Monterey Newspaper Chides California Stem Cell Agency

The California stem cell agency and its
former chairman, Robert Klein, came under sharp criticism this week
in an editorial in the Monterey County Herald newspaper.
The editorial cited articles on the
California Stem Cell Report dealing with a $21,630 gift by Klein to
the agency, his employment of the vice chairman of the agency and the
violation of the agency's conflict of interest policies by a grant reviewer.
The editorial was headlined "State Stem Cell Agency Still Up to Old Tricks." The piece said,

“Robert Klein is no longer chairman
of California's stem cell bureaucracy, but it is still doing things
his way. Which is too bad for all concerned.

“Klein is the former developer and
financier who wrote and sponsored the ballot measure that created the
California Institute for Regenerative Medicine. The ballot language
practically guaranteed he would be the chairman, and he ran the
agency the way he ran his businesses, using undisclosed side deals
and other machinations to create webs that outsiders could never
penetrate.

“Now, Klein has been replaced as
chairman, but he is still up to his old tricks.”

The editorial concluded,

“Much has been said about the agency
setting a new more straightforward direction now that Klein is gone,
but so far it seems to be following a twisting and expensive path
toward irrelevance and litigation.”

Source:
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/SGmn7k9T1Vw/monterey-newspaper-chides-california.html

California's Alpha Stem Cell Clinics: Open in 2014, Six to Eight Locations

The San Francisco Business Times
yesterday said that the first Alpha Clinic sponsored by the $3
billion California stem cell agency could open as early as 2014.
The timing was disclosed by CIRM
President Alan Trounson in an article by Ron Leuty, who also reported
that that Trounson's $70 million proposal (see here and here) would involve as many as
six to eight clinics. The locations of the clinics was not disclosed
and would be subject to a competitive RFA. However, Leuty's piece
mentioned UC San Francisco and Stanford.
The article also said initial
treatments might focus on eye disease, “brain therapies” and
spinal cord injuries.
The Alpha Clinic plan is scheduled to
come before the CIRM board in late July. The proposal is aimed at
speeding stem cell treatments and creating something of a one-stop
shopping experience for patients.

Once the CIRM board approves the
concept, an RFA will be issued and interested institutions will have
to submit bids and compete for funding.  

Source:
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/So_NOlmLU2E/californias-alpha-stem-cell-clinics.html

California’s Alpha Stem Cell Clinics: Open in 2014, Six to Eight Locations

The San Francisco Business Times
yesterday said that the first Alpha Clinic sponsored by the $3
billion California stem cell agency could open as early as 2014.
The timing was disclosed by CIRM
President Alan Trounson in an article by Ron Leuty, who also reported
that that Trounson's $70 million proposal (see here and here) would involve as many as
six to eight clinics. The locations of the clinics was not disclosed
and would be subject to a competitive RFA. However, Leuty's piece
mentioned UC San Francisco and Stanford.
The article also said initial
treatments might focus on eye disease, “brain therapies” and
spinal cord injuries.
The Alpha Clinic plan is scheduled to
come before the CIRM board in late July. The proposal is aimed at
speeding stem cell treatments and creating something of a one-stop
shopping experience for patients.

Once the CIRM board approves the
concept, an RFA will be issued and interested institutions will have
to submit bids and compete for funding.  

Source:
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/So_NOlmLU2E/californias-alpha-stem-cell-clinics.html

$70 Million Alpha Stem Cell Clinic Proposal Draws Reader Comment

In addition to the comments filed online in connection with the $70 million proposal to create Alpha Clinics in California for stem cell treatments,  two other readers commented privately in emails. 
One came from a close observer of the
stem cell agency who said, “If done right -- and I'm sure you and I
agree that is a big 'if' – it could be an outstanding legacy.”
The other comment came from a
physician-researcher at a major California institution and was longer
and more critical. Here is the text.

“Another boondoggle for some medical
schools but made to order for private operators like for profit
cancer, dialysis, and laser eye specialty clinics that do one
procedure.  I can see each of the medical schools gifted with
one as they each were gifted with about 25 million dollars for stem
cell institute buildings; and CIRM and (Irv) Weissman's companies
like Stem Cells, Inc., getting a piece of the action as well.  Of
course the deans and chancellors on the CIRM steering committee will
vote for it. How can they not? It's money in their pockets.

“This has the fit and feel of, say,
old Latin American Laetrile clinics or offshore clinics offering
suspect surgeries or injections for cancers, Parkinson's disease, and
the like.  It makes no difference that they are set up in
California.  CIRM will pay for an unneeded infrastructure that
will be empty space and staff sitting on their hands 99% of the
time.  Or worse yet, CIRM will pay but the space will be used
for other things, other clinic procedures paid for by insurance.  

“Now (CIRM President Alan) Trounson and
CIRM want to get into the medical tourism business making California
a 'go-to place' for stem cell treatments.  They want to start
with bone marrow injections and transplants, procedures that cancer
centers do regularly.  All CIRM needs is a drug or treatment. 
It's not like there are tons of drugs out there and the only barrier
is the lack of clinical space and capacity.  The start up time
for any one drug is very long.

“NIH at various times has tried to
organize clinical trials groups with infrastructure, like quick
reaction forces, ready to gear up for a new trial at the drop of a
hat. They mainly did nothing but suck money, kept staff employed,
because there are generally few drugs ready for early human trials
and each treatment that is brought along requires a unique contract,
ethics reviews, and different facilities, equipment and staff than
planned for.  The latest incarnation are CTSAs or CTSIs,
clinical and translational science centers funded by the federal NIH
that most if not all California medical schools already have.

“The CIRM clinics are going to be
generic stem cell clinics advancing California tourism.  Come to
California, we will inject stem cells for any illness, in any part of
your body, never mind that cancer is different from heart disease is
different from bone disease is different from brain disease, no
matter.  Next step is for CIRM to form a travel agency with
discounted air and Ritz Carlton packages for patients and extended
family non-stop from China.  There is likely considerable
revenue to be generated here and Trounson, Weissman, and (Robert)
Klein
(former CIRM chairman) should find a way to benefit. It sounds
so wonderful!!  The public will love it.  Now all they need
are some treatments.  Love the name: Alpha Clinics, they
wouldn't want to start with Beta test clinics when they can go big
from the get-go.  What an irresponsible waste.”    

The other comments can be found at the end of the original item or in the column to the right of this item, headed "recent comments."

Source:
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/nKbicxl9mzA/70-million-alpha-stem-cell-clinic.html

Trounson Proposes $70 Million, Fast-Track Stem Cell Clinic Plan for California

Alan Trounson, president of the
California stem cell agency, this summer plans to seek $70 million
for creation of what he calls Alpha Clinics, high-powered
organizations that will fast-track stem cell therapies to patients.
The proposal is scheduled to come
before CIRM board at its meeting in late July and would consume a
significant slice of the $700 million to $800 million that the $3
billion agency has left to hand out.
Trounson broached the need for the
clinics as far back as two years ago, but did not put a price tag on
the concept until an interview published online late today in the Los
Angeles Times
. The interview will be carried in the print edition of
the paper tomorrow.
In the Q&A session between Times
columnist Patt Morrison and Trounson, he said, 

"I'm intending to set up a network of
stem cell clinics in California in the next couple of years, to make
treatments available as clinical trials or as registered treatments
for patients. I'm going to ask the [CIRM] board for about $70 million
to get that set up. It will make California a go-to place for stem
cell therapies. I want to make sure it's part of our medical fabric."

In other media reports in previous
years, Trounson has said the Alpha Clinics would speed delivery of
stem cell-based therapies and reduce costs of clinical trials by
building on the success of specialist cancer, transplant and in-vitro
fertilization clinics.
Leigh Dayton wrote about Trounson's
plan in The Australian last July 14. Dayton said,

“Initially the clinics would use the
capacities and infrastructure in the most advanced university medical
clinics to deliver bone-marrow stem cell therapies. As research
evolves, so will the treatments and services offered.”

Trounson also discussed the Alpha
Clinics during an appearance at USC in 2011. A university publication wrote,

"These clinics will initially serve
to get patients into clinical trials or to offer sound advice to
individuals who might otherwise go overseas to receive harmful stem
cell therapies from disreputable clinics.

"'I’m willing to invest money to
get these [clinics] up,' Trounson said. 'I think if nothing happens
beyond 2017 and we don’t get any refunding, we can leave a
footprint of stem cell clinics in California that will go on
forever.'"

Trounson was not at last week's CIRM
board meeting, but Ellen Feigal, senior vice president for research
and development, said a white paper is being prepared on Alpha
Clinics. She said a concept proposal would be brought to the board
July 25 at a meeting in the San Francisco Bay Area. Once the board
approves the concept, the staff will then prepare and post the RFA.

Interested parties can address
suggestions or questions to Feigal at info@cirm.ca.gov.

Source:
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/lND8J7NKqzc/trounson-proposes-70-million-fast-track.html

Sacramento Bee: Ongoing Conflict Problems No Help for Future Funding of Stem Cell Agency

The Sacramento Bee says conflict of
interest problems continue to trouble the California stem cell agency
despite its assertions that it has “turned a page” on the issues.
In an editorial Saturday, The Bee said
that CIRM Chairman Jonathan Thomas “has vowed to be aggressive in
avoiding conflicts in dispersing millions of public dollars for stem
cell research. Yet serious conflicts continue to be
revealed involving CIRM.”
The Bee cited articles on the
California Stem Cell Report earlier this month about a $21,630 gift
by its former chairman, Robert Klein, and the employment by Klein of
Vice Chairman Art Torres. The Bee said the situation “throws
into question a $20 million grant awarded last year to StemCells
Inc.
, a company that wants to transplant neural stem
cells to treat Alzheimer's
disease.” (See herehere and here)
The Bee also cited the case of Lee
Hood
, an internationally renown scientist who violated the agency's conflict of interest policy. Hood failed to disclose to CIRM a
conflict involving an application that he was reviewing on behalf of
the agency. The Bee said the agency's failure to detect the conflict
was “serious oversight."
Eight readers commented on the
editorial and agency, generally unfavorably about CIRM.
But reader “bchild” said,

“It took a couple years for them to start funding projects and it may take years to see results. Wall
Street got 1.5 trillion and the promise of 10x that if they get
into trouble again, the scientists (and their business buds) just
want a couple billion...In the end who do you trust more with
public money? At least there is the appearance of public benefit
here..."

The Bee concluded,

“None of this helps CIRM's reputation
in being fair and impartial in spending $3 billion in public funds.
It surely won't help the institute's standing with the Legislature
and the public, should it need help staying in operation when its
funding is exhausted in a few years.”

The editorial was also carried by at least one other paper in the McClatchy chain.

Source:
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/BZeSccFCbBU/sacramento-bee-ongoing-conflict.html

Brad Carter playing guitar during brain surgery – actor with parkinson's disease – 2013 – Video


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