Ocean chemistry changes triggered Earth’s greatest extinction event – Chemistry World (subscription)

The mixing of sulfide and oxygen-rich waters in the prehistoric Panthalassic Ocean contributed to the largest mass extinction of the last 540 million years. These new findings by Chinese and US researchers still have relevance today, as present-day climate change is exacerbating the growth of sulfidic zones in the worlds oceans.

Around 252 million years ago, the end-Permian event wiped out nearly all life on Earth in the most devastating extinction event in the planets history. More than 80% of marine species disappeared and it took several million years for these ecosystems to recover.

At this time the Panthalassic Ocean spanned 70% of the Earths surface. Today, the ocean floor that once sat under the Panthalassic has almost completely disappeared, with the only preserved sediments found in Canada, Japan and New Zealand. Using samples of fools gold found in these deposits, a team of geochemists led by Yanan Shen, of the University of Science and Technology of China, has tracked the changes in ocean chemistry that drove this catastrophic extinction event.

By analysing sulfur isotopes in pyrite minerals, the team concluded that the main killing agents were brought about by the mixing of sulfide-rich waters from the deep ocean with oxygenated shallow waters. Exactly what caused this increased mixing is still a mystery, however. Sulfide is toxic to eukaryotic cells and we know that hydrogen sulfide at concentrations of a few hundred parts per million would be lethal to humans, if exposed for a prolonged time, explains Shen. The shoaling of sulfidic waters, therefore, would kill marine animals in the PermianTriassic oceans.

Timothy Lyons, a biogeochemist from the University of California, Riverside, US, who was not involved in the research, describes the findings as tantalising. He explains that by measuring four different sulfur isotopes the researchers could fingerprint specific sulfur metabolic microbial pathways, gaining insight into the prehistoric oceans chemistry. When viewed in a temporal context, [the data] points to highly dynamic conditions and major perturbations to the marine system, he says. Evidence for episodic intrusions of sulfide into shallow waters may be the smoking gun for both the mass extinction and the protracted biotic recovery that followed.

Although the end-Permian extinction happened over a quarter of a billion years ago, the events that triggered it have added significance in the light of current-day climate change. Satellite remote sensing has clearly shown that massive fish mortality in the Namibian coastal waters are associated with sulfidic waters, says Shen. As a matter of fact, due to human-induced eutrophication and global warming, the episodic occurrence of hydrogen sulfide has been reported in many coastal waters such as those of the Gulf of Mexico, California and western India.

This warning is echoed by Lyons, who notes that there are lessons to be learned from this event, as we face warming in the present-day ocean.

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Will Biotechnology Regulations Squelch Food and Farming Innovation? – Genetic Literacy Project

Jon Entine, Executive Director, Genetic Literacy Project,oversaw the assignments and the editing of this series

INTRODUCTION:

Genetically engineered crops and animals (GMOs) have been a controversial public issue since the first products were introduced in the 1990s. They have posed unique challenges for governments to regulate. Although most working scientists in the field hold the opinion that genetic engineering, for the most part, is part of a continuum of the human manipulation of our food supply thats gone on for thousands of years, critics contend differently.

Many crop biotechnology skeptics frame their concerns in quasi-religious terms, as a violation of nature or fears that the increased use of GE foods will lead to a corporate takeover of our seed and food systems, and the adoption of an ecologically destructive industrialized agriculture system. GMOs have become a symbol of the battle over what our global, regional and local food systems should look like going forward.

The clout of the food movement that vocally rejects many aspects of conventional farming has exponentially increased since then, promoted by mainstream journalists, scientists and non-profit groups from Michael Pollan to Consumers Union to the Environmental Working Group. Organic leaders and lobbyists, such as Gary Hirshberg, founder of Stonyfield Organics and Just Label It, openly demonize conventional food and farming in defiance of their commitments agreed to in the 1990s that organic food would not be promoted at the expense of conventional agriculture. Attempts to reign in the unchecked influence of the conventional food critics have repeatedly failed; over much of the past decade, theyve had a sympathetic ear in Washington. Partly in response to the prevailing winds, the USDA has evolved increasingly byzantine regulatory structures when it comes to new GE products.

The Genetic Literacy Project 10-part series Beyond the Science II (Beyond the Science I can be viewed here) commences with this introductory article. Leading scientists, journalists and social scientists explore the ramifications of genetic engineering and so-called new breeding technologies (NBTs), specifically gene-editing technologies such as CRISPR. We will post two articles each week, on Tuesday and Wednesday, over the next 5 weeks.

Regulation is at the heart of this ongoing debate. Many scientists and entrepreneurs have come to view the two key agencies regulating GE in the United States the Food and Drug Administration and Department of Agriculture as places where innovation goes to die. Thats an exaggeration, but not without some truth; regulations are inherently political, and the winds have been blowing against technological breakthroughs in agriculture for much of the last decade. On average, it takes upwards of $125 million and 7-10 years for the Agriculture Department to approve a trait, exhausting almost half of a new products 20-year patent protection. No wonder the agricultural sector is consolidating, and most new products are innovated by larger corporations.

The regulatory climate may be changing, perhaps radically, in the United States and possibly in the United Kingdom, as the result of recent elections.

Many of the old rules and regulations regulating GE crops were set up in the 1980s and early 1990s. They are arguably creaky, overly-restrictive and do not account for dramatic increases in our understanding of how genetic engineering works and the now clear consensus on their safety.

Now with NBTs, which are largely unregulated since the techniques were not foreseen 30 years ago when regulations were first formulated, agricultural genetic research is at an inflection point: Will governments make the same mistake that they did previously and regulate innovation almost out of existence, or will they incorporate reasonable risk-risk and risk-benefit calculations in evaluating which technological advances should proceed with limited regulations?

Decisions on these issues will shape not only food and farming in Europe, North America and the industrialized nations, but the food insecure developing world, which looks to the West for regulatory guidance.

Gene Editing and Animals

The second article in our series, by University of California animal geneticist Alison Van Eenennaam, addresses the challenges of regulating genetically engineered animals. She focuses on dehorned cows, which have been developed without gene editing over many years with, at times, less than optimal results. Should gene editing be evaluated on a case-by-case basis triggered by the novelty of the traits, or should the entire process be heavily regulated the general approach favored by the European Union in regulating more conventional genetic engineering?

Pesticide Debate: How Should Agricultural Chemicals Be Regulated to Encourage Sustainability?

Dave Walton, an Iowa farmer, discusses the brouhaha that has erupted in recent years over the use of glyphosate, the active ingredient in the weed killer originally developed under patent by Monsanto. Many GMO critics are now expressing concerns over pesticide use in conventional agriculture, using glyphosate as a proxy for attacking the technology. Are their concerns appropriate? Walton, who grows both GE and non-GE crops and is director of the Iowa Soybean Association, has used glyphosate on his farm since the introduction of herbicide resistant crops in 1996. He uses on average a soda-sized cup of glyphosate per acre, and the use of the herbicide has allowed him to switch from more toxic chemicals. Most strikingly he discusses the sustainability impact if a glyphosate ban is imposed, as many activists are calling for.

Plant pathologist Steve Savage challenges us to think in a more nuanced way about a popular belief that organic farming is ecologically superior to conventional agriculture. The Agricultural Department has been a fractious mess in recent years in its efforts to oversee and encourage new breeding technologies. When the Clinton administration oversaw the founding of the National Organics Standards Board in 1995, USDA officials extracted the commitment from organic industry that the alternative farming system would not be promoted at the expense of conventional agriculture. After all, study after study, then and now, has established that organic farming offers no safety nor clear ecological benefits.

Let me be clear about one thing, said former Secretary of Agriculture Dan Glickman in December 2000. The organic label is not a statement about food safety, nor is organic a value judgment about nutrition or quality.

But thats not whats happened.

Regulations and the NGO Problem in Africa and Asia

While GE crops were pioneered in the United States and embraced in other western coun- tries outside of Europe, there has been resistance in regions of the world where these innovations could arguably bring the most impact: Africa and poorer sections of Asia. Ma- haletchumy Arujanan, executive director of Malaysian Biotechnology Information Centre and editor-in-chief of The Petri Dish, the first science newspaper in Malaysia, takes on the emerging Asian food security crisis posed by a parallel rise in population and living (and food consumption) standards. She reviews the successes and failures in various countries, and the effective campaigns by anti-GMO NGOs, mostly European funded, to block further biotech innovation.

Margaret Karembu, director of International Service for the Acquisition of Agribiotech Applications, Africa regional office (ISSSA) AfriCenter based in Nairobi, has found a similar pattern of mostly European-funded NGOs attempting to sabotage research and spread misinformation about the basic science of crop biotechnology. Africa is the ultimate organic experiment, and farmers have failed miserably using family agro-ecology techniques for decades. Cracks are beginning to form in the anti-GMO wall erected across the continent and there are hopes that young people will be attracted to farming, lured by the introduction of GE crops and other innovations.

Public Opinion and GMOs

Brandon McFadden, assistant professor in the Food and Resource Economics Department, University of Florida, addresses the complex views of consumers regarding innovation and GE foods. The public has a widely distorted perception of what genetic engineering entails, which helps explain why consumers remain so skeptical about technological innovation in farming.

Julie Kelly, a contributing writer to numerous publications including the Wall Street Journal, National Review and the GLP, takes on Hollywood in her analysis of the celebrity embrace of the anti-GMO movement. Who are the movers and shakers manipulating public opinion in favor of the organic movement and against conventional agriculture? Is the celebrity-backed science misinformation campaign working?

Future of GM Research and How the Public Debate May Evolve

Paul Vincelli, extension professor and Provosts Distinguished Service Professor at the University of Kentucky, has been perturbed about the attack on independent university researchers for working with the biotechnology industry over the years. By law, land grant university scientists are required to work with all stakeholders, particularly corporations who are developing the products used by farmers, including organic farmers. No, scientists who partner with corporations in research and product development are not shills. He rejects the knee jerk belief, advanced by many activist critics of GE crops, that corporate funding necessarily corruptsscience and should be banned.

Finally, risk expert David Ropeik has an optimistic take on the future. He believes 2016 may have been a turning point in the debate over GE foods. Technology rejectionists, from Greenpeace to labeling activists, are sounding increasingly shrill and less scientific. Gene editing, he believes, could undercut claims that GE foods are unsafe because they are unnatural. He is convinced, perhaps optimistically, that GE opponents will soon be viewed as science denialists.

We will see.

Anti-GMO critics cite opinion polls and the votes of anti-GMO legislators in Europe and elsewhere as proof that genetic engineering should be curtailed and more heavily regulated. Thats a rickety platform if one believes in science, however; science is not a popularity contest.

The Genetic Literacy Project is a 501(c)(3) non profit dedicated to helping the public, journalists, policy makers and scientists better communicate the advances and ethical and technological challenges ushered in by the biotechnology and genetics revolution, addressing both human genetics and food and farming. We are one of two websites overseen by the Science Literacy Project; our sister site, the Epigenetics Literacy Project, addresses the challenges surrounding emerging data-rich technologies.Jon Entineis the founder of the Science Literacy Project.

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Will Biotechnology Regulations Squelch Food and Farming Innovation? - Genetic Literacy Project

Insider Trading at Puma Biotechnology Inc? – Sports Perspectives

Insider Trading at Puma Biotechnology Inc?
Sports Perspectives
Puma Biotechnology logo Puma Biotechnology Inc (NYSE:PBYI) insider Robert Charnas sold 3,008 shares of the firm's stock in a transaction that occurred on Wednesday, February 1st. The stock was sold at an average price of $31.83, for a total transaction ...
Puma Biotechnology Inc Risk Points versus Health CareCML News
The Puma Biotechnology Inc (PBYI) Insider Sells $95744.64 in StockDailyQuint
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Top Biotechnology Stock Picking: Tenax Therapeutics, Inc. (TENX … – The Independent Republic

Tenax Therapeutics, Inc. (TENX) ended last trading session with a change of 1.3 percent. It trades at an average volume of 1.1M shares versus 3.36M shares recorded at the end of last trading session. The share price of $0.72 is at a distance of 73.16 percent from its 52-week low and down -75.56 percent versus its peak. The company has a market cap of $22.8M and currently has 31.73M shares outstanding. The share price is currently -61.84 percent versus its SMA20, -62.99 percent versus its SMA50, and -68.05 percent versus its SMA200. The stock has a weekly performance of -63.15 percent and is -63.15 percent year-to-date as of the recent close.

On January 31, 2017 Tenax Therapeutics, Inc. (TENX) announced top-line results from its Phase 3 LEVO-CTS trial. The study did not achieve statistically significant reductions in the dual endpoint of death or use of a mechanical assist device at 30 days, nor in the quad endpoint of death, myocardial infarction, need for dialysis, or use of a mechanical assist device at 30 days. However, the study demonstrated statistically significant reductions in two of three secondary endpoints including reduction in low cardiac output syndrome (LCOS) and a reduction in postoperative use of secondary inotropes. Patient visits for data on death through day 90 have not yet been completed. The Company has a meeting scheduled with the U.S. Food and Drug Administration (FDA) to review the preliminary trial data and discuss a path forward to bring this potentially lifesaving treatment to the benefit of patients undergoing serious cardiac surgery.

Intrexon Corporation (XON) recently recorded -2.77 percent change and currently at $21.43 is 5.1 percent away from its 52-week low and down -46.74 percent versus its peak. It has a past 5-day performance of 2.05 percent and trades at an average volume of 1.34M shares. The stock has a 1-month performance of -17.03 percent and is -11.81 percent year-to-date as of the recent close. There were about 118.35M shares outstanding which made its market cap $2.54B. The share price is currently -7.68 percent versus its SMA20, -17.93 percent versus its SMA50, and -19.97 percent versus its SMA200.

On Jan. 24, 2017 Intrexon Corporation (XON) announced that it has entered into a definitive agreement to acquire GenVec, Inc. (GNVC), a clinical-stage company and pioneer in the development of AdenoVerse gene delivery technology.

Intrexon intends to integrate and expand upon GenVecs expertise in adenoviral vectors and cGMP drug product manufacturing to enhance its broad gene transfer capabilities that encompass multiple viral and non-viral platforms. Notably, the combined technologies have the potential to yield the next generation of adenoviral (AdV) delivery through the creation of a scalable manufacturing platform utilizing helper-dependent adenovirus with significantly higher payload capacity of >30kb, as compared to current viral delivery methods ranging from 4.5kb 9kb.

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Top Biotechnology Stock Picking: Tenax Therapeutics, Inc. (TENX ... - The Independent Republic

NEXT: The Future of Manufacturing will be Driven by Automation and Bioengineering – columbusunderground

The Columbus Idea Foundry provides a glimpse of the future of manufacturing. The Idea Foundry is an expression of the maker movement, a renewed interest in things and objects, in making and manufacture, and in the skilled trades, which have been in decline over the past two generations.

Manufacturing at the Idea Foundry is smaller scale, based on batch processing, and on customizable, bespoke goods, not on the model of a giant factory with thousands of workers. In many ways, the Idea Foundry is a post-industrial enterprise that harkens back to pre-industrial patterns of manufacturing.

Where students now study computer science or software design, we could begin to see college students take the route toward manufacturing and making. That route, however, will not be the one that existed in the U.S. in the 1950s, where an 18-year old might graduate high school and the next day begin work in a factory. Todays manufacturing is hi-tech: look at the 3-D printers and other technologies found at the Idea Foundry. To operate such tools requires advanced skills.

The Massachusetts Department of Higher Education is already looking ahead to the workforce development needs for this advanced manufacturing. They announced their Advanced Manufacturing Workforce Plan in the Spring of 2015, which stated that [We must] look beyond the requirements of todays advanced manufacturing workforce to new and possibly higher-level competencies that will be required of the next generation workforce. While the current focus of workforce demand is centered on todays definition of the production manufacturing worker, accelerating advances in materials, technologies and supply chain processes will require a workforce with substantially new and different knowledge, skills and abilities to build the products of the future.

This means that four-year universities, not only technical and community colleges, must be geared up to train workers in advanced manufacturing skills.

As a measure of the high tech nature of manufacturing, much of what occurs in a factory is done by robots, machines and other forms of automation. Fewer workers monitor the technology that actually does the manufacturing.

Automation has always been the driving force in manufacturing after the Industrial Revolution: the historical trajectory has been the substitution of machines (capital) for human labor, and there is every reason to believe that long-term trend will continue unabated.

According to a McKinsey report, some 59 percent of all manufacturing activities could be automated, given technical considerationsWithin manufacturing, 90 percent of what welders, cutters, solderers, and brazers do, for example, has the technical potential for automation.

Returning manufacturing jobs from China and Mexico was a central feature of the Trump campaign, and indeed the President has taken some executive actions to reverse this and to bring some of these manufacturing jobs back to the U.S. But many economists have noted that job loss in manufacturing has been less the result of overseas outsourcing as it has from automation.

It is possible that President Trump will realize this reality, and if he remains committed to restoring manufacturing jobs, he might begin to institute policies to regulate automation. Might Trump insist that manufacturing be conducted by human laborers, else the companies using robots and other such technologies will be subject to taxes or other forms of retribution? Might consumers also begin to demand that the products they buy not only be Made in the USA but also Made by Human Hands? I think these are unlikely scenarios: it has been a truism of the Industrial Revolution that machines replace human labor, and I see no real challenge to that economic logic. But by the same token, some consumers have been demanding that foodstuffs not contain GMOs, and so it is possible that a similar sort of grass roots rejection of automated-manufactured goods could emerge.

We have long associated manufacturing with mechanical things: the production of automobiles, consumer goods, industrial materials. There is every reason to believe that the next phase of the Industrial Revolution will involve not only mechanical things but also the manufacture of biological objects.

Bioprinting is still in the experimental stage, but the technology promises the ability to print out living tissue, even human organs, through a process similar to the 3-D printers. Rather than printing off plastic objects, bioprinting involves spraying layer upon layer of cells in a manner similar to an ink-jet printer, thereby additively manufacturing living organs.

The initial uses for such biological objects will be for organic matter that will be used for drug testing. Rather than using lab animals, living human organsmanufactured organscan be tested instead. Some experiments have already produced manufactured arteries, and very soon manufactured liver cells might be injected into patients who are suffering from liver disease.

Ultimately, the goal is to be able to print an entirely new liver for a patient in need of a replacement. To work in this form of biological manufacturing will require advanced degrees in biology, chemistry and biological engineering.

All of this is by way of saying that manufacturing jobs in the future might just as likely involve the production of living, squishy, pulsating biological objects.

David Staley is president of Columbus Futuristsand a professor of history, design and educational studies at The Ohio State University. He is the host of CreativeMornings Columbus.

The next Columbus Futurists monthly forum will beThursday February 23 at 6:30 PMat the Panera Bread community room (875 Betel Rd.) Our topic for the evening will be Blockchain and the Future of the Internet.

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NEXT: The Future of Manufacturing will be Driven by Automation and Bioengineering - columbusunderground

Bike Share Program: Getting Around Campus on Two Wheels – UCR Today (press release)

Bike riders can use the Zagster bikes for free during the first two hours

By Sandra Baltazar Martinez on February 7, 2017

Bryan Marty Martinez, a fourth year student and current GCAP director, led a team of students to implement UCRs first Zagster bike share program. sandra baltazar martnez

Riding on two wheels to get from one end of campus to the other just got easier.

A few weeks ago, 50 new bicycles became available to all UC Riverside students, staff, and faculty members, via UCRs Zagster Bike Share program, UCRs first campuswide bike share program. The white bikes are parked at seven locations throughout the campus, including lot 30, Glen Mor, and near the HUB. They can be accessed by downloading an app on both iPhone andAndroid.

This program came together with the collaboration of Green Campus Action Plan (GCAP), Associated Students of UCR (ASUCR), Transportation and Parking Services (TAPS), and the Student Recreation Center (SRC). Procurement Services and Capital Planning also played key roles.

The real work started more than a year ago, with the vision of a former UCR undergraduate student Michael Ervin, who served asASUCR vice president of Campus Internal Affairs. Then, this past summer, fourth-year student and current GCAP Director Bryan Marty Martinez worked all summer to finalize logistics, contracts, and execution of the program.

When students returned from winter break, 50 Zagster bikes and 100 racks were in place. Theyve quickly becoming popular, probably because riders use the bike for free for the first two hours. After that, its $1 per hour, and charges cap at $6 per day. A local vendor has been contracted to service bikes, Martinez said.

Martinez, a sustainability studies major and political science minor, said GCAP is the primary funder of the bike share program because it wants to support UCRs bike-friendly atmosphere, as well as offer an inexpensive mode of transportation to the campus community.

Students can get to class on time, its environmentally friendly, and for commuters, it can help expedite their arrival to campus, Martinez said.

He also encourages staff and faculty members to pick up a bike. Why not? Everyone is doing it. You can improve your health, and getting used to riding a bike [again will be] like a childhood memory, Martinezsaid.

William Grover, assistant professor of bioengineering at the Bourns College of Engineering, decided to ride a bike on a recent January morning. sandra baltazar martnez

Assistant Professor of bioengineering at the Bourns College of Engineering, William Grover, is excited about having access to a bike on campus. This way he can bike to a meeting on the other side of campus, or ride to pick up lunch at University Village.

Groveris hopeful the bikes will help students arrive at his class on time, especially when walking from University Village.

On a recent afternoon, Grover checked out a bike and roamed the campus.

It made me realize how bike-friendly our campus is broad paths and car-free, really well suited for a bike share. I was surprised by how nice the bikes are lots of gears, easy-to-adjust seat, a little basket for storing stuff, even a bracket for holding the bike lock, Grover said.

William Grover, assistant professor of bioengineering, shows $0 charges after riding the bike.

For Jacquelyn I. Gonzlez, a graduate teaching assistant pursuing her masters in Public Policy, the bike share program and its free two-hour policy was great news.

When I came across the Zagster station by the HUB and saw that it was free for two hours, I knew I had found the solution to my commuter problem. And with my late night classes and study sessions, it has also given me a better sense of safety in getting to my car in lot 26, Gonzlez said.

Zagster is a Massachusetts-based company that offers bike share programs to cities, businesses, and universities. The contract with Zagster runsthrough January 2018. After that, the program will be evaluated based on usage and interest from students, staff, and faculty members, said Laurie Sinclair, ASUCR executive director.

The bike share program is meant to provide convenience for the campus community, Sinclair said. Its also meant to encourage and inspire sustainability.

Here is how it works:

To sign up and find the nearest Zagster location: ASUCR Website.

Archived under: Inside UCR, ASUCR, bike share program, Bryan Marty Martinez, GCAP, Jacquelyn I. Gonzlez, Laurie Sinclair, SRC, TAPS, William Grover, Zagster

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Biochemistry professor continues to follow passions at 100 years old – The Maneater

Eighty years ago, professor emeritus of biochemistry Boyd ODell began taking classes at MU. Now 100 years old, ODell, who has made many discoveries and inspired generations of colleagues, can still be found in his office in Eckles Hall.

I have some questions I really would like to answer, and Id rather think about answering those questions than retiring, ODell said.

ODell technically retired in 1988, but still does part-time research on campus.

In September, a celebration honoring the 40th anniversary of the biochemistry department served as an early 100th birthday party for ODell. In December, a plaque was unveiled, naming the bridge connecting Schweitzer Hall to the Schlundt Annex the Boyd ODell Bridge of Discovery.

I hope the bridge will be a bridge to the future for all the students and progress will be made in research and learning, ODell said at the unveiling.

Over the years, ODell has served as a mentor and a friend for many of his colleagues and students. Biochemistry professor Judy Wall first met ODell when she joined the MU faculty in 1978.

Hes an incredible gentleman, very professional, a great scholar and a truly kind person, Wall said.

Wall remembers when she and ODell were assigned to evaluate a graduate students grant proposal for a comprehensive exam. This was Walls first time evaluating this type of exam, and the only other female faculty member in the department did not attend their presentations.

I was the sole female faculty member and, you know, a silly person who was in the process of thinking about impressing all of my peers and making sure they didnt think I was an idiot at the evaluations, Wall said. So I was all set for getting this guy because I didnt think his proposal was great.

ODell went first. He discussed the importance of the problem the student had addressed and the strengths of the work before introducing criticism.

That was a wonderful experience for me because I thought thats exactly the way you should do it, Wall said. You have to earn the right to criticize by showing that you understand whats going on and you have to earn the right to begin to make constructive suggestions. Dr. ODell had shown me that was the professional way of going about it.

Wall uses this same approach anytime she has to evaluate anything in a similar manner.

He didnt realize, and I dont think I realized at the time, that he was mentoring me, but he certainly was, Wall said.

ODell decided to pursue education because he admired his teachers, who were his first role models.

I always had an ambition to be a teacher, ODell said. What did a farm boy in Carroll County have as role models? There was two things that I can think of, teacher was the most obvious one, and veterinarian.

ODell was born on a farm outside of Hale, Missouri, on Oct. 14, 1916. Becoming a veterinarian wasnt an option he considered, because it wasnt a financial possibility.

My parents were just poor farmers, and they couldnt help me, he said. I had to pave my way.

The summer after he graduated high school, ODell took an examination to become a teacher.

I passed all subjects with high scores except one, and that was pedagogy, ODell said. I didnt even know what pedagogy was. I suppose its the art of teaching.

That summer, ODell took classes at the University of Central Missouri, which was known as Warrensburg Teachers College at the time. He then began working in a one-room schoolhouse, where he taught first through eighth grade.

It was kind of fun in retrospect, ODell said. And that was in the depths of the Depression, to be paid $50 a month was a very good job. A lot of people were unable to even find a job.

Because he wanted to continue his education, ODell left the grade school after four years.

After a few years I transferred to the university here and got jobs one way or another and was able to support myself, he said.

He wanted to study bacteriology, but MU didnt have a program, so ODell was advised to become a chemistry major.

I worked for Dr. A.G. Hogan, who was my mentor for my Ph.D. At that time, he was interested in a vitamin that now is known as folic acid, ODell said.

ODell went on to work for a pharmaceutical company in Detroit after receiving his degree. With the end of World War II, MU saw an increase in students and invited ODell back to become a professor.

Coming back to Mizzou was kind of an easy choice because that was home. Im a Missourian through and through, ODell said.

ODell then studied the existence of unknown vitamins as an assistant professor.

At that time, an assistant professor was really an assistant to the professor, ODell said. When I became a little further along and had the independence, I still followed the question of, are there still unknown vitamins?

ODell went on to study the role of copper and zinc in the body. Among his discoveries was the revelation that copper deficiencies in animals can cause death through the rupture of the aorta, in the heart.

The opportunity arose for me to go on a sabbatical to Australia, ODell said. And why would I want to go to Australia? If youre interested in copper, its the place to go because much of the soil in Australia is copper-deficient.

In Australia, ODell saw that copper deficiency in sheep can cause symptoms similar to Parkinsons disease. He later observed the same results in rats.

We became interested in zinc deficiency around the same time, ODell said. We found that zinc deficiency in animals stops growth and causes increased subject to disease. Diarrhea is a common complaint of zinc-deficient animals and children.

He then discovered that phytic acid, which appears in plants such as soybeans and corn, can actually impact the way the body absorbs zinc.

Scientists want to know why does zinc deficiency cause these signs and symptoms in humans and animals, ODell said. Ive been interested in trying to solve that question for quite a number of years.

ODell is currently researching the importance of zinc in maintaining calcium channels.

If you think back of all the factors that a cell does, a cell divides, a cell secretes, contracts and carries messages, ODell said. All of this is dependent on a calcium channel, and if you take away zinc, the channel fails and you get all these symptoms. I think that that is the true, fundamental function of zinc to maintain the calcium channel.

ODell and Wall, a professor of biochemistry, have since worked together on a variety of committees and both taught biochemistry to first-year medical students.

He was always incredibly prepared, just beautiful lectures and so absolutely timely, Wall said. He knew the literature and was just great.

Another of ODells colleagues, professor emerita of biochemistry Grace Sun, also spoke of ODells role as a mentor.

Right now, Ive been retired for two years only and hes been retired for many more years, Sun said. I would say that hes a role model for me, and I wish I could do half as much like him.

The two became friends in the 80s, when a colleague Sun had met while working as a visiting professor in Taiwan came to MU to study with ODell.

ODell and his wife used to throw parties around the holidays where they would serve American foods, Sun said.

We loved it because we have a lot of international students and he has always a group of them, Sun said. At the time, he was like a hub for the international students.

Sun says ODell still interacts with colleagues and former research assistants by attending seminars and events on campus.

I remember one time, this must have been four or five years ago, and hes way over 90 and he wrote me an email, Sun said. He read a paper and then he said, Hey, Grace, maybe we can work together to do something on this area. I was so shocked. I was really amazed how he must be reading a lot of papers at home or in his office.

Now, ODell does experiments once or twice a week with cells that are grown in the Life Science Building.

I asked to use the equipment and I think they decided they better volunteer to do some of the work rather than trust me, ODell said with a laugh.

An undergraduate was assigned to help ODell grow and transfer the cells, Wall said.

It came holiday time, and the undergraduate was coming up on holiday, and so instead of imposing on this woman, Boyd decided he would just teach himself how to culture the human tissue culture, and so he did it, Wall said. Every day he would come over and transfer his cells and work with his cells. He walks over form Eckles to the Life Sciences Center and back again and has learned how to do this. What a terrifically fearless person he is when it comes to science.

ODell doesnt just walk across campus; he also walks from his house every time he comes to do research.

Most of my career I rode a bicycle to work, ODell said. I dont have a car, and I dont ride my bicycle anymore that leaves walking. I like walking. I think its good exercise, and I need exercise.

ODells daughter Ann, who lives in Columbia, helps drive him when he needs to go shopping and eats with him every week. ODell has a son, David, who lives in California, as well as four grandchildren and two great-grandchildren.

Outside of science, ODells hobbies include photography and bird-watching.

I was always interested in bird-watching and nature work; I guess that might fall from the science, ODell said. Even when I was teaching at the grade school, I had projects for the kids where wed collect plants.

After 100 years, ODell recognizes the importance of lifelong learning and following ones interests.

I think you should, in general even beyond science, you should pick a job or do what you have a real passion for, ODell said. I think if you really are keenly interested in it you will be successful.

Edited by Kyle LaHucik | klahucik@themaneater.com

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The Anatomy of Washington Husky Quarterback Jake Browning – FOXSports.com

Washington Husky Quarterback Jake Browning is recovering from surgery on his throwing shoulder. Heres why this is very good news

Quarterback Jake Browning led the Washington Huskies to the NCAA football playoffs. There, he ran into a tough Alabama defense and the team lost the game 24-7. But unknown to many, Browning was not up to 100%. In fact, he had injured his throwing shoulder early in the season in the home victory over Arizona State.

The following week, the Huskies would lose to the visiting USC Trojans 26-13. They would not lose another game until the playoffs.

In retrospect, his performance in the Arizona State and USC games were below average for the young hurler. With a season average rating of 167.5, his Arizona State win came in at 61.4 percent completion for 338 yards, two touchdowns and two interceptions for a rating of 131.8. The following week, he completed 37.5percent of his passes for 118yards twotouchdowns and zerointerceptions for a rating of 106.3. In the playoff game facing Alabama, he completed 52.6 percent of his passes for 150 yards, one touchdown and two interceptions for a rating of 83.9. All efforts contributed to the two season losses.

But an injury to the throwing shoulder can lead to below average performances. While we do not know the exact nature of the injury, we do know these facts:

So in summary, the injury is relatively minor. But based on the evidence, what is the most likely injury?

Nov 12, 2016; Seattle, WA, USA; Washington Huskies quarterback Jake Browning (3) lies on the turf following a 21-yard loss on a scramble against the USC Trojans during the fourth quarter at Husky Stadium. USC defeated Washington, 26-13. Mandatory Credit: Joe Nicholson-USA TODAY Sports

In summary, there are three types of soft tissues that could be mended with a minor surgical procedure: cartilage, ligaments, and tendons.

While cartilage is the plastic-like tissue that covers the ends of bones, acting like lubricant and shock absorbers, ligaments are the soft connective tissue that holds the joint together. Secondly, tendons are the soft connective tissues that anchor muscles to bones and joints. In the case of a minor shoulder injury, any of the three tissues could be injured.

Healing any of these types of injuries are similar in arthroscopic surgery. So lets discuss the process:

Phase I : Post Operative recovery This is the period of time immediately following surgery. Browningwill need to keep the shoulder as immobile as possible and to keep hisarm in a sling. The use of the sling keeps the weight of hisarm off of thesoft tissues which assists in the healing process. (through Feb 2017)

Phase II: Passive Physical Therapy For the next six to eight weeks, Browning enters passive physical therapy. Now he will work with a physical therapist to perform gentle, assisted exercises to help regain movement and range of motion inhis shoulder. Because damaged tissues are still actively healing,his shoulder joint needs to be supported during movement. (Mid April 2017)

Phase III: Active Physical Therapy Now the therapy changes from motion to strength. Browning will be tasked with building his shoulder strength gradually to avoid reinjury, but at an intensive pace to meet the demands of the 2017 football season. While this period will progress quickly, the minimum is likely to be three months time. (End July 2017)

Oct 8, 2016; Eugene, OR, USA; The University of Washington Huskies football team takes the field before the start of a game against the University of Oregon at Autzen Stadium. The Huskies won 70-21. Mandatory Credit: Troy Wayrynen-USA TODAY Sports

The Washington Husky Spring Football game will be held on Saturday, April 22nd. Its highly unlikely Jake Browning will be playing in that game. The team will likely have Tony Rodriguez, Jeff Lindquist, Blake Gregory, Daniel Bridge-Gadd and K.J. Carta-Samuels active for the game. The team also has 2017 recruit QB Jake Haener in the mix for the 2017 season.

It is very unlikely that Jake Browning will suit up for this game.

The Huskies regular season begins on September 1st on a coast to coast road trip to Piscataway, New Jersey to face the Rutgers Scarlet Knights. As of now, Browning will very likely be suited up and ready to go for the season opener.

With his shoulder fully healed, Browning should be far more effective to close out this season. It was the Seattle Times Adam Jude who first reported the shoulder injury to quarterback Jake Browning in mid January. He followed up with a second article on February 1 to confirm that Brownings status was determined to be doing well by head coach Chris Petersen.

Weve already had a plan you know, Jake is one of those guys that just loves to throw and throw and throw, Petersen said. So from really when he got here, weve been trying to back him off (after) these long years, to make sure. And so he should be fine for spring ball, but also want to give these other (quarterbacks) some really good work in spring ball. Chris Petersen per Adam Judes interview

And so, there was a little ambiguity here. Yes, Jake Browning is right on track. Yes, He will be fine for spring ball. He may even be throwing by then. But dont panic when he isnt suiting up for the annual Spring Football game.

He will be good, but he wont be THAT good.

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Grey’s Anatomy Round Table: Team Richard or Team Eliza? – TV Fanatic

We finally got to see what happened to Alex onGrey's Anatomy Season 13 Episode 11. Well, sort of.

After a standalone premiere, we returned to the hospital where Richard, Jackson, and April staged a mutiny against Eliza Minnick. Jo, still dealing with the news that Alex took the deal, was distracted and having a rough time on her shift. Ben took it upon himself to look after her.

Meredith spent the entire episode in search of Alex, only to find out that he was home sleeping in her bed the entire time.

Below, TV Fanatics Amanda, Tiffany, and Jasmine as they break down "Jukebox Hero."

They discuss their theories on how Alex evaded prison, what's going on with Jo and whether or not Amelia is behaving immaturely. They'll also talk about the mutiny and grade the episode.

Join the discussion!

Thoughts on the Alex reveal? What are you theories about how he avoided prison?

Amanda: Were we supposed to be surprised? There was no way he was going to prison. I thought it was fairly obvious that DeLuca must have dropped the charges. He seemed confused by Arizona's statement about never seeing Alex again.

Tiffany: The only thing I can come up with is maybe Deluca refused to testify for some reason and that hurt the prosecutions chances of proving their case to the point where they decided to drop the charges.

Maybe Alex told Deluca he was going to take the plea to protect Jo and maybe Deluca realized that's all Alex was ever trying to do. We know Deluca has feelings for Jo too so maybe he also wanted to protect her from her husband.

It's far-fetched but the show better have some explanation as to what happened because leading us on for so long then just dropping it is pretty frustrating.

Jasmine: Thanks to the comments jogging my memory, I recalled that Deluca was trying to tell Jo something. Most likely, it was that he dropped the charges, because he wanted to protect her. I guess that's the direction they're going in.

Interestingly enough, it still could be at the prosecution's discretion to charge him even if Deluca dropped the charges, and Alex would be the perfect candidate to "make an example out of it," but they have to find a way to write themselves out of this corner, so I guess that's the best route.

I agree that it was a pretty insane storyline to gives us and if it's not wrapped up in a decent way it will be frustrating.

Watch Grey's Anatomy Season 13 Episode 11 Online

Do you think Amelia is being childish, hiding out at Stephanie's house and avoiding Owen?

Amanda: A thousand times yes! Even if she thinks her marriage can't be saved, she should still act like a grown up and face Owen. Hiding out isn't going to fix or change anything. She's simply avoiding making the decision to either try to work things out or get a divorce.

Tiffany: I do. I've never been a huge fan of Amelia and this just makes her more annoying to me. If she would have been honest with Owen from the start, they could have worked through it together. It's not like she personally or intentionally killed her baby or its father. What happened to her was tragic. Owen would have understood.

Jasmine: Amelia is so much better than this. This storyline is bugging me too, because it's like the writers forgot that Amelia told Owen about her previous baby already! If he already knows about the baby, because she did tell him, than why is she suddenly clamming up and shutting him out now?

I don't understand why she can't talk to her own husband. They've had conversations confessing some of their deepest, darkest sins. It feels like unnecessary angst right now.

Quotables for Week Ending February 3, 2017

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Are you Team Eliza or Team Richard? What did you think about Richard and the gang's mutiny against Eliza and Bailey?

Amanda: While I'm not a fan of Eliza, Richard's mutiny doesn't help anything. Eliza is trying to do her job. The real issues Richard and the hospital staff have is with Bailey and they should be addressed to her and not Eliza.

Tiffany: Team Richard, always. Eliza is annoying and the way Bailey is handling the transition is just as bad.

Jasmine: Team Richard. The most irritating thing about Eliza, is she actually has valid reasons for changing things up, she just sucks at doing things properly. She's a very off-putting character and she's rude.

It seems like her mission right now is to just go after Richard. And Bailey is caught in the middle of this mess with Eliza, Richard, and Catherine, but there's a lot of things she didn't handle properly at all.

13 Indulgent Tub Scenes We'll Never Forget

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Jo nearly cost someone their life because she was too distracted with Alex's situation and then blew up at Ben. Is Jo becoming a liability? Or do you sympathize with her?

Amanda: She definitely didn't have her head in the game, and that's not a good thing at all. Hopefully she'll start paying attention to her patients again when she learns Alex isn't locked away. Also, her outburst at Ben was totally uncalled for, but she doesn't have the best track record of accepting help or a shoulder to lean on.

Tiffany: I still have hope for Jo but it's wearing thin. The writers need to start redeeming her soon.

Jasmine: I need someone to tell Jo to get her crap together. Jo needs a Christina Yang in her life. I would love to see the writers do something for her character.

23 TV Characters We DEMAND Return for 2016-17

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What would you grade the episode?

Amanda: I'd give it a B. I wasn't entirely invested in every patient storyline and the mutiny against Eliza got on my nerves. However, Meredith spending the day looking for Alex was realistic to watch, and I'm glad he is back home.

Tiffany: B-

Jasmine: I would give it a B+. The previous episodes were darker and heavier. I appreciated the fun that came with Richard's mutiny, and even Meredith spending the day trying to track down Alex. Even though I thought Amelia was being immature, I was entertained by her hiding at Stephanie's apartment.

The weird, gruesome hockey case was so very Grey's too. It all felt like throwback Grey's. Especially with the high schoolish shenanigans. Plus that Mer and and Alex scene at the end was too cute for words. Fingers crossed that Alex gets his Waffle Sundays now.

Do you agree with our Round Table? Let us know in the comments below!

You can watch Grey's Anatomy online here via TV Fanatic!

Grey's Anatomy Promo: "None of Your Business"

Jasmine Blu is a staff writer for TV Fanatic. Follow her on Twitter.

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Biochemistry professor continues to follow passions at 100 years old – The Maneater

Eighty years ago, professor emeritus of biochemistry Boyd ODell began taking classes at MU. Now 100 years old, ODell, who has made many discoveries and inspired generations of colleagues, can still be found in his office in Eckles Hall.

I have some questions I really would like to answer, and Id rather think about answering those questions than retiring, ODell said.

ODell technically retired in 1988, but still does part-time research on campus.

In September, a celebration honoring the 40th anniversary of the biochemistry department served as an early 100th birthday party for ODell. In December, a plaque was unveiled, naming the bridge connecting Schweitzer Hall to the Schlundt Annex the Boyd ODell Bridge of Discovery.

I hope the bridge will be a bridge to the future for all the students and progress will be made in research and learning, ODell said at the unveiling.

Over the years, ODell has served as a mentor and a friend for many of his colleagues and students. Biochemistry professor Judy Wall first met ODell when she joined the MU faculty in 1978.

Hes an incredible gentleman, very professional, a great scholar and a truly kind person, Wall said.

Wall remembers when she and ODell were assigned to evaluate a graduate students grant proposal for a comprehensive exam. This was Walls first time evaluating this type of exam, and the only other female faculty member in the department did not attend their presentations.

I was the sole female faculty member and, you know, a silly person who was in the process of thinking about impressing all of my peers and making sure they didnt think I was an idiot at the evaluations, Wall said. So I was all set for getting this guy because I didnt think his proposal was great.

ODell went first. He discussed the importance of the problem the student had addressed and the strengths of the work before introducing criticism.

That was a wonderful experience for me because I thought thats exactly the way you should do it, Wall said. You have to earn the right to criticize by showing that you understand whats going on and you have to earn the right to begin to make constructive suggestions. Dr. ODell had shown me that was the professional way of going about it.

Wall uses this same approach anytime she has to evaluate anything in a similar manner.

He didnt realize, and I dont think I realized at the time, that he was mentoring me, but he certainly was, Wall said.

ODell decided to pursue education because he admired his teachers, who were his first role models.

I always had an ambition to be a teacher, ODell said. What did a farm boy in Carroll County have as role models? There was two things that I can think of, teacher was the most obvious one, and veterinarian.

ODell was born on a farm outside of Hale, Missouri, on Oct. 14, 1916. Becoming a veterinarian wasnt an option he considered, because it wasnt a financial possibility.

My parents were just poor farmers, and they couldnt help me, he said. I had to pave my way.

The summer after he graduated high school, ODell took an examination to become a teacher.

I passed all subjects with high scores except one, and that was pedagogy, ODell said. I didnt even know what pedagogy was. I suppose its the art of teaching.

That summer, ODell took classes at the University of Central Missouri, which was known as Warrensburg Teachers College at the time. He then began working in a one-room schoolhouse, where he taught first through eighth grade.

It was kind of fun in retrospect, ODell said. And that was in the depths of the Depression, to be paid $50 a month was a very good job. A lot of people were unable to even find a job.

Because he wanted to continue his education, ODell left the grade school after four years.

After a few years I transferred to the university here and got jobs one way or another and was able to support myself, he said.

He wanted to study bacteriology, but MU didnt have a program, so ODell was advised to become a chemistry major.

I worked for Dr. A.G. Hogan, who was my mentor for my Ph.D. At that time, he was interested in a vitamin that now is known as folic acid, ODell said.

ODell went on to work for a pharmaceutical company in Detroit after receiving his degree. With the end of World War II, MU saw an increase in students and invited ODell back to become a professor.

Coming back to Mizzou was kind of an easy choice because that was home. Im a Missourian through and through, ODell said.

ODell then studied the existence of unknown vitamins as an assistant professor.

At that time, an assistant professor was really an assistant to the professor, ODell said. When I became a little further along and had the independence, I still followed the question of, are there still unknown vitamins?

ODell went on to study the role of copper and zinc in the body. Among his discoveries was the revelation that copper deficiencies in animals can cause death through the rupture of the aorta, in the heart.

The opportunity arose for me to go on a sabbatical to Australia, ODell said. And why would I want to go to Australia? If youre interested in copper, its the place to go because much of the soil in Australia is copper-deficient.

In Australia, ODell saw that copper deficiency in sheep can cause symptoms similar to Parkinsons disease. He later observed the same results in rats.

We became interested in zinc deficiency around the same time, ODell said. We found that zinc deficiency in animals stops growth and causes increased subject to disease. Diarrhea is a common complaint of zinc-deficient animals and children.

He then discovered that phytic acid, which appears in plants such as soybeans and corn, can actually impact the way the body absorbs zinc.

Scientists want to know why does zinc deficiency cause these signs and symptoms in humans and animals, ODell said. Ive been interested in trying to solve that question for quite a number of years.

ODell is currently researching the importance of zinc in maintaining calcium channels.

If you think back of all the factors that a cell does, a cell divides, a cell secretes, contracts and carries messages, ODell said. All of this is dependent on a calcium channel, and if you take away zinc, the channel fails and you get all these symptoms. I think that that is the true, fundamental function of zinc to maintain the calcium channel.

ODell and Wall, a professor of biochemistry, have since worked together on a variety of committees and both taught biochemistry to first-year medical students.

He was always incredibly prepared, just beautiful lectures and so absolutely timely, Wall said. He knew the literature and was just great.

Another of ODells colleagues, professor emerita of biochemistry Grace Sun, also spoke of ODells role as a mentor.

Right now, Ive been retired for two years only and hes been retired for many more years, Sun said. I would say that hes a role model for me, and I wish I could do half as much like him.

The two became friends in the 80s, when a colleague Sun had met while working as a visiting professor in Taiwan came to MU to study with ODell.

ODell and his wife used to throw parties around the holidays where they would serve American foods, Sun said.

We loved it because we have a lot of international students and he has always a group of them, Sun said. At the time, he was like a hub for the international students.

Sun says ODell still interacts with colleagues and former research assistants by attending seminars and events on campus.

I remember one time, this must have been four or five years ago, and hes way over 90 and he wrote me an email, Sun said. He read a paper and then he said, Hey, Grace, maybe we can work together to do something on this area. I was so shocked. I was really amazed how he must be reading a lot of papers at home or in his office.

Now, ODell does experiments once or twice a week with cells that are grown in the Life Science Building.

I asked to use the equipment and I think they decided they better volunteer to do some of the work rather than trust me, ODell said with a laugh.

An undergraduate was assigned to help ODell grow and transfer the cells, Wall said.

It came holiday time, and the undergraduate was coming up on holiday, and so instead of imposing on this woman, Boyd decided he would just teach himself how to culture the human tissue culture, and so he did it, Wall said. Every day he would come over and transfer his cells and work with his cells. He walks over form Eckles to the Life Sciences Center and back again and has learned how to do this. What a terrifically fearless person he is when it comes to science.

ODell doesnt just walk across campus; he also walks from his house every time he comes to do research.

Most of my career I rode a bicycle to work, ODell said. I dont have a car, and I dont ride my bicycle anymore that leaves walking. I like walking. I think its good exercise, and I need exercise.

ODells daughter Ann, who lives in Columbia, helps drive him when he needs to go shopping and eats with him every week. ODell has a son, David, who lives in California, as well as four grandchildren and two great-grandchildren.

Outside of science, ODells hobbies include photography and bird-watching.

I was always interested in bird-watching and nature work; I guess that might fall from the science, ODell said. Even when I was teaching at the grade school, I had projects for the kids where wed collect plants.

After 100 years, ODell recognizes the importance of lifelong learning and following ones interests.

I think you should, in general even beyond science, you should pick a job or do what you have a real passion for, ODell said. I think if you really are keenly interested in it you will be successful.

Edited by Kyle LaHucik | klahucik@themaneater.com

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BHRT: A match made in anti-aging – ModernMedicine

Dr. LightCosmetic surgery and hormone replacement address the same issue from different vantage points. As such, bioidentical hormone replacement therapy, or BHRT, is a powerful tool that should be incorporated into all successful cosmetic practices, according to Kevin Light, DO, MBA, a cosmetic surgeon and age management specialist in Dallas, Texas. Dr. Light presented Bioidentical Hormone Replacement Therapy and the Cosmetic Surgery Practice yesterday at the American Academy of Cosmetic Surgerys (AACSs) 2017 annual scientific meeting in San Diego, Calif. Dr. Light, author of the book OutSmart Aging, tells Cosmetic Surgery Times that, from a cosmetic perspective, aging negatively impacts the skin, with thinning, wrinkling, age spots and pigmentation, as well as loss of elasticity, resiliency and glow. Cosmetic aging results in soft tissue volume loss, in the face, breast and abdomen. It also results in bone loss, or shrinkage of the skull and mandible; hair loss, weight gain and fat redistribution. Hormone loss causes impaired wound healing and immune function, which can impact cosmetic surgery patients. Hormone loss also results in quality of life issues, from energy and sleep, to concentration, memory, libido and sexual function, he says. BHRT can halt or reverse all of this. This is no longer 'magic' and is well documented in the literature, Dr. Light says. From a business perspective, bioidentical hormone therapy is a $15 billion business and trending positively, Dr. Light says. Patients are aware of it and are demanding it. Several early adopter plastic and cosmetic surgeons around the country already offer it, Dr. Light says. BHRT is a powerful adjunct to age management and enhances patient 'stickiness' for the cosmetic surgery practice. The business model is easy and can be delegated to others. It presents incredible cross-sell opportunities.

NEXT: Dr. Lights Tips for Getting Started

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Marketing Immortality – JSTOR Daily

Weve long been fascinated with the ideas of immortality and eternal youth. Around 220 BCE, Emperor Shihuangdi searched for the elixir of life. Juan Ponce de Len searched for the Fountain of Youth in the 1500s, and in 1890, Oscar Wildes Dorian Gray sold his soul for a perpetually pretty face. The Methuselah Mouse Prize, an award granted to teams that engineer older and healthier mice, took the fantasy out of our myths and put it into our laboratories.

Recently, a controversial $8,000 blood transfusion treatment shows that its also moved into our clinics.

Anti-aging technology isnt limited to groundbreaking medicine.

The provider, Jesse Karmazin, based the idea on a study that suggested aging in mice could be reversed, after old mice that were given blood from young ones for four weeks showed changes in hallmark signs of getting older. Participants can pay for an infusion of young peoples blood and plasma in the hopes itll rejuvenate their own systems.The study itself is unreliable, the treatment unproven, and the cost toclients is astronomical. Karmazin himself isnt a medical professional, but an entrepreneur who sees anti-aging research as a market opportunity. The business has the potential to garner $4.8 million.

Anti-aging technology isnt limited to groundbreaking medicine. It lines pharmacies and makeup counters. Wrinkle creams, skin repair formulas, vitamins, Viagra; these are small but concrete examples of the money poured into researching, packaging, and selling youth.Our aversion to aging has enabled the commercialization of immortality, despite its impossibility.

Given our current enthusiasm for staving it off, we may not realize age didnt always terrify us, perhaps because we didnt live long enough for it to.

Senectitude in 1481 originally meant old age; senescence was used in 1695 to mean growing old; and senile was used in 1661 to signify what was suited to old age. The term senility was used in 1791 to mean a state of being old or infirm due to old age. But by 1848 senile meant weakness, and by the late nineteenth century it indicated a pathological state. The term has taken on greater medical negative connotations ever since.

As our lives have grown longer, life span and health span have become crucially different. Although age brings benefitsfamilies, wisdom, stabilitythe accompanying physical degeneration, and its correlating limitations, make us hyperfocused on old ageas the signpost for the approaching end of life.

The fixation on defeating death has had the sideeffect of vilifying age. John A. Vincent writes, science as culture misdirects the way in which old age is understood. Rather than valuing life in all its diversity, including its final phase, it leads to misguided devotion of resources to solving the problem of death. The focus on biological failure sets up a cultural construction of old age which leads to the low esteem in which it is currently held.

Our desire for youth isnt just a fear of dying; its the desire to keep a life worth living, and for us, that means immortality is not merely living to 150. It means living to 150, perpetually age 30.

By: John A. Vincent

Sociology, Vol. 40, No. 4 (AUGUST 2006), pp. 681-698

Sage Publications, Ltd.

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Malin stakes 32% take in US biotechnology company Artizan – Irish Times

Dublin-based Malin invested in US biotechnology company Artizan Biosciences via a funding round

Irish-based life sciences company Malin said on Monday it has acquired a 32 per cent shareholding of US biotechnology company Artizan Biosciences.

Dublin-based Malin, which has invested more than 300 million in life sciences companies since it was established in early 2015, invested in Artizan via a founding equity round alongside Hatteras Venture Partners, a venture capital firm with which Malin has a strategic partnership.

Artizan is a newly created biotechnology company headquartered in Durham, North Carolina, with labs in New Haven, Connecticut, that was founded to address diseases involving the human intestinal microbiota.

It was spun out of Yale University and established as a standalone business in 2016. Its founders include Prof Richard Flavell, Noah Palm, PhD, and Marcel de Zoete, PhD, from Yale University.

Artizan, which aims to be a leader in the microbiota-driven inflammatory diseases space, has developed a capability of distinguishing certain pathogenic bacteria from the remainder of the intestinal microbiota.

The ability to target these specific bacteria could lead to treatment options for any number of digestive disorders as well as other diseases including obesity, autoimmune disease and a wide variety of skin, lung and central nervous system diseases.

Artizans proposed approach is disruptive to current treatment and would offer new and novel therapeutic options for patients suffering from a broad array of inflammatory disorders, Adrian Howd, chief investment officer of Malin, said.

Last month Malin acquired a 33 per cent shareholding of Wren Therapeutics, a newly created biopharmaceutical company based in Cambridge, England. It was set up by a number of former Elan executives in 2015.

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Two Biotechnology Names Are Hot: Merrimack Pharmaceuticals, Inc. (MACK), MannKind Corporation (MNKD) – The Independent Republic

Merrimack Pharmaceuticals, Inc. (MACK) ended last trading session with a change of 0.96 percent. It trades at an average volume of 4.05M shares versus 1.35M shares recorded at the end of last trading session. The share price of $3.17 is at a distance of 12.01 percent from its 52-week low and down -64.86 percent versus its peak. The company has a market cap of $399.07M and currently has 125.89M shares outstanding. The share price is currently 0.08 percent versus its SMA20, -26.55 percent versus its SMA50, and -41.42 percent versus its SMA200. The stock has a weekly performance of 3.59 percent and is -22.3 percent year-to-date as of the recent close.

On Jan. 18, 2017 Merrimack Pharmaceuticals, Inc. (MACK) announced that Richard Peters, M.D., Ph.D., has been appointed as the Companys President and Chief Executive Officer, effective February 6, 2017, at which time he will also be appointed to the Merrimack Board of Directors. Dr. Peters will join Merrimack from his current role at Sanofi Genzyme, where he serves as Senior Vice President and Head of Global Rare Diseases. He replaces Gary Crocker, Chairman and Interim President and CEO, who guided the Company during the recent restructuring process and search for a permanent CEO and will remain Chairman of the Board.

MannKind Corporation (MNKD) recently recorded -4.25 percent change and currently at $0.54 is 31.98 percent away from its 52-week low and down -75.84 percent versus its peak. It has a past 5-day performance of -15.76 percent and trades at an average volume of 5.54M shares. The stock has a 1-month performance of -17.78 percent and is -15.01 percent year-to-date as of the recent close. There were about 498.94M shares outstanding which made its market cap $269.98M. The share price is currently -17.65 percent versus its SMA20, -15.12 percent versus its SMA50, and -34.44 percent versus its SMA200.

Feb. 01, 2017 MannKind Corporation (MNKD), a fully integrated biopharmaceutical company focusing on the discovery and development of therapeutic products for patients with diseases such as diabetes, announced the launch of a new Titration Pack containing 60 4 unit cartridges, 60 8 unit cartridges and 60 12 unit cartridges of Afrezza (insulin human) Inhalation Powder.

This new package is intended to simplify physician prescribing of Afrezza and allow patients greater dose flexibility in managing their diabetes, while potentially reducing the cost burden of multiple copays.

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More Volatility Ahead for Biotechnology Sector – Wall Street Journal (blog)

More Volatility Ahead for Biotechnology Sector
Wall Street Journal (blog)
After underperforming the S&P 500 over the past six months, the biotechnology sector is poised for more volatility ahead. The group drew plenty of attention on the campaign trail as both and Democratic candidate criticized the high prices for drugs ...

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More Volatility Ahead for Biotechnology Sector - Wall Street Journal (blog)

Anatomy of a comeback: How the Patriots pulled off a historic victory – The Boston Globe


The Boston Globe
Anatomy of a comeback: How the Patriots pulled off a historic victory
The Boston Globe
No team in Super Bowl history had overcome a deficit greater than 10 points, let alone the mountainous 25-point deficit the Patriots faced in Super Bowl LI when they fell behind the Falcons, 28-3, in the third quarter on Sunday in Houston. But on their ...

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Anatomy of a cloud project cost overrun – CIO

I recently conducted an informal survey of some cloud integration companies and found something deeply troubling. Aside from cookie-cutter or formulaic quick-start projects, more than 70 percent of cloud consulting engagements involving new customers resulted in either a 10 percent cost overrun or a change-order. The bigger the project, the more likely the overrun.

You can blame it on stupid consultants or bad estimation or nutty customers or sunspot activity, but blame does no good. Something is going wrong here, and its causing a lot of heartburn for customers and vendors alike.

In an earlier article on trends making the cloud consulting market treacherous, I mentioned that a root cause of any cloud overrun is mis-set expectations: customers believing that meeting their requirements will be simpler than it is and that it should cost less than it will. However significant that observation may be, its not particularly actionable. So lets take the next step to understand the driving specifics, and what steps we can take.

[ How to compare cloud costs between Amazon, Microsoft and Google ]

In most cloud projects, several areas are nicely contained and are unlikely to cause significant cost surprises. If setting up a function is merely a matter of system configuration, there cant be that many hours of mouse-driving involved.

We should be so lucky!

Here are the project areas where we see cost surprises on a regular basis:

This twin-headed beast can involve some very serious surprises, as its impossible to detect many of the issues until youre in the middle of draining the swamp. The cost issues scale both with the amount of data and the number of data sources.

Even if the data looks superficially clean, there may be non-printing characters, format problems, improper values, overloaded semantics and object-model ambiguities that make for a messy migration or integration. If an ongoing integration is needed, you may not realize early on that the point-to-point adaptor you originally bid needs to be replaced with a full-blown middleware system.

Solution strategy: Do a real cost-benefit analysis of the amount of data to be migrated and the number of sources to be integrated, and develop a cost model that reflects reality. Start on the migration/integration/validation tasks at the outset of the project, so the surprises come early. Expect that migration and integration can represent the single largest part of your project.

Clients often stipulate no code, out of the box functionality only as part of their project definition, and on day two of the project discover requirements that cannot be satisfied any other way. Unfortunately, too many consultants are code-happy, so they willingly nudge the client toward custom-code land. And the rich coding environment of the Salesforce.com (SFDC) platform makes it tempting for both user interface and business logic.

The problem, of course, will be developer productivity and code maintenance costs. Expect custom coding a feature to be at least an order of magnitude more expensive than configuring the standard functionality.

[ Essential CRM software features: A savvy buyer's guide ]

Solution strategy: To the degree possible, use standard system features and off-the-shelf plug-in products to meet requirements. Bend requirements to fit whats available. Push coding out of the initial delivery if possible, so coders are working on a stable platform. For items that must be built, push to streamline processes and business rules that can cause combinatorial explosions (e.g., the security model, order configurations, distribution/partner networks).

The original SFDC reporting engine strikes a nice balance between power and ease of use, but it gives spreadsheet-quality output. If you want really clever and beautiful reports, it wont take long before you run into a wall.

SFDCs Wave reporting system is both more powerful and prettier, but really leveraging its power means writing query code. For even fancier stuff with nice formatting, multi-page layouts, and automatic office-document generation third-party add-ons are needed.

But as I noted in a previous article on design work in CRM projects, if its got to be pretty, its going to be pretty expensive both to set up in the first place, and to evolve over time with your needs.

Solution strategy: Thoroughly understand and specify every variant including formats and user-specific tweaks of every single report you will need prior to putting the system out to bid. Its best to discover that you actually require 100+ reports, not the ten you thought. If you have a working report (e.g., from Access or Crystal) that you need the system to emulate, provide the vendor with a sample set of input data and the reports output, with annotations regarding format and exception conditions.

This means you, project leaders and executive champions! Things you do will contribute directly to overruns. As I discussed in an article on agile project management, distance and delay are the enemies of efficient and economical projects.

But I need to add some new Ds that are even more deadly: dithering and (unending) discovery. The first of these, dithering (a.k.a. indecisiveness) is bad enough, as it causes delay and erratic direction, which leads directly to rework. But the second, whose hallmarks are discovering that (1) the requirements werent really known up front, (2) your assumptions about how things need to work were wrong, and (3) your assumptions about how the new system features will work were wrong, is the root cause of scope creep. I cant tell you how many large projects discovered more than half of the costly requirements after formal discovery was completed.

Solution strategy: Make the discovery phase longer, and when its complete have a signoff sheet for a strict feature and data freeze. Make the project team as small and tight as it can be, and do not hire more than one consulting company (to reduce finger-pointing). Work to constantly improve trust among the team members. Kick people off the team who blame. Keep executives and bean counters as far away from the project as you can, and limit big review meetings. Focus everyones attention on business value rather than abstract or arbitrary metrics and project dashboards.

Im currently reading the book Being Wrong Adventures in the Margin of Error after having finished Wrong! Why Experts Keep Failing Us. So maybe Im a little jaded, but it sure looks to me like cost overruns are the result of bad assumptions, fragmentary information, incomplete requirements and low trust.

Interestingly, overruns are much less common for follow-on projects, where both sides have put the time in to develop good assumptions, a solid understanding of the real requirements and a trust relationship. So for initial projects, we clients and consultants have to stop the pretend-certainty about our projects.

The truth is we dont really know, and were not willing to spend the time and money to get sufficiently knowledgeable about, all the niggling details of a new project. We run off and get a budget without knowing what the project will really entail. And then we discover too many plot complications after weve reached the halfway mark in the project. For those hoping that hybrid agile techniques will solve the problem, I havent seen much help there.

In contrast, the real agile approach admits we dont know, and simply scopes the project deliverables dynamically to fit within the budget and schedule. The team discovers as they go, prioritizes as they go and focuses on maximizing business value instead of fixed (and possibly random) criteria. When done right, agile makes the bean counters happy (they can claim on time, on budget) and gets the most important stuff out to the users as soon as its done.

>> Agile project management: A beginner's guide <<

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Anatomy of a cloud project cost overrun - CIO

Professional Idiot: an Anatomy – PoliticalCritique.org

The inauguration of President Donald Trump revealed that the USA has more in common with the Czech Republic than anyone (presumably, Americans least of all) had hoped for.

President Trumps inauguration ceremony was a flop, at least within the parameters of the universe most of us live in. A universe, it turns out, not shared by Trump and his Press Secretary Sean Spicer. America is getting its first glimpse into the wonderful world of alternative facts, coming from the highest level and it honestly seems a bit shocked. But worry not dear, poor America: you are not the first nor the last. We have been there. We can share survival tips.

The Antichrists Lesson

For starters, there are historical precedents. When the then-President of the Czech Republic Vclav Klaus decided to employ known conspiracy theorist Petr Hjek, most famous for denying evolution, claiming that 9/11 was an inside job, and accusing the late Havel of having been a servant of Satan, he left more than a few heads scratching. Hjek, however, possessed a very useful ability: should it ever become necessary to draw the medias attention, he could always give an interview and bleat something about the Antichrist among us. And then shock and awe would follow.

It was not that what he claimed was particularly interesting or original; the trick was doing it from a position of authority.

This man worked directly for the president and because of that, when he spouted his drivel, the media listened because they simply could not afford to ignore him, especially with the appeal of pure, unadulterated bullshit being so high to audiences. Remove the authority, however, and you get just another conspiracy nut job with a blog. Which, coincidentally, is exactly what became of Hjek.

Now, it seems President Trump possesses a pet lunatic of his own in the person of his Director of Social Media, Dan Scavino. Hoaxes, conspiracy theories, smear campaigns, he has shared it all. The biggest challenge he has faced was to defend his lord and master after Trump retweeted an image from a white supremacist message board. Trumps campaign placed heavy emphasis on social media and there was no indication this would stop once he came in power so it will be quite a surprise if we do not hear more of the talented Mr. Scavino in the near future, and quite possibly in a newfound capacity as a sacrificial lamb. The thing about crackpots is that there are always more where they came from.

There is a lesson and a warning in this comparison: people in power always like having an idiot around and being near that power entitles said idiot to inflict his views on the country. So, dear America, you should prepare for a new onslaught of flashy nonsense.

Going Professional

The most obvious analogy, however, is that between the current presidents of the Czech Republic and the United States. Both President Zeman and President Trump are populists who declare strong pro-Russian views, both love the use of fear mongering and xenophobia to garner popularity and both possess a relationship with facts that can be described as tenuous at best. They also both employ PR specialists whose job descriptions include publicly ignoring realty.

In spite of rather overwhelming photographic evidence to the contrary, Sean Spicer claims President Trumps inauguration gathered the biggest crowd ever. It is a public, shameless lie delivered from a position of authority. It is, also, something that the Czech Republic happens to have experience with, especially given the results of last Novembers presidential vote gathering tour (above: the official version; below: police camera at the other end of the square). And it is an extremely efficient means of dealing with the pesky media.

Lenin is said to have coined the term useful idiot and a tame conspiracy theorist works very well in that role. Presidents Trump and Zeman, however, took this a step further.

What we have in Spicer and Ovek is a logical evolution: the professional idiot.

Here is how it works: the president either slips up or unabashedly tells a lie about, say, a historical article that totally exists or the oh-so-huge Chinese investments in the Czech Republic. The Media points it out and in steps Ovek, either insisting on the lie, producing an alternative and even more outrageous statement or attacking the media in extremely petty ways. Standard PR practice where the truth does not enter the process at any point, right? But there is a difference: professional idiocy results in the unprecedented presence of Zeman in the media the Czech Republic is not a presidential system, the man is there literally just to ruin our reputation abroad. Yet his every (mis)step is religiously followed by the media and he uses it to the maximum to voice populist views quite likely to help him in the next election after all, terror is coming!

Jester to Speaker

The professional idiot strategy works simultaneously as an attention grab and misdirection. Consider President Trumps inauguration mess. Almost immediately afterward, Trump followed it up with a lie about the popular election presumably the same invisible crowd present at his inauguration that happened to have voted invisibly by casting invisible ballots into invisible boxes. Americas stealth plane technology has apparently entered the public domain.

Meanwhile, Spicer proves that he is a real pro in the idiot biz by attacking the media and pitching another shovelful of bullshit towards the pile by stating that the inauguration had the largest audience ever, and by the way, why are we still talking about this and can we get to running that pipeline over Sioux sacred grounds again already?

A professional idiot possesses no qualms about ethics or taste and will most certainly not let something as trivial as facts slow him down on his way towards attention. An analogy to the time-honored institution of the court jester comes to mind, although with a rather crucial difference: while in ages past it was the jesters prerogative to talk smack in the presence of the monarch and to the monarch, it seems a supremely stupid suggestion to have the jester speak for the monarch.

To Wage War on Reality

There is another, altogether more sinister turn to this. A professional idiots job (which, at least in some cases, appears to be a hobby as well) is a symptom of society. Post-truth is the buzzword that immediately comes to mind, but there is more. A systematic denial of reality is also a tool of totalitarian propaganda: recall that the crowning achievement of indoctrination is doublethink. This is something professional idiots seem to radiate effortlessly, especially when flocking around politicians with dictatorial tendencies.

It is entirely possible that Spicer cheered along with the invisible crowd at the inauguration, that Zeman and Ovek read the article on the bottom left of the page and that Trump has evidence that the popular vote was tampered with by millions of illegal voters. We all do this to some extent mentally editing experiences and memories to fit our own world-view. It only becomes problematic once the person in question is unaware of the factand in possession of power.

And so we get alternative facts instead of lies, different recollections instead of mistakes and quickly evolving opinions instead of contradictions. It is a sign of the times. Perfectly natural. Nothing wrong about this sign of the times, we got the best times in the world.

Do not worry, America. You will be alternatively fine.

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Professional Idiot: an Anatomy - PoliticalCritique.org

Anatomy of Ahmedabad’s road accidents – Times of India

AHMEDABAD: The city reports six deaths per week on the road. Victims vary from senior citizens crossing a road to youths high on liquor behind wheels. Out of over 3,000 road accidents reported with EMRI 108 ambulances, majority take place in the city periphery on roads such as SG Road and SP Ring Road. Why do these accidents take place, and how to reduce fatalities?

A report by JP Research India, titled 'Ahmedabad and Gandhinagar Road Accident Study' analyzes 211 accidents that took place between February 2004 and February 2015 on the 31-km stretch of SG Road, 27 km of SP Ring Road, 13.5 km of NH8 and 27 km of state highways passing near or through Ahmedabad and Gandhinagar.

The study is part of a national scientific database called "Road Accident Sampling System - India" (RASSI). It is submitted to the state transport commissioner by the agency. According to the research, cars and two-wheelers posed highest risk of accidents among road users. Both segments were found involved in 56% (28% each) of total road accidents. Moreover, two-wheelers were most affected - having been involved in 53% of fatal accidents and 47% of serious accidents. The study mentions that only 22% of the total road accidents get reported to police. Moreover, out of 211 accidents, 34% were serious accidents, 8% fatal and 48% minor. In 8% cases, there were no injuries whereas in 2% cases there is unknown outcome.

Link:
Anatomy of Ahmedabad's road accidents - Times of India