosis in the autumn and planned to spend time with his family Hoskins, from Suffolk in England, has played a range of roles since the 1970s, ranging from gangster films to comedy roles Parkinson's is a neurological condition which is thought to affect around 127,000 people in the UK and has no known cure

By David Wilkes

PUBLISHED: 11:06 EST, 8 August 2012 | UPDATED: 05:43 EST, 9 August 2012

Retiring: Bob Hoskins was given the diagnosis in the autumn. Announcing his retirement the star's agent said he planned to spent time with his family

Actor Bob Hoskins is retiring from showbusiness after being diagnosed with Parkinsons disease.

The announcement brings to an end a silver screen career which spanned four decades and included Hollywood hits such as Who Framed Roger Rabbit.

His most recent appearance was in Snow White and the Huntsman, released this year and starring Kristen Stewart.

Hoskins, 69, revealed his battle with the brain disorder yesterday, several months after his diagnosis.

A statement released by his agent said: 'Bob Hoskins wishes to announce that he will be retiring from acting, following his diagnosis of Parkinsons disease last autumn.

'He wishes to thank all the great and brilliant people he has worked with over the years, and all of his fans who have supported him during a wonderful career.

View original post here:
Bob Hoskins suffering from Parkinson's Disease, announces retirement from acting

Bob Hoskins reveals Parkinson's disease, bows out

Veteran British actor Bob Hoskins, the star of films including Who Framed Roger Rabbit, says he has been diagnosed with Parkinson's disease and is retiring from acting.

Hoskins, 69, started his career in the 1970s on British television shows such as Thick as Thieves and Rock Follies of '77 before moving into bigger film roles, such as 1980's The Long Good Friday and 1986's Mona Lisa, for which he earned a best actor Oscar nomination and won a Golden Globe award.

"Bob Hoskins wishes to announce that he will be retiring from acting, following his diagnosis of Parkinson's disease last autumn.

"He wishes to thank all the great and brilliant people he has worked with over the years, and all of his fans who have supported him during a wonderful career," the actor's London representatives said in a statement.

"Bob is now looking forward to his retirement with his family, and would greatly appreciate that his privacy be respected at this time."

The Suffolk-born actor became a staple face in the British film industry, often playing Cockney-speaking characters in both comedy and drama genres with his trademark gravelly voice.

His big Hollywood break came in 1988 when he played Eddie Valiant in Who Framed Roger Rabbit, a role for which he received a Golden Globe nomination.

He then went on to play roles in 1990's Mermaids and 1991's Hook.

Hoskins' most recent movie role was as one of the eight dwarves in this year's dark fairytale Snow White and the Huntsman, alongside Chris Hemsworth and Kristen Stewart.

Parkinson's disease is an incurable, degenerative neurological disorder whose sufferers include US actor Michael J Fox and former heavyweight boxing champion Muhammad Ali.

The rest is here:
Bob Hoskins reveals Parkinson's disease, bows out

Bob Hoskins reveals Parkinson’s disease, bows out

Veteran British actor Bob Hoskins, the star of films including Who Framed Roger Rabbit, says he has been diagnosed with Parkinson's disease and is retiring from acting.

Hoskins, 69, started his career in the 1970s on British television shows such as Thick as Thieves and Rock Follies of '77 before moving into bigger film roles, such as 1980's The Long Good Friday and 1986's Mona Lisa, for which he earned a best actor Oscar nomination and won a Golden Globe award.

"Bob Hoskins wishes to announce that he will be retiring from acting, following his diagnosis of Parkinson's disease last autumn.

"He wishes to thank all the great and brilliant people he has worked with over the years, and all of his fans who have supported him during a wonderful career," the actor's London representatives said in a statement.

"Bob is now looking forward to his retirement with his family, and would greatly appreciate that his privacy be respected at this time."

The Suffolk-born actor became a staple face in the British film industry, often playing Cockney-speaking characters in both comedy and drama genres with his trademark gravelly voice.

His big Hollywood break came in 1988 when he played Eddie Valiant in Who Framed Roger Rabbit, a role for which he received a Golden Globe nomination.

He then went on to play roles in 1990's Mermaids and 1991's Hook.

Hoskins' most recent movie role was as one of the eight dwarves in this year's dark fairytale Snow White and the Huntsman, alongside Chris Hemsworth and Kristen Stewart.

Parkinson's disease is an incurable, degenerative neurological disorder whose sufferers include US actor Michael J Fox and former heavyweight boxing champion Muhammad Ali.

The rest is here:
Bob Hoskins reveals Parkinson's disease, bows out

Research and Markets: R&D Trends: Parkinson's Disease – Pipeline swells but a paradigm shift is unlikely in the mid-term

DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/r5jrks/randd_trends_park) has announced the addition of the "R&D Trends: Parkinson's Disease - Pipeline swells but a paradigm shift is unlikely in the mid-term" report to their offering.

Review of key trends in the development of new Parkinson's disease drugs across the seven major markets. Includes detailed analyses of the composition of the pipeline, clinical trial design, target product profile, and future treatment developments.

Since early 2011, R&D efforts in Parkinson's disease have been met with mixed success. In Q1 2012, the US FDA re-approved UCB's Neupro (rotigotine patch), and accepted the New Drug Application filing for Impax/GSK's IPX066 for idiopathic Parkinson's disease. Meanwhile, the development of eight late-stage pipeline candidates has been discontinued due to lacklustre efficacy.

Scope

Highlights

Key Topics Covered:

OVERVIEW

EXECUTIVE SUMMARY

CLINICAL PIPELINE OVERVIEW

Read the original post:
Research and Markets: R&D Trends: Parkinson's Disease - Pipeline swells but a paradigm shift is unlikely in the mid-term

Research and Markets: R&D Trends: Parkinson’s Disease – Pipeline swells but a paradigm shift is unlikely in the mid-term

DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/r5jrks/randd_trends_park) has announced the addition of the "R&D Trends: Parkinson's Disease - Pipeline swells but a paradigm shift is unlikely in the mid-term" report to their offering.

Review of key trends in the development of new Parkinson's disease drugs across the seven major markets. Includes detailed analyses of the composition of the pipeline, clinical trial design, target product profile, and future treatment developments.

Since early 2011, R&D efforts in Parkinson's disease have been met with mixed success. In Q1 2012, the US FDA re-approved UCB's Neupro (rotigotine patch), and accepted the New Drug Application filing for Impax/GSK's IPX066 for idiopathic Parkinson's disease. Meanwhile, the development of eight late-stage pipeline candidates has been discontinued due to lacklustre efficacy.

Scope

Highlights

Key Topics Covered:

OVERVIEW

EXECUTIVE SUMMARY

CLINICAL PIPELINE OVERVIEW

Read the original post:
Research and Markets: R&D Trends: Parkinson's Disease - Pipeline swells but a paradigm shift is unlikely in the mid-term

Update on Teva's Laquinimod – Analyst Blog

Referenced Stocks: BIIB, NVS, RRMS, SPA, TEVA

Teva Pharmaceutical Industries Ltd. ( TEVA ) and Active Biotech recently announced that they intend to commence a phase III study with their oral multiple sclerosis candidate, laquinimod. The study will be conducted under the US Food and Drug Administration's (FDA) Special Protocol Assessment (SPA) program.

The phase III study, CONCERTO, will be conducted in patients with relapsing-remitting multiple sclerosis (RRMS). Two doses of laquinimod (0.6 mg and 1.2 mg) will be evaluated in the study for up to 24 months with the primary endpoint being confirmed disability progression as measured by the Expanded Disability Status Scale (EDSS).

Laquinimod has been evaluated in two other phase III trials (ALLEGRO and BRAVO) earlier. The candidate is also being studied for Crohn's disease and lupus.

The successful development and launch of laquinimod would help strengthen Teva's multiple sclerosis drug portfolio. Being an oral formulation, laquinimod could provide an advantage over therapies that require injection or infusion.

Teva already has a multiple sclerosis product in its portfolio - Copaxone. Copaxone is approved for the reduction of the frequency of relapses in relapsing-remitting multiple sclerosis (RRMS), including patients who have experienced a first clinical episode and have MRI features consistent with multiple sclerosis.

Teva received some good news on the Copaxone patent infringement lawsuit front recently with favorable court rulings in the UK and the US. With these rulings, Copaxone should be protected from generic competition until September 2015.

The favorable rulings are a major positive for Teva. With Copaxone contributing 19.5% to total revenues in 2011, the earlier-than-expected entry of generic versions would have been a major setback for the company. Teva can now focus on extending Copaxone's life cycle.

We are pleased with Teva's efforts to expand its multiple sclerosis franchise. The multiple sclerosis market represents significant commercial potential. The disease is estimated to affect more than 400,000 people in the US. Worldwide, it is estimated that more than two million people may be suffering from multiple sclerosis.

Key players in the multiple sclerosis market include Biogen ( BIIB ) and Novartis ( NVS ) among others.

See more here:
Update on Teva's Laquinimod - Analyst Blog

Update on Teva’s Laquinimod – Analyst Blog

Referenced Stocks: BIIB, NVS, RRMS, SPA, TEVA

Teva Pharmaceutical Industries Ltd. ( TEVA ) and Active Biotech recently announced that they intend to commence a phase III study with their oral multiple sclerosis candidate, laquinimod. The study will be conducted under the US Food and Drug Administration's (FDA) Special Protocol Assessment (SPA) program.

The phase III study, CONCERTO, will be conducted in patients with relapsing-remitting multiple sclerosis (RRMS). Two doses of laquinimod (0.6 mg and 1.2 mg) will be evaluated in the study for up to 24 months with the primary endpoint being confirmed disability progression as measured by the Expanded Disability Status Scale (EDSS).

Laquinimod has been evaluated in two other phase III trials (ALLEGRO and BRAVO) earlier. The candidate is also being studied for Crohn's disease and lupus.

The successful development and launch of laquinimod would help strengthen Teva's multiple sclerosis drug portfolio. Being an oral formulation, laquinimod could provide an advantage over therapies that require injection or infusion.

Teva already has a multiple sclerosis product in its portfolio - Copaxone. Copaxone is approved for the reduction of the frequency of relapses in relapsing-remitting multiple sclerosis (RRMS), including patients who have experienced a first clinical episode and have MRI features consistent with multiple sclerosis.

Teva received some good news on the Copaxone patent infringement lawsuit front recently with favorable court rulings in the UK and the US. With these rulings, Copaxone should be protected from generic competition until September 2015.

The favorable rulings are a major positive for Teva. With Copaxone contributing 19.5% to total revenues in 2011, the earlier-than-expected entry of generic versions would have been a major setback for the company. Teva can now focus on extending Copaxone's life cycle.

We are pleased with Teva's efforts to expand its multiple sclerosis franchise. The multiple sclerosis market represents significant commercial potential. The disease is estimated to affect more than 400,000 people in the US. Worldwide, it is estimated that more than two million people may be suffering from multiple sclerosis.

Key players in the multiple sclerosis market include Biogen ( BIIB ) and Novartis ( NVS ) among others.

See more here:
Update on Teva's Laquinimod - Analyst Blog

Update on Teva's Laquinimod

Teva Pharmaceutical Industries Ltd. (TEVA) and Active Biotech recently announced that they intend to commence a phase III study with their oral multiple sclerosis candidate, laquinimod. The study will be conducted under the US Food and Drug Administrations (:FDA) Special Protocol Assessment (SPA) program.

The phase III study, CONCERTO, will be conducted in patients with relapsing-remitting multiple sclerosis (RRMS). Two doses of laquinimod (0.6 mg and 1.2 mg) will be evaluated in the study for up to 24 months with the primary endpoint being confirmed disability progression as measured by the Expanded Disability Status Scale (:EDSS).

Laquinimod has been evaluated in two other phase III trials (ALLEGRO and BRAVO) earlier. The candidate is also being studied for Crohns disease and lupus.

The successful development and launch of laquinimod would help strengthen Tevas multiple sclerosis drug portfolio. Being an oral formulation, laquinimod could provide an advantage over therapies that require injection or infusion.

Teva already has a multiple sclerosis product in its portfolio Copaxone. Copaxone is approved for the reduction of the frequency of relapses in relapsing-remitting multiple sclerosis (RRMS), including patients who have experienced a first clinical episode and have MRI features consistent with multiple sclerosis.

Teva received some good news on the Copaxone patent infringement lawsuit front recently with favorable court rulings in the UK and the US. With these rulings, Copaxone should be protected from generic competition until September 2015.

The favorable rulings are a major positive for Teva. With Copaxone contributing 19.5% to total revenues in 2011, the earlier-than-expected entry of generic versions would have been a major setback for the company. Teva can now focus on extending Copaxones life cycle.

We are pleased with Tevas efforts to expand its multiple sclerosis franchise. The multiple sclerosis market represents significant commercial potential. The disease is estimated to affect more than 400,000 people in the US. Worldwide, it is estimated that more than two million people may be suffering from multiple sclerosis.

Key players in the multiple sclerosis market include Biogen (BIIB) and Novartis (NVS) among others.

We currently have a Neutral recommendation on Teva, which carries a Zacks #3 Rank (short-term Hold rating).

The rest is here:
Update on Teva's Laquinimod

Update on Teva’s Laquinimod

Teva Pharmaceutical Industries Ltd. (TEVA) and Active Biotech recently announced that they intend to commence a phase III study with their oral multiple sclerosis candidate, laquinimod. The study will be conducted under the US Food and Drug Administrations (:FDA) Special Protocol Assessment (SPA) program.

The phase III study, CONCERTO, will be conducted in patients with relapsing-remitting multiple sclerosis (RRMS). Two doses of laquinimod (0.6 mg and 1.2 mg) will be evaluated in the study for up to 24 months with the primary endpoint being confirmed disability progression as measured by the Expanded Disability Status Scale (:EDSS).

Laquinimod has been evaluated in two other phase III trials (ALLEGRO and BRAVO) earlier. The candidate is also being studied for Crohns disease and lupus.

The successful development and launch of laquinimod would help strengthen Tevas multiple sclerosis drug portfolio. Being an oral formulation, laquinimod could provide an advantage over therapies that require injection or infusion.

Teva already has a multiple sclerosis product in its portfolio Copaxone. Copaxone is approved for the reduction of the frequency of relapses in relapsing-remitting multiple sclerosis (RRMS), including patients who have experienced a first clinical episode and have MRI features consistent with multiple sclerosis.

Teva received some good news on the Copaxone patent infringement lawsuit front recently with favorable court rulings in the UK and the US. With these rulings, Copaxone should be protected from generic competition until September 2015.

The favorable rulings are a major positive for Teva. With Copaxone contributing 19.5% to total revenues in 2011, the earlier-than-expected entry of generic versions would have been a major setback for the company. Teva can now focus on extending Copaxones life cycle.

We are pleased with Tevas efforts to expand its multiple sclerosis franchise. The multiple sclerosis market represents significant commercial potential. The disease is estimated to affect more than 400,000 people in the US. Worldwide, it is estimated that more than two million people may be suffering from multiple sclerosis.

Key players in the multiple sclerosis market include Biogen (BIIB) and Novartis (NVS) among others.

We currently have a Neutral recommendation on Teva, which carries a Zacks #3 Rank (short-term Hold rating).

The rest is here:
Update on Teva's Laquinimod

Pioneering music therapy for dementia patients developed in East Lancashire

Pioneering music therapy for dementia patients developed in East Lancashire

12:09pm Friday 10th August 2012 in News By Catherine Pye, Health reporter

DEMENTIA carers are being encouraged to whistle while they work as part of a new scheme to be launched in East Lancashire.

Burnley-based Crossroads Care East Lancashire are looking for about 20 families who want to take part in a trial of a technique called Music Therapy Care Giving (MTC).

The idea, which originated in Sweden, is that carers of dementia patients will be taught to sing while they carry out their day-to-day jobs, with the hope that the patient will join in too.

John Rattigan, trustee of Crossroads Care East Lancashire, is leading the scheme. He said: Research has found that this process leads to patients being more compliant, there is a reduction in medication, and people are being discharged from hospitals.

A grant from the National Gardens Scheme is funding the project, which will see volunteers trained in the technique. They will then go into peoples homes to pass on their skills to a carer.

Mr Rattigan said: For example, if I was looking after my wife at home, a volunteer from Crossroads would come round once a week to show me how to use singing.

They would discuss with me what kind of music my wife likes, from which era, and they would make sure that the songs chosen are ones that my wife is familiar with.

I, as a carer, would then start to sing as I carried out tasks like getting my wife dressed, or preparing food. The hope is that the patient will begin to join in with words and a melody they are familiar with.

See more here:
Pioneering music therapy for dementia patients developed in East Lancashire

Dementia patients use Montessori method

FENNVILLE, Mich. (WOOD) - What started as a method for teaching children to teach each other has been put to use to help local adults with dementia.

The Golden Orchards assisted living home in Fennville began implementing the Montessori method in January to help treat dementia patients. Thursday they hosted an open house to show their residents' progress.

In schools, Montessori is an approach to teaching that encourages a free-form style to learning in which older students help in teaching younger students, and the students themselves choosing what activities they want to do.

Dr. Cameron Camp, who was introduced to the Montessori method 15 years ago when his children started in a school that used the program, began developing uses for the dementia community.

"When people ask me what it is that I do, I say I enable persons with dementia to do what they're not supposed to be able to do," Dr. Camp told 24 Hour News 8 when he visited Golden Orchards. "We're not talking about a cure, that's a long way off. What we are talking about, however, is living, and trying to live well."

For adults living with dementia, these techniques can be used to help them try to regain lost motor skills, and give them a role to fill each day.

The staff at Golden Orchards said the focus on freedom during daily activities -- such as residents first setting up blocks then transitioning to story telling at their own will -- is helping them feel less agitated while increasing their motor skills.

In addition to their daily activities, residents also help set up meals for each other as a way of filling a specific role that they do each day.

Dr. Camp said this is part of how people with dementia can feel like they're contributing.

"It's about having a purpose-driven life," said Camp. "Especially to have a reason to wake up in the morning in spite of the fact you have a diagnosis."

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Dementia patients use Montessori method

Delirium increases the risk of developing new dementia 8-fold in older patients

Public release date: 8-Aug-2012 [ | E-mail | Share ]

Contact: Genevieve Maul Genevieve.maul@admin.cam.ac.uk 44-012-237-65542 University of Cambridge

Older people who have experienced episodes of delirium are significantly more likely to develop dementia, according to new research. The study is published in the journal Brain today, Thursday, 09August.

When in hospital, older people sometimes become acutely confused and disorientated. This condition, known as delirium, affects at least 15 per cent of older people in hospitals and has long thought to be simply a temporary side effect of other illness (such as an infection, a reaction to a medication or an operation). However, the new research shows that episodes of delirium can have long term effects - increasing the future risk of dementia eight-fold.

Dr Daniel Davis, lead author of the paper from the University of Cambridge, said: "This means that delirium, or the acute causes of delirium, could be a newly discovered cause of dementia. This is important, because although delirium is extremely common, less than a quarter of cases are actually diagnosed in hospitals."

Scientists at the University of Cambridge and the University of Eastern Finland recruited 553 people aged 85 and over, and assessed their memory and thinking over 10 years. Of the patients who had previously experienced at least one episode of delirium prior to the study, 77 per cent also had dementia. In comparison, only 33 per cent of the patients who had no previous history of delirium had dementia. They also recorded the number of episodes of delirium throughout the study.

In people without pre-existing dementia, experiencing delirium resulted in an eight-fold increase in the risk of dementia. In individuals with existing dementia, delirium was associated with an acceleration of dementia severity, loss of independence in physical functioning, and higher mortality.

Dr Davis added: "Worsening confusion and disorientation in older persons does not attract much attention among clinical staff and many believe that delirium is simply an inconvenient consequence of illness. However, this research suggests the possibility that delirium, or the problems giving rise to delirium, may be actually causing brain damage.

"Because some delirium is preventable, it is plausible that delirium prevention may lead to dementia prevention. We now urgently need to test if better delirium care can prevent dementia, or prevent further decline in patients who already have dementia."

The Wellcome Trust-funded study also found, for the first time, that there may be differences in the brains of people who have had delirium compared to those without delirium. Dementia is known to result from a several different pathological processes (e.g. accumulation of abnormal proteins, or blockages in blood vessels). However, this study found that when individuals had both delirium and dementia, these standard neuropathological markers were not enough to explain the dementia. This raises the important possibility that dementia occurring after delirium had alternative pathological processes causing the dementia.

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Delirium increases the risk of developing new dementia 8-fold in older patients