Woman charged in husband's death gives DNA sample

LOS ANGELES (AP) -- A nationally known professional tennis referee charged with the coffee-cup killing of her husband gave police a DNA sample Wednesday after dropping her opposition to the procedure.

Lois Ann Goodman, 70, who is charged with beating her husband to death with the cup last April, was accompanied by about 25 supporters, including friends and relatives, when she appeared briefly in court for a pretrial hearing.

A judge scheduled Goodman's next hearing for Nov. 8.

In the meantime, defense attorneys say they have a huge amount of evidence and court documents provided by prosecutors to review before a trial is scheduled. They also demanded to see original notes taken at Goodman's home by police officers who initially ruled the case an accidental death. In addition, they are seeking notes and recordings from coroner's investigators and the mortician who examined the body.

Goodman was arrested in August just before she was to referee at match at the U.S. Open.

Her attorneys say her 80-year-old husband was the victim of a freak accident.

Authorities initially believed Alan Goodman fell down stairs at home while she was away but later decided it was homicide. Prosecutors now believe he was struck 10 times on the head and stabbed with the broken cup.

The couple was married nearly 50 years with three grown children.

Defense attorneys Alison Triessl and Robert Sheahen told reporters that they anticipate surprise revelations in the case after all of the discovery materials are reviewed. They had opposed having Goodman provide a DNA sample but relented after losing an appeal on the issue.

''No DNA sample is going to prove anything,'' said Sheahen. ''Proving that her DNA is in her own home is ridiculous.''

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Woman charged in husband's death gives DNA sample

Posted in DNA

Referee charged in husband's death gives DNA sample

Lois Ann Goodman, 70, is charged with beating her husband to death with a coffee cup.

Andrew Burton/Reuters

LOS ANGELES (AP) -- A nationally known professional tennis referee charged with the coffee-cup killing of her husband gave police a DNA sample Wednesday after dropping her opposition to the procedure.

Lois Ann Goodman, 70, who is charged with beating her husband to death with the cup last April, was accompanied by about 25 supporters, including friends and relatives, when she appeared briefly in court for a pretrial hearing.

A judge scheduled Goodman's next hearing for Nov. 8.

In the meantime, defense attorneys say they have a huge amount of evidence and court documents provided by prosecutors to review before a trial is scheduled. They also demanded to see original notes taken at Goodman's home by police officers who initially ruled the case an accidental death. In addition, they are seeking notes and recordings from coroner's investigators and the mortician who examined the body.

Goodman was arrested in August just before she was to referee at match at the U.S. Open.

Her attorneys say her 80-year-old husband was the victim of a freak accident.

Authorities initially believed Alan Goodman fell down stairs at home while she was away but later decided it was homicide. Prosecutors now believe he was struck 10 times on the head and stabbed with the broken cup.

The couple was married nearly 50 years with three grown children.

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Referee charged in husband's death gives DNA sample

Posted in DNA

Inherited Diseases Found Sooner in Newborns With DNA Scan

Scanning the DNA of sick infants using a new speed-reading method can diagnose rare genetic disorders in two days instead of weeks, according to research that brings gene mapping a step closer to everyday hospital use.

Researchers at Childrens Mercy Hospitals and Clinics in Kansas City, Missouri, created software that takes raw data from DNA scanning machines and combs though hundreds of genetic disorders to spot disease-causing mutations. The system provided likely diagnoses for three of four sick babies in about two days, results published in Science Translational Medicine found.

The new method has the potential to make genome sequencing practical for neonatal intensive care units, enabling doctors to diagnose mysterious genetic diseases more quickly, said Stephen Kingsmore, director of the Center for Pediatric Genomic Medicine at Childrens Mercy and a study senior author. Fast diagnoses of sick babies could lead to life-extending treatments sooner in some or help avoid futile, costly therapies in others.

This is the biggest breakthrough in this technology for clinical applications we have seen in a few years, said David Dimmock, a geneticist at the Medical College of Wisconsin and Childrens Hospital of Wisconsin in Milwaukee, who wasnt involved in the study. The ability to sequence and interpret a genome in less than week is huge.

Dimmock said researchers at his institution were working on a similar fast genome interpretation system, but hadnt published the results yet. They beat us to the punch, he said.

There are about 3,500 known genetic diseases of which 500 have treatments, Kingsmore said. Many of these genetic illnesses hit young kids. Roughly 20 percent of infant deaths are caused by genetic conditions, according to the study released today.

The Childrens Mercy Hospital system was made possible in part by a new sequencing machine developed by San Diego-based Illumina Inc. (ILMN) that can decode an entire DNA sequence of a person in one day. This generates a colossal volume of raw data that must be analyzed by expert genetic researchers, a process that previously has taken weeks or months.

Heres where the system devised by Childrens Mercy researchers comes into play. Kingsmore and his team devised smart software that allows treating doctors to enter in a sick babys symptoms. The software then matches these reported symptoms to known genetic diseases that have similar symptoms, and scans through the babys genome results for likely harmful mutations in relevant genes.

We think this is going to transform the world of neonatology, Kingsmore said during a conference call with reporters. Until now, this was just not possible to get whole genome scan results quickly enough to help sick newborns in intensive care units, he said. Babies either died or else got better and were discharged home before the results of a gene test were returned.

For cases in which treatments are available, spotting the cause of a disease sooner may allow treatments to be started before it is too late, he said. Kingsmore estimated the total cost of the test to be about $13,500.

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Inherited Diseases Found Sooner in Newborns With DNA Scan

Posted in DNA

How synthetic biology will change us

Lisa Poole / AP file

Harvard geneticist George Church shows off the DNA sequence of a colleague.

By Alan Boyle

In the future, genetically modified organisms could be making our medicines, our fuel, our housewares, our houses and they could even help us remake ourselves. All that may sound like science-fiction, but the future is already arriving, in the form of the bioplastic bottle you may be holding in your hand. Harvard geneticist George Church lays it all out in a new book, "Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves," written with Ed Regis.

"We are already remaking ourselves and our world, retracing the steps of the original synthesis redesigning, recoding and reinventing nature itself in the process," they write.

Even the book has been reinvented through DNA: "Regenesis" is one of those rare books that's been the focus of a research paper in the journal Science. All of its 53,426 words, along with 11 images and one Javascript app, were encoded into chunks of DNA, and then read back, just to prove it could be done. But DNA as a next-generation information storage medium is just one of the applications addressed in "Regenesis" and that's not really all that far out.

If you want to talk about far-out, how about regenerating extinct species, ranging from woolly mammoths to Neanderthals? How about synthetic methods for photosynthesis, the process that turns carbon dioxide, water and sunlight into oxygen and fuel? How about tweaking the human genome to make ourselves immune to multiple viruses? Heck, why not make ourselves virtually immortal?

Basic Books

"Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves" is written by Harvard geneticist George Church and science writer Ed Regis.

"Regenesis" explores all these issues the possibilities and the realities, the pros and the cons. Not even the sky is the limit: "We need to get at least some of our genomes and cultures off of this planet or trillions of person-years will be lost," Church and Regis write. They believe that biotechnology is the key to immortality, for the human species and perhaps for individual humans as well. But is all this a biotech pipe dream? I did a reality check during a telephone interview with Church this week. Here's an edited transcript of the Q&A:

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How synthetic biology will change us

Upstate students ace biology but earn F in history section of state test

ANDERSON High school students in Anderson, Oconee and Pickens counties know their biology but need to brush up on the Bill of Rights.

Scores released to the public by the state Department of Education Tuesday indicate As in biology and Fs in the U.S. History and Constitution portions of the End-of-Course-Examination Program.

The test measures how well high school and some middle school students grasp core subjects including English, biology, algebra and history. The scores reflect testing from the 2011-12 school year.

Generally, students in certain grades take certain subject tests, said Jay Ragley, spokesman for the South Carolina Department of Education.

Ninth-graders and some gifted and talented eighth-graders take the English and algebra sections. Ninth- and tenth-graders take biology, and 11th-graders take the U.S. History and Constitution section. End-of-course subject exams account for 20 percent of each students final grade, and all students enrolled in a given subject must take the test.

School districts received letter grades based on percentages of those who passed and failed.

Students in Anderson, Oconee and Pickens counties made the most As in Biology 1 and 2 and made the most Fs in U.S. History and Constitution. None of the districts overall history scores were failing. Their mean scores ranged from 67 to 75. Anderson School District 3 had the most students receive Fs in the history test with 62 percent scoring poorly. Anderson School District 5 had the lowest number of students receiving Fs at 36 percent.

Biology proved a strong point with at least 25 percent of all test takers in Anderson, Oconee and Pickens school districts making an A. That subject showed the most improvement statewide in pass rate and average score, which grew by 8 percent and 3 percent.

State Superintendent Mick Zais said the testing benefits teachers and students.

Measuring student achievement is an important tool to improving instructional practices, he said. End-of-course assessments demonstrate how well high school students have mastered key concepts and skills they will use after graduation.

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Upstate students ace biology but earn F in history section of state test

Pondicherry University to hold conference

The Department of Biochemistry and Molecular Biology, Pondicherry University, will hold a two day national conference on current scenario and emerging trends in hepatocellular diseases.

According to a university release here today, the conference will focus on the key aspects of hepatology research, and strategies to explore liver at the cellular and molecular level.

"Liver is a vital organ in our body as it plays a central role in metabolic regulation and toxin excretion.

Liver is constantly exposed to a variety of stress due to our modern lifestyle adaptations, including tendency to avail drugs and substances, alcohol and fatty foods, resulting in liver injury, specifically to liver cells, hepatocytes. This leads to malfunction and disease conditions of the liver," the release said.

"The damage caused to liver worsens with time and hence it is essential to find a cure or treatment option via biocompatible drugs, herbal medicines and drugs at nanomolar concentrations which can help the liver cells to recuperate even at very minute concentrations," the release further added.

The conference would highlight the recent advances in the field of hepatology research and its future perspectives in various angles. (UNI)

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Pondicherry University to hold conference

Scholar dreams of finding cure for Alzheimer’s disease

MORGANTOWN As a little girl, Joy Wang couldnt grasp what was happening with her paternal grandmother.

Joy and her parents would visit Grandma, yet she did not recognize them, didnt even remember her own son.

The pain from those experiences changed Joys career plans from owning a zoo to curing Alzheimers, and she picked West Virginia University as the place to get the education to make that a reality.

WVU has a great biochemistry program and that will help guide me for the rest of my life, Joy said days before her official start on campus this month. WVU will be like a second family to me. Its always stood out from the rest as having a great atmosphere. Not only will I get support from my group of friends, but from faculty and staff. Everyone is so welcoming. I feel so accepted even though I havent attended classes yet.

Leola Humphries, known as Verna, suffered from dementia. She passed away when Joy was a teen. When Joy grew older, she began to realize on a deeper level the afflictions of her grandmothers illness.

It opened my eyes to how horrible neurological diseases are, Joy said, and it gave me the ability to sympathize with others.

Now I use that pain and those memories as a driving force, a real motivating factor to remind me of what Im doing.

What Joy is doing is working toward her dream to help people like her grandmother by becoming a neurosurgeon. Joy wants to find cures for Alzheimers disease and other disorders of the brain.

Quite ambitious for an 18-year-old. Yet the dream seems entirely attainable with a glance at Joys resume and work ethic thus far. She was part of the National Honor Society, marching band, student council, quiz bowl team, orchestra and swim team at Capital High School in Charleston. She graduated first in her class.

Joy literally could have gone anywhere to begin her journey.

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Scholar dreams of finding cure for Alzheimer’s disease

Dr. Alex Levenberg to Lecture on RF Solutions for Non-invasive Wrinkle Treatment at the Upcoming XII International …

Dr. Levenberg will present a clinical talk about Fractional RF Treatment for wrinkle reduction and skin tightening. He will also demonstrate Pollogen's TriLipoMED procedure - an advanced aesthetic breakthrough that allows practitioners to treat 4 layers of skin tissue with a single system delivering wrinkle reduction, skin tightening, wrinkle prevention, cellulite treatment, fat reduction and more.

(PRWEB) October 03, 2012

Dr. Levenberg's first clinical lecture will address Fractional RF Treatments for Wrinkle Reduction and Skin Tightening. His second lecture will present Pollogen's Maximus platform and TriLipoMED procedure - a non-invasive wrinkle reduction, skin tightening and body contouring treatment that treats 4 layers of skin - the epidermis, dermis, hypodermis and muscle.

During a 1 hour workshop Dr. Levenberg will conduct live demonstrations of the Maximus which includes 4 applicators - 3 applicators of different sizes delivering Pollogen's patented TriLipo technology for facial and body contouring and 1 fractional applicator delivering patented TriFractional technology for advanced skin resurfacing.

Dr. Levenberg stated "I have been using TriLipo for some time, and I am continuously impressed by the immediate anti-aging results. My patients are also consistently pleased with the immediate results. Treatment is completely non-invasive, short and pleasant."

Mr. Amichai Bar-Nir, Pollogens CEO stated: We are pleased that Dr. Levenberg will be presenting TriLipoMED procedure to such a distinguished medical community."

"Pollogen is constantly striving to develop the most cutting- edge technology that delivers dramatic anti-aging and body contouring results, in safe, effective and convenient procedures.

About Pollogen

Pollogen Ltd. is a global leader in the medical aesthetic market, providing professionals in over 60 countries with a wide variety of advanced aesthetic solutions to best serve their customers. Pollogen is the developer and manufacturer of three revolutionary technologies under the industry premier brand names TriPollar, TriLipo and TriFractional and offers a full line of clinically-proven, safe and effective, non-invasive anti-aging facial and body contouring treatment platforms for a range of aesthetic applications including circumference reduction, cellulite reduction and skin tightening. For more information, visit pollogen.com.

PollogenExpect More: More Innovation, More Results, More Service.

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Dr. Alex Levenberg to Lecture on RF Solutions for Non-invasive Wrinkle Treatment at the Upcoming XII International ...

Age Management MD Experts Gather in Chicago for Anti-Aging CME Workshop

Ageology's age management workshop highlights nutrition, adrenal fatigue and saliva testing and lead by Dr. Paul Savage, David Zava, Dr. Vesna Skul and Dr. James Wilson

Chicago, IL (PRWEB) October 03, 2012

Ageologys age management workshop will feature topics such as nutrition, fatigue and saliva testing to get area physicians up to date on the latest research and best practices for age management and anti-aging healthcare.

Dr. Paul Savage, CEO of Ageology and an expert in hormone replacement therapy, will serve as the facilitator for the age management workshop. The presenters are David Zava, Dr. Vesna Skul and Dr. James Wilson. http://ageology-eorg.eventbrite.com/

Weve gathered some of the foremost experts on age management to offer Chicago physicians an in-depth look at the current trends and best practices in anti-aging medicine, Savage says. Im honored to facilitate a roundtable with these prominent age management physicians and am confident all who attend will walk away with a new perspective on anti-aging medicine.

Dr. Zava is president and CEO of ZRT Laboratory, a CLIA certified diagnostic laboratory that supports health care professionals in health management through accurate, convenient and innovative lab testing. Dr. Zava is a biochemist with extensive experience in breast cancer research and an internationally known speaker on breast cancer, hormone replacement therapy and saliva hormone testing.

A graduate of Rush Medical College in Chicago, Dr. Skul is a board certified specialist in Internal Medicine, a Fellow of the American College of Physicians and an Associate Professor of Medicine at Rush University. She has been among Chicagos top doctors as reported by Chicago magazine for nearly a decade and is founder and medical director of the Comprehensive Center for Womens Medicine, a multispecialty holistic medical practice for women.

Dr. Wilson coined the term adrenal fatigue to identify a specific kind of chronic tiredness that many people experience. After decades of working with stressed patients, Dr. Wilson wrote an easy-to-understand guide on stress and health, Adrenal Fatigue: The 21st Century Stress Syndrome, for the many individuals experiencing adrenalfatigue.

Wilson has three doctorates and two master's degrees, all in different health-related disciplines. He received his Ph.D. in Human Nutrition from the University of Arizona, with minors in Immunology, Microbiology, Pharmacology and Toxicology, and research in Cellular Immunology. His doctorates in Chiropractic Medicine and Naturopathic Medicine are from the Canadian Memorial Chiropractic College and the Ontario College of Naturopathic Medicine (CCNM). As one of the 14 founding members of CCNM, now the largest Naturopathic College in the world, Dr. Wilson has long been on the forefront of alternative medicine.

About Ageology

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Age Management MD Experts Gather in Chicago for Anti-Aging CME Workshop

2012 Nobel Prize Announcements Live Stream

STOCKHOLM, October 2, 2012 /PRNewswire/ --

You can watch the live stream of the 2012 Nobel Prize announcements as the news breaks onNobelprize.org, the official website of the Nobel Prize, with live coverage from official press conferences and exclusive interviews with experts, including alerts on social media such as Twitter and Facebook.

The 2012 Nobel Prize announcements within Physiology or Medicine, Physics, Chemistry, Literature, Peace and the Prize in Economic Sciences will be live streamed on Nobelprize.org. The first announcement, for the Nobel Prize in Physiology or Medicine, is scheduled on Monday, 8 October 11:30 a.m. CET at the earliest (see the full timetable of announcements). http://bit.ly/SkccIy Exclusive content such as interviews with members of Nobel Committees explaining this year's awarded achievements will also be streamed live.

Background information about the 2012 Nobel Laureates, their Nobel Prize-awarded work and official press releases from the Nobel Prize-awarding institutions will be immediately posted.

Directly after the Nobel Laureates have heard the news, Nobelprize.org conducts a telephone interview with them, capturing the Laureates' first reactions about the news. Nobelprize.org visitors can post greetings or messages to the new Laureates directly on the website.

In addition to the live stream on Nobelprize.org, you can follow the news in several ways:

SocialMedia. Keep up with the latest news and join the conversation about the 2012 Nobel Prizes on the Nobelprize.org Facebook page: http://www.facebook.com/Nobelprize.org, or Twitter: @nobelprize_org, http://twitter.com/Nobelprize_org (#NobelPrize).

Smartphone App. Download the official Nobel Prize mobile application available on Android Apps on Google Play. http://bit.ly/QCq3qz

LiveVideoPlayer. Do you want to live-stream the Nobel Prize Announcements on your web site, blog or social networks? Get the easy-to-add code that will allow you to embed the live video player. http://bit.ly/Tw6wOu

About Nobelprize.org and Nobel Media AB

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2012 Nobel Prize Announcements Live Stream

Ventana Unveils the Latest in Digital Pathology and Lab Workflow Solutions at IAP 2012 in Cape …

TUCSON, Ariz.- At this year's 29th Congress of the International Academy of Pathology (IAP 2012), Ventana Medical Systems, Inc. (Ventana), a member of the Roche Group, will unveil the latest versions of its Virtuoso digital pathology image and workflow management software and VANTAGE workflow solution for histology lab specimen tracking. IAP 2012, one of the premier pathology conferences worldwide, takes place September 30 through October 5, 2012 in Cape Town, South Africa.

"I am thrilled to be presenting our latest products at this year's IAP," explained Steve Burnell, PhD, Lifecycle Leader for Digital Pathology and Workflow for Ventana Medical Systems, Inc. "The global adoption of digital pathology and lab workflow solutions is gaining momentum, driven by benefits to laboratory efficiency and productivity, as well as improvements in patient care. As the established innovation leader in these areas, the Ventana launch of Virtuoso 5.3 - with a user interface now available in 21 languages - and VANTAGE 2.2 - with improved integration, underscores our commitment to pathologists, laboratory staff and patients to deliver the most innovative products in the industry."

Virtuoso web-based software orchestrates the digital slide workflow from the moment the slide is scanned until the slide image is viewed and the case results reported. With Virtuoso 5.3, Ventana has expanded the user interface to 21 languages, making it easy for international customers to adopt this new technology.

"I am pleased to see Ventana continue to take a leadership role in digital pathology with the latest offering of its Virtuoso software released in multiple languages. This is a reflection of the strong interest in digital pathology from labs across the globe. Virtuoso not only increases the effectiveness of labs like mine working with cases from Mexico and the US, but also enables us to improve patient care." Jesus Ellin - Yuma Regional Medical, Yuma, AZ USA.

The market-leading VANTAGE workflow solution automates, streamlines, and integrates lab work and information flow to provide increased productivity and patient safety gains. The VANTAGE 2.2 release introduces increased Laboratory Information System (LIS) integration capabilities, touchscreen workflow enhancements and case assembly improvements in response to global customers' needs. Through its integration with Virtuoso software, the VANTAGE workflow solution enables pathologists and lab managers to track the progress of a slide from preparation to digitization along with other critical slide information, giving a lab unprecedented visibility into its processes and tools to optimize lab workflow.

Ventana's newest scanner, the VENTANA iScan HT slide scanner, will also be showcased at IAP 2012. The VENTANA iScan HT is the most powerful scanner in anatomic pathology today, enabling pathologists and lab managers to optimize their digital pathology workflow with efficiency, convenience, speed, throughput and reliability for unprecedented results. The VENTANA iScan HT slide scanner is ideal for high throughput and high volume applications. It complements the VENTANA comprehensive suite of digital pathology solutions which also includes the iScan Coreo slide scanner, Virtuoso software, and the most comprehensive portfolio of research use only (RUO), CE-IVD and FDA-cleared 510(k) image analysis algorithms available.

"Since the acquisition of BioImagene two years ago, Roche and Ventana have invested heavily in Digital Pathology, bringing a wide range of innovative new products to the market. We believe that by driving the rapid adoption of digital pathology and improved workflow globally, we will help improve patient care. Our customers can expect sustained and unparalleled innovation from Ventana in the future," says Mara G. Aspinall, President of Ventana Medical Systems, Inc.

Watch the video: VENTANA iScan HT.

To view the entire suite of Ventana digital pathology and workflow products, including the Virtuoso -VANTAGE software integration, visit the Roche Diagnostics booth during the 29th Congress of the International Academy of Pathology from September 30th through October 5th, 2012 in Cape Town, South Africa.

About Ventana Medical Systems, Inc.

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Ventana Unveils the Latest in Digital Pathology and Lab Workflow Solutions at IAP 2012 in Cape ...

Healthcare Up 4.6%; New Star Nutrition Distributor; Munson Adopts EMC's IT – Health Min 10/1/12 – Video

01-10-2012 22:56 Healthcare spending was up by 4.6 percent in 2011, according to a new report by the Health Care Cost Institute. That's higher than the 3.8 percent increase reported for 2010. The report is based on claims data of more than 40 million insured, about 25 percent of all those with employer-sponsored health insurance, ESI. 2011 healthcare spending for people with ESI averaged $4547 per person for the year. Star Nutrition, a California-based health and wellness industry company, has added Peak Performance Products as the newest Canadian distributor for its Incrediwear brand. Incrediwear products, including socks, insoles, and braces, provide benefits such as additional blood flow, thermal regulation, and wicking moisture to allow users to train harder and longer, and recover faster from workouts while aiding pain relief to injured body parts. Other companies working with Peak include Nogii, Dymatize, BPI Sports, Organique, and other athletic, lifestyle, and beauty products. EMC's IT has been adopted by Munson Healthcare, a regional group of eight hospitals and five clinics in Michigan, to transform the system's IT infrastructure and deliver new IT services. Munson has created a Health Information Exchange to enable providers to facilitate a high level of patient care through a private cloud enabled by EMC and VMware technologies. For more information on these and other stories, go to http://www.csrminute.com. The Health Minute is produced for 3BL Media by Video4Good

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Healthcare Up 4.6%; New Star Nutrition Distributor; Munson Adopts EMC's IT - Health Min 10/1/12 - Video

Both obesity and under-nutrition affect long-term refugee populations

Public release date: 2-Oct-2012 [ | E-mail | Share ]

Contact: Sumrina Yousufzai syousufzai@plos.org 415-568-3164 Public Library of Science

Both obesity and under-nutrition are common in women and children from the Western Sahara living in refugee camps in Algeria, highlighting the need to balance both obesity prevention and management with interventions to tackle under-nutrition in this population, according to a study by international researchers published in this week's PLOS Medicine.

The authors, led by Carlos Grijalva-Eternod and Andrew Seal from the UCL Institute of Child Health in London, surveyed 2005 households in this refugee population who have been living in four refugee camps since 1975 and measured and weighed 1,608 young children and 1,781 women. They found that obesity and overweight in women affected more households than acute malnutrition, stunting and underweight in children: 9.1% children had acute malnutrition, 29.1% were stunted, 8.6% were underweight and 2.4% were overweight, while among the women, 14.8% were stunted, 53.7% were overweight, and 71.4% had central obesity.

Overall, the authors classified a third of households as being overweight, a quarter as undernourished, and a quarter as affected by the double burden of obesity and malnutrition.

These results are important: 15.4 million refugees (based on 2010 figures) are dependent on host governments and international humanitarian agencies for their food, so it is essential that these governments and organizations provide appropriate food assistance programs to refugees, especially long-term refugees.

The authors say: "The results raise crucial and challenging issues for the design of refugee assistance programmes, and the future provision of care for obesity-associated co-morbidities among Sahrawi refugees and other similar populations."

They continue: "Careful policy and advocacy work will be required to convey the complexity of the situation, and to ensure that continued support for life-saving food assistance programmes and the tackling of under-nutrition and nutritional deficiencies is not jeopardised as the threat of obesity to refugee health receives the attention it deserves."

###

Funding: This work was partly funded by the European Community Humanitarian Office, the United Nations High Commissioner for Refugees (UNHCR), and the United Nations World Food Programme. Part of this work was undertaken at the Centre for Paediatric Epidemiology and Biostatistics, which benefits from funding support from the MRC in its capacity as the MRC Centre of Epidemiology for Child Health. The UCL Institute of Child Health receives a proportion of funding from the Department of Health's National Institute for Health Research Biomedical Research Centres funding scheme. UNHCR personnel participated in the study design, data collection, data interpretation, and contributed revisions to the manuscript. All other sponsors of the study had no role in study design, data collection, data analysis, data interpretation, writing of the report, and in the decision to submit the paper for publication.

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Both obesity and under-nutrition affect long-term refugee populations

Obesity and under-nutrition prevalent in long-term refugees living in camps

Public release date: 2-Oct-2012 [ | E-mail | Share ]

Contact: David Weston d.weston@ucl.ac.uk 44-020-310-83844 University College London

A quarter of households in refugee camps in Algeria are currently suffering from the double burden of excess weight and under-nutrition. According to a study published in the journal PLOS Medicine, obesity is an emerging threat to this community, with one in two women of childbearing age being overweight, whilst nutritional deficiencies such as iron-deficiency anaemia and stunted growth remain a persistent problem.

The collaborative study by the UCL Institute of Child Health (ICH), the Emergency Nutrition Network (ENN), and the United Nations High Commissioner for Refugees (UNHCR), looked at the prevalence of the 'double burden' of malnutrition under-nutrition and obesity - among Western Sahara (Sahrawi) refugees living in a prolonged emergency situation, who rely mostly on humanitarian food assistance for survival.

Over 1,600 children and 1,700 women from 2,005 households took part in a routine UNHCR nutrition survey in 2010, which collects and monitors health and nutrition indicators of refugee children under five and women of childbearing age (15-49 years). The Sahrawi refugees are based in four camps originally set up in 1975 near Tindouf city in Algeria. Many adults have, from birth, received food assistance as their main source of food, and their children are now the second or third generation living on a diet consisting mainly of refined starchy foods.

The nutrition survey recorded the weight and height of women and children, and waist circumference of women, to determine the prevalence of global acute malnutrition (GAM, which includes thin 'wasted' children and those with nutritional oedema or swelling), stunting (a low height for age) and underweight, and overweight (a low and high weight for age, respectively) in children; and stunting, underweight and overweight (a body mass index lower than 18.5 kg/m2 and higher than 25 kg/m2, respectively), and central obesity (a waist circumference of more than 80 cm) in women.

Nine per cent of children were found to have GAM, while 29 per cent were stunted, 18 per cent were underweight, and 2.4 per cent were overweight. In women, 15 per cent were stunted, 54 per cent were overweight or obese, and 71 per cent had central obesity. Notably, central obesity and overweightness in women affected more households than under-nutrition in children. Overall, a third of the households were classified as overweight, a quarter as undernourished, and a quarter as double burden-affected.

Based on the findings, the paper makes a number of recommendations: to revise food assistance policies to take into consideration the longer term effects of meeting minimum nutritional needs in emergencies; and to promote long-term food security in protracted emergencies, for example by encouraging the refugee community to adopt small-scale gardening and food-growing schemes. Innovative approaches and resources may be needed to encourage behavioural change in these communities, given that a more sedentary lifestyle may also be contributing to the rise in obesity.

Carlos Grijalva-Eternod, lead-author, UCL Institute of Child Health, says: "Over a third of the children surveyed showed signs of malnutrition and 15 per cent of women showed signs of having experienced nutritional deficiencies during their development; at the same time, over half the women surveyed were overweight. These high levels of obesity do not imply that this population receives excessive or even adequate nutrition, given the high prevalence of undernourished children and stunted women. Rather, the population's diet may be suboptimal for health."

"A number of reasons may account for these trends. This traditionally nomadic population itself once favoured larger women, and has an excessive sugar consumption habit. However, other factors come into play, such a predominance of starchy foods, pulses and blended foods in food assistance packages, but with few, if any, fresh or dried vegetables and fruit. We need to find ways of boosting the supply of fresh produce to improve the adequacy and diversity of their diets."

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Obesity and under-nutrition prevalent in long-term refugees living in camps

New antibiotic cures disease by disarming pathogens, not killing them

Public release date: 2-Oct-2012 [ | E-mail | Share ]

Contact: Jim Sliwa jsliwa@asmusa.org 202-942-9297 American Society for Microbiology

A new type of antibiotic can effectively treat an antibiotic-resistant infection by disarming instead of killing the bacteria that cause it. Researchers report their findings in the October 2 issue of mBio, the online open-access journal of the American Society for Microbiology.

"Traditionally, people have tried to find antibiotics that rapidly kill bacteria. But we found a new class of antibiotics which has no ability to kill Acinetobacter that can still protect, not by killing the bug, but by completely preventing it from turning on host inflammation," says Brad Spellberg of the UCLA Medical Center and David Geffen School of Medicine, a researcher on the study.

New drugs are badly needed for treating infections with the bacterium Acinetobacter baumannii, a pathogen that most often strikes hospital patients and immune- compromised individuals through open wounds, breathing tubes, or catheters. The bacterium can cause potentially lethal bloodstream infections. Strains of A. baumannii have acquired resistance to a wide range of antibiotics, and some are resistant to every FDA-approved antibiotic, making them untreatable.

Spelling and his colleagues found that in laboratory mice it was possible to mitigate the potentially lethal effects of the bacterium by blocking one of its toxic products rather than killing it.

"We found that strains that caused the rapidly lethal infections shed lipopolysaccharide [also called LPS or endotoxin] while growing. The more endotoxin shed, the more virulent the strain was," says Spellberg. This pinpointed a new therapy target for the researchers: the endotoxin these bacteria shed in the body.

Blocking the synthesis ofthe endotoxin with a small molecule called LpxC-1 prevented infected mice from getting sick. Unlike traditional antibiotics, Spellberg says, LpxC-1 doesn't kill the bacteria, it just shuts down the manufacture of the endotoxin and stops the body from mounting the inflammatory immune response to it that is the actual cause of death in seriously ill patients.

Spellberg says this is a direction few researchers have taken when exploring ways to treat infections but that it could make the difference in finding an effective drug. The results also highlight how important it is to find new, physiologically relevant ways of screening potential antibiotics for pathogens with a high degree of resistance, write the authors. Molecules like LpxC-1 that inhibit rather than kill bacteria wouldn't pass muster with traditional antibiotic screens that are based on killing effectiveness.

Liise-anne Pirofski of the Albert Einstein College of Medicine and a reviewer of the study for mBio says neutralizing virulence factors is showing a lot of promise as an alternative route for treating infections. "There's a growing movement in infectious disease therapy to control the host inflammation response in treatment rather than just 'murdering' the organism," says Pirofski. "This is a very elegant and important validation that this approach can work at least in mice."

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New antibiotic cures disease by disarming pathogens, not killing them

Longevity Global Inc. Made The Season's Biggest Launch By Unveiling An Advanced Model Of TIG Welder

Longevity Global Inc. has made the season's best launch this Monday. The company has launched the most advanced aluminum welder the world has ever seen. Their new model TigWeld 200SX is a multi- purpose welding equipment which is fully loaded with the most advanced features.

Hayward, CA (PRWEB) October 02, 2012

Industries have grown significantly and welding has become one of the most important elements for almost every industry, may it be directly or indirectly related. With people growing as per their standard of living, they have started building houses that are stronger, and to achieve that strength usage of metals in important and welding gets involved. Welding is a process in which two or more metal pieces are merged with the help of a molten solution. As the name implies, aluminum welding utilizes aluminum during the welding process. Aluminum is a versatile metal with usage in several areas. Aluminum welder equipment can be used for repairing corroded regions, oil impregnated areas and other areas which need aluminum welding. Even if a person does not know anything about this, he can use and operate aluminum welder equipment easily.

There are several models of aluminum welders available in the product line of Longevity Global Inc. Although there are vast numbers of welding equipment available at Longevity's inventory but aluminum welder machine TigWeld 200SX is that precise welding device which can further enhance the quality of welding jobs. This compact, dual-voltage voltage, versatile unit offers the user a simple array of controls to accurately set the welder to perform under a wide variety of situations including fine aluminum welding. The TIGWELD 200 SX allows the welder to easily switch from 220v to 110v with the adapter plug that is included while being able to produce 200 amps on both AC and DC TIG and 160 amps on Stick. Whether welding aluminum or any other metal, the TIGWELD 200 SX benefits from cutting edge inverter technology. This allows Longevity to offer a welder with more stability while at the same time the unit is more lightweight and reliable.

Longevity Global Inc. is providing its dedicated service since 2001. It is growing at a phenomenal pace with high customer satisfaction, new and used welders, cutters and efficient industrial production for welding purposes. It works in different parts of world with distributors in Canada, Mexico, Brazil, Australia, United Kingdom, and multiple other countries. Longevity Global Inc. serve globally with manufacturing facilities with its logistic companies to effectively distribute products in a punctual and effective manner.

To know more visit http://www.longevity-inc.com.

Simon Katz Longevity, Inc. 1.877.566.4462 Email Information

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Longevity Global Inc. Made The Season's Biggest Launch By Unveiling An Advanced Model Of TIG Welder

Fasano Life Settlement & Longevity Conference Agenda: Cutting Edge!

WASHINGTON--(BUSINESS WIRE)--

Fasano Associates released the agenda for its October 29th Life Settlement and Longevity Conference, which Fasanos President, Michael Fasano, described as Investor Focused and Cutting Edge.

The Conference will include keynote presentations by award winning political analyst, Howard Fineman, and Dr. Mark Lacks, Chief of Geriatrics at Cornell Universitys Weill Medical College. Fineman will speak to the Impact of the Upcoming Elections, while Dr. Lacks will present the Impact of Functional Status on Longevity in the Elderly. Said Michael Fasano, Investors have been given all kinds of esoteric analyses to explain why some people outlive others; but for some reason, many lose sight of the basics. Dr. Lacks, who is a renown expert in geriatrics, will explain why Activities of Daily Living and Functional Status are among the most important and basic markers of longevity in the elderly.

The Conference also will include groundbreaking research by Drs. Kent Smetters and Daniel Gottlieb of the Wharton School demonstrating How Life Settlements Enhance Consumer Welfare and a point-counterpoint discussion with litigators from Drinker Biddle and Orrick, Herrington & Sutcliffe on the Future of Life Settlement Litigation.

Fasano added, Our Conference has earned a reputation for excellence and this years agenda is as good as it gets. Drs. Jochen Russ and Daniel Bauer will be presenting cutting edge research on A New Methodology for Measuring Actual to Expected Performance, while investment experts, Jeff Serra of Vida Capital and Bill Corry of Corry Capital, will raise questions on the relevance of the traditional provider model in their panel on the Advantages of Investor/Provider Vertical Integration.

The Conference will also include a presentation on the Use of Indices and Other Synthetic Structures in Financial Markets by Olivier Dauget, Managing Director of Societe Generale.

The Fasano Conference is a one-day event, with cocktails and dinner following the presentations. With a registration fee of only $395 and eight original presentations, Fasano characterized its Conference as the best value in the business. The detailed agenda and information about invitations to the Conference are available at http://www.fasanoassociates.com.

About Fasano Associates:

Fasano Associates is a leading underwriting consulting firm serving the life, health and life settlement industries.

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Fasano Life Settlement & Longevity Conference Agenda: Cutting Edge!

Animals engineered with pinpoint accuracy

A cow in New Zealand has been genetically modified to produce hypoallergenic milk.

AgResearch

Two genetically engineered farm animals reported today illustrate how far from Frankensteins stitched-together monster animal biotechnology has come. One of those animals, a cow, secretes milk that lacks an allergy-inducing protein because researchers accurately blocked its production using the technique of RNA interference1. And in pigs, scientists have used an enzyme called a TALEN2 to scramble a gene that would normally help remove cholesterol.

RNA interference (RNAi) and TALENs are more accurate at targeting the gene in question than are earlier genetic engineering techniques. For years, researchers tried to remove the allergy-inducing milk protein beta-lactoglobulin from cow's milk, which can cause diarrhea and vomiting in some toddlers. They tried replacing the gene encoding beta-lactoglobulin with a defective form, but this proved nearly impossible because the techniques available to introduce foreign genes into animal genomes were not precise, and misplaced genes failed to express themselves correctly.

In 2006, scientists at AgResearch in Hamilton, New Zealand began to experiment with molecules that interfere with the messenger RNA go-between that enables translation of a gene into protein. In mice, they discovered a short chunk of RNA, called a microRNA, that targeted beta-lactoglobulin messenger RNA directly to prevent its translation. They inserted DNA encoding a version of this microRNA into the genome to create genetically modified cow embryos that they hoped would grow into cows without the allergen in their milk. Out of 100 embryos, one calf yielded beta-globulin-free milk. This isnt a quick process, says Stefan Wagner, a molecular biologist at AgResearch. That's why it has taken so long to succeed in making an allergen-free cow, he says.

Wagner says that TALENs, which were not readily available when he began his research, might speed up the process, and that the team plans to use them to eliminate beta-lactoglobulin. RNAi cannot eliminate the protein completely because some messenger RNA slips past the blockade, but each TALEN targets a specific DNA sequence in the genome and cuts it. As the body repairs the break, mutations are often introduced that render the targeted gene non-functional. The TALEN technology is staggeringly easy, quick, and leaves no mark in the genome, says Bruce Whitelaw, a molecular biologist at the Roslin Institute near Edinburgh in the United Kingdom, who contributed to the work in pigs. In essence, we are just mimicking an evolutionary process with precise, man-made editors.

His team used TALENs to disrupt genes encoding low-density lipoprotein (LDL) receptors. Without these receptor proteins to remove cholesterol-containing LDLs from the blood, LDLs build-up and lead to atherosclerosis. Pigs with this condition may be reliable models of human atheroscelerosis in biomedical research.

The TALEN-modified pig is not the first model of human heart disease (see Model pigs face a messy path), but the technique makes genetic engineering less costly and more efficient. Id be exaggerating if I said that pigs and cows can now be thought of as big mice, but we are moving in that direction, says Heiner Niemann, a bioengineer at the Institute of Farm Animal Genetics in Neustadt, Germany.

The excitement surrounding these technological advances is bittersweet, however. Originally, engineered animals were produced with the aim of making food safer, healthier and more abundant. Yet despite years of investment, almost no animal has been approved by regulatory agencies around the world. Wagner says he has not tasted the milk from his special cow because hes not permitted to under New Zealand law. We must restrict our research to scientific analysis, he says. The current climate for animal biotech is not very good, and therefore, we are nowhere near getting this to the consumer."

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Animals engineered with pinpoint accuracy