DNA Clears Death Row Inmate

NEW ORLEANS

Damon Thibodeaux received the ovation you'd expect of a man who's just been exonerated of a crime he didn't commit.

WGNO News Reporter Darian Trotter asked, "How do you feel now?" "Free," Thibodeaux replied.

Damon Thibodeaux has been on death row in Louisiana since October, 1997.

He was convicted of the murder and rape of his 14-year old step-cousin, Crystal Champagne.

It was a crime for which he had been coerced into falsely confessing.

But DNA and other evidence have proven his innocence.

It took seven years and hundreds of thousands of dollars of DNA testing for the Innocence Project and Jefferson Parish prosecutors to exonerate Thibodeaux.

"When you think you have an innocent man and people on both sides can get together and really share evidence and conduct an investigation into the search for the truth that's what's important. So we are tremendously indebted to Paul Connick and his team for the cooperation and the integrity with which they went about this process," Innocence Project Co-Director Barry Scheck said.

Thibodeaux makes the 300th person to be exonerated by DNA evidence in the U.S. And the 18th who served time on death row.

More here:
DNA Clears Death Row Inmate

Posted in DNA

Journal of Microbiology & Biology Education selected for inclusion in PubMed Central

Public release date: 28-Sep-2012 [ | E-mail | Share ]

Contact: Leslie Robinson lrobinson@asmusa.org 202-737-3600 American Society for Microbiology

The Journal of Microbiology & Biology Education (JMBE), an online open-access journal of the American Society for Microbiology and the premier journal for microbiology and biology education research, has been selected for indexing by PubMed Central.

"Sharing solid, peer-reviewed research extends the value of the research and produces cost-effective benefits to society," says JMBE Editor-in-Chief Christopher J. Woolverton, who is professor of environmental health sciences at Kent State University, Kent, Ohio. "PubMed Central indexing of the scholarly research published in JMBE will certainly provide great benefit to the students of microbiology and biology, and to the educators who prepare the next generation of scientists. We are excited that the scholarship of our authors will now be accessible through PubMed Central."

Developed and maintained by the National Center for Biotechnology Information, a division of the National Library of Medicine at the National Institutes of Health, PubMed Central is a full-text digital archive of biomedical and life sciences journal literature. To be accepted in the archive, a journal must qualify on the merits of its scientific and editorial content and on the technical quality of its digital files.

Launched in 2000, JMBE is designed to foster scholarly teaching in the biological sciences. The scientific scope of the journal is rooted in microbiology while branching out to biology. The educational scope of the journal is primarily undergraduate education; however, the journal also publishes articles that feature good pedagogy and good design used in kindergarten through high school education or graduate and professional (e.g., medical school) education.

Each issue of JMBE features peer-reviewed, practical tips for teaching, education research and perspectives, innovative classroom and laboratory exercises, and reviews. To access current and past issues, view instructions for authors, or sign up for eTOC alerts, visit http://jmbe.asm.org.

###

The American Society for Microbiology is the largest single life science society, composed of over 39,000 scientists and health professionals. ASM's mission is to advance the microbiological sciences as a vehicle for understanding life processes and to apply and communicate this knowledge for the improvement of health and environmental and economic well-being worldwide.

Read this article:
Journal of Microbiology & Biology Education selected for inclusion in PubMed Central

4 ASM-NSF biology scholars named leadership fellows

Public release date: 28-Sep-2012 [ | E-mail | Share ]

Contact: Leslie Robinson lrobinson@asmusa.org 202-737-3600 American Society for Microbiology

The ASM-NSF Biology Scholars Program is pleased to announce that four Scholar alumni have been chosen for a group created to recommend institutional-level improvements for undergraduate biology education. Teresa C. Balser, Dean, Agricultural and Life Sciences at the University of Florida; Loretta Brancaccio-Taras, Chair, Biological Sciences Department, Kingsborough Community College, Nitya M. Jacob, Chair, Biology Department, Oxford College; and Todd P. Primm, Chair, Biological Sciences Department, Sam Houston State University, have been named Vision and Change Leadership Fellows of the Partnership for Undergraduate Life Sciences Education (PULSE) program.

A joint initiative of the National Science Foundation (NSF), Howard Hughes Medical Institute (HHMI), and National Institutes of Health (NIH), the PULSE program is an effort to support a yearlong program in which fellows consider and then recommend models for improving undergraduate life sciences education. The effort is rooted in recommendations made in Vision and Change in Undergraduate Biology Education: A Call to Action, a report published by the American Association for the Advancement of Science in 2011.

Forty Vision and Change Leadership Fellows were selected from more than 250 applications.

"The fellows represent a diverse group of extremely capable faculty," says Judith Verbeke of NSF. "They bring a variety of experiences that will inform the development of an implementation framework that will transform undergraduate education in the life sciences."

The fellows will produce an implementation framework describing strategies for institutional change. Because a change in institutional culture is needed, PULSE activities are focused on academic departments rather than individual faculty members. The framework document will be available on the PULSE website, and other life scientists are encouraged to review it and provide comments from November 2012 until May 2013.

A full list of the Vision and Change Leadership Fellows is available at http://www.pulsecommunity.org/forum/topics/announcement-v-c-leadership-fellows.

###

Sponsored by a grant [DUE-1022542] from the National Science Foundation, the ASM-NSF Biology Scholars Program is a national leadership initiative that seeks to improve undergraduate biology education based on evidence of student learning. The program has brought together more than 150 Scholars to create and disseminate examples of scholarship in teaching in biology. These examples have been made possible through the program's independent, but intertwined, virtual residency programs the Assessment, Research, and Transitions Residencies. For more information, please visit http://www.biologyscholars.org.

See the rest here:
4 ASM-NSF biology scholars named leadership fellows

Health junket for 76 costs taxpayers $200k

DOZENS of Pathology Queensland staff enjoyed the delights of Darwin this week while their union complains cuts could cripple services.

The Courier-Mail can reveal that 76 staff from Queensland Health's pathology arm took off to the Top End for an annual conference, with $200,000 of their costs covered by taxpayers.

The four-day conference comes amid union warnings the LNP Government's plans to cut about 100 pathology staff would impact patients.

Health Minister Lawrence Springborg yesterday described the number of Queensland Health employees attending the one conference as "eye opening".

However, Mr Springborg said he was not aware of any impact the en masse absence of staff had on services.

However, Together Union secretary Alex Scott said it was a "furphy" for Mr Springborg to claim Pathology Queensland would not be impacted by job cuts if it could cater for conferences.

Mr Scott said 76 was just a fraction of the 1600 pathology workforce and more staff should have attended.

"If we had staff cuts we wouldn't have had people at this conference and the health system as a result would be worse off."

Queensland's contingent to the four-day conference included three pathologists, 23 phlebotomists and laboratory assistants and 50 scientists.

Staged by the Australian Institute of Medical Scientists, the conference came complete with a cocktail function and a special dinner at the Darwin Sailing Club.

Read more from the original source:
Health junket for 76 costs taxpayers $200k

Ventura schools honored for work helping with healthy eating habits

Nutrition took center stage Thursday at Ventura's De Anza Academy of Technology and the Arts as eight schools were honored for their work in getting students to eat better and be more active.

De Anza received the silver award in the U.S. Department of Agriculture's HealthierUS School Challenge. Bronze awards went to Anacapa, Balboa and Cabrillo middle schools and Buena, Foothill, Pacific and Ventura high schools.

USDA Food and Nutrition Service Regional Administrator Allen Ng was on hand for the awards ceremony.

According to Sandip Kaur, director of Nutrition Service for the California Department of Education, the Ventura Unified School District is one of only 16 in the state to be honored for its nutrition program.

"That puts you among the top 5 to 6 percent top districts in California to receive the award," Kaur said. "You have all the ingredients for success."

De Anza Principal Hector Guerrero said credit for the school's successful food and fitness program should go to Sandy Curwood, director of food and nutrition services for the district, and Rebecca Murphy, who runs the cafeteria at De Anza.

"We offered fresh fruits and vegetable in the premises for children to eat every day," Guerrero said. "We've also done away with food as a reward."

De Anza offers a fresh fruit and salad bar each day for 450 to 600 students, as well as healthy entrees, which Thursday included hamburgers on whole wheat buns or turkey sandwiches.

Guerrero said catering to students' palate can be a challenge, but he said schools have found that students make better food choices with offerings of tastings and food preparation lessons.

"They are all required to take a fruit or vegetable, and later on in the day, you'll see them munching carrots or taking raisins to class," Guerrero said. "You don't see as many kids as tired when they are in the classroom."

More here:
Ventura schools honored for work helping with healthy eating habits

$1.7M grant helps students earn microbiology degrees

By Tom Ruiz Date posted: September 28, 2012

Eric Triplett, chair of the University of Floridas Microbiology and Cell Science Department, is pictured in his laboratory.

A team of University of Florida and Miami Dade College faculty members has won a five-year, $1.7 million federal grant to expand a distance-education program enabling MDC students to earn a bachelors degree in microbiology from UF.

The grant was announced in August by the National Science Foundations Division of Undergraduate Education. The grant is part of an NSF effort to increase the number of science, technology, engineering and mathematics graduates, known as the STEM Talent Expansion Program.

We believe this program will allow students to become science graduates who otherwise would be unable to do so for financial or cultural reasons, said Eric Triplett, principal investigator for the grant and chair of UFs Microbiology and Cell Science Department, part of the Institute of Food and Agricultural Sciences. This is one of the very few science degrees available by distance education anywhere in the U.S. from a top research university.

Launched last fall, the program is aimed at students from minority groups traditionally underrepresented in STEM disciplines. Its based at MDCs North Campus, where 90 percent of students are Hispanic or African- American.

With the distance ed option, students can attend UF without relocating to Gainesville, thereby reducing expenses and enabling students to maintain employment and personal responsibilities. These factors could improve retention, said Jennifer Drew, an instructor with the UF microbiology and cell science department and a co principal investigator.

Drew said the funding will help officials at both institutions improve the existing program by offering new features that may improve retention: scholarships, peer-to-peer tutoring, career mentoring and undergraduate research experiences.

Lecture classes are taught online, but students will do their lab work in person at MDC or one of several UF facilities in South Florida.

The program is open to all students, regardless of ethnicity, who have received an associate of arts degree from MDC and earned minimum grades in prerequisite courses. Beginning next fall, UF plans to offer a similar distance-ed program at community colleges across the state, Triplett said.

Read the rest here:
$1.7M grant helps students earn microbiology degrees

Research and Markets: Analysis of Emerging Microbiology Tests and Strategic Profiles of Leading Suppliers

DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/27k7vh/analysis_of) has announced the addition of the "Analysis of Emerging Microbiology Tests and Strategic Profiles of Leading Suppliers" report to their offering.

This 760-page report presents a comprehensive marketing and technological assessment, as well as medical rationale and diagnostic prospects for nearly 100 infectious diseases and viruses, including their scientific background, clinical significance and market needs for new tests, vaccines, drugs and extensive listings of companies developing or marketing innovative technologies and products.

The report also presents strategic assessments of leading market players and emerging suppliers with innovative technologies and products, including their sales, product portfolios, distribution tactics, technological know-how, new products in R&D, collaborative arrangements, and business strategies.

Competitive Profiles:

- Abbott

- Affymetrix

- Beckman Coulter/Danaher

- Becton Dickinson

- bioMerieux

Continue reading here:
Research and Markets: Analysis of Emerging Microbiology Tests and Strategic Profiles of Leading Suppliers

DNA remains focus in Highway of Tears cases

VANCOUVER - RCMP scientists will continue to resubmit DNA to Interpol after announcing this week the process confirmed a dead U.S. convict killed at least one of the 18 victims on B.C.'s so-called Highway of Tears, an investigator said Thursday.

Staff Sgt. Wayne Clary said samples of genetic material submitted to the international law enforcement agency have to meet standards, which could mean having to isolate the suspects DNA from other contaminants, including blood from the victim.

That was the case in victim Colleen MacMillens murder: her blood was mixed with that of her presumed killer, Bobby Jack Fowler. (Fowlers guilt is not proven in a court of law because of his passing in 2006 in an Oregon prison.)

A previous attempt five years ago to separate Fowlers blood was unsuccessful, but new technology made it possible this year. That meant the isolated Fowler DNA was now acceptable for comparison with international police records.

Were very cognizant of advances in DNA and we would resubmit when we can, Clary told QMI Agency. In particular, when there are older cases that have already gone through (our system) once.

The investigator said police have also traced four additional British Columbian male suspects -- two living and two dead -- related to the missing and murdered women.

One of the suspects continues to be sought in connection to Maureen Mosies death. The 33-year-old was last seen alive in Salmon Arm on May 8, 1981. The next day, her remains were located 100 kilometres west, near Kamloops.

Mounties still seek witnesses who saw a two-door compact car with an Alberta plate driven by a man with a dark beard.

We think whoever drove that car killed Maureen Mosie.

Though no names were released, Clary said the two dead suspects linked to two separate killings perished before the Highway of Tears task force launched in 2005.

Read this article:
DNA remains focus in Highway of Tears cases

Posted in DNA

Some Women's Brains Contain Male DNA: Study

Latest Womens Health News

WEDNESDAY, Sept. 26 (HealthDay News) -- Male DNA and cells are commonly found in some women's brains and most likely come from male fetuses, according to a small new study.

The medical implications of male DNA and male cells in women's brains are unknown. Previous studies of microchimerism -- the presence of genetic material and cells that were exchanged between fetuses and mothers during pregnancy -- have linked it to autoimmune diseases and cancer in both helpful and harmful ways.

Researchers at the Fred Hutchinson Cancer Research Center in Seattle analyzed brain autopsy specimens from 59 women who died between the ages of 32 and 101. Male DNA was detected in 63 percent of the women and was distributed in various brain regions. The oldest woman with male DNA was 94.

Thirty-three of the 59 women in the study had Alzheimer's disease. These women had a somewhat lower prevalence of male DNA, which was present in lower concentrations in regions of the brain most affected by Alzheimer's.

Because of the small number of women in the study and their largely unknown pregnancy history, it is not possible to establish a link between Alzheimer's disease and levels of male DNA and cells from a fetus, the researchers said in a cancer center news release.

They also added that the study does not show an association between male microchimerism in women's brains and their health or risk of disease. Further research is needed to investigate this area.

The study was published Sept. 26 in the journal PLoS One.

-- Robert Preidt

Copyright 2012 HealthDay. All rights reserved.

Read the rest here:
Some Women's Brains Contain Male DNA: Study

Posted in DNA

Burn victim identified by DNA in maggots

It isn't pretty, but it's a first for science. A dead body, burned beyond recognition, was discovered in the woods by Mexican police. Investigators had a lead on the identity of the victim, but the body was too damaged to provide DNA for analysis. That is, until scientists stepped in with an innovative and unorthodox solution: extracting DNA from maggots found on the corpse.

Pathologists from the Autonomous University of Nuevo Leon, in San Nicolas, Mexico, dissected three maggot larvae found on the corpse and extracted the contents of their gastrointestinal tracts. They were then able to isolate the human DNA found within and find a match.

Police believed the victim to be a young woman who had been reported missing ten weeks earlier. The DNA from the maggots was compared to samples taken from the woman's father and found to be a 99.68 percent match.

The pathology team, led by Maria de Lourdes Chavez-Briones and Marta Ortega-Martinez, reported their work in the Journal of Forensic Science. The idea of extracting human DNA from insects has been studied for several years. But this was the first time the theory was put to practice in a criminal case.

The team hopes that their work will encourage law enforcement officials to pay more mind to insects found at crime scenes.

See original here:
Burn victim identified by DNA in maggots

Posted in DNA

CEO of Abbott’s spinoff didn’t receive college degrees claimed in filings

September 27, 2012 5:02PM

Updated: September 28, 2012 2:29AM

Abbott Laboratories is shrugging off the fact that the company overstated the education level of the man chosen to helm its pharmaceutical spinoff, which is expected to make $18 billion in sales next year. Longtime Abbott exec Richard Gonzalez didnt receive either a bachelors degree in biochemistry from the University of Houston or a masters in biochemistry from the University of Miami contrary to biographical information filed with the Securities and Exchange Commission in 2007 and several years prior while he was a director at the company. There was an administrative error many years ago when the bio was written, said Abbott spokesman Melissa Brotz. When we became aware of it a while back we corrected it promptly I dont have an exact date. Theres absolutely no issues with his educational background or ability to lead. Hes had a distinguished career reaching the highest levels in the company with a proven track record, said Brotz. Gonzalez will take the reigns of the pharmaceutical spinoff AbbVie when the nascent company completes its separation Jan. 1. AbbVie (pronounced Abb-vee) will be the new research-based pharmaceutical firm expected to be launched by Abbott Laboratories by the end of the year. In October 2011, North Chicago-based Abbott said it would separate into two publicly traded firms one in diversified medical products, the other in research-based pharmaceuticals. AbbVie will include Abbotts current portfolio of proprietary pharmaceuticals and biologics. The name is derived from a combination of Abbott and vie, which references the Latin root vi meaning life. The AbbVie logo and graphic identity will be unveiled when the new company is launched. The diversified medical products company, which will retain the Abbott name, will consist of Abbotts existing products portfolio, including its branded generic pharmaceutical, devices, diagnostics and nutritional businesses. AbbVie has nearly $18 billion in annual revenue and will have a portfolio of market-leading brands, including Humira, Lupron, Synagis, Kaletra, Creon and Synthroid. Gonzalez joined Abbott in 1977 and retired briefly in 2007 as the companys No. 2 man before returning in 2009 to head its investment arm and is currently executive vice president of the pharmaceutical products group. A spokesman for the University of Houston confirmed Gonzalez took classes at the school in 1972 and 1973, but did not earn a degree. School administrators from the University of Miami were not immediately available Thursday. Crains Chicago Business first broke the story.

Visit link:
CEO of Abbott’s spinoff didn’t receive college degrees claimed in filings

CEO of Abbott spinoff lacks degrees claimed in filings

SUN-TIMES MEDIA September 27, 2012 6:58PM

Updated: September 28, 2012 3:00AM

Abbott Laboratories gave incorrect education credentials for the executive chosen to lead its pharmaceutical spinoff in regulatory filings between 2002 and 2007, Crains Chicago Business is reporting.

Richard A. Gonzalez, named CEO of AbbVie, did not receive a biochemistry bachelors degree nor a biochemistry masters degree from the universities Abbott filings listed, Crains reported.

According to Crains, Gonzalez did not receive a bachelors degree in biochemistry from the University of Houston, nor a masters degree in biochemistry from the University of Miami, contrary to claims in Abbotts filings with the U.S. Securities and Exchange Commission when the longtime company executive was a director.

He started at the company in 1977 and retired from Abbott as president and chief operating officer in 2007, but returned two years later.

Gonzalez, 58, currently executive vice president, Global Pharmaceuticals at Abbott, was chosen to be chairman and CEO of AbbVie (pronounced Abb-vee), the new research-based pharmaceutical firm, which is projected to have $18 billion in annual sales after it is spun off later this year.

Abbott external communications Vice President Melissa Brotz confirmed to Crains that Gonzalez did not receive degrees from either university.

The inaccurate information about his education was included in SEC filings as a result of an internal administrative error. She told Crains that Abbott learned about the errors some time ago. The company corrected the information on its Web site immediately after the errors were discovered, she said.

According to the companys Web site, Gonzalez is listed as a research biochemist at the University of Miami School of Medicine and attended the University of Houston, majoring in biochemistry,

Read the original:
CEO of Abbott spinoff lacks degrees claimed in filings

Mayo Clinic finds way to weed out problem stem cells, making therapy safer

Public release date: 27-Sep-2012 [ | E-mail | Share ]

Contact: Jennifer Schutz newsbureau@mayo.edu 507-284-5005 Mayo Clinic

ROCHESTER, Minn. -- Mayo Clinic researchers have found a way to detect and eliminate potentially troublemaking stem cells to make stem cell therapy safer. Induced Pluripotent Stem cells, also known as iPS cells, are bioengineered from adult tissues to have properties of embryonic stem cells, which have the unlimited capacity to differentiate and grow into any desired types of cells, such as skin, brain, lung and heart cells. However, during the differentiation process, some residual pluripotent or embryonic-like cells may remain and cause them to grow into tumors.

"Pluripotent stem cells show great promise in the field of regenerative medicine; however, the risk of uncontrolled cell growth will continue to prevent their use as a therapeutic treatment," says Timothy Nelson, Ph.D., M.D., lead author on the study, which appears in the October issue of STEM CELLS Translational Medicine.

Using mouse models, Mayo scientists overcame this drawback by pretreated stem cells with a chemotherapeutic agent that selectively damages the DNA of the stem cells, efficiently killing the tumor-forming cells. The contaminated cells died off, and the chemotherapy didn't affect the healthy cells, Dr. Nelson says.

"The goal of creating new therapies is twofold: to improve disease outcome with stem cell-based regenerative medicine while also ensuring safety. This research outlines a strategy to make stem cell therapies safer for our patients while preserving their therapeutic efficacy, thereby removing a barrier to translation of these treatments to the clinic," says co-author Alyson Smith, Ph.D.

Stem cell therapies continue to be refined and improved. Researchers are finding that stem cells may be more versatile than originally thought, which means they may be able to treat a wider variety of diseases, injuries and congenital anomalies. Stem cell therapy is an emerging regenerative strategy being studied at Mayo Clinic.

"By harnessing the potential of regenerative medicine, we'll be able to provide more definitive solutions to patients," says Andre Terzic, M.D., Ph.D., co-author and director of Mayo Clinic's Center for Regenerative Medicine.

###

Other members of the Mayo research team included Clifford Folmes, Ph.D., Katherine Hartjes, Natalie Nelson and Saji Oommen, Ph.D. The research was supported by the Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome, National Institutes of Health New Innovator Award OD007015-01, and a Mayo Clinic Center for Regenerative Medicine accelerated research grant.

Continued here:
Mayo Clinic finds way to weed out problem stem cells, making therapy safer

CNIO team discovers the first real indicator of longevity in mammals

Public release date: 27-Sep-2012 [ | E-mail | Share ]

Contact: Nuria Noriega nnoriega@cnio.es Centro Nacional de Investigaciones Oncologicas (CNIO)

A team of researchers from the Spanish National Cancer Research Centre (CNIO), headed by CNIO Director Mara Blasco, has demonstrated in a pioneering study on mammals that longevity is defined at a molecular level by the length of telomeres. The workwhich is published today in the online edition of the journal Cell Reportsopens the door to further study of these cellular components in order to calculate the rate at which cells age and thus be able to determine life expectancy for a particular organism.

Chromosomesthe cellular containers holding the genetic information in living creatureshave repetitive sequences of DNA at their extremities called telomeres. These sequences act as hoods that protect the genetic material in the face of any external agent which might damage it and compromise the function of the cells.

Several transversal population studiesmeasuring telomere length once over time in a large group of individualsshow a relationship between the length of the telomeres and the risk of suffering illnessescardiovascular disease or cancer, for example.

Until now, however, the use of telomeric measurements to predict real life expectancy in mammals had not been evaluated.

"In the transversal studies, it appears that individuals with short telomeres have a significantly increased probability of developing illnesses, including cancer. But this information is not applicable to a specific individual", says Blasco.

To determine a real ageing prediction method, the authors of the present study have carried out longitudinal studies of telomere length in mice, in which a single individual is followed over a period of time.

After taking periodic blood samples from the same individual, from which cells were extracted for study, they found that those mice which managed to live longer were not the ones that had longer telomeres at any given age but those in which showed less telomeric shortening over time.

"The important thing is not so much the long telomeres at any given time as the tendency or the evolution of the length of the telomeres over time", says Elsa Vera, lead author of the study.

Read more:
CNIO team discovers the first real indicator of longevity in mammals

First real indicator of longevity in mammals discovered

ScienceDaily (Sep. 27, 2012) A team of researchers from the Spanish National Cancer Research Centre (CNIO), headed by CNIO Director Mara Blasco, has demonstrated in a pioneering study on mammals that longevity is defined at a molecular level by the length of telomeres. The work -- which is published September 27 in the online edition of the journal Cell Reports -- opens the door to further study of these cellular components in order to calculate the rate at which cells age and thus be able to determine life expectancy for a particular organism.

Chromosomes -- the cellular containers holding the genetic information in living creatures -- have repetitive sequences of DNA at their extremities called telomeres. These sequences act as hoods that protect the genetic material in the face of any external agent which might damage it and compromise the function of the cells.

Several transversal population studies -- measuring telomere length once over time in a large group of individuals -- show a relationship between the length of the telomeres and the risk of suffering illnesses -- cardiovascular disease or cancer, for example.

Until now, however, the use of telomeric measurements to predict real life expectancy in mammals had not been evaluated.

"In the transversal studies, it appears that individuals with short telomeres have a significantly increased probability of developing illnesses, including cancer. But this information is not applicable to a specific individual," says Blasco.

To determine a real aeing prediction method, the authors of the present study have carried out longitudinal studies of telomere length in mice, in which a single individual is followed over a period of time.

After taking periodic blood samples from the same individual, from which cells were extracted for study, they found that those mice which managed to live longer were not the ones that had longer telomeres at any given age but those in which showed less telomeric shortening over time.

"The important thing is not so much the long telomeres at any given time as the tendency or the evolution of the length of the telomeres over time," says Elsa Vera, lead author of the study.

With this study, Blasco's team suggests using mice as an animal model in longitudinal studies that allow for health prognoses in humans. Blasco says that: "while telomere length in normal mice is much greater than in humans, we have found, surprisingly, that the telomere shortening rate in mice is 100 times faster than in humans, so the old dogma of normal mice not getting old due to the shortening of their telomeres is wrong."

This study further opens the possibility of studying, via the longitudinal examination of these genetic guardians, the real effect of lifestyle choices such as diet, smoking or exercise on individual aging rates.

Read the original here:
First real indicator of longevity in mammals discovered

Many female brains contain male DNA

In the first study of its kind, researchers have discovered that male DNA is commonly found in the brains of women a finding that could hold important implications for diseases like Alzheimers disease and cancer.

Male DNA is likely transferred to female brains during pregnancy, according to researchers from the Fred Hutchinson Cancer Research Center in Seattle. During this time, mothers and fetuses exchange and harbor genetic material and cells in a phenomenon called microchimerism.

This means, if a mother is pregnant with a boy, she will end up with male DNA in her system potentially for the rest of her life. If the fetus is female, the mother will end up with genetic material from her daughter, though it is difficult for researchers to distinguish between two sets of female DNA in microchimerism studies.

What this means for treating diseases

Prior studies have observed fetal DNA in many other of the mothers tissues and organs, but this is the first to confirm fetal cells can cross the blood-brain barrier and reside in the mothers brain beyond pregnancy.

We were interested in looking at the human brain because its never been looked at before, and it was really unknown if the cells of fetal origin could reach the brain, study senior author Dr. Lee Nelson, a member of the Fred Hutchinson Cancer Research Center and professor of medicine at the University of Washington, told FoxNews.com. Nelson and her colleagues performed autopsies on 59 brains of deceased females and detected male microchimerism in 63 percent of them.

Male microchimerism was distributed across multiple regions of the female brain, including those affected by dementia, and could persist for decades potentially even an entire human lifespan. According to the study, the oldest female with microchimerism detected in her brain was 94.

The question naturally arises what role might the cells have in benefiting health and what role they play in diseases, Nelson added.

The researchers hope further studies on microchimerism might shed new light on various diseases that affect the brain, such as Alzheimers, Parkinsons or even brain tumors.

These cells have access to the brain could help us understand different treatment options for diseases that arent well treated, Nelson said. Its a very exciting new area that opens up different possibilities, such as, what if these cells have anti-tumor potential? For example, glioblastomas are deadly tumors, (which) have poor treatment options. Were very much in need of new potential options.

See more here:
Many female brains contain male DNA

Posted in DNA

DNA Mapping Uncovers the Mystery to Family History

NEW YORK--(BUSINESS WIRE)--

Scientific breakthroughs in the study of the human genome coupled with online access to massive genealogical records have opened the doors of ancestral investigation to include all those interested in unearthing their roots and, on October 26-27 at the Metropolitan Pavilion in New York City, The Genealogy Event will feature exciting learning opportunities and resources for both novice and professional enthusiasts.

Technology has revolutionized genealogical research and can take you back more than 100,000 years, said Bridget Bray, organizer of the event. Uncovering the mystery and discovering your own history doesnt have to mean hours of pouring over dusty record books locked in courthouse basements. So much of your familys past has been right there in your own DNA, waiting for science to catch up and read it.

DNA testing and analysis has evolved dramatically in recent years casting the widest net possible to ones genetic matrix, said Ken Chahine, SVP and General Manager of AncestryDNA, sponsor of The Genealogy Event. AncestryDNA has merged this new technology with the millions of family trees and billions of records on Ancestry.com providing exciting new family history discoveries for those new to the hobby as well as the most dedicated researcher.

According to Family Tree DNA President Bennett Greenspan, exhibitor and speaker at The Genealogy Event, Through an examination of the Mitochondrial DNA for women the Y-Chromosome for men, we can look at the direct female and male linesgenealogically and anthropologicallyback to the first woman and man who lived in Africa more than 100,000 years ago.

The Genealogy Event will feature 40 expert speaking sessions including ones that demonstrate how an analysis of your DNA can also provide a breakdown of ethnic percentages and reveal the parts of the world from which an individuals ancestors came. Testing could even bring to light distant relations around the globe going back 400 years.

Attendees will also connect with a host of companies, organizations and societies that offer essential services to the genealogical industry.

According to Bray, People have always been fascinated by where they come from, telling and retelling the stories handed down from their elders. Popular shows like Finding Your Roots with Henry Gates, Jr. and Who Do You Think You Are? which trace the heritage of famous personalities have underscored this interest and demonstrated how science can help to expose unknown ethnicities, dispel family myths and reveal even more thrilling truths.

New York City is a melting pot within a melting pot and we are thrilled to present The Genealogy EventNYCs only event of its kindto put people in touch with their pasts. And its all for about the price of a movie ticket, she said.

For more information and to pre-register online for The Genealogy Event, visit http://www.thegenealogyevent.com. Tickets are available for $15 per day.

Link:
DNA Mapping Uncovers the Mystery to Family History

Posted in DNA

Bearing Sons Leaves Male DNA Traces in Mom's Brain

By Melissa Lee Phillips, ScienceNOW

Giving a whole new meaning to pregnancy brain, a new study shows that male DNA likely left over from pregnancy with a male fetus can persist in a womans brain throughout her life. Although the biological impact of this foreign DNA is unclear, the study also found that women with more male DNA in their brains were less likely to have suffered from Alzheimers disease hinting that the male DNA could help protect the mothers from the disease, the researchers say.

During mammalian pregnancy, the mother and fetus exchange DNA and cells. Previous work has shown that fetal cells can linger in the mothers blood and bone for decades, a condition researchers call fetal microchimerism. The lingering of the fetal DNA, research suggests, may be a mixed blessing for a mom: The cells may benefit the mothers health by promoting tissue repair and improving the immune system but may also cause adverse effects, such as autoimmune reactions.

One question is how leftover fetal cells affect the brain. Researchers have shown that fetal microchimerism occurs in mouse brains, but they had not shown this in humans. So a team led by autoimmunity researcher and rheumatologist J. Lee Nelson of the Fred Hutchinson Cancer Research Center in Seattle, Washington, took samples from autopsied brains of 59 women who died between the ages of 32 and 101. By testing for a gene specific to the Y chromosome, they found evidence of male DNA in the brains of 63 percent of the women. (The researchers did not have the history of the womens pregnancies.) The male DNA was scattered across multiple brain regions, the team reports online today in PLoS ONE.

Because some studies have suggested that the risk of Alzheimers disease (A.D.) increases with an increasing number of pregnancies, the team also examined the brains for signs of the disease, allowing them to determine whether A.D. correlated with the observed microchimerism. Of the 59 women, 33 had A.D. but contrary to the teams expectation, the women with A.D. had significantly less male DNA in their brains than did the 26 women who did not have A.D..

Whether that correlation means that fetal male DNA helps protect women against A.D. is unclear, however. To me, this suggests that the presence of fetal cells in the female brain prevents disease, says cardiologist Hina Chaudhry of Mount Sinai School of Medicine in New York City.

In a study published online in Circulation Research late last year, Chaudhry and colleagues found that fetal cells in mice migrated to the mothers heart, differentiated into functioning cardiac cells, and accelerated repair to damaged heart tissue. So, Chaudhry says, a similar thing could be happening when fetal cells migrate to the brain. I would bet these cells are getting into the maternal brain and are able to differentiate into neurons.

A 2010 study in Stem Cells and Development showed that fetal cells can migrate to the brain of a mother mouse and mature into neurons, Nelson says. But, she adds, it remains unclear if something similar is happening in humans and its also difficult to reach any firm conclusions about a potential link between microchimerism and A.D. Part of the problem is that her team had little information about the pregnancy histories of the women in their study. We have to say we really dont know, she says. I hope that kind of work can be done in the future, but its very difficult to do with human samples.

This story provided by ScienceNOW, the daily online news service of the journal Science.

See the original post here:
Bearing Sons Leaves Male DNA Traces in Mom's Brain

Posted in DNA

New drive to take criminals' DNA

27 September 2012 Last updated at 13:20 ET

Police forces in England and Wales have begun a large-scale operation to collect DNA samples from about 12,000 serious offenders who are not on the national DNA database.

Operation Nutmeg will see officers collect swabs from sex offenders and murderers living in the community.

Criminals are often not on the database if they were convicted before 1994, when sample-taking became routine.

The scheme has been launched after a successful pilot exercise in Hampshire.

Police hope the collection of thousands of new samples could help to solve so-called cold-cases, where a new sample is linked to a past crime.

Speaking at a briefing on Thursday, Amanda Cooper, director of information, science and technology at Thames Valley Police, said officers would approach individuals between now and next summer to collect the samples.

Police forces have been given lists of offenders living in their areas and will work though them to collect the samples.

The lists have been drawn up based on information from the Police National Computer, which was first used in the 1970s.

Alex Marshall, the chief constable of Hampshire police, said 167 samples were taken from a list of 471 convicted criminals during the pilot operation.

Visit link:
New drive to take criminals' DNA

Posted in DNA