Powerful new tool for research and drug development

ScienceDaily (June 4, 2012) A University of Saskatchewan research team led by Tony Kusalik and Scott Napper have harnessed bioinformatics and molecular biology to create powerful software that promises to become a "must have" tool in drug development research labs the world over.

The software is used to analyze kinases -- a type of enzyme involved in virtually every cellular function, from energy use and reproduction to modifying gene expression. Licensing of the patented technology is currently underway, and a demonstration of its effectiveness recently appeared in the journal Science Signalling.

"This is a premiere example of what can be achieved through interdisciplinary and collaborative research," says Kusalik, a professor in the computer science department.

Kinases are often involved in cellular functions that go awry, such as when pathogens such viruses or bacteria "hijack" a cell's functions for their own purposes. Pathogens also have kinases of their own.

"Kinases have a central role in controlling cellular processes and are associated with many diseases. They're logical points for understanding biology and represent important treatment targets," says Napper, an associate professor of biochemistry with the U of S and senior scientist at the Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-InterVac).

The standard lab tool in kinase research is the microarray, which allows researchers to analyze many different kinases within a sample simultaneously. A microarray looks like a standard microscope slide with rows of spots, each spot representing a different molecular test.

"With older methods, it was like having a little flashlight in a cave -- you can see, but it doesn't tell you all that is there," Napper says. "These arrays give you the whole picture -- but you end up with absolutely mountains of data."

The problem for Napper and fellow VIDO-InterVac senior scientist Philip Griebel was that the mountains of data were making no sense. Griebel is also a faculty member with the U of S School of Public Health.

"They knew there were problems with the methodology they were following, because the results 'weren't working out,' but they didn't have sufficient expertise in bioinformatics to come up with an alternate method. That's where we came in," Kusalik says.

Kusalik is an expert in bioinformatics, which is the application of computers and information technology to biology and medicine. One well-known application of bioinformatics is DNA sequencing, including the Human Genome Project.

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Powerful new tool for research and drug development

'Synthetic Biology for the Next Generation'

Public release date: 4-Jun-2012 [ | E-mail | Share ]

Contact: Molly Galvin news@nas.edu 202-334-2138 National Academy of Sciences

At this National Academy of Sciences and National Academy of Engineering symposium, stakeholders will examine the tools, platforms, and infrastructure needed for continued advances in synthetic biology; political and social strategies to pursue these advances; and research applications in key areas. The symposium is the final of a three-part series organized in conjunction with the Royal Society, Royal Academy of Engineering, and Chinese Academies of Sciences and Engineering. It will take place on June 12 and 13 from 8 a.m. to 5:30 p.m. EDT in the auditorium of the National Academy of Sciences building, 2101 Constitution Ave., N.W.

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Those who cannot attend may watch a live webcast at http://www.national-academies.org. For a complete agenda or to register, visit http://www.nationalacademies.org/stl.

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

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'Synthetic Biology for the Next Generation'

Lando & Anastasi, LLP Expands Biotechnology/Pharmaceutical and Electrical/Computer Patent Teams

CAMBRIDGE, Mass.--(BUSINESS WIRE)--

Lando and Anastasi, LLP (L&A) today announced that Julie Gottselig, Dominic Yee, and Austin Kim have joined the firm.

The Cambridge-based intellectual property law firm, one of the largest IP firms in New England, continues its steady growth in response to strong client demand for high quality and responsive intellectual property legal services. The L&A biotechnology and pharmaceutical practice will expand with the addition of Julie Gottselig and Dominic Yee; and Austin Kim will join the firms electrical and computer science practice.

Julie Gottselig is an Associate at L&A. She focuses her practice on patent prosecution and counseling in the areas of biotechnology, pharmaceuticals, molecular biology, biochemistry, medical devices, and related fields. Prior to joining L&A, she was an Associate at McCarter & English, LLP in Boston. Julie is registered to practice before the United States Patent and Trademark Office.

Julie graduated from New England School of Law, summa cum laude, where she was the valedictorian of her class and recipient of the Dean Arthur W. MacLean Award for academic excellence. She received a Ph.D. in Neuroscience from the University of Iowa; she completed her post-doctoral fellowship at Harvard Medical School and Brigham & Womens Hospital; and she was a post-doctoral researcher at the Institute of Pharmacology & Toxicology, University of Zurich. Julie received her B.A. in Psychology from Colorado College. Prior to entering intellectual property law, Julie authored numerous peer-reviewed scientific research articles published in leading journals, and has received several research awards, including postdoctoral fellowship awards from the National Institute of Mental Health and the National Heart, Lung, and Blood Institute.

Dominic Yee is a Technology Specialist at L&A, and focuses his practice on patent prosecution, diligence and counseling in the areas of areas of biotechnology, pharmaceuticals, and chemistry.

Dominic received a Ph.D. in Chemistry from Columbia University, and he completed his post-doctoral fellowship with Nobel laureate Roger Tsien at the Howard Hughes Medical Institute at University of California San Diego (UCSD). Dominic received his B.S. in Chemistry and Biochemistry, magna cum laude, from UCSD. He attends Suffolk University Law School. Prior to entering intellectual property law, Dominic was a Scientist at Vertex Pharmaceuticals, where he worked on solid dosage form development and drug delivery technologies.

We are excited that Julie and Dominic have joined the life sciences team at L&A, and welcome the technological expertise they bring to both the biological and chemical aspects of our practice, commented Louis Myers, a Partner at the firm.

Austin Kim is an Associate at L&A. He focuses his practice on patent prosecution in the areas of computer science, electrical engineering, mechanical engineering, and medical devices. Prior to joining L&A, he was an Associate at Fish & Richardson in Boston. Austin is registered to practice before the United States Patent and Trademark Office.

Austin graduated from Boston College Law School. He received an M.Eng. and S.B. in Electrical Engineering and Computer Science from the Massachusetts Institute of Technology.

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Lando & Anastasi, LLP Expands Biotechnology/Pharmaceutical and Electrical/Computer Patent Teams

Omega XL Announces New Study: High Sugar Diet Sabotages Memory, Omega-3’s Can Offset Damage

FORT LAUDERDALE, Fla.--(BUSINESS WIRE)--

According to a new study published in the Journal of Physiology (http://jp.physoc.org/content/early/2012/03/31/jphysiol.2012.230078.abstract), the American diet is laden with staggering amounts of sugar and high fructose corn syrup. Between soft drinks, candies, desserts, and processed foods the average Americans consumption of high fructose corn syrup amounts to roughly 35 pounds in a year, with cane sugar totaling another 47 pounds. Volumes of published research has shown a direct connection between these sugars and metabolic conditions such as obesity, elevated triglycerides and diabetes, however there is no data on such high sugar intake and its impact on mental health.

Over a five-day period, researchers Fernando Gomez-Pinilla and Rahul Agrawal, from the University of California at Los Angeles, trained two groups of rats, twice a day, to navigate a maze. Then, for a subsequent six-week period, the rats were fed a fructose solution in place of drinking water, while the second group was also given the omega-3 fatty acid docosahexaenoic acid (DHA) and flaxseed oil (a rich source of omega-3 alpha-linolenic acid, which mammals convert less efficiently to DHA). Considering brain tissue is roughly 40% DHA, researchers observed that the chemical connections between brain cells effecting learning and memory might be protected from the perceived dumbing effects of fructose by the omega-3 fatty acids.

After six weeks, the researchers tested the rats in their ability to recall landmarks that enabled them to navigate the maze and escape. The omega-3 fed group was able to recall the exit route and escape the maze faster than the group receiving only sugar. The brains of the rats were later examined. The rats fed only fructose had brains exhibiting signs of declined synaptic activity, as well as signs of insulin resistance, which regulates synaptic function and controls blood sugar. The scientists concluded that diets high in sugar and high fructose corn syrup disrupt memory and learning, however omega-3 fatty acids can help, at least partly, offset the disruption.

According to researcher Gomez-Pinilla, one gram per day of Omega-3 fatty acids can protect the brain from fructoses dumbing effects. Its like saving money in the bank, he said in a statement. You want to build a reserve for your brain to tap when it requires extra fuel to fight off future diseases.

Omega XL is a bestselling super Omega 3 supplement that contains the patented stabilized marine lipid extract PCSO-524 derived only from the New Zealand green-lipped mussel with 30 healthy fatty acids including DHA and EPA. Omega XL, manufactured exclusively by Great HealthWorks Inc., is the most widely available omega-3 fish oil supplement containing the potent PCSO-524 marine lipid extract. To find more information about Omega XL and PCSO-524 visit http://www.OmegaXL.com.

Source: Journal of Physiology

Metabolic Syndrome in the brain: Deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signaling and cognition

http://jp.physoc.org/content/early/2012/03/31/jphysiol.2012.230078.abstract

Fernando Gomez-Pinilla and Rahul Agrawal

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Omega XL Announces New Study: High Sugar Diet Sabotages Memory, Omega-3’s Can Offset Damage

Nutrition talks with patients: option or obligation?

Ethics Forum. Posted June 4, 2012.

Nutrition is a major factor in an increasingly complex equation that determines overweight and obesity in the United States. Are physicians prepared to help patients improve this aspect of obesity prevention?

Reply:

Being overweight or obese increases the risk for many chronic health conditions. Even in the absence of excess weight, unhealthy food choices and physical inactivity are associated with major causes of morbidity and mortality, including cardiovascular disease, hypertension, type 2 diabetes, osteoporosis and some types of cancer. The high prevalence of these diseases begs that counseling in nutrition be offered as a part of good medical care. In many cases, such counseling becomes a necessity.

Recently, the Centers for Medicare & Medicaid Services announced that Medicare will pay for obesity counseling if it is coordinated by a primary care physician. CMS determined that the evidence is adequate to conclude that intensive behavioral therapyfor obesity, defined as a body mass index 30 kg/m2, is reasonable and necessary for the prevention or early detection of illness or disability and is appropriate for individuals entitled to benefits under Part A or enrolled under Part B and is recommended with a grade of A or B by the [U.S. Preventive Services Task Force].

More people seek medical care services from a primary care physician than from any other source. Hence, the primary care physician should be the one to initiate discussions about nutrition. Perhaps the best time to do it is when explaining the management of the many chronic conditions that diet can affect, such as hypertension, hyperlipidemia and overweight.

Some points that physicians should share with patients:

The U.S. Dept. of Health and Human Services has developed evidence-based guidelines for nutrition and physical activity to promote health and reduce chronic disease risk. The recommendations of the Dietary Guidelines for Americans are exemplified by the Dietary Approach to Stop Hypertension (DASH) eating plan, which, in clinical trials, demonstrated health benefits, including lowering blood pressure, improving blood lipids and reducing cardiovascular disease risk and mortality. The Physical Activity Guidelines for Americans also contain recommendations for reducing chronic disease risk and managing weight.

The U.S. Preventive Services Task Force has determined that intensive behavioral dietary counseling is beneficial for adult patients with certain risk factors for cardiovascular disease or other diet-related chronic conditions (a grade B recommendation), but also that there is insufficient evidence to support routine counseling in unselected patients (grade I statement insufficient evidence available). A grade B recommendation also was given to screening adults for obesity and offering intensive counseling and behavioral interventions for obese adults. An I statement was given for counseling and screening overweight adults.

Whether physicians should be the ones to provide intensive counseling, however, is a little less clear. Because nutrition education is severely limited in most medical schools, the primary care physician may not be the person most qualified for the task. On average, medical students receive less than 20 contact hours of nutrition instruction during their medical school training. Hence, many do not feel equipped to give sound nutritional advice. In a recent survey of primarycare physicians, 78% said they had no prior training on weight-related issues; and 72% of those said no one in their office had weight-loss training.

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Nutrition talks with patients: option or obligation?

Volunteer, 85, awarded Governor's Medallion

If longevity and dependability are the stuff of an effective volunteer, then James Sifford certainly has the right stuff.

This fall, he'll have completed his 22nd year of service to the Second Harvest Food Bank of Northwest North Carolina. The work which Sifford, 85, has done most Tuesday afternoons in retirement involves critical recordkeeping tasks in distribution. The food bank distributes food to 400 partner-agency programs.

This past April, Gov. Bev Perdue recognized Sifford as one of the state's top volunteers, awarding him a Governor's Medallion in a ceremony coordinated by the N.C. Commission on Volunteerism and Community Service.

"It's an honor to have won it," Sifford said recently. He added that he enjoys volunteering at the food bank.

"I feel like it's a group thing where everybody's on the same page," he said. "Everybody's working for the same goal. Most people feel it's a real needed thing."

Clyde Fitzgerald, the executive director of the food bank, said his organization has been blessed and privileged to have Sifford as a volunteer.

Sifford "knows the roles that he has to follow and the job he does for us in the distribution area," Fitzgerald said. "We count on that. I don't know what we'd do without Jim."

Fitzgerald said Sifford's role "is to take several days' worth of paperwork and properly input it to the computer," so that partner agencies know "how many pounds of food they've got and how much money they've saved by getting it here." The agencies then supply this information to funders.

So far in 2012, Fitzgerald said, the food bank saved its partner agencies "over $35 million in food-acquisition costs because they got it from us."

"The way we communicate that to them is on each order and on each shopping trip," Fitzgerald said. "Jim is critical to our ability to do that."

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Volunteer, 85, awarded Governor's Medallion

Inventor of plumbing on a chip wins $500,000 prize

1 hr.

John Roach

Stephen Quake, a prolific inventor whose application of physics to biology has led to breakthroughs in drug discovery, genome analysis and personalized medicine, has won the $500,000 Lemelson-MIT Prize, a prestigious award for outstanding innovators.

A big part of physics is trying to figure out how to measure things, Quake, who is a professor of bioengineering and applied physics at Stanford University, told me. And so I get interested in a biological problem [and] figure out a way to measure it.

Among his many inventions is the biological equivalent of the integrated circuit, so-called microfluidic large scale integration.

I got interested in trying to automate biology the way the integrated circuit automated computation, he said. And so you need a chip that, instead of having wires and transistors on it, has pipes and valves and pumps and things.

It is little miniaturized plumbing. Its got up to tens of thousands of mechanical valves on a chip, and all kinds of plumbers nightmares.

Quake co-founded Fluidigm to commercialize the technology in 1999. The company generated $10.8 million in sales in the first quarter of 2012, Reuters noted.

Applications of the technology are myriad, including Quakes own work on single-cell genomics. Others have used it to help determine the structure of proteins, including for the Ebola virus and H5N1 influenza virus, for example.

Another Quake innovation is a non-invasive pre-natal test for Down syndrome which is based on analysis of blood taken from a mothers arm, which includes fetal DNA.

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Inventor of plumbing on a chip wins $500,000 prize

Vandenberg is smarter than the average bear

James Vandenberg is a starting quarterback in the Big Ten. He is studying human physiology at the University of Iowa. He is taking summer school classes. And this season he is adjusting to a new offensive system with new coordinator Greg Davis.

The senior deserves a chance to relax.

Vandenberg, a Keokuk High School graduate, recently got away from it all, and brought back a monstrous reminder of his trip.

Vandenberg went on a hunting trip to northern Saskatchewan, a graduation trip for his sister, Olivia, who graduated from Iowa in May.

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"It was a fun trip," said Toby Vandenberg. "We went five-for-five. James got the biggest."

Hunting runs in the Vandenberg's blood.

James Vandenberg's great grandfather, Lewis James, killed a bear in the 1940s. He became famous for the feat as he was asked to speak about it by organizations throughout the area, earning the nickname 'Bear.' The elk mounted at the Elks Club in Burlington was killed by "Bear" Vandenberg, Toby said.

James and Olivia are not even the first of their siblings to come home with a bear. Brother Elliott killed a bear in another part of Saskatchewan when he was in middle school.

Like his great grandfather after whom he was named - Vandenberg's full name is James Lewis - Vandenberg has earned some notoriety for his hunting prowess.

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Vandenberg is smarter than the average bear

Austin's source for local news

Published 4:34pm Saturday, June 2, 2012

Are nutrition and health related? Is healthy eating important? Of course.

Like a finely-tuned racing car, your body needs the right fuel (food) and regular maintenance (exercise, lifestyle and mental attitude) to achieve its true health potential. Nothing is more important than healthy eating. Put in the wrong fuel or let it go without regular use and theres no way it can deliver its full power and performance. Without healthy eating, your bodys engine will cough, splutter and eventually stall.

The importance of good nutrition to achieve optimal health is unquestionable. The importance of good nutrition is central to maintain good health in a dilapidated environment, fight off disease, correct imbalances in the body and provide energy and enthusiasm for life. Optimum health is linked to the importance of good nutrition.

But, the point is that the importance of good nutrition is linked to ones capability to get the proper nutrients from food.

Nowadays, industrial food marketed in the food chain are filled with additives which affect the quality of food. In order to value the importance of good nutrition, natural supplements like vitamins and minerals have to be added to the diet.

Each year, the average American eats 12 pounds of food additives and a gallon of pesticides, not to mention all the air-born pollutants that are inhaled. Its no wonder our bodies are overworked, overburdened, and no longer able to adequately eliminate all these foreign substances. Diet-related diseases include, but are not limited to, coronary heart disease, hypertension, stroke, diabetes, various cancers and osteoporosis. These diseases take the lives of millions of people each year and cost billions of dollars in health care.

On Wednesday, Tianna Bechly, RD LD, Clinical Dietitian for Mayo Clinic Health System-Austin will be with us at 1 p.m. to discuss the New myPlate Diagram, Healthy Eating Tips, Healthy Snack Ideas, Easy Exercise Ideas, and then finish with a general Q&A session.

To sign up for this informative class please call or stop by the front desk at the senior center everyone is welcome. Call 433-2370 ext. 3.

Monday: Blood pressure, 9 a.m.; cards (Pinochle, Duplicate Bridge), 12:30 p.m.; Exercise with Evie, 1 p.m.; Zumba, 5:30 p.m.; Zumba, 7 p.m.

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Austin's source for local news

Why do Israelis live so long?

Israelis love to gripe about the country. Israelis think life here is much harder than in other Western countries. It turns out that Israelis also have a lot of time to devote to their grousing: life here may be difficult, but Israelis live long lives.

At 81.5, Israel has the sixth highest life expectancy in the world. This is mainly because of the men, statistically speaking. Israeli men can expect to live 79.6 years, on average, the third highest in the world, bested only by men in Switzerland (79.9) and Iceland (79.7).

How do Israelis enjoy such longevity?

Part of the answer lies simply in money. Citizens of OECD member countries are not only the richest: they boast the highest life expectancy. This is little surprise: it is well recognized that money can buy health services, which in turn prolongs life.

Research carried out in numerous countries has shown that three factors combine to prolong longevity: a good health system, good nutrition and a healthy lifestyle. All three depend on a countrys affluence and its ability to invest in improving health services, in education towards healthy living, and in its ability to provide a wide variety of nutritious food.

Israel is one of the more developed countries in the world, and a member of the OECD. It could therefore be expected to have high life expectancy.

Specifically, its health services are apparently still one of the better ones on the globe. Despite growing concerns about recent deterioration, the health system here is quite advanced and fairly egalitarian and accessible.

An additional major contributor to longevity is the local Mediterranean diet, with its abundance of fruit, vegetables and olive oil, as well as a preference for poultry over red meat. The climate is also thought to be salubrious, with moderate temperatures and long daylight hours on average, all contributing to reducing stress and seasonal depression.

However, other Mediterranean countries have similar dietary habits and climate, without boasting particularly long life-spans. Greece, for example, lags far behind Israel in its citizens life expectancy.

The argument by which the advanced egalitarian health system is conducive to a long life is also problematic. Scandinavian countries have no less of an advanced and progressive health system, yet Israelis tend to live longer.

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Why do Israelis live so long?

Around Iowa State University: June 3

ISU proposes department name

Pending approval by the Iowa Board of Regents, Iowa State Universitys Department of Biochemistry, Biophysics and Molecular Biology will be named in honor of the Roy J. Carver Charitable Trust, in recognition of gifts and commitments to the department totaling more than $12.3 million.

This support includes a $7.5 million commitment announced Thursday to support strategic research initiatives in biomolecular structure.

Also known as structural biology, this scientific field seeks to better understand basic biomolecular function, which can hold the key to unlocking important new discoveries in wide-ranging areas important to human, plant and animal life.

With the regents approval, the new name will be the Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology.

ISU grads give scholarships

Benches, plaques, art, fountains these are typical class gifts. Tangible things you can sit on, gaze upon, drink from.

Cognizant of the growing financial pressures on college students, ISUs class of 2012 opted to leave something different to the alma mater. The class set up an endowment that will fund scholarships for upperclassmen.

Thus far, more than 600 recent graduates have pledged $45,400 to the scholarship fund.

Thats an average of $74 per graduate, said Sarah Johnson, a program manager in the ISU Foundation. And we expect the endowment to grow in the next couple of weeks as student fundraisers finish making contacts with the graduating seniors.

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Around Iowa State University: June 3

Check Out CGL’s Exome Sequencing Test

6a00e009846ac188330168eb80fe20970c-320wiAt the ASCO Annual Meeting in Chicago (June 1 to June 5), the Cancer Genetics Laboratory and the Whole Genome Laboratory at Baylor College of Medicine (BCM) will officially announce the clinical implementation of the Cancer Exome Sequencing test. This test is the result of a collaboration between genomic scientists, clinical laboratory scientists, geneticists and oncologists at BCM to provide reliable cancer genome-wide analyses that are carefully annotated and interpreted for clinical significance.

The Cancer Exome Sequencing test follows on the successful 2011 launch of germline exome sequencing for the evaluation of inherited disorders. The Cancer Exome Sequencing test focuses on somatically acquired genetic alterations in tumors and applies the power of next-generation sequencing technology to cancer genetics in a CAP/CLIA-approved setting with clinical interpretation of sequence information. This test is ordered by a physician and may be used when a patient’s oncology management would benefit from identifying genetic changes in the tumor that predict sensitivity or resistance to a variety of therapeutic regimens.

Cancer Exome Sequencing is poised to change the current paradigm of genetic testing for cancer patients by focusing on whole exome analysis of a patient’s tumor. The term exome refers to the portion of the human genome that contains the DNA sequence that directs protein synthesis. These functionally important regions of DNA are referred to as exons. The 22,000 known genes are comprised of approximately 180,000 exons and represent about 3% of the genome. Most errors in DNA sequence that lead to altered protein function in tumors are located in the exons, therefore, exome sequencing is an efficient method for tumor DNA sequence analysis to uncover genetic causes for tumor behavior.

The principle of the test is to sequence nucleotide by nucleotide, the human exome of normal tissue (generally blood) and a sample of tumor tissue to a depth of coverage necessary to determine sequence variations that are unique to the tumor (somatic mutations) with high sensitivity. Point mutations, insertions and deletions of the exome are potentially discoverable and could be considered important for cancer management depending on the defect and available evidence. These sequence variations are then categorized based on their role in defining a specific tumor property or tumor sensitivity to established and novel therapeutic approaches. This test will report all somatic mutations identified in the tumor genome and classifies them according to clinical utility based on careful evaluation of functional and clinical evidence in the medical/scientific literature and the availability of agents targeted to a specific gene or pathway. This test also reports the presence of inherited (germline) genetic variations in selected genes known to increase the risk for cancer (e.g. APC, TP53, and others).

Please join Baylor College of Medicine at the ASCO Annual Meeting (Booth #22082) for additional information on the Cancer Exome Sequencing test and to meet with BCM Medical Directors to further discuss this test and other services.

 

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Smart Imaging Technologies adds archiving and storage of digital slides in Aperio SVS format

Logo_sitWith the latest version of Simagis Live server, administrators have an option to archive and store digital slides in a version of TIFF format also known as BigTiff or Aperio SVS file format. 

Advantage of this slide format, introduced to Digital Pathology by Aperio, is that it is open and supported by the latest version of public Libtiff library. It is also supported by free desktop software applications such as Aperio’s ImageScope slide viewer.

Simagis Live servers support various compression options for SVS files including both lossy JPEG compression and lossless options such as JPEG2000 or LZW that may be required by FDA in the future to preserve diagnostic image quality.

With Simagis Live servers, users already could upload, view, share and analyze digital slides from different scanners including Aperio, Hamamatsu, Mirax, Leica, Mikroscan, DigiPath, Huron and others. Now, with the option to store slides in SVS format, they get single unified digital slide archive interchangeable with other servers and desktop viewers. This feature is especially valuable for organizations that have several scanners from different vendors and need an integrated solution for viewing, sharing and analyzing digital slides.

This option is also valuable for scanner manufacturers who use Smart Imaging Technologies servers under their own brands to provide slide sharing and analysis solutions to end-users. They can assure users that slides are stored in an open format accessible by third-party software.

About Smart Imaging Technologies

Logo_im_solutionWe provide web servers and applications for viewing, sharing and analyzing whole slide images. Our servers support most digital slide formats, can be easily integrated with various scanners for a single click slide upload, and deployed on premises or on High Performance Computing Cloud.  For details about technology and solutions manufacturers and integrators may contact support@simagis.us .

End-users can learn more and sign-up for free web service at web-pathology.net.

 

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X-rays, digital pathology and iPads: The network healthcare evolution

PathCentralScreenShot-1_5-11-2012

 It is just a matter of time that pathologists too will recognize the value of wireless connectivity, coordinating care, analytical tools for diagnosis and management and closer follow up, all enabled through mobile computing and digital pathology.

Xray-ipadsAt the rate technology has changed everything else in our lives, by now we should have the equivalent of tricorders in our smartphones—instant access to our health statistics collected by sensors in our clothes and pulled into our individual health history in the cloud. We should be able to Skype our physician, text our pharmacist, and get both a blood sugar measurement and an MRI at Starbucks while waiting for a grande latte.

Except for the MRI part, all of that is doable today. Thanks to the big stick provided by the Affordable Care Act in the US, some healthcare organizations are pushing more aggressive use of network bandwidth and cloud technology:

  • Monitoring patients’ health more proactively with networked devices, ranging from wirelessly networked medicine bottle lids to worn or embedded sensors that report back on vital signs;
  • Coordinating care with the help of analytic tools in the cloud and a wealth of individual and collective patient data; and
  • Connecting physicians directly with patients over PCs or mobile devices for between-appointment follow-ups.

Those things can’t be pulled off without cloud technology, whether it’s hosted internally in a health organization’s data center or elsewhere. But ask any random sampling of physicians, technologists, and health industry observers. They’ll tell you technology isn't restraining the next big paradigm shift in health care. The bandwidth is willing.

“It’s less about the technology holding the industry back, and more about the reimbursement model for healthcare,” says Kenneth Kleinberg, senior director of research and insights at The Advisory Board Company, a global healthcare research, technology, and consulting firm. “Quality hasn't been rewarded, physicians don’t have incentives to share data, and patients are freaked out about privacy. Healthcare isn't a system—it’s a bunch of individual entities looking out for themselves. Just adding more bandwidth to a broken system doesn't work.”

Real technological change in health care requires changing the “work culture” of health organizations and people’s confidence in health IT systems, says Harry Kim, senior director of Hewlett-Packard’s healthcare group. But other complex (and heavily regulated) businesses have embraced change long ago. Citing ATMs, Kim says, “If we can trust our money to a machine, we can do it with healthcare.”

That’s why health organizations are looking outside of their industry for inspiration. “The companies bringing the biggest changes to medicine today are companies like Cisco, EMC, Apple, and Microsoft,” says Dr. Elliot Fishman, Director of Diagnostic Imaging and Body CT at Johns Hopkins Medical Center. Technology from the consumer sector (such as mobile devices and apps, cloud computing, and even gaming) is seeping into the healthcare field and being seized upon by care providers to improve the connection between physician, patient, and data.

To get an idea of how bandwidth can change medicine, we talked to people on the front lines of medical technology at two of the most well-known hospital systems in the US: Johns Hopkins and the University of Maryland Medical Center. We also caught up with technology and digital health service providers. What we got was a snapshot of organizations that are already working to transform medical care with networked technology, while trying to overcome organizational inertia to make it happen.

Driven by data

The first wave of change that healthcare organizations have dealt with (or are still dealing with) is what Kim calls the “digitization of sick care.” Nearly 80 percent of healthcare is dealing with chronic illness. To improve care for patients with chronic health problems, health providers need to be able to effectively monitor and capture the right data from them, pull it back into electronic medical records, and make it available to both patients and physicians to act upon.

The problem is that many health record systems weren't built to handle those tasks. Healthcare systems have had electronic health records for decades; the problem is the systems lack standardization. These carry with them the sorts of software and schema hangovers that plague every data integration project.

“At Hopkins, it started a long time ago with a longitudinal patient record that pulled in from all our systems,” says Stephanie L. Reel, Vice Provost of Johns Hopkins University, Vice President of Information Services at Johns Hopkins Medicine, and CIO for both the university and hospital. The system acts as a repository for information from all of the hospital systems’ various health systems.

“But in spite of the fact that I think we've done a good job over the last 25 years, we've now realized we didn't,” Reel says. The effort required to get all of the data normalized from each of the systems was “too expensive, cumbersome, and not always possible.”

So Hopkins is replacing its homegrown system with one from Epic, a hosted system with a single, patient-centric database. Reel says that when it’s implemented, the system will “give each patient control over his or her own records.” Patients finally gain complete access. Since it’s a single integrated system, all of an individual's data is there for each caregiver—their allergies, test results, medications, etc. Epic's portal can even be accessed through mobile apps for Apple iOS and Android devices.

Epic's Canto electronic medical record app for iPad.

But on top of that, the data will also be used to mine information on how well different courses of care worked for patients. This should help tailor care based on patients' own conditions and the outcomes of people with similar cases. “You can look at a population base that has benefited from treatment,” Reel said. “We can learn from our own cases, but also if done appropriately, can learn from interventions elsewhere. This gives us the opportunity to do personalized medicine—based on previous cases, we can be able to predict when patient will benefit from one type of intervention or another—or, from their genetic makeup, might be able to decide if treatment won’t help.”

BYOD medicine

Physicians aren’t waiting for their central IT departments to achieve the nirvana of centralized healthcare data. They’re finding their own ways to get access to the information they need, when they need it—pushing health providers to build Web portals and other applications that give them access to medical records anywhere. One of the most visible signs of change is the adoption of the iPad and other mobile devices by physicians.

Thanks to more reliable and more widely available wireless bandwidth, the iPad has become an essential tool for clinicians. Last October, the Department of Veterans Affairs moved to open up its network so that doctors could use their own mobile devices. While other health systems have been slow to officially adopt the iPad and other devices, John Kornak, Director of Telehealth at the University of Maryland Medical Center says, “A BYOD (bring your own device) mentality is starting to take shape among physicians, and more mobile apps are starting to find their way into use.”

Kornak says that there is a strong push from doctors to find mobile apps that make it easier and more seamless for them to connect to health data such as charts and radiology images. “Physicians are telling us if we don’t have [the apps they need], we need to have a development partner and build it ourselves. They're really urging us to not focus on what the standards are—we need to be open to any devices on market, and keep them in mind when building solutions.”

One of the most obvious applications for the high-resolution screen of the latest iPad is displaying medical imagery. By pulling up images from CT scans and MRI scans on their iPads, Hopkins’ Dr. Fishman says surgeons now use the iPad to explain procedures to patients more effectively. “Doctors can look at their cases in real time. Now my clinicians are looking at the information I generate as it’s created. They can pull down CT slices in 2 seconds. It’s very fast and interactive. They can bring the image to the bedside or in the office.”

That mobility and ease of access pays off in another way: time. “When you speak to surgeons at Hopkins,” says Fishman, “they say that they save about an hour of time each day from using the iPad. And that’s a big deal—instead of going home when their kids are asleep, they get home when their kids are awake.” Fishman says he’s been at the beach and on airplanes and has been able to look at radiology images for consults.

That power doesn’t just come from the digitization of raw information, though. It only works, Fishman says, when the networking piece becomes transparent. “The end-user experience has to be that it just happens," he says, "not typing 20 codes in for access and hoping that it works.”

Read more.

Sean Gallagher / Sean is Ars Technica's IT Editor. A former Navy officer, systems administrator, and network systems integrator with 20 years of IT journalism experience, he lives and works in Baltimore, Maryland.

 

 

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AccelPath, Inc. Letter to Shareholders

05/29/2012 | 08:35am 

Accelpath_top

AccelPath, Inc. (OTCBB: ACLP) ("AccelPath" or the "Company") issued the following Letter to Shareholders today outlining the Company's overall business strategy and operational highlights and achievements since the beginning of calendar year 2011.

The Company's overall business strategy is to expand its core business of providing a unique, viable and efficient solution for enabling digital telepathology, while capitalizing on its 3D imaging technology. The proven 3D technology has several direct applications in digital telemedicine and will continue to be developed by AccelPath. Other related and significant applications for the 3D technology, such as security and engineering, will be developed through joint ventures both domestically and internationally.

During 2011, the Company developed its core workflow technology while negotiating client and provider agreements and establishing regional business "pods." The Company's regional presence provides a basis for its eventual national footprint. A portion of this activity enabled developing the "loop" of complete automation and digital transfer of pathology information from laboratories to skilled pathologists and back to awaiting physicians. These physicians require fast, reliable pathology reports for their patients requiring immediate diagnoses and treatment of significant diseases. The Company began generating revenues towards the end of 2010.

Selected highlights and achievements include:

  • Completed base level portion of workflow IT technology. AccelPath has developed a unique and proprietary suite of HIPAA compliant software tools to enable creation, submission, and reporting of pathology cases and to provide secure online access to reports. AccelPath works with pathologists, laboratory staff and clinical office managers to design and further develop and advance the toolset. This solution is unique in its capability of handling both glass and digital slides, hence, providing an automated solution for all pathology cases. Also, the Company's technology is novel in its ability to be customized for any pathology laboratory practice or interpretation center based upon the software's modular configuration and universal interfacing with existing disparate software toolsets.
  • On-going discussions with leading slide scanner manufacturing companies to enter into strategic partnerships. AccelPath is in discussions with leading slide scanner manufacturers to provide clinics and hospitals with worksite planning, technical services including software interfaces and scanner operations, network engineering, professional pathology services and post-implementation support. Scanner deployments will allow the Company to further digitize its product offerings, allowing advancement of its strategy of providing efficient, timely, fully automated, digital pathology services using existing electronic information technologies.

AccelPath is collaborating with these scanner manufacturers to facilitate any near-term regulatory approvals for scanners use in pathology interpretations. Regulatory approval for scanners will complete the pathology digitalization "loop," allowing the Company to be a leader with a complete work flow solution and transmission solution for the pathology market.

  • Developing inter-site telepathology network. The Company is working with a significant, expanding hospital system in Massachusetts. AccelPath has been approached to develop, implement and manage an intersite telepathology network for optimization of resources across multiple hospital locations.
  • Completed administrative components of merger. In May 2011, the Company changed its name from Technest Holdings, Inc. to AccelPath, Inc., which reflects its current business focus. Commensurate with its name change, the Company changed its trading symbol to "ACLP."
  • Increase customer base and branding. This will allow the Company to continue expanding its footprint nationwide as a recognized reliable, efficient and high-quality provider of digital pathology technology.

Since AccelPath was formed, the Company has been able to achieve its growth and infrastructure development objectives. Management believes the remainder of 2012 should be another exciting period for AccelPath, particularly as the Company expects to further implement its digital pathology workflow solution, continue to expand its services and increase customer penetration while forming strategic alliances. In addition, the Company will take advantage of the 3D technology as it relates directly to digital telemedicine, while developing the non-core 3D imaging technology applications with strategic partners. With its experienced management team, AccelPath expects to meet these established objectives for 2012.

(Added links and graphic above not part of original letter)

 

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Annoucing MikroScan Qumulus, New Cloud-based Digital Pathology Communications Service for Viewing, Management, Sharing, and Analysis of Whole Slide Images

MikroScan Qumulus service offers the fastest, easiest, and most affordable path to step into the future with cloud-based digital pathology communications.

Vista, CA:  Whole slide imaging (WSI) systems manufacturer, MikroScan Technologies, adds a product to its digital pathology communications toolset. MikroScan Qumulus is a monthly service that provides an easy means for hospitals, researchers, or pathologists to store, manage, view, and instantly share whole slide images from anywhere with an Internet connection. MikroScan offers a free 90-day trial account, which takes only minutes to set up and includes 50 gigabytes of storage space.

The new cloud-based service works hand-in-hand with MikroScan’s desktop whole slide scanner, MikroScan D2, and image acquisition software, Q-Skan. The latter can automatically upload the scanned image to your Qumulus account as it saves, providing near-instant remote access to pathologists anywhere in the world.

“We are ecstatic about Qumulus. Its remote Web access features makes pathology communications a breeze and will save our customers thousands of dollars annually in travel and slide transport costs.” Said Bob Goerlitz, president and founder of MikroScan Technologies, Inc. “With our D2 scanner’s low price point and now our Qumulus cloud service low rates, we have effectively removed all economic barriers to entering digital pathology. And with our new leasing options, even the capital expenditure is no longer a speed bump. If you are a pathologist, now there is no reason not to have a MikroScan on your desk.”

“With its immediate remote sharing capability Qumulus is especially useful for consults, research, tumor boards, and educational applications,” said Victor Casas, chief technical officer and applications specialist.

MikroScan Qumulus is Web-based so pathologists can use a Web browser (i.e. Internet Explorer) to access their cases from virtually anywhere. There is no software or hardware investment required, and no need for technical expertise or I.T. personnel to install or maintain.

MikroScan Qumulus is the most affordable service of its kind and costs a fraction of what competing solutions charge. The monthly service includes all cloud software and hardware upgrades as well as automatic backups. There are no storage limits, and no data transfer charges.

MikroScan offers 20-40 minute online product demonstrations of both its scanner and Qumulus viewer. Go to http://www.mikroscan.com or call (760) 736-2180 to request a demo.

About MikroScan Technologies, Inc.

MikroScan Technologies, Inc. founders have been engaged in the design, sales, and marketing of high quality laboratory instruments for more than 26 years. The company specializes in the development of cutting edge whole-slide imaging (WSI) systems and communication tools designed for pathology, biology and research applications. With game changing technology and pricing, MikroScan products represent a leap in advancement and convenience in the evolution of WSI and digital pathology. MikroScan centers its product development on speed of slide image acquisition, exceptional imaging quality, and unmatched affordability that breaks through traditional barriers to digital pathology. For further information visit: http://www.MikroScan.com

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"St. Dennistoun Mortuary" Coin-Operated Automaton LIVE AND IN ACTION!!!

Regular readers of Morbid Anatomy might remember a recent post on this blog about an amazing 1920/30s era coin-operated automaton depictingthe St. Dennistoun Mortuary (yes, really!) that will be going to auction this Saturday. Skinner Auction House just sent along a video of this magnificent machine in action.

Press play above and enjoy. WOW.

The piece is estimated to go for between $4,000-$6,000 as part of an upcoming Science, Technology & Clocks auction taking place Saturday, June 2 at 10:00AM. Full lot description from the Skinner Auctioneers website follows:

Lot 207
"St. Dennistoun Mortuary" Coin-Operated Automaton, attributed to Leonard Lee, c. 1900, the mahogany cabinet and glazed viewing area displays a Greek Revival mortuary building with double doors and grieving mourners out front, when a coin is inserted, doors open and the room is lighted revealing four morticians and four poor souls on embalming tables, the morticians move as if busily at work on their grisly task and mourners standing outside bob their heads as if sobbing in grief, ht. 30 1/2, wd. 24, dp. 17 1/4 in.

Estimate $4,000-6,000

Brass coin plate stamped J. Dennison Leeds NO. 80

As I said before, whoever buys this, please (please!!!) let me come over to meet it! You can find out more about it here.

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Tonight! Erik Jan Hanussen: Hitler's Jewish Clairvoyant: An Illustrated Lecture and Screening with Mel Gordon, Author of "Erik Jan Hanussen: Hitler's Jewish Clairvoyant" at Observatory

Tonight at Observatory! Mel Gordon is one of our all-time most fascinating and charismatic speakers, and an inspiring historian of all things fringe, forgotten, and perverse. His lectures are simply not to be missed. Hope to see you at Observatory this evening!

Erik Jan Hanussen: Hitler's Jewish Clairvoyant: An Illustrated Lecture and Screening with Mel Gordon, Author of "Erik Jan Hanussen: Hitler's Jewish Clairvoyant"
An illustrated lecture and screening of "lost footage" with Mel Gordon, author of Erik Jan Hanussen: Hitler's Jewish Clairvoyant and Grand Guiginol: Theatre of Fear and Terror
Date: Sunday, June 3 (please note date change from Monday, June 4)
Time: 8:00
Admission: $8

Presented by Morbid Anatomy

"Historians digging into the archives to reconstruct the chronicle of the Twentieth Century will have to deal with this strange phenomenon of Erik Jan Hanussen, born Herschmann Steinschneider in the humble home of a poor Jewish actor in Vienna. It will be their task to unravel a complex maze of reality and legend, myth and romance, to reach the core of the true personality of Steinschneider, alias Hanussen, and his influence on one of the most significant chapters of European history, the ascent and reign of Adolf Hitler." --Pierre van Paassen, Redbook Magazine, "The Date of Hitler's Fall," May 1942

When Pierre van Paassen, the prominent Dutch author and foreign correspondent, wrote the above for McCall's Redbook Magazine, the "amazing exploits of Erik Jan Hanussen" were still hot international filler. What could have been more titillating than the true and enigmatic story of a Jewish mystic who helped usher in the Third Reich before  becoming one of its first victims?

Tonight, join Mel Gordon--author of Erik Jan Hanussen: Hitler's Jewish Clairvoyant--for an illustrated lecture on the amazing story of Hitler's Jewish Clairvoyant featuring a special screening of "lost" film footage from Hanussen's 1919 "Hypnosis: Hanussen's First Adventure," a Caligari-like story of sex magic and the occult, and other documentary sources. Books will also be available for sale and signing.

Mel Gordon is the author of Erik Jan Hanussen: Hitler's Jewish Clairvoyant, Grand Guiginol: Theatre of Fear and Terror, Voluptious Panic: The Erotic World of Weimar Berlin, and many other books. Voluptious Panicwas the first in-depth and illustrated book on the topic of erotic Weimar; The lavish tome was praised by academics and inspired the establishment of eight neo-Weimar nightclubs as well as the Dresden Dolls and a Marilyn Manson album. Now, Mel Gordon is completing a companion volume for Feral House Press, entitled Horizontal Collaboration: The Erotic World of Paris, 1920-1946. He also teaches directing, acting, and history of theater at University of California at Berkeley.

More here.

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AG agrees to DNA tests in convicted killer's case

After more than a decade of unsuccessful efforts to obtain DNA testing of evidence collected at the scene of a 1993 Pampa murder that sent him to death row, Henry Skinner won a major battle Friday when Texas Attorney General Greg Abbott recommended to a state appeals court that the testing take place.

In a filing with the Texas Court of Criminal Appeals, which is considering Skinner's latest request for the tests, Abbott said the state and Skinner's lawyers have reached a "preliminary understanding" to do the testing. The court still must approve the lawyers' agreed order.

Skinner, 50, was sentenced to die for the 1993 New Year's Eve murder of his girlfriend and her two adult sons. The convicted killer has argued that he had lost consciousness after consuming alcohol and codeine and, therefore, was not able to bludgeon the woman or stab her sons.

While some evidence had been subjected to DNA testing, clothing, knives and biological samples, including specimens from a rape examination, have not been tested.

Skinner has had at least two execution dates set. Last November, the appeals court issued a stay to ascertain how revised laws regarding such testing may apply to his case.

In his filing, Abbott said the state dropped its objections to testing "in the interest of justice." The attorney general also told the court the state will request testing of additional items submitted by prosecutors.

Skinner's lawyer, Rob Owen, visiting professor at Northwestern School of Law, said prosecutors had "squandered" an opportunity to test the items 12 years ago by barring defense counsel from a role in the deciding the issue.

"Texans expect accuracy in this death penalty case, and the procedures to be employed must ensure them confidence in the outcome," Owen said in an email. "To that end, all determinations about how and by whom the evidence will be handled and tested must be entirely transparent with both parties involved in every step."

allan.turner@chron.com

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AG agrees to DNA tests in convicted killer's case

Posted in DNA

Biologists construct self-assembling tiles of DNA

Harvard biologists have brought new meaning to the term "fine print" by devising microscopic tiles made of DNA that self-assemble into letters, Chinese characters, emoticons and other shapes.

More than mere doodling, their advance, detailed this week in the journal Nature, could make it easier and cheaper to build tiny DNA devices capable of delivering drugs or aiding the study of biochemistry, scientists said.

"This technique will accelerate the research field of DNA nanotechnology," said Ebbe Sloth Andersen, a researcher at Aarhus University in Denmark who collaborated on an editorial that accompanied the report.

In its usual role as a warehouse for storing genetic information, DNA helps build humans and hummingbirds, maple trees and meerkats all sorts of complex organisms. But as a building material for machines smaller than the smallest bacterium, it has been tough to control.

Since the early 1980s, engineers have experimented with a variety of approaches to create structures out of DNA, including the use of tiles small bricks woven together out of several strands of DNA that could stick to one another and self-assemble into shapes.

But when researchers tried to construct precisely defined shapes, they ran into trouble, said Peng Yin, a systems biologist at Harvard's Wyss Institute in Boston and senior author of the Nature study. The tiles tended to stick together incorrectly, resulting in incomplete structures.

"People thought this couldn't work," Yin said.

But he and his collaborators pressed on, ultimately designing bricks out of single rather than multiple strands of DNA.

The strands each had four sequences of 10 or 11 bases, which could bind to complementary sequences of 10 or 11 bases on other tiles. If all four sequences on the edges of a tile bind with their matching counterparts on neighboring tiles, the tile assumes a rectangular shape.

The scientists programmed the tiles to stack up in a staggered formation, like a miniature brick wall. Then they created shapes by leaving out tiles at certain locations of their 64-by-103-nanometer "molecular canvas."

Continued here:
Biologists construct self-assembling tiles of DNA